IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ENC1 Ensembl ENSG00000171617 Chromosome 5 Start 73958991 End 73972273
Description Ectoderm-neural cortex protein 1 (ENC-1)(p53-induced gene 10 protein)(Nuclear matrix protein NRP/B)(Kelch-like protein 37) [Source:UniProtKB/Swiss-Prot;Acc:O14682]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3345
     Entrez Gene : 8507
     UCSC : uc003kdc.3
     GeneCards : 3345
     RefSeq : NM_003633
     CCDS : CCDS4021.1
     Uniprot : O14682
     Interpro : O14682
     OMIM : 605173
     GeneTests : ENC1
     CGAP : ENC1
     PMID : 9305847

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39542_at  0.71  5.53e-8  4.79e-7  0.07  5.27e-1  6.27e-1
 HG_U133A  201340_s_at  1.01  2.48e-11  9.96e-11  4.91  1.07e-75  3.93e-75
 HG_U133A  201341_at  0.93  1.51e-20  1.24e-19  1.72  6.13e-43  1.24e-42
 HG_U133_Plus2  201340_s_at  0.83  7.70e-7  3.55e-6  -0.45  4.82e-2  6.92e-2
 HG_U133_Plus2  201341_at  1.10  4.52e-17  7.76e-16  0.50  2.81e-5  6.79e-5
 Stanford  11875  1.48  3.80e-3  3.45e-2  0.53  2.65e-1  5.04e-1
 Stanford  16214  1.58  1.22e-2  7.32e-2  0.84  3.76e-2  1.40e-1
 Stanford  20739  1.73  8.86e-4  1.35e-2  0.85  2.24e-2  1.16e-1
 Agilent_HS_21.6K  894  0.37  4.62e-4  4.10e-3  0.03  6.88e-1  7.96e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201340_s_at  -1.13  1.19e-3  5.17e-1  0.14  5.94e-1  1.00e+0
 HG_U133A  201341_at  -0.83  4.13e-3  6.53e-1  0.29  1.85e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39542_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201340_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201341_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201340_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201341_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11875    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16214    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20739    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 894    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
enc1 colorectal carcinomas Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. 11691783 Human
enc1 primary colon cancer Semiquantitative reverse transcription-PCR experiments revealed that expression of ENC1 was increased in more than two-thirds of 24 primary colon cancer tissues that we examined compared with corresponding noncancerous mucosae. 11691783 Human
enc1 colon cancer Introduction of exogenous ENC1 increased the growth rate of HCT116 colon cancer cells in serum-depleted medium. 11691783 Human
enc1 colon cancer In other experiments, overexpression of ENC1 in HT-29 colon cancer cells suppressed the usual increase of two differentiation markers, in response to treatment with sodium butyrate, a differentiation-inducible agent. 11691783 Human
enc-1 nervous system tumors Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors. 9683534 Human
enc-1 nervous system tumors The human ENC-1 gene appeared to be highly expressed in adult brain and spinal cord, and in a number of cell lines derived from nervous system tumors we detected low steady-state levels of ENC-1 mRNA. 9683534 Human
enc-1 neuroblastoma We used a neuroblastoma differentiation model, the retinoic acid-induced neuronal differentiation of SMS-KCNR cells, to study the regulation of the ENC-1 gene during neural crest cell differentiation. 9683534 Human
enc-1 tumors These results suggest that ENC-1 expression plays a role during differentiation of neural crest cells and may be down regulated in neuroblastoma tumors. 9683534 Human
enc-1 neuroblastoma These results suggest that ENC-1 expression plays a role during differentiation of neural crest cells and may be down regulated in neuroblastoma tumors. 9683534 Human
ccl28 hodgkin's disease Expression of CCL28 by Reed-Sternberg cells defines a major subtype of classical Hodgkin's disease with frequent infiltration of eosinophils and/or plasma cells. 14982853 Human
ectodermal-neural cortex colorectal carcinomas Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. 11691783 Human
enc-1 hairy-cell leukemia Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia. 15459180 Human
enc-1 tumors ENC-1 has previously been shown to be overexpressed in several malignancies, and is believed to play a critical regulatory role in malignant transformation of various tumors. 15459180 Human
enc-1 hcl Importantly, subsequent analysis of ENC-1 in purified primary HCL tumor cells revealed a striking upregulation of ENC-1 in all 26 patients examined, compared with normal peripheral blood lymphocytes from healthy donors. 15459180 Human
enc-1 tumor Importantly, subsequent analysis of ENC-1 in purified primary HCL tumor cells revealed a striking upregulation of ENC-1 in all 26 patients examined, compared with normal peripheral blood lymphocytes from healthy donors. 15459180 Human
enc-1 hcl Altogether, these results suggest that upregulation of ENC-1 contributes to the development of HCL and provides new information on the possible dysregulation of ENC-1 including expression of a novel antisense gene, ENC-1AS. 15459180 Human
enc 1 tumors In addition, a t-test analysis identified largely non-overlapping genes with differential expression in the tumors subgroups; e.g. in Group I tumors the putative oncogene ENC 1 was found highly over-expressed vs Group II adenomas. 15757864 Human
enc 1 adenomas In addition, a t-test analysis identified largely non-overlapping genes with differential expression in the tumors subgroups; e.g. in Group I tumors the putative oncogene ENC 1 was found highly over-expressed vs Group II adenomas. 15757864 Human

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