IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PTCH1 Ensembl ENSG00000185920 Chromosome 9 Start 97245083 End 97319068
Description Protein patched homolog 1 (PTC1)(PTC) [Source:UniProtKB/Swiss-Prot;Acc:Q13635]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9585
     Entrez Gene : 5727
     UCSC : uc004avk.3
     GeneCards : 9585
     RefSeq : NM_000264
     CCDS : CCDS6714.1
     Uniprot : Q13635
     Interpro : Q13635
     OMIM : 601309
     GeneTests : PTCH1
     CGAP : PTCH1
     PMID : 8658145

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
5 1.45 346 5 2.40 208 0 0.00 13
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16660 AD c.1023G>C p.L341F Substitution - Missense Heterozygous 9:97282116-9728211618948947
16670 AD c.3974delT p.S1326fs*46 Deletion - Frameshift Heterozygous 9:97249385-9724938518948947
16724 AD c.3922A>G p.R1308G Substitution - Missense Heterozygous 9:97249437-9724943718948947
16814 AD c.2045G>T p.R682L Substitution - Missense Heterozygous 9:97271059-9727105918948947
17750 AD c.2062C>A p.Q688K Substitution - Missense Heterozygous 9:97271042-9727104218948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38214_at  0.53  6.40e-4  2.12e-3  0.45  5.91e-2  1.05e-1
 HG_U95  836_at  -0.24  1.81e-1  2.70e-1  0.10  7.21e-1  7.95e-1
 HG_U133A  208522_s_at  -0.28  3.26e-2  4.68e-2  0.74  2.00e-8  2.44e-8
 HG_U133A  209815_at  -0.84  2.12e-17  1.37e-16  -0.10  3.54e-1  3.64e-1
 HG_U133A  209816_at  -0.16  5.28e-2  7.31e-2  2.17  4.29e-82  1.83e-81
 HG_U133_Plus2  1555520_at  0.32  4.63e-2  7.88e-2  0.92  1.05e-8  3.96e-8
 HG_U133_Plus2  208522_s_at  0.30  6.86e-2  1.11e-1  0.62  1.29e-3  2.44e-3
 HG_U133_Plus2  209815_at  -1.18  1.65e-17  3.00e-16  -0.79  1.55e-6  4.44e-6
 HG_U133_Plus2  209816_at  -0.33  7.23e-2  1.16e-1  0.12  4.93e-1  5.53e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208522_s_at  -0.67  1.27e-1  7.93e-1  0.11  6.98e-1  1.00e+0
 HG_U133A  209815_at  0.59  1.08e-1  7.80e-1  0.02  9.40e-1  1.00e+0
 HG_U133A  209816_at  0.34  1.59e-1  8.12e-1  0.01  9.85e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38214_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 836_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208522_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209815_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209816_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1555520_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208522_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209815_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209816_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ptch xeroderma pigmentosum Mutations in the PTCH play also a major role in BCC development, being responsible for hereditary BCCs in Gorlin's syndrome, sporadic BCC, and BCCs isolated from xeroderma pigmentosum, although with a lower incidence of "UV signature". 11966727 Human
ptc odontogenic tumors BACKGROUND: To clarify the roles of Sonic hedgehog (SHH) signal transduction in oncogenesis and cytodifferentiation of odontogenic tumors, expression of SHH, Patched (PTC), Smoothened (SMO), and GLI1 was analyzed in ameloblastomas as well as in tooth germ 15128061 Human
ptc malignant ameloblastoma METHODS: Tissue specimens of 9 tooth germs, 36 benign ameloblastomas, and 1 malignant ameloblastoma were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry for the expression of SHH, PTC, SMO, and GLI1. 15128061 Human
ptc ameloblastoma RESULTS: Expression of SHH, PTC, SMO, and GLI1 mRNA was detected in all tooth germ and ameloblastoma samples. 15128061 Human
ptc odontogenic tumors CONCLUSION: Expression of SHH, PTC, SMO, and GLI1 in tooth germs and ameloblastomas suggests that these SHH signaling molecules might play a role in epithelial-mesenchymal interactions and cell proliferation in tooth development as well as in growth of th 15128061 Human
ptch non-melanoma skin cancer We initially tested whether loss of heterozygosity (LOH) at the p53 and the patched (ptch) genes was related to EMAST in a series of 61 non-melanoma skin cancer (NMSC) tumors. 12118368 Human
ptc cancer Despite extensive genetic studies demonstrating the importance of these receptor components in embryonic patterning and cancer, the mechanism by which Ptc regulates Smo is not understood. 12192414 Mouse
nbccs fibroma Tumors in patients with NBCCS include basal cell carcinoma, medulloblastoma, fibroma and rhabdomyosarcoma (RMS). 12204003 Human
ptc neuroectodermal tumors Ptc is a tumor suppressor gene whereas Smo serves as a proto-oncogene of neuroectodermal tumors. 12241103 Human
ptc astrocytic tumors We have analyzed mRNA expression of Ptc, Smo, and Gli family members in human astrocytic tumors. 12241103 Human
ptc astrocytic tumors In summary, our results indicate that Ptc and Smo mRNA levels have an inverse correlation with histological malignancy and suggest that these gene products are implicated in the suppression of astrocytic tumors. 12241103 Human
ptch nevus sebaceous of jadassohn We believe that SP may be a transitional step from nevus sebaceous to basal cell carcinoma, since molecular studies show PTCH gene in all three lesions, the origins of SP are still debatable, and both SP and BCC can arise in nevus sebaceous of Jadassohn. 12661924 Human
ptch familial breast cancer Coincident PTCH and BRCA1 germline mutations in a patient with nevoid basal cell carcinoma syndrome and familial breast cancer. 11231326 Human
ptc ovarian carcinomas PTC mutations have been observed in sporadic tumors including basal cell and ovarian carcinomas and medulloblastoma. 11277394 Human
ptch squamous cell carcinoma of the skin PTCH mutations in squamous cell carcinoma of the skin. 11286632 Human
ptc bladder cancer Our data support the hypothesis of Ptc acting as a tumor suppressor gene in bladder cancer. 15026327 Mouse
ptch craniopharyngioma Our data indicate that a subset of craniopharyngiomas are monoclonal and the mutations in the PTCH, Gsalpha, and Gi2alpha contribute little if any to craniopharyngioma development. 11524144 Human
the patched gene secondary tumors To substantiate further a role of the patched-hedgehog signaling pathway in secondary tumors arising within nevus sebaceous, we examined 11 nevus sebaceous associated with secondary tumors for loss of heterozygosity of the patched gene region by microsate 11886539 Human
ptc malignant brain tumor Recently, a subset of medulloblastoma, the most common malignant brain tumor in children, was found to contain somatic mutations in the human ptc gene. 10786690 Human
ptch juvenile polyposis CONCLUSIONS: Mutations in PTEN and PTCH are unlikely to cause juvenile polyposis in the absence of clinical features indicative of CS, BRRS, or GS. 10764709 Human
ptch xeroderma pigmentosum (xp) Patched exhibits tumor suppression function and has been shown to be mutated in skin cancers isolated from DNA repair-proficient patients or from xeroderma pigmentosum (XP), a DNA repair-deficient syndrome.We have reviewed and analyzed in detail the diffe 10838143 Human
ptch dermoid cysts More generally, if our similar observations of incomplete heterozygosity in this region for dermoid cysts can be interpreted as loss of heterozygosity, PTCH alterations may prove to be a necessary, and perhaps the initiating event, in formation and growth 10868476 Human
ptch rhabdomyosarcoma Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the proto-oncogene Smoothened (SMO) or that inactivate the tumour suppressor Patched (PTCH). 10984056 Human
ptch non-melanoma skin cancer Signature mutations are present in TP53 and PTCH, two tumor suppressor genes responsible for non-melanoma skin cancer. 10537000 Human
ptch colon cancer We have investigated frameshift mutations in exonic repeats in the ATR, BRCA1, BRCA2, PTCH, CTCF, Cx26, NuMa and TGFbetaRII genes, using human tumor samples from stomach, esophagus, breast and skin and melanoma, as well as colon cancer and endometrial can 10545425 Human
ptch endometrial cancer We have investigated frameshift mutations in exonic repeats in the ATR, BRCA1, BRCA2, PTCH, CTCF, Cx26, NuMa and TGFbetaRII genes, using human tumor samples from stomach, esophagus, breast and skin and melanoma, as well as colon cancer and endometrial can 10545425 Human
ptch melanoma We have investigated frameshift mutations in exonic repeats in the ATR, BRCA1, BRCA2, PTCH, CTCF, Cx26, NuMa and TGFbetaRII genes, using human tumor samples from stomach, esophagus, breast and skin and melanoma, as well as colon cancer and endometrial can 10545425 Human
ptch gastrointestinal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch hereditary nonpolyposis colorectal cancer Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch gastrointestinal neoplasms Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch gastric cancer Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch colonic polyps Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch neurofibromatosis Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch gastrointestinal cancer Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch juvenile polyposis Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch colorectal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptc renal carcinoma Ptc protein presents a sterol sensing domain which has been identified in several proteins, including TRC8, recently implicated in hereditary renal carcinoma and which is also expressed as a 2.5-kb transcript in several rat brain areas. 11755778 Human
ptc seborrheic keratosis In addition, no obvious signals for ptc and smo mRNA were detected in the normal human epidermis, appendages, or seborrheic keratosis, indicating that the abnormal proliferation of follicular epithelial cells caused by ptc, smo and/or other genetic change 10504535 Human
ptc soft-tissue sarcoma Here we report that mice heterozygous for ptc develop many of the features characteristic of Gorlin syndrome and that they exhibit a high incidence of rhabdomyosarcomas (RMS), the most common soft-tissue sarcoma in children. 9585239 Mouse
ptc gastric cancer Ptc was markedly reduced in atrophy and only weakly positive in intestinal metaplasia and gastric cancer. 14691301 Human
ptc metaplasia Ptc was markedly reduced in atrophy and only weakly positive in intestinal metaplasia and gastric cancer. 14691301 Human
ptch transitional cell carcinoma PTCH gene mutations in invasive transitional cell carcinoma of the bladder. 9764827 Human
ptc inherited cancer syndromes Frequent allelic losses on chromosome 9 are seen in a wide variety of human tumors; moreover, two genes (P16 and PTC) whose mutant alleles confer predispositions to some inherited cancer syndromes have been identified on this chromosome. 9818027 Human
ptch malignant brain tumors To determine the involvement of PTCH in sporadic MBs, which represent the most frequent malignant brain tumors in children, we screened for PTCH alterations in an unselected panel of 64 biopsy samples from 62 patients and four continuous MB cell lines, al 9187099 Human
ptch meningiomas In addition, we identified missense mutations in PTCH in two of seven breast carcinomas, one of nine meningiomas, and one colon cancer cell line. 9192811 Human
ptch colon cancer In addition, we identified missense mutations in PTCH in two of seven breast carcinomas, one of nine meningiomas, and one colon cancer cell line. 9192811 Human
ptch breast carcinomas In addition, we identified missense mutations in PTCH in two of seven breast carcinomas, one of nine meningiomas, and one colon cancer cell line. 9192811 Human
ptch colon carcinomas No PTCH gene mutations were detected in 10 primary colon carcinomas and eighteen bladder carcinomas. 9192811 Human
ptch bladder carcinomas No PTCH gene mutations were detected in 10 primary colon carcinomas and eighteen bladder carcinomas. 9192811 Human
nbccs primitive neuroectodermal tumours Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS patients and a subset of PNETs was previously found with allelic imbalance at 9q22-q23, the region containing the gene for NBCCS (PTCH). 9233770 Human
ptch primitive neuroectodermal tumours Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS patients and a subset of PNETs was previously found with allelic imbalance at 9q22-q23, the region containing the gene for NBCCS (PTCH). 9233770 Human
nbccs keratocyst These results implicate homozygous inactivation of the NBCCS gene in the initiation and progression of the odontogenic keratocyst. 8762878 Human
ptc bladder cancer Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. 8895761 Human
ptc bladder cancer Because the nevoid basal cell carcinoma syndrome gene has long been speculated to be a putative tumor suppressor gene in bladder cancer and this gene has recently been characterized as the human homologue of the Drosophila patched gene (PTC), 20 primary b 8895761 Human
ptc bladder cancer GAS1 and PTC do not seem to be frequently mutated in bladder cancer. 8895761 Human
ptch meningioma A new germline mutation of the PTCH gene in a Japanese patient with nevoid basal cell carcinoma syndrome associated with meningioma. 12604725 Human
ptch meningioma We employed polymerase chain reaction and DNA sequencing analysis to characterize the PTCH gene in a Japanese nevoid basal cell carcinoma syndrome (NBCCS) patient suffering from meningioma, multiple basal cell carcinoma and epidermal cysts. 12604725 Human
ptch epidermal cysts We employed polymerase chain reaction and DNA sequencing analysis to characterize the PTCH gene in a Japanese nevoid basal cell carcinoma syndrome (NBCCS) patient suffering from meningioma, multiple basal cell carcinoma and epidermal cysts. 12604725 Human
ptch epithelial neoplasms Basaloid follicular hamartoma may represent an indolent lesion within the spectrum of basaloid epithelial neoplasms associated with deregulation of the PTCH signaling pathway. 12652194 Human
ptch non-melanoma skin cancer Although our results do not exclude the presence of clonal alterations of the PTCH gene in skin cancers or mutations in other exons that were not screened, the present data do not support the presence of frequent mutations reported for non-melanoma skin c 12700822 Human
nbccs cancer predisposition syndrome NBCCS is a rare autosomal dominant cancer predisposition syndrome, which is important to recognize when a patient has multiple odontogenic keratocysts, because lifelong monitoring is essential for patient management. 15316550 Human
ptc bladder tumors Because the nevoid basal cell carcinoma syndrome gene has long been speculated to be a putative tumor suppressor gene in bladder cancer and this gene has recently been characterized as the human homologue of the Drosophila patched gene (PTC), 20 primary b 8895761 Human
ptc basal cell nevus syndrome Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. 9115210 Human
ptc squamous cell carcinomas of the lung To investigate the possible role of the PTC gene on chromosome 9q22.3, that was identified as the cause of nevoid basal cell carcinoma syndrome, during carcinogenesis in esophagus and lung, we examined 20 esophageal squamous cell carcinomas and 10 squamou 9140104 Human
ptc basal cell nevus syndrome The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS). 9262482 Human
ptc brain tumors However, ptc+/- mice survive and develop spontaneous cerebellar brain tumors, suggesting that ptc may function as a tumor suppressor gene. 10786690 Mouse
ptc medulloblastoma Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that trigger ligand-independent activity of the Hedgehog (Hh) signalling pathway are associated with human tumours such as basal cell carcinoma (BCC) and medulloblastoma. 12192414 Human
ptc brain tumor The current report demonstrates the feasibility of longitudinal high-resolution MRI in two mouse brain tumor models: patched heterozygous (ptc +/-) mice with spontaneously arising posterior fossa tumors that resemble human medulloblastoma, and homozygous 12777077 Mouse
ptc brain tumors Whereas alteration of Ptc function is associated with developmental abnormalities and brain tumors, its functional activity and roles in the adult brain have yet to be elucidated. 16045492 Human
ptc1 pediatric neoplasms Other genetic constructs in mice involving the genes p53, ptc1, and Nf1 have produced tumors remarkably similar to some of the human pediatric neoplasms. 15313589 Mouse
ptc1 synovial chondromatosis Because dysregulation of hedgehog signalling is a feature of several benign cartilaginous tumours, expression of the hedgehog target genes PTC1 and GLI1 was examined in this study in samples from human synovial chondromatosis. 15834844 Human
ptc1 benign cartilaginous tumours Because dysregulation of hedgehog signalling is a feature of several benign cartilaginous tumours, expression of the hedgehog target genes PTC1 and GLI1 was examined in this study in samples from human synovial chondromatosis. 15834844 Human
ptch primitive neuroectodermal tumors Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. 9205058 Human
ptch desmoplastic medulloblastomas PTCH mutations were found in 3 BCCs (33.3%) and in 5 PNETs (14%), including 1 of 5 cerebral PNETs, 2 of 15 medulloblastomas, and 2 of 17 desmoplastic medulloblastomas. 9205058 Human
ptch nevus Insight into their genesis came from identification of mutations in the PATCHED gene (PTCH) in patients with the basal-cell nevus syndrome, a hereditary disease characterized by multiple BCCs and by developmental abnormalities. 9422511 Human
ptch nevus According to this model, the inhibition of SMO signalling is relieved following mutational inactivation of PTCH in basal-cell nevus syndrome. 9422511 Human
ptch brain tumors In the present study, this protocol was employed to analyze the expression of the PTCH, Fas-receptor, NF-1, beta2-microglobulin and GAPD genes in human brain tumors. 9458162 Human
ptch pnet PTCH mutations were detected in eight BCCs and one PNET. 9581815 Human
ptch transitional cell carcinoma of the bladder PTCH gene mutations in invasive transitional cell carcinoma of the bladder. 9764827 Human
ptch pnet Thus, PTCH is the only gene in this complex pathway that is mutated with notable frequency in PNET. 10564585 Human
ptch brain tumor Medulloblastoma, a brain tumor, develops in about 3% of NBCCS patients, and mutations in PTCH have also been described in a subset of sporadic medulloblastomas. 10738305 Human
ptch cerebellar tumors For clearer definition of the role of PTCH as a tumor suppressor in medulloblastoma, 13 cerebellar tumors from transgenic Ptch(+/-) mice were examined for alterations in the remaining Ptch allele. 10738305 Mouse
ptch medulloblastoma Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the proto-oncogene Smoothened (SMO) or that inactivate the tumour suppressor Patched (PTCH). 10984056 Human
ptch bowen's disease We found a high level of PTCH expression in all 12 BCCs, while 23 of the other tumours and four specimens of normal skin showed no or weak expression of the gene, with the exception of one specimen from a patient with Bowen's disease which had high e 10233224 Human
ptch breast tumours In addition, a subset of 45 primary breast tumours was analysed for mutations in the PTCH coding region and 48 samples in previously implicated exons of human smoothened, but no mutations were found. 10505029 Human
ptch gastrointestinal stromal tumors Topics discussed here include PTEN mutations and colonic polyps; WNT signaling, APC, beta-catenin, and gastrointestinal neoplasms; mismatch-repair genes (MLH1, MSH2, PMS1, MSH6) and hereditary nonpolyposis colorectal cancer; MYH mutations and autosomal re 14518068 Human
ptch sebaceous tumors We now show that PTCH is up-regulated in both human and mouse sebaceous tumors and is accompanied by overexpression of Indian hedgehog (IHH). 12917489 Human
ptch common tumor The genes analyzed included 10 common tumor suppressor genes, as well as the PTCH gene, which is mutated in nevoid basal cell carcinoma syndrome. 14987156 Human
ptch medulloblastomas We also demonstrate linked overexpression of BMI1 and patched (PTCH), suggestive of SHH pathway activation, in a substantial fraction of primary human medulloblastomas. 15029199 Human
ptch hyperplastic polyp In this study, normal colon and colonic lesions (hyperplastic polyp, adenoma, and colonic adenocarcinoma) were examined by immunohistochemistry using antibodies against Hh signalling molecules: the secreted protein Sonic hedgehog (SHH), its receptor Patch 15258993 Human
ptch colonic adenocarcinoma In this study, normal colon and colonic lesions (hyperplastic polyp, adenoma, and colonic adenocarcinoma) were examined by immunohistochemistry using antibodies against Hh signalling molecules: the secreted protein Sonic hedgehog (SHH), its receptor Patch 15258993 Human
ptch adenocarcinomas of the colon Expression of SHH, PTCH, and SMOH was up-regulated in hyperplastic polyps, adenomas, and adenocarcinomas of the colon, and SHH expression correlated with increased expression of the proliferation marker Ki-67 in all lesions examined. 15258993 Human
ptch hyperplastic polyps Expression of SHH, PTCH, and SMOH was up-regulated in hyperplastic polyps, adenomas, and adenocarcinomas of the colon, and SHH expression correlated with increased expression of the proliferation marker Ki-67 in all lesions examined. 15258993 Human
ptch nonmelanoma skin cancer PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. 15888139 Human
ptch nonmelanoma skin cancers Objectives Accordingly, the status of PTCH codon 1315 was analysed for a possible association with the development of nonmelanoma skin cancers (NMSCs) in a pilot study. 15888139 Human
ptch ovarian fibroma Role of the hedgehog/patched signaling pathway in oncogenesis: a new polymorphism in the PTCH gene in ovarian fibroma. 15659790 Human
ptch ovarian fibroma Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibroma and dermoids. 15659790 Human
ptch stromal tumors Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors? 16084949 Human
ptch ovarian fibromas Some ovarian fibromas and rare fibrosarcomas are associated with Gorlin syndrome, which is caused by mutation in the human homologue of Drosophila patched gene (PTCH), localized on chromosome 9q22.3. 16084949 Human
ptch ovarian tumors in the thecoma-fibroma group The relationship between PTCH gene and sporadic ovarian tumors in the thecoma-fibroma group has not been well characterized. 16084949 Human
ptch cellular fibromas LOH at 9q22.3 was detected in 4 (67%) of 6 cellular fibromas, with the highest frequency at microsatellite marker D9S15, which localizes proximal to the PTCH gene. 16084949 Human
ptch cellular fibromas The results indicate that (1) LOH at both PTCH gene and STK11 gene is relatively frequent in cellular fibromas; (2) approximately a quarter of luteinized thecomas exhibited LOH of the PTCH gene; in both neoplasms, cellular fibromas and luteinized thecomas 16084949 Human
ptch luteinized thecomas The results indicate that (1) LOH at both PTCH gene and STK11 gene is relatively frequent in cellular fibromas; (2) approximately a quarter of luteinized thecomas exhibited LOH of the PTCH gene; in both neoplasms, cellular fibromas and luteinized thecomas 16084949 Human
the ptc gene squamous cell carcinomas of the lung To investigate the possible role of the PTC gene on chromosome 9q22.3, that was identified as the cause of nevoid basal cell carcinoma syndrome, during carcinogenesis in esophagus and lung, we examined 20 esophageal squamous cell carcinomas and 10 squamou 9140104 Human
the ptc gene bladder tumours Our results suggest that the PTC gene is a putative suppressor at the 9q22 locus and that haploinsufficiency of this gene may be an early event in the development of papillary bladder tumours. 12771948 Human
ptch1 ductal carcinoma in situ (dcis) In human clinical samples, altered hedgehog signaling occurs early in breast cancer development, with PTCH1 expression reduced in approximately 50% of ductal carcinoma in situ (DCIS) and invasive breast cancers (IBC). 17287253 Human
ptch1 invasive breast cancers (ibc) In human clinical samples, altered hedgehog signaling occurs early in breast cancer development, with PTCH1 expression reduced in approximately 50% of ductal carcinoma in situ (DCIS) and invasive breast cancers (IBC). 17287253 Human
the patched gene nevus Insight into their genesis came from identification of mutations in the PATCHED gene (PTCH) in patients with the basal-cell nevus syndrome, a hereditary disease characterized by multiple BCCs and by developmental abnormalities. 9422511 Human
ptch primitive neuroectodermal tumours (pnets) Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS patients and a subset of PNETs was previously found with allelic imbalance at 9q22-q23, the region containing the gene for NBCCS (PTCH). 9233770 Human
ptch primitive neuroectodermal tumors (pnets) About one-third of sporadic basal cell carcinomas (BCCs) of the skin and 10-15% of primitive neuroectodermal tumors (PNETs) of the central nervous system show mutations in the PTCH tumor suppressor gene. 9581815 Human
ptch xeroderma pigmentosum (xp) Molecular analysis of p53 and patched (PTCH), two candidate tumor suppressor genes for non-melanocytic skin cancer, was performed in skin tumors from six patients affected by the cancer-prone disease xeroderma pigmentosum (XP). 10656695 Human
ptch xeroderma pigmentosum (xp) Thus far only the point mutations in the P53 gene from squamous cell carcinomas and BCCs, and in PTCH gene from BCC of xeroderma pigmentosum (XP) patients appear to be unambiguously attributable to solar UV radiation. 11684448 Human
ptch ovarian fibromas Occasionally, patients with NBCCS develop other neoplasms, particularly medulloblastomas and ovarian fibromas, indicating that the PTCH gene is a tumor-suppressor gene. 15688838 Human
the patched gene xeroderma pigmentosum (xp) Mutations in the receptor of SHH, the patched gene, have been characterized in sporadic BCCs as well as those from patients with the rare genetic syndromes nevoid BCC and xeroderma pigmentosum (XP). 12499255 Human
patched basal cell nevus syndrome Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. 9115210 Human
patched basal cell nevus syndrome The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS). 9262482 Human
patched superficial bladder cancer Alteration of the PATCHED locus in superficial bladder cancer. 12771948 Human
patched superficial bladder cancer [The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer] Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. 14613000 Human
patched superficial bladder cancer We propose PATCHED as a TSG candidate in superficial bladder cancer. 14613000 Human
patched xeroderma pigmentosum (xp) We present data showing unique SHH mutations in BCCs from repair-deficient, skin cancer-prone xeroderma pigmentosum (XP) patients, which are characterized by high levels of UV-specific mutations in key genes involved in skin carcinogenesis, including PATC 15150112 Human
patched xeroderma pigmentosum Analysis of sporadic basal cell carcinomas and those from repair deficient xeroderma pigmentosum patients has revealed mutational inactivation of PATCHED and gain of function mutations of the proto-oncogenes, SMOOTHENED and SONIC HEDGEHOG associated with 15978322 Human
ptc lung cancer [Effect of hereditary factors on tolerance for surgical treatment in patients with lung cancer] Genetic polymorphism at 10 independent loci (ABO, RH, HP, GC, PI, TF, ACP1, PGM1, GLO1, and PTC) was studied in male patients with lung squamous cell carcinoma 8755041 Human
ptc lung cancer [Role pf genetic and other biomarkers in the prognostication of postoperative course in patients with lung cancer] Relationships between genetic polymorphisms (ABO, RH, HP, TF, GC, Pi, ACP1, PGM1, GLO1, PTC) and some clinical, biochemical, and functional 9102077 Human
ptc bladder tumours Our results suggest that the PTC gene is a putative suppressor at the 9q22 locus and that haploinsufficiency of this gene may be an early event in the development of papillary bladder tumours. 12771948 Human
ptch1 common tumours Mutations in the human homologue of Drosophila Patched1 (PTCH1) have been found in several common tumours including basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma (RMS). 12845631 Human
ptch1 common tumor Mutations in PTCH1 lead to constitutive expression of HH target genes and a relationship between mutated PTCH1 and the most common tumor form in the Western world, Basal Cell Carcinoma (BCC) has been clearly established. 15087129 Human
ptch1 prostate tumors We find that high levels of hedgehog target genes, PTCH1 and hedgehog-interacting protein (HIP), are detected in over 70% of prostate tumors with Gleason scores 8-10, but in only 22% of tumors with Gleason scores 3-6. 15482598 Human
ptch1 metastatic tumors Furthermore, four available metastatic tumors all have high expression of PTCH1 and HIP. 15482598 Human
ptch1 cystic lesions Recently, we investigated the status of the PTCH1 locus in a large set of sporadic non-inflammatory, developmental cystic lesions. 15492847 Human
ptch1 ovarian dermoid cysts Our data showed allelic loss of microsatellite markers in close vicinity to the PTCH1 locus in both odontogenic keratocysts and dentigerous cysts as well as in ovarian dermoid cysts (ODC). 15492847 Human
ptch1 transitional cell carcinoma (tcc) The PTCH1 gene at 9q22 is also considered as a candidate tumor suppressor in transitional cell carcinoma (TCC), of which >50% show LOH in this region. 15521068 Human
ptch1 medulloblastoma We conclude that clinically recognizable syndromes are uncommon among patients with medulloblastoma, however, PTCH1 and SUFU mutations are present at a low but significant frequency. 15759260 Human
ptch1 primary gastric cancers Here, we report our findings that the elevated expression of hedgehog target genes human patched gene 1 (PTCH1) or Gli1 occurs in 63 of the 99 primary gastric cancers. 15905200 Human
ptch1 gastric cancer Treatment of gastric cancer cells with KAAD-cyclopamine, a hedgehog signaling inhibitor, decreases expression of Gli1 and PTCH1, resulting in cell growth inhibition and apoptosis. 15905200 Human
ptch1 ameloblastoma Polymorphisms in PTCH1 affect the risk of ameloblastoma. 16109989 Human
ptch1 ameloblastoma Both CTNNB1 and PTCH1 are important in tooth development and are expressed in ameloblastoma. 16109989 Human
ptch1 ameloblastoma The aim of this study was to investigate whether genetic alterations of CTNNB1 and PTCH1 are present in ameloblastoma. 16109989 Human
ptch1 ameloblastoma The results of this study indicate a possible relationship between the CGG8 allele in PTCH1 and the risk for ameloblastoma. 16109989 Human
nbccs primitive neuroectodermal tumours (pnets) Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS patients and a subset of PNETs was previously found with allelic imbalance at 9q22-q23, the region containing the gene for NBCCS (PTCH). 9233770 Human
ptch medulloblastomas The human Patched (PTCH) gene is a classical tumour suppressor gene for basal cell carcinomas and medulloblastomas, the loss of which causes increased signalling through the Sonic Hedgehog (SHH) pathway. 17230190 Human
ptch desmoplastic medulloblastoma Case report. The authors present the case of a 2.5-year-old African-American boy with desmoplastic medulloblastoma (MB) and nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, an autosomal dominant disorder resulting from mutation 17328283 Human
ptch endometrial carcinoma EXPERIMENTAL DESIGN: The expression of sonic hedgehog (Shh), patched (Ptch), Smoothened (Smo), and Gli1 was examined in various endometrial tissues and endometrial carcinoma cell lines. 17332280 Human
ptch endometrial hyperplasia RESULTS: The expression of Shh, Ptch, Smo, and Gli1 was very weak in normal endometrium, but was increased in endometrial hyperplasia and carcinoma stepwisely with significant differences. 17332280 Human
ptch endometrial carcinoma No somatic mutations for ptch and smo genes were detected in the endometrial carcinoma cases examined. 17332280 Human
the patched gene squamous carcinomas Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. 17230190 Mouse
ptch human skin cancers Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. 10545995 Human
ptch basaloid follicular hamartoma Basaloid follicular hamartoma may represent an indolent lesion within the spectrum of basaloid epithelial neoplasms associated with deregulation of the PTCH signaling pathway. 12652194 Human
ptc lung squamous cell carcinoma [Effect of hereditary factors on tolerance for surgical treatment in patients with lung cancer] Genetic polymorphism at 10 independent loci (ABO, RH, HP, GC, PI, TF, ACP1, PGM1, GLO1, and PTC) was studied in male patients with lung squamous cell carcinoma 8755041 Human
ptc superficial papillary bladder tumors Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. 15026327 Human
ptch1 jaw cysts Odontogenic keratocysts in humans are aggressive, noninflammatory jaw cysts that may harbor PTCH1 mutations, leading to constitutive activity of the embryonic Hedgehog (Hh) signaling pathway. 16936257 Human
nbccs xeroderma pigmentosum group a Two recessive cancer-predisposition syndromes, xeroderma pigmentosum group A (XPAC) and Fanconi anemia group C (FACC), map to the NBCCS region; and unusual, dominant mutations in these genes have been proposed as the cause of Gorlin syndrome. 8755929 Human
ptch epithelial neoplasms The dysregulation in cellular proliferation and signaling induced by decreased NF1 along with the PTCH gene mutation may explain the pattern of immunohistochemical staining within these tumors, and the rare association of NF1 with epithelial neoplasms. 16207184 Human
ptch rhabdomyoma Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. 16294371 Human
ptch fetal rhabdomyoma This study aimed to analyse PTCH status in an NBCCS patient with fetal rhabdomyoma and to investigate whether deregulation of hedgehog signalling, as shown by altered expression of hedgehog pathway components and/or genetic imbalances, is a general findin 16294371 Human
ptch fetal rhabdomyoma The NBCCS patient had a novel PTCH germ-line mutation, 1370insT, and developed a fetal rhabdomyoma that harboured a 30 bp in-frame deletion in the second allele resulting in homozygous inactivation of PTCH. 16294371 Human
ptch embryonal rhabdomyosarcomas Immunohistochemical staining revealed a subgroup of fetal rhabdomyomas and embryonal rhabdomyosarcomas (12/34) lacking PTCH immunoreactivity. 16294371 Human
ptch embryonal rhabdomyosarcoma Four of nine informative fetal rhabdomyomas and embryonal rhabdomyosarcomas showed loss of heterozygosity (LOH) in the PTCH region with two of these (one fetal rhabdomyoma and one embryonal rhabdomyosarcoma) also showing LOH in the SUFU region. 16294371 Human
ptch embryonal rhabdomyosarcomas Four of nine informative fetal rhabdomyomas and embryonal rhabdomyosarcomas showed loss of heterozygosity (LOH) in the PTCH region with two of these (one fetal rhabdomyoma and one embryonal rhabdomyosarcoma) also showing LOH in the SUFU region. 16294371 Human
ptch fetal rhabdomyoma Four of nine informative fetal rhabdomyomas and embryonal rhabdomyosarcomas showed loss of heterozygosity (LOH) in the PTCH region with two of these (one fetal rhabdomyoma and one embryonal rhabdomyosarcoma) also showing LOH in the SUFU region. 16294371 Human
ptch esophageal squamous cell carcinoma PTCH gene expression as a potential marker for esophageal squamous cell carcinoma. 16475698 Human
ptch esophageal squamous cell carcinoma BACKGROUND: The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined. 16475698 Human
ptch esophageal scc MATERIALS AND METHODS: To test whether PTCH can serve as a candidate marker for esophageal SCC, a quantitative reverse transcription (RT) -PCR for the PTCH gene was performed and the possible relationship between PTCH gene expression levels and clinicopat 16475698 Human
ptch esophageal scc RESULTS: A low PTCH expression score was observed in 18 out of 29 (62%) esophageal SCCs and it was significantly correlated with a poor prognosis in esophageal SCC patients (p = 0.0073). 16475698 Human
ptch esophageal scc CONCLUSION: These results suggest that PTCH might serve as a new parameter for the prediction of prognosis in esophageal SCC. 16475698 Human
ptch craniopharyngioma The analyzed tumors of the family show extensive loss of heterozygosity in the PTCH region, both basocellular and in particular craniopharyngioma, and in the latter a high expression of beta-catenin was detected. 16596257 Human
ptch chondrosarcomas We describe a gradual decrease in the expression of Patched (PTCH) and glioma-associated oncogene homologue 1 (GLI1) (both transcribed upon IHH activity), and GLI2 with increasing malignancy, suggesting that IHH signalling is inactive and PTHLH signalling 16755518 Human
ptch cervical intraepithelial neoplasia (cin) A total of 106 uterine cervical cancers and related lesions (37 squamous cell carcinomas, 23 cervical intraepithelial neoplasia (CIN) III, 10 CIN II, four CIN I, 32 normal cervical epithelia) were immunohistochemically analyzed with anti-Shh, Indian Hh (I 16778829 Human
ptch cin A total of 106 uterine cervical cancers and related lesions (37 squamous cell carcinomas, 23 cervical intraepithelial neoplasia (CIN) III, 10 CIN II, four CIN I, 32 normal cervical epithelia) were immunohistochemically analyzed with anti-Shh, Indian Hh (I 16778829 Human
ptch cin ii A total of 106 uterine cervical cancers and related lesions (37 squamous cell carcinomas, 23 cervical intraepithelial neoplasia (CIN) III, 10 CIN II, four CIN I, 32 normal cervical epithelia) were immunohistochemically analyzed with anti-Shh, Indian Hh (I 16778829 Human
ptch uterine cervical cancers A total of 106 uterine cervical cancers and related lesions (37 squamous cell carcinomas, 23 cervical intraepithelial neoplasia (CIN) III, 10 CIN II, four CIN I, 32 normal cervical epithelia) were immunohistochemically analyzed with anti-Shh, Indian Hh (I 16778829 Human
ptch human pancreatic cancer CONCLUSIONS: Because aberrant expressions of PTCH and Smo were common in human pancreatic carcinoma tissues and were associated with the low-level differentiation of tumor tissue and hyperglycemia, this indicated that these molecules played a fundamental 16804411 Human
ptch human pancreatic carcinoma CONCLUSIONS: Because aberrant expressions of PTCH and Smo were common in human pancreatic carcinoma tissues and were associated with the low-level differentiation of tumor tissue and hyperglycemia, this indicated that these molecules played a fundamental 16804411 Human
bcns radiation-induced meningiomas This is the first report in the dermatologic literature, to our knowledge, of radiation-induced meningiomas in a patient with BCNS. 16227103 Human
ptc odontogenic tumors The objective of this paper is to investigate the protein distribution of SHH and its receptor PTC, SMO and transcription factor GLI1 in various odontogenic tumors. 16376138 Human
ptc odontogenic tumor Odontogenic tumor tissues including 34 epithelial derived, 24 epithelial-mesenchymal derived, and 26 mesenchymal derived were examined by immunohistochemistry for SHH, PTC, SMO and GLI1. 16376138 Human
ptc odontogenic tumors Immunoreactivity for SHH, PTC, SMO and GLI1 was detected in both epithelial derived odontogenic tumors and epithelial-mesenchymal derived odontogenic tumors with or without dental hard tissue formation. 16376138 Human
ptc odontogenic tumors The findings suggest SHH, PTC, SMO and GLI1 protein are predominantly located in epithelial components in various odontogenic tumors and might participate in the proliferation of epithelial components of odontogenic tumors. 16376138 Human
ptch1 gastric cancer SHH up-regulation, IHH upregulation and HHIP down-regulation lead to aberrant activation of Hedgehog signaling through PTCH1 to GLI1 in gastric cancer. 16258256 Human
ptch1 chondrosarcomas We found that chondrosarcomas expressed high levels of the Hedgehog target genes PTCH1 and GLI1. 16400033 Human
ptch1 skin tumor By combining conditional knockout technology with the inducible activity of the Keratin6 promoter, we provide in vivo evidence that loss of Ptch1 function from the basal cell population of mouse skin is sufficient to induce rapid skin tumor formation, rem 16489008 Mouse
ptch1 bcc In addition, similar to BCC tumors, all cell lines had lost the wildtype Ptch1 allele, expressed BCC molecular markers, and responded similarly to cyclopamine, a small molecule inhibitor of Hedgehog signaling. 16881970 Mouse
ptch1 tumors In addition, similar to BCC tumors, all cell lines had lost the wildtype Ptch1 allele, expressed BCC molecular markers, and responded similarly to cyclopamine, a small molecule inhibitor of Hedgehog signaling. 16881970 Mouse
ptc1 pituitary adenomas Methods: Using immunohistochemistry, we determined the expression of Shh and its receptors Patched 1 (Ptc1) and Patched 2 (Ptc2) in 55 human pituitary adenomas compared with the normal pituitary gland. 16159933 Human
ptc1 pituitary adenomas Results: Ptc1 and Ptc2 were present, whereas Shh was down-regulated in pituitary adenomas and completely absent in Cushing tumors. 16159933 Human
ptch pancreatic pseudocyst The PTCH and Smo expression in 39 resected pancreas specimens from 28 patients with pancreatic cancer, 6 with chronic pancreatitis (as control), and 5 with pancreatic pseudocyst (as control) were detected by reverse transcriptase polymerase chain reaction 16804411 Human
ptch tcc We first examined the steady state mRNA transcription of the PTCH, SMOH and GLI3 genes of the HH signal transduction pathway in TCC cell lines and normal urothelium. 9764827 Human
ptch tcc Normal urothelium and TCC cell lines express these three genes within the PTCH signal transduction pathway. 9764827 Human
ptch tcc We then screened for PTCH mutations in 'hot spot' exons 6, 8, 13 and 16 by PCR/SSCP analysis of genomic DNAs from 54 TCC tumor samples and control autologous peripheral blood lymphocytes. 9764827 Human
ptch tcc Both TCC tumors that contained PTCH mutations had a loss of heterozygosity at 9q. 9764827 Human
ptch tcc Although the PTCH protein has an unknown function in urothelial cells, the detection of the PTCH, SMOH and GLI3 transcripts in normal urothelium and TCC cell lines and rare PTCH mutations in tumor samples suggest that the HH pathway may have a role in con 9764827 Human
nbccs central nervous system tumor Another NBCCS-associated cancer is medulloblastoma, a common central nervous system tumor in children. 9041183 Human
ptch solid tumors BACKGROUND: While for most human solid tumors genetic alterations of few distinct genetic regions have been found, studies on basal cell carcinomas (BCC) have shown the prevalence of several abnormalities including alterations of the three ras genes, GAP 11752813 Human
ptch carcinomas In keeping with the role of PTCH as a tumor-suppressor gene, somatic mutations of this gene occur in sporadic basal-cell carcinomas and medulloblastomas. 12068298 Human
ptch rcc Our results suggest that LOH of the PTCH gene may be related to the development of nonpapillary RCC, although the clinical relevance has not been not clarified. 12378516 Human
ptch skin tumors Transcripts induced by the GLI transgene are likewise expressed in association with endogenous GLI in Ptch-deficient murine fibroblasts or in human skin tumors, but are not up-regulated in RK3E cells transformed by c-MYC, KLF4, or HRAS1. 12384550 Human
ptch fibrosarcomas Some ovarian fibromas and rare fibrosarcomas are associated with Gorlin syndrome, which is caused by mutation in the human homologue of Drosophila patched gene (PTCH), localized on chromosome 9q22.3. 16084949 Human
ptch tumorigenesis CONCLUSIONS: Because aberrant expressions of PTCH and Smo were common in human pancreatic carcinoma tissues and were associated with the low-level differentiation of tumor tissue and hyperglycemia, this indicated that these molecules played a fundamental 16804411 Human
ptch transitional carcinoma PTCH located at 9q22.3, as well as the TSC gene at 9q34 are involved in squamous cell carcinoma rather than transitional carcinoma. 17102820 Human
ptch adenocarcinoma Reproducible histopathological criteria for serrated adenocarcinoma have recently been established and they have been qualified by DNA expression analysis for 7928 genes, showing clustering of serrated adenocarcinomas into a molecular entity apart from co 17204027 Human
ptch adenocarcinomas Reproducible histopathological criteria for serrated adenocarcinoma have recently been established and they have been qualified by DNA expression analysis for 7928 genes, showing clustering of serrated adenocarcinomas into a molecular entity apart from co 17204027 Human
ptch conventional adenocarcinoma Reproducible histopathological criteria for serrated adenocarcinoma have recently been established and they have been qualified by DNA expression analysis for 7928 genes, showing clustering of serrated adenocarcinomas into a molecular entity apart from co 17204027 Human
the patched gene wilms tumor Rhabdomyosarcoma, Wilms tumor, and deletion of the patched gene in Gorlin syndrome. 17019435 Human
ptc astrocytic tumor In comparison with the World Health Organization (WHO) classification, the amount of Ptc and Smo mRNAs decreased in proportion to the progression of histological maliganancy, and similar results were obtained with astrocytic tumor-derived cell lines. 12241103 Human
ptc hcc Here we show that in HCCs, overexpression of the Smo proto-oncogene, as well as an increase in the stoichiometric ratio of Smo to Ptc mRNA levels, correlated with tumor size, a prognostic indicator in HCC biology. 16339184 Human
ptc hccs Here we show that in HCCs, overexpression of the Smo proto-oncogene, as well as an increase in the stoichiometric ratio of Smo to Ptc mRNA levels, correlated with tumor size, a prognostic indicator in HCC biology. 16339184 Human
ptc gastrointestinal stromal tumors (gists) AIM: To investigate the role that the hedgehog (Hh) signaling pathway, which includes sonic hedgehog (Shh), Patched (Ptc), Smoothened (Smo) and Gli-1, plays in human gastrointestinal stromal tumors (GISTs). 17007023 Human
ptc schwannomas METHODS: Surgically resected specimens from patients with GISTs, leiomyomas and schwannomas were examined by immunohistochemical staining for aberrant expression of hedgehog signaling components, Shh, Ptc, Smo and Gli-1, respectively. 17007023 Human
ptc schwannomas In schwannomas, 83.3% (5 of 6), 83.3% (5 of 6), 83.3% (5 of 6) and 100% (6 of 6) stained positive for Shh, Ptc, Smo and Gli-1, respectively. 17007023 Human
ptch1 hcc We detect expression of Shh, PTCH1 and Gli1 in 115 cases of HCC and in 44 liver tissues adjacent to the tumor. 16501253 Human
ptch1 hccs Consistent with this, hedgehog target genes PTCH1 and Gli1 are expressed in over 50% of the tumors, suggesting that the hedgehog pathway is frequently activated in HCCs. 16501253 Human
ptch1 glioma The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition. 16895439 Human
ptc1 teratoma Treatment of murine brain primary cultures and a human teratoma cell line with the N-terminal activated form of Shh (ShhNT), a Ptc1-Shh complex was observed in lysosomes. 10718318 Human

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