IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HDAC2 Ensembl ENSG00000196591 Chromosome 6 Start 114364022 End 114399047
Description Histone deacetylase 2 (HD2)(EC 3.5.1.98) [Source:UniProtKB/Swiss-Prot;Acc:Q92769]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4853
     Entrez Gene : 3066
     UCSC : uc003pwd.1
     GeneCards : 4853
     RefSeq : NM_001527
     CCDS : CCDS43493.1
     Uniprot : Q92769
     Interpro : Q92769
     OMIM : 605164
     GeneTests : HDAC2
     CGAP : HDAC2
     PMID : 9782097

< Top >


Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 30/47(64%, AD), 9/9(100%, SCC) IHC- 14578194 Am J Pathol. 2003 Nov;163(5):1949-60.

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34368_at  0.10  3.42e-1  4.49e-1  0.78  2.34e-6  1.35e-5
 HG_U133A  201833_at  0.47  5.51e-9  1.79e-8  0.29  3.29e-3  3.62e-3
 HG_U133_Plus2  201833_at  0.54  5.85e-12  5.44e-11  0.97  2.11e-23  4.40e-22
 HG_U133_Plus2  242141_at  0.34  8.24e-4  2.18e-3  0.48  1.55e-4  3.37e-4
 Stanford  14624  0.66  1.17e-2  7.16e-2  1.15  1.06e-4  2.85e-3
 Agilent_HS_21.6K  7860  0.21  1.73e-2  6.89e-2  0.37  7.78e-6  9.14e-5

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201833_at  0.02  9.54e-1  9.98e-1  0.26  2.78e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34368_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201833_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201833_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242141_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14624    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7860    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hdac2 retinoblastoma Ebp1 bound E2F consensus oligonucleotides in association with E2F1, retinoblastoma protein, and HDAC2. 15073182 Human
hdac2 breast cancer Although most HDAC2 is not phosphorylated in the breast cancer cells, HDAC2 bound to Sp1 and Sp3 and cross-linked to chromatin in situ is highly enriched in a phosphorylated form that has a reduced mobility in SDS-polyacrylamide gels. 12176973 Human
hdac2 tumor Loss of the adenomatosis polyposis coli (APC) tumor suppressor induces HDAC2 expression depending on the Wnt pathway and c-Myc. 15144953 Human
hdac2 human colon cancer Increased HDAC2 expression is found in the majority of human colon cancer explants, as well as in intestinal mucosa and polyps of APC-deficient mice. 15144953 Human
hdac2 polyps Increased HDAC2 expression is found in the majority of human colon cancer explants, as well as in intestinal mucosa and polyps of APC-deficient mice. 15144953 Mouse
hdac2 colonic cancer HDAC2 is required for, and sufficient on its own to prevent, apoptosis of colonic cancer cells. 15144953 Human
hdac2 adenoma Interference with HDAC2 by valproic acid largely diminishes adenoma formation in APC(min) mice. 15144953 Mouse
hdac2 cancer These findings point toward HDAC2 as a particularly relevant potential target in cancer therapy. 15144953 Human
hdac2 prostate cancer When prostate cancer cell lines were treated with hypomethylating agent, 5-aza-2(')-deoxycytidine (DNMT inhibitor), HDAC1 and HDAC2 expression was decreased. 12646234 Human
hdac2 breast cancer MTA1 deregulation in breast cancer cells led to its interactions with the CAK complex components, ER, and HDAC2. 12527756 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.