IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PINX1 Ensembl ENSG00000222581 Chromosome 9 Start 12290266 End 12290451
Description U2 spliceosomal RNA [Source:RFAM;Acc:RF00004]

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.50 200 1 0.53 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17746 AD c.633G>T p.R211S Substitution - Missense Heterozygous 8:10660675-1066067518948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  223907_s_at  -0.08  2.35e-1  3.17e-1  0.11  1.23e-1  1.62e-1
 Agilent_HS_21.6K  10369  0.06  2.06e-3  1.36e-2  0.11  3.44e-4  2.23e-3

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 223907_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10369    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lpts hepatocellular carcinoma (hcc) Recently, a novel liver-related putative tumor suppressor (LPTS), which has a growth inhibitory function in the hepatocellular carcinoma (HCC) cell line, has been identified at chromosome 8p23. 11867205 Human
pinx1 cancers Depletion of PinX1 also increases tumorigenicity in nude mice, consistent with its chromosome localization at 8p23, a region with frequent loss of heterozygosity in a number of human cancers. 11701125 Human
pinx1 primitive neuroectodermal tumors (pnets) We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi 14750185 Human
pinx1 tumors Transcript expression of PinX1, as evaluated by reverse transcription-polymerase chain reaction, in microdissected tumors and normal cerebellum showed 2 transcript variants, corresponding to the full-length form and an alternative spliced variant lacking 14750185 Human
lpts tumor The gene for LPTS/PinX1 encodes a potent telomerase inhibitor and suppresses tumor cell growth. 14984932 Human
pinx1 tumor The gene for LPTS/PinX1 encodes a potent telomerase inhibitor and suppresses tumor cell growth. 14984932 Human
lpts hepatocellular carcinoma AIM: To find the point mutations meaningful for inactivation of liver-related putative tumor suppressor gene (LPTS) gene, a human novel liver-related putative tumor suppressor gene and telomerase inhibitor in hepatocellular carcinoma. 12508358 Human
lpts liver cancer METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 12508358 Human
lpts tumor METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 12508358 Human
lpts ovarian cancer METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 12508358 Human
lpts hcc The expression of the gene for LPTS was ubiquitous in normal human tissues, albeit at relatively low levels, whereas levels appeared to be significantly reduced, or sometimes undetectable in HCC cells and neoplastic tissues. 11003615 Human
lpts hcc Indeed, we observed the significant suppression of growth and growth arrest of SMMC-7721 HCC cells after introduction of the gene for LPTS. 11003615 Human
lpts hcc To determine the relationship of the LPTS with the development or progression of HCC, we analyzed the genetic alterations and the expression pattern of the LPTS gene in a series of 80 HCCs, six dysplastic nodules, and eight large regenerating nodules, det 11867205 Human
lpts hcc In the genetic alteration study of the LPTS gene, no mutation was detected in the large regenerating nodules, dysplastic nodules, and HCC, whereas ten (34.5%) of 29 informative cases at one or more intragenic polymorphic sites showed loss of heterozygosit 11867205 Human
lpts hcc Interestingly, LOH was identified only in HCC samples with hepatitis B virus (HBV) infection and the frequency of LOH was not statistically related with histologic grade and clinical stage, suggesting that allelic loss of the LPTS gene may occur as an ear 11867205 Human
lpts hcc The expression of LPTS gene was ubiquitous in normal human tissues, whereas levels appeared to be significantly reduced, or sometime undetectable in HCC cells and neoplastic tissues, and it might be involved in the negative regulation of cell proliferatio 12561469 Human
lpts neck tumor METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 12508358 NA
lpts hcc METHODS: The entire coding sequence of LPTS gene was examined for mutations by single strand conformation polymorphism (SSCP) assay and PCR products direct sequencing in 56 liver cancer cell lines, 7 ovarian cancer and 7 head neck tumor cell lines and 70 12508358 NA
lpts hcc LPTS mutations occur in HCC but are infrequent and of little effect on the telomerase inhibitory function of the protein. 12508358 Human
pinx1 medulloblastomas Molecular analysis of PinX1 in medulloblastomas. 14750185 Human
pinx1 medulloblastomas The aim of our study was to investigate whether PinX1, a newly identified gene whose product is a potent inhibitor of telomerase, is the target gene in the homozygous deletion region identified in medulloblastomas. 14750185 Human
pinx1 medulloblastomas We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi 14750185 Human
pinx1 medulloblastoma We assessed for alterations in gene sequence and transcript expression of PinX1, as well as the correlation between PinX1 expression and telomerase activity in a series of 52 medulloblastomas, 3 medulloblastoma cell lines (D283, D341 and Daoy) and 4 primi 14750185 Human
pinx1 medulloblastomas This result indicated that PinX1 expression was not suppressed in medulloblastomas. 14750185 Human
pinx1 medulloblastomas There is no significant correlation between PinX1 transcript expression and telomerase activity, but our results showed that telomerase activation is involved in medulloblastomas. 14750185 Human
pinx1 medulloblastomas Taken together, our results suggest that PinX1 does not play a major role in the oncogenesis of medulloblastomas. 14750185 Human
pinx1 cancer Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12). 15181449 Human
pinx1 prostate cancer The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. 15264240 Human
pinx1 hereditary prostate cancer (hpc) METHODS: PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. 15264240 NA
pinx1 carcinoma Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma. 15010887 Human
pinx1 carcinomas This study investigated aberrations of PinX1 gene in gastrointestinal tract carcinomas (GITCs). 15010887 NA
pinx1 human hepatocellular carcinoma Molecular analysis of PinX1 in human hepatocellular carcinoma. 15375513 Human
pinx1 hepatocellular carcinomas PinX1 is located at 8p23, a region with frequent loss of heterozygosity in hepatocellular carcinomas (HCCs). 15375513 Human
pinx1 gastric carcinoma Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. 15637589 Human
pinx1 cancers The expression of PINX1, a possible telomerase inhibitor and a putative tumor suppressor, has not been studied in human cancers, including gastric cancer (GC). 15637589 Human
pinx1 gastric cancer (gc) The expression of PINX1, a possible telomerase inhibitor and a putative tumor suppressor, has not been studied in human cancers, including gastric cancer (GC). 15637589 Human
pinx1 tumor Reduced expression (tumor vs normal ratio<0.5) of PINX1 was detected in 50 (68.5%) of 73 cases of GC. 15637589 Human

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