IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CTSH Ensembl ENSG00000103811 Chromosome 15 Start 77001147 End 77024475
Description Cathepsin H Precursor (EC 3.4.22.16) [Contains Cathepsin H mini chain;Cathepsin H heavy chain;Cathepsin H light chain] [Source:UniProtKB/Swiss-Prot;Acc:P09668]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2535
     Entrez Gene : 1512
     UCSC : uc002ben.2
     GeneCards : 2535
     RefSeq : NM_004390
     CCDS : CCDS10308.1
     Uniprot : P09668
     Interpro : P09668
     OMIM : 116820
     GeneTests : CTSH
     CGAP : CTSH
     PMID : 2849458

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37021_at  -1.19  4.36e-10  5.80e-9  -2.05  2.04e-16  8.50e-15
 HG_U133A  202295_s_at  -1.06  4.93e-16  2.87e-15  -0.63  4.25e-20  6.18e-20
 HG_U133_Plus2  202295_s_at  -1.07  8.99e-16  1.33e-14  -1.94  1.66e-28  6.36e-27
 Stanford  6127  -1.37  1.82e-2  9.47e-2  -2.49  7.96e-7  8.15e-5
 Agilent_HS_21.6K  9490  -0.21  2.07e-1  3.82e-1  -0.60  1.72e-7  3.49e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202295_s_at  0.01  9.61e-1  9.98e-1  -0.50  4.67e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37021_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202295_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202295_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6127    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9490    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cathepsin h tumor Analysis of a truncated form of cathepsin H in human prostate tumor cells. 11796715 Human
cathepsin h high-grade prostatic intraepithelial neoplasia We found a significant increase in cathepsin H expression in high-grade prostatic intraepithelial neoplasia and carcinoma of the prostate. 11796715 Human
cathepsin h carcinoma of the prostate We found a significant increase in cathepsin H expression in high-grade prostatic intraepithelial neoplasia and carcinoma of the prostate. 11796715 Human
cathepsin h tumor Therefore, an increase in overall cathepsin H expression, particularly in the truncated form with a high secretion propensity, may affect cell biological behaviors such as those associated with tumor progression. 11796715 Human
cathepsin h tumours Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking. 10732746 Human
cathepsin h lung cancer Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking. 10732746 Human
cathepsin h human lung cancer In order to evaluate the role of cysteine peptidase cathepsin H (Cath H) in human lung cancer its protein levels were determined in 148 pairs of lung tumour tissue and adjacent non-tumourous lung parenchyma using the enzyme-linked immunosorbent assay tech 10732746 Human
cathepsin h tumour In order to evaluate the role of cysteine peptidase cathepsin H (Cath H) in human lung cancer its protein levels were determined in 148 pairs of lung tumour tissue and adjacent non-tumourous lung parenchyma using the enzyme-linked immunosorbent assay tech 10732746 Human
cathepsin h human colorectal carcinomas Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas. 10755408 Human
cathepsin h cancer Our analyses of cathepsin H activity levels and protein forms in human colorectal cancers compared to matched control mucosa support the concept that altered proteinase expression patterns may reflect both cancer stage and site. 10755408 Human
cathepsin h human colorectal cancers Our analyses of cathepsin H activity levels and protein forms in human colorectal cancers compared to matched control mucosa support the concept that altered proteinase expression patterns may reflect both cancer stage and site. 10755408 Human
cathepsin h colorectal cancer In contrast, cathepsin B and L activities analysed in the same paired extracts had been shown to be most frequently elevated in earlier stage carcinomas (Dukes' A and B), confirming that cathepsin H demonstrates a distinct pattern of expression durin 10755408 Human
cathepsin h carcinomas In contrast, cathepsin B and L activities analysed in the same paired extracts had been shown to be most frequently elevated in earlier stage carcinomas (Dukes' A and B), confirming that cathepsin H demonstrates a distinct pattern of expression durin 10755408 Human
cathepsin h cancers Although cathepsin H activities were most commonly elevated in Dukes' C cancers at all colon sites, both specific activity and C/N ratios were significantly higher for cancers of the left colon compared to other colon locations. 10755408 Human
cathepsin h cancers A subset of 43 paired extracts analysed on Western blots also revealed consistent changes in cathepsin H protein forms in cancers. 10755408 Human
cathepsin h cancers Normal mucosa typically showed a strong protein doublet at 31 and 29 kDa while cancers demonstrated decreased expression or total loss of the 31 kDa protein (90% of cases), equal or increased expression of the 29-kDa protein (67% of cases) and the new app 10755408 Human
cathepsin h cancers C/N ratios for cathepsin H enzyme activity correlated significantly with C/N ratios for the 29 kDa mature single-chain protein form (P < 0.001), with increased activity most commonly associated with elevated expression of 29-kDa cathepsin H but also with 10755408 Human
cathepsin h tumour Changes in cathepsin H expression were also detected by immunohistochemistry as elevated cathepsin H staining in tumour epithelial cells. 10755408 Human
cathepsin h renal-cell carcinomas Cathepsin H expression distinguishes oncocytomas from renal cell carcinomas. 10769721 Human
cathepsin h renal-cell carcinomas CONCLUSIONS: Cathepsin H histoscore on even cytoplasmic immunostaining is an excellent method for the distinction of oncocytomas and renal cell carcinomas. 10769721 Human
cathepsin h insulinoma Immunoreactivities for cathepsin H additionally were found in cell parts containing secretory granules of B-cells and insulinoma cells. 2559067 Human
cathepsin h insulinoma Cathepsin H immunoreactivities showed an other pattern: they were found regularly in the secretory granules of A- and B-cells and insulinoma cells, and in lysosomes of A-cells. 2559067 Human
cathepsin h metastatic melanoma Additionally, cathepsin H was measured in sera from 55 patients with primary skin melanoma and from 42 patients with metastatic melanoma. 9050938 Human
cathepsin h melanoma Additionally, cathepsin H was measured in sera from 55 patients with primary skin melanoma and from 42 patients with metastatic melanoma. 9050938 Human
cathepsin h metastatic melanoma The mean cathepsin H level was significantly higher for both groups of patients compared to normal sera level, being highest for metastatic melanoma patients. 9050938 Human
cathepsin h pancreas cancer Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization. 8641471 Human
cathepsin h pancreas cancer Their expression in cultured pancreas cancer cells, normal pancreas tissue, and normal exocrine pancreas cultures was examined by Northern blotting. cDNA clones can be grouped into two broad categories: (1) those corresponding to genes expressed at high l 8641471 Human
cathepsin h tumor Their expression in cultured pancreas cancer cells, normal pancreas tissue, and normal exocrine pancreas cultures was examined by Northern blotting. cDNA clones can be grouped into two broad categories: (1) those corresponding to genes expressed at high l 8641471 Human
cathepsin h glioma Expression and the role of cathepsin H in human glioma progression and invasion. 8640738 Human
cathepsin h glioma In this study, we determined the levels of cathepsin H in human glioma progression and the significance of cathepsin H in glioma cell invasion. 8640738 Human
cathepsin h anaplastic astrocytoma Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. 8640738 Human
cathepsin h tumor Western blotting confirmed the presence of authentic cathepsin H with a doublet at 27 and 25 kDa in normal brain tissue and tumor samples. 8640738 Human
cathepsin h glioblastoma Cathepsin H antibody inhibited the invasion of glioblastoma cell lines through Matrigel invasion assay. 8640738 Human
cathepsin h head and neck carcinoma To estimate the prognostic value of cathepsins B, H, L, D and stefins A and B in head and neck carcinoma, their concentrations in cytosols of primary tumours and adjacent normal tissue were measured (cathepsins B, D stefins A, B in 45, cathepsin L in 24 a 8839984 Human
cathepsin h primary tumours To estimate the prognostic value of cathepsins B, H, L, D and stefins A and B in head and neck carcinoma, their concentrations in cytosols of primary tumours and adjacent normal tissue were measured (cathepsins B, D stefins A, B in 45, cathepsin L in 24 a 8839984 Human
cathepsin h tumour Median concentrations of cathepsins B, L, and D were significantly higher in tumour than in the adjacent normal tissue (B and D: p < 0.0001; L: p = 0.004); cathepsin H concentration was higher in normal tissue (p = 0.001). 8839984 Human
cathepsin h tumour The values of cathepsins D, B and L were significantly higher in tumour tissue, whereas cathepsin H concentration was lower in tumour than in normal tissue. 7576236 Human
cathepsin h tumour Median cathepsin H values were 1.05 micrograms/mg and 2.20 micrograms/mg for tumour and normal tissue, respectively. 7576236 Human
cathepsin h tumours Pre-operative serum levels of CRP were inversely correlated with the activity of CLP and cathepsin H and collagenase in the tumours (rs = 0.332, 0.359 (P less than 0.05) and 0.302 (P = 0.05) respectively). 2986750 Human
cathepsin h amelanotic melanomas The isolated fractions consisting of necrotic tumor cells and inflammatory cells (alpha fraction) apparently contain a cysteine proteinase inhibitor, since both cathepsin B-like and cathepsin H activities in the beta fraction of B16 amelanotic melanomas c 3893687 Human
cathepsin h tumor The isolated fractions consisting of necrotic tumor cells and inflammatory cells (alpha fraction) apparently contain a cysteine proteinase inhibitor, since both cathepsin B-like and cathepsin H activities in the beta fraction of B16 amelanotic melanomas c 3893687 Human
cathepsin h b16 melanoma We have determined the subcellular distribution of this enzyme and three additional lysosomal hydrolases (cathepsin H, beta-hexosaminidase, and beta-glucuronidase) in normal murine liver and six metastatic variants of the B16 melanoma. 2824039 Human
cathepsin h b16 melanomas Cathepsin H and beta-glucuronidase activities were not localized in the plasma membrane fractions of the B16 melanomas. 3458210 Mouse
cathepsin h carcinosarcoma Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma. 2276418 Rat
cathepsin h tumor In addition to cathepsin B, these tumor cells also expressed the immunologically and functionally related cathepsin L, but not cathepsin H. Stefin A was found in HS-24 but not in SB-3 cells; stefin B was found in both cell types. 8014475 Human
cathepsin h breast cancer In cytosols of breast cancer tumour tissue in general, the level of cathepsin H was higher than those of cathepsins B and L in all samples tested. 1316176 Human
cathepsin h tumour In cytosols of breast cancer tumour tissue in general, the level of cathepsin H was higher than those of cathepsins B and L in all samples tested. 1316176 Human
cathepsin h brain neoplasms [Cathepsin H activity in the human brain and human brain neoplasms] The human brain cathepsin H is shown to be a specific cysteine aminopeptidase with the optimum activity at pH 6.0. 2588347 Human
cathepsin h glioblastomas Human brain tumours of neuroectodermal (astrocytomas and glioblastomas) and epithelial (meningiomas) origin were used to study the cathepsin H activity in the malignant brain tissue. 2588347 Human
cathepsin h astrocytomas Human brain tumours of neuroectodermal (astrocytomas and glioblastomas) and epithelial (meningiomas) origin were used to study the cathepsin H activity in the malignant brain tissue. 2588347 Human
cathepsin h meningiomas Human brain tumours of neuroectodermal (astrocytomas and glioblastomas) and epithelial (meningiomas) origin were used to study the cathepsin H activity in the malignant brain tissue. 2588347 Human
cathepsin h brain tumours Human brain tumours of neuroectodermal (astrocytomas and glioblastomas) and epithelial (meningiomas) origin were used to study the cathepsin H activity in the malignant brain tissue. 2588347 Human
cathepsin h benign tumours A significant increase in the aminopeptidase cathepsin H activity was found in malignant human brain tumours as compared to benign tumours and normal brain tissues. 2588347 Human
cathepsin h brain tumours A significant increase in the aminopeptidase cathepsin H activity was found in malignant human brain tumours as compared to benign tumours and normal brain tissues. 2588347 Human
cathepsin h gliomas Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. 8640738 Human
cathepsin h glioblastomas Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. 8640738 Human
cathepsin h cancer [Cysteine cathepsins secreted into the blood as markers of tumor growth] Cathepsin H was secreted into the blood plasma of cancer patients before and after surgery. 8686249 Human
cathepsin h recurrent tumor In the mandibular osteoradionecrosis group, there was a tendency for cathepsin H level to decrease, although only in cases free from recurrent tumor growth. 8686249 Human
cathepsin h tumor Constant levels of cathepsin H were maintained after specific treatment, even in tumor recurrence-free cases. 8686249 Human
cathepsin h skin melanoma Additionally, cathepsin H was measured in sera from 55 patients with primary skin melanoma and from 42 patients with metastatic melanoma. 9050938 Human
cathepsin h lung tumour In order to evaluate the role of cysteine peptidase cathepsin H (Cath H) in human lung cancer its protein levels were determined in 148 pairs of lung tumour tissue and adjacent non-tumourous lung parenchyma using the enzyme-linked immunosorbent assay tech 10732746 Human
cathepsin h mouth cancer [Activity of cathepsin H in blood and biopsies of patients with precancerous conditions and mouth cancer] The paper discusses the results of an investigation of cysteine cathepsin H levels in preneoplastic lesions and tumors of the oral cavity as measured 11785102 Human
cathepsin h precancerous conditions [Activity of cathepsin H in blood and biopsies of patients with precancerous conditions and mouth cancer] The paper discusses the results of an investigation of cysteine cathepsin H levels in preneoplastic lesions and tumors of the oral cavity as measured 11785102 Human
cathepsin h tumors [Activity of cathepsin H in blood and biopsies of patients with precancerous conditions and mouth cancer] The paper discusses the results of an investigation of cysteine cathepsin H levels in preneoplastic lesions and tumors of the oral cavity as measured 11785102 Human
cathepsin h prostate tumor Analysis of a truncated form of cathepsin H in human prostate tumor cells. 11796715 Human
cathepsin h cancer diseases The deduced cathepsin L-like protein sequence displays the structural signatures and phylogenetic relationships of cathepsin H, a protein that is known only in plants and animals and that is involved in the degradation of extracellular matrix components i 14665458 Human
cathepsin h tumor Cathepsin H activities, immunoreactivities and mRNA in most BCCs were higher than in normal skin, and the reactive cells were located between and around tumor nodules, but not in the tumor nests. 14767779 Human
cathepsin h tumor Cathepsin H of the peritumoral cells may either promote invasion of the tumor cells by degradation of the extracellular matrix or may reflect an elevated activity of the surrounding immunological cells. 14767779 Human
cathepsin h meningioma Some physicochemical properties of cathepsin H from human meningioma. 15627059 Human
cathepsin h brain tumors AIM: To compare some physicochemical properties of cathepsin H from human brain tumors and normal brain tissues. 15627059 Human
cathepsin h meningioma RESULTS: Cathepsin H was purified by 1795-fold from normal human brain tissue and by 2457-fold--from meningioma tissue. 15627059 Human
cathepsin h tumor V(max) for cathepsin H from meningioma was found to be 3.5 times higher than that of normal brain tissue, whilst K(m) of the enzyme from tumor tissue is 1.3 times lower than that from normal human brain. 15627059 Human
cathepsin h meningioma V(max) for cathepsin H from meningioma was found to be 3.5 times higher than that of normal brain tissue, whilst K(m) of the enzyme from tumor tissue is 1.3 times lower than that from normal human brain. 15627059 Human
cathepsin h meningioma The molecular weights of cathepsin H from normal human brain tissue and meningioma were 28 kDa and 25 kDa respectively. 15627059 Human
cathepsin h fibrous meningioma CONCLUSION: Cathepsin H isolated from human fibrous meningioma with microconcentric structures possesses higher activity levels and V(max) value and lower molecular weight than the enzyme from normal human neocortex tissue, without alteration in its pH op 15627059 Human
cathepsin h colorectal cancer Serum cathepsin H as a potential prognostic marker in patients with colorectal cancer. 15646835 Human
cathepsin h tumor Cathepsin H is a lysosomal cysteine protease that may participate in tumor progression. 15646835 Human
cathepsin h tumor Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevat 15645424 Mouse
cathepsin h lung tumors Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevat 15645424 Mouse
cathepsin h lung tumors Therefore, our findings indicate that Mgst1, cathepsin H and syndecan 1 should be further evaluated as markers capable of identifying patients with early stage lung tumors. 15645424 Human
ctsh cancer We previously investigated the correlations between the expression of 9216 genes and various chemosensitivities in a panel of 39 human cancer cell lines(1)) and found that the expression levels of AKR1B1 and CTSH were correlated with sensitivity and resis 14662023 Human

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