| lpts |
hepatocellular carcinoma (hcc) |
Recently, a novel liver-related putative tumor suppressor (LPTS), which has a growth inhibitory function in the hepatocellular carcinoma (HCC) cell line, has been identified at chromosome 8p23. |
11867205 |
Human |
| pinx1 |
cancers |
Depletion of PinX1 also increases tumorigenicity in nude mice, consistent with its chromosome localization at 8p23, a region with frequent loss of heterozygosity in a number of human cancers. |
11701125 |
Human |
| pinx1 |
primitive neuroectodermal tumors (pnets) |
We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi |
14750185 |
Human |
| pinx1 |
tumors |
Transcript expression of PinX1, as evaluated by reverse transcription-polymerase chain reaction, in microdissected tumors and normal cerebellum showed 2 transcript variants, corresponding to the full-length form and an alternative spliced variant lacking |
14750185 |
Human |
| lpts |
tumor |
The gene for LPTS/PinX1 encodes a potent telomerase inhibitor and suppresses tumor cell growth. |
14984932 |
Human |
| pinx1 |
tumor |
The gene for LPTS/PinX1 encodes a potent telomerase inhibitor and suppresses tumor cell growth. |
14984932 |
Human |
| lpts |
hepatocellular carcinoma |
AIM: To find the point mutations meaningful for inactivation of liver-related putative tumor suppressor gene (LPTS) gene, a human novel liver-related putative tumor suppressor gene and telomerase inhibitor in hepatocellular carcinoma. |
12508358 |
Human |
| lpts |
liver cancer |
METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 |
12508358 |
Human |
| lpts |
tumor |
METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 |
12508358 |
Human |
| lpts |
ovarian cancer |
METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 |
12508358 |
Human |
| lpts |
hcc |
The expression of the gene for LPTS was ubiquitous in normal human tissues, albeit at relatively low levels, whereas levels appeared to be significantly reduced, or sometimes undetectable in HCC cells and neoplastic tissues. |
11003615 |
Human |
| lpts |
hcc |
Indeed, we observed the significant suppression of growth and growth arrest of SMMC-7721 HCC cells after introduction of the gene for LPTS. |
11003615 |
Human |
| lpts |
hcc |
To determine the relationship of the LPTS with the development or progression of HCC, we analyzed the genetic alterations and the expression pattern of the LPTS gene in a series of 80 HCCs, six dysplastic nodules, and eight large regenerating nodules, det |
11867205 |
Human |
| lpts |
hcc |
In the genetic alteration study of the LPTS gene, no mutation was detected in the large regenerating nodules, dysplastic nodules, and HCC, whereas ten (34.5%) of 29 informative cases at one or more intragenic polymorphic sites showed loss of heterozygosit |
11867205 |
Human |
| lpts |
hcc |
Interestingly, LOH was identified only in HCC samples with hepatitis B virus (HBV) infection and the frequency of LOH was not statistically related with histologic grade and clinical stage, suggesting that allelic loss of the LPTS gene may occur as an ear |
11867205 |
Human |
| lpts |
hcc |
The expression of LPTS gene was ubiquitous in normal human tissues, whereas levels appeared to be significantly reduced, or sometime undetectable in HCC cells and neoplastic tissues, and it might be involved in the negative regulation of cell proliferatio |
12561469 |
Human |
| lpts |
neck tumor |
METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 |
12508358 |
NA |
| lpts |
hcc |
METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 |
12508358 |
NA |
| lpts |
hcc |
LPTS mutations occur in HCC but are infrequent and of little effect on the telomerase inhibitory function of the protein. |
12508358 |
Human |
| pinx1 |
medulloblastomas |
Molecular analysis of PinX1 in medulloblastomas. |
14750185 |
Human |
| pinx1 |
medulloblastomas |
The aim of our study was to investigate whether PinX1, a newly identified gene whose product is a potent inhibitor of telomerase, is the target gene in the homozygous deletion region identified in medulloblastomas. |
14750185 |
Human |
| pinx1 |
medulloblastomas |
We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi |
14750185 |
Human |
| pinx1 |
medulloblastoma |
We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi |
14750185 |
Human |
| pinx1 |
medulloblastomas |
This result indicated that PinX1 expression was not suppressed in medulloblastomas. |
14750185 |
Human |
| pinx1 |
medulloblastomas |
There is no significant correlation between PinX1 transcript expression and telomerase activity, but our results showed that telomerase activation is involved in medulloblastomas. |
14750185 |
Human |
| pinx1 |
medulloblastomas |
Taken together, our results suggest that PinX1 does not play a major role in the oncogenesis of medulloblastomas. |
14750185 |
Human |
| pinx1 |
cancer |
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12). |
15181449 |
Human |
| pinx1 |
prostate cancer |
The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. |
15264240 |
Human |
| pinx1 |
hereditary prostate cancer (hpc) |
METHODS: PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. |
15264240 |
NA |
| pinx1 |
carcinoma |
Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. |
15010887 |
Human |
| pinx1 |
carcinomas |
This study investigated aberrations of PinX1 gene in gastrointestinal tract carcinomas (GITCs). |
15010887 |
NA |
| pinx1 |
human hepatocellular carcinoma |
Molecular analysis of PinX1 in human hepatocellular carcinoma. |
15375513 |
Human |
| pinx1 |
hepatocellular carcinomas |
PinX1 is located at 8p23, a region with frequent loss of heterozygosity in hepatocellular carcinomas (HCCs). |
15375513 |
Human |
| pinx1 |
gastric carcinoma |
Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. |
15637589 |
Human |
| pinx1 |
cancers |
The expression of PINX1, a possible telomerase inhibitor and a putative tumor suppressor, has not been studied in human cancers, including gastric cancer (GC). |
15637589 |
Human |
| pinx1 |
gastric cancer (gc) |
The expression of PINX1, a possible telomerase inhibitor and a putative tumor suppressor, has not been studied in human cancers, including gastric cancer (GC). |
15637589 |
Human |
| pinx1 |
tumor |
Reduced expression (tumor vs normal ratio<0.5) of PINX1 was detected in 50 (68.5%) of 73 cases of GC. |
15637589 |
Human |
