IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MUSK Ensembl ENSG00000030304 Chromosome 9 Start 112470960 End 112603099
Description Muscle, skeletal receptor tyrosine protein kinase Precursor (EC 2.7.10.1)(Muscle-specific tyrosine protein kinase receptor)(Muscle-specific kinase receptor)(MuSK) [Source:UniProtKB/Swiss-Prot;Acc:O15146]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7525
     Entrez Gene : 4593
     UCSC : uc004bey.2
     GeneCards : 7525
     RefSeq : NM_001166280
     CCDS : CCDS48005.1
     Uniprot : O15146
     Interpro : O15146
     OMIM : 601296
     GeneTests : MUSK
     CGAP : MUSK
     PMID : 7546737

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
2 0.89 225 1 0.51 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17759 AD c.803C>G p.S268* Substitution - Nonsense Heterozygous 9:112549791-11254979118948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1626_at  0.41  2.52e-2  5.16e-2  0.42  1.17e-1  1.87e-1
 HG_U95  31777_at  0.17  2.67e-1  3.69e-1  0.29  1.77e-1  2.63e-1
 HG_U133A  207632_at  -0.42  3.67e-3  6.14e-3  1.43  2.79e-21  4.13e-21
 HG_U133A  207633_s_at  -0.31  2.98e-3  5.07e-3  3.18  6.92e-88  3.40e-87
 HG_U133_Plus2  207632_at  -0.54  6.07e-3  1.31e-2  -0.16  5.02e-1  5.62e-1
 HG_U133_Plus2  207633_s_at  -0.10  5.65e-1  6.48e-1  0.45  2.80e-2  4.21e-2
 HG_U133_Plus2  241122_s_at  -0.51  3.53e-3  8.07e-3  -0.81  2.55e-5  6.20e-5
 Agilent_HS_21.6K  6284  0.03  2.13e-1  3.90e-1  0.04  8.20e-2  1.79e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207632_at  0.60  3.11e-1  8.79e-1  -0.09  8.12e-1  1.00e+0
 HG_U133A  207633_s_at  -0.53  1.03e-1  7.77e-1  0.30  1.73e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1626_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 31777_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207632_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207633_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207632_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207633_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241122_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6284    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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