IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC2A1 Ensembl ENSG00000117394 Chromosome 1 Start 43164115 End 43197126
Description Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain)(GLUT-1)(HepG2 glucose transporter) [Source:UniProtKB/Swiss-Prot;Acc:P11166]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11005
     Entrez Gene : 6513
     UCSC : uc001cik.2
     GeneCards : 11005
     RefSeq : NM_006516
     CCDS : CCDS477.1
     Uniprot : P11166
     Interpro : P11166
     OMIM : 138140
     GeneTests : SLC2A1
     CGAP : SLC2A1
     PMID : 8839927

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 239/289(83%) IHC- 9305704 Cancer. 1997 Sep 15;80(6):1046-51.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40507_at  0.43  7.40e-6  3.96e-5  0.80  7.44e-6  3.87e-5
 HG_U133A  201249_at  0.06  5.32e-1  5.84e-1  3.83  4.31e-93  2.42e-92
 HG_U133A  201250_s_at  0.99  9.57e-23  9.16e-22  3.24  1.54e-116  1.66e-115
 HG_U133_Plus2  201249_at  1.51  5.51e-13  5.85e-12  3.62  7.03e-38  9.19e-36
 HG_U133_Plus2  201250_s_at  1.94  2.96e-31  2.36e-29  3.96  1.48e-59  4.06e-55
 Stanford  14445  2.92  5.69e-5  2.22e-3  4.56  5.41e-9  2.84e-6
 Agilent_HS_21.6K  18078  0.67  5.97e-4  5.03e-3  1.54  1.72e-11  1.26e-9

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201249_at  0.05  8.74e-1  9.91e-1  0.11  5.90e-1  1.00e+0
 HG_U133A  201250_s_at  0.29  3.21e-1  8.82e-1  0.04  8.62e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40507_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201249_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201250_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201249_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201250_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 14445    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18078    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
glut1 brain cancer These results identify the AURE cis element in human GLUT1 mRNA and show that hnRNP A2 acts on GLUT1 mRNA to inhibit expression of GLUT1 in a brain cancer cell line. 15147968 Human
glut1 borderline tumors GLUT1 staining is absent in benign ovarian epithelial tumors, and shows progressively more staining in invasive tumors as compared to borderline tumors. 11920478 Human
glut1 ovarian epithelial tumors GLUT1 staining is absent in benign ovarian epithelial tumors, and shows progressively more staining in invasive tumors as compared to borderline tumors. 11920478 Human
glut1 gallbladder carcinomas Expression of the GLUT1 glucose transporter in gallbladder carcinomas. 12143238 Human
glut1 invasive breast carcinomas One hundred consecutive formalin-fixed, paraffin-embedded sections of invasive breast carcinomas were evaluated by means of immunohistochemical staining of GLUT1. 12417042 Human
glut1 thyroid neoplasms RESULTS: Expression of GLUT1 transporter on the cell membrane was closely related to the grade of malignancy in thyroid neoplasms (Fisher exact test p < 0.05). 12481939 Human
glut1 anaplastic tumors All anaplastic tumors showed a high level of GLUT1 expression in the cytoplasm and on the cell membrane. 12481939 Human
glut1 thyroid neoplasms CONCLUSIONS: These data indicate that overexpression of GLUT1 on the cell membrane of thyroid neoplasms is closely related to tumors demonstrating a more aggressive biological behavior. 12481939 Human
glut1 hypopharyngeal carcinoma MATERIALS AND METHODS: We investigated the incidence of Glut1 expression by immunostaining in 99 patients with hypopharyngeal carcinoma, and revealed the correlation with the clinical characteristics. 12552944 Human
glut1 hypopharyngeal carcinoma CONCLUSION: Glut1 expression is an indicator for predicting the prognosis of hypopharyngeal carcinoma. 12552944 Human
glut1 colorectal adenomas The aim of the present study was to investigate the expression of Glut1 protein in colorectal adenomas, T1 and T2 stage carcinomas. 11166147 Human
glut1 transitional cell carcinoma Glut1 has been shown to be expressed in many human cancers, including transitional cell carcinoma of the urinary bladder (TCCB). 11299807 Human
glut1 invasive carcinomas Statistical analysis revealed association between invasive carcinomas, invasive carcinomas with in situ component and GLUT1 immunostaining. 11447743 Human
glut1 human gastric carcinoma Expression of Glut1, one of the Gluts, has been described in malignancies of the esophagus, colon, pancreas, lung, and brain, but to the authors' knowledge the significance of Glut1 expression in human gastric carcinoma has not been elucidated. 11505409 Human
glut1 gastric carcinoma The objective of the current study was to examine the expression and distribution of Glut1 and its relation to clinicopathologic parameters in patients with gastric carcinoma. 11505409 Human
glut1 papillary adenocarcinoma Signet ring cell carcinoma and mucinous adenocarcinoma rarely were positive (2.0% and 6.3%, respectively) and papillary adenocarcinoma (44%) showed slightly higher positivity for Glut1 than tubular (32%) or poorly differentiated adenocarcinoma (28%). 11505409 Human
glut1 signet-ring-cell carcinoma Signet ring cell carcinoma and mucinous adenocarcinoma rarely were positive (2.0% and 6.3%, respectively) and papillary adenocarcinoma (44%) showed slightly higher positivity for Glut1 than tubular (32%) or poorly differentiated adenocarcinoma (28%). 11505409 Human
glut1 mucinous adenocarcinoma Signet ring cell carcinoma and mucinous adenocarcinoma rarely were positive (2.0% and 6.3%, respectively) and papillary adenocarcinoma (44%) showed slightly higher positivity for Glut1 than tubular (32%) or poorly differentiated adenocarcinoma (28%). 11505409 Human
glut1 hepatic metastasis Glut1 positivity was associated with depth of invasion (P = 0.0001), lymphatic permeation (P = 0.0001), venous invasion (P = 0.0001), lymph node metastasis (P = 0.0001), hepatic metastasis (P = 0.0001), and carcinoma stage (P = 0.0001). 11505409 Human
glut1 human gastric carcinoma CONCLUSIONS: In human gastric carcinoma, Glut1 is expressed late in carcinogesis and increases with disease progression. 11505409 Human
glut1 choriocarcinoma We analyzed whether placental GLUT1 and GLUT3 expression changes during differentiation using a human choriocarcinoma (BeWo) cell line which is known to show functional and morphological differentiation in response to cAMP in culture. 10657852 Human
glut1 pyogenic granulomas No endothelial GLUT1 immunoreactivity was found in any of 66 vascular malformations (17 arteriovenous, 33 venous, 11 lymphatic, and 5 port-wine) from patients aged 5 days to 75 years, or in any of 20 pyogenic granulomas or 7 granulation tissue specimens. 10665907 Human
glut1 infantile hemangioma GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. 14991538 Human
glut1 metaplasia Relationship between dysplasia, p53 protein accumulation, DNA ploidy, and Glut1 overexpression in Barrett metaplasia. 10720109 Human
glut1 endometrial carcinomas PURPOSE: To explore the expression of fatty acid synthase (FAS) and human erythrocyte glucose transporter 1 (GLUT1) in endometrial carcinomas and to detect associations with clinicopathological features and prognosis. 14751145 Human
glut1 colon cancer By contrast, GLUT1 mRNA was detected in all 20 (100%) colon cancer samples examined. 10806301 Human
glut1 colon cancer Thus, a major difference between normal colon epithelia and colon cancer was the acquisition of GLUT1 expression, which was unlikely to have been induced by a point mutation in codon 12 of k-ras. 10806301 Human
glut1 endometrial hyperplasias Simple and complex endometrial hyperplasias were consistently GLUT1 negative. 10870060 Human
glut1 atypical hyperplasia All specimens of atypical hyperplasia had foci that were positive for GLUT1. 10870060 Human
glut1 endometrial adenocarcinomas All endometrial adenocarcinomas were GLUT1 positive. 10870060 Human
glut1 atypical hyperplasia CONCLUSIONS: The results of the current study appear to indicate that 1) aberrant overexpression of GLUT1 is a consistent feature of endometrioid adenocarcinoma; 2) GLUT1 immunostaining may be useful in distinguishing benign hyperplasias from hyperplasias 10870060 Human
glut1 endometrioid adenocarcinoma CONCLUSIONS: The results of the current study appear to indicate that 1) aberrant overexpression of GLUT1 is a consistent feature of endometrioid adenocarcinoma; 2) GLUT1 immunostaining may be useful in distinguishing benign hyperplasias from hyperplasias 10870060 Human
glut1 gastric adenocarcinoma We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. 10983690 Human
glut1 metaplasia By immunohistochemistry, GLUT1 protein was absent in normal gastric epithelium and intestinal metaplasia. 10983690 Human
glut1 gastric adenocarcinoma 11 of 65 patients with gastric adenocarcinoma had specific GLUT1 immunostaining in a plasma membrane pattern with varied intensities. 10983690 Human
glut1 human esophageal carcinomas The aim of this work was to determine whether the neutral amino acid transporter ASCT1 is expressed in human esophageal carcinomas, and to correlate the findings with Glut1 expression. 11268453 Human
glut1 smooth muscle tumors In addition to clinical staging, Glut1 positivity together with patterns of immunoreactivity of CD44 and bcl2 may be helpful in identifying aggressive smooth muscle tumors of the uterus and some EULMS. 10574596 Human
glut1 metastatic liver tumors The aim of this study was to investigate the gene expression levels of the GLUT family, especially GLUT1, GLUT3, and GLUT5 in primary lung cancer, metastatic liver tumors, and normal lung tissues, and to compare the expression levels of primary and metast 10622535 Human
glut1 primary lung tumors The GLUT1 gene expression levels in primary lung tumors were significantly higher than those in normal lung tissues. 10622535 Human
glut1 primary lung tumors In liver metastatic lesions, the GLUT3 and GLUT5 gene expression levels were significantly higher than those in primary lung tumors, but there were no differences in GLUT1 expression levels between primary and metastatic liver tumors. 10622535 Human
glut1 metastatic liver tumors In liver metastatic lesions, the GLUT3 and GLUT5 gene expression levels were significantly higher than those in primary lung tumors, but there were no differences in GLUT1 expression levels between primary and metastatic liver tumors. 10622535 Human
glut1 human insulinoma The aim of our study was to investigate, under different experimental conditions, the capacity of the human insulinoma cell line CM to retain beta-cell function, particularly the expression of constitutive beta-cell genes (insulin, the glucose transporter 10194529 Human
glut1 hepatoma We used mouse hepatoma (Hepa1c1c7) cells to study the role of the serine/threonine kinase Akt in the induction of GLUT1 gene expression. 10400647 Human
glut1 adenocarcinoma of the lung GLUT1 expression in adenocarcinoma of the lung is correlated with reduced cell differentiation, larger tumor size and positive lymph node metastasis. 10425560 Human
glut1 thyroid carcinomas The expression of 4 thyroid tissue-specific genes [Na+/I- symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (Tg), TSH receptor (TSH-R)] as well as of the glucose transporter type 1 (Glut1) gene was analyzed in 90 human thyroid tissues Messenger rib 10487692 Human
glut1 thyroid carcinomas Expression of the Glut1 gene was increased in 1 of 24 adenomas and in 8 of 43 thyroid carcinomas. 10487692 Human
glut1 hemangioblastoma In comparison with previous studies of human brain capillaries in hemangioblastoma and brain injury, endothelial Glut1 density was apparently reduced (interictally) in affected temporal lobes of patients with complex partial seizures. 9428303 Human
glut1 invasive ductal carcinomas To investigate the relation between necrosis and hypoxia in breast cancer we examined the expression of hypoxia-associated markers HIF1, CA IX and GLUT1 by immunohistochemistry in 97 invasive ductal carcinomas. 14531498 Human
glut1 tubular adenomas RESULTS: GLUT1 immunostaining was absent in normal colorectal epithelium and tubular adenomas, and absent or only weakly apparent in tubulovillous adenomas. 9655290 Human
glut1 tubulovillous adenomas RESULTS: GLUT1 immunostaining was absent in normal colorectal epithelium and tubular adenomas, and absent or only weakly apparent in tubulovillous adenomas. 9655290 Human
glut1 colon carcinoma In a multivariate analysis to assess whether high GLUT1 staining correlated with increased mortality independently of Dukes stage, the risk of death from colon carcinoma in the group with high GLUT1 staining was 2.3 times that in the group with low GLUT1 9655290 Human
glut1 tumor Reintroduction of the 18-kDa VHL gene product into renal carcinoma cells lacking wild-type VHL protein led to down-regulation of vascular endothelial growth factor (VEGF) mRNA and glucose transporter GLUT1 protein and suppressed tumor formation in nude mi 9671762 Human
glut1 renal carcinoma Reintroduction of the 18-kDa VHL gene product into renal carcinoma cells lacking wild-type VHL protein led to down-regulation of vascular endothelial growth factor (VEGF) mRNA and glucose transporter GLUT1 protein and suppressed tumor formation in nude mi 9671762 Mouse
glut1 hepatoma In most hepatoma cells, the high-Km GLUT2/glucokinase proteins are replaced by the ubiquitous low-Km GLUT1/hexokinase type I proteins. 9748301 Human
glut1 choriocarcinoma Immunocytochemically, choriocarcinoma cells expressed the high-affinity glucose transporter isoforms GLUT1 and GLUT3. 9766571 Human
glut1 choriocarcinoma We conclude that sustained hyperglycemia stimulates the glucose-transport system of JAR, but not of JEG-3, choriocarcinoma cells in vitro due to changes in GLUT1 and GLUT3 expression levels. 9766571 Human
glut1 choriocarcinoma Neither GLUT1 expression in JAr and JEG-3 choriocarcinoma cells nor transport activity in JEG-3 cells was affected by extracellular glucose concentration. 9778125 Human
glut1 murine erythroleukaemia Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3. 9010020 Mouse
glut1 lung cancer To examine the role of elevated glucose uptake in lung cancer, we performed PCR amplification of 2 facilitative glucose transporter genes (GLUT1 and GLUT3) and immunohistochemical staining for GLUT1, proliferating cell nuclear antigen (PCNA), and sialyl L 9133454 Human
glut1 lung cancer Our results suggest that GLUT1 amplification may participate in sLe(x) synthesis as well as in proliferation, and may be of prognostic value in lung cancer. 9133454 Human
glut1 metaplasia Human erythrocyte glucose transporter (Glut1) is immunohistochemically detected as a late event during malignant progression in Barrett's metaplasia. 9149888 Human
glut1 metaplasia We have previously demonstrated that the human erythrocyte glucose transporter (Glut1) is expressed in adenocarcinoma arising in Barrett's metaplasia (BM). 9149888 Human
glut1 metaplasia The aim of this work was to determine the chronology of Glut1 expression during the neoplastic progression in Barrett's metaplasia. 9149888 Human
glut1 hemangioblastoma The 80-kDa protein is selectively expressed in hemangioblastoma, a tumor characterized by overexpression of GLUT1. 9166756 Human
glut1 choriocarcinoma Expression of the facilitated glucose transporters (GLUT1 and GLUT3) by a choriocarcinoma cell line (JAr) and cytotrophoblast cells in culture. 9179927 Human
glut1 penile carcinoma This study was performed to evaluate the expression of GLUT1 in penile proliferative lesions (18 cases of penile carcinoma and 13 cases of condyloma acuminatum). 9184841 Human
glut1 condyloma acuminatum This study was performed to evaluate the expression of GLUT1 in penile proliferative lesions (18 cases of penile carcinoma and 13 cases of condyloma acuminatum). 9184841 Human
glut1 penile carcinoma In all cases of penile carcinoma, GLUT1 staining was diffusely recognized on the cell membrane of the carcinoma cells in the mainly infiltrating areas. 9184841 Human
glut1 penile carcinoma In conclusion, GLUT1 is expressed dominantly in penile proliferative lesions, especially in infiltrating areas of penile carcinoma. 9184841 Human
glut1 papillary carcinoma Tumor cell GLUT1 staining was seen in two patterns: circumferential plasma membrane staining focally within the tumor, or asymmetric staining of the basilar aspect of tumor cells adjacent to stroma in some cases of papillary carcinoma. 9226204 Human
glut1 oral carcinoma Expression of GLUT1 in stratified squamous epithelia and oral carcinoma from humans and rats. 9269300 Human
glut1 oral carcinoma To further clarify these issues, we examined the distribution of GLUT1 and GLUT4 in skin, different types of oral mucosa from rat and man, and a human oral carcinoma by indirect immunofluorescence microscopy. 9269300 Human
glut1 oral carcinoma GLUT1 was also expressed in ductal- and myoepithelial cells of minor salivary glands and perineural sheath located in the lamina propra, and furthermore in the cells of an oral carcinoma. 9269300 Human
glut1 nonsmall-cell lung carcinoma Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. 9305704 Human
glut1 nonsmall-cell lung carcinoma (nsclc) BACKGROUND: Increased expression of Glut1 and Glut3 has been reported in many human cancers, including nonsmall cell lung carcinoma (NSCLC). 9305704 Human
glut1 ehrlich ascites tumor We found that Ehrlich ascites tumor cells possess only glucose transporter 1 (GLUT1) and GLUT3 but not GLUT2, GLUT4, or GLUT5. 9328846 Mouse
glut1 seborrheic keratoses METHODS: A polyclonal anti-Glut1 antibody (MYM) and a standard ABC immunoperoxidase technique were used to determine Glut1 expression in invasive squamous cell carcinomas (SCCs), SCC in situ, basal cell carcinomas (BCCs), melanomas, actinic keratoses (AKs 9344196 Human
glut1 melanomas METHODS: A polyclonal anti-Glut1 antibody (MYM) and a standard ABC immunoperoxidase technique were used to determine Glut1 expression in invasive squamous cell carcinomas (SCCs), SCC in situ, basal cell carcinomas (BCCs), melanomas, actinic keratoses (AKs 9344196 Human
glut1 basal-cell carcinomas (bccs) METHODS: A polyclonal anti-Glut1 antibody (MYM) and a standard ABC immunoperoxidase technique were used to determine Glut1 expression in invasive squamous cell carcinomas (SCCs), SCC in situ, basal cell carcinomas (BCCs), melanomas, actinic keratoses (AKs 9344196 Human
glut1 metaplasia Glut1 staining was present in the epidermis of 8 of 15 scars (53%) but was not detected in any BCC, even in areas of focal keratinization and squamous metaplasia. 9344196 Human
glut1 seborrheic keratoses Glut1 reactivity was absent in the melanomas and seborrheic keratoses. 9344196 Human
glut1 melanomas Glut1 reactivity was absent in the melanomas and seborrheic keratoses. 9344196 Human
glut1 metastatic renal-cell carcinoma GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. 14606586 Human
glut1 hemangioblastoma GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. 14606586 Human
glut1 hemangioblastoma CONCLUSION: that GLUT1 immunoreactivity patterns reliably distinguish hemangioblastoma from RCC. 14606586 Human
glut1 bladder cancer GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. 14520462 Human
glut1 bladder cancer This study directly compares CAIX and GLUT1 with pimonidazole binding in a prospective series of bladder cancer patients and also studies the prognostic significance of the markers, in combination with vascularity and proliferation, in a retrospective ser 14520462 Human
glut1 epithelial tumors Using immunohistochemistry, we found that Glut1 is largely undetectable in normal epithelial tissues and benign epithelial tumors but is expressed in a significant proportion of a variety of human carcinomas. 8640778 Human
glut1 carcinomas Using immunohistochemistry, we found that Glut1 is largely undetectable in normal epithelial tissues and benign epithelial tumors but is expressed in a significant proportion of a variety of human carcinomas. 8640778 Human
glut1 carcinomas We hypothesize that Glut1 expression by human carcinomas indicates an increased glucose uptake, and probably increased utilization of energy, which may correlate with an aggressive behavior. 8640778 Human
glut1 hemangioblastoma Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. 8675694 Human
glut1 hemangioblastoma The glucose transporter 1 (GLUT1) protein is underexpressed in human glioblastoma multiforme and is overexpressed in human cerebral hemangioblastoma. 8675694 Human
glut1 renal carcinoma Renal carcinoma cells lacking wild-type pVHL were found to produce mRNAs encoding VEGF/VPF, the glucose transporter GLUT1, and the platelet-derived growth factor B chain under both normoxic and hypoxic conditions. 8855223 Human
glut1 colon cancer Although studies have revealed increased expression of Glut1 mRNA in colon cancer, Glut1 protein (Glut1) expression in the large intestine and its significance are still unknown. 9816281 Human
glut1 colorectal neoplasms The objective of this work was to determine whether Glut1 is present in human colorectal neoplasms and whether that presence is of biological significance. 9816281 Human
glut1 hyperplastic polyps No Glut1 immunoreactivity was present in normal colonic mucosa or in hyperplastic polyps, whereas 8 (10%) of 82 adenomas showed such immunoreactivity. 9816281 Human
glut1 colorectal adenocarcinomas Forty-four (83%) of 53 colorectal adenocarcinomas expressed Glut1, and, of these, tumors in which >50% of the cancer cells expressed Glut1 had a significantly higher incidence of metastasis to the lymph nodes (P = 0.0001). 9816281 Human
glut1 human colorectal cancer It is concluded that (a) Glut1 is expressed as a late event in the carcinogenesis process in human colorectal cancer, and (b) expression of Glut1 in a high proportion of cancer cells is associated with a high incidence of lymph node metastases. 9816281 Human
glut1 lymph-node metastases It is concluded that (a) Glut1 is expressed as a late event in the carcinogenesis process in human colorectal cancer, and (b) expression of Glut1 in a high proportion of cancer cells is associated with a high incidence of lymph node metastases. 9816281 Human
glut1 renal-cell carcinoma The localization of 2 isoforms of glucose transporters (GLUT1 and GLUT4) in 75 patients with renal cell carcinoma was examined immunohistochemically. 7861542 Human
glut1 choroid plexus papillomas Immunohistochemical localization of the glucose transporter GLUT1 in choroid plexus papillomas. 7795732 Human
glut1 choroid plexus papillomas Normal chroid plexus tissue and five choroid plexus papillomas were examined with antibody specific for the glucose transporter GLUT1, one isoform of facilitated-diffusion glucose transporters, using the avidin-biotin-peroxidase complex (ABC) technique. 7795732 Human
glut1 choroid plexus papilloma Our results suggest that GLUT1 expression in the choroid plexus is restrained during the course of transformation and that choroid plexus papilloma is composed of various differentiation tumor cells. 7795732 Human
glut1 hemangioblastoma High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium. 7595657 Human
glut1 perineurioma Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. 12836021 Human
glut1 perineurioma We also observed that the tumor cells were positive for the human erythrocyte glucose transporter (GLUT1) antigen, suggesting that GLUT1 may be a useful marker for the identification of sclerosing perineurioma. 12836021 Human
glut1 breast tumors Breast tumors show increased expression of the glucose transporter GLUT1. 12960090 Human
glut1 insulinoma In the current study, we have used insulinoma (RIN) and AtT-20ins cell lines engineered for overexpression of GLUT2 or GLUT1 to investigate the role of glucose transporter isoforms in mediating STZ cytotoxicity. 7926307 Human
glut1 meningiomas The GLUT1/actin mRNA ratio increased in parallel to the astrocytoma grade, compared to a control human brain cortex, although no change in this ratio was seen in 5 meningiomas. 7877454 Human
glut1 astrocytoma The GLUT1/actin mRNA ratio increased in parallel to the astrocytoma grade, compared to a control human brain cortex, although no change in this ratio was seen in 5 meningiomas. 7877454 Human
glut1 prostate carcinoma Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. 12673735 Human
glut1 human prostate carcinoma The authors evaluated GLUT1 and GLUT12 expression in human prostate carcinoma cells. 12673735 Human
glut1 prostate carcinoma METHODS: Reverse transcription-polymerase chain reaction was performed on total RNA extracted from cultured prostate carcinoma cells LNCaP, C4, C4-2, and C4-2B using primers to amplify GLUT1, GLUT12, or the housekeeping gene, 36B4. 12673735 Human
glut1 human prostate carcinoma Sections of benign prostatic hyperplasia and human prostate carcinoma were stained for immunohistochemical detection of GLUT1 and GLUT12. 12673735 Human
glut1 benign prostatic hyperplasia Sections of benign prostatic hyperplasia and human prostate carcinoma were stained for immunohistochemical detection of GLUT1 and GLUT12. 12673735 Human
glut1 prostate carcinoma Immunofluorescence staining demonstrated both GLUT1 and GLUT12 on the plasma membrane and in the cytoplasm in all cultured prostate carcinoma cell lines, with GLUT1 but not GLUT12 appearing to colocalize with the Golgi. 12673735 Human
glut1 benign prostatic hyperplasia Immunohistochemical staining of benign prostatic hyperplasia indicated expression of GLUT1 but not GLUT12. 12673735 Human
glut1 human prostate carcinoma CONCLUSIONS: GLUT1 and GLUT12 are expressed in human prostate carcinoma cells. 12673735 Human
glut1 prostate carcinoma Further work will investigate the importance of glucose transport and GLUT1 and GLUT12 in prostate carcinoma cell growth. 12673735 Human
glut1 islet-cell tumors Northern blot analysis and reverse transcriptase-polymerase chain reaction revealed the presence of GLUT1 and GLUT3 mRNA in all human islet cell tumors and normal islets examined. 8421107 Human
glut1 transitional cell carcinomas MATERIALS AND METHODS: Thirty-one node- and distant metastasis-negative transitional cell carcinomas from patients with a five-year follow-up were evaluated for FAS and GLUT1 expression. 12680233 Human
glut1 malignant peripheral-nerve-sheath tumor (mpnst) To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 traumatic neuroma To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 perineurioma To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 schwannoma To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 neurofibroma To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 neuromas In normal nerves and neuromas, perineuriums were positive for Glut1 as well as for epithelial membrane antigen (EMA), and there were some CD34-positive fibroblast-like cells in the endoneurium. 12692193 Human
glut1 glial tumor The expression of GLUT1, a marker of cerebral endothelial differentiation, is a newly described property of glial tumor vessels that may have diagnostic and prognostic significance. 1739134 Human
glut1 malignant brain neoplasms In contrast, malignant brain neoplasms have relatively undifferentiated vessels that are highly permeable, proliferate to high vascular densities, and often lose GLUT1 expression. 1596083 Human
glut1 meningiomas More signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells, while the reverse was the case in all 6 meningiomas. 1617673 Human
glut1 astrocytoma More signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells, while the reverse was the case in all 6 meningiomas. 1617673 Human
glut1 actinic keratoses METHODS: A polyclonal anti-Glut1 antibody (MYM) and a standard ABC immunoperoxidase technique were used to determine Glut1 expression in invasive squamous cell carcinomas (SCCs), SCC in situ, basal cell carcinomas (BCCs), melanomas, actinic keratoses (AKs 9344196 Human
glut1 breast tumors RESULTS: Immunostaining showed that GLUT1 was significantly increased in hypoxic regions of the human colon and breast tumors. 16906425 Human
glut-1 primary colorectal cancer Clinicopathological Significance and Linkage of the Distribution of HIF-1alpha and GLUT-1 in Human Primary Colorectal Cancer. 17387384 Human
glut-1 primary tumors The presence of HIF-1alpha and GLUT-1 was visualized immunohistochemically in 123 primary tumors. 17387384 Human
glut-1 pyogenic granuloma The 19 cases histologically diagnosed as oral hemangioma that showed negative staining to GLUT-1 were reclassified as oral pyogenic granuloma or oral vascular malformations. 17241430 Human
glut-1 mucinous adenocarcinomas Non-mucinous adenocarcinomas expressed GLUT-1 and HIF-1alpha with significantly greater frequency than mucinous adenocarcinomas (p=0.002, p=0.0002, respectively). 17387384 Human
glut-1 pyogenic granulomas All sample cases with initial vascular malformation or pyogenic granulomas classification were negative to GLUT-1, demonstrating the accuracy of histological diagnosis of these lesions itself. 17241430 Human
glut-1 insulinoma In contrast, a beta cell line derived from an insulinoma arising in a transgenic mouse harboring an insulin-promoted simian virus 40 T-antigen oncogene (beta TC3) expressed very low levels of GLUT-2 but high levels of GLUT-1. 1729614 Mouse
glut-1 secondary tumors GLUT-1 expression in secondary tumors formed after injection of beta TC3 cells into mice was reduced. 1729614 Mouse
glut-1 secondary tumors Further, hyperplastic islets and primary and secondary tumors expressed low levels of GLUT-2 and no detectable GLUT-1 on the plasma membrane; these cells exhibited high basal insulin secretion and responded poorly to an increase in extracellular glucose. 1729614 Mouse
glut-1 human colon carcinoma The human colon carcinoma cell line Caco-2 was used as an enterocyte model to study the expression of the facilitative glucose transporters GLUT-1 and GLUT-2, and of the putative hexose transporter GLUT-5, which are expressed specifically in the gut. 1384349 Human
glut-1 pancreatic cancers Although overexpression of GLUT-1 glucose transporter has already been reported in human cancers, the mechanism of glucose entry into pancreatic cancers remains unknown. 9293783 Human
glut-1 benign tumors Three of six benign tumors showed strong GLUT-1 expression. 9293783 Human
glut-1 pancreatic tumor CONCLUSION: These data indicate that GLUT-1 has a significant role in the malignant glucose metabolism and may contribute to the increased uptake of FDG in PET imaging in patients with pancreatic tumor. 9293783 Human
glut-1 human pancreatic carcinoma We thus studied the expression of Glut-1 and glucose uptake, assessed with 2-fluorodeoxyglucose (FDG) and PET in human pancreatic carcinoma (PC) and chronic mass-forming pancreatitis (MFP). 9293784 Human
glut-1 pancreatic cancer CONCLUSION: The concomitant enhancement of glucose utilization and selective overexpression of Glut-1 mRNA in pancreatic cancer but not in MFP suggested constitutive activation of Glut-1 gene or decreased degradation of Glut-1 mRNA in human pancreatic can 9293784 Human
glut-1 human pancreatic cancer CONCLUSION: The concomitant enhancement of glucose utilization and selective overexpression of Glut-1 mRNA in pancreatic cancer but not in MFP suggested constitutive activation of Glut-1 gene or decreased degradation of Glut-1 mRNA in human pancreatic can 9293784 Human
glut-1 small-cell carcinomas In squamous cell carcinomas and small cell carcinomas, Glut-1 immunostaining was stronger in the central area of tumor cell nests corresponding to the hypoperfused region. 9619596 Human
glut-1 pancreatic tumors FDG uptake, GLUT-1 glucose transporter and cellularity in human pancreatic tumors. 9776278 Human
glut-1 pancreatic tumor CONCLUSION: These data indicate that GLUT-1 expression plays an essential role in higher FDG accumulation in pancreatic tumor FDG PET, and the cellularity has a significant influence on SUVs only in the condition of GLUT-1 strong positive expression. 9776278 Human
glut-1 epithelial ovarian carcinoma Immunoblotting and immunohistochemistry were used to assess the expression of Glut-1 hexose transport protein in the cell lines as well as in paraffin blocks from 28 surgical specimens of epithelial ovarian carcinoma. 10640972 Human
glut-1 epithelial ovarian carcinoma Immunoblotting and immunohistochemistry studies showed overexpression of Glut-1 in the cell lines and in 23 of 28 epithelial ovarian carcinoma specimens. 10640972 Human
glut-1 bladder transitional cell carcinoma We hypothesized that human erythrocyte glucose transporter (Glut-1) expression is increased in bladder transitional cell carcinoma (TCC) and that the grade of expression might correlate with the degree of malignancy. 10699635 Human
glut-1 papilloma METHODS: Immunostaining of Glut-1 protein was studied in normal bladder (5 cases), benign papilloma (10 cases), superficial tumor (48 cases), and invasive tumor (31 cases) tissue. 10699635 Human
glut-1 papilloma RESULTS: Immunostaining of Glut-1 protein was not expressed in the normal bladder or benign papilloma samples, but it was expressed in 63.0% (46 of 73) of the TCC samples. 10699635 Human
glut-1 bladder tumor In the superficial TCC samples, the bladder tumor recurrence rate did not significantly correlate with Glut-1 protein expression (P = 0.40). 10699635 Human
glut-1 embryonal neoplasms of the central nervous system Membranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous system. 10736070 Human
glut-1 embryonal neoplasms of the central nervous system We thus sought to determine whether GLUT-1 expression was limited to embryonal neoplasms of the central nervous system (CNS) which are presumably derived from developmentally arrested neuroectodermal stem cells. 10736070 Human
glut-1 pnet All embryonal tumours, MBs and PNET xenografts consistently showed GLUT-1 membrane staining. 10736070 Mouse
glut-1 supratentorial pnet Expression of GLUT-1 supports the stem cell nature of the cells of origin of MBs, supratentorial PNET and AT/RhTs. 10736070 Human
glut-1 cns neoplasms As a result, GLUT-1 is a useful marker to define the embryonal nature of CNS neoplasms. 10736070 Human
glut-1 borderline neoplasms Of the 21 borderline neoplasms, 20 (95.2%) were positive for GLUT-1. 11006027 Human
glut-1 pancreatic cancer Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression. 11039477 Human
glut-1 pancreatic cancer Five pancreatic cancer cell lines, CD11, CD18, HPAF, PANC-1, and MiaPaCa2 were used to investigate the effect of islet hormones on cell proliferation, glucose utilization, and GLUT-1 expression. 11039477 Human
glut-1 squamous carcinomas In epidermal carcinogenesis, HIF-1alpha, GLUT-1, PGK-1, and VEGF mRNAs were just detectable in early-stage hyperplasia, markedly increased in high-grade epidermal chest dysplasias, and further increased in invasive squamous carcinomas. 11085544 Human
glut-1 bronchioloalveolar carcinomas Of seven bronchioloalveolar carcinomas, six (85.7%) were negative for the expression of Glut-1, while only one (4.3%) of 23 non-bronchioloalveolar adenocarcinomas was negative (P < 0.0001). 11189940 Human
glut-1 bronchioloalveolar carcinomas Glut-1 expression, as well as [18F]FDG uptake, correlated with the degree of cell differentiation in adenocarcinomas, and both Glut-1 expression and [18F]FDG uptake were significantly lower in bronchioloalveolar carcinomas than in non-bronchioloalveolar c 11189940 Human
glut-1 colon cancer CONCLUSION: Gluts, especially Glut-1, are responsible for [18F]FDG uptake in a nude mouse model of colon cancer rather than hexokinase activity. 10025844 Mouse
glut-1 hyperplasia In all, these results indicate that the expression of GLUT-1 and GLUT-4 in heart during perinatal development is largely controlled at a transcriptional level by mechanisms that might be related to hyperplasia and that are independent from the signals tha 10364200 Rat
glut-1 human leukemia In the present study, antisense oligonucleotides and plasmid-derived antisense RNA against GLUT-1 gene were synthesized and transfected into human leukemia HL-60 cells to investigate the effect of these antisense nucleic acids on tumour growth. 10403494 Human
glut-1 thyroid carcinoma In 6 thyroid carcinoma patients, 131I uptake was studied in vivo; NIS expression was low in all samples; 3 patients with normal Glut-1 gene expression had 131I uptake in metastases, whereas the other 3 patients with increased Glut-1 gene expression had no 10487692 Human
glut-1 malignant thyroid tumors In conclusion, this study shows 1) a reduced expression of NIS gene in most hypofunctioning benign and malignant thyroid tumors; 2) a differential regulation of the expression of thyroid-specific genes; 3) an increased expression of Glut-1 gene in some ma 10487692 Human
glut-1 colorectal adenomas In colorectal adenomas and carcinomas, membranous expression of Glut-1 has been associated with higher grade of tumors and decreased survival time. 11351274 Human
glut-1 stage i nsclc METHODS: Over a 5 year period, all patients with a PET scan and clinical stage I NSCLC underwent an immunohistochemical analysis of their tumor for Glut-1 and Glut-3 expression. 11551404 Human
glut-1 ovarian carcinoma GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy. 11571727 Human
glut-1 ovarian carcinoma The objective of this study was to investigate the association of GLUT-1 with response to chemotherapy and outcome in patients with ovarian carcinoma. 11571727 Human
glut-1 melanoma Glucose is the primary energy source of tumours, including melanoma, and glucose transporter isoform 1 (Glut-1) and hexokinase are key rate-limiting factors in glucose metabolism. 11828256 Human
glut-1 melanoma The levels of Glut-1 and total hexokinase activity were measured in 31 melanoma biopsies to determine the extent of tumour-to-tumour variability in these parameters. 11828256 Human
glut-1 melanomas Thirty human melanomas exhibited a 22-fold variation in levels of Glut-1 and 29 exhibited a nine-fold variation in total cellular hexokinase activity. 11828256 Human
glut-1 melanoma The broad range in Glut-1 levels and hexokinase activity observed between melanomas suggests that these glycolytic rate-limiting parameters that influence the rate of glucose metabolism may contribute to the variability in melanoma response to treatment m 11828256 Human
glut-1 melanomas The broad range in Glut-1 levels and hexokinase activity observed between melanomas suggests that these glycolytic rate-limiting parameters that influence the rate of glucose metabolism may contribute to the variability in melanoma response to treatment m 11828256 Human
glut-1 liver tumors Diagnostic utility of Glut-1 and CA 15-3 in discriminating adenocarcinoma from hepatocellular carcinoma in liver tumors biopsied by fine-needle aspiration. 11836704 Human
glut-1 renal-cell carcinoma Significance of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of renal cell carcinoma and immunohistochemical glucose transporter 1 (GLUT-1) expression in the cancer. 11972644 Human
glut-1 renal-cell carcinoma The immunohistochemical examination of GLUT-1 in renal cell carcinoma produced different results in each patient. 11972644 Human
glut-1 cholangiocarcinoma Assessment of Glut-1 expression in cholangiocarcinoma, benign biliary lesions and hepatocellular carcinoma. 12066193 Human
glut-1 human rhabdomyosarcoma METHODS: We transiently transfected Glut-1 complementary DNA (cDNA) or Glut-1 antisense oligonucleotides in the human rhabdomyosarcoma cell line RD and analyzed MMP-2 mRNA expression and cell invasiveness. 12122099 Human
glut-1 stage i adenocarcinoma of the lung Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung. 12367793 Human
glut-1 stage i adenocarcinoma of the lung CONCLUSION: Glut-1 expression can be a predictor for prognosis in patients with resected stage I adenocarcinoma of the lung. 12367793 Human
glut-1 esophageal carcinomas RESULTS: Of the 95 esophageal carcinomas, 91 (95.8%) had some Glut-1 immunostaining in the membranes of the cancer cells. 12529975 Human
glut-1 esophageal cancer Comparison of Glut-1 expression and clinicopathological characteristics in the 95 patients with esophageal cancer revealed significant associations between Glut-1 expression and tumor status (p < 0.001), lymph node status (p < 0.05), metastatic status (p 12529975 Human
glut-1 carcinoma of the cervix GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding. 12532423 Human
glut-1 oral squamous-cell carcinoma Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. 12569601 Human
glut-1 head and neck carcinoma BACKGROUND: The overexpression of glucose transporters, especially of Glut-1, is a common characteristic of human malignancies, including head and neck carcinoma. 12569601 Human
glut-1 anaplastic carcinoma It has been previously shown that glucose transporter Glut-1 expression was detectable by immunostaining in tissue sections from anaplastic carcinoma, but not in normal thyroid tissue. 12667615 Human
glut-1 anaplastic carcinoma Using human thyroid anaplastic carcinoma cells, we studied the mechanism by which Glut-1 molecules are translocated from the endoplasmic reticulum to the cell surface. 12667615 Human
glut-1 anaplastic carcinoma These results show that O- and N-linked oligosaccharides arbored by Glut-1 are essential for glucose transport in anaplastic carcinoma cells. 12667615 Human
glut-1 malignant lymphoma We herein report a case of malignant lymphoma that showed differential FDG accumulation associated with the degree of glucose transporter 1 (GLUT-1) expression. 12932118 Human
glut-1 rectal carcinoma Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? 12942120 Human
glut-1 rectal carcinoma The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. 12942120 Human
glut-1 rectal carcinoma Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. 12942120 Human
glut-1 rectal tumours In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy. 12942120 Human
glut-1 breast tumors GLUT-1 and MMP-7 mRNA were also shown to be up-regulated in hypoxic macrophages in vitro by real-time RT-PCR, and these proteins were elevated in hypoxic macrophages in vitro and in hypoxic areas of human breast tumors. 14507633 Human
glut-1 oral cancer In conclusion, the results of this study indicate a relationship between Glut-1 expression and disease progression of oral cancer and could indicate a need for neoadjuvant chemoradiotherapy for those tumours demonstrating intense Glut-1 expression. 14962715 Human
glut-1 epithelial tumors of the ovary Expression of GLUT-1 glucose transfer, cellular proliferation activity and grade of tumor correlate with [F-18]-fluorodeoxyglucose uptake by positron emission tomography in epithelial tumors of the ovary. 15027127 Human
glut-1 astroglioma Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1). 15037634 Human
glut-1 astroglioma Based on these results, we postulate that syntaxin 1C regulates glucose transport in astroglioma cells by changing the intracellular trafficking of GLUT-1. 15037634 Human
glut-1 pancreatic cancer We tested the effects of modulating GLUT-1 expression on pancreatic cancer cellular invasiveness. 15349101 Human
glut-1 epithelioid hemangioma In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. 15469208 Human
glut-1 capillary hemangioma In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. 15469208 Human
glut-1 prostate adenocarcinoma Expression of glucose transporter 1 (Glut-1) in cell lines and clinical specimens from human prostate adenocarcinoma. 15517916 Human
glut-1 human prostate cancer To date, little is known about the role of Glut-1 in human prostate cancer (PC). 15517916 Human
glut-1 breast tumors RESULTS: Regional loss of ER-alpha expression occurs in breast tumors and is consistently present in hypoxic regions defined by the proximity of necrosis and induction of hypoxia-induced genes carbonic anhydrase IX (CA-IX) and glucose transporter 1 (Glut- 15623657 Human
glut-1 pancreatic tumor OBJECTIVES: To determine whether the differential growth inhibition of pancreatic tumor cells to the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) correlates with uptake, expression of GLUT-1 transporter, and levels of hypoxic-inducible factor-1alpha. 15714127 Human
glut-1 pancreatic tumors Moreover, if 2-DG shows clinical efficacy, it may be possible to predict which pancreatic tumors would be sensitive to this agent based on their GLUT-1 expression profile and their increased uptake of 2-fluoro-deoxy-D-glucose currently used to image tumor 15714127 Human
glut-1 arteriovenous malformations We studied a total of 50 specimens from patients with vascular anomalies, and found that GLUT-1 reactivity was positive in 18 out of 19 juvenile haemangiomas, negative in two out of two noninvoluting congenital haemangiomas (NICH) and negative in 29 out o 15780229 Human
glut-1 venous malformations We studied a total of 50 specimens from patients with vascular anomalies, and found that GLUT-1 reactivity was positive in 18 out of 19 juvenile haemangiomas, negative in two out of two noninvoluting congenital haemangiomas (NICH) and negative in 29 out o 15780229 Human
glut-1 urothelial papilloma We report our experience with glucose transporter-1 (Glut-1) expression in urothelial papilloma. 15812216 Human
glut-1 papilloma Glut-1 protein expression was studied in 32 cases of papilloma and 30 cases of carcinoma. 15812216 Human
glut-1 bladder papilloma No case of bladder papilloma expressed Glut-1 protein even in cases of recurrent papilloma. 15812216 Human
glut-1 papilloma No case of bladder papilloma expressed Glut-1 protein even in cases of recurrent papilloma. 15812216 Human
glut-1 urothelial carcinoma However, 67% of urothelial carcinoma specimens were stained for Glut-1 protein. 15812216 Human
glut-1 papilloma Conclusions: The study showed that papilloma does not express the Glut-1 protein in contrast to urothelial carcinoma. 15812216 Human
glut-1 urothelial carcinoma Conclusions: The study showed that papilloma does not express the Glut-1 protein in contrast to urothelial carcinoma. 15812216 Human
glut-1 urothelial papilloma This distinctive expression pattern of Glut-1 will possibly contribute to differentiate urothelial papilloma from low-grade urothelial carcinoma. 15812216 Human
glut-1 urothelial carcinoma This distinctive expression pattern of Glut-1 will possibly contribute to differentiate urothelial papilloma from low-grade urothelial carcinoma. 15812216 Human
glut1 gliomas We investigated the relationship of GLUT1 expression to other vascular characteristics in F98, 9L, and C6 gliomas and Walker 256 carcinomas implanted into adult rat brains. 1739134 Human
glut1 brain tumors In the present study, we have investigated the expression of both the erythrocyte-type (GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human brain tumors. 1617673 Human
glut1 glioblastomas "Tumor vessels" with endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered capillary endothelium expressed much GLUT1 mRNA. 1617673 Human
glut1 renal-cell tumours The characteristic over-expression of GLUT1 may be used as a diagnostic criterion for the discrimination between oncocytes and acidophilic (granular) cells in clear/acidophilic renal cell tumours which show a reduced expression of this glucose transporter 7921415 Human
glut1 benign epithelial tumors Using immunohistochemistry, we found that Glut1 is largely undetectable in normal epithelial tissues and benign epithelial tumors but is expressed in a significant proportion of a variety of human carcinomas. 8640778 Human
glut1 bcc The glucose transporter in freshly isolated and cultured BCC was identified as GLUT1 by Western immunoblots. 8908191 Human
glut1 thyroid nodules GLUT1 glucose transporter expression in benign and malignant thyroid nodules. 9226204 Human
glut1 stage i nsclc The aim of this study was to determine the biologic significance of Glut1 and Glut3 overexpression in Stage I NSCLC. 9305704 Human
glut1 stage i nsclc CONCLUSIONS: In Stage I NSCLC, Glut3 overexpression likely occurs after Glut1 overexpression. 9305704 Human
glut1 nsclc Glut1 and Glut3 are significant of poor prognosis indicators in cases of NSCLC. 9305704 Human
glut1 bcc Glut1 staining was present in the epidermis of 8 of 15 scars (53%) but was not detected in any BCC, even in areas of focal keratinization and squamous metaplasia. 9344196 Human
glut1 colon adenomas METHODS: GLUT1 glucose transporter immunostaining was studied in normal colon and benign colon adenomas and in 112 colorectal carcinomas from patients for whom long term clinical outcome was known. 9655290 Human
glut1 metastatic tumors The aim of this study was to investigate the gene expression levels of the GLUT family, especially GLUT1, GLUT3, and GLUT5 in primary lung cancer, metastatic liver tumors, and normal lung tissues, and to compare the expression levels of primary and metast 10622535 Human
glut1 angiosarcomas Focal GLUT1 immunoreactivity was found in 3 of 12 angiosarcomas, but not in any of 5 hemangioendotheliomas (epithelioid or infantile kaposiform). 10665907 Human
glut1 colorectal tumour Immunohistochemical detection of Glut1 protein was examined in 141 formalin-fixed and paraffin-embedded colorectal tumour specimens (57 adenomas, 84 carcinomas). 11166147 Human
glut1 transitional cell carcinoma of the urinary bladder Glut1 has been shown to be expressed in many human cancers, including transitional cell carcinoma of the urinary bladder (TCCB). 11299807 Human
glut1 vascular tumors DESIGN: In a retrospective study of a variety of vascular tumors and anomalies, we assessed lesional immunoreactivities for the placenta-associated vascular antigens FcgammaRII, Lewis Y antigen (LeY), merosin, and GLUT1. 11346333 Human
glut1 mucinous cystadenomas RESULTS: Benign serous and mucinous cystadenomas and endosalpingiosis were non-staining with GLUT1 antiserum. 11920478 Human
glut1 benign ovarian epithelial tumors GLUT1 staining is absent in benign ovarian epithelial tumors, and shows progressively more staining in invasive tumors as compared to borderline tumors. 11920478 Human
glut1 mpnst To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 cin 3 In CIN 3 high-risk HPV lesions, cervical cancer, and metastasis, GLUT1 was expressed at highest levels with a strong correlation of GLUT1 mRNA and protein expression. 14608894 Human
glut1 cervical tumor Cervical tumor cells respond to enhanced glucose utilization by up-regulation of GLUT1. 14608894 Human
glut1 cin 3 The strong induction of GLUT1 mRNA and protein in HPV-positive CIN 3 lesions suggests GLUT1 overexpression as an early event in cervical neoplasia. 14608894 Human
glut1 metastatic tumors The Glut1 expression of metastatic tumors was higher in true-positive nodes than that in false-negative nodes (P < 0.001). 15181136 Human
glut1 metastatic squamous cell carcinomas Metastatic squamous cell carcinomas showed stronger Glut1 expression than adenocarcinomas and no false-negative results on (18)F-FDG PET. 15181136 Human
glut1 metastatic adenocarcinomas On the other hand, metastatic adenocarcinomas exhibited focal and weak Glut1 expression with frequent false-negative results. 15181136 Human
glut1 invasive carcinomas RESULTS: All of the invasive carcinomas were positive for GLUT1. 15331928 Human
glut1 benign ovarian neoplasms In contrast, GLUT1 expression was moderate in borderline tumors and weak to negative in all benign ovarian neoplasms. 15331928 Human
glut1 borderline tumors In contrast, GLUT1 expression was moderate in borderline tumors and weak to negative in all benign ovarian neoplasms. 15331928 Human
glut1 ovarian cancer High GLUT1 mRNA levels were observed only in ovarian cancer. 15331928 Human
glut1 malignant ovarian neoplasms The intensity of GLUT1 expression in malignant ovarian neoplasms was associated neither with tumor characteristics nor with patient survival. 15331928 Human
glut1 ovarian cancer The close relationship between GLUT1 mRNA and protein expression points towards the potential relevance of GLUT1 as a diagnostic tool and therapeutic target in ovarian cancer. 15331928 Human
glut1 endometrial cancer This regulation mirrors the role played by estrogen and progesterone on the incidence of cancer in this tissue and suggests that GLUT1 may be utilized by endometrial cancer cells to fuel their demand for increased energy requirement. 15350188 Human
glut1 bile duct carcinoma CONCLUSIONS: These results indicate that GLUT1 might be related to development of bile duct carcinoma and its expression was a more reliable marker for detection of bile duct carcinoma than CK19. 15362741 Human
glut1 intraneural perineurioma The current study suggests that Glut1 is a useful marker of intraneural perineurioma. 15086844 Human
glut1 cancer Here, we show that glucose deprivation leads to a significant increase in the mRNA level of VEGF, GLUT1, and PFKFB3 genes in several cancer cells via a hypoxia-inducible factor-1-independent mechanism, and we demonstrate an essential role of AMPK in these 15640157 Human
glut1 ovarian carcinomas Immunohistochemical detection of glucose transporter GLUT1 in benign and malignant fallopian tube epithelia, with comparison to ovarian carcinomas. 15859637 Human
glut1 serous carcinomas OBJECTIVE: We present an immunohistochemical survey of GLUT1 expression in benign and malignant fallopian tube epithelia, and compare serous carcinomas of the fallopian tube and ovary. 15859637 Human
glut1 fallopian tube cancers On average, GLUT1 staining in primary fallopian tube cancers was less extensive than in primary ovarian adenocarcinomas. 15859637 Human
glut1 ovarian adenocarcinomas On average, GLUT1 staining in primary fallopian tube cancers was less extensive than in primary ovarian adenocarcinomas. 15859637 Human
glut1 fallopian tube adenocarcinomas CONCLUSIONS: GLUT1 immunostaining of fallopian tube adenocarcinomas was substantially stronger and more extensive than staining of benign tubal epithelium, consistent with previously described findings in carcinomas versus benign tissues from many primary 15859637 Human
glut1 ovarian serous adenocarcinomas The difference in extent of GLUT1 staining between primary tubal and primary ovarian serous adenocarcinomas is discussed. 15859637 Human
glut1 vascular tumors The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children. 15937818 Human
glut1 vascular skin tumors Immunostaining for GLUT1 is becoming valuable for predicting the outcome of vascular skin tumors. 15937818 Human
glut1 colorectal adenocarcinoma METHODS: Immunohistochemistry was used to detect expressions of Glut1, HIF-1alpha, and proliferating cell nuclear antigen (PCNA) in 60 specimens of colorectal adenocarcinoma and 20 specimens of normal colorectal tissues. 15946479 Human
glut1 esophageal carcinomas The aim of this study is to evaluate the prognostic utility of Glut1 expression in esophageal carcinomas. 16045581 Human
glut1 colorectal adenocarcinoma Glucose transporter GLUT1 in colorectal adenocarcinoma cell lines is inversely correlated with tumour cell proliferation. 16101160 Human
glut 1 islet-cell tumors The islet cell tumors from all five patients contained Glut 1, a low-Km glucose transporter protein, which is not normally present in beta-cells. 8017722 Human
glut 1 ehrlich ascites carcinoma The treatment of doxorubicin nor caffeine, and any treatment schedule did not change the amount and appearance of GLUT 1 as glucose transporter on Ehrlich ascites carcinoma cell. 11766989 Mouse
glut 1 insulinomas Insulinomas were surgically removed from all patients and Glut 1 and Glut 2 transporter proteins were measured in solubilized tumor membranes by immune blotting. 8017722 Human
glut 1 adenomas In three of seven adenomas and 10 of 12 carcinomas, expression of GLUT 1 was increased compared with normal liver parenchyma. 8364915 Rat
glut 1 adenomas Reexpression of GLUT 1, however, appears in a few MCF and in the majority of adenomas and carcinomas. 8364915 Rat
glut 1 melanoma Comparative studies among the four melanoma cell lines demonstrated that the lowest FDG uptake in SK-MEL 24 corresponded strongly to the data for DT (population doubling time) and MTT (tetrazolium salt) cell viability as well as hexokinase (HK) activity, 16043894 Human
glut 1 invasive cancer There was a correlation between intensity of reaction for GLUT 1 and histologic grade of tumor (P = 0.0027) and with progression from normal or dysplastic lesions to invasive cancer (P = 0.0001). 12144819 Human
glut 1 hypopharyngeal carcinoma We hypothesized that a hypopharyngeal carcinoma, characterized by high frequency of lymph node spread or distant metastasis, was associated with glucose transporter 1 (Glut 1) overexpression. 12552944 Human
glut 1 head and neck squamous cell carcinoma The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy +/- chemotherapy. 15847702 Human
glut1 islet cell tumors Northern blot analysis and reverse transcriptase-polymerase chain reaction revealed the presence of GLUT1 and GLUT3 mRNA in all human islet cell tumors and normal islets examined. 8421107 Human
glut astrocytic tumors The expression of facilitative glucose transporter (GLUT) isoforms in human astrocytic tumors was examined. 8245960 Human
glut 1 squamous cell carcinomas of the head and neck In squamous cell carcinomas of the head and neck (HNSCC) and metastases, GLUT 1 was always expressed strongly. 9935199 Human
glut 1 transitional cell carcinoma of the urinary bladder Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival. 11299807 Human
glut-i pancreatic cancer Furthermore, after 24-hour treatment with insulin, GLUT-I expression in pancreatic cancer cells was markedly increased, indicating that insulin enhances glucose utilization partly through increasing glucose transport. 11039477 Human
glut1 renal cell carcinoma The localization of 2 isoforms of glucose transporters (GLUT1 and GLUT4) in 75 patients with renal cell carcinoma was examined immunohistochemically. 7861542 Human
glut1 basal cell carcinomas (bccs) METHODS: A polyclonal anti-Glut1 antibody (MYM) and a standard ABC immunoperoxidase technique were used to determine Glut1 expression in invasive squamous cell carcinomas (SCCs), SCC in situ, basal cell carcinomas (BCCs), melanomas, actinic keratoses (AKs 9344196 Human
glut1 renal carcinoma In contrast pVHL19, in biochemical fractionation experiments, is equally distributed between the nucleus and cytosol and is not found in association with membranes. pVHL19, like pVHL30, can bind to elongin B, elongin C, and Hs-Cul2 in coimmunoprecipitatio 9751722 Human
glut1 signet ring cell carcinoma Signet ring cell carcinoma and mucinous adenocarcinoma rarely were positive (2.0% and 6.3%, respectively) and papillary adenocarcinoma (44%) showed slightly higher positivity for Glut1 than tubular (32%) or poorly differentiated adenocarcinoma (28%). 11505409 Human
glut1 malignant peripheral nerve sheath tumor (mpnst) To clarify the cellular composition of various peripheral nerve tumorous lesions (traumatic neuroma, 5 cases; schwannoma, 10 cases; neurofibroma, 14 cases; perineurioma, 3 cases; conventional malignant peripheral nerve sheath tumor (MPNST), 7 cases; perin 12692193 Human
glut1 endometrial hyperplasia [Expression of glucose transporter-1 in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma] OBJECTIVE: To investigate the expression of glucose transporter-1 (GLUT1) in endometrial hyperplasia and well-differentiated endometrioid 12940086 Human
glut1 endometrioid adenocarcinoma [Expression of glucose transporter-1 in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma] OBJECTIVE: To investigate the expression of glucose transporter-1 (GLUT1) in endometrial hyperplasia and well-differentiated endometrioid 12940086 Human
glut1 endometrioid adenocarcinomas [Expression of glucose transporter-1 in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma] OBJECTIVE: To investigate the expression of glucose transporter-1 (GLUT1) in endometrial hyperplasia and well-differentiated endometrioid 12940086 Human
glut1 atypical hyperplasia CONCLUSIONS: Overexpression of GLUT1 is a consistent feature of atypical hyperplasia and adenocarcinoma. 12940086 Human
glut1 metastatic renal cell carcinoma GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. 14606586 Human
glut1 metastatic tumors CONCLUSION: The results of this study indicate that (a). lymphoid follicular hyperplasia with Glut1 overexpression may have a causal relationship with high (18)F-FDG uptake of false-positive nodes and (b). the lower expression of Glut1 in metastatic tumor 15181136 Human
glut1 lung adenocarcinoma [Relationship between overexpression of facilitative glucose transporter-1 and fluorodeoxyglucose uptake in primary human lung adenocarcinoma] OBJECTIVE: To assess the relationship between the overexpression of facilitative glucose transporter-1 (Glut1) a 15363231 Human
glut1 lung adenocarcinoma CONCLUSION: Glut1 overexpression is universal in the lung adenocarcinoma and correlate with FDG uptake. 15363231 Human
glut1 ovarian neoplasm [Expression of glucose transporter-1 and its correlation with basic fibroblast growth factor and proliferating cell nuclear antigen in epithelial ovarian neoplasm] OBJECTIVE: To study the expression of glucose transporter-1 (GLUT1) and its correlation wit 15924676 Human
glut1 benign epithelial tumors METHODS: Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 cases of benign epithelial tumors, seven cases of borderline tumor and 44 cases of epithelial o 15924676 Human
glut1 epithelial ovarian carcinoma METHODS: Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 cases of benign epithelial tumors, seven cases of borderline tumor and 44 cases of epithelial o 15924676 Human
glut1 benign ovarian tumor RESULTS: In normal ovary and benign ovarian tumor, GLUT1 was not detected, but in borderline ovarian tumor and cancer, the positive expression ratio of GLUT1 was 6/7 and 91% (40/44), respectively. 15924676 Human
glut1 borderline tumors The intensity of GLUT1 in ovarian epithelial neoplasm was significantly higher than in borderline tumors. 15924676 Human
glut1 ovarian epithelial neoplasm The intensity of GLUT1 in ovarian epithelial neoplasm was significantly higher than in borderline tumors. 15924676 Human
glut1 ovarian epithelial tumors CONCLUSIONS: (1) The expression of GLUT1 may be closely related to malignant transformation of ovarian epithelial tumors. 15924676 Human
glut1 colorectal adenocarcinoma This study was to investigate the expressions of Glut1 and HIF-1alpha in colorectal adenocarcinoma, and explore their correlations to cell proliferation. 15946479 Human
glut1 colorectal adenocarcinoma RESULTS: Positive rates of Glut1 and HIF-1alpha were significantly higher in colorectal adenocarcinoma tissues than in normal colorectal tissues (58.3% vs. 0, P < 0.01; 73.3% vs. 0, P < 0.01). 15946479 Human
glut1 colorectal adenocarcinoma CONCLUSIONS: The overexpressions of Glut1 and HIF-1alpha play important roles in carcinogenesis and progression of colorectal adenocarcinoma, and closely correlate with cell proliferation of colorectal adenocarcinoma. 15946479 Human
glut murine erythroleukaemia The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. 9010020 Human
glut prostate tumors The normalized amounts of GLUT and Hk mRNA were lower in spontaneous fibroadenomas and prostate tumors than in chemically induced mammary. 9234332 Rat
glut benign tumors To evaluate the relationship between GLUT glucose transporters and FDG uptake, FDG-PET was performed in 34 preoperative patients (mean age, 60.9 yr) with suspected pancreatic tumors, including 28 malignant and 6 benign tumors. 9293783 Human
glut pancreatic tumors To evaluate the relationship between GLUT glucose transporters and FDG uptake, FDG-PET was performed in 34 preoperative patients (mean age, 60.9 yr) with suspected pancreatic tumors, including 28 malignant and 6 benign tumors. 9293783 Human
glut retinoblastoma We investigated the expression of glucose transporter (GLUT) protein isoforms in two human retinoblastoma cell lines, Y79 and WERI-Rb1, by Western blotting analysis with anti-GLUT1, 2, 3, and 4 antibodies. 9304435 Human
glut retinoblastoma Our findings are of interest because (1) the expression of GLUT protein isoforms in the two retinoblastoma cell lines was different, and (2) GLUT4 protein, the insulin-sensitive GLUT isoform, was detected in Y79. 9304435 Human
glut human breast cancer If this relationship is found to exist in a larger number of human breast cancer tissues, it may be possible to develop diagnostic and therapeutic strategies based on targeted GLUT isoform expression. 9654596 Human
glut gastrointestinal cancer The roles of tumor necrosis factor (TNF)-alpha and the facilitative glucose transporter (GLUT) 4 on the induction of insulin resistance in peripheral tissues of cancer patients was examined by quantitative competitive PCR on biopsies of abdominal rectal m 9918825 Human
glut gastric tumor METHODOLOGY: The presence of mRNA for 5 facilitative glucose transporter (GLUT) isoforms was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in paired samples of normal gastric mucosa and gastric tumor from 20 individuals. 10522065 Human
glut liver metastases Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. 10622535 Human
glut metastatic liver tumors The aim of this study was to investigate the gene expression levels of the GLUT family, especially GLUT1, GLUT3, and GLUT5 in primary lung cancer, metastatic liver tumors, and normal lung tissues, and to compare the expression levels of primary and metast 10622535 Human
glut metastatic tumors The aim of this study was to investigate the gene expression levels of the GLUT family, especially GLUT1, GLUT3, and GLUT5 in primary lung cancer, metastatic liver tumors, and normal lung tissues, and to compare the expression levels of primary and metast 10622535 Human
glut metastatic liver tumors Our results show that the gene expression pattern of the GLUT family is different between primary and metastatic liver tumors and suggest that the energy transporters in metastatic tumors may be different from those in primary tumors. 10622535 Human
glut metastatic tumors Our results show that the gene expression pattern of the GLUT family is different between primary and metastatic liver tumors and suggest that the energy transporters in metastatic tumors may be different from those in primary tumors. 10622535 Human
glut colon adenocarcinoma The expression of facilitative glucose transporter isoforms in colon adenocarcinoma and the possible role of k-ras in inducing GLUT (glucose transporter) mRNA were studied. 10806301 Human
glut ovarian cancer The aim of the present study was to analyze the expression of different GLUT isoforms (GLUT1-4) and to investigate whether alterations in their expression pattern accompany the malignant transformation and progression of ovarian cancer. 15331928 Human
glut endometrial cancer These data demonstrate that different hormonal treatments differentially regulate GLUT expression and glucose transport in this endometrial cancer cell line. 15350188 Human
glut-1 small cell carcinomas In squamous cell carcinomas and small cell carcinomas, Glut-1 immunostaining was stronger in the central area of tumor cell nests corresponding to the hypoperfused region. 9619596 Human
glut-1 granuloma annulare (ga) METHODS: A polyclonal anti-Glut-1 antibody was used with a standard immunoperoxidase technique to determine Glut-1 expression by fibroblasts in areas of sclerotic collagen from specimens taken from diabetic individuals with necrobiosis lipoidica,and non-d 11401674 Human
glut-1 ovarian carcinoma CONCLUSIONS: GLUT-1 status is an independent prognostic factor of response to chemotherapy in advanced stage ovarian carcinoma. 11571727 Human
glut-1 ovarian carcinoma These results suggest that the assessment of GLUT-1 status may provide clinically useful prognostic information in patients with ovarian carcinoma. 11571727 Human
glut-1 renal cell carcinoma Significance of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of renal cell carcinoma and immunohistochemical glucose transporter 1 (GLUT-1) expression in the cancer. 11972644 Human
glut-1 renal cell carcinoma The immunohistochemical examination of GLUT-1 in renal cell carcinoma produced different results in each patient. 11972644 Human
glut-1 cervical intraepithelial neoplasia (cin) Twenty normal cervical and 20 cervical intraepithelial neoplasia (CIN) sets of tissue were also used to compare the results of Glut-1 expression in these tissues. 14734665 Human
glut-1 cin None or only minimal expression of Glut-1 was observed in basal layers of normal and CIN tissues. 14734665 Human
glut-1 lobular capillary hemangioma (lch) In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. 15469208 Human
glut-1 invasive carcinomas Regional decrease of ER-alpha expression was consistently observed in peri-necrotic regions as compared to distant regions in both in-situ carcinomas (n=29, P <0.0001) and invasive carcinomas (n=20, P=0.0001), which was closely associated with the inducti 15777504 Human
glut-1 ovarian epithelial tumors OBJECTIVE: To investigate the reported increase in the expression of the glucose transporter GLUT-1 in borderline and malignant ovarian epithelial tumors and its relationship to prognosis. 16220828 Human
glut-1 ovarian epithelial tumors STUDY DESIGN: In this study, areas in which immunohistochemical membranous staining with GLUT-1 were most evident were selected, and the proportions of GLUT-1 expression in 46 benign, 11 borderline and 42 malignant cases of ovarian epithelial tumors were 16220828 Human
glut-1 borderline tumors RESULTS: GLUT-1 expression was determined in all borderline tumors (11 of 11) and in 97.6% of malignant tumors (41 of 42). 16220828 Human
glut-1 benign tumors No GLUT-1 expression was observed in benign tumors. 16220828 Human
glut-1 borderline tumors The intensity of GLUT-1 staining was lower in borderline tumors than in malignant cases. 16220828 Human
glut-1 ovarian epithelial tumors CONCLUSION: When GLUT-1 expression in borderline and malignant ovarian epithelial tumors was analyzed against prognosis, no statistically significant difference was identified. 16220828 Human
glut-1 chondroblastoma These findings suggest that Glut-1 and HK-II expression are not strongly related to FDG uptake in chondroblastoma. 16333655 Human
glut-1 soft tissue sarcomas Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography. 16506050 Human
glut-1 atypical endometrial hyperplasia GLUT-1 is preferentially expressed in atypical endometrial hyperplasia and endometrial adenocarcinoma. 16785788 Human
glut-1 endometrial adenocarcinoma GLUT-1 is preferentially expressed in atypical endometrial hyperplasia and endometrial adenocarcinoma. 16785788 Human
glut-1 endometrial polyps The authors examined the IHC expression of GLUT-1 in cases of proliferative endometrium (n=12), secretory endometrium (n=10), endometrial polyps (n=10), adenomyosis (n=18), simple hyperplasia (n=14), complex hyperplasia without atypia (n=17), complex hype 16785788 Human
glut-1 endometrial polyps All cases from proliferative endometrium, secretory endometrium, adenomyosis, and simple hyperplasia and 90% (9/10 cases) of the endometrial polyps were negative for GLUT-1. 16785788 Human
glut-1 endometrial tumors These data suggest that the expression of GLUT-1 transporter may be closely related to the malignant transformation of epithelial endometrial tumors by supporting their increased need for glucose metabolism. 16785788 Human
glut-1 head and neck squamous cell carcinoma Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1. 16916559 Human
glut 1 islet cell tumors The islet cell tumors from all five patients contained Glut 1, a low-Km glucose transporter protein, which is not normally present in beta-cells. 8017722 Human
slc2a1 endometrial carcinomas The expression levels of DEC2, CA9, and SLC2A1 were significantly higher in the 4 atypical hyperplasia tissues and 82 endometrial carcinomas compared with those in the 21 normal endometria. 17342330 Human
slc2a1 atypical hyperplasia The expression levels of DEC2, CA9, and SLC2A1 were significantly higher in the 4 atypical hyperplasia tissues and 82 endometrial carcinomas compared with those in the 21 normal endometria. 17342330 Human
glut-1 benign tumors GLUT-1 is largely undetectable by immunohistochemistry in normal epithelial tissues and benign tumors, but is expressed in a variety of malignancies. 17192790 Human
glut-1 pyogenic granuloma AIM: To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to ob 17241430 Human
glut-1 pyogenic granulomas MATERIALS AND METHODS: Immunohistochemistry for GLUT-1 was performed in 93 histologically diagnosed cases of oral benign vascular lesions: 17 vascular malformations, 19 hemangiomas, nine varix, and 48 pyogenic granulomas. 17241430 Human
glut-1 rms As GLUT-1 was induced via Hif-1alpha under hypoxia in A204 RMS and A673 ES, these findings suggest that the Hif-1alpha-mediated increase in glucose uptake plays an important role in conferring apoptosis resistance. 17043658 Human
glut-1 large cell carcinomas CONCLUSION: The present study supports the hypothesis that tumor cell differentiation in combination with overexpression of GLUT-1 and GLUT-3 determine the extent of FDG accumulation and that squamous cell carcinomas accumulate more FDG than adenocarcinom 17046099 Human
glut-1 malignant mesothelioma Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. 17192790 Human
glut1 renal cell tumours The characteristic over-expression of GLUT1 may be used as a diagnostic criterion for the discrimination between oncocytes and acidophilic (granular) cells in clear/acidophilic renal cell tumours which show a reduced expression of this glucose transporter 7921415 Human
glut1 nonsmall cell lung carcinoma Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. 9305704 Human
glut1 lymph node metastases It is concluded that (a) Glut1 is expressed as a late event in the carcinogenesis process in human colorectal cancer, and (b) expression of Glut1 in a high proportion of cancer cells is associated with a high incidence of lymph node metastases. 9816281 Human
glut1 lymph node metastasis GLUT1 expression in adenocarcinoma of the lung is correlated with reduced cell differentiation, larger tumor size and positive lymph node metastasis. 10425560 Human
glut1 lymph node metastasis The incidence of Glut1 expression at the deepest invasive site correlated significantly with histologic grade (W/Mw grade, 28% vs. Mp/Por/Muc grade, 48%), depth of invasion (invasion of muscularis propria/invasion of subserosa or subadventitia, 29% vs. in 11244332 Human
glut1 lymph node metastasis Multivariate analysis with logistic regression for 5-year survival in patients who had undergone curative surgery showed that lymph node metastasis and Glut1 expression were significant risk factors. 11244332 Human
glut1 lymph node metastasis Glut1 positivity was associated with depth of invasion (P = 0.0001), lymphatic permeation (P = 0.0001), venous invasion (P = 0.0001), lymph node metastasis (P = 0.0001), hepatic metastasis (P = 0.0001), and carcinoma stage (P = 0.0001). 11505409 Human
glut1 rat choriocarcinoma We show here that the level of GLUT1 protein in rat choriocarcinoma cells (Rcho-1) decreased during differentiation. 11689000 Rat
glut1 lung squamous cell carcinoma [Preliminary research of the relationship between overexpression of facilitative glucose transporter-1 and fluorodeoxyglucose uptake in primary human lung squamous cell carcinoma] OBJECTIVE: To assess the relationship between the overexpression of facilit 14728832 Human
glut1 lung squamous cell carcinoma CONCLUSIONS: (1) Glut1 overexpression is universal in the lung squamous cell carcinoma. 14728832 Human
glut1 lung squamous cell carcinoma (3) Glut1 expression and FDG uptake and tumor size appear to be correlated with each other in patients with lung squamous cell carcinoma. 14728832 Human
glut1 ovarian borderline tumors GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. 15331928 Human
glut1 primary ovarian cancer CONCLUSIONS: GLUT1 mRNA and protein were found to be expressed specifically in primary ovarian cancer. 15331928 Human
glut1 liver carcinomas Diagnostic utility of GLUT1 in the differential diagnosis of liver carcinomas. 15362741 Human
glut1 borderline tumor METHODS: Streptavidin-peroxidase complex technique was used to examine the expression of GLUT1, bFGF and PCNA protein in six cases of normal ovarian tissue, 20 cases of benign epithelial tumors, seven cases of borderline tumor and 44 cases of epithelial o 15924676 Human
glut1 borderline ovarian tumor RESULTS: In normal ovary and benign ovarian tumor, GLUT1 was not detected, but in borderline ovarian tumor and cancer, the positive expression ratio of GLUT1 was 6/7 and 91% (40/44), respectively. 15924676 Human
glut1 lymph node metastasis The staining intensity of GLUT1 was significantly correlated with the histological grade of the tumor (r(S) = 0.499, P = 0.001), and was positively correlated with the clinical stage, cancer invasion and lymph node metastasis. 15924676 Human
glut1 lymph node metastasis Glut1 and HIF-1alpha levels were positively correlated with PCNA level (r(1)=0.409, P < 0.01; r(2)=0.323, P < 0.05), and were associated with Dukes' stage and lymph node metastasis. 15946479 Human
glut ductal breast cancer Invasiveness of the human breast cancer lines MCF-7, MDA-MB-435 and MDA-MB-231 was measured using an in vitro assay and compared with cellular GLUT isoform expression, assessed by Western blot analysis and verified by immunohistochemistry in a poorly diff 9654596 Human
glut-1 rat mammary cancer (rmc) To assess the relationship between cellular glucose transporter Glut-1 (brain/erythrocyte) and FDG uptake in malignant tumors we studied the expression of Glut-1 and 3H-FDG uptake in a syngeneic rat mammary cancer (RMC), an animal tumor model that closely 8683298 Human
glut-1 ductal breast cancer In a poorly differentiated human ductal breast cancer, in situ GLUT-1 staining was intense. 9654596 Human
glut-1 borderline tumor Our findings show a progressive increase in the expression of the GLUT-1 transporter from the borderline tumor to the high-grade carcinomas. 11006027 Human
glut-1 primary ovarian carcinomas METHODS: Histologic sections of formalin fixed, paraffin embedded specimens from 113 primary ovarian carcinomas were stained for GLUT-1 by using polyclonal GLUT-1 antibody (Dako Co., Carpinteria, CA) and the labeled streptavidin biotin procedure. 11571727 Human
glut-1 oral squamous cell carcinoma Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. 12569601 Human
glut-1 diffuse lymphoma On the other hand, a bone marrow specimen with diffuse lymphoma cell involvement indicated showed no FDG accumulation and also revealed a negative GLUT-1 expression. 12932118 Human
glut1 liver metastases Purpose: To investigate hypoxia measured by pimonidazole binding, glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CA-IX) expression, proliferation, and vascularity in liver metastases of colorectal cancer and to compare GLUT1 and CA-IX expression 16242253 Human
glut1 liver metastases Thirteen paraffin-embedded primary tumors were stained immunohistochemically for GLUT1 and CA-IX expression, which was analyzed semiquantitatively in primary tumors and corresponding liver metastases. 16242253 Human
glut1 esophageal squamous cell carcinoma Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. 16391802 Human
glut1 breast tumor Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. 16523487 Human
glut1 intraepithelial neoplasia Immunohistochemical detection of GLUT1, p63 and phosphorylated histone H1 in head and neck squamous intraepithelial neoplasia: evidence for aberrations in hypoxia-related, cell cycle- and stem-cell-regulatory pathways. 16681687 Human
glut1 intraepithelial neoplasia In hyperplasia phospho-histone H1+ cells were also limited to the parabasal layer; p63 positivity was essentially identical to that in normal epithelium; GLUT1 characteristically stained basal cells in rete-like areas. p63 staining in squamous intraepithe 16681687 Human
glut1 intraepithelial neoplasia Squamous intraepithelial neoplasia (grade 1) was readily distinguishable from normal epithelium with both phospho-histone H1 and GLUT1 immunostaining; both markers were detected in cell layers above the parabasal layer. 16681687 Human
glut1 grade 3 squamous intraepithelial neoplasia Squamous metaplasia and grade 3 squamous intraepithelial neoplasia were not distinguishable with p63 (both showed full-thickness staining) but were readily distinguishable with GLUT1 and phospho-histone H1 stains. 16681687 Human
glut1 metaplasia Squamous metaplasia and grade 3 squamous intraepithelial neoplasia were not distinguishable with p63 (both showed full-thickness staining) but were readily distinguishable with GLUT1 and phospho-histone H1 stains. 16681687 Human
glut1 intraepithelial neoplasia GLUT1 appeared to be the most sensitive marker for all grades of intraepithelial neoplasia. 16681687 Human
glut1 invasive carcinoma Intraepithelial components also displayed basal and 'antibasal' GLUT1 staining patterns, homologous to the pro- and antistromal patterns in invasive carcinoma; basal patterns in intraepithelial lesions appeared to be more predictive of keratiniz 16681688 Human
glut1 invasive carcinoma GLUT1 expression patterns in intraepithelial lesions may be predictive of the differentiation status of the associated invasive carcinoma. 16681688 Human
glut1 infantile hemangioma Microscopic features, such as thick vascular walls, multilamellated basement membrane, relatively uniform channel size, and GLUT1 immunopositivity are reminiscent of infantile hemangioma, particularly in its involutive phase. 16780464 Human
glut1 serous neoplasms CONCLUSIONS: GLUT1 is expressed in the vast majority of USPC and EIC, suggesting a biological role during the early steps of carcinogenesis in endometrial serous neoplasms. 16842248 Human
glut-1 atypical meningiomas Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas but atypical meningiomas stained more intensely than benign meningiomas. 16142342 Human
glut-1 benign meningiomas Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas but atypical meningiomas stained more intensely than benign meningiomas. 16142342 Human
glut-1 meningiomas Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas but atypical meningiomas stained more intensely than benign meningiomas. 16142342 Human
glut-1 hemangiomas [The impact of Glut-1 marker application on the diagnosis and treatment of congenital vascular anomalies] Hemangiomas of infancy have a unique vascular phenotype demonstrated by glucose transporter 1 (GLUT-1) staining marker. 16209371 Human
glut-1 follicular adenoma Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular adenoma, and 22 c 16273245 Human
glut-1 follicular carcinoma (fc) Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular adenoma, and 22 c 16273245 Human
glut-1 papillary carcinoma (pc) Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular adenoma, and 22 c 16273245 Human
glut-1 follicular adenomas GLUT-1 expression was observed in 5% (3/60) of FC cases, but all follicular adenomas and adenomatous goitres were negative for GLUT-1 (PC vs. 16273245 Human
glut-1 follicular adenomas Semi-quantitative analysis of glut-1 mRNA by RT-PCR showed a tendency toward higher expression in PCs compared to FCs, follicular adenomas and adenomatous goitres, and the mRNA expression in PCs with a membrane-like pattern was higher than those showing c 16273245 Human
glut-1 epithelioid sarcoma METHODS AND RESULTS: Nine cases of epithelioid sarcoma and five cases of meningioma were studied in an immunohistochemical analysis of 'perineurial' antigens [GLUT-1, claudin-1, epithelial membrane antigen (EMA) and VE-cadherin] and of 'end 16324194 Human
glut-1 meningioma METHODS AND RESULTS: Nine cases of epithelioid sarcoma and five cases of meningioma were studied in an immunohistochemical analysis of 'perineurial' antigens [GLUT-1, claudin-1, epithelial membrane antigen (EMA) and VE-cadherin] and of 'end 16324194 Human
glut-1 epithelioid sarcoma Both epithelioid sarcoma and meningioma showed frequent expression of the perineurial markers GLUT-1, claudin-1 and EMA. 16324194 Human
glut-1 meningioma Both epithelioid sarcoma and meningioma showed frequent expression of the perineurial markers GLUT-1, claudin-1 and EMA. 16324194 Human
glut-1 bcc METHODS: Immunohistochemical staining for GLUT-1 was performed on paraffin-embedded cell blocks of 28 cases with the following cytologic diagnoses: 1) metastatic SCC (11 cases); 2) atypical squamous cells, SCC [corrected] cannot be excluded (6 cases); and 16435376 Human
glut-1 cyst METHODS: Immunohistochemical staining for GLUT-1 was performed on paraffin-embedded cell blocks of 28 cases with the following cytologic diagnoses: 1) metastatic SCC (11 cases); 2) atypical squamous cells, SCC [corrected] cannot be excluded (6 cases); and 16435376 Human
glut-1 bcc The squamous cells in all 11 cases with cytologic findings consistent with BCC were negative for GLUT-1; tissue follow-up confirmed diagnoses of BCC in 8 cases. 16435376 Human
glut-1 bcc Subsequent excisional biopsies in these cases revealed 4 cases of metastatic SCC (3 positive and 1 negative for GLUT-1), 1 case of BCC (negative for GLUT-1), and 1 case of thyroglossal duct cyst (negative for GLUT-1). 16435376 Human
glut-1 breast adenocarcinoma METHODS: We evaluated, in vitro, the messenger RNA (mRNA) and protein levels of Glut-1 and HKII in MCF-7, a breast adenocarcinoma cell line, and (3)H-FDG uptake, both in untreated conditions and during treatment with either DOX or 5FU for 24 h. 16595493 Human
glut-1 invasive breast cancer The aim of this study was therefore to explore the role of p53 and p300 in relation to overexpression of HIF-1alpha and activation of HIF-1 downstream genes in invasive breast cancer. p300 immunohistochemistry was performed in a group of 183 early-stage i 16867872 Human
glut-1 invasive breast cancers The aim of this study was therefore to explore the role of p53 and p300 in relation to overexpression of HIF-1alpha and activation of HIF-1 downstream genes in invasive breast cancer. p300 immunohistochemistry was performed in a group of 183 early-stage i 16867872 Human
glut-1 invasive breast cancer GLUT-1 levels were significantly associated with p300 in HIF-1alpha positive patients (P = .02). p53 accumulation significantly positively correlated with carbonic anhydrase IX (CAIX)/GLUT-1 coexpression in HIF-1alpha-positive patients (P = .007). p53 acc 16867872 Human
slc2a1 esophageal squamous cell carcinoma Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. 16391802 Human
slc2a1 esophageal squamous cell carcinoma We have carried out SEREX (serological identification of antigens by recombinant cDNA expression cloning), and identified SLC2A1 (solute carrier family 2/facilitated glucose transporter, member 1) as an antigen recognized by serum IgG antibodies in patien 16391802 Human
glut 1 cholangiocarcinoma Low expression of Glut 1 was reported in hepatocellular carcinoma (HCC), whereas high expression was found in cholangiocarcinoma. 16204727 Human
glut1 non-keratinizing carcinomas In contrast, in non-keratinizing carcinomas, p63 and phospho-histone H1 expression was most commonly observed throughout tumour nests and anti-GLUT1 stained in a pattern suggestive of hypoxia-induced expression ('antistromal' staining), in which 16681688 Human
glut1 axillary lymph node metastasis No significant correlation was seen between GLUT1 expression and clinical prognostic parameters such as tumor size (p = 0.085), age (p = 0.4528), axillary lymph node metastasis (p = 0.9562), nuclear grade (p = 0.6895), estrogen receptor-positive (p = 1.00 16849102 Human
glut-1 thyroglossal duct cyst Subsequent excisional biopsies in these cases revealed 4 cases of metastatic SCC (3 positive and 1 negative for GLUT-1), 1 case of BCC (negative for GLUT-1), and 1 case of thyroglossal duct cyst (negative for GLUT-1). 16435376 Human
glut-1 early-stage invasive breast cancers The aim of this study was therefore to explore the role of p53 and p300 in relation to overexpression of HIF-1alpha and activation of HIF-1 downstream genes in invasive breast cancer. p300 immunohistochemistry was performed in a group of 183 early-stage i 16867872 Human
glut-1 experimental sarcomas Lack of association between tumor hypoxia, GLUT-1 expression and glucose uptake in experimental sarcomas. 12580405 others
glut1 tumor antigen Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter. 8524814 Mouse
glut1 carcinogenesis We have also shown that Glut1 is expressed as a late event during colorectal carcinogenesis. 9149888 Human
glut1 lymphoma With the use of standard avidin-biotin immunostaining for GLUT1, we examined cell blocks of body cavity effusions or washings from 31 carcinomas, 1 lymphoma, and 25 benign effusions or washes. 9578091 Human
glut1 carcinogenesis It is concluded that (a) Glut1 is expressed as a late event in the carcinogenesis process in human colorectal cancer, and (b) expression of Glut1 in a high proportion of cancer cells is associated with a high incidence of lymph node metastases. 9816281 Human
glut1 oncogenic The type 1 glucose transporter (GLUT1) gene encodes an integral membrane glycoprotein responsible for facilitating transfer of glucose across plasma membrane and is rapidly activated by serum, growth factors, and by oncogenic transformation. 1339457 Human
glut-1 meningiomas All 7 tumors expressed Glut-1 and Glut-3 mRNA and Glut-3 appeared to be more abundant in meningiomas. 8265814 Human
glut 1 hepatocarcinogenesis Reduction in the expression of glucose transporter protein GLUT 2 in preneoplastic and neoplastic hepatic lesions and reexpression of GLUT 1 in late stages of hepatocarcinogenesis. 8364915 Rat
glut 1 hepatocarcinogenesis Expression of two important glucose transporter proteins, GLUT 2 (which is the typical glucose transporter in hepatocytes of adult liver) and the erythroid/brain type glucose transporter GLUT 1 (representing the typical glucose transporter in fetal liver 8364915 Human
glut-1 malignant transformation Thus, the expression of GLUT-1 appears to be a potential marker of malignant transformation. 17192790 Human
slc2a1 lymph node metastasis Clinicopathological analyses of carcinoma patients revealed a significant correlation of the VEGF and SLC2A1 expression with the status of lymph-vascular involvement and lymph node metastasis. 17342330 Human
glut 1 pheochromocytomas Expression of GLUT 1 through GLUT 5 was examined by Western blot analysis of tumor tissue from eight of the patients evaluated and an additional panel of 10 MTCs and seven pheochromocytomas. 9426419 Human
glut 1 osteogenic sarcoma Dexamethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line. 8863182 Human
glut 1 osteosarcoma We report the co-expression of GLUT 1 and GLUT 3 mRNA and protein in UMR 106-01, a clonal osteosarcoma cell line. 8579592 Human
glut 1 metastases In squamous cell carcinomas of the head and neck (HNSCC) and metastases, GLUT 1 was always expressed strongly. 9935199 Human
glut 1 melanoma Our present study suggests that both the proliferation rate and the cell viability of melanoma cells may be key factors for FDG uptake and that HK activity, rather than GLUT 1 expression, seems to be a major factor. 16043894 Human
glut1 malignant transformation CONCLUSIONS: Gastric cancer cells may acquire the ability to produce GLUT1 mRNA by malignant transformation. 10522065 Human
glut1 oncogenic Oncogenic transformation and hypoxia both induce glut1 mRNA. 11120745 Human
glut1 malignant transformation Glut1 expression is thought to be a potential marker for malignant transformation. 11166147 Human
glut1 adenocarcinomas Significantly more adenocarcinomas expressed ASCT1 than squamous cell carcinomas (p < 0.0001), whereas Glut1 expression was similar in both tumor types. 11268453 Human
glut1 carcinogenesis The innovative finding that GLUT1 and FAS are observed in mammary carcinoma adjacent nonneoplastic tissues may suggest a role in detecting initial phases of breast carcinogenesis. 11447743 Human
glut1 solid tumor This study investigates the relationship between FDG uptake as determined by positron emission tomography (PET) imaging and rates of tumor growth, cellular GLUT1 transporter density, and the activities of hexokinase and glucose-6-phosphatase in a solid tu 11494112 Human
glut1 hepatic metastasis Glut1-positive and Glut1-negative carcinomas were analyzed for their clinicopathologic characteristics including histologic subtype, depth of invasion, vascular permeation, lymph node and hepatic metastasis, peritoneal dissemination, and prognosis. 11505409 Human
glut1 infantile hemangioma MAIN OUTCOME MEASURES: Histologic appearance, immunoreactivity for the infantile hemangioma-associated antigens GLUT1 and LeY, and clinical behavior. 11735711 Human
glut1 peripheral nerve sheath tumors Immunohistochemical demonstration of EMA/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. 12692193 Human
glut1 perineurial cell tumors Perineurial cell tumors (benign and malignant) were composed of EMA/Glut1-positive and S-100 protein-negative tumor cells. 12692193 Human
glut1 rcc CONCLUSION: that GLUT1 immunoreactivity patterns reliably distinguish hemangioblastoma from RCC. 14606586 Human
glut1 malignant transformation GLUT1 messenger RNA and protein induction relates to the malignant transformation of cervical cancer. 14608894 Human
glut1 infantile hemangioma Our results indicate that there are two fundamentally different hepatic vascular lesions in infants and young children: GLUT1-positive hepatic infantile hemangioma (HIH) and GLUT1-negative hepatic vascular malformation with capillary proliferation (HVMCP) 14991538 Human
glut1 rhabdomyosarcoma Transient cotransfection of osteosarcoma-derived SaOS-2 cells, rhabdomyosarcoma-derived RD cells, and C2C12 myotubes with GLUT1-P-Luc or GLUT4-P-Luc promoter-reporter constructs and wild-type p53 expression vectors dose dependently decreased both GLUT1 an 15059920 Human
glut1 osteosarcoma Transient cotransfection of osteosarcoma-derived SaOS-2 cells, rhabdomyosarcoma-derived RD cells, and C2C12 myotubes with GLUT1-P-Luc or GLUT4-P-Luc promoter-reporter constructs and wild-type p53 expression vectors dose dependently decreased both GLUT1 an 15059920 Human
glut1 carcinogenesis These results are consistent with the theory that GLUT1 is upregulated during carcinogenesis and may play a major role in enhanced glucose uptake in thyroid cancer cells. 15588375 Human
glut1 colon carcinoma The cellular uptake of all 99mTc-complexes into HT-29 colon carcinoma cells via Glut1 was generally low and unspecific independent of the position at the hexose ring, the chelating systems, or the overall charge of the corresponding metal complexes. 15656581 Human
glut1 rcc Finally, cell-density-mediated induction of HIF-1alpha and GLUT1 in RCC cells could be completely reconstituted by mutations in VHL binding affinity, suggesting that cell-density dependent induction of HIF-1alpha and transactivation may underpin some of t 15750626 Human
glut1 malignant transformation CONCLUSIONS: (1) The expression of GLUT1 may be closely related to malignant transformation of ovarian epithelial tumors. 15924676 Human
glut1 carcinogenesis CONCLUSIONS: The overexpressions of Glut1 and HIF-1alpha play important roles in carcinogenesis and progression of colorectal adenocarcinoma, and closely correlate with cell proliferation of colorectal adenocarcinoma. 15946479 Human
glut1 primary tumors PURPOSE: To investigate hypoxia measured by pimonidazole binding, glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CA-IX) expression, proliferation, and vascularity in liver metastases of colorectal cancer and to compare GLUT1 and CA-IX expression 16242253 Human
glut1 primary tumors Thirteen paraffin-embedded primary tumors were stained immunohistochemically for GLUT1 and CA-IX expression, which was analyzed semiquantitatively in primary tumors and corresponding liver metastases. 16242253 Human
glut1 primary tumors Expression of CA-IX in primary tumors and metastases showed a significant correlation, which was absent for GLUT1 expression. 16242253 Human
glut1 ccrcc This study suggests that GLUT1 is one of a number of genes that may increase susceptibility to developing CCRCC. 16337858 Human
glut1 carcinogenesis CONCLUSIONS: GLUT1 is expressed in the vast majority of USPC and EIC, suggesting a biological role during the early steps of carcinogenesis in endometrial serous neoplasms. 16842248 Human
glut1 endometrial adenocarcinoma GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma. 16892013 Human
glut1 endometrial cancer The following experiments were conducted to quantify and localize the expression of GLUT1 and GLUT8 in benign endometrium and compare this expression to endometrial cancer. 16892013 Human
glut1 endometrial cancer A 44 and a 35.4 kDa immunoreacive species was demonstrated in endometrium and endometrial cancer for GLUT1 and GLUT8, respectively. 16892013 Human
glut1 endometrial cancer GLUT1 and GLUT8 are expressed in both human endometrium and endometrial cancer. 16892013 Human
glut1 vascular tumours GLUT1 stains 100% of infantile haemangiomas and none of the other infantile vascular tumours. 16997442 Human
glut1 tumorigenesis Only few studies have evaluated the usefulness of the GLUT1 and p63 status of thyroid carcinomas in revealing tumorigenesis. 17029809 Human
glut1 papillary carcinoma GLUT1 was detected in six cases of anaplastic carcinoma and in one case of poorly differentiated carcinoma with membranous staining. p63 was detected in five cases of anaplastic carcinoma, in one case of poorly differentiated carcinoma, and in five cases 17029809 Human
glut1 anaplastic carcinoma GLUT1 was detected in six cases of anaplastic carcinoma and in one case of poorly differentiated carcinoma with membranous staining. p63 was detected in five cases of anaplastic carcinoma, in one case of poorly differentiated carcinoma, and in five cases 17029809 Human
glut1 follicular carcinoma GLUT1 was detected in six cases of anaplastic carcinoma and in one case of poorly differentiated carcinoma with membranous staining. p63 was detected in five cases of anaplastic carcinoma, in one case of poorly differentiated carcinoma, and in five cases 17029809 Human
glut1 thyroid tumor The results suggest that GLUT1, p63, and p53 are not expressed in well-differentiated thyroid carcinomas, and that they are usually expressed late in the course of thyroid tumor progression. 17029809 Human
glut1 well-differentiated thyroid carcinomas The results suggest that GLUT1, p63, and p53 are not expressed in well-differentiated thyroid carcinomas, and that they are usually expressed late in the course of thyroid tumor progression. 17029809 Human
glut1 anaplastic carcinomas These data strongly suggest that in anaplastic carcinomas, impairment of p53-mediated repression results in increased GLUT1 and p63 expression, and that this probably reflects the differential regulation of hypoxia-responsive pathways and basal/stem cell 17029809 Human
glut1 pancreatic cancer In this paper we studied the expression and hypoxic regulation of PFKFB-4 and PFKFB-3 mRNA as well as its correlation with HIF-1alpha, HIF-2alpha, VEGF and Glut1 mRNA expression in the pancreatic cancer cell line Panc1 and two gastric cancer cell lines MK 17143338 Human
glut1 pancreatic cancer The expression of VEGF and Glut1, which are known HIF-dependent genes, is also strongly induced under hypoxic conditions in gastric and pancreatic cancer cell lines. 17143338 Human
glut hnscc We have used immunohistochemistry ot study the expression of different facilitative glucose transport proteins (GLUT) in the normal mucosa and in HNSCC. 10506498 Human
glut primary tumors Our results show that the gene expression pattern of the GLUT family is different between primary and metastatic liver tumors and suggest that the energy transporters in metastatic tumors may be different from those in primary tumors. 10622535 Human
glut carcinogenesis Here, using either a model of multistage epidermal carcinogenesis in K14-HPV16 transgenic mice or creation of full-thickness back wounds in nontransgenic mice, we determined patterns of expression of hypoxia inducible factor (HIF)-1alpha, and three target 11085544 Human
glut malignant transformation The aim of the present study was to analyze the expression of different GLUT isoforms (GLUT1-4) and to investigate whether alterations in their expression pattern accompany the malignant transformation and progression of ovarian cancer. 15331928 Human
glut-1 tcc We hypothesized that human erythrocyte glucose transporter (Glut-1) expression is increased in bladder transitional cell carcinoma (TCC) and that the grade of expression might correlate with the degree of malignancy. 10699635 Human
glut-1 carcinogenesis In epidermal carcinogenesis, HIF-1alpha, GLUT-1, PGK-1, and VEGF mRNAs were just detectable in early-stage hyperplasia, markedly increased in high-grade epidermal chest dysplasias, and further increased in invasive squamous carcinomas. 11085544 Human
glut-1 bronchioloalveolar adenocarcinomas Of seven bronchioloalveolar carcinomas, six (85.7%) were negative for the expression of Glut-1, while only one (4.3%) of 23 non-bronchioloalveolar adenocarcinomas was negative (P < 0.0001). 11189940 Human
glut-1 bronchioloalveolar adenocarcinomas The percentages of Glut-1-positive area, as well as the SUVs, were significantly lower in bronchioloalveolar carcinomas (n = 7) (2.86% +/- 7.56% and 1.25 +/- 0.75, respectively) than in non-bronchioloalveolar adenocarcinomas (n = 23) (54.83% +/- 25.64%, P 11189940 Human
glut-1 bronchioloalveolar carcinomas The percentages of Glut-1-positive area, as well as the SUVs, were significantly lower in bronchioloalveolar carcinomas (n = 7) (2.86% +/- 7.56% and 1.25 +/- 0.75, respectively) than in non-bronchioloalveolar adenocarcinomas (n = 23) (54.83% +/- 25.64%, P 11189940 Human
glut-1 adenocarcinoma of the lung The degree of cell differentiation correlated with the percentage of Glut-1-positive area and SUVs in adenocarcinoma of the lung. 11189940 Human
glut-1 malignant transformation Glucose transporter 1 (GLUT-1) is recognized as a major early marker of cellular malignant transformation. 11972644 Human
glut-1 lymphoma Differential FDG accumulation associated with GLUT-1 expression in a patient with lymphoma. 12932118 Human
glut-1 lymphoma This case suggests that the differential FDG accumulation shown by lesions is associated with the degree of GLUT-1 expression in patients with lymphoma. 12932118 Human
glut-1 juvenile hemangioma Thirty-three cases of KH were reviewed and immunostained for alpha-smooth muscle actin, various endothelial markers (CD31, CD34, vWf, FLI1), a platelet marker (CD61), and the juvenile hemangioma-associated markers GLUT-1 and Lewis Y antigen (LeY). 15105642 Human
glut-1 astroglioma GLUT-1-independent infection of the glioblastoma/astroglioma U87 cells by the human T cell leukemia virus type 1. 16781755 Human
glut-1 malignant transformation Although the aberrant expression of GLUT-1 has been reported in a wide spectrum of epithelial malignancies, its possible correlation with the malignant transformation of endometrial epithelium has not been clearly established. 16785788 Human
glut-1 malignant transformation These data suggest that the expression of GLUT-1 transporter may be closely related to the malignant transformation of epithelial endometrial tumors by supporting their increased need for glucose metabolism. 16785788 Human
glut-1 papillary thyroid carcinoma The role of immunolocalization of CD57 and GLUT-1 in cell blocks in fine-needle aspiration diagnosis of papillary thyroid carcinoma. 16944537 Human
glut-1 papillary carcinoma The usefulness of CD57 and GLUT-1 immunostaining was evaluated as an adjunct to assist in the diagnosis of papillary carcinoma in fine-needle aspirations (FNAs) of the thyroid. 16944537 Human
glut-1 papillary carcinoma METHODS: Immunohistochemical staining for CD57 and GLUT-1 was performed on paraffin-embedded cell blocks of 50 thyroid FNA cases with the following cytologic diagnoses: 1) papillary carcinoma (15 cases); 2) atypical cytology, cannot exclude papillary carc 16944537 Human
glut-1 papillary carcinomas GLUT-1 did not prove to be a useful marker in distinguishing papillary carcinomas. 16944537 Human
glut-1 rectal cancer Tumour expression of thymidylate synthase, thymidine phosphorylase, cyclin A, vascular endothelial growth factor (VEGF), carbonic anhydrase-9, hypoxia inducible factor-1alpha, and glucose transporter-1 (GLUT-1) proteins was determined before and after rec 17016487 Human
glut-1 renal cancer [Expression of hypoxia inducible factor-1alpha and glucose transporter protein 1 in renal and bladder cancers and the clinical significance thereof] OBJECTIVE: To investigate the protein expression of hypoxia inducible factor-1alpha (HIF-1alpha) and gluco 17064593 Human
glut-1 transitional cell carcinoma Immunohistochemistry was used to detect the protein expression of Glut-1 in tissue sections from 58 patients with bladder carcinoma transitional cell carcinoma and 38 patients with renal clear cell carcinoma resected during operation. 17064593 Human
glut-1 renal clear cell carcinoma Immunohistochemistry was used to detect the protein expression of Glut-1 in tissue sections from 58 patients with bladder carcinoma transitional cell carcinoma and 38 patients with renal clear cell carcinoma resected during operation. 17064593 Human
glut-1 renal clear cell carcinoma Protein expression of Glut-1 was not detected in the normal renal and bladder tissues, however, was significantly higher in the bladder TCC and renal clear cell carcinoma tissues. 17064593 Human
glut-1 renal clear cell carcinoma The protein expression of Glut-1 in the renal clear cell carcinoma was at a rate of 86.9% (33/38), however, it was not correlated with the grade and stage of the cancer. 17064593 Human
glut-1 renal clear cell carcinoma The protein expression of Glut-1 is strongly associated with the neoplastic progression of bladder TCC and renal clear cell carcinoma. 17064593 Human
glut-1 primary tumor The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. 17080242 Human
glut 1 hnscc In squamous cell carcinomas of the head and neck (HNSCC) and metastases, GLUT 1 was always expressed strongly. 9935199 Human
glut 1 hnscc The increased expression of GLUT 1 in dysplastic lesions and its sustained expression in SCC indicate that changes of GLUT 1 expression are early events during development of HNSCC. 9935199 Human
glut 1 hnscc However, the expression of GLUT 1 was strongly elevated in epithelial cells of HNSCC. 10506498 Human
glut 1 hnscc The present study with PET indicates that the elevated glucose uptake of HNSCC is closely related to an increased expression of GLUT 1 in epithelial tumor cells. 10506498 Human

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