IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ROR2 Ensembl ENSG00000169071 Chromosome 9 Start 93365194 End 93752265
Description Tyrosine-protein kinase transmembrane receptor ROR2 Precursor (EC 2.7.10.1)(Neurotrophic tyrosine kinase, receptor-related 2) [Source:UniProtKB/Swiss-Prot;Acc:Q01974]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10257
     Entrez Gene : 4920
     UCSC : uc004arj.1
     GeneCards : 10257
     RefSeq : NM_004560
     CCDS : CCDS6691.1
     Uniprot : Q01974
     Interpro : Q01974
     OMIM : 602337
     GeneTests : ROR2
     CGAP : ROR2
     PMID : 1334494

< Top >


Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
6 2.67 225 5 2.56 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16628 AD c.2183G>C p.C728S Substitution - Missense Heterozygous 9:93526414-9352641418948947
16686 AD c.1741C>G p.R581G Substitution - Missense Heterozygous 9:93526856-9352685618948947
16734 AD c.2395C>T p.P799S Substitution - Missense Heterozygous 9:93526202-9352620218948947
16881 AD c.2362G>T p.G788W Substitution - Missense Heterozygous 9:93526235-9352623518948947
17242 AD c.2482C>A p.P828T Substitution - Missense Heterozygous 9:93526115-9352611518948947

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  212_at  0.59  7.09e-4  2.32e-3  0.78  1.93e-3  5.50e-3
 HG_U133A  205578_at  -0.01  9.52e-1  9.59e-1  0.78  2.24e-6  2.64e-6
 HG_U133_Plus2  205578_at  -0.33  7.02e-2  1.13e-1  0.36  8.18e-2  1.12e-1
 Stanford  4545  -0.82  6.76e-2  1.90e-1  -0.32  3.51e-1  5.90e-1
 Agilent_HS_21.6K  9195  -0.01  8.46e-1  9.14e-1  0.01  6.94e-1  8.00e-1

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205578_at  0.35  3.51e-1  8.90e-1  0.13  6.96e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 212_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205578_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205578_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4545    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9195    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ror2 human neuroblastoma BACKGROUNDS: Drosophila neurospecific receptor tyrosine kinases (RTKs), Dror and Dnrk, as well as Ror1 and Ror2 RTKs, isolated from human neuroblastoma, have been identified as a structurally related novel family of RTKs (Ror-family RTKs). 10231392 Human
ror2 nevoid-basal-cell-carcinoma syndrome (nbccs) Mutations of the former cause the nevoid basal cell carcinoma syndrome (NBCCS) while mutations in the ROR2 gene have been found both in Robinow syndrome and in brachydactyly type 1B (BDB1). 12548386 Human
bdb1 nevoid-basal-cell-carcinoma syndrome (nbccs) Mutations of the former cause the nevoid basal cell carcinoma syndrome (NBCCS) while mutations in the ROR2 gene have been found both in Robinow syndrome and in brachydactyly type 1B (BDB1). 12548386 Human
ror2 chondrosarcoma Rat Ror1 mRNA was expressed in fetal ventricle, while rat Ror2 mRNA was expressed in cerebral cortex, hypothalamus, dorsolateral prostate, and chondrosarcoma. 15702250 Rat

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.