IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MICA Ensembl ENSG00000204520 Chromosome 6 Start 31475540 End 31491995
Description MHC class I polypeptide-related sequence A [Source:UniProtKB/TrEMBL;Acc:Q5SS58]

< Top >


Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
down 6/17(35%, AD), 5/23(22%,SCC) IHC- 16454647 Hum Gene Ther. 2006 Feb;17(2):135-46.

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40755_at  -0.64  2.74e-3  7.63e-3  -1.01  4.19e-5  1.83e-4
 HG_U133A  205904_at  -0.39  5.09e-6  1.22e-5  -1.64  1.18e-28  1.94e-28
 HG_U133A  205905_s_at  -0.33  9.66e-7  2.49e-6  -1.88  1.47e-60  4.02e-60
 HG_U133_Plus2  205904_at  -0.68  2.04e-11  1.77e-10  -0.74  2.59e-11  1.33e-10
 HG_U133_Plus2  205905_s_at  -0.42  1.54e-7  7.93e-7  -0.43  1.33e-5  3.36e-5
 Stanford  19938  -0.98  1.29e-5  8.45e-4  -1.32  1.00e-2  6.90e-2
 Agilent_HS_21.6K  8269  -0.18  2.52e-3  1.60e-2  -0.16  2.40e-3  1.11e-2

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205904_at  -0.25  2.98e-1  8.75e-1  -0.01  9.49e-1  1.00e+0
 HG_U133A  205905_s_at  -0.26  2.90e-1  8.74e-1  -0.11  4.22e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40755_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205904_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205905_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205904_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205905_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19938    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8269    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
the mica gene skin cancer We therefore specifically addressed the possible association between MICA 5.1 homozygosity and skin cancer, as these individuals are expected to be at the highest risk for skin cancer if the MICA gene plays a role in skin carcinogenesis. 11918717 Human
the mica gene crohn's disease Therefore, we have analysed the MICA exon 5 polymorphism, the MICB intron 1 dinucleotide polymorphism and in addition the tetranucleotide polymorphism C1-4-1, which is located between the MICA gene and the HLA-B gene, in patients of Caucasoid origin with 11782275 Human
the mica gene tumor Hence, we conclude that NF-kappaB regulates MICA expression on activated T lymphocytes and HeLa tumor cells, by binding to a specific sequence in the long intron 1 of the MICA gene. 15494508 Human
mica tumors The Ad5IL-12 vector treatment also induced killing of MICA/B-negative MHC class I-positive PC3 tumors formed in NOD.scid mice. 17332360 Human
mica cervical cancer Association of polymorphic extracellular domains of MICA with cervical cancer in northeastern Thai population. 17389016 Human
mica tumour Previous studies observed aberrant HLA expression patterns on HNSCC tumour cells and this study focused on the allelic polymorphism of HLA genes and the MHC class I chain related gene A (MICA) and HNSCC. 16857416 Human
mica hnscc Previous studies observed aberrant HLA expression patterns on HNSCC tumour cells and this study focused on the allelic polymorphism of HLA genes and the MHC class I chain related gene A (MICA) and HNSCC. 16857416 Human
mica multiple myeloma Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. 17218152 Human
mica tumor The highly polymorphic major histocompatibility class I related chain A (MICA) gene encodes glycoproteins that have been shown to be expressed in epithelial cells, endothelial cells, keratinocytes, monocytes, and tumor cells. 11916168 Human
mica nonmelanoma skin cancer To evaluate the possible association of MICA gene polymorphism with the risk for nonmelanoma skin cancer we evaluated 153 cases with squamous cell carcinoma, 261 cases with basal cell carcinoma, 111 controls with malignant melanoma, and 247 controls witho 11918717 Human
mica nonmelanoma skin cancer Therefore, we conclude that an association between MICA gene polymorphism and nonmelanoma skin cancer is not likely. 11918717 Human
mica epithelial tumours Human major histocompatibility complex class I chain-related A (MICA) is a human leucocyte antigen-related polymorphic molecule, which is expressed on many kinds of epithelial tumours and can be recognized by the Vdelta1 subset of gammadelta T cells. 12869143 Human
mica colonic tumour It was found that MICA was expressed on ovarian and colonic tumour tissues and could be detected by these anti-MICA MoAbs. 12869143 Human
mica rectal tumors Quantitative RT-PCR analysis from rectal tumors revealed that the overall expression of MICA at mRNA level differs extensively among individual tumors. 12894536 Human
mica rectal tumors In addition, invasive rectal tumors tend to up-regulate MICA whereas MICA mRNA levels were lower in early tumors. 12894536 Human
mica rectal carcinomas Differential transcription levels of MICA gene expression in rectal carcinomas at different stages is probably a strategy by tumors to escape confrontation with intraepithelial tumor-infiltrating T cells. 12894536 Human
mica thymomas In thymomas, an overexpression of MICA in cortical and medullar epithelial cells was observed. 12902493 Human
mica gastric cancer The MICA polymorphism was studied in our gastric cancer patients to see if there is any possible correlation with genetic predisposition and clinicopathological factors. 15150599 Human
mica t-all In contrast the NK-sensitive T-ALL (MOLT-4) expressed moderate amounts of MHC class I chain-related gene AB (MICA/B) a ligand for the NK cell activating receptor NKG2D, while expression of MICA/B was absent in resistant B-ALL cell lines. 15730858 Human
mica monoclonal gammopathy of undetermined significance MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes. 16103105 Human
mica hematopoietic tumors T-cell receptor (TCR)-mediated effector functions of gammadelta cells are enhanced upon triggering of the activating receptor NKG2D by MICA, a stress-inducible antigen expressed by epithelial and some hematopoietic tumors, including multiple myeloma. 16103105 Human
mica monoclonal gammopathy of undetermined significance Here we show that MICA was expressed not only by myeloma cell lines and by 6 of 10 primary multiple myeloma cells from patients but also by bone marrow plasma cells from all (six of six) patients with preneoplastic gammopathy (monoclonal gammopathy of und 16103105 Human
mica mgus Moreover, compared with multiple myeloma plasma cells, MICA was expressed by MGUS plasma cells at significantly (P < 0.05) higher levels. 16103105 Human
mica multiple myeloma MICA expressed by myeloma cell lines contributed to killing and IFN-gamma production by Vgamma9/Vdelta2 cells only upon pamidronate treatment, suggesting a dual interaction between Vgamma9/Vdelta2 lymphocytes and multiple myeloma plasma cells involving bo 16103105 Human
mica myeloma MICA expressed by myeloma cell lines contributed to killing and IFN-gamma production by Vgamma9/Vdelta2 cells only upon pamidronate treatment, suggesting a dual interaction between Vgamma9/Vdelta2 lymphocytes and multiple myeloma plasma cells involving bo 16103105 Human
mica colorectal cancer Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients. 16184547 Human
mica colorectal tumors In our study, 449 colorectal tumors were screened for expression of the stress-related protein MICA, which functions as a ligand for the NKG2D receptor and whose expression confers susceptibility to both T- and NK-cell attack. 16184547 Human
mica tumorinfiltrating lymphocytes [Cytotoxicity of MICA-reactive V delta 1 gamma delta T cells towards epithelial tumor cells] OBJECTIVE: To confirm whether human MHC class I chain-related A (MICA) induces the amplification of V delta 1 gamma delta tumor-infiltrating lymphocytes (TILs) in 15052765 Human
mica lymph node metastasis A significant increased MICA RNA expression in tumour tissues compared to healthy surrounding tissue and a significant decreased HSD17B8 RNA in tumour tissues compared to surrounding healthy tissue, particular in those tumours without lymph node metastasi 16750857 Human
mica cml A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal overexpression of major histocompatibility class I chain-related gene A or gene B (MICA/B) on CML CD34 cells and their ability to bind the NK activation ligand NKG2D. 16046526 Human
mica adenosquamous carcinoma We analyzed the MICA polymorphism in 110 cervical cancer cases (88 squamous cell carcinoma, 12 adenocarcinoma and 10 adenosquamous carcinoma) and 82 randomly selected unrelated controls from 1994 to 2000 in the Mackay Memorial Hospital, Taipei, Taiwan. 16151576 Human
mica cancer PURPOSE: As a first step for the development of a new cancer immunotherapy strategy, we evaluated whether antibody-mediated coating by MHC class I-related chain A (MICA) could sensitize tumor cells to lysis by natural killer (NK) cells. 16243826 Human
mica tumor PURPOSE: As a first step for the development of a new cancer immunotherapy strategy, we evaluated whether antibody-mediated coating by MHC class I-related chain A (MICA) could sensitize tumor cells to lysis by natural killer (NK) cells. 16243826 Human
mica uveal melanoma CONCLUSIONS: We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma. 16379028 Human
mica tumor Proteolytic shedding of both NKG2D ligands MICA and ULBP2 by tumor cells was strongly enhanced after phorbol 12-myristate 13-acetate treatment and paralleled by a markedly reduced susceptibility to NKG2D-mediated cytotoxicity. 16510567 Human
mica chronic myeloid leukemia In chronic myeloid leukemia, a malignancy caused by the BCR/ABL fusion oncoprotein, we showed cell surface expression of MICA on leukemic, but not healthy, donor hemopoietic CD34+ cells. 16585609 Human
mica malignancy In chronic myeloid leukemia, a malignancy caused by the BCR/ABL fusion oncoprotein, we showed cell surface expression of MICA on leukemic, but not healthy, donor hemopoietic CD34+ cells. 16585609 Human
mica thyroid cancer It is not known whether MICA/B expression is up-regulated in thyroid cancer as a result of oncogene activation. 16621903 Human
mica thyroid cancer Methods: MICA/B expression in thyroid cancer was analyzed by immunohistochemical staining. 16621903 Human
mica anaplastic thyroid carcinomas Results: MICA/B was expressed at moderate or high levels in 18 of 39 papillary thyroid carcinomas and four of eight anaplastic thyroid carcinomas. 16621903 Human
mica papillary thyroid carcinomas Results: MICA/B was expressed at moderate or high levels in 18 of 39 papillary thyroid carcinomas and four of eight anaplastic thyroid carcinomas. 16621903 Human
mica thyroid cancer Conclusion: MICA/B expression is up-regulated in thyroid cancer, probably due to the activation of the MAPK pathway. 16621903 Human
mica malignant gliomas Thus, escape from NKG2D-mediated immune surveillance of malignant gliomas in vivo may be promoted by the inhibition of MICA and ULBP2 expression via an autocrine TGF-beta loop and by MP-dependent shedding from the cell surface. 16891318 Human
mica malignant glioma Loss of MICA and ULBP2, in contrast to other NKG2DL, may be particularly important in glioma immune escape, and differential regulation of human NKG2DL expression is part of the immunosuppressive properties of human malignant glioma cells. 16891318 Human
mica astrocytoma However, an astrocytoma cell line, U373, which has a full-length variant of MICA, showed that the expression of MICA was decreased after HCMV infection. 15728525 Human
mica leukemia A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal overexpression of major histocompatibility class I chain-related gene A or gene B (MICA/B) on CML CD34 cells and their ability to bind the NK activation ligand NKG2D. 16046526 Human
mica tumor-associated antigens EXPERIMENTAL DESIGN: Recombinant MICA (rMICA) was chemically conjugated to Fab' fragments from monoclonal antibodies specific for tumor-associated antigens, such as carcinoembryonic antigen, HER2, or CD20. 16243826 Human
mica non-small cell lung cancer In this study we explore the potential of genetic overexpression of human major histocompatibility complex class I chain-related gene A (MICA), a powerful NKG2D ligand, for the induction of NK cell-mediated antitumor immunity in a humanized murine model o 16454647 Human
mica lung cancer Our data demonstrate that MICA overexpression can function as NK cell-mediated immunotherapy in experimental lung cancer. 16454647 Human
mica npc This constitutes the first demonstration of a gender-specific association between MICA-STR polymorphism and NPC, which could largely be attributable to the underlying gender-related mechanisms that modulate MICA gene expression. 16547745 Human
mica oncoprotein In chronic myeloid leukemia, a malignancy caused by the BCR/ABL fusion oncoprotein, we showed cell surface expression of MICA on leukemic, but not healthy, donor hemopoietic CD34+ cells. 16585609 Human
mica oncogenes Transient transfection of mutant BRAF and RAS oncogenes led to increased MICA/B expression in 293 cells and WRO82 cells. 16621903 Human
mica gastrointestinal tumors Intestinal cells express MHC related molecules termed MICA/MICB, which are up-regulated under stress and in many gastrointestinal tumors. 16929491 Human
mica oral cancer Material and methods: We used RT-PCR to analyze the mRNA expression of MICA and MICB in four oral cancer cell lines compared with three normal human oral keratinocyte (NHOK) cell lines and in tissues from 36 patients with OSCC comparing tumor tissue with 17181741 Human
mica lymph node metastasis Lastly, the frequency of the MICA-A5.1 allele was significantly higher in those with lymph node metastasis from OSCC compared with normal controls (OR 2.605, 95% CI 1.14-5.27, P=0.026). 17559497 Human
mica isolated metastases Here we demonstrate that several human melanomas (cell lines and freshly isolated metastases) do not express MICA on the cell surface but have intracellular deposits of this NKG2DL. 18354183 Human
mica mds NKG2D ligands (MICA and MICB) were expressed on CD34(+) cells from bone marrow of 30% of MDS patients and a leukemic cell line derived from an MDS patient (MDS1). 17341666 Human
mica tumour These results uncover a molecular mechanism whereby domain-specific deconstruction regulates MICA protein shedding, thereby promoting tumour immune evasion, and identify surface ERp5 as a strategic target for therapeutic intervention. 17495932 Human
mica oral squamous cell carcinoma An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients. 17559497 Human
mica oral squamous cell carcinoma (oscc) An association between MICA gene polymorphisms and the development of oral squamous cell carcinoma (OSCC) has also been reported. 17559497 Human
mica breast cancer In the present study this antibody was used to undertake a definitive study of 530 breast cancer cases with mean follow up of 7 years to determine the prognostic significance of MICA expression. 17948965 Human
mica tumour Univariate analysis showed significant relationships between MICA expression and histological grade (P = 0.006), lymph node stage (P = 0.013), Nottingham Prognostic Index (NPI, P = 0.002), the presence of vascular invasion (P = 0.045) and tumour type (P = 17948965 Human
mica tumours Upregulation of MICA was more often found in histological grade 3, poor prognosis (NPI >5.4) tumours. 17948965 Human
mica necrosis Our results suggest that induced expression of MICA may be an indicator of poor prognosis in breast carcinoma and is indicative of a tumour environment that has undergone stresses such as apoptosis, necrosis, or hypoxia. 17948965 Human
mica tumour Our results suggest that induced expression of MICA may be an indicator of poor prognosis in breast carcinoma and is indicative of a tumour environment that has undergone stresses such as apoptosis, necrosis, or hypoxia. 17948965 Human
mica breast carcinoma Our results suggest that induced expression of MICA may be an indicator of poor prognosis in breast carcinoma and is indicative of a tumour environment that has undergone stresses such as apoptosis, necrosis, or hypoxia. 17948965 Human
mica hcc However, NKG2D receptor could deliver a costimulatory signal enhancing the lysis of HCC and CRC tumors expressing MICA/B. 17764010 Human
mica tumors However, NKG2D receptor could deliver a costimulatory signal enhancing the lysis of HCC and CRC tumors expressing MICA/B. 17764010 Human
mica osteosarcoma [Expression of membrane/soluble MHC class I chain-related molecule A and NKG2D receptor in osteosarcoma and its clinical significance] OBJECTIVE: To study the expression of membrane MICA (mMICA), soluble MICA (sMICA) and NKG2D receptor in cases of osteosa 18070447 Human
mica osteosarcoma Manipulation of the MICA-NKG2D pathway may become a target of immunotherapy for osteosarcoma. 18070447 Human
mica carcinomas The self-encoded ligands MICA (human) and Rae-1 (mouse) for the cytotoxic lymphocyte activating receptor NKG2D are highly expressed in carcinomas and inflammatory lesions and have been linked to immunosurveillance and graft rejection. 18176566 Human
mica mgus MICA expression is increased on plasma cells from MGUS patients compared with normal donors, whereas MM patients display intermediate MICA levels and a high expression of ERp5, a protein disulfide isomerase linked to MICA shedding (sMICA). 18202175 Human
mica cervical cancer Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions. 18208618 Human
mica epithelial tumors Increased serum levels of MICA have been found in patients with epithelial tumors. 18208618 Human
mica cervical cancer The aim of this study was to compare the levels of soluble MICA (sMICA) and NKG2D-expressing NK and T cells in blood samples from patients with cervical cancer or precursor lesions with those from healthy donors. 18208618 Human
mica tumor To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with (99m)Tc ( 18249063 Human
mica ovarian epithelial carcinoma To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with (99m)Tc ( 18249063 Human
mica tumor These results suggest that MICA is a promising target for tumor imaging and mAb 10C6 may be used clinically for early tumor diagnosis. 18249063 Human
mica human osteosarcoma Expression and roles of MICA in human osteosarcoma. 18312344 Human
mica fresh tumour The mRNA and protein expression of NKG2D ligands, MHC class I-related chain molecules A (MICA) and UL16-binding proteins (ULBPs), in human laryngeal carcinoma cell line Hep-2 and fresh tumour tissues were evaluated. 18312485 Human
mica laryngeal carcinoma The mRNA and protein expression of NKG2D ligands, MHC class I-related chain molecules A (MICA) and UL16-binding proteins (ULBPs), in human laryngeal carcinoma cell line Hep-2 and fresh tumour tissues were evaluated. 18312485 Human
mica tumour Compared with non-tumour tissues of vocal cords polyps, MICA and ULBP-3 were strongly overexpressed on both the human laryngeal carcinoma cell line Hep-2 and fresh human laryngeal carcinoma tissues. 18312485 Human
mica polyps Compared with non-tumour tissues of vocal cords polyps, MICA and ULBP-3 were strongly overexpressed on both the human laryngeal carcinoma cell line Hep-2 and fresh human laryngeal carcinoma tissues. 18312485 Human
mica laryngeal carcinoma Compared with non-tumour tissues of vocal cords polyps, MICA and ULBP-3 were strongly overexpressed on both the human laryngeal carcinoma cell line Hep-2 and fresh human laryngeal carcinoma tissues. 18312485 Human
mica tumor CONCLUSION: Among the 6 human NKG2D ligands, the expression of MICA is most intimate to the cytotoxicity of NK cells to tumor cells, and its expression level may determine the degree of immune response of NK cells to tumor. 18334111 Human
mica human osteosarcoma The aim of the study was to investigate the expression and release of MICA in human osteosarcoma. 18348660 Human
mica osteosarcoma Our data showed that MICA is prevalently expressed in osteosarcoma both in mRNA and protein level. 18348660 Human
mica osteosarcoma Upregulation of MICA was found in osteosarcoma compared with benign tumors and normal bone tissues. 18348660 Human
mica benign tumors Upregulation of MICA was found in osteosarcoma compared with benign tumors and normal bone tissues. 18348660 Human
mica osteosarcoma In conclusion, prevalent expression of MICA and higher serum level of soluble MICA may suggest a deficiency of MICA-NKG2D mediated immunosurveillance in osteosarcoma patients. 18348660 Human
mica tumors Most tumors grow in immunocompetent hosts despite expressing NKG2D ligands (NKG2DLs) such as the MHC class I chain-related genes A and B (MICA/B). 18354183 Human
mica melanomas Here we demonstrate that several human melanomas (cell lines and freshly isolated metastases) do not express MICA on the cell surface but have intracellular deposits of this NKG2DL. 18354183 Human
mica melanomas Also, mouse NK cells killed MICA-overexpressing melanomas in vitro. 18354183 Mouse
mica tumor Furthermore, this tumor immune escape strategy can be overcome by gene therapy approaches aimed at overexpressing MICA on tumor cells. 18354183 Human
mica tumor Although MICA expressed on the cell surface stimulates the immunoreceptor natural killer (NK) group 2, member D (NKG2D), the secreted form downregulates NKG2D activity, thus allowing the tumor to escape immunosurveillance by NKG2D-expressing cells. 18361932 Human
mica oral squamous cell carcinoma (oscc) In this study, we examined the association between serum levels of soluble MICA and the severity of disease in patients with oral squamous cell carcinoma (OSCC). 18361932 Human
mica regional lymph node metastasis Patients with stage IV disease and/or regional lymph node metastasis did, however, exhibit significantly higher serum levels of soluble MICA than control individuals (95% confidence interval (CI), 0.65-2.45, p = 0.021, and 95% CI, 0.62-4.42, p = 0.031, re 18361932 Human
mica regional lymph node metastasis Serum levels of soluble MICA may be useful in the diagnosis of advanced stage OSCC and as an indicator of regional lymph node metastasis. 18361932 Human
mica human tumor In the present study, we found that interferon (IFN)-alpha and IFNgamma exert opposing effects on major histocompatibility complex class I-related chain A (MICA) expression in human tumor cells. 18422748 Human
mica malignancy Soluble forms of major histocompatibility complex (MHC) class I-related chain A and B (MICA/B) are increased in the sera of patients with malignancy and impair the antitumor immune response by downregulating expression of their cognate immunoreceptor natu 18754878 Human
mica tumors Recently, soluble MICA/B were reported to appear even in some premalignant diseases, raising questions about the impact of soluble MICA/B produced from tumors on the expression of NKG2D. 18754878 Human
mica hcc The present study examined soluble MICA/B in chronic liver disease and hepatocellular carcinoma (HCC) and their involvement in the immune-cell expression of NKG2D during transcatheter arterial embolization for HCC. 18754878 Human
mica hepatocellular carcinoma (hcc) The present study examined soluble MICA/B in chronic liver disease and hepatocellular carcinoma (HCC) and their involvement in the immune-cell expression of NKG2D during transcatheter arterial embolization for HCC. 18754878 Human
mica hcc Immunohistochemistry revealed that MICA/B were expressed not only in HCC tissue but also on hepatocytes in cirrhotic livers. 18754878 Human
mica hcc In conclusion, although soluble MICA/B are produced from both HCC and premalignant cirrhotic livers, therapeutic intervention for HCC can reduce the levels of soluble MICA and thereby upregulate the expression of NKG2D. 18754878 Human
mica breast tumor [The roles of soluble MICA in immune escape of breast tumor.] AIM: To determine the expression of soluble MICA (sMICA) in serum of patients with breast tumor, and explore the roles of sMICA in immune escape. 18782524 Human
mica oral squamous cell carcinoma An association between MICA gene polymorphisms and the development of oral squamous cell carcinoma (OSCC) has also been reported. 17559497 Human
mica oral squamous cell carcinoma In this study, we examined the association between serum levels of soluble MICA and the severity of disease in patients with oral squamous cell carcinoma (OSCC). 18361932 Human
mica tumor IFNalpha promotes expression of the NKG2D ligand MICA in tumor cells and therefore enhances their sensitivity to natural killer lysis. 18422748 Human
mica hepatoma These low doses increased MICA/B mRNA levels, resulting in an increase of total and cell surface protein expression in hepatoma cells, thus stimulating cytotoxicity and IFN-gamma production of cocultured NK cells. 18519785 Human
mica hepatocellular carcinoma The present study examined soluble MICA/B in chronic liver disease and hepatocellular carcinoma (HCC) and their involvement in the immune-cell expression of NKG2D during transcatheter arterial embolization for HCC. 18754878 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.