IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RASL10B Ensembl ENSG00000141150 Chromosome 17 Start 31082792 End 31094652
Description Ras-like protein family member 10B Precursor (Ras-like protein VTS58635) [Source:UniProtKB/Swiss-Prot;Acc:Q96S79]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 30295
     Entrez Gene : 91608
     UCSC : uc002hju.2
     GeneCards : 30295
     RefSeq : NM_033315
     CCDS : CCDS11297.1
     Uniprot : Q96S79
     Interpro : Q96S79
     OMIM : 612128
     GeneTests : RASL10B
     CGAP : RASL10B
     PMID : 12477932

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 8.33 12 1 100.00 1 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
NCI-H2122 AD c.82G>A p.E28K Substitution - Missense Heterozygous 17:31086398-31086398 

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133_Plus2  235488_at  0.31  8.15e-2  1.29e-1  0.60  1.23e-3  2.33e-3
 HG_U133_Plus2  244656_at  0.18  2.24e-1  3.04e-1  0.31  4.83e-2  6.93e-2
 Agilent_HS_21.6K  18893  -0.03  9.30e-2  2.24e-1  -0.04  1.52e-2  4.99e-2

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133_Plus2 - 235488_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 244656_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18893    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rasl10b tumor Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. 17028781 Human
rasl10b human breast cancer Finally, the mRNA levels of RasL10B were down-regulated in all human breast cancer cell lines we tested. 17028781 Human
rasl10b tumor In summary, RasL10B is a new member of Ras superfamily with tumor suppressor potential. 17028781 Human

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