IGDB.NSCLC Gene View
Gene Information
Somatic Mutations
Microarray Gene Expression Result
Microarray Sample Data
Cancer Gene Index
Gene Information
(help)
Gene
RASL10B
Ensembl
ENSG00000141150
Chromosome
17
Start
31082792
End
31094652
Description
Ras-like protein family member 10B Precursor (Ras-like protein VTS58635) [Source:UniProtKB/Swiss-Prot;Acc:Q96S79]
GENE RESOURCES :
NUCLEOTIDE SEQUENCES :
PROTEIN RESOURCES :
CLINICAL RESOURCES :
REFERENCES :
HGNC : 30295
Entrez Gene : 91608
UCSC : uc002hju.2
GeneCards : 30295
RefSeq : NM_033315
CCDS : CCDS11297.1
Uniprot : Q96S79
Interpro : Q96S79
OMIM : 612128
GeneTests : RASL10B
CGAP : RASL10B
PMID : 12477932
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Somatic Mutaions
(help)
Lung cancer
Adenocarcinoma
Squamous Cell Carcinoma
Unique Mutated Samples
% Mutated
Total Unique
Samples
Unique Mutated
Samples
% Mutated
Total Unique
Samples
Unique Mutated
Samples
% Mutated
Total Unique
Samples
1
8.33
12
1
100.00
1
0
0.00
0
Sample datas
Sample Name
Histology Subtype
DNA Mutation
Protein Mutation
Mutation Description
Zygosity
Genomic Co-ordinates NCBI36
Pubmed
NCI-H2122
AD
c.82G>A
p.E28K
Substitution - Missense
Heterozygous
17:31086398-31086398
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Microarray Gene Expression Fold Change Result
(help)
(
red: up-regulation
/
green : down-regulation
when p value < 0.01)
( gray background : these probesets might have mapping problems.
ref 1
,
ref 2
)
Chip Type
Probeset
Adenocarcinoma
Squamous Cell Carcinoma
Fold Change
p value
q value
Fold Change
p value
q value
HG_U133_Plus2
235488_at
0.31
8.15e-2
1.29e-1
0.60
1.23e-3
2.33e-3
HG_U133_Plus2
244656_at
0.18
2.24e-1
3.04e-1
0.31
4.83e-2
6.93e-2
Agilent_HS_21.6K
18893
-0.03
9.30e-2
2.24e-1
-0.04
1.52e-2
4.99e-2
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Microarray Sample Data
(help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
HG_U133_Plus2
- 235488_at
(back)
HG_U133_Plus2
- 244656_at
(back)
Agilent_HS_21.6K
- 18893
(back)
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Cancer Gene Index
(help)
If 0 entry was found, please remove the search key "lung cancer".
Keyword
DiseaseData
Statement
PubMed
Organism
rasl10b
tumor
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
17028781
Human
rasl10b
human breast cancer
Finally, the mRNA levels of RasL10B were down-regulated in all human breast cancer cell lines we tested.
17028781
Human
rasl10b
tumor
In summary, RasL10B is a new member of Ras superfamily with tumor suppressor potential.
17028781
Human
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