IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene BUB1B Ensembl ENSG00000156970 Chromosome 15 Start 38240530 End 38300627
Description Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1)(MAD3/BUB1-related protein kinase)(hBUBR1)(Mitotic checkpoint kinase MAD3L)(Protein SSK1) [Source:UniProtKB/Swiss-Prot;Acc:O60566]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1149
     Entrez Gene : 701
     UCSC : uc001zkx.3
     GeneCards : 1149
     RefSeq : NM_001211
     CCDS : CCDS10053.1
     Uniprot : Q59HH6
     Interpro : Q59HH6
     OMIM : 602860
     GeneTests : BUB1B
     CGAP : BUB1B
     PMID : 9889005

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 8/8(100%) qRT-PCR- 12445743 Lung Cancer. 2002 Dec;38(3):229-34.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35699_at  1.05  1.14e-8  1.14e-7  2.24  9.93e-16  3.71e-14
 HG_U133A  203755_at  1.49  9.37e-44  3.28e-42  2.78  8.48e-67  2.60e-66
 HG_U133_Plus2  203755_at  2.09  2.29e-39  4.38e-37  3.00  1.52e-46  1.04e-43
 Stanford  19370  2.00  1.86e-5  1.10e-3  2.75  5.42e-8  1.35e-5
 Agilent_HS_21.6K  4948  0.10  4.05e-3  2.30e-2  0.18  6.32e-4  3.72e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203755_at  0.38  3.14e-1  8.80e-1  0.09  6.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35699_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203755_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203755_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19370    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4948    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hbubr1 human colon adenocarcinomas In addition, the level of hBubR1 is significantly reduced not only in polyploid cells created by sustained mitotic spindle damage, but also in 21 (31.3%) of 67 human colon adenocarcinomas tested. 14706340 Human
hbubr1 tumors Importantly, the introduction of hBubR1 triggers the apoptosis of polyploid cells formed by aberrant exit from mitosis and inhibits the growth of tumors established with these cells in athymic nude mice. 14706340 Mouse
bubr1 tumor While some polymorphic base changes were noted in BUB1, BUBR1, and CDC20, no mutations responsible for impairment of the mitotic checkpoint were found in either the HCC cell lines or HCC specimens, which suggests that these genes did not seem to be involv 11932908 Human
bubr1 thyroid cancer Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. 11940046 Human
bubr1 thyroid cancer We examined the contribution of mitotic checkpoint dysfunction and mutations of BUB1 or BUBR1, components of the spindle assembly checkpoint pathway, to chromosomal instability in thyroid cancer. 11940046 Human
bubr1 neoplasms Moreover, mutations of BUB1 or BUBR1 are infrequent in follicular neoplasms, and do not account for aneuploidy in thyroid cancer. 11940046 Human
bubr1 thyroid cancer Moreover, mutations of BUB1 or BUBR1 are infrequent in follicular neoplasms, and do not account for aneuploidy in thyroid cancer. 11940046 Human
bubr1 cancer Suppression of Mad2 and BubR1 in paclitaxel-treated cancer cells abolished checkpoint function, resulting in paclitaxel resistance that correlated with suppression of cyclin-dependent kinase-1 activity. 15059905 Human
bubr1 tumors Mutations of Bub1 or BubR1, genes coding for kinases involved in mitotic spindle assembly checkpoint signaling, are found in a small subset of aneuploid tumors. 11981026 Human
bubr1 lung cancer The promoter region of the human BUBR1 gene and its expression analysis in lung cancer. 12445743 Human
hbubr1 cancers Recent reports suggest that the hBUBR1 gene may play an important role in mitotic checkpoint control and in mitotic checkpoint impairment in human cancers. 12445743 Human
hbubr1 lung cancer We analyzed the expression of hBUBR1 in lung cancer cell lines using real time quantitative RT-PCR. 12445743 Human
hbubr1 cancers Knowledge of the genomic structure and the promoter region of the hBUBR1 gene will facilitate investigation of its role in mitotic checkpoint control and tumor progression in human cancers. 12445743 Human
hbubr1 tumor Knowledge of the genomic structure and the promoter region of the hBUBR1 gene will facilitate investigation of its role in mitotic checkpoint control and tumor progression in human cancers. 12445743 Human
bubr1 human lung cancers Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. 11146226 Human
bubr1 lung cancers We found that the BUB gene family members including BUB1, BUBR1 and BUB3 are not frequent targets for mitotic checkpoint defects in lung cancers, if present at all. 11146226 Human
hbubr1 glioblastoma DNA sequencing revealed a silent mutation at codon 144 of hBUB1 (CAG-->CAA, Gln-->Gln) in one glioblastoma, a silent mutation at codon 952 of hBUBR1 (GAC-->GAT, Asp-->Asp) in another glioblastoma, and a silent mutation at codon 388 of the hBUBR1 gene (GCG 11355300 Human
bubr1 tumor Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. 14744753 Mouse
bubr1 cancers Loss of function mutations of BubR1, an important component of the spindle checkpoint, have been detected in human cancers. 14744753 Human
bubr1 tumor BubR1 is thus essential for spindle checkpoint activation and tumor suppression. 14744753 Mouse
bub1b breast cancer Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. 10773412 Human
hbubr1 human lung cancer Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. 10835495 Human
hbubr1 colon cancers Since hBUB1 and hBUBR1, whose products function in the spindle checkpoint pathway, have been shown to be mutated in a subset of colon cancers with chromosomal instability, we investigated the contribution of these genes to lung cancer development. 10835495 Human
hbubr1 lung cancer Since hBUB1 and hBUBR1, whose products function in the spindle checkpoint pathway, have been shown to be mutated in a subset of colon cancers with chromosomal instability, we investigated the contribution of these genes to lung cancer development. 10835495 Human
hbubr1 mesothelioma One hundred and two lung cancer (50 small cell lung cancers and 52 non-small cell lung cancers) and 4 mesothelioma cell line DNAs were analyzed by Southern blot analysis, but no rearrangements or deletions of hBUB1 and hBUBR1 were detected. 10835495 Human
hbubr1 lung cancer One hundred and two lung cancer (50 small cell lung cancers and 52 non-small cell lung cancers) and 4 mesothelioma cell line DNAs were analyzed by Southern blot analysis, but no rearrangements or deletions of hBUB1 and hBUBR1 were detected. 10835495 Human
hbubr1 small-cell lung cancers One hundred and two lung cancer (50 small cell lung cancers and 52 non-small cell lung cancers) and 4 mesothelioma cell line DNAs were analyzed by Southern blot analysis, but no rearrangements or deletions of hBUB1 and hBUBR1 were detected. 10835495 Human
hbubr1 non-small cell lung cancers One hundred and two lung cancer (50 small cell lung cancers and 52 non-small cell lung cancers) and 4 mesothelioma cell line DNAs were analyzed by Southern blot analysis, but no rearrangements or deletions of hBUB1 and hBUBR1 were detected. 10835495 Human
hbubr1 lung cancer Similar mutation analysis of hBUBR1 in 47 lung cancer cell line cDNAs revealed a frequent polymorphism at codon 349 (CAA to CGA) leading to a substitution of Gln to Arg but no mutations. 10835495 Human
hbubr1 lung cancer Northern blot analyses showed that both hBUB1 and hBUBR1 genes were expressed in all of 31 lung cancer cell lines tested with no significant difference in the expression level. 10835495 Human
hbubr1 lung cancers Our results suggest that alterations in hBUB1 and hBUBR1 rarely contributed to the genetic change of lung cancers. 10835495 Human
hbubr1 adult t-cell leukemia lymphoma Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. 10960763 Human
hbubr1 colorectal tumor Recently, human homologues of the BUB were identified and mutant alleles of hBUB1 and hBUBR1 were detected in two colorectal tumor cell lines, which showed microsatellite instability (MIN). 10960763 Human
hbubr1 b-cell lymphomas In contrast, only one of eight B-cell lymphomas showed nonsense mutation of hBUBR1. 10960763 Human
mad3l tumors These findings are mirrored in the genetic lesions sustained in tumors found in the rare BRCA2Tr/Trmice that survive to adulthood, which include defects in p53 as well as the mitotic checkpoint proteins Bub1 and Mad3L. 11250674 Mouse
hbubr1 human colorectal cancers Sequence alterations of mitotic checkpoint genes, hBUB1 and hBUBR1, were examined, and their gene transcripts were quantified using on-line, real-time quantitative reverse transcription-PCR in surgically resected human colorectal cancers and their neighbo 11782350 Human
hbubr1 cancers Our results reveal a new hBUB1 missense mutation (Ala130Ser) but not any hBUBR1 coding sequence mutations. hBUB1 and hBUBR1 mRNA levels were reduced to < 10% of the neighboring normal tissues in 3 of 103 and 3 of 109 carcinomas, respectively, and to < 50% 11782350 Human
hbubr1 carcinomas Our results reveal a new hBUB1 missense mutation (Ala130Ser) but not any hBUBR1 coding sequence mutations. hBUB1 and hBUBR1 mRNA levels were reduced to < 10% of the neighboring normal tissues in 3 of 103 and 3 of 109 carcinomas, respectively, and to < 50% 11782350 Human
hbubr1 lymph-node metastasis Carcinomas with reduced hBUB1 and/or hBUBR1 mRNA levels, as well as the colon carcinoma harboring the hBUB1 mutation, were associated with lymph node metastasis (P < 0.005) and shorter relapse-free survival after surgery (P = 0.006). 11782350 Human
hbubr1 colon carcinoma Carcinomas with reduced hBUB1 and/or hBUBR1 mRNA levels, as well as the colon carcinoma harboring the hBUB1 mutation, were associated with lymph node metastasis (P < 0.005) and shorter relapse-free survival after surgery (P = 0.006). 11782350 Human
hbubr1 carcinomas Carcinomas with reduced hBUB1 and/or hBUBR1 mRNA levels, as well as the colon carcinoma harboring the hBUB1 mutation, were associated with lymph node metastasis (P < 0.005) and shorter relapse-free survival after surgery (P = 0.006). 11782350 Human
hbubr1 tumor metastasis Thus, hBUB1 and hBUBR1 may contribute to a specific driving force in tumor metastasis and progression as a result of nonmutational, as well as mutational, inactivation. 11782350 Human
mad3l tumors Tumors from Brca2-deficient animals exhibit dysfunction of the spindle assembly checkpoint, accompanied by mutations in p53, Bub1, and Mad3L. 10445022 Mouse
hbubr1 colorectal carcinomas The kinetochore binding domain was used in a yeast two-hybrid screen to isolate interacting proteins that included the kinetochore proteins CENP-E, CENP-F, and hBUBR1, a BUB1-related kinase that was found to be mutated in some colorectal carcinomas (Cahil 9763420 Human
hbubr1 osteosarcoma In the human U2OS osteosarcoma cell line, hBUB1 first appeared at kinetochores during early prophase before all kinetochores were occupied by hBUBR1 or CENP-F. 9914370 Human
bubr1 breast cancer The specific association of BCSG1 with BubR1 in breast cancer cells was demonstrated by immunoprecipitation and GST pull-down assays. 14576821 Human
bubr1 breast cancer The tendency of endogenous BCSG1 expression coinciding with lower BubR1 protein levels was also observed in seven out of eight breast cancer cell lines. 14576821 Human
bubr1 breast cancer Accompanied with a reduction of BubR1 protein level, BCSG1 expression resulted in multinucleation of breast cancer cells upon treatment with spindle inhibitor nocodazole, indicating an impaired mitotic checkpoint. 14576821 Human
bubr1 breast cancer Taken together, our novel findings suggest that BCSG1 may accelerate the progression of breast cancer at least in part by compromising the mitotic checkpoint control through inactivation of BubR1. 14576821 Human
bub1b pancreatic cancer To determine sequence variations of the BUB1 and BUB1B genes in pancreatic cancer, the entire coding regions of the BUB1 and BUB1B genes were sequenced in pancreatic cancer cell lines and xenografts. 12655561 Human
bubr1 tumour Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation. 12692836 Human
bubr1 gastric cancer Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer--association with tumour cell proliferation. 12692836 Human
bubr1 gastric carcinomas To explore this possibility, the expression levels of BUB1, BUBR1, and BUB3 were determined in 43 gastric carcinomas and corresponding normal gastric mucosa by reverse transcription-polymerase chain reaction (RT-PCR). 12692836 Human
bubr1 gastric cancers BUB1 was overexpressed in 84%, BUBR1 in 68%, and BUB3 in 79% of gastric cancers. 12692836 Human
bubr1 tumours This study also revealed that all three genes were simultaneously overexpressed in 61% of the tumours and that there was a statistically significant positive correlation between overexpression of BUB1, BUBR1 or BUB3 and Ki-67 expression (p < 0.001). 12692836 Human
bub1b cancer Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. 15475955 Human
bub1b embryonal rhabdomyosarcoma In five families with mosaic variegated aneuploidy, including two with embryonal rhabdomyosarcoma, we identified truncating and missense mutations of BUB1B, which encodes BUBR1, a key protein in the mitotic spindle checkpoint. 15475955 Human
bub1b childhood cancers However, recently we identified mutations in the mitotic checkpoint gene BUB1B in an autosomal recessive condition characterized by mosaic aneuploidies and childhood cancers. 15655355 Human
bubr1 hcc Furthermore, the authors examined the alterations of other mitotic checkpoint genes, BUBR1, BUB3, MAD2B, and CDC20, using direct sequencing in HCC cell lines with aneuploidy. 11932908 Human
bubr1 hcc While some polymorphic base changes were noted in BUB1, BUBR1, and CDC20, no mutations responsible for impairment of the mitotic checkpoint were found in either the HCC cell lines or HCC specimens, which suggests that these genes did not seem to be involv 11932908 Human
bubr1 thymic lymphomas Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas. 14646599 Mouse
bubr1 thymic lymphomas Thymic lymphomas from Brca2-mutant mice harbor mutations in p53, Bub1, and BubR1, which function as mitotic checkpoint proteins. 14646599 Mouse
bubr1 thymic lymphomas This report demonstrates that Bub1 and BubR1 mutant proteins from Brca2-/- thymic lymphomas have defects in the phosphorylation and kinetochore localization after spindle damage. 14646599 Mouse
bubr1 tumors Thus, the mutations of Bub1 and BubR1 found in Brca2- mutant mice indeed are responsible for the chromosome instability in Brca2-mutated tumors. 14646599 Mouse
bubr1 colon cancers These studies have revealed mutation of the mitotic checkpoint regulators BUB1 and BUBR1 and amplification of STK15 in a subset of CIN colon cancers. 15000146 Human
bubr1 cancer Reducing the levels of the checkpoint proteins BubR1 or Mad2 in human cancer cells or inhibiting BubR1 kinase activity provokes apoptotic cell death within six divisions except when cytokinesis is also inhibited. 15159543 Human
bubr1 cancer Sensitivity to paclitaxel correlated with decreased BubR1 protein expression in human cancer cell lines, including those derived from breast and ovarian cancers. 15210851 Human
bubr1 breast and ovarian cancers Sensitivity to paclitaxel correlated with decreased BubR1 protein expression in human cancer cell lines, including those derived from breast and ovarian cancers. 15210851 Human
bubr1 embryonal rhabdomyosarcoma In five families with mosaic variegated aneuploidy, including two with embryonal rhabdomyosarcoma, we identified truncating and missense mutations of BUB1B, which encodes BUBR1, a key protein in the mitotic spindle checkpoint. 15475955 Human
bubr1 colorectal cancer Together, our studies suggest that BubR1 and Apc functionally interact in regulating metaphase-anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer. 15767571 Human
hbubr1 atll We examined the role of checkpoint gene in the chromosomal abnormalities of ATLL by investigating mutations of hBUB1 and hBUBR1, and MIN of replication errors of BAX, insulin-like growth factor, and transforming growth factor beta type II. 10960763 Human
hbubr1 atll Significant mutations/deletion of hBUB1 or hBUBR1 were detected in four of ten cases with ATLL, including two heterozygous point mutations, one homozygous point mutation, and one with a 47 bp deletion. 10960763 Human
hbubr1 glioblastomas Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. 11355300 Human
hbubr1 glioblastomas We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. 11355300 Human
hbubr1 glioblastomas DNA sequencing revealed a silent mutation at codon 144 of hBUB1 (CAG-->CAA, Gln-->Gln) in one glioblastoma, a silent mutation at codon 952 of hBUBR1 (GAC-->GAT, Asp-->Asp) in another glioblastoma, and a silent mutation at codon 388 of the hBUBR1 gene (GCG 11355300 Human

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