IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MYBL2 Ensembl ENSG00000101057 Chromosome 20 Start 41729179 End 41778537
Description Myb-related protein B (B-Myb) [Source:UniProtKB/Swiss-Prot;Acc:P10244]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7548
     Entrez Gene : 4605
     UCSC : uc002xlb.1
     GeneCards : 7548
     RefSeq : NM_002466
     CCDS : CCDS13322.1
     Uniprot : P10244
     Interpro : P10244
     OMIM : 601415
     GeneTests : MYBL2
     CGAP : MYBL2
     PMID : 8812502

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
3 1.51 199 2 1.06 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16678 AD c.392C>A p.P131H Substitution - Missense Heterozygous 20:41749018-4174901818948947
16879 AD c.1198G>T p.G400C Substitution - Missense Heterozygous 20:41764790-4176479018948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1854_at  1.44  2.67e-12  5.31e-11  2.38  1.89e-17  9.94e-16
 HG_U133A  201710_at  1.62  3.69e-20  2.93e-19  4.00  3.24e-81  1.35e-80
 HG_U133_Plus2  201710_at  2.22  2.70e-24  9.98e-23  3.42  6.68e-38  8.80e-36
 Stanford  11378  2.50  1.50e-6  1.94e-4  3.21  2.10e-10  5.06e-7
 Agilent_HS_21.6K  20034  0.21  8.78e-2  2.15e-1  0.46  3.84e-9  1.32e-7

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201710_at  0.37  5.40e-1  9.36e-1  0.18  4.97e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1854_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201710_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201710_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11378    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20034    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mybl2 tumor This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. 12460888 Human
mybl2 tumors Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. 12460888 Human
mybl2 metastases Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. 12460888 Human
mybl2 tumors Of the genes amplified in breast cancer, the BTAK gene was amplified in 21%, the MYBL2 gene in 17%, and the ZNF217 gene in 12.5% of the sporadic tumors. 10815905 Human
mybl2 breast cancer Of the genes amplified in breast cancer, the BTAK gene was amplified in 21%, the MYBL2 gene in 17%, and the ZNF217 gene in 12.5% of the sporadic tumors. 10815905 Human
mybl2 cancer (Cancer Res. 51:3821-3824, 1991) that placed the MYBL2 gene on human chromosome Xq13. 8812502 Human
mybl2 mycosis fungoides Using genomic microarray, we detected oncogene copy number gains of RAF1 (3p25), CTSB (8p22), PAK1 (11q13), and JUNB (19p13) in 5 of 7 cases of mycosis fungoides (MF)/Sezary syndrome (SS) (71%), gains of FGFR1 (8p11), PTPN (20q13), and BCR (22q11) in 4 ca 12393503 Human
bmyb cancer A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. 16150706 Zebrafish
bmyb human tumor Gene-expression signatures associated with loss of bmyb in zebrafish are also correlated with conserved signatures in human tumor samples, and down-regulation of the B-myb signature genes is associated with retention of p53 function. 16150706 Zebrafish
bmyb cancer Our findings show that zebrafish screens can uncover cancer pathways, and demonstrate that loss of function of bmyb is associated with cancer. 16150706 Zebrafish
mybl2 neurofibromatosis 1 Some genes that were not previously linked to this model, such as bric-a-brac (BTB) and cap-n-collar(CNC) homology 1(BACH1), early growth response protein 2 (EGR2), E47 interaction protein 1 (EIP1), Ngfi-A binding protein 2 (NAB2), myeloblastosis oncogene 15182443 Human

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