IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FEN1 Ensembl ENSG00000168496 Chromosome 11 Start 61316726 End 61321284
Description Flap endonuclease 1 (FEN-1)(EC 3.1.-.-)(Flap structure-specific endonuclease 1)(Maturation factor 1)(MF1)(hFEN-1)(DNase IV) [Source:UniProtKB/Swiss-Prot;Acc:P39748]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3650
     Entrez Gene : 2237
     UCSC : uc001nsg.2
     GeneCards : 3650
     RefSeq : NM_004111
     CCDS : CCDS8010.1
     Uniprot : P39748
     Interpro : P39748
     OMIM : 600393
     GeneTests : FEN1
     CGAP : FEN1
     PMID : 7774922

< Top >


Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 13/13(100%) Western- 14562054 Oncogene. 2003 Oct 16;22(46):7243-6.

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1515_at  0.94  1.20e-8  1.18e-7  1.83  7.11e-14  1.79e-12
 HG_U95  1516_g_at  0.93  3.19e-9  3.60e-8  1.79  3.67e-14  9.82e-13
 HG_U95  41583_at  1.29  2.33e-13  5.60e-12  2.27  1.01e-14  3.04e-13
 HG_U133A  204767_s_at  1.02  6.74e-36  1.49e-34  0.07  3.06e-1  3.16e-1
 HG_U133A  204768_s_at  1.01  1.34e-34  2.76e-33  1.42  1.49e-33  2.62e-33
 HG_U133_Plus2  204767_s_at  1.17  2.01e-18  4.04e-17  1.57  1.47e-29  6.38e-28
 HG_U133_Plus2  204768_s_at  1.15  5.06e-25  2.02e-23  1.88  5.53e-39  8.79e-37
 Stanford  13177  1.29  5.47e-5  2.16e-3  1.74  4.44e-6  2.75e-4
 Agilent_HS_21.6K  19504  0.14  6.26e-4  5.22e-3  0.22  5.96e-5  5.15e-4

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204767_s_at  0.37  2.22e-1  8.43e-1  -0.02  8.83e-1  1.00e+0
 HG_U133A  204768_s_at  -0.01  9.55e-1  9.98e-1  -0.06  6.95e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1515_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 1516_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41583_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204767_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204768_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204767_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204768_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13177    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19504    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fen1 tumor Fen1 is a key enzyme for the maintenance of genetic stability in archaea and eukaryotes and is classified as a tumor suppressor. 15131255 Human
fen1 tumor Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. 12119409 Mouse
fen1 cancer Because mutations in some genes involved in these processes cause cancer predisposition, we investigated the possibility that Fen1 may function in tumorigenesis of the gastrointestinal tract. 12119409 Human
fen1 cancer Because one copy of the Fen1 gene remained intact in tumors, Fen1 haploinsufficiency appears to lead to rapid progression of cancer. 12119409 Mouse
fen1 tumors Because one copy of the Fen1 gene remained intact in tumors, Fen1 haploinsufficiency appears to lead to rapid progression of cancer. 12119409 Mouse
fen-1 cancers FEN-1 mutations altering PCNA binding should reduce activity during replication, likely causing DNA repeat expansions as seen in some cancers and genetic diseases. 9778254 Human
fen1 human lung cancer Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer. 14562054 Human
fen1 human lung cancer Since Flap endonuclease1 (Fen1), which functions in the base excision repair system, has been shown to be involved in tumor progression of mouse models with microsatellite instability in a haplo-insufficient manner, we performed expression and mutation an 14562054 Human
fen1 tumor Since Flap endonuclease1 (Fen1), which functions in the base excision repair system, has been shown to be involved in tumor progression of mouse models with microsatellite instability in a haplo-insufficient manner, we performed expression and mutation an 14562054 Mouse
fen1 lung cancer Reverse transcriptase PCR analysis revealed that all 49 lung cancer cell lines (20 small cell lung cancers (SCLCs) and 29 non-small cell lung cancers (NSCLCs)) expressed FEN1. 14562054 Human
fen1 small-cell lung cancers Reverse transcriptase PCR analysis revealed that all 49 lung cancer cell lines (20 small cell lung cancers (SCLCs) and 29 non-small cell lung cancers (NSCLCs)) expressed FEN1. 14562054 Human
fen1 non-small cell lung cancers Reverse transcriptase PCR analysis revealed that all 49 lung cancer cell lines (20 small cell lung cancers (SCLCs) and 29 non-small cell lung cancers (NSCLCs)) expressed FEN1. 14562054 Human
fen1 lung cancer FEN1 protein was abundantly expressed in all 23 lung cancer cell lines (10 SCLCs and 13 NSCLCs) and was expressed at lower levels in three of four normal lung epithelial culture controls. 14562054 Human
fen1 lung cancer Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer. 14562054 Human
fen1 endometrial carcinomas Thus, we screened 16 endometrial carcinomas with microsatellite instability for alterations in FEN1 (the human homolog of RTH) and in MSH3 (refs 12-14). 8782829 Human
fen1 endometrial carcinoma Although we found no FEN1 mutations, a frameshift mutation in MSH3 was observed in an endometrial carcinoma and in an endometrial carcinoma cell line. 8782829 Human
rad2 xeroderma pigmentosum An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. 7510366 Human
fen1 human gastric cancer In particular, CDC20 and MT2A represent a potential biomarker of human gastric cancer. 15701830 Human
fen1 tumor PIN1, FEN1, and cABL up-regulation and LMNB1, AREG, RhoB, CCNG, TYMS, F3, and MGMT down-regulation suggest that methionine stress sensitizes the tumor cells to DNA-alkylating drugs, 5-fluorouracil, and radiation. 16170025 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.