IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CDKN3 Ensembl ENSG00000100526 Chromosome 14 Start 53933476 End 53956682
Description Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48)(EC 3.1.3.16)(CDK2-associated dual-specificity phosphatase)(Kinase-associated phosphatase)(Cyclin-dependent kinase-interacting protein 2)(Cyclin-dependent kinase interactor 1) [Source:UniProtKB/Swiss-Prot;Acc:Q16667]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1791
     Entrez Gene : 1033
     UCSC : uc001xap.2
     GeneCards : 1791
     RefSeq : NM_001130851
     CCDS : CCDS9716.1
     Uniprot : Q9C046
     Interpro : Q9C046
     OMIM : 123832
     GeneTests : CDKN3
     CGAP : CDKN3
     PMID : 8242750

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1599_at  2.31  1.50e-10  2.18e-9  3.94  1.40e-15  5.17e-14
 HG_U133A  209714_s_at  1.25  2.98e-34  6.06e-33  -0.14  1.08e-1  1.13e-1
 HG_U133_Plus2  1555758_a_at  1.92  2.53e-19  5.56e-18  2.73  7.34e-36  7.11e-34
 HG_U133_Plus2  209714_s_at  1.81  5.11e-30  3.56e-28  2.58  2.95e-42  8.75e-40
 Stanford  8388  1.77  4.00e-4  8.03e-3  2.77  1.01e-7  2.02e-5
 Agilent_HS_21.6K  7397  0.34  4.34e-5  6.00e-4  0.60  2.80e-9  1.02e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209714_s_at  0.10  6.92e-1  9.67e-1  0.08  5.80e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1599_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209714_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1555758_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209714_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8388    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7397    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
kap prostate cancer Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. 10669749 Human
kinase-associated phosphatase prostate cancer Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. 10669749 Human
kap prostate cancer We have identified the KAP gene as an overexpressed gene in breast and prostate cancer by using a phosphatase domain-specific differential-display PCR strategy. 10669749 Human
kap tumor In normal cells, KAP is primarily found in the perinuclear region, but in tumor cells, a significant portion of KAP is found in the cytoplasm. 10669749 Human
kap prostate cancer These findings suggest that therapeutic intervention might be aimed at repression of KAP gene overexpression in human breast and prostate cancer. 10669749 Human
kap hepatocellular carcinoma (hcc) To investigate whether mutations of this enzyme occur in hepatocellular carcinoma (HCC), KAP mRNA was analyzed by reverse transcription-PCR (RT-PCR), followed by cloning and sequencing. 10987270 Human
cyclin-dependent kinase inhibitor 3 human neuroblastoma Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. 15147518 Human
cdkn3 neuroblastoma We found that in choline-deficient IMR-32 neuroblastoma cells, the promoter of the cyclin-dependent kinase inhibitor 3 gene (CDKN3) was hypomethylated. 15147518 Human
cyclin-dependent kinase inhibitor 3 neuroblastoma We found that in choline-deficient IMR-32 neuroblastoma cells, the promoter of the cyclin-dependent kinase inhibitor 3 gene (CDKN3) was hypomethylated. 15147518 Human
kap hepatocellular carcinoma Several aberrant KAP transcripts with characteristic deletion regions have been identified in hepatocellular carcinoma tissues. 12745075 Human
kap hepatoblastoma In this report, we demonstrated that multiple aberrant KAP transcripts were also present in a hepatoblastoma cell line (HepG2), albeit harboring a totally different set of deletions. 12745075 Human
kap hcc Eight of 14 biopsy tissues obtained from advanced HCC, 6 of 13 surgically removed HCC tissues, and 2 of the adjacent noncancerous tissues contained aberrant KAP transcripts. 10987270 Human
the kap gene prostate cancer We have identified the KAP gene as an overexpressed gene in breast and prostate cancer by using a phosphatase domain-specific differential-display PCR strategy. 10669749 Human
kap-1 myeloid leukaemia Association of endogenous Fes and KAP-1 was also observed in HL-60 myeloid leukaemia cells. 16792528 Human
kap ca Our results show that alpha KAP is largely localized at the free SR and thus near the Ca(2+) pump, a protein that can be modulated by CaM kinase II phosphorylation. 12470297 Human
kap ca Our results show that alpha KAP is largely localized at the free SR and thus near the Ca(2+) pump, a protein that can be modulated by CaM kinase II phosphorylation. 12470297 Human
kap neuroblastoma We also demonstrated in cultured neuroblastoma cells that KAP is not only expressed in dividing cells, but also in the neurites of differentiated cells. 16257389 Human
kap1 cancer KAP1 may serve as a therapeutic target against cancer in combination with actinomycin D. 17056014 Human
kap hepatocarcinogenesis These data suggest a possible role of KAP mutations in multiple-step hepatocarcinogenesis. 10987270 Human
kap glioblastoma Aberrant Splicing of Cyclin-Dependent Kinase-Associated Protein Phosphatase KAP Increases Proliferation and Migration in Glioblastoma. 17210692 Human
kap malignant astrocytomas Paradoxically, we find increased KAP mRNA expression in malignant astrocytomas, which correlates with increasing histologic grade and decreased patient survival. 17210692 Human
kap malignant astrocytomas We have resolved this apparent paradox with the discovery of aberrant KAP splicing in malignant astrocytomas that leads to increased expression of KAP-related transcripts but decreased KAP protein expression. 17210692 Human
kap gliomas Thus, KAP regulates both cdc2-dependent migration and Cdk2-dependent proliferation, and its loss due to aberrant splicing increases malignancy in human gliomas. 17210692 Human
kap malignancy Thus, KAP regulates both cdc2-dependent migration and Cdk2-dependent proliferation, and its loss due to aberrant splicing increases malignancy in human gliomas. 17210692 Human

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