IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AURKC Ensembl ENSG00000105146 Chromosome 19 Start 62434240 End 62438727
Description Serine/threonine-protein kinase 13 (EC 2.7.11.1)(Aurora/Ipl1/Eg2 protein 2)(Aurora/Ipl1-related kinase 3)(Aurora-C) [Source:UniProtKB/Swiss-Prot;Acc:Q9UQB9]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11391
     Entrez Gene : 6795
     UCSC : uc002qoe.2
     GeneCards : 11391
     RefSeq : NM_001015878
     CCDS : CCDS33128.1
     Uniprot : Q9UQB9
     Interpro : Q9UQB9
     OMIM : 603495
     GeneTests : AURKC
     CGAP : AURKC
     PMID : 9799611

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
3 1.09 276 1 0.45 223 1 5.56 18
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
PD1342a AD c.630C>A p.H210Q Substitution - Missense Unknown 19:62438211-6243821116140923
PD0265a SCC c.340G>C p.E114Q Substitution - Missense Unknown 19:62436646-6243664616140923

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37088_at  0.09  4.91e-1  5.96e-1  -0.12  5.26e-1  6.25e-1
 HG_U133A  211107_s_at  -0.45  5.43e-11  2.11e-10  2.15  5.79e-70  1.88e-69
 HG_U133_Plus2  211107_s_at  -0.77  1.06e-5  4.04e-5  -0.14  4.67e-1  5.28e-1
 Agilent_HS_21.6K  8272  0.02  5.18e-1  6.89e-1  0.01  7.63e-1  8.50e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  211107_s_at  -0.15  4.82e-1  9.26e-1  -0.03  8.35e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37088_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211107_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211107_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8272    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
aik3 tumor AIK3 gene was assigned to human chromosome 19q13.43, which is a frequently deleted or rearranged region in several tumor tissues, by fluorescence in situ hybridization, somatic cell hybrid panel, and radiation hybrid cell panel. 10066797 Human
aik3 cancer The expression levels of AIK3 in several cancer cell lines were elevated severalfold compared with normal fibroblasts. 10066797 Human

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