IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CCNE1 Ensembl ENSG00000105173 Chromosome 19 Start 34994741 End 35007056
Description G1/S-specific cyclin-E1 [Source:UniProtKB/Swiss-Prot;Acc:P24864]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1589
     Entrez Gene : 898
     UCSC : uc002nsn.2
     GeneCards : 1589
     RefSeq : NM_001238
     CCDS : CCDS12419.1
     Uniprot : P24864
     Interpro : P24864
     OMIM : 123837
     GeneTests : CCNE1
     CGAP : CCNE1
     PMID : 1833066

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.50 199 1 0.53 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17784 AD c.283C>T p.R95W Substitution - Missense Heterozygous 19:34999986-3499998618948947

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 29/70(41%) qRT-PCRKaplan-Meier plots(P=0.03) 11212263 Cancer Res. 2001 Jan 15;61(2):647-53.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  2021_s_at  0.66  6.64e-6  3.60e-5  0.76  6.93e-5  2.87e-4
 HG_U95  41060_at  1.49  3.91e-13  9.16e-12  2.26  1.88e-12  3.57e-11
 HG_U133A  213523_at  1.20  9.28e-21  7.72e-20  -0.58  7.89e-6  9.19e-6
 HG_U133_Plus2  213523_at  1.76  3.62e-22  1.06e-20  2.38  1.36e-31  7.57e-30
 HG_U133_Plus2  242105_at  0.49  1.10e-2  2.23e-2  0.71  1.27e-3  2.40e-3
 Stanford  20693  1.52  3.27e-4  7.03e-3  1.95  2.76e-5  1.08e-3
 Agilent_HS_21.6K  11000  0.21  1.48e-3  1.05e-2  0.32  5.63e-8  1.33e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  213523_at  0.50  4.18e-1  9.08e-1  -0.10  6.60e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 2021_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41060_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213523_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213523_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242105_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20693    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11000    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cyclin e adenomas To detail changes of p57KIP2 during colorectal carcinogenesis and during late metastasis to lymph nodes, p57KIP2, cyclin A, cyclin B1, cyclin E, CDK2, and Ki67 were immunohistochemically investigated in 22 specimens of normal mucosa, 62 of adenomas, 17 of 14612924 Human
cyclin e metastasis to lymph nodes To detail changes of p57KIP2 during colorectal carcinogenesis and during late metastasis to lymph nodes, p57KIP2, cyclin A, cyclin B1, cyclin E, CDK2, and Ki67 were immunohistochemically investigated in 22 specimens of normal mucosa, 62 of adenomas, 17 of 14612924 Human
cyclin e primary carcinomas To detail changes of p57KIP2 during colorectal carcinogenesis and during late metastasis to lymph nodes, p57KIP2, cyclin A, cyclin B1, cyclin E, CDK2, and Ki67 were immunohistochemically investigated in 22 specimens of normal mucosa, 62 of adenomas, 17 of 14612924 Human
cyclin e lymph-node metastases To detail changes of p57KIP2 during colorectal carcinogenesis and during late metastasis to lymph nodes, p57KIP2, cyclin A, cyclin B1, cyclin E, CDK2, and Ki67 were immunohistochemically investigated in 22 specimens of normal mucosa, 62 of adenomas, 17 of 14612924 Human
cyclin e carcinomas in adenomas To detail changes of p57KIP2 during colorectal carcinogenesis and during late metastasis to lymph nodes, p57KIP2, cyclin A, cyclin B1, cyclin E, CDK2, and Ki67 were immunohistochemically investigated in 22 specimens of normal mucosa, 62 of adenomas, 17 of 14612924 Human
cyclin e oral squamous-cell carcinoma Loss of cyclin E requirement in cell growth of an oral squamous cell carcinoma cell line implies deregulation of its downstream pathway. 15185338 Human
cyclin e1 oral squamous-cell carcinoma We examined the expression profile of cyclin E1 and E2 in cell lines derived from human oral squamous cell carcinoma (SCC), and found that the expression of cyclin E1 protein was hardly detected in HSC-2 cells. 15185338 Human
cyclin e tumor Troglitazone caused the suppression of cell growth, which was suggested to result from the decrease in cyclin E and the hyperphosphorylated form of retinoblastoma tumor suppressor gene product (pRb). 11834241 Human
cyclin e retinoblastoma Troglitazone caused the suppression of cell growth, which was suggested to result from the decrease in cyclin E and the hyperphosphorylated form of retinoblastoma tumor suppressor gene product (pRb). 11834241 Human
cyclin e retinoblastoma Immunohistochemical studies were performed on CPPs and CPCs in this patient population and on non-neoplastic choroid epithelium using antibodies to MIB-1, p53, cyclin E, retinoblastoma protein (pRB), p107, and E2F-1. 11837741 Human
cyclin e1 primary tumor Although the pattern and level of cyclin E2 expression in some primary tumor and normal tissue RNAs are distinct from cyclin E1, both E-type cyclins appear to have inherent functional redundancies. 11854029 Human
cyclin e tumor Apoptosis and generation of p18-cyclin E were significantly inhibited by overexpressing the cleavage-resistant cyclin E mutant, indicating a functional role for caspase-dependent proteolysis of cyclin E for apoptosis of hematopoietic tumor cells. 11884622 Human
cyclin e breast cancer In order to further analyze the role of CEACAM1 in the development of breast cancer, we performed Western-blot analysis and immunohistochemistry with highly specific monoclonal antibodies in a cohort of 68 mammary carcinomas which had also been analyzed f 11964043 Human
cyclin e mammary carcinomas In order to further analyze the role of CEACAM1 in the development of breast cancer, we performed Western-blot analysis and immunohistochemistry with highly specific monoclonal antibodies in a cohort of 68 mammary carcinomas which had also been analyzed f 11964043 Human
cyclin e tumors CBP-null tumors show reduced levels of p27Kip1 and increased levels of cyclin E and Skp2, two oncoproteins that can promote p27Kip1 proteolysis. 14998493 Human
cyclin e retinoblastoma RESULTS: The summary of our findings indicates that (a). these cells from chemically induced rat prostate tumors express COX-2 at both the mRNA and the protein level; (b). celecoxib significantly reduces COX-2 expression in these cancer cells; and (c). ce 12960143 Human
cyclin e breast cancer Cyclin E is overexpressed and proteolytically cleaved into low molecular weight (LMW) isoforms in breast cancer cell lines and tumor tissues compared to normal cells and tissues. 12963845 Human
cyclin e tumor Cyclin E is overexpressed and proteolytically cleaved into low molecular weight (LMW) isoforms in breast cancer cell lines and tumor tissues compared to normal cells and tissues. 12963845 Human
cyclin e breast cancer These alterations in cyclin E are linked to poor prognosis in breast cancer patients. 12963845 Human
cyclin e breast cancers Dysregulated cyclin E expression is found in nearly all breast cancers examined. 12009211 Human
cyclin e breast cancer Toward the goal of developing a system to block cyclin E function in normal and breast cancer cells, we have developed anti-cyclin E single-chain antibodies (sFvs) for use as intrabodies. 12009211 Human
cyclin e other cancers This work sets the stage for the development of intrabody-based inducible or tissue-specific cyclin E knockouts and for identifying cyclin E and its vital cell cycle functions as a potential gene therapy target in breast and other cancers. 12009211 Human
cyclin e primary tumor To examine the hypothesis that abnormal cell-cycle regulators act as the mutators contributing to genomic instability, the present study, based on primary tumor tissues from 71 patients with breast cancer, was performed to determine whether there was an a 12007188 Human
cyclin e breast cancer To examine the hypothesis that abnormal cell-cycle regulators act as the mutators contributing to genomic instability, the present study, based on primary tumor tissues from 71 patients with breast cancer, was performed to determine whether there was an a 12007188 Human
ccne1 primary tumors Expression of cyclin E gene (CCNE1) correlated closely with that of TFDP1 in not only cell lines, but also primary tumors. 12029633 Human
cyclin e primary tumors Expression of cyclin E gene (CCNE1) correlated closely with that of TFDP1 in not only cell lines, but also primary tumors. 12029633 Human
cyclin e colorectal cancer Cyclin E and chromosome instability in colorectal cancer cell lines. 12032232 Human
cyclin e cancer Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. 12032232 Human
cyclin e colorectal cancer METHODS: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. 12032232 Human
cyclin e tumors Our findings suggest that in corticotroph tumors there is an accentuated phosphorylation of p27 into P-p27, possibly related to increased cyclin E expression, whereas both p27 and P-p27 are subject to increased degradation in pituitary carcinomas. 12050228 Human
cyclin e carcinomas Our findings suggest that in corticotroph tumors there is an accentuated phosphorylation of p27 into P-p27, possibly related to increased cyclin E expression, whereas both p27 and P-p27 are subject to increased degradation in pituitary carcinomas. 12050228 Human
cyclin e gastric cancer The aim of this study was to investigate the expression of D-type cyclins and cyclin E in gastric cancer patients (N = 34), in healthy first-degree relatives of gastric cancer patients (N = 29), and in control subjects (N = 18). 12064799 Human
cyclin e breast cancer The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node. 12096344 Human
cyclin e tumours Increased proliferation was observed in two different scenarios; (1) with high cyclin D1 and elevated retinoblastoma protein (pRb) phosphorylation, (cyclin D1(high) tumours) or (2) with high cyclin E protein but low cyclin D1 and lack of corresponding pRb 12096344 Human
cyclin e retinoblastoma Increased proliferation was observed in two different scenarios; (1) with high cyclin D1 and elevated retinoblastoma protein (pRb) phosphorylation, (cyclin D1(high) tumours) or (2) with high cyclin E protein but low cyclin D1 and lack of corresponding pRb 12096344 Human
cyclin e tumours Using transfected cell lines overexpressing cyclin E, cyclin E(high) and D1(high) tumours were mimicked and the cyclin D1(high) cell line normalized the cyclin E kinase activity by an induction and redirection of p21 and p27 to the cyclin E complex wherea 12096344 Human
cyclin e breast cancers Cyclin E, a key mediator of entry into the cell division cycle, is expressed abundantly in many breast cancers. 12100739 Human
cyclin e breast cancer In a recent report, Steve Reed's lab demonstrates that hCdc4/Fbw7 targets cyclin E for ubiquitin-mediated proteolysis and is mutant in a breast cancer cell line with high cyclin E levels. 12100739 Human
cyclin e breast cancer These results suggest that lesions in protein degradation pathways may contribute to cyclin E deregulation in breast cancer. 12100739 Human
cyclin e breast cancer Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. 14701826 Human
cyclin e breast cancer We have reported previously that cyclin E is overexpressed in breast cancer and such overexpression is usually accompanied by the appearance of low molecular weight isoforms of cyclin E protein, which are not present in normal cells. 14701826 Human
cyclin e breast cancer Furthermore, we have shown that the expression of cyclin E low molecular weight isoforms can be used as a reliable prognostic marker for breast cancer to predict patient outcome. 14701826 Human
cyclin e cancer For this purpose, a series of N-terminal deleted forms of cyclin E corresponding to the low molecular weight forms detected only in cancer cells were translated in vitro and mixed with cell extracts. 14701826 Human
cyclin e tumor Addition of cyclin E into both normal and tumor cell extracts was shown to increase the levels of CDK2 activity, along with an increase in the amount of phosphorylated CDK2. 14701826 Human
cyclin e tumor Our data suggest that the ability of high levels of full-length and low molecular weight forms of cyclin E to activate CDK2 may be one mechanism that leads to the constitutive activation of cyclin E.CDK2 complexes leading to G(1)/S deregulation and tumor 14701826 Human
cyclin e tumor Different cyclin E proteins are present in tumor tissues but absent from normal (steady) tissues. 12135897 Human
cyclin e tumor Both placental and tumor tissues showed seven cyclin E low molecular weight (LMW) bands migrating between 50 and 36 kDa. 12135897 Human
cyclin e tumor Our studies indicate that a similar spectrum of cyclin E protein variants is expressed in the placental and tumor tissues. 12135897 Human
cyclin e breast cancer During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/Cip1), was increased in a time-dependent manner in a breast cancer cell MCF-7. 12150857 Human
cyclin e tumours Overexpressed cyclin E in tumours is a prognosticator for poor patient outcome. 12163026 Human
cyclin e cancers Cells that overexpress cyclin E have been shown to be impaired in S-phase progression and exhibit genetic instability that may drive this subset of cancers. 12163026 Human
cyclin e leukemia Furthermore, we found that cyclin E + A/DNA multiparameter flow cytometry could also be used for stathmokinetic analysis of lymphocyte leukemia MOLT-4 cells after addition of the stathmokinetic agent vinblastine to cultures of exponentially growing MOLT-4 12168070 Human
cyclin e human tumors However, in many types of human tumors cyclin E protein is elevated and deregulated relative to the cell cycle by an unknown mechanism. 12183400 Human
cyclin e endometrial tumors Here, we show that the F-box protein hCdc4 that targets cyclin E to the SCF (Skp1-Cull-F-box) protein ubiquitin ligase is mutated in at least 16% of human endometrial tumors. 12183400 Human
cyclin e murine mammary tumor Further optimization led to compounds such as water soluble 45, which possesses a favorable pharmacokinetic profile in mice and demonstrates significant antitumor activity in vivo in several murine and human models, including an engineered murine mammary 12190313 Human
cyclin e primary carcinomas To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e metastases To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e adenomas To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e hyperplastic polyps To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e hepatic metastases To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e tumours To clarify the expression of p107 in colorectal tumours, 22 normal mucosae, 9 hyperplastic polyps, 60 adenomas, 198 primary carcinomas, 21 lymph-nodal metastases, and 10 hepatic metastases were immunohistochemically stained for p107, cyclin A, cyclin E, C 12204665 Human
cyclin e adenomas As the p107 LI gradually rose, the CDK2 (in primary cancers only), cyclin A, cyclin E and Ki67 LIs were elevated concurrently-in both adenomas and primary cancers. 12204665 Human
cyclin e primary cancers As the p107 LI gradually rose, the CDK2 (in primary cancers only), cyclin A, cyclin E and Ki67 LIs were elevated concurrently-in both adenomas and primary cancers. 12204665 Human
cyclin e cancer Cyclin E is overexpressed in cancer, suggesting that cyclin E/CDK2 deregulation contributes to tumorigenesis. 14522248 Human
cyclin e tumor Both unregulated Notch and cyclin E promote tumorigenesis, and inactivating mutations in human Fbw7 suggest that it may be a tumor suppressor. 14766969 Human
cyclin e breast carcinoma Furthermore, the breast carcinoma cells exhibited lower cyclin D1 and cyclin E levels but higher cyclin B1 level after incubation with the CHL showing that these cyclin changes may be important for the antiproliferative effect of the CHL. 12888910 Human
cyclin e endometrial cancer A significantly higher amount of cyclin E staining was observed in endometrial cancer tissues from postmenopausal women than in normal postmenopausal endometrium (p=0.017). 12239611 Human
cyclin e endometrial cancers There was a positive significant correlation between cyclin E and CDK2 expression levels in endometrial cancers (p<0.05). 12239611 Human
cyclin e endometrial cancers No significant relationship was found between telomerase activity and its association with p27 and cyclin E expression in endometrial cancers. 12239611 Human
cyclin e endometrial cancer In addition, increased cyclin E expression may play an important role in endometrial cancer development in postmenopausal women. 12239611 Human
cyclin e carcinoma METHODOLOGY: Using immunohistochemistry, we investigated the expression of p21WAF1/CIP1, p27Kip1, p16INK4, cyclin D1, cyclin E, pRb and p53 in 14 resected specimens of ampullary carcinoma and defined the proliferative activity of each tumor by quantifying 12239913 Human
cyclin e tumor METHODOLOGY: Using immunohistochemistry, we investigated the expression of p21WAF1/CIP1, p27Kip1, p16INK4, cyclin D1, cyclin E, pRb and p53 in 14 resected specimens of ampullary carcinoma and defined the proliferative activity of each tumor by quantifying 12239913 Human
cyclin e tumors Four tumors (29%) overexpressed cyclin D1 and 8 (57%) overexpressed cyclin E. 12239913 Human
cyclin e tumors The proliferative index was higher in tumors with decreased p27Kip expression (P = 0.005), and in tumors with cyclin E overexpression (P = 0.06). 12239913 Human
cyclin e prostate carcinoma We tested whether vitamin E induces cell cycle arrest in prostate carcinoma, mediated by alterations in cell cycle regulatory proteins, including cyclin E, cdk2 and p27. 12352461 Human
cyclin e colorectal carcinoma Overexpression of cyclin E protein is closely related to the mutator phenotype of colorectal carcinoma. 12355212 Human
cyclin e kidney cancer The overexpression of cyclin E in a variety of human cancers, for example in colorectal, gastric, lung, breast, and kidney cancer, provides evidence that cyclin E plays a pivotal role in the cell cycle and replication. 12355212 Human
cyclin e cancers The overexpression of cyclin E in a variety of human cancers, for example in colorectal, gastric, lung, breast, and kidney cancer, provides evidence that cyclin E plays a pivotal role in the cell cycle and replication. 12355212 Human
cyclin e colorectal carcinomas We examined whether the overexpression of cyclin E is related to the status of the mismatch repair system in colorectal carcinomas. 12355212 Human
cyclin e tumors RESULTS: High microsatellite instability was detected in 13 tumors, and in 10 of these (77%) cyclin E protein was overexpressed at least twofold compared to normal mucosa. 12355212 Human
cyclin e tumors In contrast, only 28 of the remaining 87 microsatellite stable tumors (32%) overexpressed cyclin E. 12355212 Human
cyclin e carcinoma Lower molecular weight cyclin E proteins were present in 7 of 87 microsatellite stable carcinoma (8%), compared to 7 cases exhibiting lower molecular weight isoforms of 13 MSI carcinoma (54%). 12355212 Human
cyclin e colorectal tumors CONCLUSION: Increased cyclin E protein expression and the appearance of lower molecular weight cyclin E proteins were significantly associated with MSI in colorectal tumors. 12355212 Human
cyclin e colorectal cancer The data indicate that increased and/or aberrant expression of cyclin E protein might contribute to the mutator phenotype of colorectal cancer. 12355212 Human
cyclin e t-cell lymphomas In addition, we demonstrated that high level cyclin E expression potentiates the development of methyl-nitroso-urea-induced T-cell lymphomas in mice. 12149264 Human
cyclin e tumor The cyclin E promoter was activated by p300 and the histone deacetylase inhibitor trichostatin A. Conversely, the cyclin E promoter was repressed by wild-type Retinoblastoma tumor suppressor p105 protein (pRB) and by a dominant negative p300 mutant (DN p3 12414652 Human
cyclin e melanoma The biological significance of these results was established by showing that block of p300 activity by overexpression of DN p300 or by Lys-CoA, a specific chemical inhibitor of p300, resulted in growth inhibition, down-regulation of cyclin E, and activati 12414652 Human
cyclin e cancer Loss of this response may thus be required before deregulated cyclin E can become fully oncogenic in cancer cells. 12419181 Human
cyclin e breast cancer Cyclin E and prognosis in patients with breast cancer. 12432040 Human
cyclin e breast cancer Cyclin E and survival in patients with breast cancer. 12432043 Human
cyclin e breast cancer We investigated whether levels of cyclin E in the tumor correlated with survival among patients with breast cancer. 12432043 Human
cyclin e tumor We investigated whether levels of cyclin E in the tumor correlated with survival among patients with breast cancer. 12432043 Human
cyclin e breast cancer METHODS: Tumor tissue from 395 patients with breast cancer was assayed for cyclin E, cyclin D1, cyclin D3, and the HER-2/neu oncogene with the use of Western blot analysis. 12432043 Human
cyclin e tumor METHODS: Tumor tissue from 395 patients with breast cancer was assayed for cyclin E, cyclin D1, cyclin D3, and the HER-2/neu oncogene with the use of Western blot analysis. 12432043 Human
cyclin e tumors Immunohistochemical assessments of cyclin E were also made of 256 tumors. 12432043 Human
cyclin e metastases A high level of the low-molecular-weight isoforms of cyclin E, as detected by Western blotting, correlated strongly with disease-specific survival whether axillary lymph nodes were negative or positive for metastases (P<0.001). 12432043 Human
cyclin e breast cancer Among 114 patients with stage I breast cancer, none of the 102 patients with low levels of cyclin E in the tumor had died of breast cancer by five years after diagnosis, whereas all 12 patients with a high level of low-molecular-weight cyclin E had died o 12432043 Human
cyclin e stage i breast cancer Among 114 patients with stage I breast cancer, none of the 102 patients with low levels of cyclin E in the tumor had died of breast cancer by five years after diagnosis, whereas all 12 patients with a high level of low-molecular-weight cyclin E had died o 12432043 Human
cyclin e tumor Among 114 patients with stage I breast cancer, none of the 102 patients with low levels of cyclin E in the tumor had died of breast cancer by five years after diagnosis, whereas all 12 patients with a high level of low-molecular-weight cyclin E had died o 12432043 Human
cyclin e breast cancer The hazard ratio for death from breast cancer for patients with high total cyclin E levels as compared with those with low total cyclin E levels was 13.3--about eight times as high as the hazard ratios associated with other independent clinical and pathol 12432043 Human
cyclin e breast cancer CONCLUSIONS: Levels of total cyclin E and low-molecular-weight cyclin E in tumor tissue, as measured by Western blot assay, correlate strongly with survival in patients with breast cancer. 12432043 Human
cyclin e tumor CONCLUSIONS: Levels of total cyclin E and low-molecular-weight cyclin E in tumor tissue, as measured by Western blot assay, correlate strongly with survival in patients with breast cancer. 12432043 Human
cyclin e tumor Results indicated that the levels of cyclin E mRNA in various tumor cells were decreased by panaxynol. 12449728 Human
cyclin e tumor Thus, the suppressant effects of panaxynol on proliferation of various tumor cells appeared to be mediated, at least in part, through impairments of cyclin E mRNA levels and arresting cell cycle progression in the cells. 12449728 Human
cyclin e human renal-cell carcinoma Cyclin E and p27 protein content in human renal cell carcinoma: clinical outcome and associations with cyclin D. 12448001 Human
cyclin e tumors Most of the tumors (65%) exhibited higher cyclin E levels than corresponding normal kidney cortex tissues. 12448001 Human
cyclin e tumors However, only a small fraction of the tumors (3 of 80) had excessive levels of cyclin E when cyclin E levels were compared with proliferation. 12448001 Human
cyclin e tumor In summary, the results suggest that protein expression of cyclin E and/or p27 is linked to tumor behavior. 12448001 Human
cyclin e testicular germ-cell tumors p27 and cyclin E/D2 associations in testicular germ cell tumors: implications for tumorigenesis. 12777997 Human
cyclin e tumors We have previously shown that in testicular germ cell tumors, cyclin E expression correlates with more aggressive tumors, higher clinical stage, and the presence of pulmonary metastases. 12777997 Human
cyclin e testicular germ-cell tumors We have previously shown that in testicular germ cell tumors, cyclin E expression correlates with more aggressive tumors, higher clinical stage, and the presence of pulmonary metastases. 12777997 Human
cyclin e pulmonary metastases We have previously shown that in testicular germ cell tumors, cyclin E expression correlates with more aggressive tumors, higher clinical stage, and the presence of pulmonary metastases. 12777997 Human
cyclin e embryonal carcinomas We have shown that in a panel of 30 testicular germ cell tumors, 15 cases (50%) expressed the cyclin dependent kinase inhibitor p27; of note, 13 of 14 embryonal carcinomas (93%) coexpressed cyclin E and p27, suggesting inhibition of this cyclin. 12777997 Human
cyclin e testicular germ-cell tumors We have shown that in a panel of 30 testicular germ cell tumors, 15 cases (50%) expressed the cyclin dependent kinase inhibitor p27; of note, 13 of 14 embryonal carcinomas (93%) coexpressed cyclin E and p27, suggesting inhibition of this cyclin. 12777997 Human
cyclin e embryonal carcinoma Using immunoprecipitation assays from the embryonal carcinoma cell line NTera2 or from tumor cell extracts, we have shown that cyclin D2 is complexed with p27, consistent with its known ability to sequester and block the cyclin E inhibitory function of p2 12777997 Human
cyclin e tumor Using immunoprecipitation assays from the embryonal carcinoma cell line NTera2 or from tumor cell extracts, we have shown that cyclin D2 is complexed with p27, consistent with its known ability to sequester and block the cyclin E inhibitory function of p2 12777997 Human
cyclin e embryonal carcinomas From these results, we propose a model in testicular germ cell tumors, in particular embryonal carcinomas, whereby the overexpression of cyclin D2, a gene localized on chromosome 12p--a region of DNA amplification in germ cell tumors--leads to the functio 12777997 Human
cyclin e testicular germ-cell tumors From these results, we propose a model in testicular germ cell tumors, in particular embryonal carcinomas, whereby the overexpression of cyclin D2, a gene localized on chromosome 12p--a region of DNA amplification in germ cell tumors--leads to the functio 12777997 Human
cyclin e germ-cell tumors From these results, we propose a model in testicular germ cell tumors, in particular embryonal carcinomas, whereby the overexpression of cyclin D2, a gene localized on chromosome 12p--a region of DNA amplification in germ cell tumors--leads to the functio 12777997 Human
cyclin e breast cancer Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells. 12460907 Human
cyclin e breast cancers Cyclin D1 and cyclin E are overexpressed in approximately 45% and 30% of breast cancers, respectively, and adverse associations with patient outcome have been reported. 12460907 Human
cyclin e breast cancer The potential roles of cyclin D1 and cyclin E expression as markers of therapeutic responsiveness to the pure steroidal antiestrogen ICI 182780 were investigated using T-47D breast cancer cell lines constitutively overexpressing cyclin D1 or cyclin E. 12460907 Human
cyclin e1 breast tumor The levels of cyclin E1 and cyclin E2 were significantly elevated (23 vs 38%, respectively) in primary breast tumor samples relative to normal breast tissue controls. 12466974 Human
cyclin e1 breast tumors We also observed an inverse correlation between the expression of cyclin E1/E2 and estrogen receptor in breast tumors. 12466974 Human
cyclin e1 breast tumors Our results demonstrate that the expression and associated catalytic activity for both cyclin E1 and cyclin E2 is elevated in primary breast tumors when compared to normal breast tissue. 12466974 Human
cyclin e1 breast tumors The increased level of cyclin E2 in breast tumors suggests that, similar to cyclin E1, it may contribute to the pathogenesis of breast cancer. 12466974 Human
cyclin e1 breast cancer The increased level of cyclin E2 in breast tumors suggests that, similar to cyclin E1, it may contribute to the pathogenesis of breast cancer. 12466974 Human
cyclin e cholangiocarcinoma Apoptosis and cell cycles in the cholangiocarcinoma cell lines after OCT administration were evaluated by flow cytometry; and the effects of OCT on the expression of cyclin E, cyclin-dependent kinase 2 (CDK2), and p27kipl were evaluated by Western blots. 12483273 Human
cyclin e non-small cell lung cancer Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases. 12494250 Human
cyclin e lymph-node metastases Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases. 12494250 Human
cyclin e cancer BACKGROUND: Cyclin E and p27 play pivotal roles in cancer development and progression. 12494250 Human
cyclin e non-small cell lung cancer We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. 12494250 Human
cyclin e lymph-node metastases We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. 12494250 Human
cyclin e tumors METHODS: Tumors from 62 patients at least 5 years after surgery were assessed by immunohistochemistry for expression of cyclin E, p27, and Ki-67. 12494250 Human
cyclin e tumor CONCLUSION: By analyzing the expression of cyclin E, p27, and Ki-67 of tumor cells, it was possible to extract the patient group for whom closer follow-up and postoperative treatment is necessary to improve survival rate. 12494250 Human
cyclin e hepatocellular carcinoma Expression of p33(ING1) in hepatocellular carcinoma: relationships to tumour differentiation and cyclin E kinase activity. 12523595 Human
cyclin e tumour Expression of p33(ING1) in hepatocellular carcinoma: relationships to tumour differentiation and cyclin E kinase activity. 12523595 Human
cyclin e tumor Low p57kip2 expression was significantly associated with high tumor grades, advanced clinical stages and cyclin E overexpression. 12530064 Human
cyclin e tumor Our findings indicated that high expression of p27 throughout the G1 to S phase may inhibit more likely cyclin E, than cyclin D1, which promotes tumor growth of esophageal squamous cell carcinoma. 11115553 Human
cyclin e esophageal squamous-cell carcinoma Our findings indicated that high expression of p27 throughout the G1 to S phase may inhibit more likely cyclin E, than cyclin D1, which promotes tumor growth of esophageal squamous cell carcinoma. 11115553 Human
cyclin e human squamous cell carcinoma To determine the crucial abnormality in the cell cycle regulatory proteins in human squamous cell carcinoma of the esophagus, we examined the cell growth ratio (CGR) and basal expression levels of G1 cyclins (cyclin D1, cyclin E), cyclin-dependent kinase 11115554 Human
cyclin e metastasis Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. 11212263 Human
cyclin e non-small cell lung cancer Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer. 11212263 Human
cyclin e cancers Two of these, cyclin E and cyclin A2 (also known as cyclin A), are overexpressed in many cancers. 11212263 Human
cyclin e tumor Expression levels of cyclin E (P = 0.04) and cyclin A2 (P = 0.004) were significantly higher in the tumor samples than in normal controls. 11212263 Human
cyclin e metastasis Cyclin E was also closely associated with the development of distant metastasis (P = 0.01). 11212263 Human
cyclin e cervical adenocarcinomas STUDY DESIGN: Fifty-five in situ and invasive cervical adenocarcinomas were compared with 5 normal endocervical controls by immunohistochemical analysis of p16, p21, p27, cyclin D1, cyclin E, p53, and Ki-67. 15041997 Human
cyclin e breast ductal carcinoma Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications. 11172300 Human
cyclin e cancers Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. 11172300 Human
cyclin e breast ductal carcinomas To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 157 mastectomy and axillary clearance specimens were stained with the cyclin E antibody. 11172300 Human
cyclin e non-small cell lung cancers Expression of cyclin E and cyclin D1 in non-small cell lung cancers. 11162860 Human
cyclin e non-small cell lung cancers The relationships between overexpression of cyclin D1 or cyclin E and clinicopathological factors were investigated in 157 patients with non-small cell lung cancers (NSCLCs) using immunohistochemical analysis. 11162860 Human
cyclin e adenocarcinoma Overexpression of cyclin E was more frequently observed in squamous cell carcinoma (29/57, 51%) compared with that in adenocarcinoma (28/86, 33%) (P<0.05). 11162860 Human
cyclin e squamous-cell carcinoma Overexpression of cyclin E was more frequently observed in squamous cell carcinoma (29/57, 51%) compared with that in adenocarcinoma (28/86, 33%) (P<0.05). 11162860 Human
cyclin e tumor These findings suggest that expression of cyclin E was frequently independent of that of cyclin D1 and played some roles in the grade of tumor differentiation in NSCLCs. 11162860 Human
cyclin e human lung cancer Upon transduction of several human lung cancer cells with ad-p27, a high level of p27 expression, with a decrease in cdk2 and an increase in cyclin E were observed. 11165393 Human
cyclin e bladder cancer Intranuclear compartmentalization of cyclin E during the cell cycle: disruption of the nucleoplasm-nucleolar shuttling of cyclin E in bladder cancer. 11221854 Human
cyclin e bladder cancer Laser scanning cytometry, a microscope-based cytofluorometer combining the advantages of both flow and image analysis, allowed the determination of subcellular localization of cyclin E, p27, and retinoblastoma protein during cell cycle progression in norm 11221854 Human
cyclin e retinoblastoma Laser scanning cytometry, a microscope-based cytofluorometer combining the advantages of both flow and image analysis, allowed the determination of subcellular localization of cyclin E, p27, and retinoblastoma protein during cell cycle progression in norm 11221854 Human
cyclin e tumor We observed that in normal fibroblasts and most tumor cell lines, cyclin E localizes in the nucleoplasm during mid-G1, and is translocated to the nucleolus during G1-S-phase transition, and its levels are undetectable in G2-M phase. 11221854 Human
cyclin e bladder cancer However, four of nine bladder cancer cell lines continued to express cyclin E in all phases of the cycle, and image analysis revealed that it was localized to nucleoli. 11221854 Human
cyclin e bladder cancer These observations suggest that the nucleolus mediates a cyclin E "shuttling" between the nucleus and the cytoplasm that is probably involved in its regulation and that this mechanism could be disrupted in bladder cancer. 11221854 Human
cyclin e colonic cancer Up-regulation of nm23, TIMP1, VEGF, and cyclin E and down-regulation of some tumor suppressor genes (p53, TOSO, and SIVA), beta-catenin, and metallothionein were observed in colonic cancer specimen when compared with those of normal mucosa. 11227951 Human
cyclin e cervical cancer This review surveys recent advances in this field, summarizing the advantages and limitations of several candidate biomarkers, including PCNA, Ki-67, cyclin E, p16ink4, MN antigen, carcinoembryonic antigen (CEA), and telomerase in the recognition of prein 11236957 Human
cyclin e gastric adenocarcinomas Reactivation of telomerase, inactivation of p53 tumor suppressor gene, overexpression of cyclin E, and reduced expression of p27 KIP1 by disorganized degradation in proteasome are common events of both well-differentiated and poorly differentiated gastric 11243597 Human
cyclin e cutaneous melanomas RESULTS: Cyclin E and CDK2 had the highest expression patterns in human cutaneous melanomas and metastases and correlated positively with histological type and tumour stage. 11253137 Human
cyclin e metastases RESULTS: Cyclin E and CDK2 had the highest expression patterns in human cutaneous melanomas and metastases and correlated positively with histological type and tumour stage. 11253137 Human
cyclin e tumour RESULTS: Cyclin E and CDK2 had the highest expression patterns in human cutaneous melanomas and metastases and correlated positively with histological type and tumour stage. 11253137 Human
cyclin e malignant melanomas CONCLUSIONS: Taken together, this study demonstrated a significant increase of cyclin E and CDK2 expression during tumour progression in malignant melanomas. 11253137 Human
cyclin e tumour CONCLUSIONS: Taken together, this study demonstrated a significant increase of cyclin E and CDK2 expression during tumour progression in malignant melanomas. 11253137 Human
cyclin e non-small cell lung cancers A risk-stratification model of non-small cell lung cancers using cyclin E, Ki-67, and ras p21: different roles of G1 cyclins in cell proliferation and prognosis. 11289121 Human
cyclin e cancer In the present study, we have characterized expression of cyclin D1 and cyclin E in a cohort of 217 resected NSCLCs from a single institution by immunohistochemistry to analyze their expression in relation to the growth fraction determined by Ki-67 and to 11289121 Human
cyclin e tumors Tumors having high-level cyclin E expression (cyclin E LI > or =30%) showed a significantly higher Ki-67 LI than tumors having low-level cyclin E expression (cyclin E LI <30%; P < 0.001), whereas positive or negative cyclin D1 expression was not associate 11289121 Human
ccne lymphomas To compare the expression status of G1 cyclins, these EBV-associated lymphoma lines (6 EBV[-] human SCID mouse lymphoma lines, 13 human B cell lymphomas and 8 samples of human tonsil tissue) were examined by reverse transcription-polymerase chain reaction 11291051 Human
cyclin e lymphomas To compare the expression status of G1 cyclins, these EBV-associated lymphoma lines (6 EBV[-] human SCID mouse lymphoma lines, 13 human B cell lymphomas and 8 samples of human tonsil tissue) were examined by reverse transcription-polymerase chain reaction 11291051 Human
ccne mouse lymphoma CCNE was positive in the nuclei in all EBV(+) but negative in all EBV(-) SCID mouse lymphoma lines. 11291051 Human
ccne mouse lymphomas Immunoprecipitation of EBV(+) and (-) SCID mouse lymphomas for CCND1, CCND2 and CCNE vs. p21, PCNA and CDK2 or CDK4 demonstrated that, in EBV(+) SCID lines, CCND2/CDK4 complexes were present without binding to p21, suggesting independence from p21 regulat 11291051 Human
ccne lymphomas In contrast, CCND1/CDK4 and CCNE/CDK2 were under regulation of p21 in both EBV(+) and (-) lymphomas. 11291051 Human
ccne lymphomas These results suggest that differential expression of CCNDs, CCNE and CDKs, as well as variation in their subcellular localization and association with CDK-inhibitor protein, could explain differences in cell proliferation between EBV(+) and EBV(-) lympho 11291051 Human
cyclin e retinoblastoma To determine the inhibitory pathway of cGMP-protein kinase G in cultured mesangial cells, we investigated the effects of cGMP- and adenovirus-mediated overexpression of protein kinase G on the promoter activities of cyclin E, cyclin D1, and cyclin A. 8-Br 11292628 Human
cyclin e human hepatocellular carcinomas Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. 11299822 Human
cyclin e cancer Thus, the HCCs with enhanced cyclin E expression probably contain a relatively large number of proliferating cancer cells. 11299822 Human
cyclin e hyperplasia Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2. 11313930 Human
cyclin e hyperplasia Furthermore, transfection of hepatocytes in vivo with cyclin E and skp2 promoted abundant hepatocyte replication and hyperplasia of the liver. 11313930 Human
cyclin e intestinal-type gastric cancer In addition to these events, p53 mutation and loss of heterozygosity (LOH), reduced p27 expression, cyclin E expression and the presence of c-met 6.0-kb transcripts allow malignant transformation from the above precancerous lesions to intestinal-type gast 15055305 Human
cyclin e human ovarian cancer Inactivation of the tumor suppressor gene and deregulation of cyclin E are frequent in human ovarian cancer. 12713563 Human
cyclin e ovarian tumors The objective of this study was to investigate the expressions and roles of cyclin E, p21 and p27 in 7, 12-dimethylbenzanthracene (DMBA)-induced ovarian tumors in rats. 12713563 Human
cyclin e ovarian tumors The expressions of cyclin E and p21 in ovarian tumors was higher than that in normal ovarian surface epithelium. 12713563 Human
cyclin e tumor These results suggest that the increased expression of cyclin E and p21, and the decreased expression of p27, occur in DMBA-induced rat ovarian carcinogenesis and result in tumor progression. 12713563 Human
cyclin e wilms tumor METHODS: We examined expression patterns of cyclin D1; cyclin E; cyclin A; cyclin B1; cyclin-dependent kinase (CDK)2; CDK4; such CDK inhibitors as p21WAF1/CIP1 (p21), p27kip1 (p27), and p57kip2 (p57); and Wilms' tumor protein-1 (WT-1) in 12 renal bio 14712423 Human
cyclin e human breast cancer Overexpression of cyclin E protein is associated with specific mutation types in the p53 gene and poor survival in human breast cancer. 14633656 Human
cyclin e breast cancers To explore potential associations between cyclin E deregulation and inactivation of the p53 tumor suppressor gene in human breast cancer, we investigated the immunohistochemical expression of cyclin E in paraffin embedded breast cancers from 270 women wit 14633656 Human
cyclin e tumor To explore potential associations between cyclin E deregulation and inactivation of the p53 tumor suppressor gene in human breast cancer, we investigated the immunohistochemical expression of cyclin E in paraffin embedded breast cancers from 270 women wit 14633656 Human
cyclin e human breast cancer To explore potential associations between cyclin E deregulation and inactivation of the p53 tumor suppressor gene in human breast cancer, we investigated the immunohistochemical expression of cyclin E in paraffin embedded breast cancers from 270 women wit 14633656 Human
cyclin e breast cancers Fifty-six percent (15/27) of the breast cancers with high cyclin E had p53 gene mutations, compared with 14% (24/171) of those with low cyclin E content (P < 0.0001). 14633656 Human
cyclin e breast cancers In p53 mutated breast cancers high cyclin E content was associated with insertions, deletions and nonsense point mutations in the p53 tumor suppressor gene, whereas low cyclin E was linked to p53 missense point mutations. 14633656 Human
cyclin e metastases We also observed statistically significant associations between a high cyclin E content and aneuploidy, high S phase, larger tumor size, estrogen receptor negativity, presence of axillary node metastases and high tumor grade. 14633656 Human
cyclin e tumor We also observed statistically significant associations between a high cyclin E content and aneuploidy, high S phase, larger tumor size, estrogen receptor negativity, presence of axillary node metastases and high tumor grade. 14633656 Human
cyclin e tumor In summary, our findings demonstrate that overexpression of cyclin E is associated with an aggressive tumor phenotype and specific types of p53 mutations. 14633656 Human
cyclin e invasive bladder cancer Decreasing of p27(Kip1)and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer. 11336477 Human
cyclin e transitional cell carcinoma We studied the relationship between protein levels of p27, cyclin E and Ki-67 and clinicopathological features of 145 consecutive Japanese patients with transitional cell carcinoma of the bladder using immunohistochemical staining. 11336477 Human
cyclin e tumours Among the recurrenced superficial tumours (35 patients), the tumours which remained at a low stage showed high protein levels of p27 and cyclin E, and the tumours which progressed to invasive disease showed a gradual decrease in p27 and cyclin E protein l 11336477 Human
cyclin e bladder cancer Our findings suggest that decreased protein levels of p27 and cyclin E play a role in the progression of bladder cancer and to evaluate these protein levels may be useful in management of the diseases. 11336477 Human
cyclin e hepatocellular carcinomas Microsatellite instability correlates with normal expression of cyclin E in hepatocellular carcinomas. 11351261 Human
cyclin e hepatocellular carcinomas In the present study, we studied the incidence of MSI at 5 polymorphic microsatellite markers (D5S406, D13S153, D16S402, D17S796, and poly(A) tract BAT26), the expression of G1 cyclins (cyclin A, cyclin D and cyclin E), and Ki-67 labeling index in 30 surg 11351261 Human
cyclin e tumor Cyclin E and p27Kip1 are co-regulators of the G1- to S-phase transition and closely related to tumor behavior. 11355304 Human
cyclin e astrocytoma The purpose of this study was to examine expression of cyclin E and p27Kip1 in astrocytomas and to evaluate the relationships between expression of these cell-cycle regulators and prognosis of patients with astrocytoma. 11355304 Human
cyclin e tumor The cyclin E labeling index (LI) tended to increase with tumor grade (Kruskal-Wallis, P = 0.0104). 11355304 Human
cyclin e astrocytoma This study suggested that combined analysis of cyclin E and p27Kip1 expression was considered to be potentially useful in predicting the prognosis of patients with astrocytoma. 11355304 Human
cyclin e testicular germ-cell tumors Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. 11358847 Human
cyclin e tumors CDK2 and its catalytic partner cyclin E were down-regulated in 40% (19 of 47) and 42% (19 of 45) of the tumors, respectively, by a factor of 7 each. 11358847 Human
cyclin e tumors Western blots and immunohistochemical experiments confirmed cyclin D2 and CDK4 overrepresentation and reduced expression of cyclin E and CDK2 tumors in the few tumors under protein study. 11358847 Human
cyclin e tumors Because up-regulation of the cyclin D2/CDK4 complex and down-regulation of cyclin E/CDK2 complex were found in seminomas as well as in non-seminomas and in all tumor stages, these findings seem to be early events during tumorigenesis of testicular GCTS: T 11358847 Human
cyclin e germ-cell tumors Because up-regulation of the cyclin D2/CDK4 complex and down-regulation of cyclin E/CDK2 complex were found in seminomas as well as in non-seminomas and in all tumor stages, these findings seem to be early events during tumorigenesis of testicular GCTS: T 11358847 Human
cyclin e tumor Because up-regulation of the cyclin D2/CDK4 complex and down-regulation of cyclin E/CDK2 complex were found in seminomas as well as in non-seminomas and in all tumor stages, these findings seem to be early events during tumorigenesis of testicular GCTS: T 11358847 Human
cyclin e hepatocellular carcinoma Reciprocal expressions of cyclin E and cyclin D1 in hepatocellular carcinoma. 11368878 Human
cyclin e cancer Deregulation of the cell cycle by overexpression of G1 cyclins, cyclin E and cyclin D1 genes, has been demonstrated to be a prerequisite for the development of human cancer. 11368878 Human
cyclin e retinoblastoma Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB). 11376126 Human
cyclin e epithelial ovarian cancers Cyclin E mRNA overexpression in epithelial ovarian cancers: inverse correlation with p53 protein accumulation. 11390254 Human
cyclin e epithelial ovarian cancers OBJECTIVE:We investigated the relationship between cyclin E mRNA overexpression and p53 protein accumulation in epithelial ovarian cancers. 11390254 Human
cyclin e ovarian cancer Cyclin E and p53 protein expression in ovarian cancer tissues were examined by immunohistochemistry using the same series of samples. 11390254 Human
cyclin e ovarian tumor RESULTS: Considerable levels of cyclin E mRNA were detected in all normal ovaries and ovarian tumor samples examined by semiquantitative PCR amplification. mRNA levels of cyclin E were significantly higher in nine of 30 (30%) ovarian cancers compared with 11390254 Human
cyclin e ovarian cancers RESULTS: Considerable levels of cyclin E mRNA were detected in all normal ovaries and ovarian tumor samples examined by semiquantitative PCR amplification. mRNA levels of cyclin E were significantly higher in nine of 30 (30%) ovarian cancers compared with 11390254 Human
cyclin e ovarian cancers The immunohistochemical expression of cyclin E protein was confirmed in the nuclei of tumor cells in 13 of 30 (43%) ovarian cancers. p53 protein accumulation was detected in 12 of 30 (40%) ovarian cancers examined. 11390254 Human
cyclin e tumor The immunohistochemical expression of cyclin E protein was confirmed in the nuclei of tumor cells in 13 of 30 (43%) ovarian cancers. p53 protein accumulation was detected in 12 of 30 (40%) ovarian cancers examined. 11390254 Human
cyclin e ovarian cancers CONCLUSIONS: Cyclin E mRNA overexpression frequently occurs in ovarian cancers without p53 protein accumulation. 11390254 Human
cyclin e ovarian cancers Cyclin E might have an important effect on the development of a limited number of ovarian cancers. 11390254 Human
cyclin e papillomas In patient papillomas and E7 raft cultures, all p27kip1-positive cells were negative for bromodeoxyuridine (BrdU) incorporation, but only some also contained cyclin E and p21cip1. 11390614 Human
cyclin e metastases No association was observed between cyclin D1 or cyclin E, respectively, and relapse of disease or survival, while cyclin D3 over-expression was associated with development of metastases during follow-up (p = 0.005 univariate analysis, p = 0.01 multivaria 11410878 Human
cyclin e human tumor Moreover, we found that cycling human tumor cells expressing deregulated cyclin D-Cdk4/6 complexes, due to deletion of the p16(INK4a) gene, contained hypophosphorylated pRB that was bound to E2Fs in early G(1) and that E2F-responsive genes, including thos 11416152 Human
cyclin e human papilloma Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. 11420459 Human
cyclin e condylomas Limitations in specificity included minimal or no suprabasal staining for Ki-67 in immature condylomas and occasional suprabasal staining of reactive epithelial changes (10%), diffuse weak nuclear cyclin E staining in some normal or metaplastic epithelia, 11420459 Human
cyclin e malignant lymphomas Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas. 11426519 Human
cyclin e lymphomas In this review we have focused on two of the interplayers in the G1/S transition namely cyclin E and p27, and present the current knowledge of aberrations affecting these proteins in lymphomas as well as associations with clinico-pathological data includi 11426519 Human
cyclin e negative tumors Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors. 11429696 Human
cyclin e human breast cancer Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors. 11429696 Human
cyclin e tumors Low IGFBP-rP1 was associated with high cyclin E protein content, retinoblastoma protein (pRb) inactivation, low bcl-2 protein, poorly differentiated tumors and higher stage. 11429696 Human
cyclin e negative tumors Interestingly, IGFBP-rP1 showed an inverse association with proliferation (Ki-67%) in estrogen receptor negative tumors as well as in cyclin E high tumors suggesting a separate cell cycle regulatory function for IGFBP-rP1 independent of interaction with t 11429696 Human
cyclin e breast cancer Insulin/insulin-like growth factor-I and estrogen cooperate to stimulate cyclin E-Cdk2 activation and cell Cycle progression in MCF-7 breast cancer cells through differential regulation of cyclin E and p21(WAF1/Cip1). 11337496 Human
cyclin e retinoblastoma Interleukin-6 treatment resulted in rapid inhibition of cyclin-dependent kinase 2/cyclin E activity and accumulation of the hypophosphorylated retinoblastoma protein in WM35 but not in WM9 cells. 11442760 Human
cyclin e tumour Extensive evidence from mammalian cells, and in particular from tumour cells has suggested that these complexes act as master regulators of cell proliferation upstream of cyclin E. 11444049 Human
cyclin e paraffin-embedded tumor Paraffin-embedded tumor tissues were examined for protein expression of estrogen receptor (ER), PR, Ki-67, cyclin D1, TP53, HER2, beta-catenin, and cyclin E using immunohistochemical approaches. 11448907 Human
cyclin e cancer Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer. hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number of primary cancers and 14871801 Human
cyclin e primary cancers Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer. hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number of primary cancers and 14871801 Human
cyclin e tumors We have observed that functional inactivation of hCDC4 does not necessarily correlate with elevated levels of cyclin E in tumors. 14871801 Human
cyclin e primary tumors Here we show, however, that hCDC4 mutation in primary tumors correlates strongly with loss of cell cycle regulation of cyclin E. Similarly, a breast carcinoma-derived cell line mutated for hCDC4 exhibits cell cycle deregulation of cyclin E, but periodic e 14871801 Human
cyclin e breast cancer The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer. 14871808 Human
cyclin e tumors Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors that do not express estrogen receptors, HER2, p27(Kip1), or cyclin D1, but do express p53 and cyclin E. 14871808 Human
cyclin e breast cancers Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors that do not express estrogen receptors, HER2, p27(Kip1), or cyclin D1, but do express p53 and cyclin E. 14871808 Human
cyclin e breast cancer In a parsimonious multivariable proportional hazards model, protein levels of cyclin E, p27(Kip1), p53, and the presence of glomeruloid microvascular proliferation all independently predicted outcome after breast cancer. 14871808 Human
cyclin e cancers In this model, only cyclin E and p27(Kip1) levels were independent predictors in lymph node-negative cancers, whereas glomeruloid microvascular proliferation and tumor size independently predicted outcome in node-positive disease. 14871808 Human
cyclin e tumor In this model, only cyclin E and p27(Kip1) levels were independent predictors in lymph node-negative cancers, whereas glomeruloid microvascular proliferation and tumor size independently predicted outcome in node-positive disease. 14871808 Human
cyclin e rat mammary tumor Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21(Cip1). 11463487 Human
cyclin e rat mammary tumor We studied the effects of tamoxifen (TAM) on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumor and the expression of cyclin D1, cyclin E, p21(Cip1), and estrogen receptors (ER) by performing immunohistochemistry and Western blo 11463487 NA
cyclin e tumors The administration of TAM markedly decreased the tumor development and showed decreased expression of bromodeoxyuridine, cyclin D1, cyclin E, and p21(Cip1) when compared with those of the DMBA-control group; however, a few tumors showed progressive growth 11463487 Human
cyclin e tumor The administration of TAM markedly decreased the tumor development and showed decreased expression of bromodeoxyuridine, cyclin D1, cyclin E, and p21(Cip1) when compared with those of the DMBA-control group; however, a few tumors showed progressive growth 11463487 Human
cyclin e tumor This study suggests that TAM suppresses tumor development through the down-expression of cyclin D1 and cyclin E. 11463487 Human
cyclin e tumor The inhibitory effect of glycolic acid on UV-induced tumor development was accompanied by decreased expression of the following UV-induced cell-cycle regulatory proteins: proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, and the associated s 11479924 Human
cyclin e tumor The decreased expression of the cell-cycle regulatory proteins PCNA, cyclin D1, cyclin E, cdk2, and cdk4 and the signal mediators JNK, p38 kinase, and MEK may play a significant role in the inhibitory effect of glycolic acid on UV-induced skin tumor devel 11479924 Human
cyclin e breast cancer Cyclin E overexpression as an independent risk factor of visceral relapse in breast cancer. 11504517 Human
cyclin e breast cancer We investigated the implication of cyclin E overexpression for the pattern of recurrence in Korean breast cancer patients. 11504517 Human
cyclin e breast cancer METHODS: Using immunohistochemical methods, we retrospectively examined the cyclin E expression level in breast cancer specimens from 128 women who underwent curative breast surgery, and correlated the levels of expression with the pattern of relapse in p 11504517 NA
cyclin e breast carcinoma CONCLUSION: Our data suggest that cyclin E overexpression in primary breast carcinoma tissue could independently predict the risk of distant relapse, especially of visceral relapse, as the first failure after curative breast surgery. 11504517 Human
cyclin e breast cancer Previously this laboratory found that cyclin E is overexpressed and present in lower-molecular-weight (LMW) isoforms in breast cancer cells and tumor tissues compared to normal cells and tissues. 11509668 Human
cyclin e tumor Previously this laboratory found that cyclin E is overexpressed and present in lower-molecular-weight (LMW) isoforms in breast cancer cells and tumor tissues compared to normal cells and tissues. 11509668 Human
cyclin e tumor Through biochemical and mutational analyses we have identified two proteolytically sensitive sites in the amino terminus of human cyclin E that are cleaved to generate the LMW isoforms found in tumor cells. 11509668 Human
cyclin e tumor Lastly, we show that cyclin E is selectively cleaved in vitro by the elastase class of serine proteases to generate LMW forms similar to those observed in tumor cells. 11509668 Human
cyclin e tumor These studies suggest that the defective entry into and exit from S phase by tumor cells is in part due to the proteolytic processing of cyclin E, which generates hyperactive LMW isoforms whose activities have been modified from that of the full-length pr 11509668 Human
cyclin e epithelial ovarian tumors Expression of cell cycle regulators p57(KIP2), cyclin D1, and cyclin E in epithelial ovarian tumors and survival. 11521224 Human
cyclin e epithelial ovarian cancer We examined 2 groups of patients with epithelial ovarian cancer, 1 group of long-term survivors (>5 years), and 1 group of short-term survivors (<2 years) for levels of expression of the cell cycle regulators p57(KIP2), cyclin D1, and cyclin E and their r 11521224 NA
cyclin e ovarian tumor We also found a significant difference in the frequency of the cyclin E staining pattern between nonserous and serous ovarian tumor subtypes (P =.0002). 11521224 Human
cyclin e ovarian cancer Immunostaining for levels of cyclin E and p27(KIP1) expression may have potential as prognostic markers in the management of ovarian cancer. 11521224 Human
cyclin e breast carcinoma Treatment with 4D5 resulted in a dramatic accumulation of BT-474 breast carcinoma cells in G1; concomitant with reduced expression of proteins involved in sequestration of the cyclin E/Cdk2 inhibitor protein p27, increased association of p27 with Cdk2 com 11521716 Human
cyclin e hepatocellular carcinoma We also show that together with the acquired expression of TA-p73, the 'retinoblastoma pathway' is inactivated, and E2F1-target genes including cyclin E and p14(ARF) are activated in hepatocellular carcinoma. 11526499 Human
cyclin e tumours These tumours were also examined for MDM2 and P63 amplification, and for expression of p16(INK4a/CDKN2a), cyclin E, p27(Kipl)and Cox2. 11531258 Human
cyclin e lung adenocarcinoma High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients. 11557114 Human
cyclin e lung adenocarcinoma We immunohistochemically examined the expression of cyclin E and p27 in 98 cases of resected lung adenocarcinoma to evaluate the prognostic significance of cyclin E and p27. 11557114 Human
cyclin e lung adenocarcinoma Our results suggested that cyclin E over expression, in association with p27 reduction in particular, may potentially be a poor prognostic factor in lung adenocarcinoma patients. 11557114 Human
cyclin e colorectal cancer The antitumor sulfonamide E7070, causing a cellular accumulation in the G1 phase, has been shown to suppress the activation of CDK2 and cyclin E expression in HCT116 colorectal cancer cell line highly sensitive to the drug. 11562278 Human
cyclin e cancer Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. 11565033 Human
cyclin e cancers These findings implicate archipelago in developmentally regulated degradation of Cyclin E and potentially in the pathogenesis of human cancers. 11565033 Human
cyclin e breast cancer Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. 11565034 Human
cyclin e breast cancer The gene encoding hCdc4 was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E. 11565034 Human
cyclin e metastasis Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma. 11567224 Human
cyclin e colorectal carcinoma Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma. 11567224 Human
cyclin e metastasis In primary carcinomas, the reduction of cyclin E was significantly associated with large tumor size, mucinous type, venous invasion, deep infiltration, lymph nodal metastasis, peritoneal metastasis, advanced stage, and poor prognosis. 11567224 Human
cyclin e large tumor In primary carcinomas, the reduction of cyclin E was significantly associated with large tumor size, mucinous type, venous invasion, deep infiltration, lymph nodal metastasis, peritoneal metastasis, advanced stage, and poor prognosis. 11567224 Human
cyclin e primary carcinomas In primary carcinomas, the reduction of cyclin E was significantly associated with large tumor size, mucinous type, venous invasion, deep infiltration, lymph nodal metastasis, peritoneal metastasis, advanced stage, and poor prognosis. 11567224 Human
cyclin e cancer The overexpression of cyclin E and CDK2 may mainly promote the progression of early cancer. 11567224 Human
cyclin e endometrial carcinomas CONCLUSIONS: We conclude that cyclin E and cyclin B1 might be the major cell-cycle regulators involved in proliferation and reduced differentiation of endometrial carcinomas. 11570574 Human
cyclin e tumor Expression levels of the AP-1 factors were correlated with clinico-pathologic tumor parameters, steroid receptor status, Ki-67 expression and the expression levels of eight cell cycle regulatory proteins (cyclin D1, cyclin E, cyclin B1, cdk2, cdk4, p16, p 11570575 Human
cyclin e retinoblastoma MyoD activity upregulates E2F1 and enhances transcription from the cyclin E promoter in differentiating myoblasts lacking a functional retinoblastoma protein. 11570822 Human
cyclin e epithelial ovarian tumors Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors. 11585414 Human
cyclin e epithelial ovarian carcinoma OBJECTIVE: The aim of this study was to further evaluate whether the expression of p27(kip1), cyclin E, and cdk2 is related to the malignancy of ovarian tumors and whether their expressions, alone or in combination, are associated with prognosis in epithe 11585414 Human
cyclin e malignant tumors The expression of cyclin E and cdk2 gradually increased from benign to borderline to malignant tumors. 11585414 Human
cyclin e ovarian tumors CONCLUSIONS: Our results suggest that loss of p27(kip1) expression and overexpression of cyclin E or cdk2 were significantly associated with malignancy in ovarian tumors. p27(kip1) and cyclin E proteins may be valuable prognostic factors for epithelial ov 11585414 Human
cyclin e epithelial ovarian carcinoma CONCLUSIONS: Our results suggest that loss of p27(kip1) expression and overexpression of cyclin E or cdk2 were significantly associated with malignancy in ovarian tumors. p27(kip1) and cyclin E proteins may be valuable prognostic factors for epithelial ov 11585414 Human
cyclin e breast cancer We conclude that the ability of insulin to increase the cellular amounts of geranylgeranylated Rho-A results in potentiation of the LPA effect on cyclin E expression and degradation of p27Kip1 and cell cycle progression in MCF-7 breast cancer cells. 11500498 Human
cyclin e neoplasm Fixed, paraffin-embedded tissue sections of each neoplasm were also assessed using immunohistochemical methods with a panel of antibodies specific for p53, retinoblastoma protein, p16, cyclin D1, and cyclin E, and the results were correlated with clinical 11598855 Human
cyclin e retinoblastoma Fixed, paraffin-embedded tissue sections of each neoplasm were also assessed using immunohistochemical methods with a panel of antibodies specific for p53, retinoblastoma protein, p16, cyclin D1, and cyclin E, and the results were correlated with clinical 11598855 Human
cyclin e hydatidiform moles In this study we investigated the immunostaining patterns of G(1) restriction point and G(1)-S regulatory proteins E2F-1, Cdk2, cyclin E, p27(kip1), and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial mo 11598175 Human
cyclin e partial moles In this study we investigated the immunostaining patterns of G(1) restriction point and G(1)-S regulatory proteins E2F-1, Cdk2, cyclin E, p27(kip1), and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial mo 11598175 Human
cyclin e complete moles In this study we investigated the immunostaining patterns of G(1) restriction point and G(1)-S regulatory proteins E2F-1, Cdk2, cyclin E, p27(kip1), and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial mo 11598175 Human
cyclin e complete moles Cyclin E was maximally expressed by complete moles and choriocarcinomas, and showed an inverse relationship with the cyclin-dependent kinase inhibitor p27(kip1). 11598175 Human
cyclin e complete moles The different expression patterns of cyclin E and E2F-1 in partial and complete moles may be useful in distinguishing these two entities. 11598175 Human
cyclin e melanomas Cyclin E, p21(Waf-1) and p27(Kip-1) are also elevated in many primary melanomas, whereas p16(INK4a) is mutated or deleted in many invasive and metastatic melanomas. 11602203 Human
cyclin e metastatic melanomas Cyclin E, p21(Waf-1) and p27(Kip-1) are also elevated in many primary melanomas, whereas p16(INK4a) is mutated or deleted in many invasive and metastatic melanomas. 11602203 Human
cyclin e cancers Although cyclin E gene amplification is reported to be an important event in various cancers, it is rarely found in human colorectal cancers. 11680595 Human
cyclin e human colorectal cancers Although cyclin E gene amplification is reported to be an important event in various cancers, it is rarely found in human colorectal cancers. 11680595 Human
cyclin e colorectal cancer As one of the candidate factors of other mechanisms relating to cyclin E, we analyzed cyclin E-dependent kinase activity in colorectal cancer. 11680595 Human
cyclin e colorectal cancers Protein levels of cyclin E, its catalytic subunit, cyclin-dependent kinase 2 (Cdk2), and p21 and p27 were determined by western blot or immunohistochemistry in 27 colorectal cancers and 10 colorectal adenomas, and compared with adjacent normal colonic muc 11680595 Human
cyclin e colorectal adenomas Protein levels of cyclin E, its catalytic subunit, cyclin-dependent kinase 2 (Cdk2), and p21 and p27 were determined by western blot or immunohistochemistry in 27 colorectal cancers and 10 colorectal adenomas, and compared with adjacent normal colonic muc 11680595 Human
cyclin e colorectal cancer We clearly showed that although the protein level of cyclin E in colorectal cancer and adenoma was similar to that of adjacent normal mucosa, cylin E-dependent kinase activity was increased in all the cases of colorectal cancers and 90% of colorectal aden 11680595 Human
cyclin e colorectal cancers We clearly showed that although the protein level of cyclin E in colorectal cancer and adenoma was similar to that of adjacent normal mucosa, cylin E-dependent kinase activity was increased in all the cases of colorectal cancers and 90% of colorectal aden 11680595 Human
cyclin e colorectal adenomas We clearly showed that although the protein level of cyclin E in colorectal cancer and adenoma was similar to that of adjacent normal mucosa, cylin E-dependent kinase activity was increased in all the cases of colorectal cancers and 90% of colorectal aden 11680595 Human
cyclin e adenoma We clearly showed that although the protein level of cyclin E in colorectal cancer and adenoma was similar to that of adjacent normal mucosa, cylin E-dependent kinase activity was increased in all the cases of colorectal cancers and 90% of colorectal aden 11680595 Human
cyclin e colorectal cancer The results of this study strongly suggest that activation of cyclin E-dependent kinase activity may play an important role in colorectal cancer, and its level appears to be related to increased Cdk2 and decreased p21 and p27 amounts rather than cyclin E 11680595 Human
cyclin e tumor Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis. 11723246 Human
cyclin e leukaemia Nitric oxide induces apoptosis in NALM-6, a leukaemia cell line with low cyclin E protein levels. 11737001 Human
cyclin e t-47d human breast cancer To determine the role of decreased cyclin expression, T-47D human breast cancer cells constitutively expressing cyclin D1 or cyclin E were treated with the progestin ORG 2058. 11590147 Human
cyclin e non-hodgkins lymphoma Immunoreactivity for p27(KIP1) and cyclin E is an independent predictor of survival in primary gastric non-Hodgkin's lymphoma. 11745451 Human
cyclin e gastric lymphoma Our aim was to assess the prognostic implications of the expression of p27(KIP1) and cyclin E in gastric lymphoma. 11745451 Human
cyclin e large-cell lymphomas The prognostic role of p27/cyclin E expression was confirmed when analyzed separately within LGMLs and large-cell lymphomas. 11745451 Human
cyclin e tumor Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression. 14645251 Human
cyclin e retinoblastoma Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression. 14645251 Human
cyclin e tumors TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins. 11838966 Human
cyclin e invasive carcinoma METHODS AND RESULTS: Immunostaining for cyclin D1, cyclin E, p21, p27, p53 and Ki67 proteins was performed using 22 normal mucosa, 17 reactive change, 22 low-grade dysplasia, 15 high-grade dysplasia and 22 mucosal invasive carcinoma specimens. 11903577 Human
cyclin e invasive carcinoma Furthermore, expression of cyclin D1, cyclin E, p27 and p53 in mucosal invasive carcinoma were significantly different from those in high-grade dysplasia (P=0.0079, P=0.0237, P=0.0042 and P= 0.0299, respectively). 11903577 Human
cyclin e invasive carcinoma Cyclin D1, cyclin E, p27 and p53 help to distinguish high-grade dysplasia from mucosal invasive carcinoma. 11903577 Human
cyclin e papillomatosis Compared with normal bladder epithelium, in papillomatosis at week 4, the BrdU index and immunohistochemical positivities for cyclin D1 and cyclin E were significantly elevated, whereas values for p27(Kip1) tended to be reduced. 10607743 Human
cyclin e transitional cell carcinomas Two weeks after uracil withdrawal, transitional cell carcinomas, with a low p27(Kip1) and high cyclin D1 and cyclin E staining pattern, could be easily distinguished from surrounding regressing epithelium. 10607743 Human
cyclin e papillomatosis These data indicate that during regression of papillomatosis after cessation of a proliferative stimulus, expression of p27(Kip1)is elevated, accompanied by a lowering of cyclin D1 and cyclin E. 10607743 Human
cyclin e adrenocortical tumors High expression of cyclin E and G1 CDK and loss of function of p57KIP2 are involved in proliferation of malignant sporadic adrenocortical tumors. 10634406 Human
cyclin e malignant tumors By contrast, abrogation of the p57KIP2 gene expression and increased expression of G1 cyclins (cyclin E) and G1 CDKs (CDK2 and CDK4) were associated with high activity of G1 cyclin-CDK complexes in malignant tumors and in the H295R cell line. 10634406 Human
cyclin e non-small cell lung cancers Cyclin E expression, a potential prognostic marker for non-small cell lung cancers. 10656426 Human
cyclin e tumors Cyclin E is a G1 cyclin that has been shown to be one of the key regulators of the G1-S transition and could consequently be a deregulated molecule in tumors. 10656426 Human
cyclin e tumors In the present study, we have characterized cyclin E expression by immunohistochemistry in 217 resected non-small cell lung cancers (NSCLCs) and found large variations in cyclin E expression among tumors. 10656426 Human
cyclin e non-small cell lung cancers In the present study, we have characterized cyclin E expression by immunohistochemistry in 217 resected non-small cell lung cancers (NSCLCs) and found large variations in cyclin E expression among tumors. 10656426 Human
cyclin e tumors High-level cyclin E expression (a cyclin E-labeling index > or =30%), observed in 115 (53%) of 217 NSCLCs, was more frequently found in tumors from smokers than from nonsmokers (P = 0.001), in squamous cell carcinomas than in nonsquamous cell carcinomas ( 10656426 Human
cyclin e squamous-cell carcinomas High-level cyclin E expression (a cyclin E-labeling index > or =30%), observed in 115 (53%) of 217 NSCLCs, was more frequently found in tumors from smokers than from nonsmokers (P = 0.001), in squamous cell carcinomas than in nonsquamous cell carcinomas ( 10656426 Human
cyclin e squamous-cell carcinomas Multivariate logistic regression analysis for the correlation between cyclin E expression and various characteristics showed a significant association of high-level cyclin E expression with squamous cell carcinomas (P = 0.005). 10656426 Human
cyclin e tumors Patients with tumors having high-level cyclin E expression survived a significantly shorter time than patients with tumors having low-level expression, both among the 151 patients with potentially curatively resected NSCLCs (5-year survival rates, 48 and 10656426 Human
cyclin e embryonal carcinomas CIS lesions showed abundant p18, low cyclin E, and moderate p27, in contrast with most invasive seminomas and embryonal carcinomas with very low-to-negative p18, often elevated cyclin E, and, unexpectedly, sustained or increased p27. 10652429 Human
cyclin e germ cell tumours Our results suggest increased abundance of cyclin E, and particularly downmodulation or loss of p18INK4C as the features that correlate with progression from CIS to invasive germ cell tumours of the human testis. 10652429 Human
cyclin e non-small cell lung cancer Prognostic significance of cyclin E overexpression in resected non-small cell lung cancer. 10667567 Human
cyclin e non-small cell lung cancer However, the clinical significance of cyclin E expression in patients with non-small cell lung cancer remains unknown. 10667567 Human
cyclin e non-small cell lung cancer We examined the expression of cyclin E in 242 resected non-small cell lung cancer in pathological stages I-IIIa and analyzed its relation to clinicopathological factors. 10667567 NA
cyclin e tumors We concluded that cyclin E overexpression relates to deeply invasive tumors and is correlated with poor prognosis. 10667567 Human
cyclin e tumor Processing of cyclin E differs between normal and tumor breast cells. 10667604 Human
cyclin e tumor In tumor cells and tissues, cyclin E is overexpressed and present in its lower molecular weight (LMW) isoforms, and it can be used as a prognosticator for poor patient outcome. 10667604 Human
cyclin e breast cancer In this study, we have examined differences in the processing of cyclin E between normal mammary epithelial and breast cancer cell lines. 10667604 Human
cyclin e tumor Five NH2-terminally deleted epitope-tagged (FLAG) cyclin E vectors were constructed spanning the range of LMW forms observed in tumor cells. 10667604 Human
cyclin e tumor These constructs were transfected into normal and tumor cells and analyzed for the production of cyclin E-FLAG protein products by Western blot analysis with FLAG and cyclin E antibodies. 10667604 Human
cyclin e tumor Tumor and normal cells always process the cyclin E-FLAG protein in the same way as endogenously expressed cyclin E. 10667604 Human
cyclin e tumor These studies suggest that the LMW forms of cyclin E detected at a much higher level in tumor cells arise from posttranslational action of a protease. 10667604 Human
cyclin e gastric cancer Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. 10666388 Human
ccne gastric cancer We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse transcriptase-polymerase chain reaction Southern blots, and imm 10666388 Human
cyclin e gastric cancer We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse transcriptase-polymerase chain reaction Southern blots, and imm 10666388 Human
ccne tumor We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse transcriptase-polymerase chain reaction Southern blots, and imm 10666388 Human
cyclin e tumor We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse transcriptase-polymerase chain reaction Southern blots, and imm 10666388 Human
ccne gastric cancer Immunohistochemistry demonstrated 21. 5%, 34.2%, 30.4%, 44.2%, and 48.0% positivity for CCND1, CCND2, CCNE, CDK2, and CDK4, respectively, in the 260 gastric cancer cases. 10666388 Human
ccne tumor The results indicate that CCND2 cytoplasmic localization might reflect an important physiological role in tumor progression, whereas CCNE overexpression correlates with differentiation and a good prognosis, possibly because of accumulation of inactive for 10666388 Human
cyclin e invasive adenocarcinoma There was significantly greater cyclin E expression in TEM/endometriosis than in normal cervix (P = 0.03) with a nonsignificant further increase in CGIN and invasive adenocarcinoma. 14766257 Human
cyclin e prostate cancer The inhibition of cyclin E/cdk2 by p27Kip1 contributes to G1 arrest of LNCaP following high dose DHT. p27KiP1 may be a key effector of androgen dependent growth modulation in prostate cancer cells. 10698512 Human
cyclin e bladder tumor In addition, we found down-regulation of cyclin B, cyclin E, and dephosphorylation of cdk2 in ciprofloxacin-treated bladder tumor cells. 10741713 Human
cyclin e transitional cell carcinoma Cyclin E overexpression in transitional cell carcinoma of the bladder. 10738114 Human
cyclin e transitional-cell bladder carcinoma We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. 10738114 Human
cyclin e transitional-cell bladder carcinoma These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma. 10738114 Human
cyclin e tumor These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma. 10738114 Human
cyclin e carcinomas The expression of cyclin E was more frequently present in carcinomas than in adenomas. 10746668 Human
cyclin e adenomas The expression of cyclin E was more frequently present in carcinomas than in adenomas. 10746668 Human
cyclin e adenomas However, no high expression of cyclin E was observed among the adenomas. 10746668 Human
cyclin e carcinoma By a semiquantitative evaluation comparing adenoma and carcinoma in the same stomach, the increased degrees of both p21/waf1 and cyclin E were highlighted. 10746668 Human
cyclin e adenoma By a semiquantitative evaluation comparing adenoma and carcinoma in the same stomach, the increased degrees of both p21/waf1 and cyclin E were highlighted. 10746668 Human
cyclin e gastric adenomas In conclusion, the expressions of p53, p21/waf1, p27/kip1, and cyclin E were considered to be of great value for estimating the dysplastic progression of gastric adenomas. 10746668 Human
cyclin e tumors Cyclin E overexpression and p53 mutations occur frequently in tumors. 10763820 Human
cyclin e tumors Here, we show that cyclin E overexpression and loss of p53 synergistically increase the frequency of centrosome hyperamplification in cultured cells as well as in tumors developed in p53-null, heterozygous, and wildtype mice. 10763820 Human
cyclin e gastric cancer The cyclin E gene is amplified in 15%-20% of gastric cancer. 10779229 Human
cyclin e cervical carcinoma Expression of cyclin E and p27(KIP1) in cervical carcinoma. 10779628 Human
cyclin e invasive cervical carcinoma (icc) Using formalin-fixed, paraffin-embedded cervical tissues, we investigated the expression of cyclin E and p27(KIP1) by immunohistochemistry, and human papillomavirus (HPV) types 16 and 18 by nested polymerase chain reaction (PCR) in 22 control cases, 23 ca 10779628 Human
cyclin e cervical intraepithelial neoplasia (cin) Using formalin-fixed, paraffin-embedded cervical tissues, we investigated the expression of cyclin E and p27(KIP1) by immunohistochemistry, and human papillomavirus (HPV) types 16 and 18 by nested polymerase chain reaction (PCR) in 22 control cases, 23 ca 10779628 Human
cyclin e invasive cancer Patients with either invasive cancer or CIN were found to have a significantly higher cyclin E index (CEI) than the controls (P<0.05). 10779628 Human
cyclin e cervical carcinoma Our results were consistent with the concept that the deregulated expression of cyclin E and p27(KIP1) may play an important role in the neoplastic transformation of cervical carcinoma. 10779628 Human
cyclin e tumor Expression of cyclin D1 and cyclin E rather decreased with the tumor progression. 10779641 Human
cyclin e metastasis In conclusion, losses of p16 and p27 seem to play a significant role during the gastric carcinogenesis, and the G1 checkpoint cell cycle proteins such as pRb, cdk4, cyclin D1, and cyclin E variably participate in the gastric carcinogenesis and metastasis 10779641 Human
cyclin e squamous cervical carcinoma (scc) OBJECTIVES: To examine the prognostic significance of the protein expression of cyclin E, cyclin A and cyclin D3, and of the proliferation markers Ki-67 and BM28 in early squamous cervical carcinoma (SCC). 14751136 Human
cyclin e tumors RESULTS: Cyclin E, cyclin A, Ki-67 and BM28 expression was increased in SCC and high expression was observed in 81.5% (180/221), 35% (78/221), 25.5% (56/221) and 92% (204/221) of tumors, respectively. 14751136 Human
cyclin e papillary thyroid carcinoma Cyclin E expression in papillary thyroid carcinoma: relation to staging. 14735474 Human
cyclin e papillary thyroid carcinoma (ptc) However, the clinical significance of cyclin E expression in patients with papillary thyroid carcinoma (PTC) remains unknown. 14735474 Human
cyclin e lymph-node metastases All the lymph node metastases coexisted with cyclin E expression and most, but not all, of them coexisted with cyclin E overexpression. 14735474 Human
cyclin e hepatocellular carcinoma Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma. 10847487 Human
cyclin e adult hepatocellular carcinoma Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma. 10847487 Human
cyclin e lymphoma We found a substantial increase in cyclin E mRNA, accompanied by increased production of cyclin E protein and cyclin E/Cdk2 kinase activity in multiple myeloma and lymphoma cells following irradiation. 10851086 Human
cyclin e multiple myeloma We found a substantial increase in cyclin E mRNA, accompanied by increased production of cyclin E protein and cyclin E/Cdk2 kinase activity in multiple myeloma and lymphoma cells following irradiation. 10851086 Human
cyclin e leiomyosarcoma Cyclin E was expressed exclusively in leiomyosarcoma. 10854234 Human
cyclin e leiomyoma These results suggest 1) up-regulation of active cyclin A/cdk2 expression and associated kinase activity is critical for unrestrained cell proliferation; 2) cyclin E/cdk2 complexes may play a crucial role in leiomyosarcoma; 3) immunohistochemical detectio 10854234 Human
cyclin e leiomyosarcoma These results suggest 1) up-regulation of active cyclin A/cdk2 expression and associated kinase activity is critical for unrestrained cell proliferation; 2) cyclin E/cdk2 complexes may play a crucial role in leiomyosarcoma; 3) immunohistochemical detectio 10854234 Human
cyclin e tumours Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHODS: We therefore investigated the expressio 10870044 Human
cyclin e endocrine neoplasia Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHODS: We therefore investigated the expressio 10870044 Human
cyclin e pituitary adenomas Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHODS: We therefore investigated the expressio 10870044 Human
cyclin e tumours All tumours and normal tissue were immunostained for cyclin D1 and cyclin E using a standard technique, and were then subjected to blinded analysis by a single observer and the extent of staining quantified on the basis of 500 cell counts per tissue. 10870044 Human
cyclin e tumours Cyclin E was also sparsely expressed, but was specifically increased in corticotroph tumours from patients with Cushing's disease. 10870044 Human
cyclin e tumours CONCLUSIONS: We report cyclin D1 over-expression in aggressive and non-functioning pituitary tumours, and that cyclin E expression is more frequently seen in Cushing's disease. 10870044 Human
cyclin e tumours The high level of cyclin E expression in Cushing's disease may relate to the low level of p27 protein expression previously reported in corticotroph tumours. 10870044 Human
cyclin e pulmonary metastasis Evaluation of cyclin expression in testicular germ cell tumors: cyclin E correlates with tumor type, advanced clinical stage, and pulmonary metastasis. 10874672 Human
cyclin e testicular germ-cell tumors Evaluation of cyclin expression in testicular germ cell tumors: cyclin E correlates with tumor type, advanced clinical stage, and pulmonary metastasis. 10874672 Human
cyclin e tumor Evaluation of cyclin expression in testicular germ cell tumors: cyclin E correlates with tumor type, advanced clinical stage, and pulmonary metastasis. 10874672 Human
cyclin e mixed germ cell tumors We compared the immunoreactivity of 20 pure seminomas with 20 mixed germ cell tumors composed predominantly of embryonal carcinoma with a variety of proliferation markers, including Ki-67, cyclin A, and cyclin E. 10874672 Human
cyclin e embryonal carcinoma We compared the immunoreactivity of 20 pure seminomas with 20 mixed germ cell tumors composed predominantly of embryonal carcinoma with a variety of proliferation markers, including Ki-67, cyclin A, and cyclin E. 10874672 Human
cyclin e tumors All 40 tumors stained for Ki-67, and 19 of 20 (95%) seminomas and 18 of 20 (90%) embryonal carcinomas stained positively for cyclin A. Cyclin E stained 14 of 19 (74%) of the embryonal carcinomas and only 4 of 20 (20%) of the seminomas (Fisher's exact 10874672 Human
cyclin e embryonal carcinomas All 40 tumors stained for Ki-67, and 19 of 20 (95%) seminomas and 18 of 20 (90%) embryonal carcinomas stained positively for cyclin A. Cyclin E stained 14 of 19 (74%) of the embryonal carcinomas and only 4 of 20 (20%) of the seminomas (Fisher's exact 10874672 Human
cyclin e embryonal carcinomas For both seminomas and embryonal carcinomas, staining with cyclin E did not correlate with the presence of lymphovascular invasion or capsular invasion. 10874672 Human
cyclin e tumors In addition, pulmonary spread in embryonal carcinomas (four patients) and seminomas (one patient) occurred only in patients whose tumors were cyclin E positive (P = .014). 10874672 Human
cyclin e embryonal carcinomas In addition, pulmonary spread in embryonal carcinomas (four patients) and seminomas (one patient) occurred only in patients whose tumors were cyclin E positive (P = .014). 10874672 Human
cyclin e testicular germ-cell tumors Although Ki-67 and cyclin A offer little prognostic information in testicular germ cell tumors, cyclin E immunoreactivity correlates with tumor type and is strongly predictive of distant tumor spread. 10874672 Human
cyclin e tumor Although Ki-67 and cyclin A offer little prognostic information in testicular germ cell tumors, cyclin E immunoreactivity correlates with tumor type and is strongly predictive of distant tumor spread. 10874672 Human
cyclin e breast cancers Cyclin D1 and E are frequently overexpressed in breast cancers, and cyclin E overexpression has been correlated with a poor prognostic outcome. 10917130 Human
cyclin e cancer Reduction in levels of p27(Kip1) and increased expression of cyclin E also occur and carry a poor prognostic significance in many common forms of cancer. 10919634 Human
cyclin e breast cancer Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family members. 10918184 Human
cyclin e breast cancer Therefore, we studied protein expression of 6 cell cycle-regulatory proteins (Rb, p16, p21, p27, cyclin D1, and cyclin E) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP-1 fami 10918184 Human
cyclin e tumour Concerning other cell cycle associated proteins, p27 expression was inversely correlated with p21 expression, however, there was no correlation either with cyclin D1 and cyclin E or with expression of p53, bcl-2 and tumour cell proliferation. 10928108 Human
cyclin e partial moles RESULTS: The cyclin E indexes (CEI) were as follows: 25.7% +/- 6.2% for hydropic change, 35.3% +/- 12.7% for triploid partial moles, 42.2% +/- 13.1% for diploid/tetraploid complete moles, and 63.6% +/- 9.5% for choriocarcinomas. 10931468 Human
cyclin e complete moles RESULTS: The cyclin E indexes (CEI) were as follows: 25.7% +/- 6.2% for hydropic change, 35.3% +/- 12.7% for triploid partial moles, 42.2% +/- 13.1% for diploid/tetraploid complete moles, and 63.6% +/- 9.5% for choriocarcinomas. 10931468 Human
cyclin e melanoma Exponentially growing melanoma cell lines were exposed in vitro to DHA and then assessed for (a) inhibition of cell growth; (b) expression of cyclins and cyclin-dependent kinase inhibitors in individual cells by flow cytometry and immunocytochemistry usin 10945621 Human
cyclin e atypical adenomatous hyperplasia To clarify the significance of p27 aberrations in the tumourigenesis of lung adenocarcinoma, p27 expression was investigated by immunohistochemistry in lung adenocarcinoma and its precursor lesion, atypical adenomatous hyperplasia (AAH), and correlated wi 10951396 Human
cyclin e lung adenocarcinoma To clarify the significance of p27 aberrations in the tumourigenesis of lung adenocarcinoma, p27 expression was investigated by immunohistochemistry in lung adenocarcinoma and its precursor lesion, atypical adenomatous hyperplasia (AAH), and correlated wi 10951396 Human
cyclin e cancer We report that cyclin E, an oncogene that is deregulated in breast and other human cancers, can sensitize cancer cells to cisplatin/taxol combinations. 10953323 Human
cyclin e cancers We report that cyclin E, an oncogene that is deregulated in breast and other human cancers, can sensitize cancer cells to cisplatin/taxol combinations. 10953323 Human
cyclin e tumors These results suggest that cyclin E functions as a coactivator of the AR, and that aberrant expression of cyclin E in tumors may contribute to persistent activation of AR function, even during androgen ablation therapy. 10953010 Human
cyclin e urinary bladder cancer High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. 10980118 Human
ccne bladder cancer To investigate the role of cyclin E alterations in bladder cancer, a tissue microarray of 2,317 specimens from 1,842 bladder cancer patients was constructed and analyzed for CCNE amplification by fluorescence in situ hybridization and for cyclin-E protein 10980118 Human
cyclin e bladder cancer To investigate the role of cyclin E alterations in bladder cancer, a tissue microarray of 2,317 specimens from 1,842 bladder cancer patients was constructed and analyzed for CCNE amplification by fluorescence in situ hybridization and for cyclin-E protein 10980118 Human
cyclin-e bladder cancer To investigate the role of cyclin E alterations in bladder cancer, a tissue microarray of 2,317 specimens from 1,842 bladder cancer patients was constructed and analyzed for CCNE amplification by fluorescence in situ hybridization and for cyclin-E protein 10980118 Human
cyclin e tumors Immunohistochemically detectable cyclin E expression was strong in 233 (12.4%), weak in 354 (18.9%), and negative in 1, 286 of the 1,873 interpretable tumors. 10980118 Human
cyclin e bladder carcinomas It is concluded that cyclin E overexpression is characteristic to a subset of bladder carcinomas, especially at the stage of early invasion. 10980118 Human
ccne cancer This analysis of the prognostic impact of CCNE gene amplification and protein expression in >1,500 arrayed bladder cancers was accomplished in a period of 2 weeks, illustrating how the tissue microarray technology remarkably facilitates the evaluation of 10980118 Human
ccne bladder cancers This analysis of the prognostic impact of CCNE gene amplification and protein expression in >1,500 arrayed bladder cancers was accomplished in a period of 2 weeks, illustrating how the tissue microarray technology remarkably facilitates the evaluation of 10980118 Human
cyclin e advanced gastric carcinoma The cooperative role of p27 with cyclin E in the prognosis of advanced gastric carcinoma. 11002215 Human
cyclin e gastric carcinoma This study investigated the protein expression of p27 with cyclin E in the progression and prognosis of gastric carcinoma. 11002215 Human
cyclin e tumors Both p27 and cyclin E expression were related to histology of tumors but not to depth of invasion, lymph node metastasis, or stage grouping. 11002215 Human
cyclin e lymph-node metastasis Both p27 and cyclin E expression were related to histology of tumors but not to depth of invasion, lymph node metastasis, or stage grouping. 11002215 Human
cyclin e tumors Tumors were divided into two groups according to the expression of cyclin E. 11002215 Human
cyclin e tumors Within the cyclin E positive tumors, the five-year survival rate was higher in patients with a p27 positive tumor than in those with a p27 negative tumor (P < 0.05). 11002215 Human
cyclin e negative tumor Within the cyclin E positive tumors, the five-year survival rate was higher in patients with a p27 positive tumor than in those with a p27 negative tumor (P < 0.05). 11002215 Human
cyclin e tumor Within the cyclin E positive tumors, the five-year survival rate was higher in patients with a p27 positive tumor than in those with a p27 negative tumor (P < 0.05). 11002215 Human
cyclin e tumors Patients with cyclin E positive tumors showing low expression of p27 had a poor prognosis. 11002215 Human
cyclin e tumors In cyclin E negative group tumors, no significant differences were observed irrespective of p27 expression. 11002215 Human
cyclin e tumors CONCLUSIONS: Reduced p27 expression is a negative prognostic factor for patients with cyclin E positive tumors. 11002215 Human
cyclin e human colon cancer To more clearly define the temporal events leading to the G1/S transition, sequential changes in the expression of cyclin E and cdks 2, 4, and 6, as well as the phosphorylation of the retinoblastoma protein (pRb), were assayed in RA28 cells, a variant of 11032757 Human
cyclin e retinoblastoma To more clearly define the temporal events leading to the G1/S transition, sequential changes in the expression of cyclin E and cdks 2, 4, and 6, as well as the phosphorylation of the retinoblastoma protein (pRb), were assayed in RA28 cells, a variant of 11032757 Human
cyclin e human colon cancer Induction of a CD1 antisense gene in a human colon cancer cell line resulted in rapid, concomitant changes in CD1 mRNA and protein, cyclin E, cdk2, cdk4, and cdk6, as well as the ratio of ppRb to pRb. 11032757 Human
cyclin e melanoma The down-regulation of PTN in transduced melanoma cells coincided with the down-regulation of the cell-cycle regulator cyclin E and the up-regulation of the cell-cycle inhibitor p21WAF1/Cip1. 11041363 Human
cyclin e gastric carcinoma Expression of cell-cycle regulators p27 and cyclin E correlates with survival in gastric carcinoma patients. 11038303 Human
cyclin e gastric cancer The aim of the study was to examine the expression of p27 and cyclin E in gastric cancer and to evaluate their prognostic implication. 11038303 Human
cyclin e tumors Tumors with low p27 and high cyclin E expression were associated with the highest mortality expression (RR, 9.8; CI = 1.2-80; P = 0.03). 11038303 Human
cyclin e mcf7 breast cancer Cyclin E overexpression enhances cytokine-mediated apoptosis in MCF7 breast cancer cells. 12847548 Human
cyclin e human tumors Cyclin E, the regulatory component of the cyclin E/cyclin-dependent kinase (CDK) complex, is required for proliferation and overexpression of this cyclin is associated with many types of human tumors. 12847548 Human
cyclin e breast cancer To elucidate the mechanism by which cyclin E overexpression promotes tumorigenesis, cyclin E was overexpressed in two breast cancer lines: MCF7 and T47D. 12847548 Human
cyclin e small-cell lung carcinoma Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcin 11052627 Human
cyclin e non-small cell lung carcinoma Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcin 11052627 Human
cyclin e breast carcinoma Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcin 11052627 Human
cyclin e colon carcinoma Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcin 11052627 Human
cyclin e prostate carcinoma Expression of pRb, cyclin D1, cdk4, cyclin E, cdk2, E2F1 and DP-1 was determined in MCF-7 and MDA-MB-468 breast carcinoma cells, H460 and Calu-6 non-small cell lung carcinoma cells, H82 and SW2 small cell lung carcinoma cells, HCT116 and HT29 colon carcin 11052627 Human
cyclin e tumors Expression of cyclin E was very low in MCF-7 and HT29 and high in H460 in culture and was very low in MCF-7, H460, Calu-6, H82, HT29 and DU-145 in tumors and high in HCT116 and LNCaP. 11052627 Human
cyclin e primary gastric cancer In order to study the cell cycle regulatory mechanisms in gastric cancer, we have analyzed the protein expression of cyclin D1 and cyclin E in 76 tumor specimens from patients with primary gastric cancer, using immunohistochemistry. 11059220 Human
cyclin e gastric cancer In order to study the cell cycle regulatory mechanisms in gastric cancer, we have analyzed the protein expression of cyclin D1 and cyclin E in 76 tumor specimens from patients with primary gastric cancer, using immunohistochemistry. 11059220 Human
cyclin e tumor In order to study the cell cycle regulatory mechanisms in gastric cancer, we have analyzed the protein expression of cyclin D1 and cyclin E in 76 tumor specimens from patients with primary gastric cancer, using immunohistochemistry. 11059220 Human
cyclin e lymph-node metastasis Cyclin E overexpression was correlated with a high incidence of lymph node metastasis, a low incidence of T1, and with Stage I. 11059220 Human
cyclin e gastric carcinoma These results suggested that in gastric carcinoma, cyclin E overexpression was useful as a prognostic indicator, but cyclin D1 was not. 11059220 Human
cyclin e breast cancer Cyclin E, a G(1) cyclin, is overexpressed and present in low molecular weight (LMW) isoforms in breast cancer cells and tumor tissues. 11095697 Human
cyclin e tumor Cyclin E, a G(1) cyclin, is overexpressed and present in low molecular weight (LMW) isoforms in breast cancer cells and tumor tissues. 11095697 Human
cyclin e tumor We show that a new splice variant of cyclin E found in tumor cells isolated by the Splice Capture strategy, named Delta48, activates CDK2 more robustly than full-length cyclin E when assayed from transiently transfected cells with the natural substrate GS 11095697 Human
cyclin e tumor We also found the Splice Capture method to be superior to the conventional RNase protection assay in analyzing the cyclin E mRNA present in normal and tumor cells. 11095697 Human
cyclin e tumor Splice Capture enumerated the relative abundance of known forms of cyclin E mRNA and easily discovered new splice variants in both normal and tumor cells. 11095697 Human
cyclin e laryngeal squamous-cell carcinomas Prognostic significance of cyclin E overexpression in laryngeal squamous cell carcinomas. 11106240 Human
cyclin e laryngeal squamous cell carcinoma (lscc) However, the clinical significance of cyclin E in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. 11106240 Human
cyclin e lymph-node metastasis Cyclin E overexpression was observed in 54 cases (52.94%) of LSCC and was significantly correlated with the tumor site (P = 0.012), tumor size (P = 0.006), poor differentiation (P = 0.026), lymph node metastasis (P = 0.012), and advanced stage (P = 0.002) 11106240 Human
cyclin e tumor Cyclin E overexpression was observed in 54 cases (52.94%) of LSCC and was significantly correlated with the tumor site (P = 0.012), tumor size (P = 0.006), poor differentiation (P = 0.026), lymph node metastasis (P = 0.012), and advanced stage (P = 0.002) 11106240 Human
cyclin e tumor A positive correlation between the cyclin E expression and proliferative activity of tumor cells was found (r = 0.896; P < 0.0001). 11106240 Human
cyclin e lymph-node metastasis By multivariate analysis, lymph node metastasis and cyclin E overexpression were independent prognostic factors for disease-free survival, and tumor size, lymph node metastasis, advanced stage, as well as cyclin E overexpression were independent prognosti 11106240 Human
cyclin e tumor By multivariate analysis, lymph node metastasis and cyclin E overexpression were independent prognostic factors for disease-free survival, and tumor size, lymph node metastasis, advanced stage, as well as cyclin E overexpression were independent prognosti 11106240 Human
cyclin e adenocarcinoma MKN-7 well-differentiated adenocarcinoma cell line has amplification of c-erbB2 oncogene and cyclin E gene. 11107048 Human
cyclin e renal tumors Of particular interest is the presence of a predominant 35 kDa cyclin E protein variant form in primary renal tumors. 11133805 Human
cyclin e esophageal adenocarcinomas Identification and characterization of a 19q12 amplicon in esophageal adenocarcinomas reveals cyclin E as the best candidate gene for this amplicon. 11156406 Human
cyclin e tumors Among these seven ESTs, cyclin E showed the highest frequency of gene amplification and overexpression in the tumors examined, which allowed us to finalize the core-amplified region to <300 kb. 11156406 Human
cyclin e tumors The fact that cyclin E overexpression was found only in the amplified tumors examined indicates that gene amplification underlies the cyclin E gene overexpression. 11156406 Human
cyclin e tumors We induced rat mammary tumors in 7-week-old female Sprague-Dawley rats by intragastric administration of 7,12-dimethylbenz(a)anthracene (DMBA), and analyzed by immunohistochemistry the expression of cyclin D1, cyclin E, p21(Cip1), and p27(Kip1) in carcino 11123420 Human
cyclin e rat mammary tumors We induced rat mammary tumors in 7-week-old female Sprague-Dawley rats by intragastric administration of 7,12-dimethylbenz(a)anthracene (DMBA), and analyzed by immunohistochemistry the expression of cyclin D1, cyclin E, p21(Cip1), and p27(Kip1) in carcino 11123420 Human
cyclin e carcinomas We induced rat mammary tumors in 7-week-old female Sprague-Dawley rats by intragastric administration of 7,12-dimethylbenz(a)anthracene (DMBA), and analyzed by immunohistochemistry the expression of cyclin D1, cyclin E, p21(Cip1), and p27(Kip1) in carcino 11123420 Human
cyclin e benign tumors We induced rat mammary tumors in 7-week-old female Sprague-Dawley rats by intragastric administration of 7,12-dimethylbenz(a)anthracene (DMBA), and analyzed by immunohistochemistry the expression of cyclin D1, cyclin E, p21(Cip1), and p27(Kip1) in carcino 11123420 Human
cyclin e tumors The protein levels for cyclin D1, cyclin E and p21(Cip1) in carcinomas and atypical tumors were significantly higher than those in benign tumors, while normal mammary glands showed negligible expression. 11123420 Human
cyclin e carcinomas The protein levels for cyclin D1, cyclin E and p21(Cip1) in carcinomas and atypical tumors were significantly higher than those in benign tumors, while normal mammary glands showed negligible expression. 11123420 Human
cyclin e benign tumors The protein levels for cyclin D1, cyclin E and p21(Cip1) in carcinomas and atypical tumors were significantly higher than those in benign tumors, while normal mammary glands showed negligible expression. 11123420 Human
cyclin e tumors On RT-PCR, tumors showed higher mRNA levels of cyclin D1 and cyclin E than those of normal mammary glands. 11123420 Human
ccne endometrial carcinoma Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. 14648662 Human
cyclin e endometrial carcinoma Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. 14648662 Human
cyclin e endometrial carcinomas (ecs) Cyclin E overexpression occurs in a subset of endometrial carcinomas (ECs), but the molecular mechanisms underlying this alteration remain to be established. 14648662 Human
cyclin e endometrial carcinomas Cyclin E and p53 expression was studied by immunohistochemistry in eight atypical endometrial hyperplasias (AEHs), 51 endometrioid endometrial carcinomas (EECs), and 22 non-endometrioid endometrial carcinomas (NEECs). 14648662 Human
cyclin e endometrioid endometrial carcinomas Cyclin E and p53 expression was studied by immunohistochemistry in eight atypical endometrial hyperplasias (AEHs), 51 endometrioid endometrial carcinomas (EECs), and 22 non-endometrioid endometrial carcinomas (NEECs). 14648662 Human
cyclin e atypical endometrial hyperplasias (aehs) Cyclin E and p53 expression was studied by immunohistochemistry in eight atypical endometrial hyperplasias (AEHs), 51 endometrioid endometrial carcinomas (EECs), and 22 non-endometrioid endometrial carcinomas (NEECs). 14648662 Human
cyclin e tumour Although hCDC4 exhibits a low mutation frequency in ECs overexpressing cyclin E, it seems to function as a tumour suppressor gene that is involved in endometrial carcinogenesis. 14648662 Human
cyclin e cervical cancer These analyses, which showed close parallels in the timing and pattern of expression of cyclin E and Ki-67 in the mouse cervical disease compared with that in humans, provided further validation of this HPV-16 transgenic mouse model for human cervical can 14678972 Human
cyclin e cancer High levels of cyclin E expression are found in many types of cancer. 14510182 Human
cyclin e other cancers The link between cyclin E and poor prognosis is well established in breast and lung cancer but is likely to be observed in other cancers as well. 14510182 Human
cyclin e lung cancer The link between cyclin E and poor prognosis is well established in breast and lung cancer but is likely to be observed in other cancers as well. 14510182 Human
cyclin e gastric cancer Expression of cell-cycle regulatory proteins cyclin D1, cyclin E, and their inhibitor p21 WAF1/CIP1 in gastric cancer. 10547573 Human
cyclin e gastric carcinomas The expression and prognostic role of cyclin D1, cyclin E, and p21 (WAF1/CIP1) were immunohistochemically investigated in 413 curatively resected gastric carcinomas. p21 was expressed in 65.4 per cent (n=270), cyclin D1 in 23.7 per cent (n=98), and cyclin 10547573 Human
cyclin e tumours The expression and prognostic role of cyclin D1, cyclin E, and p21 (WAF1/CIP1) were immunohistochemically investigated in 413 curatively resected gastric carcinomas. p21 was expressed in 65.4 per cent (n=270), cyclin D1 in 23.7 per cent (n=98), and cyclin 10547573 Human
cyclin e gastric cancer The present data suggest that neither cyclin D1, cyclin E nor their inhibitor p21 can predict the survival of gastric cancer patients, nor is their immunohistochemical detection a suitable tool for identifying subgroups of patients who may be at higher ri 10547573 Human
cyclin e burkitts lymphoma In this study we investigated the cellular effects of olomoucine in two human Burkitt's lymphoma cell lines, WMN (containing wild-type p53) and CA46 (containing mutant p53), and found that in consistency with its ability to block the activity of cycl 10567774 Human
cyclin e breast tumors By analyzing the expression of p27 by immunohistochemistry in 100 primary breast tumors and combining the analyses with our earlier characterization of cyclin E, D1, p16, and the retinoblastoma protein (pRB), we have been able to cover the majority of pot 10573103 Human
cyclin e tumors By analyzing the expression of p27 by immunohistochemistry in 100 primary breast tumors and combining the analyses with our earlier characterization of cyclin E, D1, p16, and the retinoblastoma protein (pRB), we have been able to cover the majority of pot 10573103 Human
cyclin e retinoblastoma By analyzing the expression of p27 by immunohistochemistry in 100 primary breast tumors and combining the analyses with our earlier characterization of cyclin E, D1, p16, and the retinoblastoma protein (pRB), we have been able to cover the majority of pot 10573103 Human
cyclin e tumors Considerable variations in protein levels were found among tumors, with low p16 expression as the most common alteration followed by cyclin E or cyclin D1 overexpression, low p27 expression or pRB inactivation in decreasing prevalence. 10573103 Human
cyclin e tumors Tumors with high cyclin E/low p27 or pRB defects showed higher proliferation. 10573103 Human
cyclin e neuroblastoma Here we show that in Chinese hamster ovary (CHO) and neuroblastoma (N2A) cells, expression of cyclin E at the M/G1 transition is regulated by both growth factors and cell attachment, while expression of cyclin D seems to be entirely dependent on the prese 10585265 Human
cyclin e tumor Thus, ODC/polyamine-induced activation of cyclin E/Cdk2 and cyclin A/Cdk2-associated kinase activity may cooperate with the ras induction of cyclin D/Cdk4/6-associated retinoblastoma protein phosphorylation to not only stimulate proliferation but ultimate 10593650 Human
cyclin e carcinoma Expression of cyclin E in dysplasia, carcinoma, and nonmalignant lesions of Barrett esophagus. 10594854 Human
cyclin e invasive adenocarcinoma METHODS: Expression of the proliferation-associated molecule cyclin E was immunohistochemically determined in metaplastic specialized epithelium (SE; n = 24), low grade dysplasia (LGD; n = 21), high grade dysplasia (HGD; n = 17), and invasive adenocarcino 10594854 Human
cyclin e carcinoma The determination of cyclin E expression is therefore not useful in the identification of BE patients with an increased risk for the development of carcinoma. 10594854 Human
cyclin e primary malignant melanomas High levels of expression of p27KIP1 and cyclin E in invasive primary malignant melanomas. 10594749 Human
cyclin e tumors Importantly, most of the p21- and p27-positive tumors expressed high levels of cyclin D1 and cyclin E. 10594749 Human
cyclin e melanomas In proliferating cells p27 is predominantly associated with cyclin D-CDK4 complexes, but does not inhibit the kinase activity, whereas in quiescent cells p27 is found associated with inactive CDK2 complexes. p27 was also expressed at high levels in prolif 10594749 Human
cyclin e burkitts lymphoma Analysis of p27kip1 derived from Burkitt's lymphoma cell lines expressing high levels of p27kip1, BL40 and BL41, in a cyclin E/cdk2 kinase inhibition assay demonstrated that p27kip1 is not permanently inactivated since heat treatment can restore the 10597239 Human
cyclin e adenomas The levels of cyclin D1, cyclin E, p16, p21, p27, and p53 proteins were determined by immunohistochemistry in samples of normal small bowel (n = 16), small bowel adenomas (n = 20), and small bowel adenocarcinomas (n = 24). 10613343 Human
cyclin e small-bowel adenocarcinomas The levels of cyclin D1, cyclin E, p16, p21, p27, and p53 proteins were determined by immunohistochemistry in samples of normal small bowel (n = 16), small bowel adenomas (n = 20), and small bowel adenocarcinomas (n = 24). 10613343 Human
cyclin e non-hodgkins lymphomas To determine the relation of cyclin-dependent kinase inhibitors to histopathological grades of B-cell non-Hodgkin's lymphomas, the expression of p27, cyclin D1 and cyclin E in lymph node tissues was investigated in 56 patients with B-cell non-Hodgkin 10622539 Human
cyclin e lymphoma Cyclin E showed limited expression in 18 of 31 lymphoma tissues. 10622539 Human
cyclin e tumors Whereas cyclin E overexpression alone did not lead to an increased CDK2 activity we observed in all tumors that emerged from either MNU treated normal mice or treated CD2-cyclin E transgenics a downregulation of p27KIP1 and a higher histone H1 kinase acti 10618723 Human
cyclin e hyperplasia These findings demonstrate that high level expression of cyclin E can predispose T-cells for hyperplasia and malignant transformation. 10618723 Human
cyclin e gastric cancer This study was performed to determine whether two cell cycle regulators--p27 and cyclin E--provided prognostic information in gastric cancer patients. 10628377 Human
cyclin e gastric cancer MATERIALS AND METHODS: A total of 115 gastric cancer patients were eligible for this study from Jan. 1988 through Dec. 1994, and their paraffin blocks were chosen for immunohistochemical staining against p27 and cyclin E. RESULTS: Consequently, 35 patient 10628377 NA
cyclin e carcinoid tumor Inhibition of CDK2, CDK4 and cyclin E and increased expression of p27Kip1 during treatment with interferon-alpha in carcinoid tumor cells. 10703944 Human
cyclin e melanoma The molecular events that lead to melanoma cell autonomous growth are not well defined, but are likely to include sustained activity of cyclin-dependent kinases (CDK2, CDK4 and CDK6) as a result of loss of CDK inhibitors (such as p16INK4a and possibly p27 10721488 Human
cyclin e squamous-cell carcinomas The expression of p27 showed an inverse correlation with the expression of cyclin E in the squamous cell carcinomas and mucoepidermoid carcinomas. 10738177 Human
cyclin e mucoepidermoid carcinomas The expression of p27 showed an inverse correlation with the expression of cyclin E in the squamous cell carcinomas and mucoepidermoid carcinomas. 10738177 Human
cyclin e mucoepidermoid carcinoma These results suggest that the reduction of p27 protein may confer the development of oral squamous cell carcinoma and mucoepidermoid carcinoma partly through the increased expression of cyclin E. 10738177 Human
cyclin e oral squamous-cell carcinoma These results suggest that the reduction of p27 protein may confer the development of oral squamous cell carcinoma and mucoepidermoid carcinoma partly through the increased expression of cyclin E. 10738177 Human
cyclin e cancer Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy. 14508079 Human
cyclin e cancers The recent identification of key substrates for cyclin E-CDK2 complex has increased our appreciation of how cyclin E overexpression seen in many human cancers can lead to genomic instability, a feature that leads the tumor to a more aggressive state. 14508079 Human
cyclin e tumor The recent identification of key substrates for cyclin E-CDK2 complex has increased our appreciation of how cyclin E overexpression seen in many human cancers can lead to genomic instability, a feature that leads the tumor to a more aggressive state. 14508079 Human
cyclin e tumors In breast cancer, the identification of low molecular weight (LMW) forms of cyclin E generated specifically in tumors due to elastase mediated amino-terminal proteolytic processing opens new possibilities for a targeted treatment of breast cancer. 14508079 Human
cyclin e breast cancer In breast cancer, the identification of low molecular weight (LMW) forms of cyclin E generated specifically in tumors due to elastase mediated amino-terminal proteolytic processing opens new possibilities for a targeted treatment of breast cancer. 14508079 Human
cyclin e breast cancer Characterization of the biochemical properties of these LMW forms of cyclin E, in terms of substrate specificity, extent of their inhibition by the CDK inhibitors of the Cip/Kip family, their sensitivity to degradation, as well as elucidating their biolog 14508079 Human
cyclin e1 tumor Unlike cyclin E1, which is expressed in most proliferating normal and tumor cells, cyclin E2 levels were low to undetectable in nontransformed cells and increased significantly in tumor-derived cells. 9858585 Human
cyclin e gallbladder carcinomas Cyclin E overexpression in human gallbladder carcinomas. 9864408 Human
cyclin e gallbladder carcinomas The expression of cyclin E, one of the important positive cell cycle regulators, was examined immunohistochemically in gallbladder carcinomas. 9864408 Human
cyclin e tumor The degree of cyclin E expression was not associated with any clinicopathological factor including histology, the depth of tumor invasion, tumor stage and patient prognosis. 9864408 Human
cyclin e tumor Cyclin E expression was not correlated with that of p53 protein statistically, whereas it was correlated with the proliferative activity of the tumor cells by PCNA (p<0.05). 9864408 Human
cyclin e gallbladder carcinomas These results suggested that cyclin E expression may confer progression of gallbladder carcinomas. 9864408 Human
cyclin e gynecological cancers OBJECTIVE. This study investigated the patterns of expression of cyclin E in clear cell carcinoma and other gynecological cancers. 9889026 Human
cyclin e clear-cell carcinoma OBJECTIVE. This study investigated the patterns of expression of cyclin E in clear cell carcinoma and other gynecological cancers. 9889026 Human
cyclin e epithelial ovarian carcinomas RESULTS. Expression of cyclin E was evident in epithelial ovarian carcinomas utilizing immunohistochemistry. 9889026 Human
cyclin e clear-cell carcinomas Immunohistochemistry revealed a high level of expression of cyclin E in a subset of gynecologic carcinomas, namely clear cell carcinomas, but not in clear cell carcinomas of renal origin. 9889026 Human
cyclin e carcinomas Immunohistochemistry revealed a high level of expression of cyclin E in a subset of gynecologic carcinomas, namely clear cell carcinomas, but not in clear cell carcinomas of renal origin. 9889026 Human
cyclin e clear-cell carcinomas CONCLUSION. These data suggest that an elevated level of immunohistochemical activity of cyclin E is a property of clear cell carcinomas of Müllerian origin. 9889026 Human
cyclin e clear cell tumors Future studies are needed to confirm a possible increased activity of cyclin E in clear cell tumors. 9889026 Human
cyclin e carcinomas Western blot analysis showed an upregulation in the protein expression of cyclin D1 and cyclin E and their regulatory subunits cdk4 and cdk2 during the course of UVB exposure and in papillomas and carcinomas. 10022811 Human
cyclin e papillomas Western blot analysis showed an upregulation in the protein expression of cyclin D1 and cyclin E and their regulatory subunits cdk4 and cdk2 during the course of UVB exposure and in papillomas and carcinomas. 10022811 Human
cyclin e papillomas In this study, double immunofluorescence labeling unexpectedly revealed that E7 caused a concordant accumulation of both cyclin E and p21Cip1 to high levels in patient papillomas and in organotypic cultures of primary human keratinocytes. 10074904 Human
cyclin e epithelial ovarian carcinoma METHODS: In 51 cases of epithelial ovarian carcinoma, the expression of the cell proliferation marker Ki-67 and that of the cell cycle regulatory molecules p53, p16, p21, p27, cyclin E, and cyclin A was studied using immunohistochemical techniques. 10091740 Human
cyclin e clear-cell carcinoma RESULTS: Clear cell carcinoma revealed such trends as low expression of both p53 and cyclin A and significantly increased expression of both p21 and cyclin E (compared with the other histologic subtypes). 10091740 Human
cyclin e ovarian carcinomas In all ovarian carcinomas, a very strong positive correlation (correlation coefficient 0.79; P < 0.0001) between p53 positive staining and cyclin A positive staining and a weak positive correlation (correlation coefficient 0.47; P < 0.01) between p21 posi 10091740 Human
cyclin e cervical adenocarcinoma It was recently reported that cervical adenocarcinoma showed an abnormal expression of estrogen receptor (ER) and cell cycle-related molecules (cyclin E, p53, p16, p21, and p27). 10202666 Human
cyclin e gastric cancer Expression of cell-cycle regulators, cyclin E and p21WAF1/CIP1, potential prognostic markers for gastric cancer. 10218458 Human
cyclin e resected gastric cancers METHODS: In this study, we analysed the expression of cyclin D1, cyclin E, p21WAF1/CIP1 and p27KIP1 in 84 surgically resected gastric cancers by immunohistochemistry with long-term follow-up (median 38 months). 10218458 Human
cyclin e lymph-node metastasis Among the various clinicopathological findings, overexpression of cyclin E was associated with lymph-node metastasis (P=0.003) and recurrence (P=0.043). 10218458 Human
cyclin e gastric cancer CONCLUSIONS: These results suggest that immunohistochemical analysis for cell cycle regulators, especially cyclin E and p21WAF1/CIP1, might be a useful prognostic indicator in gastric cancer. 10218458 Human
cyclin e cancers Cyclin E in human cancers. 10224221 Human
cyclin e cancers Cyclin E may even be a target for treatment of cancers in the future. 10224221 Human
cyclin e epithelial ovarian carcinomas To further address alterations and roles of these cell-cycle proteins in the development of epithelial ovarian carcinomas, we analyzed the expression of the p27(kip1), cyclin D1, cyclin E, and cdk2. 10329035 Human
cyclin e ovarian carcinomas On the other hand, the expression of cyclin E and cdk2 was enhanced in ovarian carcinomas. 10329035 Human
cyclin e ovarian tumors The results suggest that low expression of p27(kip1) and cyclin D1 as well as high expression of cyclin E and cdk2 promotes the development of ovarian tumors. p27(kip1) and cyclin D1 expression are negatively correlated with the malignant degree of epithe 10329035 Human
ccne1 tumors The ERBB2 gene was amplified in 19 of 87 (21.8%), CCNE1 in 11 of 87 (12.6%), GATA4 in 9 of 87 (10.3%), KRAS in 9 of 87 (10.3%), EGFR in 7 of 87 (8.0%), CCND1 in 6 of 87 (6.8%), HNF3alpha in 5 of 87 (5.7%), PIK3CA in 5 of 87 (5.7%), C-MYC in 4 of 87 (4.6%) 14581353 Human
ccne1 barretts adenocarcinomas Increased copy number of the ERBB2 (1 of 22), GATA4 (1 of 22), KRAS (2 of 22), C-MYC (1 of 22), CCNE1 (2 of 22), and CCND1 (2 of 22) genes was also observed in one or more Barrett's adenocarcinomas with HGD. 14581353 Human
cyclin e b-chronic lymphocytic leukaemia Expression of cyclin E in resting and activated B-chronic lymphocytic leukaemia cells: cyclin E/cdk2 as a potential therapeutic target. 15059135 Human
cyclin e ovarian cancer Cyclin E deregulation alters the biologic properties of ovarian cancer cells. 15007381 Human
cyclin e ovarian cancer Here we investigate the biologic consequences of LMW cyclin E expression in ovarian cancer cells. 15007381 Human
cyclin e ovarian carcinoma Using a panel of ovarian carcinoma tumors we find that cyclin E overexpression is invariably due to the presence of LMW forms and that expression of these forms appears to correlate with more advanced grade and stage of disease. 15007381 Human
cyclin e tumors Using a panel of ovarian carcinoma tumors we find that cyclin E overexpression is invariably due to the presence of LMW forms and that expression of these forms appears to correlate with more advanced grade and stage of disease. 15007381 Human
cyclin e tumors Despite similar expression of p21 and p27, cyclin E overexpressing tumors have higher kinase function. 15007381 Human
cyclin e ovarian cancer Using an isogenic ovarian cancer model, we find that clones that overexpress the trunk 1 (T1) protein have a 10-fold increase in cyclin E kinase function, a 20% increase in S-phase fraction, a 10-15% decrease in doubling time and a 20% increase in colony 15007381 Human
cyclin e ovarian tumors Therefore, in ovarian tumors, the presence of LMW cyclin E forms confers altered biologic properties. 15007381 Human
cyclin e tumors Our data provides a potential mechanism for the poor prognosis of patients with LMW cyclin E expressing tumors. 15007381 Human
cyclin e mammary tumor Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E. 11803472 Human
cyclin e mammary tumor Significantly, 35% of mutant Neu/cyclin D1(-/-) mice regained mammary tumor potential due to compensation by cyclin E. Thus, shared targets of cyclins D1 and E are important in modulating Neu function in mammary tumorigenesis. 11803472 Human
cyclin e glioblastoma Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes. 10344736 Human
cyclin e invasive carcinoma Overexpression of cyclin D1, cyclin E, and p53 occurs frequently and independently in pulmonary SCC and is detected in lesions before the development of invasive carcinoma. 10344760 Human
cyclin e neoplasms The high ratio of p27 protein to cyclin E supports the excellent prognosis of these neoplasms, despite the presence of invasion and K-ras oncogene mutation. 10349991 Human
cyclin e human breast cancer Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation. 10353599 Human
cyclin e retinoblastoma Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation. 10353599 Human
cyclin e primary breast cancers In the present study we have determined the cyclin E dependent kinase activity (cyclin E(kinase)) in 59 primary breast cancers, using an H1-kinase assay, and related the activity to the expression of cyclin E, p27 and p21. 10353599 Human
cyclin e primary breast cancer Our results support that pRb is a substrate for cyclin E(kinase) in primary breast cancer and that deregulation of cyclin E and p27 act through increased CDK-kinase activity, but cyclin E associated events beside pRb phosphorylation might be rate-limiting 10353599 Human
cyclin e metastatic melanomas Cyclin E was not detected in benign naevi, but was easily detectable in most of the metastatic melanomas. 10380937 Human
cyclin e hepatocellular carcinomas (hcc) Expression of cell-cycle modulators at the G1-S boundary, retinoblastoma gene product (pRb), p21, p16, p27, p53, cyclin D1, and cyclin E was investigated with 104 hepatocellular carcinomas (HCC), as well as 90 of their adjacent noncancerous lesions and 9 10385644 Human
cyclin e retinoblastoma Expression of cell-cycle modulators at the G1-S boundary, retinoblastoma gene product (pRb), p21, p16, p27, p53, cyclin D1, and cyclin E was investigated with 104 hepatocellular carcinomas (HCC), as well as 90 of their adjacent noncancerous lesions and 9 10385644 Human
cyclin e oesophageal squamous cell carcinoma Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma. 10390005 Human
cyclin e tumour The expressions of cyclin D1, cyclin E, cyclin-dependent kinase 4 (CDK4), and CDK2 were immunohistochemically examined in 90 patients with human oesophageal squamous cell carcinoma (SCC) to determine their relationship to the tumour behaviour and patient 10390005 Human
cyclin e oesophageal squamous cell carcinoma The expressions of cyclin D1, cyclin E, cyclin-dependent kinase 4 (CDK4), and CDK2 were immunohistochemically examined in 90 patients with human oesophageal squamous cell carcinoma (SCC) to determine their relationship to the tumour behaviour and patient 10390005 Human
cyclin e tumours Nuclear immunostaining of cyclin D1 and cyclin E was observed in 28 (31.1%) and 27 tumours (30.0%) respectively. 10390005 Human
cyclin e tumours Our in vivo findings suggest that in human oesophageal SCC, cyclin D1 and cyclin E and their functional partners, CDK4 and CDK2, often exhibit dysregulated overexpression in many cases, and that tumours with simultaneous expression of cyclin D1 and CDK4 a 10390005 Human
cyclin e b-cell lymphomas These results could support the hypothesis that there are cyclin D3/p27 complexes in a subset of aggressive B-cell lymphomas in which p27 lacks the inhibitory activity found when it is bound to cyclin E/CDK2 complexes. 10397744 Human
cyclin e metastatic tumors Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma. 10425291 Human
cyclin e gastric carcinoma Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma. 10425291 Human
cyclin e tumor metastasis To clarify the role of cyclin E, CDK inhibitor p27Kip1 and their target molecule, E2F-1 in tumor metastasis, we examined immunohistochemically the expression of cyclin E, p27Kip1 and E2F-1 in 23 gastric carcinomas and metastatic tumors of the lymph node. 10425291 Human
cyclin e metastatic tumors To clarify the role of cyclin E, CDK inhibitor p27Kip1 and their target molecule, E2F-1 in tumor metastasis, we examined immunohistochemically the expression of cyclin E, p27Kip1 and E2F-1 in 23 gastric carcinomas and metastatic tumors of the lymph node. 10425291 Human
cyclin e gastric carcinomas To clarify the role of cyclin E, CDK inhibitor p27Kip1 and their target molecule, E2F-1 in tumor metastasis, we examined immunohistochemically the expression of cyclin E, p27Kip1 and E2F-1 in 23 gastric carcinomas and metastatic tumors of the lymph node. 10425291 Human
cyclin e primary tumor On the other hand, over 70% (17/23) and 50% (12/23) of the cases expressed cyclin E and E2F-1 at nearly the same levels in both primary tumor and lymph node metastasis, respectively. 10425291 Human
cyclin e lymph-node metastasis On the other hand, over 70% (17/23) and 50% (12/23) of the cases expressed cyclin E and E2F-1 at nearly the same levels in both primary tumor and lymph node metastasis, respectively. 10425291 Human
cyclin e non-small cell lung cancer In this study, we examined the mechanism by which t-RA blocks cell cycle progression in HBE cells and the possibility that this signaling event is blocked in non-small cell lung cancer (NSCLC) cells that are refractory to the growth inhibitory effects of 10447003 Human
cyclin e hyperplasia The results demonstrate that TGF-beta1-mediated conversion of hyperplasia to hypertrophy involves preventing activation of cdk2/cyclin E kinase but has no effect on cdk4(6)/cyclin D kinase activity. 10444572 Human
cyclin e tumours However, in many human tumours cyclin E is overexpressed and the levels of protein and kinase activity are often deregulated relative to the cell cycle. 10499591 Human
cyclin e transitional cell carcinoma Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival. 10514396 Human
cyclin e tumor Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival. 10514396 Human
cyclin e transitional cell carcinoma In this study we investigated the expression of two key cell cycle regulators, p27(Kip1) and cyclin E, in the progression of transitional cell carcinoma of the bladder. 10514396 Human
cyclin e bladder tumor An immunohistochemical analysis was conducted in a series of 50 bladder tumor specimens, including 3 metastatic lymph nodes, and 7 normal bladder specimens, using specific antibodies against the two regulators of the cell cycle, p27(Kip1) and cyclin E. 10514396 Human
cyclin e tumors Moreover, the expression of cyclin E was lower in grade III tumors compared to grade I and II lesions, although this difference failed to reach statistical significance. 10514396 Human
cyclin e bladder transitional cell carcinoma This is the first evidence that loss of expression of p27(Kip1) and cyclin E in human bladder transitional cell carcinoma cells correlates with advancing histological aggressiveness and poor patient survival. 10514396 Human
cyclin e tumors These results have clinical importance, because they support a role for p27(Kip1) and cyclin E as novel predictive markers of the biological potential of bladder tumors that will enable identification of those tumors most likely to progress to muscle inva 10514396 Human
cyclin e bladder tumors These results have clinical importance, because they support a role for p27(Kip1) and cyclin E as novel predictive markers of the biological potential of bladder tumors that will enable identification of those tumors most likely to progress to muscle inva 10514396 Human
cyclin e lung cancer The expression of another G1 cyclin, cyclin E, was not regulated by mimosine in all lung cancer cell lines examined. 10530763 Human
cyclin e cancer However, our laboratory found that a variety of human cancer cell lines express relatively high levels of this protein and that this is often associated with increased expression of cyclin D1 or cyclin E. Therefore, in the present study we analyzed by imm 9426067 Human
cyclin e adenomatous polyps However, our laboratory found that a variety of human cancer cell lines express relatively high levels of this protein and that this is often associated with increased expression of cyclin D1 or cyclin E. Therefore, in the present study we analyzed by imm 9426067 Human
cyclin e colorectal carcinomas However, our laboratory found that a variety of human cancer cell lines express relatively high levels of this protein and that this is often associated with increased expression of cyclin D1 or cyclin E. Therefore, in the present study we analyzed by imm 9426067 Human
cyclin e hyperplastic polyps However, our laboratory found that a variety of human cancer cell lines express relatively high levels of this protein and that this is often associated with increased expression of cyclin D1 or cyclin E. Therefore, in the present study we analyzed by imm 9426067 Human
cyclin e ovarian cancer Analysis of cyclin E and CDK2 in ovarian cancer: gene amplification and RNA overexpression. 9426687 Human
cyclin e ovarian cancer We have studied the role of both cyclin E and its associated kinase cdk2 in ovarian cancer. 9426687 NA
cyclin e benign ovarian tumors Primary, metastatic, recurrent and benign ovarian tumors were screened for cyclin E and cdk2 gene amplification. 9426687 Human
cyclin e ovarian tumors Cyclin E RNA was overexpressed in 29.5% and cdk2 in 6.5% of ovarian tumors tested. 9426687 Human
cyclin e ovarian tumor We hypothesize that cyclin E and cdk2 are, in part co-regulated and that they may concur to ovarian tumor development. 9426687 Human
cyclin e hepatic tumors Cyclin E overexpression responsible for growth of human hepatic tumors with p21WAF1/CIP1/SDI1. 9446792 Human
cyclin e liver tumor These findings indicate that the human liver tumor cell lines which have the p21WAF1/CIP1/SDI1-inducible barriers of the cell cycle progression can go through the G1/S checkpoint by overexpressing cyclin E. 9446792 Human
cyclin e tumor A statistically significantly higher expression of cyclin E oncogene and MTS1 tumor suppressor gene was seen in type III DCIS than in the other types, while no significant differences in the mRNA expression patterns of the other genes were observed. 9504854 Human
cyclin e carcinoma of the renal pelvis and ureter Prognostic significance of cyclin E and p53 protein overexpression in carcinoma of the renal pelvis and ureter. 9514058 Human
cyclin e transitional cell carcinoma (tcc) We immunohistochemically examined the expression of cyclin E and p53 proteins in 121 patients with transitional cell carcinoma (TCC) of the renal pelvis and ureter to determine their significance for tumour behaviour and patient prognosis. 9514058 Human
cyclin e tumour We immunohistochemically examined the expression of cyclin E and p53 proteins in 121 patients with transitional cell carcinoma (TCC) of the renal pelvis and ureter to determine their significance for tumour behaviour and patient prognosis. 9514058 Human
cyclin e tumours Cyclin E and p53 immunostaining of the nucleus was observed in 36 tumours (29.8%) and 35 tumours (28.9%) respectively. 9514058 Human
cyclin e cancer Mirror-section technique was performed in five selected double-positive tumours to identify cancer cells that were nuclei positive for both cyclin E and p53. 9514058 Human
cyclin e tumours Mirror-section technique was performed in five selected double-positive tumours to identify cancer cells that were nuclei positive for both cyclin E and p53. 9514058 Human
cyclin e tumours The prevalence of cases simultaneously exhibiting both cyclin E and p53 immunostaining was higher in the high-grade tumours (P < 0.01) than in the other types of tumours. 9514058 Human
cyclin e tumour These in vivo findings provide evidence for cyclin E protein overexpression in TCCs intimately associated with p53 alteration and suggest that simultaneous overexpression of both cyclin E and p53 is related to tumour behaviour and poor prognosis. 9514058 Human
cyclin e gastric carcinoma Prognostic value of cyclin E and p53 expression in gastric carcinoma. 9529014 Human
cyclin e cancers Cyclin E is a late G1 cyclin and its abnormalities have been reported in several cancers. 9529014 Human
cyclin e gastric carcinoma The authors investigated the correlation between cyclin E expression and progression of gastric carcinoma. 9529014 Human
cyclin e gastric carcinoma METHODS: The expression of cyclin E and p53 proteins was investigated retrospectively in 116 patients with gastric carcinoma. 9529014 NA
cyclin e tumors Strong cyclin E expression frequently was observed in deeply invasive tumors, tumors with lymph node metastasis, and tumors of advanced stage. 9529014 Human
cyclin e lymph-node metastasis Strong cyclin E expression frequently was observed in deeply invasive tumors, tumors with lymph node metastasis, and tumors of advanced stage. 9529014 Human
cyclin e other tumors The incidence of p53 expression was higher in the cyclin E positive tumors than in the other tumors. 9529014 Human
cyclin e tumors The incidence of p53 expression was higher in the cyclin E positive tumors than in the other tumors. 9529014 Human
cyclin e tumors With regard to prognosis, patients whose tumors had both strong positivity for cyclin E and positivity for p53 had significantly poorer prognosis. 9529014 Human
cyclin e tumor In multivariate analysis, the combined variable of cyclin E and p53 was an independent prognostic indicator together with serosal invasion and tumor size. 9529014 Human
cyclin e gastric carcinoma CONCLUSIONS: These data suggest the cyclin E expression correlates with p53 expression and may contribute to the progression of gastric carcinoma. 9529014 Human
cyclin e gastric carcinoma The combined variable of cyclin E and p53 expression could be a useful prognostic indicator in patients with gastric carcinoma. 9529014 Human
cyclin e condyloma acuminatum (ca) In order to determine whether cyclin D1 or cyclin E deregulation is also a feature of HPV infection, an immunohistochemical investigation of cyclin D1, cyclin E, Ki67, and PCNA expression has been carried out in 38 cases of HPV 6/11-related condyloma acum 9582532 Human
cyclin e human thyroid carcinomas Cyclin D1 and Cyclin E expression in malignant thyroid cells and in human thyroid carcinomas. 9626345 Human
cyclin e thyroid tumors Neither major genetic alterations nor amplifications for cyclin D1 and cyclin E genes were found by Southern blot analysis in genomic DNAs extracted from all types of thyroid tumors. 9626345 Human
cyclin e thyroid papillary carcinomas Our in vivo observations suggest that unlike cyclin E, elevated nuclear cyclin D1 expression defines a subset of thyroid papillary carcinomas, and might be a contributory factor to thyroid tumorigenesis. 9626345 Human
cyclin e tumor In contrast, the transformed fibroblasts and tumor cells, which are anchorage-independent, had more than half of their cyclin E, cdk2, p21 and p27 in the cytoplasmic fraction, both in attached and suspended cultures. 9632134 Human
cyclin e adenocarcinoma of the uterine cervix METHODS: In 40 cases of adenocarcinoma of the uterine cervix and 10 normal cervices, expression of estrogen receptor and cell cycle regulatory gene products (cyclin E, p16, p21WAF1/CIP1, p27, p53, and Ki-67) was studied using immunohistochemical technique 9635534 NA
cyclin e carcinoma Relative to the mean expression levels in cultured normal cell populations, expression of c-myc, E2F-1, PCNA, cyclin E, and CDK4 messenger RNA (mRNA) were significantly increased and expression of p21 and p53 mRNA were significantly decreased in one or tw 9651176 Human
cyclin e adenocarcinoma Relative to the mean expression levels in cultured normal cell populations, expression of c-myc, E2F-1, PCNA, cyclin E, and CDK4 messenger RNA (mRNA) were significantly increased and expression of p21 and p53 mRNA were significantly decreased in one or tw 9651176 Human
cyclin e tumor Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. 9660822 Human
cyclin e osteosarcoma Prolonged activation of c-Fos resulted in osteosarcoma formation wherein the levels of cyclin D1, cyclin E, and CDKs 2, 4, and 6 were high in a wide spectrum of malignant cell types, especially in transformed osteoblasts. 9664690 Human
cyclin e osteosarcoma These in vivo observations suggest that cyclin D1 may be a target for c-Fos action and that elevation of cyclin D1 in osteoblasts which already express cyclin E/CDK2 and the cyclin D1 partners CDKs-4 and 6, may predispose cells to uncontrolled cell growth 9664690 Human
cyclin e hematopoietic malignancies Flow cytometric quantification of cyclin E in human cell lines and hematopoietic malignancies. 9667511 Human
cyclin e hematological malignancies In this study, the expression of cyclin E was analyzed in 12 human cell lines and 18 hematological malignancies by flow cytometry, and protein levels were quantified using calibrating microbeads. 9667511 Human
cyclin e tumor Similar cyclin E levels were observed in the tumor samples as for the cell lines, although the fractions of positive cells were low. 9667511 Human
cyclin e carcinoma Immunoreactivity for cyclin E, cdk2, and cdk4 was detected in carcinoma cells of 37/39 (95%), 39/39 and 36/39 cases, respectively. 9673386 Human
cyclin e malignant lymphomas To investigate the importance of cell-cycle defects in malignant lymphomas we have characterized the expression of cyclin E and p27 in 105 newly diagnosed lymphomas using immunohistochemistry. 9680343 Human
cyclin e lymphomas To investigate the importance of cell-cycle defects in malignant lymphomas we have characterized the expression of cyclin E and p27 in 105 newly diagnosed lymphomas using immunohistochemistry. 9680343 Human
cyclin e esophageal squamous-cell carcinoma In the present study, we examined the relationships between immunohistochemically detected expression of p27, cyclin D1, cyclin E proteins and clinicopathological findings in 77 patients with esophageal squamous cell carcinoma (SCC). 9699540 Human
cyclin e hepatocellular carcinoma Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma. 9722210 Human
cyclin e tumor Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma. 9722210 Human
cyclin e hepatocellular carcinomas Cyclin E mRNA was overexpressed in 40 hepatocellular carcinomas, regardless of tumor size. 9722210 Human
cyclin e tumor Cyclin E mRNA was overexpressed in 40 hepatocellular carcinomas, regardless of tumor size. 9722210 Human
cyclin e hepatocellular carcinoma Overexpression of cyclin E was significantly associated with poorly differentiated and invasive hepatocellular carcinoma (p=0.001 and p=0.015, respectively). 9722210 Human
cyclin e large hepatocellular carcinoma Hepatocellular carcinomas expressing both downregulation of cyclin D1 and overexpression of cyclin E had the worst 4-year survival (p<0.03), and higher frequencies of the p53 mutation (p<0.001), large hepatocellular carcinoma (p<0.001), and invasive tumor 9722210 Human
cyclin e hepatocellular carcinomas Hepatocellular carcinomas expressing both downregulation of cyclin D1 and overexpression of cyclin E had the worst 4-year survival (p<0.03), and higher frequencies of the p53 mutation (p<0.001), large hepatocellular carcinoma (p<0.001), and invasive tumor 9722210 Human
cyclin e tumor Hepatocellular carcinomas expressing both downregulation of cyclin D1 and overexpression of cyclin E had the worst 4-year survival (p<0.03), and higher frequencies of the p53 mutation (p<0.001), large hepatocellular carcinoma (p<0.001), and invasive tumor 9722210 Human
cyclin e hepatocellular carcinoma Overexpression of cyclin E occurs early, and downregulation of cyclin D1 late in hepatocellular carcinoma growth. 9722210 Human
cyclin e human hepatoma Phosphorylation of cyclin E, inhibition of cyclin-dependent kinase 2 activity, and degradation of cyclin E were found in human hepatoma Hep G2 cells during apoptosis. 9726816 Human
cyclin e tumor In particular, well differentiated cells in squamous cell carcinoma stained positively for cyclin E; in contrast, cyclin A was expressed in the nonkeratinized proliferating areas of the tumor nests. 9736045 Human
cyclin e squamous-cell carcinoma In particular, well differentiated cells in squamous cell carcinoma stained positively for cyclin E; in contrast, cyclin A was expressed in the nonkeratinized proliferating areas of the tumor nests. 9736045 Human
cyclin e tumor Immunoprecipitation also revealed higher levels of cyclin A and cyclin E associated with CDK2 in tumor tissues. 9736045 Human
cyclin e tumors BACKGROUND/AIMS: Alterations in p27(Kip1) (p27) and cyclin E (cycE) expression are found in tumors and are related to poor prognosis. 12713869 Human
cyclin e invasive breast cancer As also observed in invasive breast cancer, there was a trend indicating that DCIS cases with high cyclin D1 were cyclin E low and oestrogen receptor-positive, whereas cyclin E high DCIS cases were cyclin D1 low and oestrogen receptor-negative. 14612904 Human
cyclin e tumor TGF-beta1 treatment increased the association of p21WAF1/Cip1/Sdi1 with the Cdk2/cyclin E complex in both normal and prostate tumor cells. 9794232 Human
cyclin e tumor In contrast, although there was an increase in the association of p21WAF1/Cip1/Sdi1 with the Cdk2/cyclin E complex in tumor cells, there was no inhibition of the Cdk2 activity. 9794232 Human
cyclin e tumors We performed immunohistochemical analysis with antibodies directed against Ki67 (MIB1), cyclin A, and cyclin E on 44 renal tumors, including 2 metanephric adenomas, 9 oncocytomas, and 33 renal cell carcinomas, including 10 clear cell, 11 papillary, 6 chro 9796723 Human
cyclin e renal tumors We performed immunohistochemical analysis with antibodies directed against Ki67 (MIB1), cyclin A, and cyclin E on 44 renal tumors, including 2 metanephric adenomas, 9 oncocytomas, and 33 renal cell carcinomas, including 10 clear cell, 11 papillary, 6 chro 9796723 Human
cyclin e metanephric adenomas We performed immunohistochemical analysis with antibodies directed against Ki67 (MIB1), cyclin A, and cyclin E on 44 renal tumors, including 2 metanephric adenomas, 9 oncocytomas, and 33 renal cell carcinomas, including 10 clear cell, 11 papillary, 6 chro 9796723 Human
cyclin e renal-cell carcinomas We performed immunohistochemical analysis with antibodies directed against Ki67 (MIB1), cyclin A, and cyclin E on 44 renal tumors, including 2 metanephric adenomas, 9 oncocytomas, and 33 renal cell carcinomas, including 10 clear cell, 11 papillary, 6 chro 9796723 Human
cyclin e human gastric carcinoma Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance. 9811181 Human
cyclin e gastric carcinoma We investigated the expression of cyclin D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining and also the relevance of each cyclin expression to the clinical outcomes. 9811181 Human
cyclin e gastric cancer Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of 84 (40.5%) gastric cancer tissues, respectively. 9811181 Human
cyclin e lymph-node metastasis There was a significant correlation between overexpression of cyclin E and lymph node metastasis (p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall survival (p=0.0319), but no correlation was noted between overexpression of cycl 9811181 Human
cyclin e gastric cancer These findings suggest that overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer and immunohistochemical analysis for cell cycle regulators, especially cyclin E might be a useful prognostic indicator in gastric cancer. 9811181 Human
cyclin e cancers G1 cyclin E controls the initiation of DNA synthesis by activating CDK2, and abnormally high levels of cyclin E expression have frequently been observed in human cancers. 9840943 Human
cyclin e carcinomas Cyclin E staining was nuclear in distribution, and the frequency of positive staining, ie., moderate or strong intensity, was significantly higher (P < .001 for cyclin E staining vs. diagnosis) in all of the lesional epithelia (92.3, 51.6, and 50% of low- 9872657 Human
cyclin e retinoblastoma Increased cyclin E level in retinoblastoma cells during programmed cell death. 9874510 Human
cyclin e cervical neoplasms Association of p27Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms. 9891436 Human
cyclin e cancer Recent studies demonstrated that a variety of human cancer cell lines express relatively high levels of p27Kip1 and that this might be associated with increased expression of Cyclin E. 9891436 Human
cyclin e invasive squamous cell carcinoma This study analyzed by immunohistochemistry the expression of p27Kip1, Cyclin E and c-myc in a series of HPV-positive cervical tissue samples representing various stages of cervical carcinogenesis, using 13 samples of normal epithelium, 24 low-grade CIN, 9891436 Human
cyclin e invasive carcinomas Cyclin E and c-myc were positively correlated to cell proliferation in pre-cancerous lesions, but not related to overall survival in invasive carcinomas. 9891436 Human
cyclin e ductal carcinoma in situ (dcis) Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. 10066069 Human
cyclin e breast cancer Cyclin E expression and proliferation in breast cancer. 10221332 Human
cyclin e breast cancer Cyclin E is a part of the cell cycle machinery and aberrantly expressed in several malignancies including breast cancer. 10221332 Human
cyclin e tumours Since cyclin E is cell cycle specifically expressed, we wanted to examine the relation between proliferation and expression of cyclin E with special attention to tumours with overexpression of the protein. 10221332 Human
cyclin e tumours Seventy-four breast tumours were analysed for the expression of cyclin E by immunohistochemistry and Western blotting and related to the growth fraction determined by Ki-67. 10221332 Human
cyclin e breast cancer The majority of the tumours had less cyclin E than Ki-67 positive cells indicating a conserved cell cycle specific expression of the protein which further was supported by flow cytometric analysis of breast cancer cell lines. 10221332 Human
cyclin e tumours The majority of the tumours had less cyclin E than Ki-67 positive cells indicating a conserved cell cycle specific expression of the protein which further was supported by flow cytometric analysis of breast cancer cell lines. 10221332 Human
cyclin e tumours The cell cycle specificity of cyclin E was found even in tumours with inactivated retinoblastoma protein (pRB) demonstrating the existence of a pRB independent regulation of cyclin E. 10221332 Human
cyclin e other tumours A fraction of the tumours had considerably elevated cyclin E levels that were not in relation to the proliferative activity as observed for the other tumours. 10221332 Human
cyclin e tumours A fraction of the tumours had considerably elevated cyclin E levels that were not in relation to the proliferative activity as observed for the other tumours. 10221332 Human
cyclin e tumours These tumours were in general highly proliferative and considered to overexpress cyclin E. 10221332 Human
cyclin e breast cancer Patients with tumours of high proliferative activity, high total cyclin E levels or disproportionally elevated cyclin E expressions in relation to proliferation had significantly increased risk of death in breast cancer, whereas the intensity of the immun 10221332 Human
cyclin e tumours Patients with tumours of high proliferative activity, high total cyclin E levels or disproportionally elevated cyclin E expressions in relation to proliferation had significantly increased risk of death in breast cancer, whereas the intensity of the immun 10221332 Human
cyclin e carcinomas Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. 8972226 Human
cyclin e hyperplasia Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. 8972226 Human
cyclin e human breast cancer In particular, a strong correlation has been established between inappropriate cyclin E expression and human breast cancer. 8972226 Human
cyclin e hyperplasia Lactating mammary glands of transgenic mice expressing cyclin E contained areas of hyperplasia, primarily papillary projections of hyperplastic cells, which were rarely observed in lactating glands of control mice. 8972226 Human
cyclin e mammary carcinomas Over 10% of female cyclin E transgenic mice have developed mammary carcinomas, with latencies ranging from 8 to 13 months. 8972226 Human
cyclin e tumor Tumor analysis revealed the presence of transgene-specific cyclin E RNA and protein, as well as cyclin E- and cdk2-associated kinase activity, suggesting that cyclin E is likely a contributing component of tumorigenic progression in this model system. 8972226 Human
cyclin e tumors Overexpression of cyclin D1 and/or cyclin E, in combination with a normal pRB, was a typical feature of tumors with high telomerase activity levels. 9012489 Human
cyclin e breast cancer Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein. 9018115 Human
cyclin e tumours Twenty-five out of 34 tumours with overexpression of cyclin E showed uniform low cyclin D1 expression, and by immunohistochemical analysis of pRB we present evidence for the existence of pRB defects in approximately 40% of these tumours in contrast to no 9018115 Human
cyclin e tumours This result was supported by a high protein expression of the cyclin-dependent kinase inhibitor p16 in 44% of the tumours with high cyclin E and low D1 expression, and all immunohistochemical pRB defect tumours showed a high p16 protein level. 9018115 Human
cyclin e tumours Interestingly, tumours with high cyclin E and low D1 expression were generally oestrogen receptor negative suggesting a role for cell cycle regulators in the mechanisms leading to oestrogen independent tumour growth. 9018115 Human
cyclin e tumour Interestingly, tumours with high cyclin E and low D1 expression were generally oestrogen receptor negative suggesting a role for cell cycle regulators in the mechanisms leading to oestrogen independent tumour growth. 9018115 Human
cyclin e breast cancer Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. 9018243 Human
cyclin e tumor However, tumor-specific mutations are uncommon in genes encoding cyclin E and the CDK inhibitor p27Kip1, two cell-cycle regulators that are also thought to contribute to tumor progression. 9018243 Human
cyclin e tumors Thus, changes in p27 and cyclin E protein levels in tumors might be more common than previously anticipated and may be indicators of tumor behavior. 9018243 Human
cyclin e tumor Thus, changes in p27 and cyclin E protein levels in tumors might be more common than previously anticipated and may be indicators of tumor behavior. 9018243 Human
cyclin e adenocarcinomas The cyclin E mRNA level was increased 2.7-fold in adenomas and 3.3-fold in adenocarcinomas (p<0.05). 14614307 Human
cyclin e adenomas The cyclin E mRNA level was increased 2.7-fold in adenomas and 3.3-fold in adenocarcinomas (p<0.05). 14614307 Human
cyclin e adenocarcinomas Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E expression was detected in 87.5% of the adenomas and in 92.3% of the adenocarcinomas. 14614307 Human
cyclin e adenomas Cyclin D1 expression was detected in 56.3% of the adenomas and in 61.5% of the adenocarcinomas examined, whereas cyclin E expression was detected in 87.5% of the adenomas and in 92.3% of the adenocarcinomas. 14614307 Human
cyclin e adenocarcinomas Overall, cyclin D1, cyclin E and PCNA expression was significantly increased at both the mRNA and protein levels in normal colonic mucosa, adenomas and adenocarcinomas, but there was no significant difference in the degree of expression of these genes in 14614307 Human
cyclin e adenomas Overall, cyclin D1, cyclin E and PCNA expression was significantly increased at both the mRNA and protein levels in normal colonic mucosa, adenomas and adenocarcinomas, but there was no significant difference in the degree of expression of these genes in 14614307 Human
cyclin e adenomas Our results indicate that the overexpression of cyclin D1 and cyclin E may play an important role during the multistage process of rat colon carcinogenesis, at a relatively early stage, and may disturb cell-cycle control in benign adenomas, and thereafter 14614307 Human
cyclin e tumor Our results indicate that the overexpression of cyclin D1 and cyclin E may play an important role during the multistage process of rat colon carcinogenesis, at a relatively early stage, and may disturb cell-cycle control in benign adenomas, and thereafter 14614307 Human
cyclin e hepatocellular carcinoma Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance. 14606074 Human
cyclin e metastasis The overexpressions of cyclin E and cyclin A were correlated with differentiation, tumor thrombus, invasiveness and metastasis (P<0.05). 14606074 Human
cyclin e tumor thrombus The overexpressions of cyclin E and cyclin A were correlated with differentiation, tumor thrombus, invasiveness and metastasis (P<0.05). 14606074 Human
cyclin e metastasis CONCLUSION: p27, cyclin E, cyclin A play cooperative roles in HCC tumorigenesis, differentiation, invasiveness and metastasis. 14606074 Human
cyclin e human tumors Human tumors often display increased expression of cyclin E, suggesting that this might contribute to their abnormal growth. 9101085 Human
cyclin e human tumors Therefore, additional studies are required to better understand the significance of the frequent increase of cyclin E expression in human tumors. 9101085 Human
cyclin e mammary carcinomas Resistance of mammary carcinomas to growth inhibition by IFNgamma does not appear to involve resistance of cdk2 complexes to the action of p27, but rather an inability to appropriately regulate the balance of cdk2, cyclin E and p27 levels. 9160891 Human
cyclin e sarcoma The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. 12824885 Human
cyclin e soft-tissue sarcomas The aim of the present study was to examine the prognostic significance of p27(Kip1) and cyclin E expression in patients with spindle-cell soft tissue sarcomas. 12824885 Human
cyclin e sarcoma In 46 cases of spindle-cell sarcoma including 17 pre-operative biopsy materials, the expression of p27(Kip1) and cyclin E was immunohistochemically examined. 12824885 Human
cyclin e primary tumor The expression of p27(Kip1) decreased in the nuclei of metastatic primary tumor cells (stage IV), whereas the expression of cyclin E increased in those lesions. 12824885 Human
cyclin e sarcoma On univariate analysis, when the expression of p27(Kip1) and cyclin E was analyzed together, patients with spindle-cell sarcoma exhibiting low expression of p27(Kip1) and high expression of cyclin E showed lower distant-metastasis-free survival (DMFS) and 12824885 Human
cyclin e sarcoma These results suggest that the combination analysis of p27(Kip1) and cyclin E expression even in biopsy specimens allows the prediction of the clinical behavior of spindle-cell sarcoma. 12824885 Human
cyclin e cutaneous squamous cell carcinomas Less expression of cyclin E in cutaneous squamous cell carcinomas than in benign and premalignant keratinocytic lesions. 9194584 Human
cyclin e breast cancer Another G1 cyclin, cyclin E, was recently suggested to be a prognostic marker for breast cancer. 9194584 Human
cyclin e keratoacanthoma In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e seborrheic keratosis (sk) In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e squamous cell carcinoma (scc) In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e basal-cell carcinoma (bcc) In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e tumors These results suggest that expression of cyclin E plays a role in the formation of benign and premalignant keratinocytic tumors, whereas down-regulation of cyclin E expression may be involved in carcinogenesis in human keratinocytes. 9194584 Human
cyclin e tumours However, cyclin E and Cdk2-which promote phosphorylation of pRB-were expressed in all tumours. 9215124 Human
cyclin e breast cancer CONCLUSIONS: The phosphorylation of pRB appears to be regulated mainly by p21/Cip1 through the suppression of cyclin E and Cdk2 in breast cancer. 9215124 Human
cyclin e metastasis Nodal metastasis correlated with cyclin D1 (p = 0.045), cyclin E (p = 0.037), urokinase-type plasminogen activator (p = 0.047), and PDGF-A (p = 0.003) mRNA. 9242335 Human
cyclin e acute myelogenous leukemia Overexpression of cyclin E in acute myelogenous leukemia. 9345056 Human
cyclin e leukemia Overexpression of cyclin E protein has been reported in several solid tumors, but little is known about the involvement of cyclin E in leukemia. 9345056 Human
cyclin e solid tumors Overexpression of cyclin E protein has been reported in several solid tumors, but little is known about the involvement of cyclin E in leukemia. 9345056 Human
cyclin e acute myelogenous leukemia (aml) In this study, we analyzed the expression of cyclin E gene product in 85 patients with acute myelogenous leukemia (AML) by Western blot analysis. 9345056 Human
cyclin e m5 leukemia The rates of complete remission and of disease-free survival of the patients with M4 or M5 leukemia blasts with overexpressed cyclin E seemed to be low. 9345056 Human
cyclin e tumor In the present study, we evaluated the oncogenic potential of cyclin D1 in experimental rat urinary bladder carcinogenesis and its relationships to the oncogenes cyclin E, K-ras, and H-ras as well as tumor suppressor genes p53 and p21WAF1/Cip1. 9354438 Human
cyclin e tumors Quantitation of mRNA in tumors by multiplex reverse transcription-PCR showed that average mRNA expression of cyclin D1 and cyclin E was increased, whereas average p21WAF1/Cip1 mRNA expression was decreased. 9354438 Human
cyclin e breast cancer Lack of cyclin E immunoreactivity in non-malignant breast and association with proliferation in breast cancer. 9374373 Human
cyclin e breast carcinomas Previous immunohistochemical and immunoblotting studies have investigated the expression of cyclin E in breast carcinomas. 9374373 Human
cyclin e epithelial neoplasms Cyclin E expression in benign and malignant epithelial neoplasms of the gallbladder. 9409193 Human
cyclin e tumors Many tumors, such as colon, breast and gastric carcinomas are known to be involved in the deregulation or amplification of cyclins, especially cyclin E, which involves the restriction point of G1-S transition. 9409193 Human
cyclin e gastric carcinomas Many tumors, such as colon, breast and gastric carcinomas are known to be involved in the deregulation or amplification of cyclins, especially cyclin E, which involves the restriction point of G1-S transition. 9409193 Human
cyclin e epithelial tumors We investigated the expression of cyclin E in benign and malignant epithelial tumors of the gallbladder and compared the results with the activity of cell proliferation by the Ki67 antigen using immunohistochemical staining. 9409193 Human
cyclin e adenoma Cyclin E was expressed in the adenocarcinoma tissue in 33.3% of patients (4 out of 12 cases), whereas only one out of 8 cases of adenoma expressed cyclin E (12.5%). 9409193 Human
cyclin e adenocarcinoma Cyclin E was expressed in the adenocarcinoma tissue in 33.3% of patients (4 out of 12 cases), whereas only one out of 8 cases of adenoma expressed cyclin E (12.5%). 9409193 Human
cyclin e adenocarcinoma These results suggest that the high expression of cyclin E in adenocarcinoma of the gallbladder is related to a high rate of cell proliferation. 9409193 Human
cyclin e carcinoma Immunoreactivity for cyclin E and cdk2 was detected in all the cases and observed in the nuclei of both carcinoma and non-carcinoma cells. cdk4 immunoreactivity was detected in 39/41 (95%) cases and found in carcinoma and non-carcinoma cells. 9413224 Human
cyclin e invasive ductal and lobular carcinoma These results also indicate different patterns of cyclin D1, cyclin E, cdk2 and cdk4 expression between invasive ductal and lobular carcinoma of human breast. 9413224 Human
cyclin e cancer The role of cyclin E in cell proliferation, development and cancer. 9552414 Human
cyclin e cancers The deregulation in the expression and activity of cyclin E has been associated with a number of cancers and is thought to be involved in the process of oncogenesis. 9552414 Human
cyclin e cancer In this chapter, we summarise the current knowledge on the regulation and apparent function of cyclin E in normal proliferating cells and in developing tissue and alterations of these processes in cancer. 9552414 Human
cyclin e cancer Amplification and/or overexpression of the cyclin D1 gene and aberrant expression of cyclin E have been described in several forms of human cancer. 9604788 Human
cyclin e carcinomas Six out of eight carcinomas examined showed a four to nine fold increase in cyclin E mRNA and about 50% of the carcinomas displayed a two to three fold increase in cyclin E protein. 9604788 Human
cyclin e colon carcinomas None of the primary colon carcinomas nor the six cell lines examined displayed amplification of either the cyclin D1 or cyclin E genes. 9604788 Human
cyclin e myxofibrosarcoma In this study, we evaluated the expression of p53, MDM2, MIB-1 (Ki-67), p21, p27, p16, cyclin A, cyclin D1, and cyclin E by immunohistochemistry in 45 cases of myxofibrosarcoma. 14608538 Human
cyclin e cancer Cyclin E was higher in the cancer tissue than in the non-neoplastic mucosa in 92% patients (35 out of 38 cases). 8576279 Human
cyclin e cancer These results proved that colorectal cancers express high levels of cyclin E, consistent with a high rate of cell proliferation, whereas most of such cancer lose control of cyclin A and cyclin D1 expression. 8576279 Human
cyclin e colorectal cancers These results proved that colorectal cancers express high levels of cyclin E, consistent with a high rate of cell proliferation, whereas most of such cancer lose control of cyclin A and cyclin D1 expression. 8576279 Human
cyclin e relapsed adult acute lymphoblastic leukemias Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage. 8605353 Human
cyclin e acute lymphoblastic leukemia Using Western blot analysis, we examined cyclin E and cyclin A protein levels in 19 patients with acute lymphoblastic leukemia ([ALL] 15 B-ALL and four T-ALL). 8605353 Human
cyclin e burkitts lymphoma Whereas normal, nonproliferating peripheral blood mononuclear cells (PBMCs) expressed low levels of the 50-kD cyclin E, ALL blasts in the peripheral blood, although showing low-level or no proliferation as judged by FACS/cell-cycle analysis and cyclin A p 8605353 Human
cyclin e breast cancer Cyclin E -- a better prognostic marker for breast cancer than cyclin D? 8612208 Human
cyclin e uterine endometrioid carcinoma Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. 8625241 Human
cyclin e tumor Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. 8625241 Human
cyclin e cancer Furthermore, the cells with weak or negative staining for p53 had a tendency to stain positively for Rb and weakly positive for cyclin E, whereas the cancer cells with definite positivity for p53 tended to stain either weakly or negatively for Rb and defi 8625241 Human
cyclin e retinoblastoma Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. 8649818 Human
cyclin e papillomas Cyclin E mRNA levels were increased 6.2-fold in 25 week (P < 0.01) and 6.9-fold in 45 week (P < 0.01) papillomas. 8761413 Human
cyclin e papillomas Immunohistochemical staining revealed exclusive nuclear staining of both cyclin D1 and cyclin E. Furthermore, there was a sequential increase in cyclin D1- and cyclin E-positive cells from normal epithelium, to preneoplastic lesions, to papillomas. 8761413 Human
cyclin e tumor These findings suggest that overexpression of cyclin D1 and cyclin E occur relatively early in rat esophageal tumorigenesis and participate in tumor progression in this model. 8761413 Human
cyclin e tumors Staining for cyclin E was present in four tumors and was present only in focal areas in two of the four. 8797586 Human
cyclin e breast and ovarian cancers Cyclin gene amplification and overexpression in breast and ovarian cancers: evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors. 8797862 Human
cyclin e ovarian tumors Cyclin gene amplification and overexpression in breast and ovarian cancers: evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors. 8797862 Human
cyclin e breast and ovarian cancer In the present study, we investigated the amplification, in human breast and ovarian cancer, of 5 cyclin genes; cyclin A, cyclin D1, cyclin D2, cyclin D3 and cyclin E. 8797862 Human
cyclin e breast tumors Cyclin D1 DNA amplification was much less frequent in ovarian than in breast tumors (3.3% vs. 12.6%), whereas cyclin E amplification and overexpression were observed in a significant number of cases (12.5% and 18.0% respectively). 8797862 Human
cyclin e tumor No clear correlation could be observed between amplification of the cyclin E gene and tumor type, stage or grade in ovarian cancer. 8797862 Human
cyclin e ovarian cancer No clear correlation could be observed between amplification of the cyclin E gene and tumor type, stage or grade in ovarian cancer. 8797862 Human
cyclin e human breast cancer In this study, we showed that mimosine can increase both p21 mRNA and protein levels, indirectly inhibit cyclin E-associated kinase activity without affecting the cyclin E protein level, block human breast cancer cells (21PT) in the late G1 phase of the c 8809407 Human
cyclin e adenocarcinomas Expression of cyclin D1 but not of cyclin E is an indicator of poor prognosis in small adenocarcinomas of the lung. 12469159 Human
cyclin e adenocarcinomas We investigated the significance of cyclin D1 and cyclin E expression in resected tumors on the survival of patients with small adenocarcinomas of the lung. 12469159 Human
cyclin e tumors We investigated the significance of cyclin D1 and cyclin E expression in resected tumors on the survival of patients with small adenocarcinomas of the lung. 12469159 Human
cyclin e tumors The resected tumors were subjected to immunostaining for cyclin D1 and cyclin E expression. 12469159 Human
cyclin e adenocarcinomas Increased expression of cyclin D1 but not of cyclin E is an indicator of poor prognosis in patients with small adenocarcinomas of the lung. 12469159 Human
cyclin e gastric cancer Cyclin E immunoexpression in gastric cancer does not correlate with clinicopathological parameters. 12493027 Human
cyclin e gastric cancer AIMS: To ascertain whether cyclin E immunoexpression relates to clinicopathological characteristics of gastric cancer and is of possible routine use. 12493027 Human
cyclin e gastric cancer CONCLUSIONS: We have not demonstrated any significant relationship between cyclin E immunopositivity and any of the usual clinicopathological parameters (especially lymph node involvement) and therefore cyclin E immunohistochemistry alone does not appear 12493027 Human
cyclin e1 cancers Compared with CP, cancers demonstrated: (i) increased expression of tumor related genes including S100A4, cyclin E1, and epidermal growth factor (EGF) receptor, and (ii) expression of matrix metalloproteinase 2, a pro-invasive factor for tumor cells, whic 15166955 Human
cyclin e breast cancer Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status. 8826852 Human
cyclin e tumours Cyclin E is a G1 cyclin which has been proposed to be one of the key regulators of the important G1/S transition, and could consequently be a potential deregulated molecule in tumours. 8826852 Human
cyclin e breast cancer Recently, it has been observed that cyclin E is overexpressed in a variety of malignancies including breast cancer and that several isoforms of the protein exists. 8826852 Human
cyclin e primary breast cancer In this study we have characterised the cyclin E expression in 114 tumour specimens from patients with primary breast cancer using Western blotting. 8826852 Human
cyclin e tumour In this study we have characterised the cyclin E expression in 114 tumour specimens from patients with primary breast cancer using Western blotting. 8826852 Human
cyclin e breast cancer Various expression of cyclin E was observed among tumours and a group of 27 patients out of 100 patients with stage I-III disease, identified as having tumours with high cyclin E levels, had a significantly increased risk of death and relapse from breast 8826852 Human
cyclin e tumours Various expression of cyclin E was observed among tumours and a group of 27 patients out of 100 patients with stage I-III disease, identified as having tumours with high cyclin E levels, had a significantly increased risk of death and relapse from breast 8826852 Human
cyclin e tumours There was also a strong association between cyclin E expression and oestrogen receptor status (P < 0.00001), and tumours with high cyclin E expression were in general oestrogen receptor negative, suggesting a potential role for cyclin E in mechanisms resp 8826852 Human
cyclin e tumour There was also a strong association between cyclin E expression and oestrogen receptor status (P < 0.00001), and tumours with high cyclin E expression were in general oestrogen receptor negative, suggesting a potential role for cyclin E in mechanisms resp 8826852 Human
cyclin e colon carcinoma To further investigate the role that cell cycle regulation may play during differentiation of intestinal epithelial cells, we examined the expression of p53, p21, cyclin D1, cyclin E, and E2F1 in the Caco-2 colon carcinoma cell line, which differentiates 8831553 Human
ccne human tumors Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. 8833152 Human
cyclin e human tumors Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. 8833152 Human
cyclin e adenocarcinomas Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein. 8865848 Human
cyclin e colorectal adenomas Expression of cyclin E in colorectal adenomas and adenocarcinomas: correlation with expression of Ki-67 antigen and p53 protein. 8865848 Human
cyclin e adenocarcinomas The expression of cyclin E in human colorectal adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in the colorectal carcinogenesis. 8865848 Human
cyclin e colorectal adenomas The expression of cyclin E in human colorectal adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in the colorectal carcinogenesis. 8865848 Human
cyclin e adenocarcinomas The expression of cyclin E was detected in 25% (91/358) of the adenomas and 56% (149/267) of the adenocarcinomas. 8865848 Human
cyclin e adenomas The expression of cyclin E was detected in 25% (91/358) of the adenomas and 56% (149/267) of the adenocarcinomas. 8865848 Human
cyclin e adenomas Among adenomas, a significant correlation was noticed between the expression of cyclin E and the grade of atypia. 8865848 Human
cyclin e adenocarcinomas The incidence of cyclin E expression was significantly higher in the adenocarcinomas without an adenoma component (62%; 104/169) than in those with this component (46%; 45/98) (P < 0.05). 8865848 Human
cyclin e carcinoma Furthermore, the incidence of the cyclin E expression was higher in stages 1 and 2 carcinoma than in stage 0 and stages 3 and 4 carcinoma. 8865848 Human
cyclin e tumors The expression of cyclin E was the most prominent in tumors invading the submucosa and muscularis propria. 8865848 Human
cyclin e tumor The expression of cyclin E was significantly correlated with the proliferative activity of the tumor cells measured by Ki-67 antigen expression (P < 0.01). 8865848 Human
cyclin e colorectal carcinomas Overexpression of cyclin E and subsequent deregulation of cell cycle may contribute to the development and early progression of the colorectal carcinomas. 8865848 Human
cyclin e breast cancer Treating breast cancer cells with 400 microM mimosine for 24 h inhibited cyclin E- and cyclin A-associated kinase activity by 85% or more, although immunoblots using anti-cyclin A, cyclin E, cdc2, and cdk2 antibodies showed that these key subunits were st 8940249 Human
cyclin e human tumors Since cyclin E is commonly overexpressed in a variety of human tumors, these findings may point to a link between the uncontrolled proliferation and the genomic instability typically seen in malignant tumors. 8957094 Human
cyclin e malignant tumors Since cyclin E is commonly overexpressed in a variety of human tumors, these findings may point to a link between the uncontrolled proliferation and the genomic instability typically seen in malignant tumors. 8957094 Human
cyclin e breast cancer Cyclin E, a redundant cyclin in breast cancer. 8986790 Human
cyclin e tumor Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecular weight isoforms of cyclin E, which together with cdk2 can form a kinase complex active throughout the cell cycle. 8986790 Human
cyclin e breast cancer In this study, we report that one of the substrates of this constitutively active cyclin E/cdk2 complex is retinoblastoma susceptibility gene product (pRb) in populations of breast cancer cells and tissues that also overexpress p16. 8986790 Human
cyclin e tumor In addition, the constitutively overexpressed cyclin E is also the predominant cyclin found in p107/E2F complexes throughout the tumor, but not the normal, cell cycle. 8986790 Human
cyclin e tumors These observations suggest that overexpression of cyclin E in tumor cells, which also overexpress p16, can bypass the cyclin D/cdk4-cdk6/p16/pRb feedback loop, providing yet another mechanism by which tumors can gain a growth advantage. 8986790 Human
cyclin e tumor These observations suggest that overexpression of cyclin E in tumor cells, which also overexpress p16, can bypass the cyclin D/cdk4-cdk6/p16/pRb feedback loop, providing yet another mechanism by which tumors can gain a growth advantage. 8986790 Human
cyclin e adenocarcinomas Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status. 9414392 Human
cyclin e gastric adenomas Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status. 9414392 Human
cyclin e adenocarcinomas The expression of cyclin E in human gastric adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in stomach carcinogenesis. 9414392 Human
cyclin e gastric adenomas The expression of cyclin E in human gastric adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in stomach carcinogenesis. 9414392 Human
cyclin e adenocarcinomas The expression of cyclin E was detected in 49% (90/182) of the adenomas and 59% (260/439) of the adenocarcinomas. 9414392 Human
cyclin e adenomas The expression of cyclin E was detected in 49% (90/182) of the adenomas and 59% (260/439) of the adenocarcinomas. 9414392 Human
cyclin e adenocarcinomas The incidence of strongly positive cases (overexpression of cyclin E) was significantly higher in the adenocarcinomas (29%; 128/439) than in the adenomas (4%; 8/182) (p < 0.01). 9414392 Human
cyclin e adenomas The incidence of strongly positive cases (overexpression of cyclin E) was significantly higher in the adenocarcinomas (29%; 128/439) than in the adenomas (4%; 8/182) (p < 0.01). 9414392 Human
cyclin e invasive carcinomas The incidence of the cyclin E expression showed a tendency to be higher in deeply invasive carcinomas and in the cases with lymph node metastasis, while the incidence did not differ among histological types. 9414392 Human
cyclin e lymph-node metastasis The incidence of the cyclin E expression showed a tendency to be higher in deeply invasive carcinomas and in the cases with lymph node metastasis, while the incidence did not differ among histological types. 9414392 Human
cyclin e tumor The expression of cyclin E was significantly correlated with the proliferative activity of the tumor cells measured by KI-67 antigen expression (p < 0.01). 9414392 Human
cyclin e gastric carcinomas These results suggest that overexpression of cyclin E and subsequent deregulation of the cell cycle may confer the development and progression of the gastric carcinomas. 9414392 Human
cyclin e1 hodgkins lymphoma High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1. 12533833 Human
ccne tumours In most of the individual tumours, over 75% of the HRS cells stained positive for CCNE, suggesting that CCNE is overexpressed in cHL. 12533833 Human
cyclin e non-small cell lung carcinoma Expression of cyclin A, cyclin E and cdk2 was examined immunohistochemically in 144 cases of primary non-small cell lung carcinoma to evaluate their prognostic value. 12533834 Human
cyclin e squamous cell carcinoma (scc) Cyclin E exhibited a characteristic staining pattern: in squamous cell carcinoma (SCC), differentiated cells without Ki-67 staining revealed cyclin E positivity with expression of cdk2. 12533834 Human
cyclin e adenocarcinoma Conversely, in adenocarcinoma (AC), proliferating cells revealed cyclin E positivity. 12533834 Human
cyclin e large-cell carcinoma Cases of large cell carcinoma showed heterogeneous cyclin E staining patterns, unlike those of SCC or AC. 12533834 Human
cyclin e gastric cancer Gene amplification of cyclin D is found preferentially in esophageal cancer, whereas gene amplification of cyclin E and c-met is frequently associated with gastric cancer. 7889467 Human
cyclin e esophageal cancer Gene amplification of cyclin D is found preferentially in esophageal cancer, whereas gene amplification of cyclin E and c-met is frequently associated with gastric cancer. 7889467 Human
cyclin e hyperplasia First, the level of normal cyclin E (p50) expression was positively correlated with the tumorigenic potentials of different hyperplasia lines. 7728962 Human
cyclin e tumor Second, several cyclin E isoforms (p48, p43, p35, p34, p32) were detected only in tumor tissues. 7728962 Human
cyclin e tumors High levels of cdk2 kinase activity are observed only in tumors and appear to be closely related to alterations in cyclin E protein expression. 7728962 Human
cyclin e myelodysplastic syndromes The prevalence and clinical relevance of p27 and cyclin E immunoreactivity in myelodysplastic syndromes. 12551833 Human
cyclin e breast cancer Cyclin E is a more powerful predictor of breast cancer outcome than proliferation. 12563321 Human
cyclin e colorectal carcinomas Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas. 7601562 Human
cyclin e colorectal carcinoma Gene amplification of cyclin E was detected in 5 of 53 (9.4%) primary colorectal carcinoma tissues. 7601562 Human
cyclin e tumors Interestingly, in 3 of 5 tumors showing cyclin E gene amplification, the CDK2 gene was amplified simultaneously with rearrangements. 7601562 Human
cyclin e colon carcinoma Out of 7 colon carcinoma cell lines, 2 showed gene amplification of cyclin E without gene amplification of CDK2. 7601562 Human
cyclin e tumour Threshold expression of cyclin E but not D type cyclins characterizes normal and tumour cells entering S phase. 7626688 Human
cyclin e chronic lymphocytic leukemias (cll) The expression of certain cell cycle regulatory proteins: cdk1, cdk2, cdk4, cyclin A, cyclin B, cyclin E, Bcl2 and PCNA was examined in peripheral blood lymphocytes (PBL) from 25 cases of chronic lymphocytic leukemias (CLL) in order to analyze a possible 7643628 Human
cyclin e tumour Abnormal expression pattern of cyclin E in tumour cells. 12569561 Human
cyclin e tumour The expression pattern of cyclin E during the cell cycle was studied in normal and tumour cells in culture and in tumour biopsies. 12569561 Human
cyclin e tumour In the tumour cell lines, cyclin E was not downregulated in early S-phase, as in normal cells. 12569561 Human
cyclin e tumour In about half of the analysed tumour cell lines, many cells stained positive for cyclin E even in the G(2)-phase. 12569561 Human
cyclin e tumours This abnormal expression over the cell cycle of cyclin E was also found in tumour biopsies from cervical, breast and prostatic carcinomas, even though it varied greatly between individual tumours. 12569561 Human
cyclin e prostatic carcinomas This abnormal expression over the cell cycle of cyclin E was also found in tumour biopsies from cervical, breast and prostatic carcinomas, even though it varied greatly between individual tumours. 12569561 Human
cyclin e tumour This abnormal expression over the cell cycle of cyclin E was also found in tumour biopsies from cervical, breast and prostatic carcinomas, even though it varied greatly between individual tumours. 12569561 Human
cyclin e tumours In some tumours, the expression pattern of cyclin E was similar to that of normal cells in culture, whereas in others high cyclin E levels could be seen in S-phase cells, as in the transformed cell lines. 12569561 Human
cyclin e cervical carcinoma A high percentage of cells expressing cyclin E during S- or G(2)-phase was found to be related to poor outcome (p < 0.025) in a small group of cervical carcinoma patients (n = 12). 12569561 Human
cyclin e breast tumors Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain. 12569370 Human
cyclin e breast tumors Abundant levels of the hyperactive low molecular weight (LMW) forms of cyclin E contribute to deregulation of Cdk2 in breast tumors, but the mechanism through which they arise is not fully understood. 12569370 Human
cyclin e breast tumors Here, we explored the hypothesis that post-translational processing by a protease generates the LMW forms of cyclin E in breast tumors. 12569370 Human
cyclin e tumor In ZR75 tumor cell lysates, calcium-induced cyclin E truncation into peptides corresponding in size with LMW forms of cyclin E in tumor tissues. 12569370 Human
cyclin e tumor Consistently, calcium+calpain caused truncation of cyclin E immunoprecipitated from tumor cells and tissues. 12569370 Human
cyclin e tumor Calcium also caused truncation of the calpain regulatory subunit in tumor cell lysates, indicating that elevated calpain activity accompanies cyclin E truncation. 12569370 Human
cyclin e breast tumors While elastase also caused cyclin E truncation, the cleavage pattern was distinct from that generated by calpain, suggesting discrete mechanisms in regulating the formation of LMW cyclin E in breast tumors. 12569370 Human
cyclin e breast tumors Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the calpain small subunit may contribute to increased calpain activity in breast tumors, causing abundant levels of LMW cyclin E. 12569370 Human
cyclin e breast cancer Deregulation of cyclin E in breast cancer. 7675453 Human
cyclin e breast cancer To understand the functional basis of these alterations we analyse here the regulation of cyclin E in breast cancer cells. 7675453 Human
cyclin e tumor We find that while cyclin E protein and its associated kinase activity in normal cells are cell cycle regulated, in tumor cells it remains in an active complex throughout the cell cycle. 7675453 Human
cyclin e tumor These variant forms of cyclin E were detected in several normal and tumor cell lines and tissue specimens. 7675453 Human
cyclin e tumor However, Western blot analysis indicated that only the multiple isoforms of cyclin E protein were expressed in tumor but not the normal tissue specimen, suggesting post transcriptional regulation of cyclin E. Lastly, in vitro analyses indicated that these 7675453 Human
cyclin e tumor Collectively these observations suggest the presence of more than one form of cyclin E mRNA in all cells, normal and tumor. 7675453 Human
cyclin e tumor Once translated in tumor cells, the protein products of these truncated forms could give rise to a constitutively active form of cyclin E containing complexes. 7675453 Human
cyclin e gastric cancer Amplification of the cyclin E gene is also observed in gastric cancer regardless of histologic type. 7676688 Human
cyclin e malignant tumor Overexpression of cyclin D1, but not cyclin E, rescued a signaling-defective src-homology 2 (SH2) domain mutant of BCR-ABL for transformation of cells in culture and malignant tumor formation in vivo. 7568169 Human
cyclin e human gastric carcinomas Frequent amplification of the cyclin E gene in human gastric carcinomas. 7559076 Human
cyclin e human gastric carcinoma We searched for genetic alterations of the cyclin D1 and cyclin E genes in 45 human gastric carcinoma tissues. 7559076 Human
cyclin e gastric cancer The cyclin E gene was amplified 3-10 fold in seven gastric cancer tissues (15.6%), of which six were advanced gastric cancers. 7559076 Human
cyclin e advanced gastric cancers The cyclin E gene was amplified 3-10 fold in seven gastric cancer tissues (15.6%), of which six were advanced gastric cancers. 7559076 Human
cyclin e lymph-node metastasis All of the cases with the cyclin E gene amplification displayed lymph node metastasis. 7559076 Human
cyclin e gastric cancer One of eight gastric cancer cell lines, MKN-7, shared the cyclin E gene amplification, and all of the gastric cancer cell lines expressed high levels of the cyclin E mRNA and protein even without gene amplification. 7559076 Human
cyclin e gastric carcinoma These results suggest that the gene amplification and overexpression of cyclin E play an important role in the abnormal growth and progression of gastric carcinoma. 7559076 Human
cyclin e tumors A moderate increase, 1.5- to 2-fold, in the level of cyclin E was observed in four tumors and three tumors displayed abnormal low molecular weight cyclin E-related proteins. 7554074 Human
cyclin e retinoblastoma A model of the G1 phase of the cell cycle incorporating cyclin E/cdk2 complex and retinoblastoma protein. 7566981 Human
cyclin e retinoblastoma A mathematical model of cyclin E, cdk2 and retinoblastoma protein control of the G1 phase of the human cell cycle is proposed. 7566981 Human
cyclin e osteosarcoma Furthermore, treatment with transforming growth factor beta for 48 h during the proliferation period renders the cells incompetent for differentiation and abrogates the postproliferative up-regulation of cyclins B and E. Density-induced growth inhibition 7585545 Human
cyclin e lymphoma Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells. 8673024 Human
cyclin e lymphoma The present study demonstrates that the genes of cyclin E, cdk2, cdk5 and the transcriptional factor E2F-1 are expressed during the prolactin (PRL)-induced G1/S transition in rat Nb2 pre-T lymphoma cells. 8673024 Human
cyclin e lymphoma These results suggest that cyclin E, cdk2, cdk5 and E2F-1 play the roles in the G1/S transition being expressed by a common cellular mechanism(s) in the PRL-stimulated pre-T lymphoma cells. 8673024 Human
cyclin-e human breast cancer Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer. 12894232 Human
cyclin-e breast cancer Recently, cyclin-E was reported to be the most prominent prognostic factor for breast cancer outcome described so far, even surpassing axillary nodal involvement. 12894232 Human
cyclin-e breast cancer Earlier studies on the prognostic value of cyclin-E in breast cancer, however, yielded heterogeneous results. 12894232 Human
cyclin-e breast cancers Therefore, we set out to confirm and extend these results by quantitative Taqman RT-PCR of cyclin-E levels in 277 resectable breast cancers. 12894232 Human
cyclin-e breast cancer In conclusion, cyclin-E is not a pure prognostic factor in breast cancer, but rather a predictor of failure of endocrine therapy. 12894232 Human
cyclin e tumors This study investigated the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary KRAS2-wild-type and the cyclin E overexpressing 14507635 Human
cyclin e pancreatic carcinoma This study investigated the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary KRAS2-wild-type and the cyclin E overexpressing 14507635 Human
cyclin e pancreatic adenocarcinomas Using pancreatic cancer microarrays and immunohistochemistry, we determined that 6% (4 of 46 and 5 of 100 in two independent panels) of pancreatic adenocarcinomas overexpress cyclin E. 14507635 Human
cyclin e pancreatic cancer Using pancreatic cancer microarrays and immunohistochemistry, we determined that 6% (4 of 46 and 5 of 100 in two independent panels) of pancreatic adenocarcinomas overexpress cyclin E. 14507635 Human
ccne1 pancreatic cancer We identified two potential mechanisms for this overexpression including the amplification/gain of CCNE1 gene copies in the Panc-1 and Su86.86 cell lines and a novel somatic homozygous mutation (H460R, in one of 11 pancreatic cancer xenografts having alle 14507635 Human
cyclin e pancreatic cancer We identified two potential mechanisms for this overexpression including the amplification/gain of CCNE1 gene copies in the Panc-1 and Su86.86 cell lines and a novel somatic homozygous mutation (H460R, in one of 11 pancreatic cancer xenografts having alle 14507635 Human
cyclin e mammary tumors Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. 12602925 Human
cyclin e mammary tumors Thus, we provide data that tamoxifen may differentially affect cell proliferation and apoptosis in mammary tumors and that the expression levels of cyclin D1 and cyclin E might also be considered potential intermediate biomarkers of response of mammary tu 12602925 Human
cyclin e tumors Nineteen (39.6%) biopsy specimens exhibited > or =10% neoplastic cells immunoreactive for p53, 23 (47.9%) for p21, 28 (58.3%) for HDM-2, 29 (60.4%) for cyclin E, and 16 (33.3%) for Ki-67; 23 (47.9%) tumors had > or =50% neoplastic cells immunoreactive for 12605365 Human
cyclin e leukemia Also, the level of WAF1/Cip1 protein expression was not correlated with overexpression of cyclin D1, cyclin E, proliferating cell nuclear antigen, cyclin-dependent kinase 4, or p53 in the leukemia cells. 9816079 Human
cyclin e breast cancer Cyclin E, a potential prognostic marker for breast cancer. 7903908 Human
cyclin e breast cancers Using surgical material obtained from patients with various malignancies, we show that breast cancers and other solid tumors, as well as malignant lymphocytes from patients with lymphatic leukemia, show severe quantitative and qualitative alterations in c 7903908 Human
cyclin e other solid tumors Using surgical material obtained from patients with various malignancies, we show that breast cancers and other solid tumors, as well as malignant lymphocytes from patients with lymphatic leukemia, show severe quantitative and qualitative alterations in c 7903908 Human
cyclin e lymphatic leukemia Using surgical material obtained from patients with various malignancies, we show that breast cancers and other solid tumors, as well as malignant lymphocytes from patients with lymphatic leukemia, show severe quantitative and qualitative alterations in c 7903908 Human
cyclin e breast cancer In addition, in breast cancer, the alterations in cyclin E expression become progressively worse with increasing stage and grade of the tumor, suggesting its potential use as a new prognostic marker. 7903908 Human
cyclin e tumor In addition, in breast cancer, the alterations in cyclin E expression become progressively worse with increasing stage and grade of the tumor, suggesting its potential use as a new prognostic marker. 7903908 Human
cyclin e carcinoma Using a monoclonal antibody developed to a mouse trophectodermal carcinoma stem cell line E6496D lysate, we have identified the gene that encodes murine cyclin E. 8003041 Mouse
cyclin e solid tumor Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. 8044772 Human
cyclin e colon carcinoma In the present study, multiparameter flow cytometry was used to correlate expression of cyclin B1 or cyclin E with cell cycle position (estimated by cellular DNA content) in normal human proliferating lymphocytes as well as in T-cell MOLT-4 leukemia; prom 8044772 Human
cyclin e transitional cell carcinoma In the present study, multiparameter flow cytometry was used to correlate expression of cyclin B1 or cyclin E with cell cycle position (estimated by cellular DNA content) in normal human proliferating lymphocytes as well as in T-cell MOLT-4 leukemia; prom 8044772 Human
cyclin e breast carcinoma In the present study, multiparameter flow cytometry was used to correlate expression of cyclin B1 or cyclin E with cell cycle position (estimated by cellular DNA content) in normal human proliferating lymphocytes as well as in T-cell MOLT-4 leukemia; prom 8044772 Human
cyclin e lymphoma In the present study, multiparameter flow cytometry was used to correlate expression of cyclin B1 or cyclin E with cell cycle position (estimated by cellular DNA content) in normal human proliferating lymphocytes as well as in T-cell MOLT-4 leukemia; prom 8044772 Human
cyclin e leukemia In the present study, multiparameter flow cytometry was used to correlate expression of cyclin B1 or cyclin E with cell cycle position (estimated by cellular DNA content) in normal human proliferating lymphocytes as well as in T-cell MOLT-4 leukemia; prom 8044772 Human
cyclin e tumour By univariate analysis, tumour size, histopathological grade, hormone receptor content, cyclin E, cyclin B, and the Ki-S5 (Ki-67) index significantly predicted disease-specific and metastasis-free survival. 12635132 Human
cyclin e breast cancer Cyclin E in breast cancer. 12637621 Human
cyclin e breast cancer Cyclin E in breast cancer. 12638586 Human
cyclin e breast cancer Cyclin E in breast cancer. 12638587 Human
cyclin e breast cancer Cyclin E in breast cancer. 12638588 Human
cyclin e malignant lymphomas High levels of cyclin E and low levels of p27(Kip1) expression have been associated with malignant lymphomas in humans; the level of p27(Kip1) is even considered of prognostic significance. 12642875 Human
cyclin e lymphoid malignancies Our findings demonstrate that a deregulation of control mechanisms at the G1/S transition by the combination of high cyclin E levels in the absence of p27(Kip1) is sufficient to predispose mice to develop lymphoid malignancies and further support a role o 12642875 Human
cyclin e tumor Our findings demonstrate that a deregulation of control mechanisms at the G1/S transition by the combination of high cyclin E levels in the absence of p27(Kip1) is sufficient to predispose mice to develop lymphoid malignancies and further support a role o 12642875 Mouse
cyclin e diffuse large b-cell lymphomas Expression of cyclin D3 and cyclin E and identification of distinct clusters of proliferation and apoptosis in diffuse large B-cell lymphomas. 12647795 Human
cyclin e diffuse large b-cell lymphomas In the present study 79 cases of de novo Diffuse Large B-cell Lymphomas (DLBCL) were studied in order: a) to analyse the expression of cyclin D3, cyclin E and cyclin D1 in relation to other proliferative features (expression of Ki67, cyclin A and cyclin B 12647795 Human
cyclin e carcinomas Both Cip1/p21 and Kip1/p27 and levels of these proteins complexed with CDK2 were significantly elevated in ER carcinomas (P < 0.01), and levels of cyclin E were reduced. 12649181 Human
cyclin e ovarian epithelial cancers Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study. 12649182 Human
cyclin e cancers Abnormalities in cyclin E expression have been related to survival in a variety of cancers. 12649182 Human
cyclin e human ovarian cancer This study evaluated the prognostic relevance of cyclin E in human ovarian cancer. 12649182 Human
cyclin e epithelial ovarian cancer Immunohistochemical expression of cyclin E was evaluated in 139 advanced, suboptimally debulked epithelial ovarian cancer specimens from patients treated on Gynecologic Oncology Group protocol 111. 12649182 Human
cyclin e ovarian cancer High cyclin E protein expression (> or =40% cyclin E positive tumor cells) was seen in 62 (45%) of the advanced, suboptimally debulked ovarian cancer patients. 12649182 Human
cyclin e tumor High cyclin E protein expression (> or =40% cyclin E positive tumor cells) was seen in 62 (45%) of the advanced, suboptimally debulked ovarian cancer patients. 12649182 Human
cyclin e advanced ovarian cancer High cyclin E expression was an independent poor prognostic factor for patients with advanced ovarian cancer, and it was associated with amplification of the cyclin E gene. 12649182 Human
cyclin e hydatidiform moles In the benign trophoblastic lesions (exaggerated placental site [EPS] and placental site nodule [PSN]) and in the trophoblast proliferations on the surface of hydropic villi of hydatidiform moles (HM), the percentage of cells expressing cyclin E was highe 12649670 Human
cyclin e exaggerated placental site In the benign trophoblastic lesions (exaggerated placental site [EPS] and placental site nodule [PSN]) and in the trophoblast proliferations on the surface of hydropic villi of hydatidiform moles (HM), the percentage of cells expressing cyclin E was highe 12649670 Human
cyclin e ovarian cancer Expression and prognostic value of the cell-cycle regulatory proteins, Rb, p16MTS1, p21WAF1, p27KIP1, cyclin E, and cyclin D2, in ovarian cancer. 12649672 Human
cyclin e ovarian cancer To investigate the role of cell-cycle regulatory proteins in ovarian cancer, we performed immunohistochemistry for the cell-cycle promoters cyclin E and cyclin D2 and the cell-cycle inhibitors, Rb, p16MTS1, p21WAF1, and p27 KIP1, in 93 ovarian carcinomas 12649672 Human
cyclin e ovarian carcinomas To investigate the role of cell-cycle regulatory proteins in ovarian cancer, we performed immunohistochemistry for the cell-cycle promoters cyclin E and cyclin D2 and the cell-cycle inhibitors, Rb, p16MTS1, p21WAF1, and p27 KIP1, in 93 ovarian carcinomas 12649672 Human
cyclin e carcinomas Strong Rb and moderate-high cyclin E immunoreactivity in carcinomas were weakly associated with high expression of the proliferation marker Ki67. 12649672 Human
cyclin e human gastric cancer Expressions of cyclin E, cyclin dependent kinase 2 and p57(KIP2) in human gastric cancer. 12667381 Human
cyclin e human gastric cancer OBJECTIVE: To investigate the expressions of cyclin E, cyclin dependent kinase 2 (CDK-2) and cyclin-dependent kinase inhibitor p57(KIP2) in human gastric cancer, and to evaluate the relationships between protein levels and clinicopathological parameters. 12667381 Human
cyclin e gastric carcinoma METHODS: Western blot was used to measure the expressions of cyclin E, CDK-2 and p57(KIP2) proteins in the surgically resected gastric carcinoma, adjacent normal mucosa and metastatic lymph nodes from 36 patients. 12667381 NA
cyclin e gastric cancer RESULTS: Cyclin E and CDK-2 protein levels were higher in gastric cancer tissues in comparison with normal tissues (P < 0.05). 12667381 Human
cyclin e tumor No statistically significant difference between cyclin E and CDK-2 expression was found when samples were stratified according to tumor size (P > 0.05). 12667381 Human
cyclin e gastric cancer CONCLUSION: Overexpressions of cyclin E, CDK-2 and downregulated expression of p57(KIP2) may play important roles in tumorigenesis and metastatic potential of gastric cancer. 12667381 Human
cyclin e breast cancer Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. 15126360 Human
cyclin e breast cancer The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. 15126360 Human
cyclin e breast cancer Lastly, tumors from breast cancer patients overexpressing the LMW forms of cyclin E are polyploid in nature and are resistant to endocrine therapy. 15126360 Human
cyclin e tumors Lastly, tumors from breast cancer patients overexpressing the LMW forms of cyclin E are polyploid in nature and are resistant to endocrine therapy. 15126360 Human
cyclin e breast cancer Collectively, the biochemical and functional differences between the full-length and the LMW isoforms of cyclin E provide a molecular mechanism for the poor clinical outcome observed in breast cancer patients harboring tumors expressing high levels of the 15126360 Human
cyclin e tumors Collectively, the biochemical and functional differences between the full-length and the LMW isoforms of cyclin E provide a molecular mechanism for the poor clinical outcome observed in breast cancer patients harboring tumors expressing high levels of the 15126360 Human
cyclin e tumors These properties of the LMW forms cyclin E suggest that they are not just surrogate markers of poor outcome but bona fide mediators of aggressive disease and potential therapeutic targets for patients whose tumors overexpress these forms. 15126360 Human
cyclin e breast tumor Breast tumor specimens obtained from these women were centrally reviewed for histologic characteristics and evaluated for expression of estrogen and progesterone receptors (ER/PR), c-ErbB-2, Ki-67, p53, cyclin E, cyclin D1, p27, p16, pRb, and p21 by immun 15197793 Human
cyclin e tumor After adjustment for disease stage and age at diagnosis, AA women also were found to have increased odds of having a higher-grade tumor, a higher mitotic index, marked tumor necrosis, ductal histology, loss of ER and PR, overexpression of cyclin E, p16, a 15197793 Human
cyclin e tumor necrosis After adjustment for disease stage and age at diagnosis, AA women also were found to have increased odds of having a higher-grade tumor, a higher mitotic index, marked tumor necrosis, ductal histology, loss of ER and PR, overexpression of cyclin E, p16, a 15197793 Human
cyclin e tumor Ebp1 binds the tumor suppressor retinoblastoma protein (Rb) both in vivo and in vitro, and Rb and Ebp1 cooperate to inhibit the transcription of the E2F1-regulated cyclin E promoter. 12682367 Human
cyclin e tumor Cyclin D2 was found to be amplified in one tumor and cyclin E in another. 8481900 Human
cyclin e retinoblastoma We have found up-regulated levels of the cyclin-dependent kinase 2 (cdk2) protein in HDF expressing 143(ala) mutant p53 as compared to senescent controls, together with an increase in p21-free cdk2 which, in conjunction with cyclin E, is able to form an a 12706118 Human
cyclin e human hepatoma Recently, we have documented the accumulation of a cyclin-dependent kinase inhibitor, p27(Kip1), as well as an unexpected accumulation in cyclin E in G1-arrested human hepatoma cells treated with the PPARgamma ligand troglitazone. 12717389 Human
ccne1 human gastric cancer MYC, ERBB2, MET, FGFR2, CCNE1, MYCN, WNT2, CD44, MDM2, NCOA3, IQGAP1 and STK6 loci are amplified in human gastric cancer. 12739007 Human
cyclin e endometrial adenocarcinoma Immunohistochemical expression of cyclin E in endometrial adenocarcinoma (endometrioid type) and its clinicopathological significance. 12684894 Human
cyclin e endometrial adenocarcinoma This study aimed to investigate the correlation of cyclin E expression with tumorigenesis of the endometrium, proliferative activity, and clinicopathological features of endometrial adenocarcinoma. 12684894 Human
cyclin e endometrial hyperplasias METHODS: Immunohistochemical staining for cyclin E in addition to cyclin-dependent kinase 2 (cdk2), Ki67, p27, and p53 was performed by the labeled streptavidin-biotin method on formalin-fixed, paraffin-embedded tissues of normal endometria (20 cases), en 12684894 NA
cyclin e endometrial adenocarcinomas METHODS: Immunohistochemical staining for cyclin E in addition to cyclin-dependent kinase 2 (cdk2), Ki67, p27, and p53 was performed by the labeled streptavidin-biotin method on formalin-fixed, paraffin-embedded tissues of normal endometria (20 cases), en 12684894 NA
cyclin e endometrial hyperplasia Both proliferative and secretory endometria, and endometrial hyperplasia regardless of type were negligible for cyclin E expression. 12684894 Human
cyclin e endometrial adenocarcinomas LIs of cyclin E in well-differentiated, moderately differentiated, and poorly differentiated endometrial adenocarcinomas were 31.5+/-33.3%, 37.8+/-31.9%, and 51.1+/-30.8%, respectively. 12684894 Human
cyclin e carcinoma The LI of cyclin E in carcinoma was positively correlated with that of cdk2, Ki67, and p53 but not with p27. 12684894 Human
cyclin e endometrial hyperplasia The cyclin E expression was correlated with myometrial invasion and lymph-vascular space involvement, but not with FIGO stage, lymph node metastasis, coexisting endometrial hyperplasia, estrogen receptor, progesterone receptor, and menopause. 12684894 Human
cyclin e lymph-node metastasis The cyclin E expression was correlated with myometrial invasion and lymph-vascular space involvement, but not with FIGO stage, lymph node metastasis, coexisting endometrial hyperplasia, estrogen receptor, progesterone receptor, and menopause. 12684894 Human
cyclin e endometrial adenocarcinoma CONCLUSION: Cyclin E as a complex with cdk2 is associated with carcinogenesis and disease progression in endometrial adenocarcinoma, and might be a prognostic indicator of endometrial adenocarcinoma. 12684894 Human
cyclin e breast carcinomas A population-based series of 122 patients with pregnancy-associated breast carcinomas was histologically revised and the relationship between hormone receptors, c-erbB-2, BRCA1, p27, cyclin E, and cyclin D1 was studied. 12754622 Human
cyclin e tumors In conclusion, pregnancy-associated breast carcinomas are aggressive tumors, with low expression of hormone receptors, BRCA1, p27, and cyclin E and D1, and high expression of c-erbB-2. 12754622 Human
cyclin e breast carcinomas In conclusion, pregnancy-associated breast carcinomas are aggressive tumors, with low expression of hormone receptors, BRCA1, p27, and cyclin E and D1, and high expression of c-erbB-2. 12754622 Human
cyclin e liver cancer In contrast, degradation of the AhR in HepG2 liver cancer cells resulted in decreased G0/G1 --> S phase progression, and this was accompanied by decreased expression of cyclin D1, cyclin E, cyclin-dependent kinase 2 (cdk2), and cdk4. 12761348 Human
cyclin e lymphoma The effect of transforming growth factor-beta (TGF-beta) and serum stimulation on p27Kip1 expression and cyclin E/cdk2 activity was investigated in four lymphoma cell lines, Jurkat, CEM-6, OCI-Ly1 and Nalm-6. 12780788 Human
cyclin e carcinomas Positive staining for cyclin D1, cyclin E, cyclin A, cyclin B1, cdk2, cdk4, cdc2, p53, p21, and p27 was observed in 63%, 66%, 31%, 32%, 51%, 77%, 71%, 43%, 35%, and 60% of the 82 carcinomas, respectively. 12792921 Human
cyclin e tumour Southern blot analysis of six tumour specimens and three tumour cell lines, with five probes mapped to the 19q12-13.2 region, suggested cyclin E to be one of the candidate target genes in the 19q region for gastric cancer tumorigenesis. 12799636 Human
cyclin e gastric cancer Southern blot analysis of six tumour specimens and three tumour cell lines, with five probes mapped to the 19q12-13.2 region, suggested cyclin E to be one of the candidate target genes in the 19q region for gastric cancer tumorigenesis. 12799636 Human
cyclin e tumours Cyclin E protein overexpression was verified in tumours with amplification on chromosome 19. 12799636 Human
cyclin e gastric cancer Further studies are required to investigate the biological and clinical significance of 19q amplicon and cyclin E upregulation in gastric cancer of young patients. 12799636 Human
cyclin e cancers Increased expression of cyclin E is a frequent event in human malignancies and has been associated with poor prognosis in various cancers. 12799643 Human
cyclin e tumour These results suggest that cyclin E overexpression might reduce tumour cells sensitivity to doxorubicin by affecting the expression of MnSOD and that determination of cyclin E expression levels might help to select patients to be treated with an anthracyc 12799643 Human
cyclin e endometrial cancer Cyclin E dysregulation and chromosomal instability in endometrial cancer. 15048079 Human
cyclin e endometrial cancer The gene encoding the F-box protein hCdc4, a key component of the molecular machinery that targets cyclin E for degradation, is frequently mutated in endometrial cancer, leading to deregulation of cyclin E expression. 15048079 Human
cyclin e endometrial cancer Here we show that hCDC4 gene mutation and hyperphosphorylation of cyclin E, a parameter that usually correlates with hCDC4 mutation, have a strong statistically significant association with polypoidy and aneuploidy in endometrial cancer. 15048079 Human
cyclin e tumors On the contrary, elevated expression of cyclin E by itself was not significantly correlated with polyploidy or aneuploidy when tumors of similar grade are evaluated. 15048079 Human
ccne1 fallopian-tube carcinoma Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma. 12833150 Human
cyclin e hepatocellular carcinoma (hcc) Here, we show that overexpression of the oncogene cyclin E can be suppressed by up to 90% in hepatocellular carcinoma (HCC) cell lines by siRNA targeted on the coding region of cyclin E. 12839946 Human
cyclin e tumors Analysis of cell cycle parameters in tumors treated with RU indicated that RU-loaded PEG-PLA NS injected at 4.3 mg/kg/week in MCF-7 tumors decreased cyclin D(1) and cyclin E simultaneously, and increased p27. 12845687 Human
cyclin e tumours Cyclin E overexpression and amplification in human tumours. 12845634 Human
cyclin e tumour Cyclin E amplification and overexpression have recently been described in several tumour types. 12845634 Human
cyclin e tumour However, many tumour entities have never been examined for cyclin E alterations. 12845634 Human
cyclin e squamous-cell carcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e ovarian cancer Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e gall bladder adenocarcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e adenocarcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e endometrial carcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e malignant fibrous histiocytoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e urinary bladder cancer Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e gastric adenocarcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e breast cancer Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e colonic adenocarcinoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e rhabdomyosarcoma Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e tumour Cyclin E gene amplification was observed in 15 different tumour types and subtypes, ie rhabdomyosarcoma, urinary bladder cancer (three subtypes), ovarian cancer (two subtypes), malignant fibrous histiocytoma, adenocarcinoma of the small intestine, medulla 12845634 Human
cyclin e tumour Cyclin E protein accumulation was found in 48 different tumour types. 12845634 Human
cyclin e tumours The use of TMA technology has enabled us to expand considerably our knowledge of cyclin E alterations in human tumours. 12845634 Human
cyclin e tumour The occurrence of amplification and overexpression in many different tumour types suggests that cyclin E plays an important role in tumour biology. 12845634 Human
cyclin e carcinomas Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated. 12807724 Human
cyclin e tumors Cyclin E and B1 and kinases were almost only expressed in grade III tumors. 12873740 Human
cyclin e node-negative breast cancer Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer. 12884237 Human
cyclin e breast cancer This study was performed to analyze the impact of cyclin E expression to the outcome of breast cancer together with cyclin D1 and p27Kip1. 12884237 Human
cyclin e breast carcinomas RESULTS: Cyclin E expression was observed in 48 (27.4%) of 175 breast carcinomas. 12884237 Human
cyclin e tumors Cyclin E expression was significantly increased in young age patients and poorly differentiate tumors. 12884237 Human
cyclin e tumors Expression of cyclin E was significantly increased in cyclin D1 expressing tumors (P = 0.034). p27Kip1 expression was preserved above the 50% level in 87 tumors (49.7%) and was inversely correlated with cyclin E expression (P = 0.042). 12884237 Human
cyclin e neoplasia In vivo cyclin E expression as a marker for early cervical neoplasia. 9872657 Human
cyclin e neoplasia Regulators of the cell cycle such as cyclin E play an important part in neoplasia. 10224221 Human
cyclin e neoplasia Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHODS: We therefore investigated the expressio 10870044 Human
cyclin e neoplasia A feasibility study. OBJECTIVE: To investigate cyclin E expression as a possible marker for early cervical neoplasia using ThinPrep gynecologic specimens from premenopausal women. 10833982 Human
cyclin e neoplasia Cyclin E expression and early cervical neoplasia in ThinPrep specimens. 10833982 Human
cyclin e neoplasia Using formalin-fixed, paraffin-embedded cervical tissues, we investigated the expression of cyclin E and p27(KIP1) by immunohistochemistry, and human papillomavirus (HPV) types 16 and 18 by nested polymerase chain reaction (PCR) in 22 control cases, 23 ca 10779628 Human
cyclin e neoplasia Prior studies of Ki-67, cyclin E, and p16 expression have suggested that these biomarkers may be preferentially expressed in cervical neoplasia. 11420459 Human
cyclin e neoplasia Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. 11420459 Human
cyclin e neoplasia This review surveys recent advances in this field, summarizing the advantages and limitations of several candidate biomarkers, including PCNA, Ki-67, cyclin E, p16ink4, MN antigen, carcinoembryonic antigen (CEA), and telomerase in the recognition of prein 11236957 Human
cyclin e neoplasias Levels of cyclin D1, cyclin E and retinoblastoma (pRb) proteins were higher in these renal neoplasias than in adjacent uninvolved renal tissue and kidneys from untreated, age-matched animals. 11133805 Human
cyclin e actinic keratosis In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e bowens disease In order to evaluate the role of cyclin E in human keratinocyte carcinogenesis, we analysed the expression of cyclin E by immunohistochemistry in normal skin, seborrheic keratosis (SK), keratoacanthoma (KA), actinic keratosis (AK), Bowen's disease (B 9194584 Human
cyclin e small bowel adenomas The levels of cyclin D1, cyclin E, p16, p21, p27, and p53 proteins were determined by immunohistochemistry in samples of normal small bowel (n = 16), small bowel adenomas (n = 20), and small bowel adenocarcinomas (n = 24). 10613343 Human
cyclin e dcis Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of beta-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes. 9504854 Human
cyclin e dcis We therefore characterised the cell cycle regulators cyclin E, cyclin D1, p27 and p16 in a material of DCIS cases arranged in a tissue microarray. 14612904 Human
cyclin e dcis As also observed in invasive breast cancer, there was a trend indicating that DCIS cases with high cyclin D1 were cyclin E low and oestrogen receptor-positive, whereas cyclin E high DCIS cases were cyclin D1 low and oestrogen receptor-negative. 14612904 Human
cyclin e dcis A statistically significantly higher expression of cyclin E oncogene and MTS1 tumor suppressor gene was seen in type III DCIS than in the other types, while no significant differences in the mRNA expression patterns of the other genes were observed. 9504854 Human
cyclin e dcis Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. 10066069 Human
cyclin e ductal carcinoma in situ Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. 10066069 Human
cyclin e ca METHODS: Expression of the proliferation-associated molecule cyclin E was immunohistochemically determined in metaplastic specialized epithelium (SE; n = 24), low grade dysplasia (LGD; n = 21), high grade dysplasia (HGD; n = 17), and invasive adenocarcino 10594854 NA
cyclin e gestational trophoblastic diseases METHODS: Using formalin fixed, paraffin embedded trophoblastic tissues, the authors investigated the expression of cyclin E by immunohistochemistry in placentas with hydropic change and gestational trophoblastic diseases. 10931468 NA
cyclin e nsclc In this study, we examined the mechanism by which t-RA blocks cell cycle progression in HBE cells and the possibility that this signaling event is blocked in non-small cell lung cancer (NSCLC) cells that are refractory to the growth inhibitory effects of 10447003 NA
cyclin e transitional cell carcinoma of the bladder In this study we investigated the expression of two key cell cycle regulators, p27(Kip1) and cyclin E, in the progression of transitional cell carcinoma of the bladder. 10514396 NA
cyclin e transitional cell carcinoma of the bladder We studied the relationship between protein levels of p27, cyclin E and Ki-67 and clinicopathological features of 145 consecutive Japanese patients with transitional cell carcinoma of the bladder using immunohistochemical staining. 11336477 NA
cyclin e malignancy OBJECTIVE: The aim of this study was to further evaluate whether the expression of p27(kip1), cyclin E, and cdk2 is related to the malignancy of ovarian tumors and whether their expressions, alone or in combination, are associated with prognosis in epithe 11585414 NA
cyclin e choriocarcinomas In this study we investigated the immunostaining patterns of G(1) restriction point and G(1)-S regulatory proteins E2F-1, Cdk2, cyclin E, p27(kip1), and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial mo 11598175 NA
cyclin e rb This study suggests that a modest overexpression of cyclin E abrogates the tamoxifen mediated growth arrest through modification of the RB/E2F pathway. 12096339 NA
cyclin e ampullary carcinoma METHODOLOGY: Using immunohistochemistry, we investigated the expression of p21WAF1/CIP1, p27Kip1, p16INK4, cyclin D1, cyclin E, pRb and p53 in 14 resected specimens of ampullary carcinoma and defined the proliferative activity of each tumor by quantifying 12239913 NA
cyclin e hcc METHODS: Expression of p27, cyclin E and cyclin A in 45 HCC specimens and 30 adjacent noncancerous lesions obtained from 45 patients during surgery was examined by immunohistochemical SABC assay. 14606074 NA

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