IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MELK Ensembl ENSG00000165304 Chromosome 9 Start 36562873 End 36667678
Description Maternal embryonic leucine zipper kinase (hMELK)(EC 2.7.11.1)(Protein kinase PK38)(hPK38) [Source:UniProtKB/Swiss-Prot;Acc:Q14680]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 16870
     Entrez Gene : 9833
     UCSC : uc003zzn.2
     GeneCards : 16870
     RefSeq : NM_014791
     CCDS : CCDS6606.1
     Uniprot : Q14680
     Interpro : Q14680
     OMIM : 607025
     GeneTests : MELK
     CGAP : MELK
     PMID : 8724849

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 2.70 37 0 0.00 7 1 14.29 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
PD1379a SCC c.1176+5G>A p.? Unknown Unknown 9:36647365-3664736516140923

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38847_at  1.03  8.33e-8  6.97e-7  1.60  1.81e-7  1.31e-6
 HG_U133A  204825_at  2.40  4.47e-52  2.44e-50  4.06  6.25e-68  1.95e-67
 HG_U133_Plus2  204825_at  2.30  1.52e-28  8.87e-27  3.19  2.13e-42  6.55e-40
 Agilent_HS_21.6K  12059  0.56  1.91e-6  4.28e-5  0.74  4.51e-10  2.12e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204825_at  0.27  5.09e-1  9.31e-1  -0.08  6.74e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38847_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204825_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204825_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12059    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
melk breast cancer METHODS: Using accurate genome-wide expression profiles of breast cancers, we found maternal embryonic leucine-zipper kinase (MELK) to be significantly overexpressed in the great majority of breast cancer cells. 17280616 Human
melk breast cancers METHODS: Using accurate genome-wide expression profiles of breast cancers, we found maternal embryonic leucine-zipper kinase (MELK) to be significantly overexpressed in the great majority of breast cancer cells. 17280616 Human
melk carcinogenesis To assess whether MELK has a role in mammary carcinogenesis, we knocked down the expression of endogenous MELK in breast cancer cell lines using mammalian vector-based RNA interference. 17280616 Human
melk breast cancer To assess whether MELK has a role in mammary carcinogenesis, we knocked down the expression of endogenous MELK in breast cancer cell lines using mammalian vector-based RNA interference. 17280616 Human
melk breast cancers RESULTS: Northern blot analyses on multiple human tissues and cancer cell lines demonstrated that MELK was overexpressed at a significantly high level in a great majority of breast cancers and cell lines, but was not expressed in normal vital organs (hear 17280616 Human
melk cancer RESULTS: Northern blot analyses on multiple human tissues and cancer cell lines demonstrated that MELK was overexpressed at a significantly high level in a great majority of breast cancers and cell lines, but was not expressed in normal vital organs (hear 17280616 Human
melk human breast cancer Suppression of MELK expression by small interfering RNA significantly inhibited growth of human breast cancer cells. 17280616 Human
melk carcinogenesis CONCLUSION: Our findings suggest that the kinase activity of MELK is likely to affect mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL. 17280616 Human
melk breast cancers The kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers. 17280616 Human
maternal embryonic leucine zipper kinase carcinogenesis Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. 17280616 Human
melk tumor MELK is a cell cycle-regulated protein kinase involved in cell cycle progression, proliferation, tumor growth and mRNA splicing. 17129738 Human
melk carcinogenesis Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. 17280616 Human
maternal embryonic leucine zipper kinase tumors Gene expression analysis reveals that both whole tumors and tumor-derived neurospheres express many genes characteristic of neural and other stem cells, including CD133, Sox2, musashi-1, bmi-1, maternal embryonic leucine zipper kinase, and phosphoserine p 14645703 Human
maternal embryonic leucine zipper kinase tumor Gene expression analysis reveals that both whole tumors and tumor-derived neurospheres express many genes characteristic of neural and other stem cells, including CD133, Sox2, musashi-1, bmi-1, maternal embryonic leucine zipper kinase, and phosphoserine p 14645703 Human
melk human colorectal carcinoma The mRNA expression of other AMPK family members and ARK5 was measured using RT-PCR in human colorectal carcinoma cell lines DLD-1, WiDr, HCT-15, SW620, LoVo, SW480, and mRNA expression of AMPK-alpha1, SNARK, MELK and ARK5, but not AMPK-alpha2, was detect 15354411 Human
maternal embryonic leucine zipper kinase cancers Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers. 16266996 Human
melk cancer An oligonucleotide microarray analysis of multiple human tumor samples and cell lines suggests that Melk expression is frequently elevated in cancer relative to normal tissues, a pattern confirmed by quantitative reverse transcription-PCR and Western blot 16266996 Human
melk human tumor An oligonucleotide microarray analysis of multiple human tumor samples and cell lines suggests that Melk expression is frequently elevated in cancer relative to normal tissues, a pattern confirmed by quantitative reverse transcription-PCR and Western blot 16266996 Human
melk primary tumor An oligonucleotide microarray analysis of multiple human tumor samples and cell lines suggests that Melk expression is frequently elevated in cancer relative to normal tissues, a pattern confirmed by quantitative reverse transcription-PCR and Western blot 16266996 Human
melk tissue tumor In situ hybridization localized Melk expression to malignant epithelial cells in 96%, 23%, and 13% of colorectal, lung, and ovarian tissue tumor samples, respectively. 16266996 Human
melk tumor To begin addressing whether Melk is relevant for tumorigenesis, RNA interference-mediated silencing within human and murine tumor cell lines was done. 16266996 Human
melk tumor We show that Melk knockdown decreases proliferation and anchorage-independent growth in vitro as well as tumor growth in a xenograft model. 16266996 Human
melk tumorigenesis To begin addressing whether Melk is relevant for tumorigenesis, RNA interference-mediated silencing within human and murine tumor cell lines was done. 16266996 Human

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