IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PROS1 Ensembl ENSG00000184500 Chromosome 3 Start 95074643 End 95175416
Description Vitamin K-dependent protein S Precursor [Source:UniProtKB/Swiss-Prot;Acc:P07225]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9456
     Entrez Gene : 5627
     UCSC : uc003drb.3
     GeneCards : 9456
     RefSeq : NM_000313
     CCDS : CCDS2923.1
     Uniprot : P07225
     Interpro : P07225
     OMIM : 176880
     GeneTests : PROS1
     CGAP : PROS1
     PMID : 214811

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  35752_s_at  -1.27  1.25e-14  3.71e-13  -1.43  2.51e-15  8.65e-14
 HG_U133A  207808_s_at  -1.39  3.41e-33  6.49e-32  -6.49  5.06e-99  3.33e-98
 HG_U133_Plus2  207808_s_at  -1.60  8.39e-30  5.69e-28  -1.85  3.32e-24  7.49e-23
 Stanford  158  -1.16  1.06e-2  6.70e-2  -1.53  3.60e-3  3.40e-2
 Agilent_HS_21.6K  12294  -0.41  9.99e-4  7.67e-3  -0.54  1.30e-4  9.90e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207808_s_at  -0.02  9.53e-1  9.98e-1  -0.60  2.16e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 35752_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207808_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207808_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 158    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12294    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
protein s human hepatoma Biosynthesis and secretion of factor VII, protein C, protein S, and the Protein C inhibitor from a human hepatoma cell line. 3000483 Human
protein s leukaemia Thus, there is no clear evidence that reduced levels of protein C and (or) protein S cause thrombosis in leukaemia patients treated with this drug combination. 2946315 Human
protein s breast cancer Chemotherapy for breast cancer decreases plasma protein C and protein S. 2963094 Human
protein s inflammatory bowel disease Deep venous thrombosis, inflammatory bowel disease, and protein S deficiency. 2972196 Human
protein s ibd This occurrence suggests that low Protein S levels should be considered as a potential etiologic factor in patients with IBD and recurrent DVT. 2972196 Human
protein s malignancy Protein S total antigen levels were also found to be low in DIC patients, excluding those with malignancy. 2521800 Human
protein s necrosis Necrosis of skin induced by coumarin in a patient deficient in protein S. 2522326 Human
protein s essential thrombocythemia Low protein S in essential thrombocythemia with thrombosis. 2527003 Human
protein s necrosis Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: report of two cases. 2527005 Human
protein s arteriovenous malformations Multiple arteriovenous malformations of the small intestine in a patient with protein S deficiency. 2528285 Human
protein s arteriovenous malformations The authors report a case of arteriovenous malformations (AVMs) of the small intestine in a young patient with protein S deficiency. 2528285 Human
protein s breast carcinoma 3) The 74 kDa precursor synthesized by colon carcinoma and breast carcinoma was positively identified as a precursor of protein S. 2573164 Human
protein s colon carcinoma 3) The 74 kDa precursor synthesized by colon carcinoma and breast carcinoma was positively identified as a precursor of protein S. 2573164 Human
protein s necrosis Type I protein S deficiency and skin necrosis. 2371192 Human
protein s necrosis A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. 2371192 Human
protein s essential thrombocythemia Level of protein S and essential thrombocythemia. 2144707 Human
protein s nephroblastoma Inferior vena cava thrombosis in a child with nephroblastoma and combined deficiency of antithrombin III and free protein S. 2176901 Human
protein s polycythemia vera Decreased free protein S levels in polycythemia vera. 2148846 Human
protein s necrosis Cutaneous necrosis associated with protein S deficiency. 2149570 Human
protein s glomus tumours We describe 10 patients with cerebral venous thrombosis: two had protein S deficiency, one had protein C deficiency, one was in early pregnancy, and there was a single case of each of the following: dural arteriovenous malformation, intracerebral arteriov 2149767 Human
protein s wegener's granulomatosis We describe 10 patients with cerebral venous thrombosis: two had protein S deficiency, one had protein C deficiency, one was in early pregnancy, and there was a single case of each of the following: dural arteriovenous malformation, intracerebral arteriov 2149767 Human
protein s non-hodgkin's lymphoma We describe 10 patients with cerebral venous thrombosis: two had protein S deficiency, one had protein C deficiency, one was in early pregnancy, and there was a single case of each of the following: dural arteriovenous malformation, intracerebral arteriov 2149767 Human
protein s arteriovenous malformation We describe 10 patients with cerebral venous thrombosis: two had protein S deficiency, one had protein C deficiency, one was in early pregnancy, and there was a single case of each of the following: dural arteriovenous malformation, intracerebral arteriov 2149767 Human
protein s essential thrombocythemia Level of protein S and essential thrombocythemia. 1824610 Human
protein s tumor By contrast, no tissue staining was observed for factor VII, factor X, factor XIII "a" subunit, high-molecular-weight urokinase-type plasminogen activator, plasminogen activator inhibitors 1 to 3, protein C, and protein S. Thus, the similarity i 1703919 Human
protein s prostatic cancer By contrast, no tissue staining was observed for factor VII, factor X, factor XIII "a" subunit, high-molecular-weight urokinase-type plasminogen activator, plasminogen activator inhibitors 1 to 3, protein C, and protein S. Thus, the similarity i 1703919 Human
protein s hyperplastic By contrast, no tissue staining was observed for factor VII, factor X, factor XIII "a" subunit, high-molecular-weight urokinase-type plasminogen activator, plasminogen activator inhibitors 1 to 3, protein C, and protein S. Thus, the similarity i 1703919 Human
protein s acute leukemia Plasma samples from 50 adult patients with acute leukemia (34 AML, 16 ALL) were analyzed for protein C antigen, functional protein C, immunologic total and free protein S as well as levels of C4b binding protein (C4bBP). 1830452 Human
protein s aml Plasma samples from 50 adult patients with acute leukemia (34 AML, 16 ALL) were analyzed for protein C antigen, functional protein C, immunologic total and free protein S as well as levels of C4b binding protein (C4bBP). 1830452 Human
protein s aml Although total protein S levels were normal in all patients studied, levels of free protein S were significantly decreased in patients with active AML (mean = 29.3) compared with patients in remission (mean = 42.0) or controls (mean = 42.4). 1830452 Human
protein s aml This decrease in free protein S seen in active AML was not associated with liver disease, white cell count or an increase in C4bBP. 1830452 Human
protein s necrosis Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency. 1832815 Human
protein s necrosis We report a case of skin necrosis associated with inherited protein S deficiency following prolonged coumarin therapy. 1832815 Human
protein s necrosis As a result of a stasis ulceration causing a rise in c4b binding protein and concurrent treatment with topical sulfonamide, we hypothesize that a precipitous decrease in free protein S led to skin necrosis. 1832815 Human
protein s necrosis This case confirms the rare association between coumarin induced skin necrosis and protein S deficiency and emphasizes potential drug interactions. 1832815 Human
protein s malignant neoplasms Cardiovascular diseases, malignant neoplasms, venous disorders, diseases associated with increased viscosity of blood, past deep-vein thrombosis and pulmonary embolisms, some infectious diseases with raised fibrinogen levels, and inherited or acquired clo 1937369 Human
protein s necrosis Coumadin skin necrosis in a patient with a free protein S deficiency: case report and literature review. 1837041 Human
protein s necrosis The recently described association with low levels of protein C and/or free protein S is of importance in the pathophysiology of coumadin skin necrosis. 1837041 Human
protein s necrosis This article describes the case of a patient with a functional protein S deficiency who developed coumadin skin necrosis. 1837041 Human
protein s necrosis Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis. 1532474 Human
protein s necrosis We report two patients in whom the occurrence of protein S deficiency and subsequent skin necrosis can be related to demonstrated peritoneal dialysis-associated losses. 1532474 Human
protein s pulmonary cancer Because hereditary deficiencies of coagulation inhibitors antithrombin III, protein C and protein S are known to cause thromboembolic events it was the aim of our study to search for acquired alterations of these proteins in pulmonary cancer patients. 1318586 Human
protein s pulmonary carcinoma In contrast, in patients suffering from metastatic pulmonary carcinoma bound protein S was increased, while free protein S was significantly reduced. 1318586 Human
protein s pulmonary cancer In conclusion, the decrease of free protein S is one source for thromboembolic complications in pulmonary cancer patients. 1318586 Human
protein s pancreatic cancer In a group of pancreatic cancer patients with advanced disease, subnormal mean free protein S was found, whereas mean total protein S concentration, and mean C4bBP concentrations were significantly higher (p less than 0.01) than in healthy controls. 1519231 Human
protein s malignancy Thus, acquired protein S deficiencies seem to be one source of thromboembolic complications occurring in nephrotic syndrome, acute phase reactions, malignancy and pregnancy. 1392420 Human
protein s necrosis Warfarin-induced skin necrosis in 2 patients with protein S deficiency: successful reinstatement of warfarin therapy. 1427456 Human
protein s inflammatory bowel disease Free protein S deficiency in patients with chronic inflammatory bowel disease. 1455194 Human
protein s crohn's disease Free protein S, protein C, and C4b-binding protein (C4b-BP) were measured in randomly selected outpatients: 22 with Crohn's disease (CD) and 16 with ulcerative colitis (UC). 1455194 Human
protein s human tumor We have examined the ability of three human tumor cell lines (HepG2, CAPAN-2 and J82) to support the inactivation of human factor Va by human APC in the presence and absence of human protein S. APC-mediated factor Va inactivation on these tumor cell lines 1468718 Human
protein s tumor We have examined the ability of three human tumor cell lines (HepG2, CAPAN-2 and J82) to support the inactivation of human factor Va by human APC in the presence and absence of human protein S. APC-mediated factor Va inactivation on these tumor cell lines 1468718 Human
protein s tumor Although not essential for this reaction, protein S moderately enhanced the rate of factor Va inactivation by APC on these tumor cell lines. 1468718 Human
protein s hematologic malignancies We measured the naturally occurring anticoagulants protein C, antithrombin III, and protein S in 45 patients undergoing bone marrow transplantation for hematologic malignancies before cytoreductive therapy and after transplant. 8507881 Human
protein s neural tumor Protein S, an antithrombotic factor, is synthesized and released by neural tumor cells. 8515282 Human
protein s tumor Protein S, an anticoagulant factor in the protein C antithrombotic pathway, was found to be synthesized and released by six tumor cell lines of neural origin by western blotting and ELISA. 8515282 Human
protein s primary brain tumor Ten primary brain tumor tissues also expressed protein S antigen, as shown by western blot analysis. 8515282 Human
protein s necrosis Cutaneous necrosis associated with acquired severe protein S deficiency. 8068053 Human
protein s osteosarcoma Because protein S is a cofactor of protein C in inhibiting factor Va and VIIIa, we have looked for the presence of the proteins related to the anticoagulant protein C system in human MG 63 osteosarcoma cells and in human adult osteoblast-like cells. 8393772 Human
protein s necrosis In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis. 8403462 Human
protein s necrosis Cutaneous necrosis resulting from protein S deficiency and increased antiphospholipid antibody in a patient with systemic lupus erythematosus. 8408826 Human
protein s necrosis A 23-year-old woman with widespread cutaneous necrosis resulting from protein S deficiency and increased antiphospholipid antibody in the setting of systemic lupus erythematosus is described. 8408826 Human
protein s essential thrombocythemia Platelet hyperactivation in patients with essential thrombocythemia is not associated with vascular endothelial cell damage as judged by the level of plasma thrombomodulin, protein S, PAI-1, t-PA and vWF. 8128427 Human
protein s necrosis Coumarin-induced skin necrosis associated with acquired protein S deficiency and antiphospholipid antibody syndrome. 8024618 Human
protein s hepatoma Tumor necrosis factor-alpha downregulates protein S secretion in human microvascular and umbilical vein endothelial cells but not in the HepG-2 hepatoma cell line. 8025276 Human
protein s human hepatocellular carcinoma However, TNF-alpha showed no regulatory control over protein S synthesis in the human hepatocellular carcinoma cell line HepG-2. 8025276 Human
protein s necrosis Cutaneous necrosis associated with acquired severe protein S deficiency. 8068141 Human
protein s crohn's disease Free protein S deficiency in patients with Crohn's disease. 8047807 Human
protein s hyperplasia Immunohistochemical labelling of PDGF, TNF and IL-1 beta in vascular lesions suggests these factors may trigger intimal vascular smooth muscle cell proliferation in chronically rejecting allografts, as they, along with protein S, were closely associated w 8061372 Human
protein s cancer A cause was identified in 61 cases (50.8%): cancer (n = 24, 17 known, 7 previously unknown), dyscrasia (n = 17, protein S or C deficiency (5), increased plasminogen activator inhibitor I (8), circulating anticoagulants (3), hypofibrinogen (1), idiopathic 7937604 Human
protein s necrosis We started long-term therapy with oral coagulants, i.e. warfarin even if the latter may cause skin necrosis ("warfarin dermatitis") in some patients with protein S deficiency. 7946892 Human
protein s tumor necrosis There was also wide-spread staining for the inflammatory cytokine interleukin-1B (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and IL-8, as well as dense expression of the potent smooth muscle mitogens platelet-derived growth factor (PDGF), transf 7977633 Human
protein s breast cancer To explore the possible procoagulant effects associated with tamoxifen therapy we evaluated changes in protein S and C activity levels in 58 postmenopausal women with surgically resected breast cancer who were disease-free and participating in a double-bl 7981450 Human
protein s apl We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibo 7993940 Human
protein s polycythemia vera For high-risk patients having a history of recurrent venous thromboembolism or which are suffering from a thrombogenic disease (e.g. myeloproliferative disorder, especially polycythemia vera, paroxysmal nocturnal hemoglobinuria, systemic lupus erythematos 7839322 Human
protein s malignancy Potentially predisposing factors for thrombosis in AIDS include central venous catheterization, malignancy, elevated anticardiolipin antibodies, alteration of vascular endothelial cell function reflected in low free protein S levels, and enhanced endothel 7744629 Human
protein s intracranial tumors Other causes included antiphospholipid antibodies in 4, protein S deficiency in 3, intracranial tumors in 3, systemic lupus erythematosus in 3, infections in 3, antithrombin III deficiency in 2, postpartum in 1, and oral contraceptives in 1. 7604412 Human
protein s myeloproliferative disorders This, and the decreased levels of protein C and total protein S, may be secondary to chronic clinically occult thrombosis occurring in myeloproliferative disorders. 7639271 Human
protein s hepatoma As a basis for regulatory studies on the influence of hormones on (anti)coagulant protein production by hepatocytes, we examined the amounts of the plasma proteins antithrombin III (AT III), protein C, protein S, factor II, factor X, fibrinogen, and preal 8585007 Human
protein s hepatoma IL-6 upregulates protein S expression in the HepG-2 hepatoma cells. 7482409 Human
protein s hepatoma We have found that stimulation of HepG-2 hepatoma cells with IL-6 (5 ng/ ml) significantly increased the production of the anticoagulant cofactor, protein S, in both a time and dose dependent fashion. 7482409 Human
protein s murine leukemia We have compared the expression properties of four secreted proteins, the human blood clotting factor IX (FIX), the human blood glycoprotein Protein S (ProtS), the human von Willebrand factor (vWF), and the Hepatitis B virus (HBV) middle surface glycoprot 8535147 Human
protein s multiple myeloma Acquired free protein S deficiency associated with multiple myeloma: a case report. 8602634 Human
protein s multiple myeloma Investigation of recurrent venous thromboembolic events in a 46-year-old man with progressive IgG kappa (total serum IgG, 74.3 mg/ml) multiple myeloma revealed profound reductions in free protein S (PS) antigen (<0.l U/ml) and PS activity (0.33 U/ml). 8602634 Human
protein s malignancy The patient had none of the following risk factors for pulmonary emboli: malignancy, neurological disease, heart disease, obesity, pregnancy, or a congenital coagulative abnormality such as deficiency of AT-III, protein C, protein S, or plasminogen. 8622276 Human
protein s essential thrombocythemia Reduction of antithrombin III, protein C, and protein S levels and activated protein C resistance in polycythemia vera and essential thrombocythemia patients with thrombosis. 8638606 Human
protein s polycythemia vera Reduction of antithrombin III, protein C, and protein S levels and activated protein C resistance in polycythemia vera and essential thrombocythemia patients with thrombosis. 8638606 Human
protein s chronic myeloproliferative disorders For this reason we evaluated protein S (PS) total antigen, antithrombin III (AT III), and protein C (PC) activity in 81 patients with chronic myeloproliferative disorders (33 with PV and 48 with ET). 8638606 Human
protein s hepatoma TNF-alpha suppresses IL-6 upregulation of protein S in HepG-2 hepatoma cells. 8928089 Human
protein s cutaneous t-cell lymphoma Cutaneous T-cell lymphoma, tropical spastic paraparesis, cerebral vasculitis, and protein S deficiency in a patient with HTLV-I. 8865796 Human
protein s cutaneous t-cell lymphoma We report the case of a 35-year-old woman with HTLV-I and the unusual combination of cutaneous T-cell lymphoma, tropical spastic paraparesis, cerebral vasculitis, and protein S deficiency. 8865796 Human
protein s stage-ii breast cancer In plasma samples of 38 patients (median age: 49 years) receiving CMF (schedule 1-21 or 1-8) for Stage II breast cancer, we evaluated: PT, aPTT, antithrombin III (AT-III), protein C (PC), protein S (PS), thrombin-antithrombin complex (TAT), prothrombin fr 8879681 Human
protein s necrosis Warfarin skin necrosis in a postpartum woman with protein S deficiency. 11770590 Human
protein s necrosis CASE: A 1-week postpartum woman with known protein S deficiency presented with skin necrosis after a previously uneventful course of warfarin. 11770590 Human
protein s necrosis CONCLUSION: Reduced levels of free protein S during the antepartum and immediate postpartum periods predispose protein S-deficient women to warfarin skin necrosis. 11770590 Human
protein s hyperplasia [Idiopathic portal hypertension, multiple focal nodular hepatic hyperplasia, the CREST syndrome and protein S deficiency] A 54 year old woman with idiopathic portal hypertension, CREST syndrome, protein "S" deficiency and multiple focal nodular 9090984 Human
protein s ovarian cancer [A case of protein S deficiency associated with ovarian cancer] 9235091 Human
protein s cancer We performed a prospective, multicenter trial (4 thrombosis centers) and evaluated in 380 patients with a first or recurrent VTE (patients with a deficiency of antithrombin, protein C, protein S or plasminogen; cancer; or an antiphospholipid antibody synd 9134632 Human
protein s necrosis Cutaneous heparin necrosis in a patient with heterozygous protein S deficiency. 9169261 Human
protein s necrosis A patient with heterozygous protein S deficiency experienced cutaneous necrosis following subcutaneous heparin administration. 9169261 Human
protein s necrosis Deficiencies of both protein C and protein S, known risk factors for the more frequently encountered coumarin necrosis, may predispose patients to this complication of heparin therapy as well. 9169261 Human
protein s necrosis The putative association of protein S deficiency with cutaneous heparin necrosis could not be proven, however, since attempts to reproduce the heparin necrosis were unsuccessful. 9169261 Human
protein s human hepatoma We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. 9184420 Human
protein s cancer Tested thrombophilic mechanisms were either genetic (activated protein C [APC] resistance; anti-thrombin III deficiency [ATIII]; protein C or protein S deficiency [PC, PS]) or acquired (lupus anti-coagulant [LAC]/anti-cardiolipin antibodies [ACA]; subsequ 9307763 Human
protein s malignancy The aim of the present study was to determine plasma levels of protein C antigen (PC:Ag) and activity (PC:Act), tissue factor pathway inhibitor (TFPI), protein S (PS), antithrombin (AT), heparin cofactor II (HCII), and resistance to activated protein C (A 9483169 Human
protein s breast cancer In contrast to the breast cancer patients, no significant changes in protein C, protein S and antithrombin III levels were observed in the NHL patients during the various stages of therapy. 9600111 Human
protein s cavernous hemangioma We report the first case of a successful cesarean section at term following expectant management of pregnancy in a patient with presumed isolated diffuse cavernous hemangioma of the uterus and protein S deficiency. 9759909 Human
protein s necrosis Recurrent warfarin-induced skin necrosis in kindreds with protein S deficiency. 9885367 Human
protein s necrosis Although protein C deficiency is the most common underlying hypercoagulable state reportedly associated with warfarin skin necrosis, very few cases have been linked to congenital protein S deficiency. 9885367 Human
protein s necrosis This article addresses the association of hereditary protein S deficiency and warfarin skin necrosis, and provides suggestions for management. 9885367 Human
protein s stage-ii breast cancer In 50 consecutive stage II breast cancer patients (pre-peri-postmenopausal), and 50 controls, serial coagulation parameters including prothrombin time (P.T.), partial thromboplastin time (P.T.T.), fibrinogen, fibrinogen/fibrin degradation products (F.D.P. 10629646 Human
protein s malignancy Five patients (10%) were found to have malignancy; an inferior vena cava thrombosis in one patient was due to venous compression by hydronephrosis; two patients had lupus anticoagulant; two had varicose veins of legs; two had protein C deficiency; four ha 10629572 Human
protein s malignancy In conclusion, malignancy and protein S deficiency were the most frequent acquired and congenital causes of venous thrombosis in the Chinese, respectively. 10629572 Human
protein s inflammatory bowel disease Resistance to activated protein C and low levels of free protein S in Greek patients with inflammatory bowel disease. 10638581 Human
protein s ibd Plasma levels of protein C, free protein S, antithrombin III (AT-III), activated protein C resistance (APCR), and fibrinogen were determined in IBD patients, as well as in HC. 10638581 Human
protein s necrosis [Constitutional thrombophilias: indications of the biological profile and therapeutic consequences] In laboratory screening in patients with clinical thrombophilia (early thromboembolism episode < 50 years, spontaneous thrombosis, recurrent thrombosis, un 10667107 Human
protein s myeloproliferative disorders The prothrombotic disorders that were investigated included classical and occult myeloproliferative disorders; antiphospholipid syndrome; protein C; protein S and antithrombin deficiency; factor V Leiden; factor II; and methylene-tetrahydrofolate-reductas 10706547 Human
protein s polycythemia vera BACKGROUND/AIMS: Hepatic vein thrombosis (Budd-Chiari syndrome) is associated with various hypercoagulable states, such as polycythemia vera (PV), presence of the lupus anticoagulant, paroxysmal nocturnal hemoglobinuria (PNH) and deficiencies of antithrom 10782905 Human
protein s chronic lymphocytic leukemia Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency. 10841326 Human
protein s chronic lymphocytic leukemia A patient with chronic lymphocytic leukemia and an undetectable plasma level of protein S (PS), associated with recurrent venous thrombosis, is described. 10841326 Human
protein s inflammatory bowel disease Conditions capable of triggering intravascular coagulation include familial thrombophilia (resistance to activated protein C, decreased protein C, protein S, or antithrombin III, and hyperhomocystinemia), hyperlipemia and embolic lipid (alcoholism and hyp 10875131 Human
protein s ibd Studies looking at the prevalence of specific thrombophilic states such as Antithrombin III deficiency (Jackson et al. 1997; Lake, Stauffer & Stuart 1978; Cianco et al. 1996; Ghosh et al. 1983), Factor V Leiden mutation (APC Resistance) (Jackson et al. 19 11012640 Human
protein s polycythemia vera The patient had deficiencies of protein C, protein S, antithrombin III; was heterozygous for factor V Leiden; and had polycythemia vera. 11104298 Human
protein s necrosis Severe acquired functional protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis. 11127886 Human
protein s cholangiocarcinoma The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s renal-cell carcinoma The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s chronic lymphatic leukemia The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s hepatocellular carcinoma The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s polycythemia rubra vera The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s hydatid cyst The etiopathological nature in 30 cases were as follows: idiopathic membranous obstruction in nine (30%), hepatocellular carcinoma in six (20%), idiopathic stricture in six (20%) cases and one case (3.3%) each of the following: cholangiocarcinoma, renal c 11273472 Human
protein s advanced breast carcinoma METHODS: Cholesterol, triglyceride, low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL), antithrombin III, protein C, protein S, and fibrinogen were serially measured in 21 postmenopausal women with advanced 9921980 Human
protein s necrosis Anticoagulant-induced skin necrosis in a patient with hereditary deficiency of protein S. 10072117 Human
protein s inflammatory bowel disease Conditions capable of triggering intravascular coagulation include familial thrombophilia (resistance to activated protein C, decreased protein C, protein S, or antithrombin III), hyperlipemia and embolic lipid (alcoholism and hypercortisonism), hypersens 10084210 Human
protein s acute lymphoblastic leukemia In this study, protein C (PC), protein S (PS), heparin cofactor II (HCFII), prothrombin fragment 1+2 (PF 1,2), thrombin-antithrombin III complex (TAT), von Willebrand factor (vWF) and thrombomodulin (TM) were investigated in 19 patients with acute lymphob 10221516 Human
protein s phaeochromocytoma Myocardial infarction and death after caesarean section in a woman with protein S deficiency and undiagnosed phaeochromocytoma. 10234500 Human
protein s human lung carcinoma Synthesis and secretion of the anticoagulant protein S and coexpression of the Tyro3 receptor in human lung carcinoma cells. 10391562 Human
protein s tumor This lends support to the hypothesis that protein S might also be involved in tumor cell regulation. 10391562 Human
protein s lung carcinoma METHODS: The expression of protein S and receptor Tyro3 was examined in 22 lung carcinoma cell lines and normal bronchial epithelial cells by reverse transcriptase-polymerase chain reaction. 10391562 Human
protein s small cell lung carcinoma (sclc) RESULTS: Protein S mRNA and secreted protein were found in 11 of 12 cell lines of nonsmall cell lung carcinoma (NSCLC) origin and in normal bronchial epithelial cells, but they were found in only 4 of 10 small cell lung carcinoma (SCLC) cell lines. 10391562 Human
protein s nonsmall-cell lung carcinoma (nsclc) RESULTS: Protein S mRNA and secreted protein were found in 11 of 12 cell lines of nonsmall cell lung carcinoma (NSCLC) origin and in normal bronchial epithelial cells, but they were found in only 4 of 10 small cell lung carcinoma (SCLC) cell lines. 10391562 Human
protein s lung carcinoma The majority of lung carcinoma cell lines that expressed protein S (13 of 15) also revealed expression of the cognate receptor, Tyro3. 10391562 Human
protein s lung tumor In lung tumor tissue, protein S antigen was found in 20 of 31 cases examined, predominantly in tumors of the squamous cell and bronchioalveolar cell types. 10391562 Human
protein s tumors In lung tumor tissue, protein S antigen was found in 20 of 31 cases examined, predominantly in tumors of the squamous cell and bronchioalveolar cell types. 10391562 Human
protein s tumor Protein S was found not only in tumor cells but also in cells of the normal bronchial epithelium, in alveolar macrophages, and in endothelium. 10391562 Human
protein s lung tumor It suggests that protein S, by binding to a receptor (Tyro3), may influence local anticoagulation events or other, as yet unidentified, aspects of lung tumor development. 10391562 Human
protein s necrosis [Recurrent coumarin necrosis in type II protein S deficiency] Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. 11284095 Human
protein s necrosis We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. 11284095 Human
protein s inflammatory bowel disease Reduced free protein S levels in patients with inflammatory bowel disease: prevalence, clinical relevance, and role of anti-protein S antibodies. 11318545 Human
protein s ibd We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory b 11318545 Human
protein s inflammatory bowel disease We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory b 11318545 Human
protein s ibd Mean free plasma protein S levels (+/- SD) were significantly lower in IBD patients (0.98+/-0.32 IU/ml) than in controls (1.06+/-0.28 IU/ml) (P < 0.05); only one patient showed protein S deficiency. 11318545 Human
protein s ibd Specific antibodies to protein S were found in four IBD patients (7.5%) and in one control (1.9%) (P = NS). 11318545 Human
protein s ibd In conclusion, free plasma protein S levels are slightly but significantly decreased in IBD patients. 11318545 Human
protein s apl Our aim was to clarify the roles in thrombosis of aPL Abs that react with complexes of phospholipids and plasma proteins such as beta(2)-glycoprotein I (beta(2)-GPI), prothrombin, protein C, protein S, and annexin V. METHODS: We determined the prevalence 11375285 Human
protein s apl The aPL Abs were measured by an ELISA system in which human plasma proteins (beta(2)-GPI, prothrombin, protein C, protein S, and annexin V) were immobilized on gamma-irradiated or plain polystyrene plates. 11375285 Human
protein s apl All participants were tested for the antiphospholipid antibody (aPL) profile, protein C, protein S, antithrombin activity, factor V Leiden mutation, and prothrombin gene G20210A mutation. 11503135 Human
protein s necrosis Heparin-induced skin necrosis in a patient with end-stage renal failure and functional protein S deficiency. 11509800 Human
protein s necrosis Warfarin-induced skin necrosis associated with Factor V Leiden and protein S deficiency. 11683790 Human
protein s necrosis In patients experiencing necrosis with a vitamin K antagonist, concomitant protein C deficiency, protein S deficiency or lupus anticoagulant has been described, whereas the precise mechanism of the other reactions is unknown. 11705306 Human
protein s apl A total of 121 patients underwent a complete screening for FVL, the PT-20210A, protein C (PC), protein S (PS), antithrombin III (ATIII), levels of factor VIII, and antiphospholipid antibodies (aPL). 11738073 Human
protein s necrosis Cutaneous necrosis revealing the coexistence of an antiphospholipid syndrome with acquired protein S deficiency, factor V Leiden and hyperhomocysteinemia. 11978573 Human
protein s inflammatory bowel disease Protein S deficiency. Description of a case associated with chronic inflammatory bowel disease. 12207201 Human
protein s inflammatory bowel disease In this short communication we describe 1 case observed by us that seems interesting for the association of a congenital and acquired form [Protein S deficiency and inflammatory bowel disease (IBD)] and for the dramatic events suffered before receiving a 12207201 Human
protein s ibd We studied disease activity in 99 IBD patients receiving anti-inflammatory therapy, in relation to: procoagulant markers, i.e. prothrombin fragment F1 + 2 (F1 + 2), D-dimer and platelet count, anticoagulant markers, i.e. protein C, protein S and antithrom 12214155 Human
protein s ibd [Predictive value of changes in the hemostasis system in patients with ischemic brain diseases] The aim of this research was to determine the importance of tracking the dynamics of changes of the hemostatic system factors (aggregation of thrombocytes, D-d 12235743 Human
protein s pilocytic astrocytoma Dural arteriovenous fistula after craniotomy for pilocytic astrocytoma in a patient with protein S deficiency. 12361657 Human
protein s gingival carcinoma This case represents the first report on the treatment of gingival carcinoma that led to the serendipitous discovery of an unrelated and unusual systemic condition, protein S deficiency. 12416779 Human
protein s necrosis The timing and evolution of the lesions and the finding of protein S deficiency were the clues for diagnosing warfarin-induced skin necrosis (WISN); the drug was discontinued and therapy with low-molecular weight heparin, plasma and prostacyclin achieved 12444385 Human
protein s malignant neoplasm In general, warfarin should be continued for at least 3 months, and longer for patients with recurrent or idiopathic venous thromboembolism, malignant neoplasm, neurologic disease with extremity paresis, obesity, or laboratory evidence of a lupus anticoag 14728051 Human
protein s metastases In patients with metastases, protein S levels were significantly elevated compared with patients without metastases and healthy control subjects: 108.0%vs 96.0% and 94.5% (P = 0.008 and P = 0.007). 12492586 Human
protein s metastases The APC-sr correlated with protein S in the control subjects and in patients without metastases but not in patients with metastases. 12492586 Human
protein s lymphoma Purified protein S was equivalent to serum in its ability to stimulate macrophage phagocytosis of apoptotic lymphoma cells, and immunodepletion of protein S eliminated the prophagocytic activity of serum. 12447359 Human
protein s ibd The lower concentrations of protein S are a significant co-factor of anticoagulant system, in the absence of other significant diseases, disorders or abnormalities which could ethiopatogenetically be significant for IBD. 12688118 Human
protein s apl To clarify the association between the various types of aPL Abs and thrombotic complications in patients with systemic lupus erythematosus(SLE), we examined the prevalence of aPL Abs to various phospholipid-binding proteins(beta 2-glycoprotein I, prothrom 12707997 Human
protein s cancer Protein C was observed on cancer cells and small blood vessels, whereas protein S was present only in the vascular bed. 12888933 Human
protein s malignancy Predisposing factors included hereditary protein C deficiency (n=3), protein S deficiency (n=2), anticardiolipin antibodies (n=1), malignancy (n=3), recent neurosurgery (n=2), infection (n=1), with multiple predisposing factors seen in three patients. 12904613 Human
protein s chronic myelomonocytic leukaemia However, the patient suffered in addition to a protein S deficiency from an antiphosphospholipid syndrome and a chronic myelomonocytic leukaemia. 12923583 Human
protein s cancer The peculiarity of the case was the unusual site of thrombosis and the lack of risk factors for DVT (only a moderated reduction of protein S without inherited thrombophilia) as well as the absence of clinical signs of cancer. 14606654 Human
protein s lung cancer Reduction of protein S has been discovered recently in patients with lung cancer but further data are required to confirm this finding. 14606654 Human
protein s non-hodgkin's lymphoma [Non-Hodgkin's lymphoma with protein S deficiency] Venous thrombosis is rare in children. 14700757 Human
protein s necrosis Warfarin skin necrosis associated with protein S deficiency and a mutation in the methylenetetrahydrofolate reductase gene. 14723717 Human
protein s cancer Patients with cancer, antiphospholipid antibodies syndrome, recurrent idiopathic event, antithrombin deficiency, protein C or protein S deficiency, homozygosity for FV Leiden, and double heterozygosity are candidates for extended long-term anticoagulation 15199464 Human
protein s cancer We excluded pregnant patients and patients with a deficiency of antithrombin, protein C, or protein S; the lupus anticoagulant; cancer; or a requirement for potentially long-term antithrombotic treatment. 15201412 Human
protein s necrosis A case of warfarin skin necrosis despite enoxaparin anticoagulation in a patient with protein S deficiency. 15253263 Human
protein s necrosis We present a patient with protein S deficiency who developed warfarin skin necrosis despite appropriate anticoagulation with enoxaparin, and review the chemical and clinical difference between UFH and LMWH. 15253263 Human
protein s hcc Mean levels of plasma protein C, protein S, antithrombin, and serum lipoprotein (a) were significantly lower in patients with HCC and in the cirrhotic group compared to the healthy controls. 15259509 Human
protein s cm In order to analyse a possible effect on haemostasis related to endothelial cell damage, protein S, TF, ET-1, PGI(2), NO, t-PA, and PAI-1 were determined for 72 hours in vitro in cell culture supernatant of HUVECs that had been exposed to 1, 10, 30, and 5 15116262 Human
protein s necrosis Skin necrosis has usually been reported in patients with congenital protein C deficiency or, less commonly, protein S deficiency. 15327563 Human
protein s cancer Patients with cancer, antiphospholipid antibodies syndrome, recurrent idiopathic event, antithrombin deficiency, protein C or protein S deficiency, homozygosity for factor V Leiden, or double heterozygosity are candidates for extended long-term anticoagul 15341706 Human
protein s essential thrombocytemia Of 4697 patients, 22 (0.47 per cent) had a stroke due to one of the following hematological pathology: polycythemia vera (4), secondary polycythemia (4), essential thrombocytemia (2), secondary thrombocytosis (4), multiple myeloma (1), CIVD (1), protein S 15602345 Human
protein s polycythemia vera Of 4697 patients, 22 (0.47 per cent) had a stroke due to one of the following hematological pathology: polycythemia vera (4), secondary polycythemia (4), essential thrombocytemia (2), secondary thrombocytosis (4), multiple myeloma (1), CIVD (1), protein S 15602345 Human
protein s multiple myeloma Of 4697 patients, 22 (0.47 per cent) had a stroke due to one of the following hematological pathology: polycythemia vera (4), secondary polycythemia (4), essential thrombocytemia (2), secondary thrombocytosis (4), multiple myeloma (1), CIVD (1), protein S 15602345 Human
protein s cancer This is the case for cancer patients, patients with the antiphospholipid syndrome, and those who belong to families with severe and symptomatic protein C, protein S, or antithrombin deficiencies. 15786931 Human
protein s cancer Pre-existing coagulopathies include antithrombin III deficiency, heparin-induced thrombocytopenia, cancer, factor XII deficiency, hemophilia, idiopathic thrombocytopenic purpura, protein S deficiency, and drug-induced platelet inhibition. 15804152 Human
protein s acute lymphoblastic leukemia This review is based on pediatric reports (- January 2004) on the presence of symptomatic thrombosis in children with hematologic malignancies, mainly acute lymphoblastic leukemia, treated with different treatment protocols and associated with acquired an 16029968 Human
protein s hematologic malignancies This review is based on pediatric reports (- January 2004) on the presence of symptomatic thrombosis in children with hematologic malignancies, mainly acute lymphoblastic leukemia, treated with different treatment protocols and associated with acquired an 16029968 Human
protein s solid tumours Protein S in cancer patients with non-metastatic solid tumours. 15993032 Human
protein s cancer Protein S in cancer patients with non-metastatic solid tumours. 15993032 Human
protein s proven metastases AIMS: To study protein S, as an acute phase protein, for its relationships with C4b-BP (C4BP), fibrinogen and Factor VIII:C in a group of patients with solid tumours, without proven metastases. 15993032 Human
protein s solid tumours AIMS: To study protein S, as an acute phase protein, for its relationships with C4b-BP (C4BP), fibrinogen and Factor VIII:C in a group of patients with solid tumours, without proven metastases. 15993032 Human
protein s adenocarcinoma METHODS: Eighty-one consecutive patients with gastrointestinal or pelvic adenocarcinoma (TNM staging: T1-3, N0-2, M0) and 58 healthy subjects were evaluated for plasma free and total protein S antigen, protein S activity, C4BP, fibrinogen and Factor VIII: 15993032 Human
protein s cancer RESULTS: When compared to the control group, the total protein S, the C4BP, the fibrinogen and the Factor VIII:C mean levels were significantly higher in the cancer group, but there was no significant difference for the free and the functional protein S m 15993032 Human
protein s cancer In both groups the free protein S was correlated with the functional and the total protein S; moreover the latter was significantly correlated with the C4BP, whereas it was significantly correlated with the fibrinogen and the Factor VIII:C only in the can 15993032 Human
protein s cancer CONCLUSIONS: Our data show that in these patients there is an acute phase response and suggest that, in the thrombophilic early cancer screening, determination of free protein S is redundant. 15993032 Human
the psa gene bph No significant differences could be found in the PSA gene expression between BPH and CA samples. 1691151 Human
the psa gene breast carcinoma Based on data of tissue culture experiments with breast carcinoma cell lines, we speculate that the PSA gene in the tumor of this patient was up-regulated by the therapeutically administered glucocorticoids after liver transplantation. 7536128 Human
the psa gene breast tumors The purpose of this study was to analyze genetic variations in the promoter region of the PSA gene, and to detect whether such variations are correlated with PSA mRNA expression in breast tumors. 11185746 Human
the psa gene breast cancer In this study, we examined the molecular mechanism underlying the expression of the PSA gene in breast cancer and breast cancer cell lines. 10188912 Human
the psa gene breast tumours To determine abnormalities associated with PSA expression in breast tumours, genomic DNA was extracted and all five exons of the PSA gene were polymerase chain reaction (PCR) amplified and sequenced on both strands. 10188912 Human
the psa gene prostate cancer Polymerase chain reaction products were sequenced to identify polymorphisms in the PSA gene promoter and to genotype the men for common single nucleotide polymorphisms (SNPs) and were cloned into luciferase reporter constructs to assay PSA promoter activi 12865450 Human
the psa gene human prostate cancer Western blot analysis, luciferase reporter assay using a variety of promoters of the PSA gene and the isolated androgen receptor response elements (ARE), as well as electrophoretic mobility shift assay (EMSA) were employed to study the effect of PC-SPES o 14532991 Human

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