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Somatic Mutations

Microarray Gene Expression Result

Microarray Sample Data

Cancer Gene Index

Gene Information (help)

Gene

RASL10B

Ensembl

ENSG00000141150

Chromosome

Start

31082792

End

31094652

Description

Ras-like protein family member 10B Precursor (Ras-like protein VTS58635) [Source:UniProtKB/Swiss-Prot;Acc:Q96S79]

GENE RESOURCES :	NUCLEOTIDE SEQUENCES :	PROTEIN RESOURCES :	CLINICAL RESOURCES :	REFERENCES :
HGNC : 30295 Entrez Gene : 91608 UCSC : uc002hju.2 GeneCards : 30295	RefSeq : NM_033315 CCDS : CCDS11297.1	Uniprot : Q96S79 Interpro : Q96S79	OMIM : 612128 GeneTests : RASL10B CGAP : RASL10B	PMID : 12477932

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Somatic Mutaions (help)
Lung cancer			Adenocarcinoma			Squamous Cell Carcinoma
Unique Mutated Samples	% Mutated	Total Unique Samples	Unique Mutated Samples	% Mutated	Total Unique Samples	Unique Mutated Samples	% Mutated	Total Unique Samples
1	8.33	12	1	100.00	1	0	0.00	0
Sample datas
Sample Name	Histology Subtype	DNA Mutation	Protein Mutation	Mutation Description	Zygosity	Genomic Co-ordinates NCBI36	Pubmed
NCI-H2122	AD	c.82G>A	p.E28K	Substitution - Missense	Heterozygous	17:31086398-31086398

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Microarray Gene Expression Fold Change Result (help) ( red: up-regulation / green : down-regulation when p value < 0.01) ( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type	Probeset	Adenocarcinoma			Squamous Cell Carcinoma
Chip Type	Probeset	Fold Change	p value	q value	Fold Change	p value	q value
HG_U133_Plus2	235488_at	0.31	8.15e-2	1.29e-1	0.60	1.23e-3	2.33e-3
HG_U133_Plus2	244656_at	0.18	2.24e-1	3.04e-1	0.31	4.83e-2	6.93e-2
Agilent_HS_21.6K	18893	-0.03	9.30e-2	2.24e-1	-0.04	1.52e-2	4.99e-2

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Microarray Sample Data (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)

HG_U133_Plus2 - 235488_at (back)

HG_U133_Plus2 - 244656_at (back)

Agilent_HS_21.6K - 18893 (back)

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Cancer Gene Index (help)

If 0 entry was found, please remove the search key "lung cancer".

Keyword DiseaseData Statement PubMed Organism

rasl10b tumor Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. 17028781 Human

rasl10b human breast cancer Finally, the mRNA levels of RasL10B were down-regulated in all human breast cancer cell lines we tested. 17028781 Human

rasl10b tumor In summary, RasL10B is a new member of Ras superfamily with tumor suppressor potential. 17028781 Human

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