IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RASEF Ensembl ENSG00000165105 Chromosome 9 Start 84787144 End 84867863
Description RAS and EF-hand domain-containing protein (Ras-related protein Rab-45) [Source:UniProtKB/Swiss-Prot;Acc:Q8IZ41]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 26464
     Entrez Gene : 158158
     UCSC : uc004amo.1
     GeneCards : 26464
     RefSeq : NM_152573
     CCDS : CCDS6662.1
     Uniprot : Q8IZ41
     Interpro : Q8IZ41
     OMIM : 611344
     GeneTests : RASEF
     CGAP : RASEF
     PMID : 12477932

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.53 188 1 0.53 188 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16594 AD c.1048C>T p.H350Y Substitution - Missense Heterozygous 9:84810216-8481021618948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  1553185_at  0.82  2.44e-5  8.72e-5  1.94  4.28e-24  9.54e-23
 HG_U133_Plus2  1553186_x_at  0.98  5.75e-7  2.71e-6  2.32  6.73e-27  2.10e-25
 HG_U133_Plus2  1553986_at  -0.10  4.37e-1  5.27e-1  -1.14  2.27e-10  1.05e-9
 Agilent_HS_21.6K  9673  0.09  2.55e-1  4.39e-1  0.13  1.91e-1  3.32e-1

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 1553185_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1553186_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1553986_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9673    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rasef tumor Expression of RASEF, a known gene in this region, was examined in tumor tissue from 10 sporadic CMM lesions and was found to be decreased in 70% of these tumors compared with RASEF expression in a human reference RNA pool from 10 different cell types and 16174859 Human
rasef tumors Expression of RASEF, a known gene in this region, was examined in tumor tissue from 10 sporadic CMM lesions and was found to be decreased in 70% of these tumors compared with RASEF expression in a human reference RNA pool from 10 different cell types and 16174859 Human
rasef cmm Expression of RASEF, a known gene in this region, was examined in tumor tissue from 10 sporadic CMM lesions and was found to be decreased in 70% of these tumors compared with RASEF expression in a human reference RNA pool from 10 different cell types and 16174859 Human

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