IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene COL5A2 Ensembl ENSG00000204262 Chromosome 2 Start 189604886 End 189752850
Description Collagen alpha-2(V) chain Precursor [Source:UniProtKB/Swiss-Prot;Acc:P05997]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2210
     Entrez Gene : 1290
     UCSC : uc002uqk.2
     GeneCards : 2210
     RefSeq : NM_000393
     CCDS : CCDS33350.1
     Uniprot : Q96QB0
     Interpro : Q96QB0
     OMIM : 120190
     GeneTests : COL5A2
     CGAP : COL5A2
     PMID : 1572660

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38420_at  1.53  6.77e-10  8.61e-9  1.94  6.02e-11  8.48e-10
 HG_U133A  221729_at  1.27  1.39e-25  1.60e-24  -5.85  1.81e-103  1.35e-102
 HG_U133A  221730_at  1.63  5.46e-32  9.65e-31  -1.16  6.05e-17  8.40e-17
 HG_U133_Plus2  221729_at  1.86  3.38e-27  1.70e-25  2.04  3.39e-25  8.54e-24
 HG_U133_Plus2  221730_at  1.26  1.22e-12  1.24e-11  1.42  1.42e-11  7.51e-11
 Stanford  13434  2.14  3.42e-5  1.60e-3  2.08  1.66e-4  3.94e-3
 Stanford  14196  1.99  2.27e-4  5.59e-3  1.74  4.99e-3  4.26e-2
 Stanford  21686  1.90  6.00e-4  1.04e-2  1.72  1.27e-3  1.65e-2
 Agilent_HS_21.6K  299  0.32  5.93e-3  3.10e-2  0.34  1.09e-3  5.81e-3
 Agilent_HS_21.6K  336  0.27  1.13e-2  5.03e-2  0.29  1.26e-3  6.53e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221729_at  -0.32  4.34e-1  9.12e-1  -0.35  2.64e-1  1.00e+0
 HG_U133A  221730_at  -0.51  2.87e-1  8.72e-1  -0.37  2.91e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38420_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221729_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221730_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221729_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221730_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13434    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14196    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21686    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 299    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 336    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
col5a2 tumours An analysis of other collagens showed that COL5A2 was not expressed in normal colon but was co-expressed with COL11A1 in the tumours. 11375892 Human
col5a2 colorectal cancer Our results suggest that stromal expression of COL11A1 and COL5A2 is associated with malignancy in colorectal cancer. 11375892 Human
col5a2 malignancy Our results suggest that stromal expression of COL11A1 and COL5A2 is associated with malignancy in colorectal cancer. 11375892 Human
col5a2 cancer Only BGN and COL5A2 were commonly downregulated, except for at early phase in fibroblasts, and a few genes showed controversial expression changes, with regard to previous reports in cancer cells. 15942647 Human
col5a2 carcinogenesis Colorectal carcinogenesis is associated with stromal expression of COL11A1 and COL5A2. 11375892 Human

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