IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DSP Ensembl ENSG00000096696 Chromosome 6 Start 7486869 End 7531945
Description Desmoplakin (DP)(250/210 kDa paraneoplastic pemphigus antigen) [Source:UniProtKB/Swiss-Prot;Acc:P15924]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3052
     Entrez Gene : 1832
     UCSC : uc003mxp.1
     GeneCards : 3052
     RefSeq : NM_001008844
     CCDS : CCDS4501.1
     Uniprot : P15924
     Interpro : P15924
     OMIM : 125647
     GeneTests : DSP
     CGAP : DSP
     PMID : 1889810

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up - IHC- 16489176 J Clin Pathol. 2007 Jun;60(6):608-14.
up - Western- 11955647 Lung Cancer. 2002 May;36(2):133-41.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36133_at  1.57  1.12e-9  1.37e-8  3.59  8.22e-25  3.08e-22
 HG_U133A  200606_at  1.60  3.44e-28  4.73e-27  3.06  9.70e-112  9.15e-111
 HG_U133_Plus2  200606_at  2.04  5.41e-24  1.94e-22  3.47  4.72e-53  1.72e-49
 Stanford  1920  1.16  2.16e-3  2.39e-2  1.07  2.97e-2  1.18e-1
 Stanford  2425  1.21  9.15e-4  1.38e-2  0.87  8.45e-3  6.14e-2
 Stanford  14579  1.38  6.25e-2  1.81e-1  2.61  1.46e-5  6.99e-4
 Stanford  22477  1.36  8.30e-2  2.19e-1  2.62  6.62e-7  7.25e-5
 Agilent_HS_21.6K  19246  0.37  3.36e-3  2.00e-2  0.86  5.37e-9  1.76e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200606_at  0.17  7.47e-1  9.74e-1  0.55  2.90e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36133_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200606_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200606_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1920    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2425    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14579    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22477    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19246    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
desmoplakin striate palmoplantar keratoderma Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network. 15149499 Human
desmoplakin striate palmoplantar keratoderma Recently, mutations in desmoplakin have been shown to underlie some cases of the autosomal dominant disorder, striate palmoplantar keratoderma, as well as an autosomal recessive condition characterized by dilated cardiomyopathy, woolly hair, and keratoder 11841538 Human
desmoplakin keratoderma Recently, mutations in desmoplakin have been shown to underlie some cases of the autosomal dominant disorder, striate palmoplantar keratoderma, as well as an autosomal recessive condition characterized by dilated cardiomyopathy, woolly hair, and keratoder 11841538 Human
desmoplakin metastasis However, HOXD3 reduced the expression of TGF-beta-independent genes coding for desmosomal components such as desmoglein, desmoplakin and plakoglobin which are known to suppress tumor invasion and metastasis. 11850808 Human
desmoplakin tumor However, HOXD3 reduced the expression of TGF-beta-independent genes coding for desmosomal components such as desmoglein, desmoplakin and plakoglobin which are known to suppress tumor invasion and metastasis. 11850808 Human
desmoplakin striate palmoplantar keratoderma Genetic heterogeneity of striate palmoplantar keratoderma has been demonstrated with pathogenic mutations in the desmosomal proteins desmoplakin and desmoglein 1. 11982762 Human
desmoplakin endometrial carcinomas In this study, we analyzed the immunohistochemical expression and localization of beta- and gamma-catenin, molecular changes in the beta-catenin gene, and the subcellular localization of the desmosomal component protein, desmoplakin, by laser scanning mic 12068170 Human
dsp palmoplantar keratoderma It is interesting that a nonsense DSP mutation was reported elsewhere in the literature, inherited as a recessive trait and causing a biventricular dilative cardiomyopathy associated with palmoplantar keratoderma and woolly hairs. 12373648 Human
desmoplakin striate palmoplantar keratoderma Subsequently, either a haploinsufficiency of desmoplakin or a defect in desmoglein 1 was found to underlie the autosomal dominant condition Striate Palmoplantar Keratoderma. 11476106 Human
desmoplakin metastasis RESULTS: We found no qualitative correlation of desmoplakin or plakoglobin expression with risk of metastasis. 14744087 Human
desmoplakin keratoderma Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. 11063735 Human
desmoplakin keratoderma Here, we describe the first recessive human mutation, 7901delG, in the desmoplakin gene which causes a generalized striate keratoderma particularly affecting the palmoplantar epidermis, woolly hair and a dilated left ventricular cardiomyopathy. 11063735 Human
desmoplakin striate palmoplantar keratoderma Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency. 10594734 Human
desmoplakin striate palmoplantar keratoderma We now report a further case of a desmoplakin mutation in a proband with striate palmoplantar keratoderma that also results in a null allele and haploinsufficiency. 10594734 Human
desmoplakin palmoplantar keratoderma Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. 9887343 Human
desmoplakin primary carcinoma Two constitutive desmosomal molecules, desmoplakin (Dp) and plakoglobin (Pg), were examined in 26 samples of primary carcinoma of the head and neck. 10424382 Human
desmoplakin neoplasms MATERIALS AND METHODS: We analysed the expression of cell adhesion-related proteins desmoplakin and E-cadherin, BM components laminin and collagen IV, and BM receptor integrin alpha 6 in experimental preneoplastic changes and neoplasms of skin. 9615735 Mouse
desmoplakin oral squamous-cell carcinomas Previous studies have shown that metastasis of oral squamous cell carcinomas of the head and neck correlates with a reduction in immunohistochemical staining for desmoplakin and desmoglein at the invasion front. 9664902 Human
desmoplakin tumors Desmoplakin as one of the desmosomal plaque components has proven to be a reliable marker for diagnosis of meningeal tumors. 12845453 Human
desmoplakin meningioma Here we demonstrate by immunofluorescence microscopy, immunoblot and reverse transcription-PCR reactions that cells of arachnoidal tissue, of diverse meningioma subtypes and of a meningioma-derived cell line contain the full complement of the typical desm 12845453 Human
desmoplakin lymph-node metastases In this study, we semiquantified the desmosomal components desmoplakin I and II and desmoglein, in tissue sections using confocal laser scanning microscopy (LSM), and examined their relationship to the pathological type, the occurrence of lymph node metas 8697392 Human
desmoplakin basal-cell carcinoma Distribution of desmoplakin in normal cultured human keratinocytes and in basal cell carcinoma cells. 2476246 Human
desmoplakin basal-cell carcinoma In basal cell carcinoma cells desmoplakin is not restricted to desmosomes but also occurs in certain electron-dense bodies morphologically similar to those seen in NHEK maintained in low levels of Ca2+ and during early stages of desmosome assembly. 2476246 Human
desmoplakin squamous-cell carcinoma Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up-regulation of the mesenchymal marker vimentin. 12727836 Human
desmoplakin necrosis Two clinicopathologic and two biologic features had high specificity (87%-100%) but poor sensitivity (27%-59%): (1) clinical presentation associating erosive oral lesions with erythema multiforme-like, bullous pemphigoid-like, or lichen planus-like cutane 11004616 Human
desmoplakin meningeal tumors Desmoplakin as one of the desmosomal plaque components has proven to be a reliable marker for diagnosis of meningeal tumors. 12845453 Human
desmoplakin breast cancer Epidermal growth factor suppresses induction by progestin of the adhesion protein desmoplakin in T47D breast cancer cells. 15084247 Human
desmoplakin tumor Consequently, fully understanding the role of desmoplakin in capillary formation may lead to a novel approach for inhibiting vasculo- and angiogenesis in tumor formation. 15190119 Human
desmoplakin serous carcinomas For serous carcinomas, these include aldolase, desmoplakin, integrin-linked kinase, PKC, and metallopeptidase. 15381901 Human
desmoplakin lymph-node metastases We have studied a cohort of 200 primary tumors and 56 lymph node metastases from different anatomic sites of the head and neck region for changes in synthesis of E-cadherin, desmoplakin and desmoglein by immunohistochemistry (IHC). 15609307 Human
desmoplakin keratoderma BACKGROUND: Mutations in genes coding for 2 desmosomal proteins, desmoglein 1 and desmoplakin, have been shown to cause autosomal dominant keratoderma palmoplantaris striata. 15897387 Human
desmoplakin follicular dendritic cell sarcoma Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplak 16120143 Human
desmoplakin perineurioma Perineurioma is composed of elongated bipolar spindle-shaped tumour cells which are arranged in storiform, whorled, linear or lamellated growth patterns, The tumour cells stain positively for vimentin and EMA, and for CD 34 in a number of cases, but lack 10320997 Human
desmoplakin tumour Perineurioma is composed of elongated bipolar spindle-shaped tumour cells which are arranged in storiform, whorled, linear or lamellated growth patterns, The tumour cells stain positively for vimentin and EMA, and for CD 34 in a number of cases, but lack 10320997 Human
desmoplakin squamous cell carcinoma Squamous cell carcinoma lines engineered to express constitutively active Akt underwent EMT, characterized by down-regulation of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up-regulation of the mesenchymal marker vimentin. 12727836 Human
desmoplakin thymoma Western blot showed that the medium from both the thymoma and the follicular dendritic cell sarcoma cells recognized 190-kDa periplakin and 210-kDa envoplakin bands of human epithelial proteins as well as recombinant linker regions of periplakin, envoplak 16120143 Human
desmoplakin lymph node metastases In this study, we semiquantified the desmosomal components desmoplakin I and II and desmoglein, in tissue sections using confocal laser scanning microscopy (LSM), and examined their relationship to the pathological type, the occurrence of lymph node metas 8697392 Human
desmoplakin oral squamous cell carcinomas Previous studies have shown that metastasis of oral squamous cell carcinomas of the head and neck correlates with a reduction in immunohistochemical staining for desmoplakin and desmoglein at the invasion front. 9664902 Human
desmoplakin striate palmoplantar keratoderma (sppk) OBJECTIVES: To investigate the effects of heterozygous nonsense mutations in desmoplakin (Dp) and desmoglein (Dsg) 1 which cause the autosomal dominant disorder striate palmoplantar keratoderma (SPPK), focusing on changes in desmosome structure and compos 15149499 Human
desmoplakin lymph node metastases We have studied a cohort of 200 primary tumors and 56 lymph node metastases from different anatomic sites of the head and neck region for changes in synthesis of E-cadherin, desmoplakin and desmoglein by immunohistochemistry (IHC). 15609307 Human
desmoplakin pnet Formalin-fixed, paraffin-embedded sections from 23 primary and seven recurrent or metastatic cases of genetically confirmed ES/PNET were immunostained for claudin-1 and occludin (tight junction structural proteins), zonula occludens-1 (ZO-1, tight junctio 15920547 Human
desmoplakin meningiomas We have confirmed the meningothelial origin of these cell lines by assessing expression of vimentin and desmoplakin, characteristic markers for meningiomas. 16554968 Human
desmoplakin striate palmoplantar keratoderma Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin. 16628197 Human
dpii epithelial tumors [Expression of desmoplakin II in tumors] Desmoplakin II (DPII) is a new marker for identification of epithelium and epithelial tumors. 7656386 Human
dpii tumors [Expression of desmoplakin II in tumors] Desmoplakin II (DPII) is a new marker for identification of epithelium and epithelial tumors. 7656386 Human
dpii tumors Expression of DPII in 217 tumors cases was studied immunohistochemically by ABC method using an anti-DPII monoclonal antibody which reacts with tissue on formalin-fixed, paraffin-embedded sections. 7656386 Human
dpii epithelial tumors Immunohistochemical staining showed that 147 of the 163 epithelial tumors and bi-directional differentiation tumors expressed DPII (90.7%); 92 of the 163 tumors expressed CK (56.4%); 54 tumors lacking desmosome expressed neither DPII nor CK. 7656386 Human
desmoplakin papilloma Papilloma cells cultured under conditions of low extracellular Ca2+ were comprised of three subpopulations: cells reactive only with pemphigoid anti-serum, cells reactive only with desmoplakin antibody. 2691098 Human
desmoplakin papilloma However, like the normal cell lines, papilloma cells underwent a transition to predominantly a spinous cell population (i.e. reactive with pemphigus and desmoplakin antibody) in response to extracellular Ca2+. 2691098 Human
desmoplakin tumors Using a monoclonal antibody specific for desmoplakin, we evaluated 52 breast carcinomas, 25 normal tissues, 10 benign breast lesions, and 14 nonepithelial tumors. 2847570 Human
desmoplakin breast carcinomas Using a monoclonal antibody specific for desmoplakin, we evaluated 52 breast carcinomas, 25 normal tissues, 10 benign breast lesions, and 14 nonepithelial tumors. 2847570 Human
desmoplakin tumors Nonepithelial tumors were negative for desmoplakin. 2847570 Human
desmoplakin tumor Our study demonstrates that most infiltrating breast carcinomas retain abundant desmoplakin, regardless of tumor grade, degree of differentiation, or tumor type (duct or lobular). 2847570 Human
desmoplakin infiltrating breast carcinomas Our study demonstrates that most infiltrating breast carcinomas retain abundant desmoplakin, regardless of tumor grade, degree of differentiation, or tumor type (duct or lobular). 2847570 Human
desmoplakin undifferentiated carcinomas Desmosomes have a characteristic staining pattern that is easy to interpret, and monoclonal antibodies to desmoplakin may prove useful as markers for distinguishing undifferentiated carcinomas from nonepithelial cancers. 2847570 Human
desmoplakin cancers Desmosomes have a characteristic staining pattern that is easy to interpret, and monoclonal antibodies to desmoplakin may prove useful as markers for distinguishing undifferentiated carcinomas from nonepithelial cancers. 2847570 Human
desmoplakin neoplasms Synaptophysin was also demonstrated in NE neoplasms of "epithelial" type in which it was predominantly coexpressed with cytokeratins and desmoplakin. 3103452 Human
desmoplakin neoplasms The entire spectrum of lung NE neoplasms is epithelial for they express cytokeratin polypeptides and desmoplakin; subsets of the tumors coexpress cytokeratins and neurofilament proteins. 3290868 Human
desmoplakin tumors The entire spectrum of lung NE neoplasms is epithelial for they express cytokeratin polypeptides and desmoplakin; subsets of the tumors coexpress cytokeratins and neurofilament proteins. 3290868 Human
desmoplakin mzl Desmoplakin-positive DRC occurred in variable proportions in both FCCL and MZL. 3315178 Human
desmoplakin tumors Neither immunofluorescence microscopy nor biochemical analyses revealed cytokeratin polypeptides, neurofilament proteins, desmin, or desmoplakin in any of the tumors. 3531717 Human
desmoplakin tumor Two of the tumors showed focal cytokeratin- and desmoplakin-positivity as evidence of focal epithelial differentiation, while the tumor cells were in all cases positive for vimentin--the intermediate filament protein typical of (but not specific for) mese 3674283 Human
desmoplakin tumors Two of the tumors showed focal cytokeratin- and desmoplakin-positivity as evidence of focal epithelial differentiation, while the tumor cells were in all cases positive for vimentin--the intermediate filament protein typical of (but not specific for) mese 3674283 Human
desmoplakin meningiomas We consider this unusual combination, i.e., vimentin IF and desmoplakin plaques, to be a diagnostic feature for meningiomas, and we propose that the cytoskeletal property be used in differential diagnosis of intracranial tumors. 6387275 Human
desmoplakin intracranial tumors We consider this unusual combination, i.e., vimentin IF and desmoplakin plaques, to be a diagnostic feature for meningiomas, and we propose that the cytoskeletal property be used in differential diagnosis of intracranial tumors. 6387275 Human
desmoplakin ovarian tumor Desmoplakin was expressed only in one ovarian tumor. 7527220 Human
desmoplakin epithelial tumors [Expression of desmoplakin II in tumors] Desmoplakin II (DPII) is a new marker for identification of epithelium and epithelial tumors. 7656386 Human
desmoplakin tumors [Expression of desmoplakin II in tumors] Desmoplakin II (DPII) is a new marker for identification of epithelium and epithelial tumors. 7656386 Human
desmoplakin tumour Immunohistochemically, most of the tumour cells stained positive for epithelial membrane antigen and vimentin, but failed to stain for S-100 protein, neurofilament, desmoplakin, and CD34. 7821894 Human
desmoplakin oncogene Expression of desmosomal proteins (plakoglobin, desmoglein, desmoplakin) and uvomorulin was no longer detectable at the mRNA and protein level in the DTHMZ cells while both HaCaT cells and malignant variants (transfected with c-Ha-ras oncogene) expressed 8381787 Human
desmoplakin tumor Expression of desmosomal proteins (plakoglobin, desmoglein, desmoplakin) and uvomorulin was no longer detectable at the mRNA and protein level in the DTHMZ cells while both HaCaT cells and malignant variants (transfected with c-Ha-ras oncogene) expressed 8381787 Human
desmoplakin oncoproteins Fixed-cell enzyme-linked immunosorbent assay (ELISA) and Western blotting demonstrated that these cells contained high levels of epidermal growth factor-receptor (EGF-R), carbohydrate antigen 125 (CA 125), fibronectin and desmoplakin, but low levels of my 8508947 Human
desmoplakin oncoproteins However, untreated parental cells and clones N1-N3 were fast-growing (doubling times: 23-28 h), regularly shaped, polygonal cells ("cobblestone" monolayer) with low levels of EGF-R, CA 125, fibronectin and desmoplakin, but relatively higher amou 8508947 Human
desmoplakin scc of the oral cavity We have stained 65 specimens of primary SCC of the oral cavity (37 non-metastatic and 28 metatastic) with monoclonal antibodies to both desmoglein and desmoplakin. 8664118 Human
desmoplakin human endometrial carcinoma CONCLUSIONS: Reduction of desmoplakin I and II and desmoglein expression may play an important role in the invasiveness and metastatic activity of human endometrial carcinoma. 8697392 Human
desmoplakin metastasis The following markers were selected on their putative role in the process of metastasis and were studied using immunohistochemical and/or Southern blot techniques: proliferating cell nuclear antigen (PCNA), p53, retinoblastoma tumor-suppressor gene (Rb), 9109790 Human
desmoplakin tumor The following markers were selected on their putative role in the process of metastasis and were studied using immunohistochemical and/or Southern blot techniques: proliferating cell nuclear antigen (PCNA), p53, retinoblastoma tumor-suppressor gene (Rb), 9109790 Human
desmoplakin mammary carcinoma In this paper, we describe an improved differential display strategy that eliminates false positives, along with the identification of nine positive (TSC-22, CD-9, Na+/K+-ATPase alpha1, desmoplakin, CD-59, FKBP51, and three unknown genes) and one negative 9195978 Human
desmoplakin neoplasms of skin MATERIALS AND METHODS: We analysed the expression of cell adhesion-related proteins desmoplakin and E-cadherin, BM components laminin and collagen IV, and BM receptor integrin alpha 6 in experimental preneoplastic changes and neoplasms of skin. 9615735 Mouse
desmoplakin metastasis Previous studies have shown that metastasis of oral squamous cell carcinomas of the head and neck correlates with a reduction in immunohistochemical staining for desmoplakin and desmoglein at the invasion front. 9664902 Human
desmoplakin tumour The tumour cells stain positively for vimentin and EMA, and for CD34 in a number of cases, but lack positivity for S-100 protein, neurofilament and desmoplakin. 10095451 Human
desmoplakin metastasis The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. 10533469 Human
desmoplakin breast cancer The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. 10533469 Human
desmoplakin tumors Although immunohistochemical preparation of epithelial membrane antigen and desmoplakin I+II revealed the presence of non-neoplastic meningothelial cells in the superficial portion of the tumors, they were too few to play a significant role in the develop 1377859 Human
desmoplakin xanthomas Although immunohistochemical preparation of epithelial membrane antigen and desmoplakin I+II revealed the presence of non-neoplastic meningothelial cells in the superficial portion of the tumors, they were too few to play a significant role in the develop 1377859 Human
desmoplakin spindle cell sarcomas Also the glandular epithelial cells in synovial sarcoma showed desmoplakin immunoreactivity preferentially in a luminal distribution, but desmoplakin was absent in other spindle cell sarcomas. 1704194 Human
desmoplakin synovial sarcoma Also the glandular epithelial cells in synovial sarcoma showed desmoplakin immunoreactivity preferentially in a luminal distribution, but desmoplakin was absent in other spindle cell sarcomas. 1704194 Human
desmoplakin spindle cell sarcomas The presence of keratins 7 and 19 and desmoplakin is highly associated with morphologically observable epithelial differentiation restricted to synovial sarcoma among spindle cell sarcomas. 1704194 Human
desmoplakin synovial sarcoma The presence of keratins 7 and 19 and desmoplakin is highly associated with morphologically observable epithelial differentiation restricted to synovial sarcoma among spindle cell sarcomas. 1704194 Human
desmoplakin meningiomas Additional immunofluorescent staining revealed that these cells express vimentin and desmoplakin as well; these antigens have been found together only in normal arachnoid tissue and in meningiomas, which are the neoplastic derivatives of leptomeningeal ce 1724784 Human
desmoplakin testicular non-seminomatous germ cell tumors The patterns of cytoskeletal differentiation were studied in 20 testicular non-seminomatous germ cell tumors by immunohistochemistry, using diverse monoclonal antibodies specific for different intermediate filament (IF) proteins and for desmoplakin. 1725164 Human
desmoplakin cysts Other proteins associated with intercalated discs such as desmin or desmoplakin are not detected in the cysts. 2128183 Human
desmoplakin ovarian granulosa cell tumours The predominance of vimentin and the additional expression of cytokeratin subtypes 8 and 18, as well as the negative staining for epithelial membrane antigen, accorded with results previously reported, for ovarian granulosa cell tumours; the lack of expre 2212065 Human
desmoplakin carcinomas All carcinomas examined synthesized large amounts of cytokeratins as well as of desmosomal proteins such as desmoplakin(s) but differed from the normal tissue by the specific cytokeratin pattern expressed and by their heterogeneity of expression, which in 2423830 Human
desmoplakin tumors In these tumors, synaptophysin was invariably coexpressed with cytokeratin filaments and desmoplakin, as well as, occasionally, with NFP. 2442053 Human
desmoplakin basal cell carcinoma Distribution of desmoplakin in normal cultured human keratinocytes and in basal cell carcinoma cells. 2476246 Human
desmoplakin basal cell carcinoma In basal cell carcinoma cells desmoplakin is not restricted to desmosomes but also occurs in certain electron-dense bodies morphologically similar to those seen in NHEK maintained in low levels of Ca2+ and during early stages of desmosome assembly. 2476246 Human
desmoplakin melanoma Desmoplakin, another marker of epithelial differentiation, was not found in melanoma cells. 2481151 Human
desmoplakin striate palmoplantar keratoderma Recently, the first example of a human mutation in the gene encoding the desmosomal plaque protein, desmoplakin, has been described in a patient with autosomal dominant striate palmoplantar kerato-derma. 10594734 Human
desmoplakin leukemia The specificity of antibodies to TLRs was tested on a human monocyte leukemia cell line, umbilical vein endothelial cells (HUVEC), and periodontal ligament fibroblasts (PDLF) with the examination for the TLR gene expression by the reverse transcription-po 14709406 Human
desmoplakin primary tumors We have studied a cohort of 200 primary tumors and 56 lymph node metastases from different anatomic sites of the head and neck region for changes in synthesis of E-cadherin, desmoplakin and desmoglein by immunohistochemistry (IHC). 15609307 Human
desmoplakin palmoplantar keratoderma Mutations in the plakoglobin and desmoplakin genes have been identified to underlie recessive ARVC associated with woolly hair and palmoplantar keratoderma (Naxos disease), while mutations in plakophilin2, desmoglein2 as well as desmoplakin have been iden 16698823 Human
dsp metastasis Of the 64 genes, 11 are related to cancer metastasis (APC, CDH8, IL8RB, LY6D, PCDHGA12, DSP, NID, ENPP2, CCR2, CASP8, and CASP10) and eight are involved in apoptosis (CASP8, CASP10, PIK3R1, BCL2, SON, INHA, PSEN1, and BIK). 17194181 Human
dsp cancer Of the 64 genes, 11 are related to cancer metastasis (APC, CDH8, IL8RB, LY6D, PCDHGA12, DSP, NID, ENPP2, CCR2, CASP8, and CASP10) and eight are involved in apoptosis (CASP8, CASP10, PIK3R1, BCL2, SON, INHA, PSEN1, and BIK). 17194181 Human
desmoplakin palmoplantar keratoderma Case report of a Spanish patient with arrhythmogenic right ventricular cardiomyopathy and palmoplantar keratoderma without plakoglobin and desmoplakin gene modifications. 17045679 Human
desmoplakin squamous cell carcinoma (scc) AIMS: To investigate the modulation of cellular retinol-binding protein (CRBP)-1 and the desmosomal plaque proteins plakophilin (PKP)-1 and desmoplakin (DP) in correlation with the Ki67+ proliferation index (PI) during the progression of cervical squamous 17593084 Human
desmoplakin cervical squamous intraepithelial lesions AIMS: To investigate the modulation of cellular retinol-binding protein (CRBP)-1 and the desmosomal plaque proteins plakophilin (PKP)-1 and desmoplakin (DP) in correlation with the Ki67+ proliferation index (PI) during the progression of cervical squamous 17593084 Human
dsp tumour DSP and plakoglobin were predominantly present at central, more differentiated tumour cells, whereas DSC3 showed a stronger staining in the peripheral basal cells of SCC tumour areas. 16489176 Human
dsp invasive human breast cancers WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN. 18179684 others
desmoplakin striate palmoplantar keratoderma OBJECTIVES: To investigate the effects of heterozygous nonsense mutations in desmoplakin (Dp) and desmoglein (Dsg) 1 which cause the autosomal dominant disorder striate palmoplantar keratoderma (SPPK), focusing on changes in desmosome structure and compos 15149499 Human
desmoplakin squamous cell carcinoma AIMS: To investigate the modulation of cellular retinol-binding protein (CRBP)-1 and the desmosomal plaque proteins plakophilin (PKP)-1 and desmoplakin (DP) in correlation with the Ki67+ proliferation index (PI) during the progression of cervical squamous 17593084 Human

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