IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CDK9 Ensembl ENSG00000136807 Chromosome 9 Start 129587898 End 129592177
Description Cell division protein kinase 9 (EC 2.7.11.22)(EC 2.7.11.23)(Cyclin-dependent kinase 9)(Serine/threonine-protein kinase PITALRE)(Cell division cycle 2-like protein kinase 4)(C-2K) [Source:UniProtKB/Swiss-Prot;Acc:P50750]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1780
     Entrez Gene : 1025
     UCSC : uc004bse.2
     GeneCards : 1780
     RefSeq : NM_001261
     CCDS : CCDS6879.1
     Uniprot : P50750
     Interpro : P50750
     OMIM : 603251
     GeneTests : CDK9
     CGAP : CDK9
     PMID : 8170997

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.44 225 1 0.51 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16814 AD c.967G>A p.D323N Substitution - Missense Heterozygous 9:129591491-12959149118948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  387_at  -0.25  1.03e-3  3.23e-3  -0.34  3.28e-4  1.15e-3
 HG_U133A  203198_at  0.02  7.27e-1  7.65e-1  1.28  2.22e-27  3.60e-27
 HG_U133_Plus2  203198_at  0.38  1.12e-3  2.87e-3  0.83  2.12e-10  9.79e-10
 HG_U133_Plus2  228901_at  -0.11  5.30e-1  6.15e-1  0.38  8.06e-2  1.11e-1
 HG_U133_Plus2  236023_at  0.04  7.56e-1  8.12e-1  0.28  6.32e-2  8.87e-2
 Stanford  15912  0.18  2.92e-1  4.94e-1  0.05  8.25e-1  9.20e-1
 Stanford  22161  -0.45  5.08e-2  1.57e-1  -0.26  4.67e-1  6.89e-1
 Agilent_HS_21.6K  14407  0.07  3.54e-1  5.42e-1  0.07  2.99e-1  4.56e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203198_at  0.18  5.93e-1  9.51e-1  -0.22  3.13e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 387_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203198_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203198_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228901_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 236023_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15912    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22161    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14407    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cdk9 tumor Flavopiridol exerts multiple effects in tumor cells, including inhibition of multiple CDKs, transcriptional inhibition secondary to disruption of P-TEFb (CDK9/cyclin T), induction of apoptosis, and antiangiogenesis. 14751090 Human
cdk9 cancer CDK9: from basal transcription to cancer and AIDS. 12432243 Human
cdk9 cancer This data suggests the involvement of Cdk9 in several physiological processes in the cell, the deregulation of which may be related to the genesis of transforming events, that may in turn lead to the onset of cancer. 12432243 Human
pitalre cancer Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. 7882308 Human
pitalre human tumors Here we report the chromosomal mapping of two cdks, cdk3 and cdk6, two putative cdks, PISSLRE and PITALRE, and one cyclin-dependent kinase inhibitor, p27, to chromosomal regions which may be altered in human tumors and examine their possible involvement i 7882308 Human
pitalre other tumors In particular, two of the kinases, cdk3 and PISSLRE and PITALRE, the cdc2-related kinases recently cloned by us, map to regions previously shown to exhibit loss of heterozygosity in breast and other tumors. 7882308 Human
cdk9 anaplastic large-cell lymphomas CDK9 and CYCLIN T1 were highly expressed in lymphomas derived from precursor B and T cells, from germinal centre cells, such as follicular lymphomas, and from activated T cells (ie anaplastic large cell lymphomas). 15258998 Human
cdk9 follicular lymphomas CDK9 and CYCLIN T1 were highly expressed in lymphomas derived from precursor B and T cells, from germinal centre cells, such as follicular lymphomas, and from activated T cells (ie anaplastic large cell lymphomas). 15258998 Human
cdk9 lymphomas CDK9 and CYCLIN T1 were highly expressed in lymphomas derived from precursor B and T cells, from germinal centre cells, such as follicular lymphomas, and from activated T cells (ie anaplastic large cell lymphomas). 15258998 Human
cdk9 marginal-zone lymphomas No expression of CDK9 or CYCLIN T1 was detected in mantle cell and marginal zone lymphomas. 15258998 Human
cdk9 follicular lymphoma However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin's lymphomas, Burkitt's lymphomas, 15258998 Human
cdk9 anaplastic large-cell lymphoma However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin's lymphomas, Burkitt's lymphomas, 15258998 Human
cdk9 diffuse large b-cell lymphomas However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin's lymphomas, Burkitt's lymphomas, 15258998 Human
cdk9 classical hodgkin's lymphomas However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin's lymphomas, Burkitt's lymphomas, 15258998 Human
cdk9 burkitt's lymphomas However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin's lymphomas, Burkitt's lymphomas, 15258998 Human
cdk9 lung adenocarcinoma This study investigated roles of CDK9 in TNF-alpha-stimulated MMP-9 expression in human lung adenocarcinoma cells. 15528190 Human
cdk9 tumor Disruption of TNF-alpha signaling using CDK9 inhibitors could serve as a potential therapeutic strategy against tumor invasion and metastasis. 15528190 Human
cdk9 metastasis Disruption of TNF-alpha signaling using CDK9 inhibitors could serve as a potential therapeutic strategy against tumor invasion and metastasis. 15528190 Human
cdk9 tumor It has greatest activity against CDK2/cyclin E, CDK7/cyclin H, and CDK9/cyclin T. Seliciclib induces apoptosis from all phases of the cell cycle in tumor cell lines, reduces tumor growth in xenografts in nude mice and is currently in phase II clinical tri 15958589 Human
cyclin-dependent kinase 9 lung adenocarcinoma Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells. 15528190 Human

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