IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GLI3 Ensembl ENSG00000106571 Chromosome 7 Start 41967072 End 42243137
Description Zinc finger protein GLI3 [Source:UniProtKB/Swiss-Prot;Acc:P10071]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4319
     Entrez Gene : 2737
     UCSC : uc011kbh.1
     GeneCards : 4319
     RefSeq : NM_000168
     CCDS : CCDS5465.1
     Uniprot : P10071
     Interpro : P10071
     OMIM : 165240
     GeneTests : GLI3
     CGAP : GLI3
     PMID : 2118997

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 9.09 11 1 100.00 1 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
NCI-H2122 AD c.2818C>A p.P940T Substitution - Missense Heterozygous 7:41972378-41972378 

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40358_at  -0.09  6.20e-1  7.10e-1  0.73  1.12e-2  2.55e-2
 HG_U133A  205201_at  -0.04  6.03e-1  6.50e-1  0.24  1.64e-1  1.72e-1
 HG_U133_Plus2  1569342_at  -0.38  9.55e-2  1.47e-1  -0.33  1.88e-1  2.37e-1
 HG_U133_Plus2  205201_at  -0.39  6.38e-3  1.37e-2  0.50  2.33e-4  4.93e-4
 HG_U133_Plus2  227376_at  -0.60  5.67e-8  3.12e-7  -0.04  7.09e-1  7.53e-1
 Stanford  15640  -0.23  5.56e-1  7.24e-1  0.16  7.48e-1  8.78e-1
 Agilent_HS_21.6K  12957  -0.05  5.50e-1  7.14e-1  0.01  8.79e-1  9.27e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205201_at  -0.06  7.95e-1  9.82e-1  0.16  3.10e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40358_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205201_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1569342_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205201_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227376_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15640    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12957    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
gli3 tumor Although the PTCH protein has an unknown function in urothelial cells, the detection of the PTCH, SMOH and GLI3 transcripts in normal urothelium and TCC cell lines and rare PTCH mutations in tumor samples suggest that the HH pathway may have a role in con 9764827 Human
gli3 colorectal carcinoma Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells. 15072830 Human
gcps leukemia To our knowledge, this is the first report of a patient with GCPS and leukemia. 15390181 Human
gcps medulloblastoma We performed a clinical evaluation for Greig cephalopolysyndactyly syndrome (GCPS) in four medulloblastoma families, who exhibited macrocephaly as the only finding consistent with the diagnosis of GCPS. 15759260 Human
gli3 bcc Because Gli1, but not Gli3, acts as a target and mediator of Shh signalling, our results suggest that expression of Gli1 in basal cells induces BCC formation. 9349822 Human
gli3 medulloblastomas GLI3 is not mutated commonly in sporadic medulloblastomas. 12115313 Human
gli3 medulloblastoma METHODS: The authors describe a patient with hereditary Greig syndrome, which was caused by mutations in GLI3, and medulloblastoma. 12115313 Human
gli3 medulloblastomas They also sequenced the GLI3 gene, including all exon-intron boundaries, in an additional 12 sporadic medulloblastomas. 12115313 Human
gli3 medulloblastoma CONCLUSIONS: Gli3 is mutated rarely in medulloblastoma. 12115313 Human
gli3 glioblastomas Their downstream molecules, Gli1, Gli2, and Gli3, are oncogenes of glioblastomas. 12241103 Human
gli3 acute lymphoblastic leukemia Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes. 15390181 Human
gli3 synovial chondromatosis To determine if hedgehog-mediated transcription predisposes to synovial chondromatosis, the extra-toes mutant mouse, which harbours a heterozygous mutation in the hedgehog transcriptional repressor, Gli3, resulting in decreased expression of Gli3 protein, 15834844 Mouse
gli3 synovial chondromatosis Eighty-five per cent of Gli3 mutant mice developed synovial chondromatosis at 18 months of age, compared with 30% of wild-type littermates (p < 0.05). 15834844 Mouse
gli3 synovial chondromatosis Three of the ten Gli3 mutant mice treated with triparanol, which blocks hedgehog signalling upstream of the Gli transcription factors, developed synovial chondromatosis, compared with eight of ten control mice. 15834844 Mouse
gli3 promyelocytic leukaemia Here we identify a genetic interaction between Gli3 (GLI-Kruppel family member 3) and Plzf (promyelocytic leukaemia zinc finger, also known as Zbtb16 and Zfp145), which is required specifically at very early stages of limb development for all proximal car 16015334 Human
gli3 glioblastoma Glioblastoma 3 (Gli3) is a transcription factor involved in patterning and oncogenesis. 15855276 Human
greig cephalopolysyndactyly syndrome medulloblastoma We performed a clinical evaluation for Greig cephalopolysyndactyly syndrome (GCPS) in four medulloblastoma families, who exhibited macrocephaly as the only finding consistent with the diagnosis of GCPS. 15759260 Human
phs hamartoma Pallister-Hall syndrome (PHS, MIM #146510) is characterized by central and postaxial polydactyly, hypothalamic hamartoma (HH), bifid epiglottis, imperforate anus, renal abnormalities, and pulmonary segmentation anomalies. 14708104 Human
phs hamartoma Pallister-Hall syndrome (PHS) is a rare, single-gene, malformation syndrome that includes central polydactyly, hypothalamic hamartoma, bifid epiglottis, endocrine dysfunction, and other anomalies. 15617553 Human
phs hamartomas Results: All isolated HH patients had a history of seizures, compared with 13 of 40 PHS patients (all PHS patients with seizures had hamartomas). 15660767 Human
phs hamartoma The T2 signal of the hamartoma was isointense to gray matter in the majority of PHS patients, but showed a significant increase in all but one patient with isolated HH. 15660767 Human
dna-binding protein acute myelogenous leukemia (aml) Many cases of acute myelogenous leukemia (AML) are characterized by non-random chromosomal translocations that fuse a DNA-binding protein with a transcriptional regulator, which in turn may aberrantly recruit a co-repressor complex. 15669080 Human

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