IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SHC3 Ensembl ENSG00000148082 Chromosome 9 Start 90817891 End 90983502
Description SHC-transforming protein 3 (Src homology 2 domain-containing-transforming protein C3)(SH2 domain protein C3)(Neuronal Shc)(N-Shc)(Protein Rai) [Source:UniProtKB/Swiss-Prot;Acc:Q92529]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 18181
     Entrez Gene : 53358
     UCSC : uc004aqg.2
     GeneCards : 18181
     RefSeq : NM_016848
     CCDS : CCDS6681.1
     Uniprot : Q92529
     Interpro : Q92529
     OMIM : 605263
     GeneTests : SHC3
     CGAP : SHC3
     PMID : 8808684

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
2 1.01 199 1 0.53 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16802 AD c.162_163ins12 p.R54_K55insEALR Insertion - In frame Heterozygous 9:90983033-9098303418948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1511_at  -0.52  8.13e-4  2.62e-3  -1.15  7.51e-7  4.81e-6
 HG_U133A  206330_s_at  -0.89  4.74e-11  1.85e-10  0.75  2.12e-8  2.58e-8
 HG_U133_Plus2  206330_s_at  -1.68  4.68e-14  5.67e-13  -2.41  1.28e-22  2.40e-21
 Stanford  12119  -0.96  1.96e-2  9.94e-2  -1.04  2.26e-2  1.16e-1
 Agilent_HS_21.6K  20864  -0.11  5.09e-2  1.47e-1  -0.14  1.16e-2  4.05e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206330_s_at  0.07  8.21e-1  9.84e-1  -0.27  7.99e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1511_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206330_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206330_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12119    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20864    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
shcc neuroblastoma Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. 12185581 Human
shcc neuroblastoma In most of neuroblastoma cells, obvious tyrosine phosphorylation of ShcC was observed, whereas expression of ShcB was considerably low. 12185581 Human
shcc neuroblastoma Phosphoproteins associated with hyperphosphorylated ShcC were purified from neuroblastoma cell lines, and identified by mass-spectrometry. 12185581 Human
shcc neuroblastoma Anaplastic lymphoma kinase (ALK), which turned out to be one of these phosphoproteins, was constitutively activated and associated with the PTB domain of ShcC in three neuroblastoma cells. 12185581 Human
shc3 astrocytomas Shc3 affects human high-grade astrocytomas survival. 15870690 Human
shc3 glioblastomas We now show that in human astrocytomas and glioblastomas, the normal pattern of expression of Shc1/Shc3 is totally subverted, both proteins being present at the same time and in the same cells. 15870690 Human
shc3 astrocytomas We now show that in human astrocytomas and glioblastomas, the normal pattern of expression of Shc1/Shc3 is totally subverted, both proteins being present at the same time and in the same cells. 15870690 Human
shc3 tumor Our data indicate that Shc3 is maximally expressed, together with Shc1, in glioblastoma, a highly proliferative tumor with little, if any, indication of neuronal differentiation. 15870690 Human
shc3 glioblastoma Our data indicate that Shc3 is maximally expressed, together with Shc1, in glioblastoma, a highly proliferative tumor with little, if any, indication of neuronal differentiation. 15870690 Human
shc3 tumor In primary cultures of glioblastoma, tumor cells maintain Shc1 expression but downregulate Shc3. 15870690 Human
shc3 glioblastoma In primary cultures of glioblastoma, tumor cells maintain Shc1 expression but downregulate Shc3. 15870690 Human
shc3 tumor Analysis of the phosphorylation status of Shc3 in human glioblastoma tumor samples in vivo indicates that it is tyrosine phosphorylated. 15870690 Human
shc3 glioblastoma Analysis of the phosphorylation status of Shc3 in human glioblastoma tumor samples in vivo indicates that it is tyrosine phosphorylated. 15870690 Human
shc3 high-grade glioma Finally, we found that the expression of truncated variants of Shc3 with dominant-negative effects in human high-grade glioma cells that maintain Shc3 expression in vitro leads to a decreased Akt posphorylation and increased apoptosis, thus resulting in i 15870690 Human
shcc neuroblastoma Domain-specific function of ShcC docking protein in neuroblastoma cells. 15735675 Human
shcc neuroblastoma We have recently shown that some neuroblastoma cell lines, such as NB-39-nu cells, express a protein complex of hyperphosphorylated ShcC and anaplastic lymphoma kinase (ALK), which is self-activated by gene amplification. 15735675 Human
shcc neuroblastoma Reciprocal change of ShcC expression and phosphorylation observed in malignant neuroblastoma cell lines might be explained by these phosphotyrosine-dependent and -independent functions of ShcC. 15735675 Human
shcc neuroblastoma Shc Family Expression in Neuroblastoma: High Expression of shcC Is Associated with a Poor Prognosis in Advanced Neuroblastoma. 15867224 Human
shcc neuroblastoma Because the Shc family proteins (ShcA, ShcB, and ShcC) are adaptors for various receptors, including Trk receptors, and are regulators of neuronal cell development, we speculated that they may play a role in neuroblastoma. 15867224 Human
shcc neuroblastoma Finally, the expression of shcC was observed in most of the neuroblastoma cell lines and in some stage 4 patients. 15867224 Human
shcc tumor Therefore, ShcC seems to be associated with an aggressive tumor phenotype, perhaps by enhancing TrkB signals. 15867224 Human
shcc neuroblastoma Our results suggest that the expressions of shcB and shcC are important biological factors in neuroblastoma and are useful prognostic indicators. 15867224 Human
shcc neuroblastoma The suppression of activated ALK in neuroblastoma cells by RNA interference significantly reduced the phosphorylation of ShcC, mitogen-activated protein kinases, and Akt, inducing rapid apoptosis in the cells. 15972965 Human

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