IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LCP1 Ensembl ENSG00000136167 Chromosome 13 Start 45598060 End 45683484
Description Plastin-2 (L-plastin)(Lymphocyte cytosolic protein 1)(LCP-1)(LC64P) [Source:UniProtKB/Swiss-Prot;Acc:P13796]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6528
     Entrez Gene : 3936
     UCSC : uc001vba.3
     GeneCards : 6528
     RefSeq : NM_002298
     CCDS : CCDS9403.1
     Uniprot : P13796
     Interpro : P13796
     OMIM : 153430
     GeneTests : LCP1
     CGAP : LCP1
     PMID : 2111166

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37023_at  -1.19  1.40e-13  3.54e-12  -1.53  3.23e-13  7.11e-12
 HG_U133A  208885_at  -0.59  7.36e-10  2.60e-9  -4.21  2.74e-113  2.70e-112
 HG_U133_Plus2  208885_at  -0.82  2.25e-9  1.49e-8  -1.32  7.84e-14  5.37e-13
 Stanford  1340  -1.46  4.88e-4  9.06e-3  -2.33  1.51e-4  3.72e-3
 Stanford  8572  -1.52  2.65e-4  6.19e-3  -2.41  5.66e-5  1.82e-3
 Agilent_HS_21.6K  1162  -0.30  1.63e-3  1.13e-2  -0.38  1.18e-4  9.11e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208885_at  0.72  2.53e-2  6.98e-1  -0.16  5.63e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37023_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208885_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208885_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 1340    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8572    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1162    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
l-plastin cancers Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon. 12719708 Human
l-plastin cancer It has turned out to be a murine homologue of human L-plastin, which was identified as a novel protein in human cancer cells. p65/L-plastin is characterized by a series of Ca(2+)-, calmodulin-, and actin-binding domains, and is thought to play a crucial r 12843666 Human
l-plastin bladder cancer The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. 11389068 Human
l-plastin bladder cancer Infectivity and cytotoxicity experiments with the LacZ and CD vectors suggested that the L-plastin promoter-driven transcriptional units were expressed at much higher levels in explants of ovarian cancer cells from patients and in established ovarian or b 11389068 Human
l-plastin ovarian cancer Infectivity and cytotoxicity experiments with the LacZ and CD vectors suggested that the L-plastin promoter-driven transcriptional units were expressed at much higher levels in explants of ovarian cancer cells from patients and in established ovarian or b 11389068 Human
l-plastin ovarian cancer These results suggest that an adenoviral vector carrying the CD gene controlled by the L-plastin promoter (Ad-Lp-CD) may be of potential value for the i.p. therapy of ovarian cancer. 11389068 Human
l-plastin human colorectal cancer Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis. 11735128 Human
l-plastin metastasis Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis. 11735128 Human
l-plastin colorectal cancer Of these genes, we assessed the L-plastin gene, an actin-bundling protein, at the protein level using a tissue microarray consisting of 58 clinically stratified colorectal cancer specimens. 11735128 Human
l-plastin cancer Consistent with our microarray results, the expression of L-plastin was significantly correlated with the progression of cancer staging. 11735128 Human
l-plastin prostate cancer Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. 10668786 Human
l-plastin cancer L-Plastin is normally a leukocyte-specific actin-binding protein; it is also expressed in the majority of human cancer cell lines that are derived from many types of solid tumors. 10668786 Human
l-plastin breast cancer We now obtained evidence that L-plastin gene expression was positively regulated by testosterone in androgen receptor (AR)-positive prostate and breast cancer cells. 10668786 Human
l-plastin prostate cancer In PC-3 prostate cancer cells, cooperation among L-plastin AREs was still evident although individually they had moderate levels of testosterone/AR responsiveness. 10668786 Human
l-plastin tumor No correlation between L-plastin expression and tumor size, histological grade or lymph node status was observed. 11062740 Human
l-plastin negative tumors In contrast, L-plastin was found expressed in 4 of the 11 estrogen and progesterone receptors negative tumors (p = 0.039). 11062740 Human
l-plastin ovarian cancer Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells. 10195877 Human
l-plastin human tumors The leukocyte isoform l-plastin is expressed in a diverse variety of human tumor cell lines, suggesting that it may be involved in the neoplastic process of some solid human tumors. 3211125 Human
l-plastin human tumor The leukocyte isoform l-plastin is expressed in a diverse variety of human tumor cell lines, suggesting that it may be involved in the neoplastic process of some solid human tumors. 3211125 Human
l-plastin prostate carcinoma Suppression of prostate carcinoma cell invasion by expression of antisense L-plastin gene. 10393844 Human
l-plastin prostate carcinoma Based on the finding that gene expression for the actin-bundling protein L-plastin is inducible by androgen and that L-plastin is overexpressed in malignant epithelium of the prostate, we examined the functional consequences of L-plastin down-regulation i 10393844 Human
l-plastin metastasis These results suggested that overexpression of L-plastin might be functionally involved in prostate cancer invasion and metastasis, and raised the possibility that L-plastin gene-specific antisense delivery could potentially be a useful approach to interf 10393844 Human
l-plastin prostate cancer These results suggested that overexpression of L-plastin might be functionally involved in prostate cancer invasion and metastasis, and raised the possibility that L-plastin gene-specific antisense delivery could potentially be a useful approach to interf 10393844 Human
l-plastin b lymphoma Synthetic 18-mer l-plastin 588-605 peptide (SMARKIGARVYALPEDLV, as described by the amino acid single letter code) was demonstrated to bind to Abetaz/Aalphad MHC class II molecules on transfectant B lymphoma cells (TAbetaz). 9893048 Human
l-plastin human prostate carcinoma Application of differential display to the comparison of androgen-stimulated and unstimulated human prostate carcinoma cell line LNCaP identified androgen induction of the L-plastin gene, which encodes an actin-binding protein isoform. 9176394 Human
l-plastin prostate carcinoma L-plastin expression is also detected in other prostate carcinoma cell lines by reverse transcriptase polymerase chain reaction and immunohistochemistry but not in the single normal adult prostate epithelial cell line that is available to us. 9176394 Human
l-plastin carcinomas Taken together, these results suggest that the expression of L-plastin in prostatic epithelial cells is linked to the malignant state and that, once expressed in carcinomas, its expression is regulated by steroid hormone receptors. 9176394 Human
l-plastin tumor Characterization of the M(r) 65,000 lymphokine-activated killer proteins phosphorylated after tumor target binding: evidence that pp65a and pp65b are phosphorylated forms of L-plastin. 8548753 Human
l-plastin tumor On the basis of known properties of phosphorylated L-plastin, it is hypothesized that p65 phosphorylation in LAKs may regulate adhesion to tumor targets. 8548753 Human
lcp1 retinoblastoma A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13. 3864729 Human
lcp1 retinoblastoma This finding also suggests that the LCP1 locus is linked to the retinoblastoma gene, which is assigned to the same chromosomal region and closely linked to the ESD locus. 4083280 Human
l-plastin solid tumors Previous studies indicated that, among normal cells, only those of hemopoietic lineages expressed the abundant leukocyte phosphoprotein, L-plastin, and that activation of the L-plastin gene frequently occurred in malignant cells of solid tumors. 8012965 Human
l-plastin sarcoma A survey of SV40-transformed human fibroblasts and human sarcoma and carcinoma cell types demonstrated that the L-plastin gene was activated at widely varying degrees in nearly all human cancer cells. 8055865 Human
l-plastin carcinoma A survey of SV40-transformed human fibroblasts and human sarcoma and carcinoma cell types demonstrated that the L-plastin gene was activated at widely varying degrees in nearly all human cancer cells. 8055865 Human
l-plastin cancer A survey of SV40-transformed human fibroblasts and human sarcoma and carcinoma cell types demonstrated that the L-plastin gene was activated at widely varying degrees in nearly all human cancer cells. 8055865 Human
l-plastin tumor However, L-plastin has been also found in tumor cells of non-hematopoietic origin (Lin, C.-S., R. H. Aebersold, S. B. Kent, M. Varma, and J. Leavitt. 1988. Mol. Cell. Biol. 8:4659-4668; Lin, C.-S., R. H. Aebersold, and J. Leavitt. 1990. Mol. Cell. Biol. 1 7806577 Human
l-plastin carcinomas An expanded survey of normal cell types and 50 tumor cell lines, demonstrated that 68% of carcinomas and 53% of other solid tumors of nonepithelial origin exhibited L-plastin expression, whereas the normal stem cell progenitors did not. 8428952 Human
l-plastin tumor An expanded survey of normal cell types and 50 tumor cell lines, demonstrated that 68% of carcinomas and 53% of other solid tumors of nonepithelial origin exhibited L-plastin expression, whereas the normal stem cell progenitors did not. 8428952 Human
l-plastin other solid tumors An expanded survey of normal cell types and 50 tumor cell lines, demonstrated that 68% of carcinomas and 53% of other solid tumors of nonepithelial origin exhibited L-plastin expression, whereas the normal stem cell progenitors did not. 8428952 Human
l-plastin ovarian carcinomas Fibrosarcomas (n = 4), ovarian carcinomas (n = 9), breast carcinomas (n = 4), and choriocarcinomas (n = 2) combined exhibited the highest frequency and levels of L-plastin expression (95% frequency). 8428952 Human
l-plastin breast carcinomas Fibrosarcomas (n = 4), ovarian carcinomas (n = 9), breast carcinomas (n = 4), and choriocarcinomas (n = 2) combined exhibited the highest frequency and levels of L-plastin expression (95% frequency). 8428952 Human
l-plastin cancers The frequency of L-plastin induction in some cancers of the steroid-regulated female reproductive tract (breast, ovary, uterus, and placenta) appears to be especially high (79% in a limited survey). 8428953 Human
l-plastin tumor The utility of this recombinant promoter in determining the mechanism(s) that leads to activation of the L-plastin gene in tumor cells is discussed. 8428953 Human
l-plastin cancers The potential significance of regulation of the L-plastin gene by reproductive hormones in cancers arising in hormone-responsive tissues is also discussed. 8428953 Human
l-plastin solid tumors The amino acid sequences of four peptidic fragments, obtained from the purified protein by enzymatic or chemical cleavage, were completely or nearly identical to those of L-plastin, a protein initially identified in transformed cells from solid tumors (Go 8461306 Human
l-plastin fibrosarcomas Fibrosarcomas (n = 4), ovarian carcinomas (n = 9), breast carcinomas (n = 4), and choriocarcinomas (n = 2) combined exhibited the highest frequency and levels of L-plastin expression (95% frequency). 8428952 Human
l-plastin choriocarcinomas Fibrosarcomas (n = 4), ovarian carcinomas (n = 9), breast carcinomas (n = 4), and choriocarcinomas (n = 2) combined exhibited the highest frequency and levels of L-plastin expression (95% frequency). 8428952 Human
l-plastin solid tumors L-Plastin is normally a leukocyte-specific actin-binding protein; it is also expressed in the majority of human cancer cell lines that are derived from many types of solid tumors. 10668786 Human
l-plastin cancers of the breast Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon. 12719708 Human
l-plastin tumor T- and L-plastin are highly similar actin-bundling proteins implicated in the regulation of cell morphology, lamellipodium protrusion, bacterial invasion and tumor progression. 15752138 Human
l-plastin cancer Finally, both T- and L-plastin are implicated in several diseases, and L-plastin is considered to be a valuable marker for cancer. 15960882 Human
lcp1 rb These data indicate that the gene for LCP1 (LCP1) is located in the region q14.1-q32 of chromosome 13 and may be a useful genetic marker for preclinical diagnosis of Rb. 3864729 Human

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