IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PKN3 Ensembl ENSG00000160447 Chromosome 9 Start 130504623 End 130523019
Description Serine/threonine-protein kinase N3 (EC 2.7.11.13)(Protein kinase PKN-beta)(Protein-kinase C-related kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:Q6P5Z2]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17999
     Entrez Gene : 29941
     UCSC : uc004bvw.2
     GeneCards : 17999
     RefSeq : NM_013355
     CCDS : CCDS6908.1
     Uniprot : Q6P5Z2
     Interpro : Q6P5Z2
     OMIM : 610714
     GeneTests : PKN3
     CGAP : PKN3
     PMID : 10441506

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
2 0.89 225 2 1.03 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16608 AD c.2137G>C p.G713R Substitution - Missense Heterozygous 9:130521797-13052179718948947
17286 AD c.920G>T p.S307I Substitution - Missense Heterozygous 9:130515236-13051523618948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  226299_at  -0.71  6.67e-5  2.19e-4  -1.01  8.03e-7  2.38e-6
 Agilent_HS_21.6K  2765  -0.09  2.39e-1  4.21e-1  -0.08  1.99e-1  3.43e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 226299_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2765    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pknbeta cancer Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemic 10441506 Human
pkn3 mouse tumor PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). 15282551 Human
pkn3 cancers Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K. 15282551 Human

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