IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SPP1 Ensembl ENSG00000118785 Chromosome 4 Start 89115826 End 89123586
Description Osteopontin Precursor (Bone sialoprotein 1)(Secreted phosphoprotein 1)(SPP-1)(Urinary stone protein)(Nephropontin)(Uropontin) [Source:UniProtKB/Swiss-Prot;Acc:P10451]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11255
     Entrez Gene : 6696
     UCSC : uc003hra.2
     GeneCards : 11255
     RefSeq : NM_000582
     CCDS : CCDS3626.1
     Uniprot : P10451
     Interpro : P10451
     OMIM : 166490
     GeneTests : SPP1
     CGAP : SPP1
     PMID : 1575754

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 15/40(38%) IHC- 11520606 Cancer Lett. 2001 Oct 10;171(2):215-22.
up 205/318(65%) IHCNodal status(P< 0.001)//Stage(P< 0.001)//Tumor size(P< 0.001) 16000556 Clin Cancer Res. 2005 Jul 1;11(13):4646-52.
up 40/82(49%) qRT-PCRSurvival curves(P=0.014) 15014008 Clin Cancer Res. 2004 Mar 1;10(5):1588-96.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  2092_s_at  3.72  3.15e-30  8.64e-28  3.61  8.92e-13  1.81e-11
 HG_U95  34342_s_at  4.11  1.29e-32  5.27e-30  3.95  2.68e-11  4.01e-10
 HG_U133A  209875_s_at  4.08  6.63e-99  3.08e-96  -2.26  1.17e-39  2.26e-39
 HG_U133_Plus2  1568574_x_at  2.79  3.75e-18  7.30e-17  3.16  1.64e-14  1.22e-13
 HG_U133_Plus2  209875_s_at  3.80  2.98e-56  6.28e-53  3.86  4.12e-35  3.61e-33
 Stanford  15652  3.40  1.36e-4  3.99e-3  4.39  2.53e-6  1.85e-4
 Agilent_HS_21.6K  6138  1.02  6.99e-5  8.93e-4  1.21  1.12e-5  1.24e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209875_s_at  0.53  3.56e-1  8.92e-1  -0.33  3.75e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 2092_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 34342_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209875_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1568574_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209875_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15652    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6138    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
spp1 carcinogenesis Among these, cyclooxygenase-2 (Cox-2/Ptgs2) and osteopontin (Opn/Spp1) are known to be functionally significant in driving carcinogenesis. 17363560 Human
opn cysts OPN was detected in 80% (48/60) of cysts by Western blotting and distributed in the side of "exocyst" layer directing to the parasite, also macrophages were identified in the vicinity of OPN by immunohistochemistry staining. 17129569 Human
opn cysts The coexpression of OPN and CD68 was observed by immunofluorescence double labeling and analyzed by Image-Pro Plus 5.1; with special stain techniques, variable degrees of calcium deposits were observed in 80% (48/60) cysts, and the calcium deposits concur 17129569 Human
opn inflammatory bowel disease AIM: To determine whether plasma OPN levels in patients with inflammatory bowel disease are associated with disease activity. 17245215 Human
opn crohn's disease RESULTS: Plasma OPN concentrations were significantly higher in patients with Crohn's disease than in controls (951.9+/-538.5 ng/mL and 659.0+/-163.7 ng/mL, respectively). 17245215 Human
opn esophageal squamous carcinoma [Expression of Ras-GTPase-activating protein SH 3 domain binding protein and osteopontin in esophageal squamous carcinoma and their effects on prognosis] OBJECTIVE: To investigate the expressions and significances of Ras-GTPase-activating protein SH 3 dom 17253181 Human
opn esophageal squamous carcinoma (esc) [Expression of Ras-GTPase-activating protein SH 3 domain binding protein and osteopontin in esophageal squamous carcinoma and their effects on prognosis] OBJECTIVE: To investigate the expressions and significances of Ras-GTPase-activating protein SH 3 dom 17253181 Human
opn benign prostatic hyperplasia METHODS: OPN and the bone markers carboxyterminal-telopeptide of type I collagen, bone-specific alkaline phosphatase (bALP), and aminoterminal-propeptide of type I procollagen (PINP) were measured in 90 PCa patients with and without bone metastases, 35 pa 17192877 Human
opn cyst The pericyst of hepatic E. granulosus consists of two detachable layers with different formative mechanisms: the "exocyst" layer directing towards the cyst of parasite was the result of granulomatous reaction; also the results suggest OPN is one 17129569 Human
opn uveal melanoma METHODS: Twenty-eight plasma samples of 27 patients with uveal melanoma were analyzed, and the OPN plasma levels were quantified. 17386288 Human
opn metastatic disease In contrast, increased median levels of OPN of 170.72 ng/ml (range, 87.37 to 375.54 ng/ml, P <.001) were seen in eight patients with proven metastatic disease. 17386288 Human
opn uveal melanoma Healthy patients without uveal melanoma showed a median plasma concentration of OPN of 54.6 ng/ml (range, 38.23 to 71.21 ng/ml). 17386288 Human
opn gastrointestinal cancer Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. 17332338 Human
opn human gastric cancer In this study, we show that both OPN and CD44(V) are frequently overexpressed in human gastric cancer and that OPN-engaged CD44(V) ligation confers cells an increased survival mediated through integrin activation. 17332338 Human
opn gastric cancer Taken together, we showed that OPN-CD44(V) interaction promotes ECM-derived survival signal mediated through integrin activation, which may play an important role in the pathogenic development and progression of gastric cancer. 17332338 Human
opn carcinogenesis Among these, cyclooxygenase-2 (Cox-2/Ptgs2) and osteopontin (Opn/Spp1) are known to be functionally significant in driving carcinogenesis. 17363560 Human
opn uveal melanoma PURPOSE: To evaluate the protein osteopontin (OPN) as a potential new marker for screening and detection of metastatic uveal melanoma. 17386288 Human
opn metastatic disease CONCLUSION: The protein OPN seems to be a promising tumor marker for detecting metastatic disease in patients with uveal melanoma. 17386288 Human
opn uveal melanoma CONCLUSION: The protein OPN seems to be a promising tumor marker for detecting metastatic disease in patients with uveal melanoma. 17386288 Human
opn metastasis Osteopontin (OPN) is a multifunctional protein implicated in mammary development, neoplastic change, and metastasis. 14990565 Human
opn human breast cancers This study shows that beta-catenin/Lef-1, Ets, and AP-1 transcription factors can cooperate in a rat mammary cell line in stimulating transcription of OPN and that their independent presence is associated with that of OPN in a group of human breast cancer 14990565 Human
opn metastasis These results suggest that the presence of these transcription factors in human breast cancer is responsible in part for the overexpression of OPN that, in turn, is implicated in mammary neoplastic progression and metastasis. 14990565 Human
opn monocytic leukemia In the present study, we investigated the molecular mechanisms regulating OPN gene expression by PPARgamma in THP-1 cells, a cell line derived from human monocytic leukemia cells. 11861425 Human
opn tumor OPN synthesized by tumor cells stimulates tumor growth, but the mechanism by which the protein acts remains unclear. 11741994 Human
opn tumor angiogenesis To provide evidence of OPN involvement in a causal role in tumor angiogenesis, we generated a stable transfectant from murine neuroblastoma C1300 cells to constitutively secrete high levels of murine OPN. 11920639 Human
opn murine neuroblastoma To provide evidence of OPN involvement in a causal role in tumor angiogenesis, we generated a stable transfectant from murine neuroblastoma C1300 cells to constitutively secrete high levels of murine OPN. 11920639 Human
opn tumor angiogenesis Conclusively, these results provide direct evidence of OPN involvement in the role of tumor angiogenesis. 11920639 Mouse
opn stage-ii breast cancer We now show that a monoclonal antibody to rat OPN recognizes specifically human OPN using Western blotting techniques andused it to assess the prognostic significance of OPN in primary tumors of a group of 333 patients treated between 1976 and 1982 for op 12067984 Human
opn metastatic human breast cancer We, therefore, examined the gene expression pattern of the TGF-beta family members (inhibin/activin betaA subunit (activin betaA), inhibin alpha subunit, and bone morphogenetic protein-2 (BMP-2)), the TNF family members (receptor activator of NF-KB ligand 12206515 Human
opn breast tumor The mRNA level of OPN, a bone matrix protein associated with enhanced malignancy, increased in non-invasive, invasive, and liver and bone metastatic breast tumor tissue compared to normal breast tissue. 12206515 Human
opn breast tumor These results suggest that differential gene expression of bone-related proteins, especially OPN, activin betaA, and BMP-2, by primary breast tumor tissues may play a significant role in the invasiveness and metastatic potential of breast cancer. 12206515 Human
opn malignant bone tumors In this study we determined the expression of OPN in benign and malignant bone tumors and investigated the prognostic influence of OPN expression on the outcome of osteosarcoma patients. 12404059 Human
opn metastatic breast cancer Recent studies reported an increased expression of osteopontin (OPN) in metastatic breast cancer cells, but the mechanisms modulating OPN production and the interaction of the cells with the secreted protein are far from clear. 12456016 Human
opn kidney cancer In addition to already known tumor-associated genes, the majority of identified genes have not yet been brought into context with tumorigenesis such as genes involved in bone matrix mineralization (OSN, OPN, and OSF-2) in lung, breast, and kidney cancer o 14871811 Human
opn lung cancer However, differential OPN expression and its regulation in each histologic type of lung cancer are not well established. 11520606 Human
opn lung cancer In this study, we assessed expression of OPN in lung cancer tissues with immunohistochemical analysis. 11520606 Human
opn non-small cell lung cancer OPN was predominantly expressed in tumor cells of non-small cell lung cancer (NSCLC) tissues: 11 of 16 cases (68.8%) of squamous cell carcinoma (SCC), five of 24 cases (20.8%) of adenocarcinoma (AD), but only two of 18 cases (11%) of small cell lung cance 11520606 Human
opn lung adenocarcinoma INTRODUCTION: Previously, we and others have shown that bone extracellular matrix proteins such as bone sialoprotein (BSP) and osteopontin (OPN) are expressed in various types of cancer that are characterized by a high affinity for bone including breast, 12929940 Human
opn sarcomas The expression of OPN in macrophages and tumor cells indicates that this molecule could possibly mediate cellular adhesion of both cell types in pulmonary sarcomas. 11764388 Human
opn metastatic breast cancer We also summarize clinical studies that show that OPN levels in tumors and blood are elevated in women with metastatic breast cancer and may offer promise as prognostic markers in breast cancer. 12013531 Human
eta-1 granulomas Mice deficient in Eta-1 (also called osteopontin) gene expression have severely impaired type-1 immunity to viral infection [herpes simplex virus-type 1 (KOS strain)] and bacterial infection (Listeria monocytogenes) and do not develop sarcoid-type granulo 10657301 Mouse
opn metastatic breast cancer A distinct co-localization of perimembranous OPN and cell-surface CD44 was observed in fetal fibroblasts, periodontal ligament cells, activated macrophages, and metastatic breast cancer cells. 10825241 Human
opn malignant astrocytoma We investigated the transcriptional regulation of OPN in the U-251MG and U-87MG human malignant astrocytoma cell lines. 11126367 Human
opn intraductal breast carcinoma To investigate the relationship between BSP expression and the formation of bone metastases we have conducted an initial study of the expression of BSP in 10 intraductal breast carcinoma bone metastases using immunostaining and in situ hybridization, and 11315099 Human
opn pleomorphic adenomas We immunohistochemically investigated the presence and the distribution of OSN and OPN in 43 pleomorphic adenomas to elucidate the production of their molecules by modified myoepithelial cells. 10605692 Human
opn pleomorphic adenomas OPN was strongly expressed in the stroma of the myxoid and hyaline areas of the pleomorphic adenomas (65.1%), but there was no expression of OPN in the chondroid area. 10605692 Human
opn pleomorphic adenomas These findings suggested that OSN was related to the production of the type IV collagen by modified myoepithelial cells, whereas OPN was involved in the stromal formation of myxoid or hyaline tissues in pleomorphic adenomas. 10605692 Human
opn pleomorphic adenomas In summary, pleomorphic adenomas expressed the bone matrix proteins OSN and OPN. 10605692 Human
opn oral squamous-cell carcinoma (oscc) The objectives of this study were to assess the immunolocalization of human osteopontin (OPN) in oral lesions and to identify human cell lines of oral squamous cell carcinoma (OSCC) origin that express OPN mRNA. 10069535 Human
opn carcinoma in situ OPN was localized using immunohistochemistry in the following oral specimens: normal epithelium (n=6), epithelial hyperplasia (n=4), epithelial dysplasia (n=28), carcinoma in situ (n=11) and squamous cell carcinoma (n=43). 10069535 Human
opn epithelial hyperplasia OPN was localized using immunohistochemistry in the following oral specimens: normal epithelium (n=6), epithelial hyperplasia (n=4), epithelial dysplasia (n=28), carcinoma in situ (n=11) and squamous cell carcinoma (n=43). 10069535 Human
opn pulmonary granuloma Opn is among the most abundantly expressed proteins in a range of lung diseases and has been shown to regulate aspects of pulmonary granuloma formation, fibrosis, and malignancy. 14563350 Human
opn ovarian cancer OBJECTIVE: Osteopontin (OPN) is overexpressed in tumors and serum of ovarian cancer patients and may serve as a biomarker. 15099946 Human
opn pancreatic adenocarcinoma In this study, we evaluate OPN as a serum marker of pancreatic adenocarcinoma. 15006928 Human
opn pancreatic adenocarcinoma METHODS: In situ hybridization for OPN was performed on a pancreatic adenocarcinoma tissue microarray. 15006928 Human
opn pancreatic adenocarcinomas RESULTS: In situ hybridization for OPN performed on a tissue microarray revealed strong OPN mRNA signal in tumor-infiltrating macrophages in 8 of 14 pancreatic adenocarcinomas. 15006928 Human
opn pancreatic adenocarcinoma Serum OPN levels, as measured by ELISA, were elevated in the sera of 50 patients with resectable pancreatic adenocarcinoma compared to 22 healthy control individuals (mean +/- SD for OPN was 482 +/- 170 ng/ml and 204 +/- 65 ng/ml, respectively; P < 0.001) 15006928 Human
opn breast cancer We have recently reported that osteopontin (OPN) stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase-type plasminogen activator (uPA) through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells (Das, 14704150 Human
opn intrahepatic cholangiocarcinoma The aim of this study was to determine whether the expression of OPN in cases of intrahepatic cholangiocarcinoma (ICC) indicates the clinical outcome. 15101999 Human
opn icc The aim of this study was to determine whether the expression of OPN in cases of intrahepatic cholangiocarcinoma (ICC) indicates the clinical outcome. 15101999 Human
opn icc METHODS: The expression of OPN protein was investigated immunohistochemically in surgically resected specimens from 73 patients, and the level of OPN mRNA was also examined by quantitative real-time reverse transcription-polymerase chain reaction (real-ti 15101999 Human
opn icc We examined the correlation between the expression of OPN and the clinicopathological factors, including overall survival, in patients with ICC. 15101999 Human
opn icc CONCLUSIONS: Decreased expression of OPN is considered to be a reliable indicator of tumor aggressiveness and clinical outcome in patients with ICC. 15101999 Human
opn invasive breast carcinoma To determine the origin and incidence of BSP and OPN mRNA expression in primary tumor, a cohort of archival, primary invasive breast carcinoma specimens was analyzed. 10418827 Human
opn in-situ carcinoma In general, BSP and OPN transcripts were detected in both invasive and in situ carcinoma components. 10418827 Human
opn breast tumors Our data suggest that in human primary breast tumors, the origin of BSP and OPN mRNA is predominantly the breast cancer cells and that expression of these transcripts is influenced by the tumor environment. 10418827 Human
opn tumor angiogenesis To clarify the cooperative role of VEGF and OPN in tumor angiogenesis, we stained VEGF, OPN, and CD34 immunohistochemically in 87 cases of stage I non-small cell lung cancer (adenocarcinoma, 55, and squamous cell carcinoma, 32). 10508818 Human
opn stage i non-small cell lung cancer To clarify the cooperative role of VEGF and OPN in tumor angiogenesis, we stained VEGF, OPN, and CD34 immunohistochemically in 87 cases of stage I non-small cell lung cancer (adenocarcinoma, 55, and squamous cell carcinoma, 32). 10508818 Human
opn stage i lung adenocarcinoma Cooperation of OPN is important in VEGF-mediated tumor angiogenesis in stage I lung adenocarcinoma. 10508818 Human
opn tumor angiogenesis Cooperation of OPN is important in VEGF-mediated tumor angiogenesis in stage I lung adenocarcinoma. 10508818 Human
opn metastatic cancer Consequently, the OPN gene was found to be upregulated among various metastatic cancer cells. 14712233 Human
opn metastatic cancer How the OPN gene is upregulated in metastatic cancer cells remains to be illustrated. 14712233 Human
opn metastatic cancer Thus, we investigated the transcriptional activation of the OPN promoter in the human metastatic cancer cell line A2058. 14712233 Human
opn metastatic tumor Our results suggest that AML-1 and C/EBPalpha play an important role in the upregulation of the OPN gene in metastatic tumor cells. 14712233 Human
opn liver carcinoma In this study, immortalized liver carcinoma cells (HepG2) were used to examine the effect of OPN on two isoforms of CD44: CD44 standard (CD44 s) and CD44v6. 12949055 Human
opn axillary lymph node metastases The development of right axillary lymph node metastases, chest wall recurrence, and distant metastases was associated in all instances with an immunohistochemical profile of high level expression of OPN and p53. 9199622 Human
opn murine neuroblastoma We have recently reported that culture medium with murine neuroblastoma C1300 cells transfected with OPN gene significantly stimulates human umbilical vein endothelial cell migration and induces neovascularization in mice by dorsal air sac assay. 12893437 Mouse
opn infiltrating ductal carcinomas METHODS: Sixty-eight fresh, frozen specimens including 31 primary infiltrating ductal carcinomas, 22 nodal metastases, 10 fibroadenomas, and five normal breast tissues were evaluated for OPN expression, TSP-1 expression and TYRP-1 expression. 12927044 Human
opn metastatic carcinomas Both OPN and TSP-1 expression were significantly higher in malignant epithelial sources over normal and benign epithelial sources, but no difference in expression levels was evident between primary tumors with or without metastases, nor between primary an 12927044 Human
opn mgus In addition, we measured plasma OPN concentrations by ELISA in 30 MM patients, 21 monoclonal gammopathy of undetermined significance (MGUS) patients and 30 healthy volunteers. 14531907 Human
opn monoclonal gammopathy of undetermined significance In addition, we measured plasma OPN concentrations by ELISA in 30 MM patients, 21 monoclonal gammopathy of undetermined significance (MGUS) patients and 30 healthy volunteers. 14531907 Human
opn mgus As a result, in an immunocytochemical study, abundant OPN was detected in BMCs from overt MM patients, whereas no OPN was detected in BMCs from patients with other haematological diseases, including MGUS. 14531907 Human
opn mgus Cultured BMCs from overt MM patients produced more OPN than those from patients with either smouldering MM or MGUS. 14531907 Human
opn mgus Plasma OPN levels of MM patients were significantly higher than those of MGUS patients and healthy volunteers (P < 0.05). 14531907 Human
opn mgus Plasma OPN levels may be a useful biomarker for assessing bone destruction in MM and distinguishing MM from MGUS or smouldering MM. 14531907 Human
opn melanoma We have recently reported that osteopontin (OPN) stimulates tumor growth and activation of promatrix metalloproteinase-2 (pro-MMP-2) through nuclear factor kappa B (NF kappa B)-mediated induction of membrane type 1 matrix metalloproteinase (MT1-MMP) in mu 12473670 Mouse
opn melanoma However, the molecular mechanism by which OPN activates NF kappa B and regulates pro-MMP-2 activation in murine melanoma (B16F10) cells is not well defined. 12473670 Human
opn complete mole RESULTS: Our results showed significantly lower expression of OPN mRNA and protein in hydatidiform mole, and in particular complete mole (P = 0.001 by real-time PCR and P < 0.001 by immunohistochemistry) as compared to nermal placenta. 12694667 Human
opn giant-cell tumour We show that osteopontin (OPN), bone sialoprotein (BSP) and GRGDSP peptides, in solution, induce activation of metalloproteinase-2 (MMP-2) secreted by human GCT23 giant cell tumour cells. 9639398 Human
opn gliomas Sixty-eight gliomas were immunohistochemically stained with TF, VEGF, OPN and alphavbeta3 integrin antibody. 10864205 Human
opn glioblastomas OPN and alphavbeta3 integrin, were also predominantly observed in the microvasculature of glioblastomas associated with VEGF expression. 10864205 Human
opn ovarian serous papillary cystadenocarcinomas These results suggest that OPN produced and promptly secreted by macrophages and subsequently translocated to psammoma bodies may be causally related with the calcium phosphate deposition in the psammoma bodies of the ovarian serous papillary cystadenocar 10886734 Human
opn squamous cell carcinoma of the oral cavity Osteopontin (OPN) distribution in premalignant and malignant lesions of oral epithelium and expression in cell lines derived from squamous cell carcinoma of the oral cavity. 10069535 Human
opn necrosis There is little information on the expression and role of OPN in gentamicin-induced acute tubular necrosis (ATN) and its recovery process. 11231351 Human
opn nsclc OPN was predominantly expressed in tumor cells of non-small cell lung cancer (NSCLC) tissues: 11 of 16 cases (68.8%) of squamous cell carcinoma (SCC), five of 24 cases (20.8%) of adenocarcinoma (AD), but only two of 18 cases (11%) of small cell lung cance 11520606 Human
opn nsclc Expectedly, OPN was principally expressed in NSCLC cell lines (H322 cells and HL460 cells) but not in SCLC cell line (H69 cells) by Western blotting and Northern blotting. 11520606 Human
opn nsclc Collectively, these results suggest that OPN is mainly expressed in NSCLC, especially among SCC. 11520606 Human
opn pulmonary sarcomas The expression of OPN in macrophages and tumor cells indicates that this molecule could possibly mediate cellular adhesion of both cell types in pulmonary sarcomas. 11764388 Human
opn mammary tumor Mammary tumor development was efficient in the 129 strain and was independent of osteopontin (OPN) expression. 12705632 Mouse
opn prostate tumours Moderate to strong OPN expression was found in 42% of all breast tumours and in 56% of all prostate tumours. 14524533 Human
opn breast tumours Moderate to strong OPN expression was found in 42% of all breast tumours and in 56% of all prostate tumours. 14524533 Human
opn prostate tumour Significantly more breast cancer bone metastases exhibited high OPN expression, 83%, as compared with prostate tumour bone metastases, 11% (P = 0.0019). 14524533 Human
opn benign tumors Elevated expression of OPN in malignant and benign tumors is postulated to play a role in tumorigenesis. 12919959 Human
opn lung metastases Immunohistochemical analysis revealed areas of osteopontin (Opn) expression in WAP-HGF tumors and lung metastases in agreement with a previously reported role for Opn in invasive growth. 14627990 Mouse
opn metastatic tumor We cloned the OPN promoter, and serial deletion analysis of the OPN promoter showed that the region between -170 and -127 may act as an enhancer to control the OPN gene in metastatic tumor cells. 14712233 Human
opn endometrial carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn transitional cell carcinomas of the renal pelvis RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn pancreatic carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn renal-cell carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn ovarian carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn esophageal carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn salivary gland cancers Although OPN expression was identified in a good number of bladder, prostate, and brain tumors, the majority of 6 skin cancers, 11 of 14 salivary gland cancers, 2 thyroid carcinomas, and 23 of 26 breast cancers revealed low OPN positivity or were negative 14734468 Human
opn skin cancers Although OPN expression was identified in a good number of bladder, prostate, and brain tumors, the majority of 6 skin cancers, 11 of 14 salivary gland cancers, 2 thyroid carcinomas, and 23 of 26 breast cancers revealed low OPN positivity or were negative 14734468 Human
opn thyroid carcinomas Although OPN expression was identified in a good number of bladder, prostate, and brain tumors, the majority of 6 skin cancers, 11 of 14 salivary gland cancers, 2 thyroid carcinomas, and 23 of 26 breast cancers revealed low OPN positivity or were negative 14734468 Human
opn brain tumors Although OPN expression was identified in a good number of bladder, prostate, and brain tumors, the majority of 6 skin cancers, 11 of 14 salivary gland cancers, 2 thyroid carcinomas, and 23 of 26 breast cancers revealed low OPN positivity or were negative 14734468 Human
opn infiltrating cancer In contrast, OPN expression was not seen in the pancreatic cancer cells themselves, nor was it seen in normal pancreatic tissue or in the macrophages distant from the infiltrating cancer. 15006928 Human
opn lung tumor PURPOSE: The purpose of this study was to better define the role of osteopontin (OPN) and osteonectin [also known as secreted protein acidic and rich in cysteine (SPARC)] in lung tumorigenesis by comparing the expressions of these genes in lung tumor tiss 15014008 Human
opn non-small cell lung cancer EXPERIMENTAL DESIGN: Quantitative real-time reverse transcription-PCR was used to analyze OPN and SPARC mRNA expression in normal lung tissue and matching tumor samples from 82 patients with non-small cell lung cancer. 15014008 Human
opn metastatic tumor RESULTS: With in vivo metastasis assays, the antisense Met cells showed no metastatic tumor formation to the lungs of recipient mice, while wild-type Met cells, with higher levels of OPN, showed significant amounts of metastasis. 15084239 Mouse
opn mammary tumors CONCLUSIONS: We conclude that OPN is an essential regulator of the metastatic phenotype seen in polyomavirus middle T-induced mammary tumors. 15084239 Human
opn advanced cancers Moreover, studies in a variety of human cancers associate high levels of OPN expression in tumours or in blood with more advanced cancers. 15138464 Human
opn necrosis To clarify the functional role of OPN in tubular injury, we performed in situ hybridization and immunohistochemical analysis of the expression of OPN in a renal cortical necrosis model induced by cisplatin from the acute injury to late recovery phases. 15292680 Human
opn melanoma However, the molecular mechanism(s) by which OPN regulates promatrix metalloproteinase-9 (pro-MMP-9) activation, MMP-9-dependent cell motility, and tumor growth and the involvement of upstream kinases in regulation of these processes in murine melanoma ce 15247285 Human
opn recurrent ovarian cancer The purpose of this study was to test the hypothesis that OPN is a clinically useful adjunct to CA125 in detecting recurrent ovarian cancer. 15161704 Human
opn recurrent ovarian cancer Longitudinal mixed effects polynomial models were used to determine whether OPN and CA125 levels correlated with the development of recurrent ovarian cancer. 15161704 Human
opn recurrent ovarian cancer CONCLUSIONS: OPN may be a clinically useful adjunct to CA125 in detecting recurrent ovarian cancer. 15161704 Human
opn tumor One such molecule, osteopontin (OPN), represents a key molecular signaling event in tumor progression and metastasis. 15347645 Human
opn epithelial tumor In this regard, we have examined the differential transcriptional regulation of OPN in the murine mammary epithelial tumor cell lines, 4T1 and 4T07, which are sublines derived from the parental population of 410.4 cells from Balb/cfC3H mice. 15347645 Human
opn malignancy These results provide new insight into the transcriptional regulation of OPN as a key mediator of metastatic behavior in malignancy. 15347645 Mouse
opn oral cancer We examined expression and function of osteopontin (OPN) in oral cancer cell lines using antisense oligonucleotide (AS). 15596299 Human
opn lung cancer RESULTS: Significantly elevated expression levels were observed for BSP in cancer of the breast, colon, stomach, rectum, thyroid, and kidney; OPN in cancer of the breast, uterus, colon, ovary, lung, rectum, and thyroid; DMP1 in cancer of the breast, uteru 15623631 Human
opn ovarian cancer The degree of correlation between a SIBLING and its partner MMP was found to be significant within a given cancer type (e.g., BSP and MMP-2 in colon cancer, OPN and MMP-3 in ovarian cancer; DMP1 and MMP-9 in lung cancer). 15623631 Human
opn colon cancer The degree of correlation between a SIBLING and its partner MMP was found to be significant within a given cancer type (e.g., BSP and MMP-2 in colon cancer, OPN and MMP-3 in ovarian cancer; DMP1 and MMP-9 in lung cancer). 15623631 Human
opn lung cancer The degree of correlation between a SIBLING and its partner MMP was found to be significant within a given cancer type (e.g., BSP and MMP-2 in colon cancer, OPN and MMP-3 in ovarian cancer; DMP1 and MMP-9 in lung cancer). 15623631 Human
opn pancreatic ductal adenocarcinomas Recently, high OPN serum levels were found in pancreatic ductal adenocarcinomas (PDACs) in which OPN mRNA was identified in macrophages. 15568158 Human
opn undifferentiated pancreatic carcinomas We investigated OPN expression at the protein level in 15 PDACs and 10 undifferentiated pancreatic carcinomas (UCs), 4 of them with osteoclast-like giant cells (OCGCs), to find out whether the degree of OPN expression is related to tumor infiltration by m 15568158 Human
opn colon cancer While increased OPN expression has been reported in a number of human cancers, and its cognate receptors (alphav-beta3, alphav-beta5, and alphav-beta1 integrins and CD44) have been identified, its role in colon cancer development and progression has not b 15679049 Human
opn colon cancer The current study examined the functional role of OPN in colon cancer progression and metastatic potential. 15679049 Human
opn human colon cancer The principal findings of this study were that both endogenous OPN expression (via stable transfection) as well as exogenous OPN (added to culture medium) enhanced the motility and invasive capacity of human colon cancer cells in vitro. 15679049 Human
opn human colon cancer Stable transfection of four poorly tumorigenic human colon cancer cell lines with OPN also resulted in enhanced tumorigenicity in vivo with increased proliferation and increased CD31 positive microvessel counts, concordant with the degree of OPN expressio 15679049 Human
opn human colon cancer Collectively, these results suggest that OPN may affect multiple functional components contributing to human colon cancer progression and solidifies its role in this process. 15679049 Human
opn necrosis There have been many reports about the severity of hepatic necrosis caused by fulminant hepatitis; however, the relation between proliferated bile ductules and osteopontin (OPN) expression in inflamed areas in each of the clinical forms of fulminant hepat 15712659 Human
opn colon cancer We hypothesized that OPN mediates invasion of colon cancer cells through basement membrane and migration through extracellular matrix (ECM). 15661802 Human
opn choriocarcinoma Three human choriocarcinoma cell lines, namely JAR, BeWo, and JEG-3, were treated with variants of OPN differing in the extent of phosphorylation following sequential dephosphorylation with tartrate-resistant acid phosphatase (TRAP), and their migratory r 15696579 Human
opn metastatic melanoma One of the most abundantly expressed genes in metastatic melanoma nodules is osteopontin (OPN). 15854047 Human
opn crohn's disease BACKGROUND: The aim of the present work was to assess osteopontin (OPN) expression in the colon tissues of ulcerative colitis (UC), Crohn's disease (CD), and diverticulitis (Div) patients. 15868372 Human
opn prostate tumors Studies in vitro suggest that osteopontin (OPN), an extracellular matrix protein secreted by macrophages infiltrating prostate tumors, and by tumor cells, may have a role in the transition from clinically insignificant tumors to metastatic prostate cancer 15867270 Human
opn metastatic prostate cancer Studies in vitro suggest that osteopontin (OPN), an extracellular matrix protein secreted by macrophages infiltrating prostate tumors, and by tumor cells, may have a role in the transition from clinically insignificant tumors to metastatic prostate cancer 15867270 Human
opn tumor OPN stimulates tumor growth, and the levels of c-Jun, AP-1, urokinase type plasminogen activator, and MMP-9 were higher in OPN-induced tumor compared with control. 15757900 Human
opn nasopharyngeal carcinoma AIMS: We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinoma patients. 15922893 Human
opn advanced cancer In addition, high OPN level was found in the patients with advanced cancer and was correlated with neck node metastasis (p<0.05). 15922893 Human
opn hydatidiform moles To analyze the expression of OPN, we performed immunohistochemistry on a total of 27 cases of GTD, including 21 hydatidiform moles and 6 choriocarcinomas, which had previously been characterized with respect to their CEACAM1 expression. 15968204 Human
opn choriocarcinomas To analyze the expression of OPN, we performed immunohistochemistry on a total of 27 cases of GTD, including 21 hydatidiform moles and 6 choriocarcinomas, which had previously been characterized with respect to their CEACAM1 expression. 15968204 Human
opn hydatidiform moles Hydatidiform moles showed a positivity for OPN in villous cytotrophoblast and in the trophoblast proliferations on the villous surface. 15968204 Human
opn choriocarcinomas The strongest OPN expression could be observed in the choriocarcinomas with a heterogenous OPN expression pattern. 15968204 Human
opn granular-cell tumor (gct) For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors. 15998376 Human
opn neuromas In contrast, seven NM and three amputation neuromas were negative for OPN mRNA by either ISH or RT-PCR, while macrophages infiltrated in these tumors had OPN mRNA consistently. 15998376 Human
opn esophageal squamous-cell carcinoma (escc) To evaluate the clinical significance of OPN in esophageal squamous cell carcinoma (ESCC), we compared plasma OPN levels with those of common tumor markers. 16015046 Human
opn common tumor To evaluate the clinical significance of OPN in esophageal squamous cell carcinoma (ESCC), we compared plasma OPN levels with those of common tumor markers. 16015046 Human
opn nsclc Since non-small-cell lung cancer (NSCLC)'s prognosis remains bad, with few predictors of outcome, the purpose of this study was to evaluate if OPN might be involved in NSCLC's biology and therefore represent a prognostic marker and a target for 16091764 Human
opn non-small-cell lung cancer Since non-small-cell lung cancer (NSCLC)'s prognosis remains bad, with few predictors of outcome, the purpose of this study was to evaluate if OPN might be involved in NSCLC's biology and therefore represent a prognostic marker and a target for 16091764 Human
opn stage i nsclc Immunohistochemistry was used to detect OPN expression, evaluated as percentage of neoplastic cells with cytoplasmic immunoreactivity, in a wide cohort of patients with stage I NSCLC (136 cases). 16091764 Human
opn stage i nsclc Our results support the hypothesis that high OPN expression is a significantly unfavourable prognostic factor for the survival of patients with stage I NSCLC. 16091764 Human
opn pancreatic tumors Immunohistochemical analysis demonstrated OPN staining in 60% of the primary pancreatic tumors and in 72% of the lymph node and liver metastases. 15970685 Human
opn head-and-neck cancer BACKGROUND: Osteopontin (OPN) is recognized as a tumor-associated protein and has recently been shown to be a potential plasma marker of tumor hypoxia in head and neck cancer patients. 16024111 Human
opn follicular adenomas RESULTS: In this study we show that OPN is overexpressed in human PTCs with respect to normal thyroid tissue, follicular adenomas, and multinodular goiters (P < 0.05). 15998773 Human
the opn gene metastatic cancer Consequently, the OPN gene was found to be upregulated among various metastatic cancer cells. 14712233 Human
the opn gene metastatic tumor We cloned the OPN promoter, and serial deletion analysis of the OPN promoter showed that the region between -170 and -127 may act as an enhancer to control the OPN gene in metastatic tumor cells. 14712233 Human
the opn gene metastatic tumor Our results suggest that AML-1 and C/EBPalpha play an important role in the upregulation of the OPN gene in metastatic tumor cells. 14712233 Human
opn small cell lung cancer (sclc) OPN was predominantly expressed in tumor cells of non-small cell lung cancer (NSCLC) tissues: 11 of 16 cases (68.8%) of squamous cell carcinoma (SCC), five of 24 cases (20.8%) of adenocarcinoma (AD), but only two of 18 cases (11%) of small cell lung cance 11520606 Human
opn squamous cell carcinoma (scc) OPN was predominantly expressed in tumor cells of non-small cell lung cancer (NSCLC) tissues: 11 of 16 cases (68.8%) of squamous cell carcinoma (SCC), five of 24 cases (20.8%) of adenocarcinoma (AD), but only two of 18 cases (11%) of small cell lung cance 11520606 Human
opn sclc Expectedly, OPN was principally expressed in NSCLC cell lines (H322 cells and HL460 cells) but not in SCLC cell line (H69 cells) by Western blotting and Northern blotting. 11520606 Human
opn sclc Interestingly, Ras-p21 was specifically co-expressed with OPN staining in eight of eight cases with SCC (100%), whereas it was demonstrated in three of ten cases (30%) with AD and only one of 18 cases (5%) with SCLC. 11520606 Human
opn sarcomas The reported association of OPN with malignancy and metastasis prompted us to examine the expression of this protein in seven sarcomas of the pulmonary artery. 11764388 Human
opn sarcomas Although the function of OPN is not yet fully understood, our data indicate that strong expression of this molecule in poorly differentiated sarcomas could play a role in the progression of malignancy and metastasis as described previously for carcinomas. 11764388 Human
opn stage ii breast cancer We now show that a monoclonal antibody to rat OPN recognizes specifically human OPN using Western blotting techniques andused it to assess the prognostic significance of OPN in primary tumors of a group of 333 patients treated between 1976 and 1982 for op 12067984 Human
opn primary colorectal cancer CONCLUSION: The expression of OPN mRNA is the highest in liver metastatic tissues, moderate in primary colorectal cancer tissues, and lowest in adjacent normal tissues of the metastatic liver cancer. 12181091 Human
opn osteosarcoma In this study we determined the expression of OPN in benign and malignant bone tumors and investigated the prognostic influence of OPN expression on the outcome of osteosarcoma patients. 12404059 Human
opn osteosarcoma Although OPN expression correlates with VEGF expression in osteosarcomas, OPN expression does not provide predictive information about the outcome of osteosarcoma patients. 12404059 Human
opn osteosarcomas Although OPN expression correlates with VEGF expression in osteosarcomas, OPN expression does not provide predictive information about the outcome of osteosarcoma patients. 12404059 Human
opn mec These results suggest that induction of MEC migration by OPN involves a cascade of events including at least two growth factor/receptor pathways and multiple downstream signal transduction pathways. 12606946 Human
opn hydatidiform mole Our purpose was to determine the expression of OPN mRNA and protein in hydatidiform mole and in normal placenta of comparable gestational age. 12694667 Human
opn hydatidiform mole RESULTS: Our results showed significantly lower expression of OPN mRNA and protein in hydatidiform mole, and in particular complete mole (P = 0.001 by real-time PCR and P < 0.001 by immunohistochemistry) as compared to nermal placenta. 12694667 Human
opn liver cancer [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells] OBJECTIVE: To investigate the effect of epidermal growth factor (EGF) on the expression of osteopontin (OPN) in liver cancer HepG2 cells. 14703434 Human
opn liver cancer It is possible to block the synthesis of OPN through manipulating several target genes, thus inhibiting the metastasis of liver cancer. 14703434 Human
opn renal cell carcinomas RESULTS: High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometri 14734468 Human
opn fibroblastic osteosarcoma RESULTS: In tumor cells, the high expression rates of BSP, OPN (30.0%,10.0%, respectively) in fibroblastic osteosarcoma were significantly lower than those of osteoblastic group (75.0%,64.3%, respectively). 14994076 Human
opn mammary tumors The size of TM6 tumors in the supplemented group was smaller (mean 0.69 cm2) than in the mice fed with the basal diet (mean 0.93 cm2). cDNA array analysis showed a reduced expression of osteopontin (OPN) in mammary tumors of mice fed with the 3 ppm seleni 15318939 Mouse
opn colon cancer This study demonstrates that RNA interference stably reduces CT26 tumor expression of OPN and significantly attenuates CT26 colon cancer metastasis by diminishing tumor cell motility and invasiveness. 15661802 Mouse
opn idiopathic pulmonary fibrosis (ipf) Osteopontin (OPN) produced by alveolar macrophages functions as a fibrogenic cytokine in the development of bleomycin (BLM)-induced murine pulmonary fibrosis, and OPN mRNA is expressed on lung tissues from patients with idiopathic pulmonary fibrosis (IPF) 15672859 Human
opn cml This may not only prove important in understanding the mechanisms of progression of CML but also highlights a pathway that may prove significant in many other cases of oncogenesis, where OPN expression is implicated. 15857938 Human
opn cml Most importantly, a significant increase of OPN concentration was observed in the serum of CML patients as compared to controls. 15993098 Human
opn cml Overall these results show that OPN is deregulated by BCR-ABL oncogene and suggest that OPN could be involved in CML stem cell biology. 15993098 Human
opn granular cell tumor (gct) For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors. 15998376 Human
opn head and neck cancers Osteopontin (OPN) is a secreted phosphoglycoprotein that has been linked to tumor progression and survival in several solid tumors, including head and neck cancers. 16007184 Human
opn head and neck cancer Previous studies showed that OPN expression is induced by tumor hypoxia, and its plasma levels can serve as a surrogate marker for tumor hypoxia and treatment outcome in head and neck cancer patients. 16007184 Human
opn head and neck squamous cell carcinoma We found that OPN is induced in head and neck squamous cell carcinoma (HNSCC) cell lines and in NIH3T3 cells by hypoxia at both mRNA and protein levels in a time-dependent manner. 16007184 Human
opn esophageal squamous cell carcinoma (escc) To evaluate the clinical significance of OPN in esophageal squamous cell carcinoma (ESCC), we compared plasma OPN levels with those of common tumor markers. 16015046 Human
opn crohn's disease Recently, OPN plasma levels have been demonstrated to be elevated in patients with Crohn's disease. 16917234 Human
opn inflammatory bowel disease OPN may represent a novel attractive target for pharmacological treatment of inflammatory bowel disease. 16917234 Mouse
opn mouse tumour CONCLUSION: Clear strain and tumour specific differences in the effect of hypoxia on OPN levels have been observed in two different mouse tumour models. 16920210 Mouse
eta-1 crohn's disease Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response. 16099792 Human
opn oral squamous cell carcinoma (oscc) The objectives of this study were to assess the immunolocalization of human osteopontin (OPN) in oral lesions and to identify human cell lines of oral squamous cell carcinoma (OSCC) origin that express OPN mRNA. 10069535 Human
opn in situ carcinoma In general, BSP and OPN transcripts were detected in both invasive and in situ carcinoma components. 10418827 Human
opn lymph node metastasis On the other hand, co-expression of osteopontin (OPN) and CD44v9 in tumor cells correlates well with the degree of lyiphatic vessel invasion or long distant lymph node metastasis in diffuse type gastric carcinoma, indicating that mutual interaction betwee 11217448 Human
opn murine mammary tumors Immunochemical analysis of murine mammary tumors shows no co-localization of OPN with the extracellular matrix, identified by laminin staining. 11741994 Mouse
opn hepatic granuloma We analyzed the role of OPN in a beta-glucan-induced hepatic granuloma model. 14978021 Human
opn hepatic granulomas First, we found that neither OPN deficiency nor overexpression of OPN affected the number and the size of hepatic granulomas at day 7, indicating that OPN is not involved in the formation of hepatic granulomas at the early stages. 14978021 Mouse
opn hepatic granulomas Third, at late stages, OPN deficiency resulted in a decrease in the number and size of hepatic granulomas, and a reduction of liver tissue injury. 14978021 Mouse
opn hepatic granuloma These data suggest that OPN affects the persistence of hepatic granuloma formation. 14978021 Mouse
opn lymph node metastasis Negative expression of OPN protein was significantly related to lymphatic permeation, perineural invasion, intrahepatic metastasis, and lymph node metastasis (P=0.0029, 0.0072, 0.0134, and 0.0101, respectively). 15101999 Human
opn murine colon adenocarcinoma In this study, we used CT26 murine colon adenocarcinoma cells syngeneic to BALB/c mice to generate cell lines (pS-OPN) in which OPN expression was suppressed through small interfering RNA (siRNA) plasmids. 15661802 Human
opn lymph node metastasis OPN expression was correlated with different PTC histological variants, lymph node metastasis, and PTC size. 15998773 Human
opn lymph node metastasis High OPN level was associated with lymph node metastasis (p = 0.05), but not with tumor histology or depth of invasion. 16015046 Human
opn clear cell renal cell carcinomas The aim of this study was to analyze the expression of OPN in normal renal tissue and clear cell renal cell carcinomas (CRCCs), and to assess its prognostic significance. 16917865 Human
spp1 follicular thyroid carcinoma Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
spp1 ovarian carcinomas The top 20 differentially expressed genes included 10 genes (Spp1, Cyp1b1, Btg1, Cfh, Mt1, Mt2, Igfbp5, Gstm1, Gstm2, and Esr1) implicated in various aspects of ovarian carcinomas, and other 3 genes (Gsto1, Lcn7, and Alcam) associated to breast cancer. 16245302 Mouse
spp1 cervical cancer Immunohistochemical staining of cancer specimens further confirmed differential expression of SPP1 in cervical cancer cells vs. nontumor cells. 16353136 Human
opn head and neck cancer BACKGROUND: Osteopontin (OPN) is recognized as a tumor-associated protein and has recently been shown to be a potential plasma marker of tumor hypoxia in head and neck cancer patients. 16024111 Human
opn ovarian cancers In ovarian cancers that lacked CA125, all specimens (100%) expressed human kallikrein 10 (HK10), human kallikrein 6 (HK6), osteopontin (OPN), and claudin 3. 16061277 Human
opn oral squamous-cell carcinoma This study investigated the expression pattern of OPN during development of oral squamous-cell carcinoma by using 7,12-dimethylbenz[a]anthracene (DMBA)-induced squamous-cell carcinomas in buccal pouch of syrian golden hamsters. 16095557 Human
opn oral cancer To summarize, our results suggest that buccal-pouch carcinogenesis of Syrian golden hamster may constitute an excellent experimental model to study the mechanisms by which OPN is associated with oral cancer pathogenesis, and to validate OPN-based therapeu 16095557 Human
opn human prostate cancer Recent studies have demonstrated that two SIBLING family members, bone sialoprotein (BSP) and osteopontin (OPN), are overexpressed in human prostate cancer. 16108038 Human
opn nhl However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. 16177564 Human
opn nhl In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia (MC) syndrome and B-cell NHL. 16177564 Human
opn nhl Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. 16177564 Human
opn nhl Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. 16177564 Human
opn follicular thyroid carcinoma Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
opn soft tissue tumors In a series of 15 patients with adult soft tissue tumors, we found that mRNA levels of OPN (p=0.015), Met (p=0.03) and HGF (p<0.001) were significantly higher in tumor tissues relative to paired normal tissues. 16258259 Human
opn adult soft tissue sarcomas This study, which is the first to examine coexpression of these two markers, suggests that OPN may have potential as a prognostic marker in adult soft tissue sarcomas, and further that OPN+/-Met signaling pathways may contribute to their biological behavi 16258259 Human
opn adenoid cystic carcinoma (acc) This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA). 16321564 Human
opn pleomorphic adenoma (pa) This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA). 16321564 Human
opn salivary gland tumour This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA). 16321564 Human
opn salivary gland tumours The results of this study indicate that OPN expression is present in normal salivary gland tissue, and is increased in certain salivary gland tumours, but further investigation is necessary to clarify its role. 16321564 Human
opn prostate cancer To test the hypothesis that expression of osteopontin (OPN), an integrin-binding glycoprotein, can independently predict the potential aggressiveness of prostate cancer, the status of OPN expression in benign and malignant prostate cancer cell lines and t 16331611 Human
opn benign prostate hyperplasia (bph) When the level of OPN in normal tissue was set at 1, its level in benign prostate hyperplasia (BPH) was similar at 0.99 +/- 0.2, whereas the OPN level in the highly malignant carcinoma tissue was greatly increased by nearly 6-fold to 5.9 +/- 0.3. 16331611 Human
opn bph These results showed that the level of OPN expressed between the normal and the BPH samples was not significantly different (Fisher's exact test, p = 0.16). 16331611 Human
opn bph However, in comparison to that in the BPH samples, the expression of OPN in the carcinoma tissues was significantly increased (Chi-square test, p < 0.0001). 16331611 Human
opn gestational trophoblastic tumors Recently we showed the expression pattern of OPN in gestational trophoblastic tumors. 16633066 Human
opn clear cell carcinomas In this study, immunohistochemistry and immunofluorescence with specific antibodies were performed on a series of 20 normal endometrial samples, 17 endometrial hyperplasias, and 43 endometrial carcinomas (28 endometrioid, 10 serous, and 5 clear cell carci 16633066 Human
opn endometrial carcinomas In this study, immunohistochemistry and immunofluorescence with specific antibodies were performed on a series of 20 normal endometrial samples, 17 endometrial hyperplasias, and 43 endometrial carcinomas (28 endometrioid, 10 serous, and 5 clear cell carci 16633066 Human
opn endometrial hyperplasias In this study, immunohistochemistry and immunofluorescence with specific antibodies were performed on a series of 20 normal endometrial samples, 17 endometrial hyperplasias, and 43 endometrial carcinomas (28 endometrioid, 10 serous, and 5 clear cell carci 16633066 Human
opn endometrial carcinomas Strong expression of OPN could be observed in 29 (67.4%) of the 43 analyzed endometrial carcinomas. 16633066 Human
opn endometrioid carcinoma In endometrioid carcinoma with increasing malignancy grade, increasing areas with low OPN expression level or complete loss of OPN expression could be observed. 16633066 Human
opn endometrial tumors In this study, the different expression patterns of OPN in endometrial tumors could additionally support the biological diversity of endometrioid and serous carcinomas together with other markers. 16633066 Human
opn serous carcinomas In this study, the different expression patterns of OPN in endometrial tumors could additionally support the biological diversity of endometrioid and serous carcinomas together with other markers. 16633066 Human
opn endometrial cancer We suggest that OPN might play a different role in the pathogenesis of endometrial cancer (possibly as a functional complex with CEACAM1) and could be relevant for invasive growth of such lesions. 16633066 Human
opn cancers Osteopontin (OPN) is a sialic acid-rich phosphoprotein secreted by a wide variety of cancers. 16670084 Human
opn colorectal cancer We have shown previously that OPN is necessary for mediating hepatic metastasis in CT26 colorectal cancer cells. 16670084 Human
opn hepatic metastasis We have shown previously that OPN is necessary for mediating hepatic metastasis in CT26 colorectal cancer cells. 16670084 Human
opn colorectal cancer Although a variety of stimuli can induce OPN, the molecular mechanisms that regulate OPN gene transcription in colorectal cancer are unknown. 16670084 Human
opn cancer OPN transcription was analyzed in CT26 cancer cells and compared with YAMC (young adult mouse colon) epithelial cells. 16670084 Human
opn colorectal cancer Ets-1 and Runx2 are critical transcriptional regulators of OPN expression in CT26 colorectal cancer cells. 16670084 Mouse
opn metastasis Suppression of these transcription factors results in significant down-regulation of the OPN metastasis protein. 16670084 Human
opn endometrial cancer This study compared the DNA, RNA, and protein levels of osteopontin (OPN) in endometrioid endometrial cancer (EEC) and ovarian endometrioid cancer (OEC). 16720920 Human
opn ovarian endometrioid cancer This study compared the DNA, RNA, and protein levels of osteopontin (OPN) in endometrioid endometrial cancer (EEC) and ovarian endometrioid cancer (OEC). 16720920 Human
opn ovarian cancer We evaluated the preoperative plasma OPN level as a diagnostic biomarker for ovarian cancer in comparison with CA125. 16764622 Human
opn benign ovarian tumor Methods: Preoperative plasma OPN and CA125 levels were measured and compared in 32 patients with ovarian cancer, 34 patients with benign ovarian tumor, 30 patients with other gynecologic cancers and 31 healthy women. 16764622 Human
opn gynecologic cancers Methods: Preoperative plasma OPN and CA125 levels were measured and compared in 32 patients with ovarian cancer, 34 patients with benign ovarian tumor, 30 patients with other gynecologic cancers and 31 healthy women. 16764622 Human
opn ovarian cancer Methods: Preoperative plasma OPN and CA125 levels were measured and compared in 32 patients with ovarian cancer, 34 patients with benign ovarian tumor, 30 patients with other gynecologic cancers and 31 healthy women. 16764622 Human
opn ovarian cancer The sensitivity and specificity for predicting ovarian cancer was compared between OPN and CA125. 16764622 Human
opn benign ovarian tumor Results: Preoperative plasma OPN levels were significantly higher in patients with ovarian cancer than in those with benign ovarian tumor, in other gynecologic patients or in healthy women. 16764622 Human
opn ovarian cancer Results: Preoperative plasma OPN levels were significantly higher in patients with ovarian cancer than in those with benign ovarian tumor, in other gynecologic patients or in healthy women. 16764622 Human
opn ovarian cancer Stage IV ovarian cancer patients and ovarian cancer patients with ascites had higher plasma OPN levels than those without ascites and in a lower stage. 16764622 Human
opn stage iv ovarian cancer Stage IV ovarian cancer patients and ovarian cancer patients with ascites had higher plasma OPN levels than those without ascites and in a lower stage. 16764622 Human
opn ovarian cancer The sensitivity of preoperative plasma OPN in detecting ovarian cancer was 81.3% and almost reached that of CA125. 16764622 Human
opn ovarian cancer Conclusion: Preoperative OPN is a useful biomarker for predicting ovarian cancer. 16764622 Human
opn breast cancer Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. 16807238 Human
opn metastasis Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. 16807238 Human
opn tumor Research concerning how OPN functions in tumor progression has led to the identification of a limited number of genes that contribute functionally to OPN-induced cellular behaviors. 16807238 Human
opn breast cancer Recent microarray analysis, comparing 21NT breast cancer cells transfected to constitutively overexpress OPN with control cells, revealed hyaluronan synthase 2 (HAS2) to be a gene highly up-regulated in OPN-overexpressing cells. 16807238 Human
opn breast cancer To our knowledge, this is the first report of the ability of OPN to regulate HAS2 expression and HA production in breast cancer cells and further illustrates a unique functional relationship by which enhanced HA production facilitates OPN-mediated cell be 16807238 Human
spp1 lymph node metastases Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
opn lymph node metastases Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
opn polymorphous low grade adenocarcinoma (plga) This study examines by immunohistochemistry the expression of OPN in normal salivary gland tissue and three types of salivary gland tumour: pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and polymorphous low grade adenocarcinoma (PLGA). 16321564 Human
opn murine mammary cancer In this study, using metastatic 4T1 and non-metastatic 4T07 murine mammary cancer cell lines, we demonstrate that 4T1 cells exhibit significantly increased OPN, integrin-linked kinase (ILK), matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminoge 16474180 Mouse
opn murine mammary cancer In 4T1 murine mammary cancer cells, we conclude that OPN mediates metastatic behavior, in part, through upregulation of MMP-2 and uPA protein expression. 16474180 Mouse
opn lymph node metastasis The purpose of this study is to investigate the clinical significance of OPN expression in metastatic lymph node of uterine cervical cancers, since the prognosis of the patients with lymph node metastasis is extremely poor. 16675104 Human
opn lymph node metastasis This indicates that OPN may contribute to lymph node metastasis and its advancement, and that the OPN level in metastatic lesion may be a prognostic indicator in uterine cervical cancers. 16675104 Human
opn lymph node metastasis All the 80 ESC patients were positive for OPN expression, and OPN expression levels were correlated with the differentiation (chi(2)=10.766, P<0.05) and lymph node metastasis of the tumor (r(s)=-2.289, P<0.05), but not with the tumor diameter or TNM grade 17121713 Human
opn lymph node metastasis CONCLUSION: The expressions of RhoC and OPN protein are closely related to lymph node metastasis of ESC and the patients survival time, and therefore may serve the purpose of prognostic evaluation of ESC. 17121713 Human
opn meningiomas The present result suggests that OPN produced by CD68-positive macrophages may play a significant role for development of psammoma bodies in meningiomas. 7666059 Human
opn brain tumors This study demonstrates the expression of OPN in human glioma representative of brain tumors. 7837791 Human
opn astrocytomas Expression of OPN mRNA was high in malignant astrocytomas, but low in benign astrocytomas and non-neoplastic tissue. 7837791 Human
opn malignant astrocytomas Expression of OPN mRNA was high in malignant astrocytomas, but low in benign astrocytomas and non-neoplastic tissue. 7837791 Human
opn invasive breast carcinoma Interestingly, the majority of both in situ and invasive breast carcinoma lesions showed a strong expression (2+ or 3+) for OSN or OPN (74.5 and 84.3%, respectively). 7856741 Human
opn mammary cancers This study is the first extensive study of OSN and OPN expression in mammary cancers. 7856741 Human
opn lung tumors This caused a reduction in their OPN secretion and reduced their ability to form both lung tumors in nude mice after intravenous injection, and colonies in soft agar. 8036014 Mouse
opn metastatic carcinoma Moreover, increased levels of OPN have been detected in the blood of patients with metastatic carcinoma. 8080043 Human
opn common tumors To investigate OPN expression and distribution in human carcinomas directly, we studied a wide variety of common tumors by Northern analysis, in situ hybridization, and immunohistochemistry. 8080043 Human
opn tumor necrosis The presence of OPN mRNA in macrophages was particularly pronounced at the edge of tumors (ie, the tumor/stroma interface) and in areas of tumor necrosis. 8080043 Human
opn histiocytic lymphoma Sensitivity of GCT cells to bone peptides was specific, since BALB/3T3 fibroblasts and U-937 histiocytic lymphoma cells with monocytic phenotype failed to respond to BSP-II and OPN fragments. 8238481 Human
opn malignant transformation Osteopontin (OPN), a secreted acidic phosphoglycoprotein found in many tissues and body fluids, is produced in increased amounts in response to certain infections and after malignant transformation. 8830797 Human
opn mastocytoma OPN also inhibited the cytolytic activity of the activated macrophages toward NO-sensitive P815 mastocytoma cells, an action that was blocked by the NO synthase inhibitor, NG-monomethyl-L-arginine. 8830797 Human
opn b16 melanoma We compared the ability of two murine cell lines, L929 fibroblastic cells and B16-BL6 melanoma cells, to interact with OPN (from human milk, and recombinant human and mouse OPN) as well as recombinant OPN prepared to include either the N-terminal or C-ter 8836881 Human
opn resected lung cancers The aims of this study were to determine if OPN was expressed in a series of surgically resected lung cancers, and if there was a relationship between OPN expression and clinico-pathologic findings or outcome. 8959677 Human
opn lung tumors These findings suggest that OPN levels in lung tumors have the potential to provide clinically important predictive information on patient outcome, and that OPN may play a role in the biology of lung cancer. 8959677 Human
opn lung cancer These findings suggest that OPN levels in lung tumors have the potential to provide clinically important predictive information on patient outcome, and that OPN may play a role in the biology of lung cancer. 8959677 Human
opn invasive mammary carcinomas OBJECTIVE: To examine the association between expression of osteopontin (OPN), p53, other molecular markers (Ki-67, c-erb B2, and estrogen receptor protein) and tumor progression in a case of synchronous, bilateral, invasive mammary carcinomas of the same 9199622 Human
opn granuloma annulare In this study, we examined expression of OPN in 22 cases of granulomatous inflammation including cases of sarcoidosis, granulomatous temporal arteritis, histoplasmosis, rheumatoid nodule, granuloma annulare, erythema nodosum, granulomatous gastritis, fore 9251683 Human
opn mammary tumors In mammary tumors arising spontaneously in transgenic mice expressing the oncogenes c-myc and/or v-Ha-ras under the control of the mouse mammary tumor virus promoter, the level of OPN expression is increased dramatically over that in the normal gland in t 9342184 Mouse
opn brain tumor Using a number of different brain tumor-derived cell lines we have demonstrated that the mRNA for osteopontin (OPN), which is substantially over-expressed by some tumors in comparison with normal tissues, is preferentially expressed in high grade and meta 9615723 Human
opn brain tumors Using a number of different brain tumor-derived cell lines we have demonstrated that the mRNA for osteopontin (OPN), which is substantially over-expressed by some tumors in comparison with normal tissues, is preferentially expressed in high grade and meta 9615723 Human
opn metastatic brain tumors Using a number of different brain tumor-derived cell lines we have demonstrated that the mRNA for osteopontin (OPN), which is substantially over-expressed by some tumors in comparison with normal tissues, is preferentially expressed in high grade and meta 9615723 Human
opn malignant gliomas Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas. 9615723 Human
opn breast cancer metastasis These cells provide a useful model for studying molecular mechanisms important for breast cancer metastasis to bone and, in particular, the implication(s) of OPN and VIM expression in this process. 9637769 Human
opn giant cell tumour We show that osteopontin (OPN), bone sialoprotein (BSP) and GRGDSP peptides, in solution, induce activation of metalloproteinase-2 (MMP-2) secreted by human GCT23 giant cell tumour cells. 9639398 Human
opn metastatic tumors Osteopontin (OPN) is a secreted, integrin-binding phosphoprotein that has been implicated in both normal and pathological processes; qualitative increases in OPN blood levels have been reported in a small number of patients with metastatic tumors of vario 9815727 Human
opn metastatic disease The median plasma OPN of patients with metastatic disease was 142 microgram/liter (range, 38-1312 microgram/liter) and was significantly different (P < 0.0001, Mann Whitney U test) from both control groups (medians, 60 and 47 microgram/liter; ranges, 15-1 9815727 Human
opn metastatic breast cancer This study demonstrates a statistically significant elevation in plasma OPN in the majority ( approximately 70%) of a large series of patients with metastatic breast cancer when compared (95th percentile) to healthy women or patients who had completed adj 9815727 Human
opn metastatic breast cancer Furthermore, this is the first study to demonstrate that higher OPN levels in patients with metastatic breast cancer may be associated with an increased number of involved sites and decreased survival. 9815727 Human
opn cutaneous squamous cell carcinoma To delineate the role of OPN during tumor progression, we have subjected OPN null mutant mice to repeated applications of a mutagen/carcinogen to induce cutaneous squamous cell carcinoma. 9823334 Human
opn ovarian tumors Expression of osteopontin (OPN) by ovarian tumors is not known. 9824103 Human
opn adenocarcinomas Tissues from primary ovarian tumors and their metastases from 30 patients (16 LMPs and 14 adenocarcinomas) were evaluated for OPN expression by immunohistochemistry, Western blotting, and in situ hybridization. 9824103 Human
opn ovarian tumors Tissues from primary ovarian tumors and their metastases from 30 patients (16 LMPs and 14 adenocarcinomas) were evaluated for OPN expression by immunohistochemistry, Western blotting, and in situ hybridization. 9824103 Human
opn ovarian adenocarcinomas OPN was weak or absent in 93% of ovarian adenocarcinomas or their metastases. 9824103 Human
opn ovarian neoplasms Expression of OPN primarily by ovarian neoplasms with favorable prognosis is an intriguing new finding of potential importance in the pathogenesis of ovarian LMPs. 9824103 Human
opn meningiomas Recently we reported that osteopontin (OPN) appears to play an important role in the development of psammoma bodies in meningiomas. 9870857 Human
opn meningioma Because the morphology and components of psammoma bodies in papillary carcinoma of the thyroid are similar to those of psammoma bodies in meningioma, we examined whether OPN was related to the psammoma bodies in papillary carcinoma of the thyroid. 9870857 Human
opn adenocarcinoma The present study investigates the presence of OPN in adenocarcinoma of the human prostate and in benign prostatic hyperplasia (BPH). 10529666 Human
opn benign prostatic hyperplasia (bph) The present study investigates the presence of OPN in adenocarcinoma of the human prostate and in benign prostatic hyperplasia (BPH). 10529666 Human
opn bph In BPH specimens, 66.7% of the cases displayed positive staining of OPN. 10529666 Human
opn colonic adenocarcinoma Neither the human embryonic kidney 293 cell line, which expresses the alphavbeta1 integrin, nor the human colonic adenocarcinoma HT-29 cell line, which expresses the alphavbeta5 integrin, were able to adhere to OPN; both of these cell lines are deficient 10535747 Human
opn lymph node metastasis CONCLUSIONS: OPN over-expression was closely related to capsular infiltration, venous invasion, lymph node metastasis, and also with worse prognosis, suggesting that OPN might be deemed as a useful molecular marker for predicting the prognosis of HCC. 17161983 Human
spp1 ptc Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
spp1 carcinogenesis The candidate genes of fibrosis were Spp1, Ctgf, and Cyp2c39 and moreover Cidec and Spp1 were regarded as the candidate genes of carcinogenesis. 16490391 Mouse
spp1 osteosarcoma Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. 17022822 Human
spp1 osteosarcoma RESULTS: THBS3, SPARC and SPP1 were identified as genes differentially expressed in osteosarcoma. 17022822 Human
spp1 osteosarcomas Overexpression of SPP1 was found in 47 of 53 (89%) osteosarcomas correlating with better overall survival, event-free survival and relapse free survival at diagnosis. 17022822 Human
opn tumorigenesis The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. 9892210 Human
opn malignant transformation OPN has been associated with malignant transformation as well as being ligand to the CD44 receptor. 10473115 Human
opn adenocarcinoma To clarify the cooperative role of VEGF and OPN in tumor angiogenesis, we stained VEGF, OPN, and CD34 immunohistochemically in 87 cases of stage I non-small cell lung cancer (adenocarcinoma, 55, and squamous cell carcinoma, 32). 10508818 Human
opn adenocarcinomas VEGF was found in 34 of 55 cases of adenocarcinomas and 14 of 32 squamous cell carcinomas, and OPN was found in 30 of 55 adenocarcinomas and 10 of 32 squamous cell carcinomas. 10508818 Human
opn adenocarcinoma In adenocarcinoma, microvessel counts of VEGF-positive and OPN-positive tumors were significantly higher than VEGF-negative and OPN-negative tumors, respectively, whereas in squamous cell carcinoma they were not. 10508818 Human
opn stage i lung adenocarcinoma More importantly, patients with VEGF- and OPN-positive stage I lung adenocarcinoma had significantly worse prognosis as compared with other groups. 10508818 Human
opn murine erythroleukemia Recombinant OPN and BSP can protect murine erythroleukemia cells from attack by human complement as well as human MCF-7 breast cancer cells and U-266 myeloma cells from attack by guinea pig complement. 10747989 Mouse
opn myeloma Recombinant OPN and BSP can protect murine erythroleukemia cells from attack by human complement as well as human MCF-7 breast cancer cells and U-266 myeloma cells from attack by guinea pig complement. 10747989 Human
opn pulmonary granuloma The OPN-containing vector, but not the control vector, induced pulmonary granuloma formation. 10832978 others
opn mec This study examines the mechanism of OPN-induced MEC migration, in terms of the cell surface integrins involved and induction of the HGF/Met pathway. 10861844 Human
opn mec OPN-induced cell migration is thus mediated by different cell surface integrins in MEC lines representing different stages of progression, and involves activation of the HGF receptor, Met. 10861844 Human
opn malignant transformation Since its initial description in 1979 as a secreted protein associated with malignant transformation, Opn has been independently discovered by investigators from diverse scientific disciplines, and has been associated with a remarkable range of pathologic 11298186 Human
opn adenocarcinoma OPN was predominantly expressed in tumor cells of non-small cell lung cancer (NSCLC) tissues: 11 of 16 cases (68.8%) of squamous cell carcinoma (SCC), five of 24 cases (20.8%) of adenocarcinoma (AD), but only two of 18 cases (11%) of small cell lung cance 11520606 Human
opn malignant transformation The TP53-directed regulation of OPN expression suggests a novel model of TP53 participation in immunosurveillance, involving interaction with the host immune system to prevent damaged cells from undergoing malignant transformation. 11807984 Mouse
opn carcinogenesis BACKGROUND AND AIMS: The expression of osteopontin (OPN), a protein postulated to play a role in tumorigenesis, is induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo and in the in vitro initiation-promotion skin carcinogenes 12009309 Human
opn primary tumors We now show that a monoclonal antibody to rat OPN recognizes specifically human OPN using Western blotting techniques andused it to assess the prognostic significance of OPN in primary tumors of a group of 333 patients treated between 1976 and 1982 for op 12067984 Human
opn mec We previously showed that OPN-induced cell migration of mammary epithelial cells (MEC) depends on binding to cell surface integrins and involves activation of the hepatocyte growth factor (HGF) receptor, Met. 12606946 Human
opn mec Here, we show that OPN-induced migration of MEC also requires activation of the epidermal growth factor (EGF) pathway. 12606946 Human
opn tumorigenesis In addition to already known tumor-associated genes, the majority of identified genes have not yet been brought into context with tumorigenesis such as genes involved in bone matrix mineralization (OSN, OPN, and OSF-2) in lung, breast, and kidney cancer o 14871811 Human
opn hyperplasia Histologic assessment of arthritic joints from OPN-deficient mice revealed synovial hyperplasia, pannus formation, mononuclear cell infiltration, bone erosion, cartilage damage at sites adjacent to and distal from pannus invasion, and tartrate-resistant a 15334485 Mouse
opn hcc This study aimed to elucidate the interaction of the frequent aberrant mRNA expression of alpha-fetoprotein (AFP), osteopontin (OPN) and a novel short isoform of annexin A10 (ANXA10S) at 4q in the tumor progression among 294 patients who received surgical 15754002 Human
opn hcc In conclusion, the aberrant expressions of AFP, OPN and ANXA10S cooperatively contribute to tumor progression and poor prognosis, and are useful for molecular staging of HCC and the subclassification of stage II HCC without vascular invasion. 15754002 Human
opn solid tumors Osteopontin (OPN) expression has been shown to be involved in the progression and increased aggression and invasiveness of many solid tumors. 15857938 Human
opn leukemia Here, we demonstrate that OPN expression is induced in a model of leukemia, and we describe the identification of specific signaling pathways required for the induction of OPN expression by p210 Bcr-Abl. 15857938 Human
opn npc RESULTS: The mean plasma OPN level was significantly higher in NPC patients than in normal controls (184.66 vs 75.89 ng/ml, p<0.001). 15922893 Human
opn npc CONCLUSIONS: Our findings indicated a potential role of OPN in the pathogenesis and nodal metastasis of undifferentiated NPC. 15922893 Human
opn neurilemmomas Immunohistochemistry by anti-OPN-monoclonal antibody revealed OPN-immunoreactivity in tumor cells of all GCT and stromal macrophages in neurilemmomas and one MPNST, but neither in amputation neuromas nor in granular cell epulides. 15998376 Human
opn neuromas Immunohistochemistry by anti-OPN-monoclonal antibody revealed OPN-immunoreactivity in tumor cells of all GCT and stromal macrophages in neurilemmomas and one MPNST, but neither in amputation neuromas nor in granular cell epulides. 15998376 Human
opn mpnst Immunohistochemistry by anti-OPN-monoclonal antibody revealed OPN-immunoreactivity in tumor cells of all GCT and stromal macrophages in neurilemmomas and one MPNST, but neither in amputation neuromas nor in granular cell epulides. 15998376 Human
opn solid tumors Osteopontin (OPN) is a secreted phosphoglycoprotein that has been linked to tumor progression and survival in several solid tumors, including head and neck cancers. 16007184 Human
opn hnscc We found that OPN is induced in head and neck squamous cell carcinoma (HNSCC) cell lines and in NIH3T3 cells by hypoxia at both mRNA and protein levels in a time-dependent manner. 16007184 Human
opn escc METHODS: Preoperative plasma OPN levels were measured by enzyme immunoassay in 103 ESCC patients. 16015046 Human
opn escc CONCLUSION: Measurement of the plasma OPN level, as well as serum SCC antigen and Cyfra 21-1, may help to predict the progression of ESCC. 16015046 Human
opn carcinogenesis To summarize, our results suggest that buccal-pouch carcinogenesis of Syrian golden hamster may constitute an excellent experimental model to study the mechanisms by which OPN is associated with oral cancer pathogenesis, and to validate OPN-based therapeu 16095557 Human
opn lymphomagenesis These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases. 16177564 Human
opn ptc Selected relevant genes (CCL20, CCL2, CXCL8, CXCR4, L-selectin, GM-CSF, IL1B, MMP9, UPA, and SPP1/OPN) were found up-regulated also in clinical samples of PTC, particularly those characterized by RET/PTC activation, local extrathyroid spread, and lymph no 16203990 Human
opn malignant transformation The results in our study support our hypothesis and suggest that the increased OPN level may be involved in the malignant transformation of prostate epithelial cells and OPN expression level is an important determinant for patient survival. 16331611 Human
opn bone metastasis Using a new syngeneic model of bone metastasis (r3T), we examined whether OPN-deficient mice are similarly resistant to bone loss resulting from osteolytic tumor growth. 16436669 Human
opn uterine cervical cancers The purpose of this study is to investigate the clinical significance of OPN expression in metastatic lymph node of uterine cervical cancers, since the prognosis of the patients with lymph node metastasis is extremely poor. 16675104 Human
opn uterine cervical cancers The OPN level was significantly (P<0.05) increased in 25 of 40 metastatic lymph node lesions of uterine cervical cancers. 16675104 Human
opn uterine cervical cancers The prognosis of the 25 patients with significant increase of OPN in uterine cervical cancers was extremely poor, whereas the 24-month survival rate of the 15 patients with no increase of OPN was 67%. 16675104 Human
opn uterine cervical cancers This indicates that OPN may contribute to lymph node metastasis and its advancement, and that the OPN level in metastatic lesion may be a prognostic indicator in uterine cervical cancers. 16675104 Human
opn inflammatory bowel disease To determine the significance of OPN in inflammatory bowel disease, we studied the development of acute, experimental colitis induced by dextran sulfate sodium (DSS) in OPN-null and wild-type (WT) mice. 16741956 Human
opn oncogenic Here we show in a rat mammary model system that wild type (WT) BRCA1 specifically represses the expression of osteopontin (OPN), a multifunctional estrogen-responsive gene implicated in oncogenic transformation, particularly that of the breast. 16807234 Rat
opn familial breast cancer A mutant BRCA1 allele (Mut.BRCA1) associated with familial breast cancer lacks OPN suppressor effects, binds to WT.BRCA1, and impedes WT.BRCA1 suppression of OPN. 16807234 Rat
opn breast tumor Stable transfection of rat breast tumor cell lines with Mut.BRCA1 dramatically up-regulates OPN protein and induces anchorage independent growth. 16807234 Rat
opn human primary breast cancer In human primary breast cancer, BRCA1 mutation is significantly associated with OPN overexpression. 16807234 Rat
opn cancer Taken together, these data suggest that BRCA1 mutation may confer increased tissue-specific cancer risk, in part by disruption of BRCA1 suppression of OPN gene transcription. 16807234 Human
opn tumor We show that 21NT OPN-transfected cells express high levels of HAS2, which is associated with increased HA production and matrix retention and is necessary for tumor cell adhesion to bone marrow endothelial cells and anchorage-independent growth. 16807238 Human
opn breast tumor Thus, in addition to the widely reported roles of OPN in late stages of tumor progression, these results provide functional evidence that OPN contributes to breast tumor growth as well. 16830223 Mouse
opn chronic myeloid leukaemia Overexpression of Opn is a feature of haemopoietic malignancies, such as multiple myeloma and chronic myeloid leukaemia, although its exact role in the aetiology and progression of these diseases remains unclear. 16848793 Human
opn pleural mesothelioma BACKGROUND: The tumor-associated glycoprotein osteopontin (OPN) is discussed as a plasma surrogate marker of tumor hypoxia and as an indicator of the presence of pleural mesothelioma in asbestos-exposed individuals. 16911785 Human
opn head and neck cancer OPN levels in cervix cancer patients were comparable to those of head and neck cancer patients. 16911785 Human
opn cervix cancer OPN levels in cervix cancer patients were comparable to those of head and neck cancer patients. 16911785 Human
opn head-and-neck cancer METHODS AND MATERIALS: Tumor tissue sections of 34 patients with advanced head-and-neck cancer treated with radiotherapy were assessed by immunochemistry for the expression of OPN, HIF-1alpha, and CA IX. 17056190 Human
opn head-and-neck cancer RESULTS: Bivariate analysis showed a significant correlation of positive OPN staining with low hemoglobin level (p = 0.02), high HIF-1alpha expression (p = 0.02), and high serum vascular endothelial growth factor level (p = 0.02) for advanced head-and-nec 17056190 Human
opn cysts METHODS: 60 surgically excised cysts were studied with HE and immunohistochemistry staining by using antibodies specific for OPN. 17094614 Human
opn hydatid cysts RESULTS: Expression of OPN was found at various degree in hydatid cysts, 75% (45/60) was distributed in the intra-layer at the parasite side, 8.3% (5/60) distributed in the extra-layer near the side of liver parenchyma ("exocyst"-layer vs " 17094614 Human
opn hydatid cyst Meanwhile, OPN was concurrently found with the deposit of calcium in a similar distribution in the hydatid cyst. 17094614 Human
opn esophageal squamous carcinoma [Expressions of RhoC and osteopontin in esophageal squamous carcinoma and association with the patients' prognosis] OBJECTIVE: To investigate the expressions of RhoC and osteopontin (OPN) protein in esophageal squamous carcinoma (ESC) and their assoc 17121713 Human
opn esophageal squamous carcinoma (esc) [Expressions of RhoC and osteopontin in esophageal squamous carcinoma and association with the patients' prognosis] OBJECTIVE: To investigate the expressions of RhoC and osteopontin (OPN) protein in esophageal squamous carcinoma (ESC) and their assoc 17121713 Human
opn carcinogenesis Several earlier reports indicated that OPN is associated with various cancers; but its functional role in carcinogenesis is still not well defined. 17168734 Human
opn tongue scc Methods: We selected 46 cases of tongue SCC and investigated the expression of OPN by immunohistochemical staining. 17181739 Human
opn early invasive carcinoma In cases of early invasive carcinoma, in particular, expression of OPN showed a remarkable increase at the invasion front compared with the non-invaded regions. 17181739 Human

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