IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CENPF Ensembl ENSG00000117724 Chromosome 1 Start 212843155 End 212904535
Description centromere protein F [Source:RefSeq peptide;Acc:NP_057427]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1857
     Entrez Gene : 1063
     UCSC : uc001hkm.2
     GeneCards : 1857
     RefSeq : NM_016343
     CCDS : CCDS31023.1
     Uniprot : P49454
     Interpro : P49454
     OMIM : 600236
     GeneTests : CENPF
     CGAP : CENPF
     PMID : 7904902

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37302_at  1.73  3.86e-14  1.06e-12  2.58  2.17e-10  2.73e-9
 HG_U133A  207828_s_at  1.76  4.86e-45  1.86e-43  -1.37  2.28e-26  3.63e-26
 HG_U133A  209172_s_at  1.05  5.79e-23  5.62e-22  4.79  2.13e-128  3.30e-127
 HG_U133_Plus2  207828_s_at  2.01  1.48e-35  1.85e-33  2.88  1.74e-41  4.48e-39
 HG_U133_Plus2  209172_s_at  1.41  2.91e-24  1.07e-22  2.18  2.08e-34  1.66e-32
 Stanford  8584  2.44  3.85e-7  6.99e-5  3.15  8.77e-11  4.24e-7
 Agilent_HS_21.6K  17336  0.71  5.18e-7  1.39e-5  1.01  5.97e-16  1.79e-13

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207828_s_at  -0.60  1.69e-1  8.15e-1  0.38  1.31e-1  1.00e+0
 HG_U133A  209172_s_at  -0.17  4.92e-1  9.26e-1  0.22  2.38e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37302_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207828_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209172_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207828_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209172_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8584    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17336    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mitosin tumors Nuclear grade, mitotic activity, and biomarker profile (Her2-neu and mitosin expression patterns) in pretreatment tumors were correlated with the postchemotherapy pathologic response. 12115341 Human
mitosin breast carcinoma CONCLUSIONS: The current results indicate that tumor nuclear grade and tumor proliferative activity (mitotic activity and mitosin immunostaining) of pretreatment tumors in patients with breast carcinoma may serve as important indicators for the pathologic 12115341 Human
mitosin tumors CONCLUSIONS: The current results indicate that tumor nuclear grade and tumor proliferative activity (mitotic activity and mitosin immunostaining) of pretreatment tumors in patients with breast carcinoma may serve as important indicators for the pathologic 12115341 Human
mitosin tumor CONCLUSIONS: The current results indicate that tumor nuclear grade and tumor proliferative activity (mitotic activity and mitosin immunostaining) of pretreatment tumors in patients with breast carcinoma may serve as important indicators for the pathologic 12115341 Human
mitosin diffuse astrocytoma Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival. 11556747 Human
cenpf esophageal squamous-cell carcinoma Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon. 11092977 Human
mitosin cancer Although autoantibodies against centromere protein-F, which is very similar to mitosin, have been reported in patients with cancer, this is the first report of autoantibodies against mitosin in a patient with cGVHD. 9156273 Human
mitosin node-negative breast cancer Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer. 9407959 Human
mitosin breast cancers Using a new monoclonal antibody (14C10), this pilot study evaluated mitosin expression by IHC in a series of 386 node-negative, formalin-fixed, archival breast cancers and correlated the results with several prognostic factors and clinical outcome (median 9407959 Human
mitosin node-negative breast cancer These preliminary results suggest that mitosin as assessed by IHC may be superior to SPF as a prognostic factor in node-negative breast cancer, but additional studies are necessary to validate these promising findings. 9407959 Human
mitosin intracranial meningiomas Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas. 12507285 Human
mitosin atypical meningiomas The expression of mitosin, a novel proliferation-associated molecule was evaluated immunohistochemically in a consecutive series of 47 patients with primary intracranial benign and atypical meningiomas. 12507285 Human
mitosin atypical meningiomas We conclude that mitosin immunohistochemical expression, although failing to discriminate between benign and atypical meningiomas, may be of use as a novel cell proliferation marker and as a predictor of tumor recurrence. 12507285 Human
mitosin tumor We conclude that mitosin immunohistochemical expression, although failing to discriminate between benign and atypical meningiomas, may be of use as a novel cell proliferation marker and as a predictor of tumor recurrence. 12507285 Human
ah antigen melanoma We conclude that vaccines prepared from irradiated allogeneic melanoma cells expressing AH antigen, a demonstrably immunogenic differentiation antigen of the melanocyte lineage, are not effective in inducing AH antibody. 6852975 Human
ah antigen tumor Neither BD nor AH antigen was found on normal cells from autologous, allogeneic, or xenogeneic sources or on any nonmelanoma tumor cell line. 978138 Human
ah antigen melanoma AH antigen, initially defined by an antibody present in a melanoma patient, is a cell surface antigen found on approximately 65% of melanoma cell lines. 7175442 Human
ah antigen melanoma These IgM antibodies detect antigens that are identical or closely related to the AH antigen, a melanoma surface antigen that was initially defined by autologous antibody in a patient with melanoma. 6933476 Human
cenpf glioblastomas These analyses confirmed that the transcript levels of nine of the selected genes (COL4A2, FOXM1, MGP, TOP2A, CENPF, IGFBP4, VEGFA, ADD3, and CAMK2G) differed significantly in WHO grade II astrocytomas as compared to anaplastic astrocytomas and/or gliobla 12937144 Human
cenpf who grade ii astrocytomas These analyses confirmed that the transcript levels of nine of the selected genes (COL4A2, FOXM1, MGP, TOP2A, CENPF, IGFBP4, VEGFA, ADD3, and CAMK2G) differed significantly in WHO grade II astrocytomas as compared to anaplastic astrocytomas and/or gliobla 12937144 Human
cenpf anaplastic astrocytomas These analyses confirmed that the transcript levels of nine of the selected genes (COL4A2, FOXM1, MGP, TOP2A, CENPF, IGFBP4, VEGFA, ADD3, and CAMK2G) differed significantly in WHO grade II astrocytomas as compared to anaplastic astrocytomas and/or gliobla 12937144 Human
ah antigen melanoma II. Serological evaluation of the immune responses to the injection using allogeneic melanoma cell vaccine] Serological studies were performed on melanoma patients for the response of allogeneic melanoma cell vaccine derived from the melanoma cell line SK 6870307 Human
mitosin diffuse astrocytomas The expression of two novel proliferation-associated markers, mitosin and topoisomerase IIalpha (Topo IIalpha), was evaluated immunohistochemically in consecutive paraffin sections from 60 diffuse astrocytomas (grades 2 to 4) in relation to clinicopatholo 11556747 Human
mitosin astrocytomas It is concluded that the proliferative potential of astrocytomas, as measured by mitosin and Topo IIalpha immunostaining, conveys useful prognostic information, in addition to that obtained by standard clinicopathologic parameters. 11556747 Human

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