IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MCM3 Ensembl ENSG00000112118 Chromosome 6 Start 52236771 End 52257541
Description DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1)(RLF subunit beta)(P102 protein)(P1-MCM3) [Source:UniProtKB/Swiss-Prot;Acc:P25205]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6945
     Entrez Gene : 4172
     UCSC : uc003pan.1
     GeneCards : 6945
     RefSeq : NM_002388
     CCDS : CCDS4940.1
     Uniprot : P25205
     Interpro : P25205
     OMIM : 602693
     GeneTests : MCM3
     CGAP : MCM3
     PMID : 1549468

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up - IHC- 15623617 Clin Cancer Res. 2004 Dec 15;10(24):8386-95.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33252_at  0.22  7.54e-2  1.30e-1  0.88  1.73e-6  1.03e-5
 HG_U133A  201555_at  0.56  1.15e-17  7.62e-17  0.71  9.62e-16  1.31e-15
 HG_U133_Plus2  201555_at  0.66  6.06e-12  5.62e-11  1.42  1.72e-30  8.50e-29
 Stanford  3790  1.08  9.65e-4  1.43e-2  1.38  1.17e-3  1.57e-2
 Agilent_HS_21.6K  15012  0.25  2.69e-2  9.39e-2  0.36  5.98e-5  5.16e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201555_at  -0.25  2.03e-1  8.31e-1  0.15  3.12e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33252_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201555_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201555_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3790    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15012    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mcm3 endometrial carcinomas The authors investigated the immunohistochemical expression of MCM2 and MCM3, Ki-67, estrogen receptor, and progesterone receptor in 23 normal endometria, 9 endometrial hyperplasias, and 60 endometrial carcinomas. 14501812 Human
mcm3 endometrial hyperplasias The authors investigated the immunohistochemical expression of MCM2 and MCM3, Ki-67, estrogen receptor, and progesterone receptor in 23 normal endometria, 9 endometrial hyperplasias, and 60 endometrial carcinomas. 14501812 Human
mcm3 endometrial carcinomas In endometrial carcinomas, however, the expression of MCM2 and MCM3 was significantly lower than that in the normal proliferative endometrium. 14501812 Human
mcm3 cancer The expression of p27 and MCM3 was compared with the expression of the Ki-67 protein, an approved marker for proliferating cells, extensively used in histopathology and cancer research. 11745678 Human
mcm3 tumour In conclusion, a combined analysis of Ki-67, MCM3, and p27 protein expression may provide a more detailed insight into the cell proliferation and differentiation processes that determine individual tumour growth. 11745678 Human
mcm3 head and neck carcinoma Involvement of cyclin D1-cdk5 overexpression and MCM3 cleavage in bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model. 10495426 Human
mcm3 cancer Immunohistochemical studies of surgical materials from human uterine cervix showed that Mcm3 and 4 are ubiquitously expressed in cancer cells. 12631269 Human
mcm3 cancer Further, the positive rate and level of Mcm3 and 4 expression appeared to be higher in cancer cells than in normal proliferating cells of the uterine cervix and dysplastic cells, suggesting that they can be useful markers to distinguish these cells. 12631269 Human
mcm3 necrosis Cleavage of MCM3 can be prevented by caspase inhibitors, and it does not occur when cells are forced to undergo necrosis by energy deprivation. 9473350 Human
mcm3 individual tumour In conclusion, a combined analysis of Ki-67, MCM3, and p27 protein expression may provide a more detailed insight into the cell proliferation and differentiation processes that determine individual tumour growth. 11745678 Human
mcm3 hyperplastic Expression of replication-licensing factors MCM2 and MCM3 in normal, hyperplastic, and carcinomatous endometrium: correlation with expression of Ki-67 and estrogen and progesterone receptors. 14501812 Human
mcm3 hyperplastic These findings suggest that the expression of MCM2 and MCM3 directly reflects cell proliferation in normal and hyperplastic endometria. 14501812 Human
mcm3 cancers RESULTS: We identified a minichromosome maintenance 3 (MCM3) gene that was overexpressed in various human cancers, including leukemia, lymphoma, and carcinomas of the uterine cervix, colon, lung, stomach, kidney and breast, and malignant melanoma. 15623617 Human
mcm3 carcinomas of the uterine cervix RESULTS: We identified a minichromosome maintenance 3 (MCM3) gene that was overexpressed in various human cancers, including leukemia, lymphoma, and carcinomas of the uterine cervix, colon, lung, stomach, kidney and breast, and malignant melanoma. 15623617 Human
mcm3 leukemia RESULTS: We identified a minichromosome maintenance 3 (MCM3) gene that was overexpressed in various human cancers, including leukemia, lymphoma, and carcinomas of the uterine cervix, colon, lung, stomach, kidney and breast, and malignant melanoma. 15623617 Human
mcm3 lymphoma RESULTS: We identified a minichromosome maintenance 3 (MCM3) gene that was overexpressed in various human cancers, including leukemia, lymphoma, and carcinomas of the uterine cervix, colon, lung, stomach, kidney and breast, and malignant melanoma. 15623617 Human
mcm3 cancer Western blot and immunohistochemical analyses also revealed that MCM3 protein was elevated in most of human cancer tissues tested. 15623617 Human
mcm3 cancers We compared the MCM3 protein expression levels in human cancers with conventional proliferation markers, Ki-67 and proliferating cell nuclear antigen. 15623617 Human
mcm3 cancer The down-regulation of MCM3 protein level was examined under serum starvation in both normal and cancer cells. 15623617 Human
mcm3 breast cancer Interestingly, MCM3 protein was stable in MCF-7 breast cancer cells even up to 96 hours after serum starvation, whereas it was gradually degraded in normal BJ fibroblast cells. 15623617 Human
mcm3 tumors Nude mice who received injections of HEK 293 cells stably transfected with MCM3 formed tumors in 6 weeks. 15623617 Mouse
mcm3 tumor CONCLUSIONS: Our study indicates that determination of MCM3 expression level will facilitate the assessment of many different human malignancies in tumor diagnosis, and MCM3 is involved in multiple types of human carcino-genesis. 15623617 Human
mcm3 astrocytic tumors RESULTS: MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in 9.3% (9 of 97) of patients with brain tumors (n = 95) and brain metastases (n = 2) but not in healthy controls. 15671553 Human
mcm3 brain metastases RESULTS: MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in 9.3% (9 of 97) of patients with brain tumors (n = 95) and brain metastases (n = 2) but not in healthy controls. 15671553 Human
mcm3 brain tumors RESULTS: MCM3 is overexpressed in human astrocytic tumors and elicits a cancer-restricted humoral immune response in 9.3% (9 of 97) of patients with brain tumors (n = 95) and brain metastases (n = 2) but not in healthy controls. 15671553 Human
mcm3 diffuse astrocytoma Expression of MCM3 in diffuse astrocytoma is significantly associated with age (P < 0.001), histologic grade (P < 0.001), time to recurrence (P = 0.01), and expression of the proliferation marker Ki-67 (P < 0.001) but not with sex (P = 0.800). 15671553 Human
mcm3 astrocytoma Univariate and multivariate Cox regression analysis confirmed MCM3 expression as an independent predictor of poor outcome in astrocytoma patients (P < 0.001 for both). 15671553 Human
mcm3 diffuse astrocytoma The expression of one of the identified antigens, the replication licensing factor minichromosome maintenance protein 3 (MCM3), was analyzed by immunohistochemistry in 142 primary and 27 recurrent astrocytomas (WHO grades 2-4). 15671553 Human
mcm3 glioma The expression of one of the identified antigens, the replication licensing factor minichromosome maintenance protein 3 (MCM3), was analyzed by immunohistochemistry in 142 primary and 27 recurrent astrocytomas (WHO grades 2-4). 15671553 Human
minichromosome maintenance protein 3 anaplastic astrocytoma Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. 15671553 Human
minichromosome maintenance protein 3 astrocytic tumors In addition, 98 serum specimens from patients with primary and secondary brain malignancies and 30 serum specimens from healthy controls were examined by serologic immunoscreening for immunoreactivity with MCM3.RESULTS: MCM3 is overexpressed in human astr 15671553 Human
minichromosome maintenance protein 3 brain metastases In addition, 98 serum specimens from patients with primary and secondary brain malignancies and 30 serum specimens from healthy controls were examined by serologic immunoscreening for immunoreactivity with MCM3.RESULTS: MCM3 is overexpressed in human astr 15671553 Human
minichromosome maintenance protein 3 brain tumors In addition, 98 serum specimens from patients with primary and secondary brain malignancies and 30 serum specimens from healthy controls were examined by serologic immunoscreening for immunoreactivity with MCM3.RESULTS: MCM3 is overexpressed in human astr 15671553 Human
minichromosome maintenance protein 3 diffuse astrocytoma The expression of one of the identified antigens, the replication licensing factor minichromosome maintenance protein 3 (MCM3), was analyzed by immunohistochemistry in 142 primary and 27 recurrent astrocytomas (WHO grades 2-4). 15671553 Human
minichromosome maintenance protein 3 glioma The expression of one of the identified antigens, the replication licensing factor minichromosome maintenance protein 3 (MCM3), was analyzed by immunohistochemistry in 142 primary and 27 recurrent astrocytomas (WHO grades 2-4). 15671553 Human
minichromosome maintenance protein 3 astrocytomas In addition, 98 serum specimens from patients with primary and secondary brain malignancies and 30 serum specimens from healthy controls were examined by serologic immunoscreening for immunoreactivity with MCM3.RESULTS: MCM3 is overexpressed in human astr 15671553 Human

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