IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GRB7 Ensembl ENSG00000141738 Chromosome 17 Start 35147713 End 35157070
Description Growth factor receptor-bound protein 7 (GRB7 adapter protein)(Epidermal growth factor receptor GRB-7)(B47) [Source:UniProtKB/Swiss-Prot;Acc:Q14451]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 4567
     Entrez Gene : 2886
     UCSC : uc002hsr.2
     GeneCards : 4567
     RefSeq : NM_001030002
     CCDS : CCDS11345.1
     Uniprot : Q14451
     Interpro : Q14451
     OMIM : 601522
     GeneTests : GRB7
     CGAP : GRB7

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
2 1.01 199 2 1.06 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16802 AD c.663G>T p.Q221H Substitution - Missense Heterozygous 17:35153249-3515324918948947
17262 AD c.1073G>C p.C358S Substitution - Missense Heterozygous 17:35155083-3515508318948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1680_at  0.35  8.80e-4  2.81e-3  0.19  6.71e-2  1.17e-1
 HG_U133A  210761_s_at  0.36  7.21e-7  1.88e-6  -2.26  3.86e-48  8.52e-48
 HG_U133_Plus2  210761_s_at  1.11  2.52e-16  3.96e-15  1.00  1.95e-7  6.27e-7
 Stanford  1336  1.18  1.87e-3  2.19e-2  0.52  2.52e-1  4.89e-1
 Stanford  20671  1.30  6.02e-4  1.04e-2  0.68  8.57e-2  2.45e-1
 Agilent_HS_21.6K  9356  0.04  3.87e-1  5.74e-1  0.02  2.52e-1  4.05e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210761_s_at  -0.28  2.13e-1  8.38e-1  0.15  3.85e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210761_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210761_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1336    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20671    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9356    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
grb7 cancers These peptides will be useful in the development of targeted molecular therapeutics for cancers overexpressing Grb7 and in the development of Grb7-specific inhibitors to gain a complete understanding of the physiological role of Grb7. 11809769 Human
grb7 cancer GRB7 is tightly linked to ERBB2 and is coamplified and coexpressed with this gene in several cancer types. 11956097 Human
grb7 embryonal carcinoma Stimulation of endogenous EphB1 in embryonal carcinoma P19 cells with its ligand ephrinB1 increased its association with Grb7, which is consistent with a role for the autophosphorylation of EphB1. 12223469 Human
grb7 tumor Various isoforms of Grb10 have been shown to regulate cell proliferation and apoptosis, whereas Grb7 has been found to regulate cell migration and also implicated in tumor progression. 11607834 Human
grb7 breast cancer We show here that Rnd1 and Grb7 interact, in two-hybrid assays, in vitro, and in pull-down experiments performed with SK-BR3, a breast cancer cell line that overexpresses Grb7. 10664463 Human
grb7 esophageal carcinoma Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. 10797316 Human
growth factor receptor-bound protein 7 tumor We have previously reported the association of tumor cell invasion with expression of growth factor receptor-bound protein 7 (Grb7). 10797316 Human
grb7 tumor We have previously reported the association of tumor cell invasion with expression of growth factor receptor-bound protein 7 (Grb7). 10797316 Human
grb7 human esophageal carcinomas In the present study, Grb7 expression was analyzed in human esophageal carcinomas with or without metastatic spread. 10797316 Human
grb7 lymph-node metastases The Grb7 protein was overexpressed in 14 of 31 esophageal carcinomas as compared to the adjacent normal mucosa (45%) and this finding was significantly correlated with the presence of lymph node metastases. 10797316 Human
grb7 esophageal carcinomas The Grb7 protein was overexpressed in 14 of 31 esophageal carcinomas as compared to the adjacent normal mucosa (45%) and this finding was significantly correlated with the presence of lymph node metastases. 10797316 Human
grb7 esophageal carcinoma We also identified that Grb7 protein in esophageal carcinoma cells was phosphorylated on tyrosine by epidermal growth factor as well as attachment to extracellular matrix proteins including fibronectin. 10797316 Human
grb7 esophageal carcinoma Furthermore, ectopic expression of a Grb7-SH2 dominant-negative fragment inhibited the fibronectin-dependent phosphorylation of endogenous Grb7, and reduced migration of esophageal carcinoma cells into fibronectin. 10797316 Human
grb7 human esophageal carcinoma Our results suggest a role of Grb7 mediated signal transduction in generation of an invasive cell phenotype against extracellular matrix, and thus contributes to metastatic progression of human esophageal carcinoma. 10797316 Human
grb7 cancer The molecular adapter Grb7 is likely to be implicated in the development of certain cancer types. 10803466 Human
grb7 tumor Recent studies have suggested that various isoforms of Grb10 play important roles in mediating insulin/insulin-like growth factor regulation of cell proliferation and apoptosis, whereas Grb7 mediates signaling pathways from FAK and EphB1 receptor to regul 14766359 Human
grb7 human breast cancer In human breast cancer cell lines, co-immunoprecipitation of Grb7 with both receptors was detected upon heregulin stimulation. 9516479 Human
grb7 esophageal carcinoma A novel variant of human Grb7 is associated with invasive esophageal carcinoma. 9710451 Human
grb7 esophageal carcinoma The wild-type Grb7 protein, but not the Grb7V isoform, is rapidly tyrosyl phosphorylated in response to EGF stimulation in esophageal carcinoma cells. 9710451 Human
grb7 esophageal carcinoma Finally, transfection of an antisense Grb7 RNA expression construct lowered endogenous Grb7 protein levels and suppressed the invasive phenotype exhibited by esophageal carcinoma cells. 9710451 Human
grb7 human esophageal carcinomas These findings suggest that Grb7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas. 9710451 Human
grb7 cancer Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. 9794242 Human
grb7 cancers Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. 9794242 Human
grb7 esophageal carcinoma Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. 8988034 Human
grb7 breast carcinomas The Grb7 gene has been found to be coamplified with Her2/erbB2 in breast carcinomas. 8988034 Human
grb7 human esophageal cancers In this study, Grb7 expression was studied in 32 human esophageal cancers. 8988034 Human
grb7 cancers Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. 8988034 Human
grb7 esophageal cancers Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. 8988034 Human
grb7 tumor It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not sh 8988034 Human
grb7 esophageal carcinomas It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not sh 8988034 Human
grb7 human esophageal cancer These findings suggest a possible relationship of Grb7 signaling in association with expression of tyrosine kinase receptors in aggressive human esophageal cancer. 8988034 Human
grb-7 primary gastric cancer Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. 9125150 Human
grb7 human breast cancers The Src homology 2 (SH2) domain-containing protein Grb7 and the erbB2 receptor tyrosine kinase are overexpressed in a subset of human breast cancers. 9079677 Human
grb7 breast cancers The functions of Grb7 and Grb10 are unknown, but Grb7 is overexpressed in certain breast cancers, where it is bound to the growth factor receptor HER2, while Grb10 has been implicated in insulin signaling. 9142991 Human
grb-7 esophageal cancer CAB1, GRB-7, and c-ERBB-2 were overexpressed in gastric and esophageal cancer cells in correspondence with the amplification. 9270027 Human
grb7 breast cancer Grb7 is an SH2 and PH domain-containing molecule that is known to be overexpressed in some breast cancer tissues and cell lines. 8940081 Human
grb7 breast cancer Furthermore, complex formation between Shc and Grb7 was observed after ligand stimulation of PDGF alpha- or beta-receptors in cells transfected with Grb7 cDNA or in the breast cancer cell line BT-474. 8940081 Human
grb7 mouse mammary tumor In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human
grb7 noninvasive ductal carcinoma In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Mouse
grb7 tumors In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Mouse
grb-7 breast cancer The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. 7907978 Human
grb-7 breast cancer We find that GRB-7 is amplified in concert with HER2 in several breast cancer cell lines and that GRB-7 is overexpressed in both cell lines and breast tumors. 7907978 Human
grb-7 breast tumors We find that GRB-7 is amplified in concert with HER2 in several breast cancer cell lines and that GRB-7 is overexpressed in both cell lines and breast tumors. 7907978 Human
grb-7 breast cancers The fact that GRB-7 and HER2 are both overexpressed and bound tightly together suggests that this basic signaling pathway is greatly amplified in certain breast cancers. 7907978 Human
grb7 human breast cancers Moreover, the structure suggests the mechanism by which the Grb7 SH2 domain binds selectively to pTyr-1139 (pYVNQ) in Her2, which along with Grb7 is co-amplified in human breast cancers. 12551896 Human
grb7 gastric cancer PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer. 12739007 Human
grb7 breast cancer Our results point to the involvement of several ErbB-specific ligands (amphiregulin and neuregulin 1) and enzymes or adaptor molecules (PI3K, Src, Shc and Grb7) in the ErbB pathway dysregulation associated with breast cancer. 12866037 Human
grb7 ductal carcinoma in situ In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human
grb7 carcinoma Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. 15386389 Human
grb7 high grade intraepithelial neoplasia Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. 15386389 Human
grb7 tumor The human growth factor receptor-bound protein 7 gene (GRB7), the founding member of a family of adaptor molecules has been shown to regulate cell migration and has been implicated in tumor progression. 15386389 Human
grb7 barrett's adenocarcinoma GRB7 is localized in close proximity to the ERBB2 gene within an amplicon previously identified in Barrett's adenocarcinoma (BCA). 15386389 Human
grb7 carcinoma We evaluated gene amplification and mRNA expression of GRB7 and ERBB2 in Barrett's carcinoma and its associated precursor lesions to assess their possible role in Barrett's malignant transformation. 15386389 Human
grb7 carcinomas Copy number and expression levels were analyzed by Q-PCR (GRB7, ERBB2) and QRT-PCR (GRB7, ERBB2) using TaqMan technology and fluorescence in situ hybridization (ERBB2) in a series of 24 laser-microdissected samples of Barrett's carcinomas and 32 samp 15386389 Human
grb7 carcinomas Parallel analysis of gene copy number changes and expression levels demonstrated that GRB7 and ERBB2 displayed concomitant elevated expression levels and increased copy numbers in 32% of Barrett's carcinomas. 15386389 Human
grb7 intraepithelial neoplasia Moreover, coamplification (r(s) = 0.97, p < 0.001) and coexpression (r(s) = 0.81, p < 0.001) of GRB7 and ERBB2 are shown to be already present in a subset of BCA associated high-grade intraepithelial neoplasia (HGIN), possibly reflecting a role of a conce 15386389 Human
grb7 barrett's esophagus No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB 15386389 Human
grb7 metaplasia No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB 15386389 Human
grb7 low grade intraepithelial neoplasia No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB 15386389 Human
grb7 carcinoma No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB 15386389 Human
grb7 invasive carcinoma These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB 15386389 Human
grb7 tumor These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB 15386389 Human
grb7 high grade intraepithelial neoplasia These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB 15386389 Human
grb7 metastasis Transcripts from genes that flank ERBB2 including GRB7, a protein linked to metastasis in esophageal cancer, also showed high levels of expression. 15511476 Human
grb7 esophageal cancer Transcripts from genes that flank ERBB2 including GRB7, a protein linked to metastasis in esophageal cancer, also showed high levels of expression. 15511476 Human
grb7 chronic lymphocytic leukemia Grb7 expression and cellular migration in chronic lymphocytic leukemia: a comparative study of early and advanced stage disease. 15470489 Human
grb7 metastatic solid tumors Grb7, a noncatalytic intracellular adaptor protein involved in cell migration, is overexpressed in certain invasive and metastatic solid tumors. 15470489 Human
grb7 between chronic lymphocytic leukemia We found a highly significant difference in the level of expression of Grb7 between chronic lymphocytic leukemia (CLL) cells obtained from stage I and stage IV patients (P<0.001). 15470489 Human
grb7 cll We found a highly significant difference in the level of expression of Grb7 between chronic lymphocytic leukemia (CLL) cells obtained from stage I and stage IV patients (P<0.001). 15470489 Human
grb7 breast cancers In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20%-30% of breast cancers. 15930003 Human
grb7 metastases Grb7 binds to erbB2 and may be involved in cell signaling pathways that promote the formation of metastases and inflammatory responses. 15930003 Human
grb7 breast cancer Growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is co-overexpressed and forms a tight complex with the ErbB2 receptor in a number of breast tumours and breast cancer cell lines. 15841400 Human
grb7 breast tumours Growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is co-overexpressed and forms a tight complex with the ErbB2 receptor in a number of breast tumours and breast cancer cell lines. 15841400 Human
growth factor receptor-bound protein 7 tumor The human growth factor receptor-bound protein 7 gene (GRB7), the founding member of a family of adaptor molecules has been shown to regulate cell migration and has been implicated in tumor progression. 15386389 Human

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