IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LPL Ensembl ENSG00000175445 Chromosome 8 Start 19840870 End 19869050
Description Lipoprotein lipase Precursor (LPL)(EC 3.1.1.34) [Source:UniProtKB/Swiss-Prot;Acc:P06858]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 6677
     Entrez Gene : 4023
     UCSC : uc003wzk.3
     GeneCards : 6677
     RefSeq : NM_000237
     CCDS : CCDS6012.1
     Uniprot : P06858
     Interpro : P06858
     OMIM : 609708
     GeneTests : LPL
     CGAP : LPL

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41209_at  -2.11  3.29e-18  1.72e-16  -2.78  1.59e-25  6.91e-23
 HG_U133A  203548_s_at  -2.57  1.27e-28  1.80e-27  -1.37  2.22e-32  3.85e-32
 HG_U133A  203549_s_at  -2.19  1.32e-48  6.00e-47  -1.28  1.03e-48  2.30e-48
 HG_U133_Plus2  203548_s_at  -2.76  2.83e-22  8.41e-21  -4.16  6.98e-31  3.57e-29
 HG_U133_Plus2  203549_s_at  -2.56  1.16e-33  1.21e-31  -3.29  1.07e-42  3.45e-40
 Stanford  7061  -3.27  3.77e-8  1.34e-5  -4.27  2.16e-7  3.45e-5
 Stanford  8189  -2.71  3.70e-7  6.87e-5  -3.81  1.18e-8  4.82e-6
 Agilent_HS_21.6K  14528  -1.01  6.52e-7  1.70e-5  -1.33  3.16e-10  1.54e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203548_s_at  0.34  6.89e-1  9.67e-1  -0.30  5.87e-1  1.00e+0
 HG_U133A  203549_s_at  0.16  6.85e-1  9.67e-1  0.06  7.98e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41209_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203548_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203549_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203548_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203549_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7061    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8189    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14528    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lpl cll CONCLUSIONS: LPL mRNA expression is a valuable prognostic marker in CLL. 17158192 Human
lpl prostate cancer Loss of a part of chromosome 8p22, containing the gene LPL and amplifications of the field 8q24 comprising the c-myc oncogene are the most frequent chromosomal aberrations in prostate cancer. 17319789 Human
lipoprotein lipase b cell chronic lymphocytic leukemia Lipoprotein lipase mRNA expression in whole blood is a prognostic marker in B cell chronic lymphocytic leukemia. 17158192 Human
lpl tumourbearing Administration of phentolamine (an alpha-adrenergic antagonist) to tumour-bearing rats did not influence LPL activity, but it reversed the increase in plasma triglycerides associated with tumour burden. 9018104 Rat
lpl tumors FISH analysis using paraffin-embedded tissues was performed for 8p22 (LPL), centromere 8 (8cen), and 8q24 (MYC) and was successful for 156 tumors (80.0%). 12112525 Human
lipoprotein lipase prostate cancer Furthermore, cDNA microarray analysis indicates that the expression of lipoprotein lipase, a gene frequently deleted in prostate cancer, is down-regulated in a cell line that expresses PAGE4. 12489849 Human
lpl xanthoma INTRODUCTION: Familial lipoprotein lipase (LPL) deficiency is inherited as an autosomal recessive trait and is characterized by chylomicronemia, eruptive xanthoma, hepatosplenomegaly, and recurrent pancreatitis. 12883259 Human
lipoprotein lipase xanthoma INTRODUCTION: Familial lipoprotein lipase (LPL) deficiency is inherited as an autosomal recessive trait and is characterized by chylomicronemia, eruptive xanthoma, hepatosplenomegaly, and recurrent pancreatitis. 12883259 Human
lipoprotein lipase human lung cancer Lipolytic and lipoprotein lipase (LPL)-inhibiting activities produced by a human lung cancer cell line responsible for cachexia induction. 11848498 Human
lipoprotein lipase cancer With the aim of identifying novel molecules involved in lipid catabolism, conditioned media of these cancer cell lines were analyzed in terms of lipoprotein lipase (LPL)-inhibiting or lipolytic activities. 11848498 Human
lpl hyperplasia Changes in LPL activity, lipogenesis and lipolysis contribute to the sequential steps of adipocyte hyperplasia and hypertrophia occurring during the extra-uterine white adipose tissue development in rat, and this may be used as a model to extrapolate the 10867720 Human
lpl breast cancer We previously reported that tamoxifen decreases the activity of lipoprotein lipase (LPL), a key enzyme in triglyceride metabolism, in patients with breast cancer. 10965219 Human
lipoprotein lipase breast cancer We previously reported that tamoxifen decreases the activity of lipoprotein lipase (LPL), a key enzyme in triglyceride metabolism, in patients with breast cancer. 10965219 Human
lpl cancer Several lines of evidence have postulated that reduction in the activity of lipoprotein lipase (LPL) is involved in cachexia induction in cancer patients. 11062730 Human
lipoprotein lipase cancer Several lines of evidence have postulated that reduction in the activity of lipoprotein lipase (LPL) is involved in cachexia induction in cancer patients. 11062730 Human
lpl melanoma Recently we have demonstrated that murine melanoma B16 has the ability to reduce the LPL activity and thereby induce cachexia symptoms in mice following intraperitoneal inoculation. 11062730 Mouse
lpl melanoma In order to further investigate the relationship between LPL activity and cachectic syndrome, cachexia models other than melanoma B16 are required. 11062730 Human
lpl mouse lymphoma In this study, cachectic symptoms and plasma LPL activity were investigated in mice bearing EL-4 mouse lymphoma. 11062730 Human
lpl cancer Overall, this study indicated that EL-4 lymphoma in mice results in a severe cachexia which is possibly related to impaired LPL activity and also provided a useful cachexia model for understanding the role of LPL in the development of cancer cachexia. 11062730 Mouse
lipoprotein lipase tumors When compared with controls or nonresponding tumors, the expression of adipocyte-related genes such as adipocyte P2 (aP2), adipsin, peroxisome proliferator-activated receptor gamma (PPARgamma), and lipoprotein lipase was elevated in LGD1069-responding tum 11085524 Human
lpl b16 melanoma Our recent study has demonstrated that ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice. 10628359 Mouse
lipoprotein lipase b16 melanoma Our recent study has demonstrated that ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice. 10628359 Mouse
lpl melanomas In this study, the effect of ponalrestat on cachexia symptoms in nude mice bearing human melanomas G361 and SEKI was investigated because it has been suggested that the suppression of LPL has an important role in cachexia induction by these two melanomas 10628359 Mouse
lpl b16 melanoma Overall, this study demonstrated that cachexia induced by B16 melanoma in mice was alleviated by the LPL activators bezafibrate and NO-1886, suggesting the involvement of the impaired LPL activity in the establishment of cachexia syndrome in mice bearing 10628360 Mouse
lpl cancer The reduction in LPL activity is observed in tumor bearing animals and cancer patients with cachectic symptoms, suggesting an involvement of LPL in inducing cancer cachexia. 10226565 Human
lpl tumor The reduction in LPL activity is observed in tumor bearing animals and cancer patients with cachectic symptoms, suggesting an involvement of LPL in inducing cancer cachexia. 10226565 Human
lpl b16 melanoma Overall, this study demonstrated that ponalrestat, an aldose reductase inhibitor, possesses potent LPL activating activity and that the cachexia induced by B16 melanoma was alleviated by treatment with 'ponalrestat, suggesting that ponalrestat, a LPL 10226565 Human
lpl cancer Overall, this study demonstrated that ponalrestat, an aldose reductase inhibitor, possesses potent LPL activating activity and that the cachexia induced by B16 melanoma was alleviated by treatment with 'ponalrestat, suggesting that ponalrestat, a LPL 10226565 Human
lpl gastrointestinal cancers METHODOLOGY: Three pacemaker enzymes; phosphoenolpyruvate carboxykinase (PEPck) for gluconeogenesis, malic enzyme for de novo fatty acid synthesis, and lipoprotein lipase (LPL) for triglyceride clearance in liver and adipose tissues were examined in 22 pa 10228861 Human
lipoprotein lipase gastrointestinal cancers METHODOLOGY: Three pacemaker enzymes; phosphoenolpyruvate carboxykinase (PEPck) for gluconeogenesis, malic enzyme for de novo fatty acid synthesis, and lipoprotein lipase (LPL) for triglyceride clearance in liver and adipose tissues were examined in 22 pa 10228861 Human
lpl tumor LPL activity in the abdominal subcutaneous tissue was increased by advanced tumor bearing (p < 0.05). 10228861 Human
lpl cancer Pre-operative total parenteral nutrition for 1 week resulted in significant stimulation of LPL activity in adipose tissue from patients with advanced cancer compared to that from controls (6.53 +/- 4.99 U/g tissue and 1.32 +/- 0.18 U/g tissue, respectivel 10228861 Human
lpl primary carcinomas Fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, and 17 and region-specific probes for D7S486 (7q31), c-myc (8q24), LPL (8p22), and p53 (17p13) was performed on available primary carcinomas and lymph node met 11796839 Human
lpl lymph-node metastases Fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, and 17 and region-specific probes for D7S486 (7q31), c-myc (8q24), LPL (8p22), and p53 (17p13) was performed on available primary carcinomas and lymph node met 11796839 Human
lpl other cancer The LPL region has been extensively studied in NSCLC and other cancer types. 10362129 Human
lipoprotein lipase hyperplasia A novel compound, NO-1886, which possesses a powerful lipoprotein lipase activity-increasing action, induces hypertrophy of adrenals in rats and hyperplasia of cortical cells in dogs. 10443901 Dog
lpl rat insulinoma LPL message was detected in mouse islets, INS-1 cells (a rat insulinoma cell line), and human islets. 10488074 Rat
lipoprotein lipase tumor METHODS: We used dual-probe fluorescence in situ hybridization and DNA probes for 8p22 (lipoprotein lipase gene), centromere 8 (8cen), and 8q24 (c-myc gene) to determine the corresponding copy numbers in tumor samples from 144 patients with high-grade, ad 10491435 Human
lipoprotein lipase prostate carcinoma METHODS: We used dual-probe fluorescence in situ hybridization and DNA probes for 8p22 (lipoprotein lipase gene), centromere 8 (8cen), and 8q24 (c-myc gene) to determine the corresponding copy numbers in tumor samples from 144 patients with high-grade, ad 10491435 Human
lipoprotein-lipase xanthomas METHODS: Two siblings with familial lipoprotein-lipase deficiency and subsequent hyperchylomicronemia, widespread skin xanthomas and severe insulin-resistant diabetes mellitus came to our observation after several unsuccessful attempts at medical treatmen 9730393 Human
lipoprotein-lipase multiple symmetric lipomatosis (msl) We have evaluated the relationships between adipose tissue lipoprotein-lipase activity (AT-LPL) or post-heparin plasma lipolytic activity (PHLA) and the composition of circulating lipoproteins in 7 patients with multiple symmetric lipomatosis (MSL). 4066122 Human
lpl tumourbearing These changes in lipaemia were associated with a marked decrease in LPL activity in white adipose tissue; in contrast, LPL activity was increased in the tumour-bearing animals in brown adipose tissue at day 6 following inoculation and in the heart during 9215859 Rat
lpl advanced cancer Pre-operative total parenteral nutrition for 1 week resulted in significant stimulation of LPL activity in adipose tissue from patients with advanced cancer compared to that from controls (6.53 +/- 4.99 U/g tissue and 1.32 +/- 0.18 U/g tissue, respectivel 10228861 Human
lpl nsclc The LPL region has been extensively studied in NSCLC and other cancer types. 10362129 Human
lpl necrosis Lipoprotein lipase (LPL) activity in the retroperitoneal adipose tissue of a patient with Cushing's syndrome and in the subcutaneous adipose tissue of a patient with aseptic necrosis of the femoral head was higher than that in the corresponding tissu 11223423 Human
lpl nsclc Although FEZ1 expression was moderately correlated with loss of heterozygosity of specific microsatellite makers at 8p21-22 in NSCLC cell lines, it was strongly correlated to D8S261 and LPL loci in SCLC cell lines. 12114433 Human
lpl prostate cancer A high fat intake has been associated with prostate cancer risk, and gene polymorphisms of lipoprotein lipase (LPL) play an important role in plasma lipoprotein metabolism. 15386377 Human
lpl prostate cancer We herein analyzed the association of LPL gene polymorphisms with the risk of prostate cancer in a Japanese population. 15386377 Human
lpl prostate cancer Three single nucleotide polymorphisms (SNPs) of LPL designated as Ser447stop, HindIII and PvuII were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method in 273 prostate cancer patients, 205 benign prostatic hyperplas 15386377 Human
lpl prostate cancer Our results suggest that the LPL Ser447stop polymorphism is a common genetic modifier for the development of prostate cancer, particularly that of high-grade and/or high-stage, in a Japanese population. 15386377 Human
lpl colon cancer These results indicate that suppression of serum lipid levels by increasing LPL activity may contribute to a reduction of intestinal polyp formation with Apc-deficiency, and NO-1886 and its derivatives could be useful as chemopreventive agents for colon c 15710887 Mouse
lpl chronic lymphocytic leukemia The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. 15802535 Human
lpl cll Although the zeta-associated protein of 70 kDa (ZAP-70) is overexpressed in patients with chronic lymphocytic leukemia (CLL) displaying unmutated IGVH genes and poor prognosis, a previous microarray study from our group identified overexpression of LPL an 15802535 Human
lpl cll Overall, quantification of LPL and ADAM29 gene expression is a strong prognostic indicator in CLL, providing better prognostic assessment than ZAP-70 in advanced stages of the disease. 15802535 Human
lpl cll LPL mRNA levels in peripheral blood mononuclear cells (PBMNC) from 104 CLL patients differed by 1.5 orders of magnitude between cases with mutated (N=51) or unmutated (N=53) IGV(H) (median: 1.33 vs 45.22 compared to normal PBMNC). 15858619 Human
lipoprotein lipase b-cell chronic lymphocytic leukemia (b-cll) We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. 15858619 Human
lipoprotein lipase cancers [Reduced plasma lipoprotein lipase activity in patients with various cancers: preliminary report] 8177206 Human
lipoprotein lipase early-onset breast cancer The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic sho 16121806 Human
lipoprotein-lipase pancreatic carcinomas [Elective induction in mice of solid and ascitic carcinoma of the exocrine pancreas by the repeated doses of antibodies against a lipoprotein lipase fraction] Small doses, repeated for months of anti-esterase-lipoprotein antibodies, from several antisera 403027 Mouse
lipoprotein lipase xanthomas [Primary lipoprotein lipase deficiency: clinical and genetic aspects] Primary deficiency of the enzyme lipoprotein lipase (LPL) is an autosomal recessive disorder characterized by chylomicronemia, recurrent pancreatitis and xanthomas. 7853714 Human
lipoprotein lipase xanthomas The screening of lipoprotein lipase gene mutations should be carried out in all families with hyperchylomicronemia, regardless of the presence or absence of xanthomas. 11908140 Human
lipoprotein lipase necrosis The membrane enzymes lipoprotein lipase and Ca-ATPase decreased due to myocardial necrosis. 2722218 Rat
lipoprotein lipase necrosis Lipoprotein lipase activity of post-heparin plasma in Japanese black cattle affected with fat necrosis. 8762610 Cow
lipoprotein lipase necrosis Post-heparin plasma (PHP) lipoprotein lipase (LPL) activity and serum lipoprotein concentration were examined in Japanese Black cows affected with fat necrosis. 8762610 Cow
lipoprotein lipase necrosis Lipoprotein lipase (LPL) activity in the retroperitoneal adipose tissue of a patient with Cushing's syndrome and in the subcutaneous adipose tissue of a patient with aseptic necrosis of the femoral head was higher than that in the corresponding tissu 11223423 Human
lipoprotein lipase papillary serous carcinoma of the peritoneum The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic sho 16121806 Human
lipoprotein lipase human osteosarcoma Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. 8670156 Human
lipoprotein lipase human osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lipoprotein lipase hyperplasia Little change was observed in levels of transcripts involved in de novo fatty acid synthesis, beta-oxidation, lipolysis, differentiation and cholesterol metabolism, suggesting that cholesterol feeding prevents hyperplasia and hypertrophy of ArKO adipocyte 15702435 Mouse
lipoprotein lipase stomach cancer [Blood lipase activity in cancer patients] Blood plasma lipoprotein lipase level was measured in lung and stomach cancer patients before surgery and during postoperative period. 2773395 Human
lipoprotein lipase hepatoma The level of adipose tissue lipoprotein lipase was decreased by hepatoma implantation and LPS injection, while the hormone-sensitive lipase activity was increased by the same treatments. 14745166 Rat
lipoprotein lipase b-cell chronic lymphocytic leukemia High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. 15858619 Human
lipoprotein lipase adrenal hyperplasia [The human genome--chromosome 8] From hitherto identified genes located on the 8th human chromosome the author mentions the following: the lipoprotein lipase gene the pathogenic allells of which cause hyperlipoproteinaemia, the ancyrine gene responsible f 7758082 Human
lipoprotein lipase cancer [Stimulation of tissue lipoprotein lipase activity in cancer cachectic rats: preliminary report] 8361478 Rat
lipoprotein lipase cancer Levels of mRNA for HSL are elevated twofold in adipose tissue of cancer patients, while there are no changes in lipoprotein lipase (LPL), involved in extraction of fatty acids from plasma lipoproteins for storage. 15168125 Human
lipoprotein lipase hemangioblastoma The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic sho 16121806 Human
lipoprotein lipase hyperplastic Normal adiposity in lipoprotein lipase deficiency can thus be attributed to mature adipocytes and not to hyperplastic growth of immature fat cells. 1330953 Human
lipoprotein lipase intestinal polyp Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. 15710887 Mouse
lipoprotein lipase intestinal polyp We have previously reported a hyperlipidemic state in two strains of Apc-deficient mice, Min and Apc(1309), associated with low expression levels of lipoprotein lipase (LPL) in the liver and small intestine, and enforced induction of LPL mRNA by peroxisom 15710887 Mouse
lpl cancer Induction of lipolysis by the cytokines is thought to result from an inhibition of lipoprotein lipase (LPL), although clinical studies provide no evidence for an inhibition of LPL in the adipose tissue of cancer patients. 9915907 Human
lpl human lung cancer Lipolytic and lipoprotein lipase (LPL)-inhibiting activities produced by a human lung cancer cell line responsible for cachexia induction. 11848498 Human
lpl sclc Although FEZ1 expression was moderately correlated with loss of heterozygosity of specific microsatellite makers at 8p21-22 in NSCLC cell lines, it was strongly correlated to D8S261 and LPL loci in SCLC cell lines. 12114433 Human
lpl cancer Levels of mRNA for HSL are elevated twofold in adipose tissue of cancer patients, while there are no changes in lipoprotein lipase (LPL), involved in extraction of fatty acids from plasma lipoproteins for storage. 15168125 Human
lpl benign prostatic hyperplasia (bph) Three single nucleotide polymorphisms (SNPs) of LPL designated as Ser447stop, HindIII and PvuII were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method in 273 prostate cancer patients, 205 benign prostatic hyperplas 15386377 Human
lpl chronic lymphocytic leukemia (cll) Although the zeta-associated protein of 70 kDa (ZAP-70) is overexpressed in patients with chronic lymphocytic leukemia (CLL) displaying unmutated IGVH genes and poor prognosis, a previous microarray study from our group identified overexpression of LPL an 15802535 Human
lpl b-cell chronic lymphocytic leukemia (b-cll) We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. 15858619 Human
lipoprotein lipase cancer Induction of lipolysis by the cytokines is thought to result from an inhibition of lipoprotein lipase (LPL), although clinical studies provide no evidence for an inhibition of LPL in the adipose tissue of cancer patients. 9915907 Human
lipoprotein lipase carcinoma [Elective induction in mice of solid and ascitic carcinoma of the exocrine pancreas by the repeated doses of antibodies against a lipoprotein lipase fraction] Small doses, repeated for months of anti-esterase-lipoprotein antibodies, from several antisera 403027 Mouse
lpl lymph node metastases Fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, and 17 and region-specific probes for D7S486 (7q31), c-myc (8q24), LPL (8p22), and p53 (17p13) was performed on available primary carcinomas and lymph node met 11796839 Human
lpl intestinal polyp We have previously reported a hyperlipidemic state in two strains of Apc-deficient mice, Min and Apc(1309), associated with low expression levels of lipoprotein lipase (LPL) in the liver and small intestine, and enforced induction of LPL mRNA by peroxisom 15710887 Mouse
lpl intestinal polyp These results indicate that suppression of serum lipid levels by increasing LPL activity may contribute to a reduction of intestinal polyp formation with Apc-deficiency, and NO-1886 and its derivatives could be useful as chemopreventive agents for colon c 15710887 Mouse
lipoprotein lipase prostate cancer Association of lipoprotein lipase gene polymorphism with risk of prostate cancer in a Japanese population. 15386377 Human
lipoprotein lipase prostate cancer A high fat intake has been associated with prostate cancer risk, and gene polymorphisms of lipoprotein lipase (LPL) play an important role in plasma lipoprotein metabolism. 15386377 Human
lpl localized prostate cancer Fluorescence in situ hybridization analysis for evaluation of 7, 8, X chromosomes and EGFR, LPL, MYC, AR genes in 79 neoplastic foci from 56 patients with clinically localized prostate cancer was performed. 16002207 Human
lpl cll INTERPRETATION AND CONCLUSIONS: This study demonstrates that LPL expression is a predictor for survival in CLL, and for this purpose is as good as IGVH mutational status and more reliable than ZAP70 expression when tested in unpurified CLL samples. 16434371 Human
lpl b-cell chronic lymphocytic leukemia (b-cll) Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. 16617321 Human
lpl breast cancer We found that breast cancer cells do not express lipoprotein lipase (LPL) and hypothesize that they do not have access to circulating lipids unless the local environment supplies it. 16809441 Human
lpl metastases This may explain why primary breast cancers with low S14 do not survive transit from the LPL-rich mammary fat pad to areas devoid of LPL, such as lymph nodes, and thus do not appear as distant metastases. 16809441 Human
lpl primary breast cancers This may explain why primary breast cancers with low S14 do not survive transit from the LPL-rich mammary fat pad to areas devoid of LPL, such as lymph nodes, and thus do not appear as distant metastases. 16809441 Human
lipoprotein lipase chronic lymphocytic leukemia The predictive value of lipoprotein lipase for survival in chronic lymphocytic leukemia. 16434371 Human
lipoprotein lipase b-cell chronic lymphocytic leukemia Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression. 16617321 Human
lipoprotein lipase b-cell chronic lymphocytic leukemia (b-cll) Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. 16617321 Human
lipoprotein lipase mammary carcinoma In mammary carcinoma bearing animals, the activities of total lipase, cholesterol ester synthase, and cholesterol ester hydrolase were significantly (p < 0.05) increased whereas lipoprotein lipase and lecithin cholesterol-acyl transferase were decreased. 16626674 Rat
lipoprotein lipase breast cancer We found that breast cancer cells do not express lipoprotein lipase (LPL) and hypothesize that they do not have access to circulating lipids unless the local environment supplies it. 16809441 Human
lipoprotein lipase b-cell chronic lymphocytic leukemia Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia. 16840197 Human
lpl intestinal polyp Moreover, treatment with a peroxisome proliferator-activated receptor (PPAR) alpha agonist, bezafibrate, or a PPARgamma agonist, pioglitazone, suppressed both hyperlipidemia and intestinal polyp formation in the mice, with induction of LPL mRNA. 16606335 Mouse
lpl intestinal polyp When given at 400 or 800 ppm in the diet, it suppresses both hyperlipidemia and intestinal polyp formation in Apc-deficient mice, with elevation of LPL mRNA. 16606335 Mouse
lpl intestinal polyp In conclusion, a decrease in serum lipid levels by increasing LPL activity may contribute to a reduction in intestinal polyp formation with Apc deficiency. 16606335 Mouse
lipoprotein lipase intestinal polyp Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice. 16606335 Mouse
lipoprotein lipase diamond blackfan anemia The 20 genes with at least a 3-fold change, annotated with known phenotypic associations in the current gene databank (phenotype association, fold change) were aspartoacylase (Canavan disease, 9.96), growth hormone receptor (Laron dwarfism, idiopathic sho 16121806 Human
lpl cell hyperplasia The higher LPL activity in fat birds resulted mainly from cell hyperplasia, rather than from a greater intrinsic activity of adipocytes. 2685199 Chicken
lpl cancer The findings that MLPLI inhibits LPL activity and that MLPLI is produced by human cancer cells inducing cancer cachexia also suggest that this protein is a candidate for the factor responsible for cancer cachexia. 2730639 Human
lpl monocytic leukemia Lipoprotein lipase (LPL) mRNA levels are under the control of signals that activate phospholipase C, resulting in activation of protein kinase C (PKC) and mobilization of intracellular Ca2+ in the human monocytic leukemia cell line THP-1. 2765502 Human
lpl tumor The regulation of secretion of lipoprotein lipase (LPL) was studied in in vitro-derived mouse bone marrow macrophages (BMM), peritoneal exudate and resident macrophages and in the macrophage-like tumor cell line J774.1. 2917136 Mouse
lpl cancers The total post-heparin lipolytic activity (PHLA) and hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) activities in post-heparin plasma of patients with various cancers were measured. 2987072 Human
lpl cancers In patients with cancers, PHLA was similar to that of controls, but the HTGL activity was decreased and the LPL activity was increased. 2987072 Human
lpl cancer Thus, in cancer patients the ratios of HTGL to PHLA were lower, and the ratios of LPL to PHLA were higher than in controls. 2987072 Human
lpl endometrial cancer The effect of high dose medroxyprogesterone acetate (MPA) on serum lipids, on adipose tissue lipoprotein lipase (LPL) and serum lecithin cholesterol acyltransferase activities were studied in 15 postmenopausal patients with endometrial cancer. 3155702 Human
lpl craniopharyngioma The activity of lipoprotein lipase (LPL) was measured in adipose tissue (AT-LPL) and postheparin plasma (PH-LPL) of 13 obese patients (aged 11 to 31 years) who had surgery for craniopharyngioma 1 to 13 years earlier. 3285130 Human
lpl cancer TNF may not cause the cachexia of cancer or chronic infection by directly inhibiting LPL in adipose tissue. 3411249 Human
lpl tumor LPS suppressed in a dose- and time-dependent manner the heparin-induced secretion of LPL from the macrophage-like tumor cell line J774.1 and from bone marrow derived mononuclear phagocytes (BMM). 3499389 Human
lpl cancer We conclude that the significant decrease in the total LPL activity may be responsible in part for the characteristic hypertriglyceridemia present in cancer patients. 3781475 Human
lpl hyperplasia The induction of a hypothyroid state resulted in thyroid hyperplasia, with decreased thyroid iodine content, altered serum thyroid relating hormone levels (increased TSH and decreased T3 and T4), elevated serum total cholesterol and reduced serum triacylg 4078646 Rat
lpl tumor These results suggest that a defect in clearance, due to the decrease in the activity of adipose tissue LPL, may be responsible for the early development of hypertriglyceridemia during tumor growth. 6386147 Rat
lpl tumor In this study, the alterations in the lipogenic enzymes and LPL cannot be attributed to reduced food intake but may be due to the direct or an indirect effect of the tumor on a hormone such as insulin. 6386147 Rat
lpl prolactinoma Oral glucose tolerance tests (OGTT) were performed and postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities were determined in twelve patients before and after transsphenoidal removal of the prolactinoma. 7047001 Human
lpl prolactinoma Conclusion: prolactinoma is associated with metabolic abnormalities characterized by hyperlipidaemia, low plasma LPL activity and insulin resistance. 7047001 Human
lpl myeloma VLDL from relatives with hypertriglyceridaemia, but without myeloma, had normal apolipoprotein content, activated LPL, and were efficient substrates for the enzyme. 7056035 Human
lpl tumor Elevated TG concentration in the serum of tumor-bearing hamsters was more remarkable and preceded the increase in other lipids, whereas the activity of LPL, the key enzyme of TG metabolism in vivo, was drastically reduced. 7560416 others
lpl tumor Therefore, the presence of TNF-alpha might lead to the increase in plasma TG mediated by LPL in tumor-bearing hamsters. 7560416 others
lpl xanthomas Humans with complete defects in LPL activity present from infancy with failure to thrive, eruptive xanthomas, pancreatitis, and lactescent plasma. 7578404 Human
lpl cancer Tumor cell products with activity to inhibit lipoprotein lipase (LPL) were shown to play an important role in the development of the cancer cachexia syndrome. 7622421 Human
lpl fibrosarcoma We compared the effects of 0.45% normal saline (NS), 5% Intralipid (IL), and 16.7% glucose (Glu) infusions on total serum triglycerides and cholesterol, serum high-(HDL-c) and low-density lipoprotein cholesterol (LDL-c), and activity of serum lecithin:cho 7698286 Human
lpl tumor In tumor-bearing rats administered IL, a two-fold increase in total serum triglyceride and cholesterol, a three-fold increase in HDL-c and HDL-c/LDL-c ratio, and a two-fold increase in LPL activity were observed compared to tumor-bearing rats administered 7698286 Rat
lpl prostatic carcinomas Polymorphic alleles at loci such as LPL (lipoprotein lipase) and MSR (macrophage scavenger receptor) in chromosome band 8p22 are frequently lost during the genesis of several types of human cancer, including colorectal, non-small cell lung, hepatocellular 7698754 Human
lpl cancer Polymorphic alleles at loci such as LPL (lipoprotein lipase) and MSR (macrophage scavenger receptor) in chromosome band 8p22 are frequently lost during the genesis of several types of human cancer, including colorectal, non-small cell lung, hepatocellular 7698754 Human
lpl xanthomas [Primary lipoprotein lipase deficiency: clinical and genetic aspects] Primary deficiency of the enzyme lipoprotein lipase (LPL) is an autosomal recessive disorder characterized by chylomicronemia, recurrent pancreatitis and xanthomas. 7853714 Human
lpl tumors Thus, LPL accounts for most of the lipolytic activity in extracts of acetone/ether powders of the tumors. 7912239 Human
lpl carcinomas All sarcomas and carcinomas examined contained LPL activity. 7912239 Human
lpl sarcomas All sarcomas and carcinomas examined contained LPL activity. 7912239 Human
lpl human osteosarcoma Immunocytochemical studies showed that LPL was present in cultured human osteosarcoma cells and distributed throughout the cells. 7912239 Human
lpl tumor We determined the proliferating cell nuclear antigen (PCNA)-labeling index as an indicator of the proliferative activity of tumor cells and measured LPL activity in extracts of tumors in areas corresponding to those used for determining the PCNA-labeling 7912239 Human
lpl tumors We determined the proliferating cell nuclear antigen (PCNA)-labeling index as an indicator of the proliferative activity of tumor cells and measured LPL activity in extracts of tumors in areas corresponding to those used for determining the PCNA-labeling 7912239 Human
lpl tumors These findings indicate heterogeneity in the distributions of LPL activity within tumors and higher levels of LPL activity in tumors that are proliferating actively. 7912239 Human
lpl ehrlich ascites tumor Lipoprotein lipase (LPL), which is responsible for the hydrolysis of lipoprotein triacylglyceride, has been examined in Ehrlich ascites tumor cells. 7920442 Human
lpl tumor These results suggest that the stimulatory release of LPL activity by DXS is associated with the activation of TK in the tumor cells. 7920442 Human
lpl or malignancy Alterations in lipid metabolism characterized in major part by a decrease in lipoprotein lipase (LPL) activity in adipose tissue are a central feature of cachexia from chronic infection or malignancy. 7948751 Human
lpl breast tumors Significantly, a high occurrence of alterations in microsatellite polymorphisms at the ANK1, D8S135 and LPL loci of chromosome 8p (46-54%), the D2S119 locus of chromosome 2p (56%), the D10S197 locus at chromosome 10p (88%), and the nm23-H1 locus of chromo 7970728 Human
lpl cancer Leukemia inhibitory factor (LIF), a recently discovered cytokine, has been suggested to play a role in the cancer cachexia syndrome through its ability to decrease lipoprotein lipase (LPL) activity. 8013346 Human
lpl cancer These results demonstrate that the catabolic effects of LIF are weaker than those of TNF and are predominantly directed toward decreasing LPL activity, which may contribute to the hyperlipidemia associated with infection, inflammation, and cancer. 8013346 Human
lpl malignant tumors Cosmid probes for two chromosome 8p loci (LPL/8p22 and D8S7/8p23) were used in 34 specimens of malignant tumors obtained by the touch biopsy technique. 8084616 Human
lpl tumor When the deletion pattern was graded as (1) no deletion (2) partial deletion (either D8S7 or LPL deleted) and (3) both deletions, the degree of deletion was well correlated with the tumor grade (P = 0.0009) and with stage (P = 0.0072, Fisher's Exact 8084616 Human
lpl prostatic cancers Detailed mapping demonstrated variability in the size of the chromosomal region showing LOH; however, the data suggest a common 30-centimorgan region of LOH on chromosome 8p between the LPL locus and pter in colorectal and prostatic cancers. 8291601 Human
lpl hepatoma A mouse (BWTG3) and a rat (7777) hepatoma, both of which exhibit characteristics of fetal hepatocytes, were found to contain LPL mRNA, whereas the more differentiated human (Hep G2 and Hep 3B) or rat (Fa32) hepatoma cell lines did not. 8394833 Rat
lpl hepatoma Somatic cell hybrids between LPL-producing hepatoma cells and non-LPL-producing cells, such as adult rat hepatocytes or fibroblasts, exhibited extinction of LPL gene expression. 8394833 Rat
lpl leydig cell tumor Rates of lipogenesis and lipoprotein lipase (LPL) activity were measured in liver, adipose tissue, heart, and tumor at several stages during 10 days of palpable growth of a transplantable Leydig cell tumor in rats. 8446517 Rat
lpl tumor Rates of lipogenesis and lipoprotein lipase (LPL) activity were measured in liver, adipose tissue, heart, and tumor at several stages during 10 days of palpable growth of a transplantable Leydig cell tumor in rats. 8446517 Rat
lpl tumor In contrast, LPL activity in adipose tissue was depressed from the earliest stage of tumor growth, and this is likely to be a major cause of lipid depletion in cancer. 8446517 Rat
lpl cancer In contrast, LPL activity in adipose tissue was depressed from the earliest stage of tumor growth, and this is likely to be a major cause of lipid depletion in cancer. 8446517 Rat
lpl tumor There was no difference in adipose tissue LPL activity between the fed and postabsorptive states in the tumor-bearing rats, indicating that the normal response to nutrient intake was impaired. 8446517 Rat
lpl tumours From study of tumours showing break-points within 8p, a common region of deletion was established extending centromerically from LPL to the ankyrin 1 gene (ANK1) which is mapped to 8p21.1-11.2. 8479756 Human
lpl adrenocortical carcinoma Furthermore, the human adrenocortical carcinoma cell line, NCI-H295, expresses LPL mRNA and protein, which is localized to the outer cellular membrane as demonstrated by immunofluorescence confocal microscopy and can be released in the medium by heparin a 8663337 Human
lpl adrenocortical carcinoma These data indicate that LPL is expressed in human adrenal cortex and regulated in NCI-H295 adrenocortical carcinoma cells by activators of the protein kinase A and protein kinase C second messenger pathways in a manner comparable to P450scc, which cataly 8663337 Human
lpl osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lpl human osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lpl osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lpl xanthomas A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. 8725150 Human
lpl methylcholanthrene-induced sarcoma The role of insulin resistance in the tumor-induced decrease in tissue lipoprotein lipase (LPL) activity was studied in vivo and vitro in methylcholanthrene-induced sarcoma-bearing rats. 8727949 Rat
lpl tumor Intraperitoneal (i.p.) injection of 2U of regular insulin resulted in high-adipose LPL activity in control rats (CTR) of 122.0 +/- 42.4 U/mg tissue, but it had little effect on tumor-bearing rats (TBR), which showed a value of only 9.6 +/- 5.5 U/mg tissue 8727949 Rat
lpl tumor These results suggest that the decreased LPL activities seen in the tumor-bearing state may be mediated by insulin resistance. 8727949 Rat
lpl necrosis Post-heparin plasma (PHP) lipoprotein lipase (LPL) activity and serum lipoprotein concentration were examined in Japanese Black cows affected with fat necrosis. 8762610 Cow
lpl cancers On chromosome 8p, 29% of cancers had deletions at the LPL locus on 8p22 and 60% had deletions within a region flanked by the markers D8S339 and ANKI on 8p 11.1-p21.1. 8797871 Human
lpl lipomas Glycosylation of lipoprotein lipase (LPL) was studied in human subcutaneous lipomas. 8820986 Human
lpl lipomas Heparin-releasable LPL activities were higher in lipomas than those in adjacent normal adipose tissues, and showed good correlation with cellular LPL protein mass. 8820986 Human
lpl lipomas These results suggest that partially sensitive subunits constitute the major secretable form of LPL in human subcutaneous lipomas. 8820986 Human
lpl hepatoma Increase of LPL release by glucagon and adrenaline agrees with the increased LPL expression we previously found in an undifferentiated hepatoma cell line when the adenylate cyclase/protein kinase A pathway was activated. 8822270 Human
lpl tumor The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 Human
lpl lung cancer The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 Human
lpl cancer The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 Human
lpl cancer We attempted to reverse cancer cachexia by stimulating LPL activity with an antihypertriglyceridemic drug, bezafibrate. 8919277 Human
lpl tumor These results suggest that the decreased LPL activity that occurs in the tumor-bearing state can be stimulated by the antihyperlipidemic drug bezafibrate, which may modulate some of the tumor-bearing state can be stimulated by the antihyperlipidemic drug 8919277 Human
lpl cancer These results suggest that the decreased LPL activity that occurs in the tumor-bearing state can be stimulated by the antihyperlipidemic drug bezafibrate, which may modulate some of the tumor-bearing state can be stimulated by the antihyperlipidemic drug 8919277 Human
lpl tumour Both white (WAT) and brown (BAT) adipose tissue lipoprotein lipase (LPL) activities were increased at day 4 of tumour growth, changes that seem to be related with those observed in [14C]lipid accumulation; however, heart LPL activity was increased at day 8974077 Rat
lpl ascites hepatoma The inoculation of the Yoshida AH-130 ascites hepatoma to rats resulted in an important loss of adipose tissue associated with a decrease in lipoprotein lipase (LPL) activity. 9018104 Rat
lpl tumour Administration of phentolamine (an alpha-adrenergic antagonist) to tumour-bearing rats did not influence LPL activity, but it reversed the increase in plasma triglycerides associated with tumour burden. 9018104 Rat
lpl tumour Tumour burden also inflicted an important decrease in total lipoprotein lipase (LPL) activity in epididymal white adipose tissue (50%) in the wild-type mice while no changes were observed in the knockout mice. 9324050 Mouse
lpl cancer It is concluded that although TNF seems to be to some extent responsible for adipose waste, LPL changes and hyperlipaemia (via receptor I), the role of other cytokines (alone or in combination with TNF) in promoting changes in lipid metabolism during canc 9324050 Human
lpl tumor Alterations in fat metabolism have been reported to be associated with suppression of tissue lipoprotein lipase (LPL) activity in tumor-bearing animals. 9356883 Human
lpl cancer Interleukin-6 (IL- 6) has been documented to reduce tissue LPL activity and may play a role in inducing cancer cachexia. 9356883 Human
lpl gastrointestinal cancer This study was conducted to clarify the changes in LPL activity and the role of IL-6 in patients with either gastrointestinal cancer or breast cancer. 9356883 Human
lpl tumor RESULTS: LPL activity was suppressed with tumor progression in patients with either gastrointestinal cancer or breast cancer. 9356883 Human
lpl gastrointestinal cancer RESULTS: LPL activity was suppressed with tumor progression in patients with either gastrointestinal cancer or breast cancer. 9356883 Human
lpl breast cancer RESULTS: LPL activity was suppressed with tumor progression in patients with either gastrointestinal cancer or breast cancer. 9356883 Human
lpl colorectal cancer Suppression of LPL activity and the degree of weight loss were negatively correlated in patients with either gastric or colorectal cancer (r = -0.5826, p = 0.011) but not in patients with breast cancer. 9356883 Human
lpl breast cancer Suppression of LPL activity and the degree of weight loss were negatively correlated in patients with either gastric or colorectal cancer (r = -0.5826, p = 0.011) but not in patients with breast cancer. 9356883 Human
lpl tumor The decrease in LPL activity was not always reversed after resection of the tumor. 9356883 Human
lpl breast cancer CONCLUSIONS: Reduced LPL activity in patients with advanced gastrointestinal or breast cancer may reflect changes in nutritional status. 9356883 Human
lpl leydig cell tumor LPL activity of rat adipose tissue was decreased, the weight of adipose tissue was decreased, carcass weight was reduced, and food consumption was decreased after Leydig cell tumor inoculation. 9440486 Rat
lpl leydig cell tumor The present results suggest that the novel compound NO-1886 may suppress carcass weight loss in rats bearing Leydig cell tumor by suppressing the decrease in food consumption and LPL activity. 9440486 Rat
lpl tumor In this study, we examined the regulatory step of LPL in lipoprotein metabolism of Ehrlich ascites tumor and especially the enzyme-release from the tumor cells. 9464489 Human
lpl ehrlich ascites tumor In this study, we examined the regulatory step of LPL in lipoprotein metabolism of Ehrlich ascites tumor and especially the enzyme-release from the tumor cells. 9464489 Human
lpl tumor When LPL was stimulated to release from the tumor cells by the low molecular weight dextran sulfate (3.2 kDa), cyclic AMP content in the tumor cells was observed to increase rapidly in a time-dependent manner up to 30 s; its maximal effect was 1.5-fold hi 9464489 Human
lpl tumor In addition, the release of LPL activity from the tumor cells was inhibited by 2',5'-dideoxyadenosine. 9464489 Human
lpl tumor These results suggest that LPL in the tumor cells is released through a pathway involving an activation of PKA associated with the rapid increase in cyclic AMP content. 9464489 Human
lpl invasive carcinoma The highest frequency of allele losses in dysplasia (20% and 17%), and invasive carcinoma (40% and 48%) were detected in the same D8S298 and LPL-tet loci located on chromosomes 8p21 and 8p22 respectively. 9662330 Human
lpl hepatoma Human hepatocytes in primary culture and human Hep3B hepatoma cells were incubated in medium containing doubly radiolabeled HDL3 with or without LPL. 9684736 Human
lpl hepatoma Decreased lipoprotein lipase (LPL) activities in epididymal adipose tissue, cardiac muscle, and gastrocnemius as well as increased fatty acid mobilization from adipose tissue were considered to be responsible for the hepatoma-induced hypertriglyceridemia, 9778138 Rat
lpl neoplasias We used a fluorescent system to assess microsatellite changes in seven loci (D2S123, D3S643, D5S107, LPL, D17S261, TP53, and D18S34) of 73 consecutive patients with various hematological neoplasias. 9816337 Human
lpl hepatoma Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A. Recently, it was shown that lipoprotein lipase (LPL) was produced in neonatal but not in adult rat liver. 1327133 Rat
lpl hepatoma In an attempt to further define the mechanism involved in liver LPL expression, we identified a neonatal mouse hepatoma cell line, BWTG3, capable of producing LPL. 1327133 Mouse
lpl cancer Thus, IL-6 reduces adipose LPL activity and may contribute to the loss of body fat stores associated with some cases of cancer cachexia. 1638523 Mouse
lpl tumor To elucidate the mechanisms of hypertriglyceridemia observed in the tumor-bearing rat, tissue lipoprotein lipase (LPL) activity and LPL mRNA levels were examined in the fed and fasted states at different degrees of tumor burden and after tumor removal. 1988126 Human
lpl tumor LPL activity in the epididymal fat pad and cardiac muscle in the 24-h-fasted rats was significantly decreased with increasing tumor burden (r = -0.53, P less than 0.05 and r = -0.72, P less than 0.01, respectively). 1988126 Rat
lpl tumor In contrast, no change in LPL activity was detected in the fed state since food intake stimulated LPL activity to the same extent in both tumor-bearing (TBR) and control rats. 1988126 Rat
lpl tumor In contrast, there was no significant difference in LPL mRNA levels in cardiac muscle between the two groups despite significantly suppressed enzyme activity in tumor bearers. 1988126 Rat
lpl tumor This study provides evidence that hypertriglyceridemia in TBR is due in part to tumor-dependent suppression of adipose and cardiac LPL activity in the fasted state, which is stimulated by the presence of tumor. 1988126 Rat
lpl tumor Unlike cardiac LPL, the tumor-induced changes in adipose LPL activity are regulated at the mRNA level in this tumor model. 1988126 Rat
lpl monocytic leukemia The effect of dexamethasone on lipoprotein lipase (LPL) gene expression during macrophage differentiation was investigated by using the human monocytic leukemia cell line THP-1 and human monocyte-derived macrophages. 2001346 Human
lpl melanoma Conditioned medium from cultures of this melanoma cell line contains a factor(s) that inhibits the activity of lipoprotein lipase (LPL) in fully differentiated 3T3-L1 adipocytes. 2016276 Human
lpl colon adenocarcinoma The effect of weight loss during cancer cachexia on the plasma levels of free fatty acids (FFA) and triglycerides, and on the tissue levels of lipoprotein lipase (LPL), has been studied in mice bearing an experimental colon adenocarcinoma (MAC16). 2025878 Mouse
lpl cancer The effect of weight loss during cancer cachexia on the plasma levels of free fatty acids (FFA) and triglycerides, and on the tissue levels of lipoprotein lipase (LPL), has been studied in mice bearing an experimental colon adenocarcinoma (MAC16). 2025878 Mouse
lpl tumor In particular, the presence of the tumor seems to profoundly affect triglyceride (TG) utilization by interfering with lipoprotein lipase (LPL) activity. 2134527 Human
lipoprotein lipase mesothelioma Human chylomicrons, obtained from chylous pleural fluid of a patient with mesothelioma, were incubated with bovine milk lipoprotein lipase. 2553422 Human
lipoprotein lipase tumour 8. In contrast with the gradual development of mammary-gland lipogenic enzyme activities, lipoprotein lipase activity was high in the gland by 2 days post partum; starvation or tumour burden decreased the activity. 2590173 Rat
lipoprotein lipase melanoma Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia. 2730639 Human
lipoprotein lipase cancer Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia. 2730639 Human
lipoprotein lipase monocytic leukemia Lipoprotein lipase (LPL) mRNA levels are under the control of signals that activate phospholipase C, resulting in activation of protein kinase C (PKC) and mobilization of intracellular Ca2+ in the human monocytic leukemia cell line THP-1. 2765502 Human
lipoprotein lipase cancer [Blood lipase activity in cancer patients] Blood plasma lipoprotein lipase level was measured in lung and stomach cancer patients before surgery and during postoperative period. 2773395 Human
lipoprotein lipase tumor The hTNF-synthetic peptides and hTNF fragments were tested in hTNF receptor binding assays and in two biologic assays: cytolysis of tumor cells and suppression of lipoprotein lipase in adipocytes. 2827156 Human
lipoprotein lipase tumor The regulation of secretion of lipoprotein lipase (LPL) was studied in in vitro-derived mouse bone marrow macrophages (BMM), peritoneal exudate and resident macrophages and in the macrophage-like tumor cell line J774.1. 2917136 Mouse
lipoprotein lipase cancers Hepatic triglyceride lipase and lipoprotein lipase activities in post-heparin plasma of patients with various cancers. 2987072 Human
lipoprotein lipase cancers The total post-heparin lipolytic activity (PHLA) and hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) activities in post-heparin plasma of patients with various cancers were measured. 2987072 Human
lipoprotein lipase endometrial cancer The effect of high dose medroxyprogesterone acetate (MPA) on serum lipids, on adipose tissue lipoprotein lipase (LPL) and serum lecithin cholesterol acyltransferase activities were studied in 15 postmenopausal patients with endometrial cancer. 3155702 Human
lipoprotein lipase tumor This suggests that the activity of lipoprotein lipase in mammary tissue is not sensitive to the tumor as it appears to be in adipose tissue of non-lactating rats. 3250234 Rat
lipoprotein lipase craniopharyngioma Elevated adipose tissue lipoprotein lipase activity in craniopharyngioma patients. 3285130 Human
lipoprotein lipase craniopharyngioma The activity of lipoprotein lipase (LPL) was measured in adipose tissue (AT-LPL) and postheparin plasma (PH-LPL) of 13 obese patients (aged 11 to 31 years) who had surgery for craniopharyngioma 1 to 13 years earlier. 3285130 Human
lipoprotein lipase tumour 5. In lactating animals, tumour burden had little effect on the accompanying hyperphagia or on pup weight gain; tissue lipogenesis was unaffected, as was tissue [14C]lipid accumulation, plasma [triacylglycerol] and white-adipose-tissue and mammary-gland l 3421910 Rat
lipoprotein lipase tumour 6. On removal (24 h) of the litter, the presence of the tumour resulted in decreased rates of lipogenesis in the carcass, liver and white and brown adipose tissue, decreased [14C]lipid accumulation in white adipose tissue, but increased accumulation in pl 3421910 Rat
lipoprotein lipase myeloma The spleen was removed from the animal having the highest titer of inhibitory antibodies to lipoprotein lipase and the cells were fused mouse myeloma cells. 3756191 Human
lipoprotein lipase cancer Total lipoprotein lipase activity was decreased by 35.4% (P less than 0.001) in the cancer group. 3781475 Human
lipoprotein lipase monocytic leukemia Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. 3855620 Human
lipoprotein lipase pancreatic carcinomas [Elective induction in mice of solid and ascitic carcinoma of the exocrine pancreas by the repeated doses of antibodies against a lipoprotein lipase fraction] Small doses, repeated for months of anti-esterase-lipoprotein antibodies, from several antisera 403027 Mouse
lipoprotein lipase myeloma Three monoclonal antibodies to avian lipoprotein lipase have been isolated by fusing spleen cells from immunized BALB/c mice with myeloma P3X-63 Ag 8. 4041471 Human
lipoprotein lipase hyperplasia The induction of a hypothyroid state resulted in thyroid hyperplasia, with decreased thyroid iodine content, altered serum thyroid relating hormone levels (increased TSH and decreased T3 and T4), elevated serum total cholesterol and reduced serum triacylg 4078646 Rat
lipoprotein lipase sarcoma 180 Lipoprotein lipase-like activity in the liver of mice with Sarcoma 180. 6376672 Mouse
lipoprotein lipase tumor Sequential changes in the activities of lipoprotein lipase and lipogenic enzymes during tumor growth in rats. 6386147 Rat
lipoprotein lipase xanthomas A literature review of 23 reported cases indicates that xanthomas and hepatosplenomegaly are less common in C-II anapolipoproteinemia than in lipoprotein lipase deficiency, the other major etiologic cause of genetic chylomicronemia. 6475985 Human
lipoprotein lipase lipoma In 13 men the lipoprotein lipase activity of lipoma was markedly higher compared with the adjacent normal adipose tissue (40.4 +/- 15.5 versus 14.0 +/- 11.7 nmoles/gm/minute at 37 degrees C, p = 0.001) or to control adipose tissue (9.6 +/- 7.2 nmoles of f 6482388 Human
lipoprotein lipase lipoma It is likely that the high lipoprotein lipase activity of lipoma contributes to the growth of the tumor. 6482388 Human
lipoprotein lipase tumor It is likely that the high lipoprotein lipase activity of lipoma contributes to the growth of the tumor. 6482388 Human
lipoprotein lipase tumor Changes in lipoprotein lipase activity (LPLA) in tumor cells and tissues in mice bearing Ehrlich ascites tumor. 6525466 Mouse
lipoprotein lipase ehrlich ascites tumor Changes in lipoprotein lipase activity (LPLA) in tumor cells and tissues in mice bearing Ehrlich ascites tumor. 6525466 Mouse
lipoprotein lipase ehrlich ascites tumor Lipid content and lipoprotein lipase activity (LPLA) of serum and various tissues of mice bearing Ehrlich ascites tumor have been studied. 6525466 Human
lipoprotein lipase tumor Lipoprotein lipase had already started to decline on day 2 following tumor transplantation. 6712971 Mouse
lipoprotein lipase multiple symmetric lipomatosis Metabolic abnormalities in multiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissue with hyperalphalipoproteinemia. 6875381 Human
lipoprotein lipase multiple symmetric lipomatosis (msl) Lipoprotein lipase activity in lipomatous tissue, post-heparin lipoprotein lipase activity in plasma, and the composition and concentration of serum lipoproteins were studied in 15 patients with Multiple Symmetric Lipomatosis (MSL). 6875381 Human
lipoprotein lipase tumor Changes in the activities of lipoprotein lipase and the lipogenic enzymes in tumor-bearing rats. 6984480 Rat
lipoprotein lipase tumor The effects of tumor growth on lipid metabolism were investigated by evaluating serum lipids, lipoprotein lipase activity (LPLA), the lipogenic enzymes, urinary catecholamines along with serum insulin and glucagon levels. 6984480 Rat
lipoprotein lipase prolactinoma Oral glucose tolerance tests (OGTT) were performed and postheparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities were determined in twelve patients before and after transsphenoidal removal of the prolactinoma. 7047001 Human
lipoprotein lipase tumor Modified lipoprotein lipase activities, rates of lipogenesis, and lipolysis as factors leading to lipid depletion in C57BL mice bearing the preputial gland tumor, ESR-586. 7248977 Mouse
lipoprotein lipase tumor The first change, before the tumor reached 2 g, was a decline in the activity of adipose tissue lipoprotein lipase to levels normally found in starved animals. 7248977 Mouse
lipoprotein lipase large tumors This was accompanied by a slight increase in lipoprotein lipase activity in heart and appearance of substantial activity in large tumors. 7248977 Mouse
lipoprotein lipase cancer Tumor cell products with activity to inhibit lipoprotein lipase (LPL) were shown to play an important role in the development of the cancer cachexia syndrome. 7622421 Human
lipoprotein lipase tumors Loss of one allele is identified in 14 of 23 (61%) tumors at D8S163, in 15 of 32 (47%) tumors at lipoprotein lipase, and in 20 of 29 (69%) tumors at MSR, all on 8p22. 7689419 Human
lipoprotein lipase tumor Effect of intralipid infusion on serum high- and low-density lipoprotein cholesterol, lecithin:cholesterol acyltransferase, and lipoprotein lipase in tumor-bearing rats. 7698286 Rat
lipoprotein lipase fibrosarcoma We compared the effects of 0.45% normal saline (NS), 5% Intralipid (IL), and 16.7% glucose (Glu) infusions on total serum triglycerides and cholesterol, serum high-(HDL-c) and low-density lipoprotein cholesterol (LDL-c), and activity of serum lecithin:cho 7698286 Human
lipoprotein lipase prostatic carcinomas Polymorphic alleles at loci such as LPL (lipoprotein lipase) and MSR (macrophage scavenger receptor) in chromosome band 8p22 are frequently lost during the genesis of several types of human cancer, including colorectal, non-small cell lung, hepatocellular 7698754 Human
lipoprotein lipase cancer Polymorphic alleles at loci such as LPL (lipoprotein lipase) and MSR (macrophage scavenger receptor) in chromosome band 8p22 are frequently lost during the genesis of several types of human cancer, including colorectal, non-small cell lung, hepatocellular 7698754 Human
lipoprotein lipase carcinomas Existence of lipoprotein lipase in human sarcomas and carcinomas. 7912239 Human
lipoprotein lipase sarcomas Existence of lipoprotein lipase in human sarcomas and carcinomas. 7912239 Human
lipoprotein lipase ehrlich ascites tumor Stimulatory release of lipoprotein lipase activity with activation of protein tyrosine kinase produced by low molecular weight dextran sulfate in Ehrlich ascites tumor cells. 7920442 Human
lipoprotein lipase ehrlich ascites tumor Lipoprotein lipase (LPL), which is responsible for the hydrolysis of lipoprotein triacylglyceride, has been examined in Ehrlich ascites tumor cells. 7920442 Human
lipoprotein lipase or malignancy Alterations in lipid metabolism characterized in major part by a decrease in lipoprotein lipase (LPL) activity in adipose tissue are a central feature of cachexia from chronic infection or malignancy. 7948751 Human
lipoprotein lipase yoshida ascites hepatoma 1. Rats bearing the Yoshida ascites hepatoma AH-130 showed an important decrease in white adipose tissue lipoprotein lipase activity as compared with non-tumour bearing rats. 7955912 Rat
lipoprotein lipase tumour 1. Rats bearing the Yoshida ascites hepatoma AH-130 showed an important decrease in white adipose tissue lipoprotein lipase activity as compared with non-tumour bearing rats. 7955912 Rat
lipoprotein lipase tumour Anti-tumour necrosis factor-alpha treatment resulted in a significant increase in lipoprotein lipase activity in white adipose tissue in animals bearing a tumour growing exponentially (day 4 after inoculation) as compared with the animals receiving a non- 7955912 Rat
lipoprotein lipase tumour In addition, animals bearing an stationary tumour (day 7 after inoculation) and submitted to anti-tumour necrosis factor-alpha treatment had a higher adipose tissue lipoprotein lipase activity as compared with the IgG- or the non-treated groups. 7955912 Rat
lipoprotein lipase cancer Leukemia inhibitory factor (LIF), a recently discovered cytokine, has been suggested to play a role in the cancer cachexia syndrome through its ability to decrease lipoprotein lipase (LPL) activity. 8013346 Human
lipoprotein lipase carcinoma Reduction of synthetic rate of lipoprotein lipase in adipose tissues of patients with carcinoma. 8110506 Human
lipoprotein lipase tumor The tissue lipoprotein lipase activities in the epididymal fat pads of the tumor bearers were significantly decreased compared with the controls (P < 0.01). 8369614 Human
lipoprotein lipase cancer The total lipoprotein lipase enzymic activity and the relative levels of the mRNAs for lipoprotein lipase and for fatty acid synthase were not significantly different between cancer patients and control patients. 8422428 Human
lipoprotein lipase leydig cell tumor Rates of lipogenesis and lipoprotein lipase (LPL) activity were measured in liver, adipose tissue, heart, and tumor at several stages during 10 days of palpable growth of a transplantable Leydig cell tumor in rats. 8446517 Human
lipoprotein lipase human hepatoma Inhibition of lipoprotein lipase induced cholesterol ester accumulation in human hepatoma HepG2 cells. 8645351 Human
lipoprotein lipase osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lipoprotein lipase osteosarcoma The effect of recombinant human tumour necrosis factor-alpha (TNF-alpha) on synthesis, activity and secretion of lipoprotein lipase (LPL) was examined using a human osteosarcoma cell line, osteosarcoma Takase (OST). 8670156 Human
lipoprotein lipase xanthomas A woman with primary lipoprotein lipase (LPL) deficiency developed marked hypertriglyceridemia, pancreatitis, eruptive xanthomas, and unusual palmar xanthomas during pregnancy. 8725150 Human
lipoprotein lipase tumor Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats. 8727949 Rat
lipoprotein lipase methylcholanthrene-induced sarcoma The role of insulin resistance in the tumor-induced decrease in tissue lipoprotein lipase (LPL) activity was studied in vivo and vitro in methylcholanthrene-induced sarcoma-bearing rats. 8727949 Rat
lipoprotein lipase tumours These results indicate that HCO-60 emulsions, compared with conventional LEC emulsions, are more stable to lipoprotein lipase and show low uptakes by RES organs, long circulations in the plasma, and high distributions in tumours. 8743404 Rat
lipoprotein lipase lipomas Glycosylation of lipoprotein lipase in human subcutaneous lipomas. 8820986 Human
lipoprotein lipase lipomas Glycosylation of lipoprotein lipase (LPL) was studied in human subcutaneous lipomas. 8820986 Human
lipoprotein lipase hepatoma Changes in serum lipid levels and adipose tissue lipase (lipoprotein lipase and hormone-sensitive lipase) activities following injection of lipopolysaccharide into normal rats resembled those in hepatoma-bearing rats. 8901118 Rat
lipoprotein lipase tumor Stimulation of decreased lipoprotein lipase activity in the tumor-bearing state by the antihyperlipidemic drug bezafibrate. 8919277 Human
lipoprotein lipase tumor The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 others
lipoprotein lipase lung cancer The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 Human
lipoprotein lipase cancer The activity of lipoprotein lipase (LPL), a key regulatory enzyme for triglyceride (TG) clearance from plasma, is reported to decrease as the tumor burden increases in tumor-bearing animals and patients with lung cancer; therefore, it is believed to play 8919277 Human
lipoprotein lipase tumour Both white (WAT) and brown (BAT) adipose tissue lipoprotein lipase (LPL) activities were increased at day 4 of tumour growth, changes that seem to be related with those observed in [14C]lipid accumulation; however, heart LPL activity was increased at day 8974077 Rat
lipoprotein lipase ascites hepatoma The inoculation of the Yoshida AH-130 ascites hepatoma to rats resulted in an important loss of adipose tissue associated with a decrease in lipoprotein lipase (LPL) activity. 9018104 Rat
lipoprotein lipase ascites hepatoma Sequential changes in lipoprotein lipase activity and lipaemia induced by the Yoshida AH-130 ascites hepatoma in rats. 9215859 Rat
lipoprotein lipase all Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity. 9264396 Human
lipoprotein lipase tumour Tumour burden also inflicted an important decrease in total lipoprotein lipase (LPL) activity in epididymal white adipose tissue (50%) in the wild-type mice while no changes were observed in the knockout mice. 9324050 Mouse
lipoprotein lipase cancer Plasma interleukin-6 is not a mediator of changes in lipoprotein lipase activity in cancer patients. 9356883 Human
lipoprotein lipase tumor Alterations in fat metabolism have been reported to be associated with suppression of tissue lipoprotein lipase (LPL) activity in tumor-bearing animals. 9356883 others
lipoprotein lipase leydig cell tumor Suppression of carcass weight loss in cachexia in rats bearing Leydig cell tumor by the novel compound NO-1886, a lipoprotein lipase activator. 9440486 Rat
lipoprotein lipase leydig cell tumor We administered NO-1886, a lipoprotein lipase activator, to rats bearing Leydig cell tumor and observed its effect on improving the cachexia induced by the tumor. 9440486 Rat
lipoprotein lipase tumor We administered NO-1886, a lipoprotein lipase activator, to rats bearing Leydig cell tumor and observed its effect on improving the cachexia induced by the tumor. 9440486 Rat
lipoprotein lipase ehrlich ascites tumor Release of lipoprotein lipase from Ehrlich ascites tumor produced by an association with a rapid increase in cyclic AMP content. 9464489 Human
lipoprotein lipase hepatoma Decreased lipoprotein lipase (LPL) activities in epididymal adipose tissue, cardiac muscle, and gastrocnemius as well as increased fatty acid mobilization from adipose tissue were considered to be responsible for the hepatoma-induced hypertriglyceridemia, 9778138 Rat
lipoprotein lipase lipomas Lipoprotein lipase and hormone-sensitive lipase activities in human subcutaneous lipomas: comparison with normal subcutaneous adipose tissue. 1261213 Human
lipoprotein lipase lipomas 2. Confirmation was obtained of the presence of lipoprotein lipase activity in lipomas with an activity fifteen to forty-five times that in the two control samples. 1261213 Human
lipoprotein lipase plasmacytoma It has been shown that IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, enhances antigen-specific antibody responses, synergizes with IL-3 in supporting megakaryocyte colony formation, acts synergistically with IL-3 in short 1292471 Human
lipoprotein lipase hepatoma Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A. Recently, it was shown that lipoprotein lipase (LPL) was produced in neonatal but not in adult rat liver. 1327133 Rat
lipoprotein lipase tumour Before removal of the tumour, the use of beta blockers alone led to marked deterioration of the hyperlipidaemic state, and combined alpha and beta blockade additionally led to a marked reduction in fat oxidation and lipoprotein lipase activity. 1630985 Human
lipoprotein lipase cancer Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. 1638523 Mouse
lipoprotein lipase tumour The increased lipid accumulation in the heart, but not the tumour correlated with an increased tissue lipoprotein lipase level. 1764364 others
lipoprotein lipase neoplasm Lipid metabolism is also affected by the neoplasm: soluble factors such as "lipid-mobilizing factor" lead to increased fat mobilization from adipose tissue; plasma elimination of exogenous triglycerides has also been found to be reduced probably 1766060 Human
lipoprotein lipase tumor To elucidate the mechanisms of hypertriglyceridemia observed in the tumor-bearing rat, tissue lipoprotein lipase (LPL) activity and LPL mRNA levels were examined in the fed and fasted states at different degrees of tumor burden and after tumor removal. 1988126 Human
lipoprotein lipase monocytic leukemia The effect of dexamethasone on lipoprotein lipase (LPL) gene expression during macrophage differentiation was investigated by using the human monocytic leukemia cell line THP-1 and human monocyte-derived macrophages. 2001346 Human
lipoprotein lipase melanoma Suppression of lipoprotein lipase in 3T3-L1 cells by a mediator produced by SEKI melanoma, a cachexia-inducing human melanoma cell line. 2016276 Human
lipoprotein lipase melanoma Conditioned medium from cultures of this melanoma cell line contains a factor(s) that inhibits the activity of lipoprotein lipase (LPL) in fully differentiated 3T3-L1 adipocytes. 2016276 Human
lipoprotein lipase colon adenocarcinoma The effect of weight loss during cancer cachexia on the plasma levels of free fatty acids (FFA) and triglycerides, and on the tissue levels of lipoprotein lipase (LPL), has been studied in mice bearing an experimental colon adenocarcinoma (MAC16). 2025878 Mouse
lipoprotein lipase cancer The effect of weight loss during cancer cachexia on the plasma levels of free fatty acids (FFA) and triglycerides, and on the tissue levels of lipoprotein lipase (LPL), has been studied in mice bearing an experimental colon adenocarcinoma (MAC16). 2025878 Mouse
lipoprotein lipase tumor In particular, the presence of the tumor seems to profoundly affect triglyceride (TG) utilization by interfering with lipoprotein lipase (LPL) activity. 2134527 Human
lipoprotein lipase monocytic leukemia DNA sequence of lipoprotein lipase cDNA cloned from human monocytic leukemia THP-1 cells. 2243796 Human
lpl b16 melanoma Our recent study has demonstrated that B16 melanoma-induced cachexia in mice is inhibited by ponalrestat, an aldose reductase inhibitor, which has the ability to activate lipoprotein lipase (LPL) activity both in vitro and in vivo. 10628360 Mouse
lpl b16 melanoma In this study, the effect of bezafibrate and NO-1886, LPL activators, on B16 melanoma-induced cachectic symptoms was investigated in mice. 10628360 Human
lpl lymphoma Overall, this study indicated that EL-4 lymphoma in mice results in a severe cachexia which is possibly related to impaired LPL activity and also provided a useful cachexia model for understanding the role of LPL in the development of cancer cachexia. 11062730 Mouse
lpl neuroblastoma Using a neuroblastoma cell line transfected with a NEO- or a LPL-expression vector, we have developed a model to study the function of LPL in neurons exposed to native or copper-oxidized lipoproteins. 12501246 Human
lpl neuroblastoma In summary, these data show that the availability of fatty acids, resulting from the catabolism of VLDL by LPL, is required to promote the phenotypical differentiation of neuroblastoma cells. 15013626 Human
lipoprotein lipase b16 melanoma Activation of lipoprotein lipase and inhibition of B16 melanoma-induced cachexia in mice by ponalrestat, an aldose reductase inhibitor. 10226565 Mouse
lipoprotein lipase b16 melanoma Effect of lipoprotein lipase activators bezafibrate and NO-1886, on B16 melanoma-induced cachexia in mice. 10628360 Human
lipoprotein lipase b16 melanoma Our recent study has demonstrated that B16 melanoma-induced cachexia in mice is inhibited by ponalrestat, an aldose reductase inhibitor, which has the ability to activate lipoprotein lipase (LPL) activity both in vitro and in vivo. 10628360 Mouse
lipoprotein lipase b16 melanoma Our recent study has demonstrated that ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase activity and alleviates B16 melanoma-induced cachexia in mice. 10628361 Mouse
lipoprotein lipase lymphoma Cachexia induction by EL-4 lymphoma in mice and possible involvement of impaired lipoprotein lipase activity. 11062730 Mouse
lipoprotein lipase prostatic adenocarcinoma [Relationship between chromosome 8 alterations and Gleason score in prostatic adenocarcinoma] OBJECTIVE: To study the gain of chromosome 8 and c-myc gene and lipoprotein lipase gene status in prostatic adenocarcinoma of Chinese patients, and to analyze th 17134545 Human
lipoprotein lipase prostatic cancer C-myc gene amplification accompanied by lipoprotein lipase gene deletion is also a common occurrence in prostatic cancer. 17134545 Human

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