IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene STAT3 Ensembl ENSG00000168610 Chromosome 17 Start 37718869 End 37794039
Description Signal transducer and activator of transcription 3 (Acute-phase response factor) [Source:UniProtKB/Swiss-Prot;Acc:P40763]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11364
     Entrez Gene : 6774
     UCSC : uc002hzl.1
     GeneCards : 11364
     RefSeq : NM_003150
     CCDS : CCDS32656.1
     Uniprot : P40763
     Interpro : P40763
     OMIM : 102582
     GeneTests : STAT3
     CGAP : STAT3
     PMID : 7512451

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.50 199 1 0.53 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17184 AD c.1204G>T p.G402C Substitution - Missense Heterozygous 17:37735127-3773512718948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  289_at  -0.27  1.71e-3  5.05e-3  -0.49  1.15e-4  4.55e-4
 HG_U95  39708_at  -0.37  2.37e-5  1.13e-4  -0.58  3.99e-7  2.70e-6
 HG_U133A  208991_at  0.21  9.19e-5  1.92e-4  -2.67  2.78e-97  1.75e-96
 HG_U133A  208992_s_at  0.75  9.75e-20  7.49e-19  -3.28  3.08e-100  2.10e-99
 HG_U133_Plus2  208991_at  -0.34  1.02e-5  3.88e-5  -0.32  3.29e-4  6.82e-4
 HG_U133_Plus2  208992_s_at  -0.40  5.62e-4  1.54e-3  -0.54  3.11e-5  7.45e-5
 HG_U133_Plus2  225289_at  0.17  5.58e-2  9.26e-2  0.22  5.62e-2  7.98e-2
 HG_U133_Plus2  235680_at  -0.52  6.00e-4  1.63e-3  -0.99  9.30e-15  7.10e-14
 HG_U133_Plus2  243213_at  0.97  7.13e-6  2.79e-5  1.32  3.91e-9  1.55e-8
 Stanford  17928  0.09  8.00e-1  8.89e-1  -0.62  8.32e-2  2.41e-1
 Stanford  19020  -0.27  4.58e-1  6.47e-1  -0.89  3.77e-2  1.40e-1
 Agilent_HS_21.6K  12170  -0.34  1.26e-7  4.08e-6  -0.37  1.35e-6  2.02e-5
 Agilent_HS_21.6K  17127  -0.16  3.45e-3  2.04e-2  -0.24  2.82e-4  1.90e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208991_at  0.15  4.46e-1  9.14e-1  0.06  6.89e-1  1.00e+0
 HG_U133A  208992_s_at  0.14  5.61e-1  9.43e-1  -0.08  6.46e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 289_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 39708_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208991_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208992_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208991_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208992_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225289_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235680_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243213_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17928    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19020    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12170    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17127    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
stat3 cutaneous t-cell lymphoma In vivo activation of STAT3 in cutaneous T-cell lymphoma. 15141228 Human
stat3 tumor Malignant lymphocytes in dermal infiltrates of CTCL tumors showed frequent and intense nuclear staining with anti-PY-STAT3 antibody, indicating a constitutive activation of STAT3 in vivo in tumor stages. 15141228 Human
stat3 tumors Malignant lymphocytes in dermal infiltrates of CTCL tumors showed frequent and intense nuclear staining with anti-PY-STAT3 antibody, indicating a constitutive activation of STAT3 in vivo in tumor stages. 15141228 Human
stat3 tumor To address the role of STAT3 in survival/apoptosis, CTCL tumor cells from an advanced skin tumor were transfected with either wild-type STAT3 (STAT3wt) or dominant-negative STAT3 (STAT3D). 15141228 Human
stat3 tumors In conclusion, a profound in vivo activation of STAT3 is observed in MF tumors but not in the early stages of MF. 15141228 Human
stat3 tumor Moreover, STAT3 protects tumor cells from apoptosis in vitro. 15141228 Human
stat3 cutaneous t-cell lymphoma Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3. 11807001 Human
stat3 tumor In a previous study, constitutive activation of Stat3 was found in tumor cells isolated from affected skin and blood from CTCL patients. 11807001 Human
stat3 tumor Transfection of tumor cells with dominant-negative Stat3 almost completely blocks IL-5 production and strongly inhibits IL-13 production, whereas IL-6 production is unaffected. 11807001 Human
stat3 tumor The constitutive activation of the Stat3 oncogene product and mutation of the p53 tumor suppressor are both frequently detected in human breast cancer. 11809683 Human
stat3 human breast cancer The constitutive activation of the Stat3 oncogene product and mutation of the p53 tumor suppressor are both frequently detected in human breast cancer. 11809683 Human
stat3 breast cancer We demonstrate that expression of wt p53, but not mutant p53, significantly diminished phosphorylation of Stat3, reduced Stat3 DNA binding activity, and inhibited Stat3-dependent transcriptional activity in breast cancer cells expressing constitutively ac 11809683 Human
stat3 breast cancer Wt p53 also induced significant apoptosis in breast cancer cell lines that express constitutively active Stat3. 11809683 Human
stat3 pancreatic cancer Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. 15015587 Human
stat3 cancers STAT3 is activated constitutively in a number of cancers. 15015587 Human
stat3 pancreatic cancer MATERIALS AND METHODS: This study was conducted to assess the possible involvement of STAT3 activation in pancreatic cancer and the potential for this pathway as a target in chemopreventive strategy. 15015587 Human
stat3 human pancreatic carcinoma RESULTS: STAT3 was shown for the first time to be constitutively activated in human pancreatic carcinoma specimens but not in normal pancreatic tissues. 15015587 Human
stat3 pancreatic tumor Constitutively activated STAT3 was also found in pancreatic tumor cell lines (Panc-1 and MIA PaCa-2) which could be modulated by indole-3-carbinol (13C) and genistein. 15015587 Human
stat3 pancreatic cancer CONCLUSION: Given its critical role in tumorigenesis, our results suggest that STAT3 activation provides an important and appropriate target for chemoprevention in pancreatic cancer treatment. 15015587 Human
stat3 human colorectal carcinoma Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. 15162527 Human
stat3 tumor Constitutive activation of Stat3 has been observed in a growing number of tumor-derived cell lines, as well as tumor specimens from human cancers. 15162527 Human
stat3 cancers Constitutive activation of Stat3 has been observed in a growing number of tumor-derived cell lines, as well as tumor specimens from human cancers. 15162527 Human
stat3 colorectal carcinoma The purpose of this study was to investigate the expression of p-Stat3, activated form of Stat3, and its downstream mediators including cyclin D1 and Bcl-x(L) in colorectal carcinoma (CRC), and to explore the possible mechanism of Stat3 signaling pathway 15162527 Human
stat3 colorectal carcinoma (crc) The purpose of this study was to investigate the expression of p-Stat3, activated form of Stat3, and its downstream mediators including cyclin D1 and Bcl-x(L) in colorectal carcinoma (CRC), and to explore the possible mechanism of Stat3 signaling pathway 15162527 Human
stat3 colorectal carcinoma METHODS: Tissue samples from 45 patients of primary colorectal carcinoma were selected for studying Stat3 signaling pathway protein expression. 15162527 Human
stat3 colorectal carcinoma CONCLUSION: Constitutive activation of Stat3 may play an important role in the tumorigenesis of colorectal carcinoma, and the detailed mechanism of Stat3 signaling pathway in CRC deserves further investigation. 15162527 Human
stat3 human hepatoma Here we demonstrate that long-term (3-6 days) but not short-term (up to 1 day) IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activation of STAT1 (signal transducers and activators of transcription factor 1), STAT2 and STAT3, but e 14690454 Human
stat3 breast carcinoma Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. 15064716 Human
stat3 gastric cancer STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. 15077160 Human
stat3 gastric cancer There are few reports, however, on the role of STAT3 signaling in gastric cancer. 15077160 Human
stat3 gastric cancer The aim of the present study was to clarify the role of STAT3 signaling in apoptosis and cellular proliferation in gastric cancer. 15077160 Human
stat3 human gastric cancer Here we reported that STAT3 was constitutively activated in various human gastric cancer cells and its inhibition by ectopic dominant-negative STAT3 or Janus kinase inhibitor, tyrphostin AG490, induced apoptosis. 15077160 Human
stat3 human gastric cancer Finally, activated form of STAT3, Tyr-705 phospho-stat3, was found in the nucleus of cancer cells in 11 of 40 (27.5%) human gastric cancer specimens. 15077160 Human
stat3 cancer Finally, activated form of STAT3, Tyr-705 phospho-stat3, was found in the nucleus of cancer cells in 11 of 40 (27.5%) human gastric cancer specimens. 15077160 Human
stat3 gastric cancer These findings suggest that constitutively activated STAT3 signaling supports gastric cancer cell survival in association with survivin expression.2004 15077160 Human
stat3 human tumors Cooperation between STAT3 and c-Jun results in suppression of Fas Receptor (FasR) transcription, which is often seen in advanced human tumors. 11733515 Human
stat3 erythroleukemia Constitutive activation of Stat1 and Stat3 in primary erythroleukemia cells. 11843291 Human
stat3 erythroleukemia Previously, we demonstrated that Stat1 and Stat3 are activated by erythropoietin (EPO) in a human EPO-dependent erythroleukemia cell line UT-7/EPO. 11843291 Human
stat3 erythroleukemia We report here that Stat1 and Stat3 are constitutively activated in freshly isolated erythroleukemia cells. 11843291 Human
stat3 erythroleukemia Thus, Stat1 and Stat3 may support cell growth in part via c-myc gene activation in primary erythroleukemia cells. 11843291 Human
stat3 renal cancer STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. 11849447 Human
stat3 renal cancer CONCLUSIONS: This study identified STAT3, but not ERKs, to be a major mediator of IL-6-induced proliferation of renal cancer cells. 11849447 Human
stat3 t-cell lymphomas Furthermore, immunohistochemical studies demonstrate that among distinct human B and T cell lymphomas, activation of Stat3 nuclear translocation is uniquely associated with ALK expression. 11850821 Human
stat3 tumor These studies support a pathogenic mechanism whereby stimulation of anti-apoptotic signals through activation of Stat3 contributes to the successful outgrowth of ALK positive tumor cells. 11850821 Human
stat3 embryonal carcinoma (ec) LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells. 11855863 Human
stat3 leukemia Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3. 11858938 Human
stat3 tumors Because constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been linked to carcinogenesis of various tumors including head and neck SCCa, we studied whether sulindac treatment affects the Stat3 signaling pathway in or 11861373 Human
stat3 prostate cancer These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells. 11751884 Human
stat3 cancer We illustrate this approach using data from our study seeking a molecular fingerprint of STAT3 regulated genes for early detection of human cancer. 11867083 Human
stat3 hepatoma In coimmunoprecipitations, NcoA/SRC1a was found to associate with STAT3 following IL-6 stimulation of HepG2 hepatoma cells. 11773079 Human
stat3 multiple myeloma In multiple myeloma, IL-6 only enhanced the proliferation of CD45+ tumor cells that harbored the IL-6-independent activation of src family kinases even though STAT3 and ERK1/2 could be activated in response to IL-6 in both CD45+ and CD45(minus sign) cells 11877294 Human
stat3 tumor In multiple myeloma, IL-6 only enhanced the proliferation of CD45+ tumor cells that harbored the IL-6-independent activation of src family kinases even though STAT3 and ERK1/2 could be activated in response to IL-6 in both CD45+ and CD45(minus sign) cells 11877294 Human
stat3 myeloma These results indicate that the activation of both STAT3 and ERK1/2 is not enough for IL-6-induced proliferation of myeloma cell lines that require src family kinase activation independent of IL-6 stimulation. 11877294 Human
stat-3 glioma Retinoic acid increases proliferation rate of GL-15 glioma cells, involving activation of STAT-3 transcription factor. 11891779 Human
stat3 primary tumors Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat3 tumor Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat3 cancers Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat3 prostate cancer CONCLUSIONS: We have previously shown that Stat3 is activated in prostate cancer. 11912448 Human
stat3 prostate cancer The results of the current study demonstrate that in addition to Stat3, Stat6 is selectively activated in prostate cancer. 11912448 Human
stat3 head-and-neck cancer The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. 11927016 Human
stat3 acute promyelocytic leukemia Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. 11929748 Human
stat3 invasive breast cancer We have recently demonstrated that sustained activation or hyper-activation of c-Src and Stat3, which occurs in invasive breast cancer, can stimulate strong expression of HGF in carcinoma cells. 11934261 Human
stat3 carcinoma We have recently demonstrated that sustained activation or hyper-activation of c-Src and Stat3, which occurs in invasive breast cancer, can stimulate strong expression of HGF in carcinoma cells. 11934261 Human
stat3 mammary carcinoma Future studies will identify novel Stat3 consensus sites that regulate HGF promoter activity and HGF expression preferentially in carcinoma cells and could lead to novel therapeutic drugs that specifically block HGF expression in mammary carcinoma cells, 11934261 Human
stat3 metastasis Future studies will identify novel Stat3 consensus sites that regulate HGF promoter activity and HGF expression preferentially in carcinoma cells and could lead to novel therapeutic drugs that specifically block HGF expression in mammary carcinoma cells, 11934261 Human
stat3 carcinoma Future studies will identify novel Stat3 consensus sites that regulate HGF promoter activity and HGF expression preferentially in carcinoma cells and could lead to novel therapeutic drugs that specifically block HGF expression in mammary carcinoma cells, 11934261 Human
stat3 cancer In this review, we will: (a) explain the mechanisms of STAT activation in normal and malignant signaling; (b) summarize recent evidence for the critical role of constitutively activated Stat3 and Stat5 in oncogenesis; (c) identify candidate STAT target ge 11948098 Human
stat3 tumor In this review, we will: (a) explain the mechanisms of STAT activation in normal and malignant signaling; (b) summarize recent evidence for the critical role of constitutively activated Stat3 and Stat5 in oncogenesis; (c) identify candidate STAT target ge 11948098 Human
stat3 ovarian cancer To determine the effect of such hormones on the activation of interleukin 6 (IL-6)/STAT3 (signal transducer and activator of transcription-3) signaling, which may be involved in ovarian cancer, we investigated the status of STAT3, IL-6, and its receptor i 11959895 Human
stat3 ovarian cancer Increased IL-6Ralpha expression and constitutive STAT3 activation may be associated with ovarian cancer. 11959895 Human
stat3 tumor angiogenesis Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. 11960372 Human
stat3 cancer While tyrosine kinases signal through multiple pathways, signal transducer and activation of transcription 3 (Stat3) is a point of convergence for many of these and is constitutively activated with high frequency in a wide range of cancer cells. 11960372 Human
stat3 cancer Here, we show that VEGF expression correlates with Stat3 activity in diverse human cancer cell lines. 11960372 Human
stat3 tumor angiogenesis An activated Stat3 mutant (Stat3C) up-regulates VEGF expression and stimulates tumor angiogenesis. 11960372 Human
stat3 tumor Furthermore, interrupting Stat3 signaling with dominant-negative Stat3 protein or Stat3 antisense oligonucleotide in tumor cells down-regulates VEGF expression. 11960372 Human
stat3 cancers These studies provide evidence that the VEGF gene is regulated directly by Stat3 protein, and indicate that Stat3 represents a common molecular target for blocking angiogenesis induced by multiple signaling pathways in human cancers. 11960372 Human
stat3 tumors In this study, we demonstrate that Stat3 is constitutively activated in glioma and medulloblastoma tumors and that the activated protein localizes predominantly to the tumor endothelial cells in the highly vascularized glioma tumors. 11960378 Human
stat3 tumor In this study, we demonstrate that Stat3 is constitutively activated in glioma and medulloblastoma tumors and that the activated protein localizes predominantly to the tumor endothelial cells in the highly vascularized glioma tumors. 11960378 Human
stat3 glioma In this study, we demonstrate that Stat3 is constitutively activated in glioma and medulloblastoma tumors and that the activated protein localizes predominantly to the tumor endothelial cells in the highly vascularized glioma tumors. 11960378 Human
stat3 tumor In the present study, we have investigated the possible role of signal transducers and activators of transcription (STATs), particularly Stat3, in mouse skin tumor promotion and multistage carcinogenesis. 15059889 Mouse
stat3 tumor Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin. 15059889 Mouse
stat3 tumors In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter. 15059889 Mouse
stat3 tumor Several approaches were used to examine the possible role of epidermal growth factor receptor (EGFR) in modulating Stat3 activity during tumor promotion. 15059889 Mouse
stat3 skin papillomas Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3. 15059889 Mouse
stat3 tumor Collectively, the current results suggest that Stat3 activation may be a critical event during mouse skin tumor promotion, possibly through regulation of keratinocyte proliferation. 15059889 Mouse
stat3 tumor In addition, Stat3 activation in tumor promoter-treated epidermis and in skin papillomas may occur, at least in part, via interaction with and phosphorylation by the EGFR. 15059889 Mouse
stat3 skin papillomas In addition, Stat3 activation in tumor promoter-treated epidermis and in skin papillomas may occur, at least in part, via interaction with and phosphorylation by the EGFR. 15059889 Mouse
stat3 epithelial tumors Finally, constitutive activation of Stat3 in both papillomas and squamous cell carcinomas suggest a role in both the development of autonomous growth and the progression of epithelial tumors in mouse skin. 15059889 Mouse
stat3 papillomas Finally, constitutive activation of Stat3 in both papillomas and squamous cell carcinomas suggest a role in both the development of autonomous growth and the progression of epithelial tumors in mouse skin. 15059889 Mouse
stat3 squamous-cell carcinomas Finally, constitutive activation of Stat3 in both papillomas and squamous cell carcinomas suggest a role in both the development of autonomous growth and the progression of epithelial tumors in mouse skin. 15059889 Human
stat3 cancer Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer? 14998485 Human
stat3 tumor Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer? 14998485 Human
stat3 cancer A model of immune evasion mediated by tumors expressing constitutively activated Stat3 was recently proposed in Nature Medicine by Wang et al., suggesting opportunities for a new therapeutic approach for cancer. 14998485 Human
stat3 tumors A model of immune evasion mediated by tumors expressing constitutively activated Stat3 was recently proposed in Nature Medicine by Wang et al., suggesting opportunities for a new therapeutic approach for cancer. 14998485 Human
stat3 myeloma By Western blot analysis, we demonstrated that the intracellular signaling pathways of IL-21 in myeloma cells involved phosphorylation of Jak1, Stat3, and Erk1/2 (p44/42 mitogen-activated protein kinase). 11986233 Human
stat3 myeloma Further analysis showed that BMP-2 induced down-regulation of Bcl-X(L) through the inactivation of STAT3, resulting in the induction of apoptosis in myeloma cells. 12002771 Human
stat3 breast carcinoma Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines. 11859072 Human
stat3 tumor Other signaling molecules, including the estrogen receptor, the tyrosine kinases c-Src and Syk, and STAT proteins, especially STAT3, have also been implicated in BC tumor growth. 11859072 Human
stat-3 tumor Constitutive activation of Stat-3 recently has been observed in many tumor cells, and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. 12015764 Human
stat-3 squamous cell carcinoma of the head and neck In the current study for the first time to the authors's knowledge, the expression of STAT-3 was analyzed in various stages and sites of squamous cell carcinoma of the head and neck (HNSCC). 12015764 Human
stat-3 tumors RESULTS: Overall, 58.9% of HNSCC tumors showed very high Stat-3 protein accumulation, and 23.3% showed intermediate accumulation whereas 17.8% of HNSCC tumors were negative for Stat-3. 12015764 Human
stat-3 solid tumors CONCLUSIONS: Stat-3 activation is an early event in head and neck carcinogenesis though its role in blocking the apoptosis in vivo in solid tumors was not observed. 12015764 Human
stat3 prostatic carcinomas Stat3 activation in prostatic carcinomas. 11987152 Human
stat3 cancers BACKGROUND: Activated Stat3 is found in various types of immortal cell lines and cancers. 11987152 Human
stat3 human prostate cancer We and others have previously demonstrated that Stat3 is constitutively activated in rat and human prostate cancer cell lines, and that Stat3 activation is involved in IL-6-mediated signaling transduction in prostate cancer cells. 11987152 Human
stat3 prostate cancer We and others have previously demonstrated that Stat3 is constitutively activated in rat and human prostate cancer cell lines, and that Stat3 activation is involved in IL-6-mediated signaling transduction in prostate cancer cells. 11987152 Human
stat3 tumors RESULTS: Significantly higher levels of constitutive Stat3 activity were detected in both prostate carcinomas and the matched normal prostate tissues adjacent to tumors compared to the normal prostates from donors without prostate cancer. 11987152 Human
stat3 prostate cancer RESULTS: Significantly higher levels of constitutive Stat3 activity were detected in both prostate carcinomas and the matched normal prostate tissues adjacent to tumors compared to the normal prostates from donors without prostate cancer. 11987152 Human
stat3 prostate carcinomas RESULTS: Significantly higher levels of constitutive Stat3 activity were detected in both prostate carcinomas and the matched normal prostate tissues adjacent to tumors compared to the normal prostates from donors without prostate cancer. 11987152 Human
stat3 tumor There was no significant difference of Stat3 activity in foci of tumor and normal prostate tissue adjacent to tumor. 11987152 Human
stat3 prostate carcinomas No correlation was seen between Stat3 activity and Gleason grade or serum PSA levels in samples from prostate carcinomas. 11987152 Human
stat3 prostate cancer CONCLUSIONS: These results indicate that Stat3 is constitutively activated in prostate cancer. 11987152 Human
stat3 tumors The high level of Stat3 activity in both the prostate carcinomas and the normal prostate tissues adjacent to tumors suggests that Stat3 activation may occur before detectable histological alterations of the prostate. 11987152 Human
stat3 prostate carcinomas The high level of Stat3 activity in both the prostate carcinomas and the normal prostate tissues adjacent to tumors suggests that Stat3 activation may occur before detectable histological alterations of the prostate. 11987152 Human
stat3 myeloma In contrast, the myeloma line ANBL6 proliferates when stimulated with IL-6 and this correlates with prolonged STAT3 activation and up-regulation of bcl-X(L) and c-myc. 12040451 Human
stat3 multiple myeloma (mm) To study IL-6 signal transduction in multiple myeloma (MM), we employed chimeric receptors composed of the epidermal growth factor receptor (EGFR) extracellular domain, gp130 transmembrane domain, and full-length or truncated gp130 cytoplasmic domains lac 12040452 Human
stat3 human ovarian carcinomas Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. 12061840 Human
stat3 ovarian carcinomas STAT3, of one the signaling proteins downstream of the oncostatin M/LIF receptors, was found in its phosphorylated, activated form (phosphotyrosine 705 STAT3) in the malignant epithelial cells of 17 of 23 ovarian carcinomas examined (74%) as determined by 12061840 Human
stat3 ovarian carcinoma Recombinant human Oncostatin M (rhOSM) can induce the transient tyrosine 705 phosphorylation of STAT3 in serum-starved LIFR beta/OSMR beta expressing ovarian carcinoma cell lines, but does not alter cell growth and effects only a modest increase in the ap 12061840 Human
stat3 ovarian carcinomas Oncostatin M and its receptors may be part of a network of cytokine systems within ovarian carcinomas that may act to maintain STAT3 in its activated form, a phenomenon associated with the malignant phenotype. 12061840 Human
stat3 primary tumor In 51 primary tumor samples from patients with squamous cell carcinoma of the p.o. tongue, there was a significant correlation between increased levels of the activated form of Stat3, phosphorylated-Stat3, and increased levels of cyclin D1 (P < 0.0001). 12067972 Human
stat3 squamous-cell carcinoma In 51 primary tumor samples from patients with squamous cell carcinoma of the p.o. tongue, there was a significant correlation between increased levels of the activated form of Stat3, phosphorylated-Stat3, and increased levels of cyclin D1 (P < 0.0001). 12067972 Human
stat3 papilloma These data indicate that PTEN negatively regulates STAT3 activation in HPV-infected papilloma cells. 12075083 Human
stat3 human prostate cancer p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3. 12082540 Human
stat3 human prostate cancer Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. 12082540 Human
stat3 prostate cancer Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3 12082540 Human
stat3 cancer Further, we evaluated a series of established human prostate, breast, and ovarian cancer cell lines and found that all cancer cell lines expressing constitutively active Stat3, only harbor mutated or deleted p53. 12082540 Human
stat3 ovarian cancer Further, we evaluated a series of established human prostate, breast, and ovarian cancer cell lines and found that all cancer cell lines expressing constitutively active Stat3, only harbor mutated or deleted p53. 12082540 Human
stat3 cancer One implication of these results is that the anti-proliferative activities of p53 may not be compatible with the constitutive Stat3 signal in cancer cells. 12082540 Human
stat3 human breast cancers Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation. 12082622 Human
stat3 mammary adenocarcinomas Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation. 12082622 Human
stat3 leukemia Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation. 12084939 Human
stat3 hepatoma We designated this receptor 'mouse IL-22 binding protein' (mIL-22BP). mIL-22BP could be upregulated by LPS stimulation in mouse monocytes. mIL-22BP binds to mouse and human IL-22 and neutralizes STAT3 activation induced by both cytokines in huma 12700595 Human
stat3 lncap human prostate cancer Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice. 12111703 Human
stat3 cancers Stat3, a member of the family of signal transducers and activators of transcription, is activated in numerous cancers, including prostate. 12111703 Human
stat3 prostate cancer This study is to investigate the role of Stat3 activation in the growth of prostate cancer cells. 12111703 Human
stat3 prostate cancer METHODS: A constitutively active Stat3 was ectopically expressed in androgen-sensitive LNCaP prostate cancer cells and resulting stable clones expressing activated Stat3 were isolated. 12111703 Human
stat3 androgen-independent prostate cancer RESULTS: We show that the levels of activated Stat3 are associated with the progression of androgen-independent prostate cancer. 12111703 Human
stat3 prostate cancer Activation of Stat3 in androgen-sensitive LNCaP prostate cancer cells results in enhancement of tumor growth in both intact and castrated male nude mice and enhances androgen receptor-mediated prostate specific antigen expression. 12111703 Mouse
stat3 tumor Activation of Stat3 in androgen-sensitive LNCaP prostate cancer cells results in enhancement of tumor growth in both intact and castrated male nude mice and enhances androgen receptor-mediated prostate specific antigen expression. 12111703 Mouse
stat3 prostate cancer CONCLUSIONS: These findings demonstrate that intracellular signaling mediated by Stat3 can enhance the growth of androgen-sensitive human LNCaP prostate cancer cells in both intact and castrated male nude mice. 12111703 Mouse
stat3 colon carcinoma Gamma interferon down-regulates Fer and induces its association with inactive Stat3 in colon carcinoma cells. 12118379 Human
stat3 colon carcinoma Thus, Fer and Stat3 are two proliferation-promoting factors whose down-regulation could contribute to the cytostatic activity of IFN-gamma in colon carcinoma cells. 12118379 Human
stat3 malignant tumors In various types of human malignant tumors STAT3 has been shown to be constitutively activated due to aberrant production of cytokines and growth factors. 12131365 Human
stat3 renal-cell carcinoma We examined the presence of STAT3 activation and its association with pathological features and clinical outcome in renal cell carcinoma cases. 12131365 Human
stat3 renal-cell carcinoma MATERIALS AND METHODS: We examined 48 paraffin embedded renal cell carcinoma specimens and corresponding nonneoplastic kidney tissues for the activation status of STAT3 on immunohistochemistry using anti-phospho-specific (p)-STAT3 antibody, which recogniz 12131365 Human
stat3 tumor Based on the percent of cells with positive nuclear staining the activation status of STAT3 was determined and categorized into 2 groups, including low-less than 10% and high-90% or more tumor cells positive. 12131365 Human
stat3 metastatic disease A high level of p-STAT3 was a significant indicator of a poor prognosis on univariate and multivariate analysis (p = 0.0117 and 0.0439, respectively) CONCLUSIONS: Our results indicate a high frequency of STAT3 activation in renal cell carcinoma, especiall 12131365 Human
stat3 renal-cell carcinoma A high level of p-STAT3 was a significant indicator of a poor prognosis on univariate and multivariate analysis (p = 0.0117 and 0.0439, respectively) CONCLUSIONS: Our results indicate a high frequency of STAT3 activation in renal cell carcinoma, especiall 12131365 Human
stat3 renal-cell carcinoma STAT3 activation was an independent prognostic variable in renal cell carcinoma cases. 12131365 Human
stat3 renal-cell carcinoma Our results strongly suggest that the activation of STAT3 contributes to the development and progression of renal cell carcinoma. 12131365 Human
stat3 esophageal squamous-cell carcinoma STAT1 and STAT3 might be regulated differently in esophageal squamous cell carcinoma. 12162419 Human
stat3 head and neck squamous cell carcinoma STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. 12193474 Human
stat3 tumor STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. 12193474 Human
stat3 tumor Here, we evaluated the role of activated STAT3 in tumor progression and EGFR-independent mitogenic signaling. 12193474 Human
stat3 tumor We found that SCCHN cells stably transfected with a dominant active STAT3 construct expressed elevated levels of STAT3 target genes, including Bcl-X(L) and cyclin D1, and demonstrated increased proliferation in vitro and more rapid tumor growth rates in v 12193474 Human
stat3 tumor These findings provide evidence that constitutive STAT3 activation contributes to tumor growth in SCCHN, independent of the EGFR autocrine axis. 12193474 Human
stat3 leukemia RESULTS: We show that interleukin 6, leukemia inhibitory factor and interferon gamma treatment induce the nuclear STAT3 and STAT1 proteins to bind to the sis inducible element of c-fos in both C6 glioma cells and primary cortical astrocytes. 12195235 Human
stat3 c6 glioma RESULTS: We show that interleukin 6, leukemia inhibitory factor and interferon gamma treatment induce the nuclear STAT3 and STAT1 proteins to bind to the sis inducible element of c-fos in both C6 glioma cells and primary cortical astrocytes. 12195235 Rat
stat3 cancers Among them, STAT3 is often constitutively phosphorylated and activated in human cancers and in transformed cell lines and is implicated in tumorigenesis. 12208879 Human
stat3 human tumor However, cause of the persistent activation of STAT3 in human tumor cells is largely unknown. 12208879 Human
stat3 leukaemia Here we describe how the cytokine leukaemia inhibitory factor (LIF) sustains self-renewal through activation of the transcription factor STAT3, and how two other signals - extracellular-signal-related kinase (ERK) and phosphatidylinositol-3-OH kinase (PI3 12220864 Human
stat3 cancer Understanding the IFN-dependent regulation of STAT3 is of increasing interest because recent studies have demonstrated that STAT3 may play a role in cancer. 12105218 Human
stat3 cancer Studies have revealed that STAT3 is constitutively active in a number of cancer cell lines and that overexpression of an active form of STAT3 transforms normal fibroblasts. 12105218 Human
stat3 fibrosarcoma The regulation of STAT3 activation by IFNs was measured in a human lung fibrosarcoma cell line lacking IFNAR2c but stably expressing various IFNAR2c tyrosine mutants. 12105218 Human
stat3 leukemia To better understand how leukemia inhibitory factor (LIF) activates proopiomelanocortin (POMC) gene transcription in pituitary corticotrophs, time-course studies of the induction of POMC promoter activity and specific tyrosine phosphorylation of signal tr 12239103 Human
stat3 hepatic tumor Furthermore, STAT3-C, a constitutively active form of STAT3, suppressed transcription of the cyclin D1 promoter in fetal hepatocytes, whereas it activated the transcription in hepatic tumor cells, huH7 and HepG2. 12147685 Human
stat3 human tumors Constitutive activation of Stat3 alpha by upstream oncoproteins and receptor tyrosine kinases has been found in many human tumors and tumor-derived cell lines. 11940572 Human
stat3 melanoma tumor Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. 12370822 Human
stat3 cancers Activation of protein tyrosine kinases is prevalent in human cancers and previous studies have demonstrated that Stat3 signaling is a point of convergence for many of these tyrosine kinases. 12370822 Human
stat3 cancers Moreover, a critical role for constitutive activation of Stat3 in tumor cell proliferation and survival has been established in diverse cancers. 12370822 Human
stat3 tumor Moreover, a critical role for constitutive activation of Stat3 in tumor cell proliferation and survival has been established in diverse cancers. 12370822 Human
stat3 melanoma In this study, we demonstrate that Stat3 is constitutively activated in a majority of human melanoma cell lines and tumor specimens examined. 12370822 Human
stat3 tumor In this study, we demonstrate that Stat3 is constitutively activated in a majority of human melanoma cell lines and tumor specimens examined. 12370822 Human
stat3 melanoma Blocking Src tyrosine kinase activity, but not EGF receptor or JAK family kinases, leads to inhibition of Stat3 signaling in melanoma cell lines. 12370822 Human
stat3 melanoma Significantly, melanoma cells undergo apoptosis when either Src kinase activity or Stat3 signaling is inhibited. 12370822 Human
stat3 melanoma tumor These findings demonstrate that Src-activated Stat3 signaling is important for the growth and survival of melanoma tumor cells. 12370822 Human
stat3 breast cancer Experimental Design: In this study we have separately determined activation of STAT1, STAT3, and STAT5 by measuring their DNA binding activity and tyrosine phosphorylation in breast cancer tissue samples. 12374673 Human
stat3 tumors Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. 12438264 Human
stat3 prostate cancer Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. 12438264 Human
stat3 human prostate cancer Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors. 12438264 Human
stat3 tumors Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors. 12438264 Human
stat3 adenocarcinomas An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues. 12438264 Human
stat3 tumors An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues. 12438264 Human
stat3 tumor A highly specific immunohistochemical assay for detection of phospho-Stat3 revealed that elevated Stat3 activity was localized primarily in the tumor cells of prostate carcinoma specimens. 12438264 Human
stat3 prostate carcinoma A highly specific immunohistochemical assay for detection of phospho-Stat3 revealed that elevated Stat3 activity was localized primarily in the tumor cells of prostate carcinoma specimens. 12438264 Human
stat3 malignant tumors Furthermore, higher levels of Stat3 activation in patient specimens were correlated significantly with more malignant tumors exhibiting higher Gleason scores. 12438264 Human
stat3 human prostate cancer In addition, all of the three human prostate cancer cell lines examined (DU145, PC3, and LNCaP) displayed constitutive activation of Stat3. 12438264 Human
stat3 prostate cancer Our findings demonstrate that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells. 12438264 Human
stat3 prostate adenocarcinomas Our findings demonstrate that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells. 12438264 Human
stat3 prostate cancer These studies further suggest that Stat3 signaling represents a potentially novel molecular target for prostate cancer therapy. 12438264 Human
stat3 schwannoma We now show that both schwannomin and HRS inhibit Stat3 activation and that schwannomin suppresses Stat3 activation mediated by IGF-I treatment in the human schwannoma cell line STS26T. 12444102 Human
stat3 schwannoma We also find that schwannomin inhibits Stat3 and Stat5 phosphorylation in the rat schwannoma cell line RT4. 12444102 Human
stat3 leukemia M1 mouse myeloid leukemia cells arrest growth and differentiate into macrophages following treatment with interleukin 6 (IL-6) or leukemia inhibitory factor (LIF), and recent studies have shown that Stat3 plays a central role in this process. 12444555 Mouse
stat3 myeloid leukemia M1 mouse myeloid leukemia cells arrest growth and differentiate into macrophages following treatment with interleukin 6 (IL-6) or leukemia inhibitory factor (LIF), and recent studies have shown that Stat3 plays a central role in this process. 12444555 Mouse
stat3 basal-cell carcinoma Transfection with dominant-negative STAT3 (STAT3F) into inter-leukin-6-treated basal cell carcinoma cells caused a decrease of phosphotyrosyl STAT3 but did not alter Mcl-1 protein levels; however, AG490, a Janus tyrosine kinase inhibitor, was capable of i 12445202 Human
stat3 basal-cell carcinoma Taken together, our data suggest that both the phosphotidyl inositol 3-kinase/Akt and STAT3 pathways are potentially involved in interleukin-6-mediated cell survival activity in basal cell carcinoma cells; however, the upregulation of the anti-apoptotic M 12445202 Human
stat3 oral squamous-cell carcinoma Treatment of oral squamous cell carcinoma cells with 15-PGJ(2) induced an initial reduction and eventual elimination of both phosphorylated and unphosphorylated Stat3 protein levels. 12454768 Human
stat3 oral squamous-cell carcinoma Our results provide the first evidence of significant antineoplastic effects of 15-PGJ(2) on human oral squamous cell carcinoma cells, which may be related to downmodulation of Stat3 and are at least partly mediated through PPARgamma-independent events. 12454768 Human
stat3 tumor The transcription factors Stat3 and NF-kappaB induce increased Bcl-x(L) expression in the premalignant lesions and tumor cells. 12454861 Human
stat3 pancreatic tumor Functional analysis shows that blocking of both Stat3 and NF-kappaB together induces programmed cell death in murine pancreatic tumor cells. 12454861 Mouse
stat3 tumor Therefore, combined inhibition of Stat3 and NF-kappaB might represent a novel strategy for tumor prevention and therapy. 12454861 Mouse
stat3 glioblastoma multiforme Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. 12466961 Human
stat3 cancer Stat3, a latent transcription factor being activated by aberrant cytokine or growth factor signaling, acts as a suppressor of apoptosis in a number of cancer cells. 12466961 Human
stat3 tumors Here we report that GBM tumors and cell lines contain high levels of constitutively activated Stat3 when compared with normal human astrocytes, white matter, and normal tissue adjacent to tumor. 12466961 Human
stat3 tumor Here we report that GBM tumors and cell lines contain high levels of constitutively activated Stat3 when compared with normal human astrocytes, white matter, and normal tissue adjacent to tumor. 12466961 Human
stat3 glioblastoma These results provide evidence that constitutive activation of Stat3 contributes to the pathogenesis of glioblastoma by promoting both proliferation and survival of GBM cells. 12466961 Human
stat3 hepatoma It is known that during acute phase reaction IL-6 activates STAT3 in hepatoma cells and IL-1 downregulates this response. 12502184 Human
stat3 cutaneous t-cell lymphoma SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. 12543077 Human
stat3 melanoma Treatment of melanoma cells with dexamethasone (DEX) resulted in coexpression of STAT3 activation and increase in the PI-3 kinase protein level. 12589944 Human
stat3 melanoma Prolonged DEX treatment of melanoma cells resulted in constitutive increases in both STAT3 and PI-3 kinase protein levels that were correlated with increased melanoma resistance to antiproliferative hormone action. 12589944 Human
stat3 melanoma Similarly, forced expression of both STAT3 and PI-3 kinase in melanoma cells led to enhanced resistance to hormone treatment. 12589944 Human
stat3 prostate carcinoma Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. 11141475 Human
stat3 prostate carcinoma In the DU-145 prostate carcinoma cell line, rhIL-11 stimulates a transient and dose-dependent increase in the tyrosine 705-phosphorylated, active form of STAT3 (STAT3 P-Tyr705), involved in the downstream signaling of IL-11R and other members of the gp130 11141475 Human
stat3 prostate carcinoma Thus, the IL-11 receptor system is up-regulated in prostate carcinoma, and may be one part of a cytokine network that maintains STAT3 in its activated form in these tissues. 11141475 Human
stat3 breast carcinoma The constitutive activation of signal transducer and activator of transcription 3 (Stat3) is frequently detected in breast carcinoma cell lines but not in normal breast epithelial cells. 14715258 Human
stat3 tumor Stat3 has been classified as an oncogene because activated Stat3 can mediate oncogenic transformation in cultured cells and tumor formation in nude mice. 14715258 Mouse
stat3 human breast carcinoma As the result of Stat3 knock-down by Stat3 short interfering RNA oligonucleotides in MDA-MB-468 human breast carcinoma cells, HSP27 was markedly reduced consistent with Stat3 reduction. 14715258 Human
stat3 breast carcinoma Furthermore, we observed that Stat3 was physically associated with HSP27 and HSP90 in MDA-MB-468 breast carcinoma cells. 14715258 Human
stat3 tumor Expression of SOCS-3 coincides with a constitutive activation of STAT3 in CTCL tumor cells, and stable transfection of CTCL tumor cells with a dominant negative STAT3 strongly inhibits SOCS-3 expression, whereas transfection with wild-type STAT3 does not. 11159537 Human
stat3 human prostate cancer Here, we showed that, in Du-145 human prostate cancer cells, enhanced expression of BRCA1 resulted in constitutive activation of signal transducer and activator transcription factor 3 (STAT3) tyrosine and serine phosphorylation. 11163768 Human
stat3 leukemia These findings suggest that investigation should focus on novel strategies targeting STAT3 in the treatment of LGL leukemia. 11160159 Human
stat3 nasopharyngeal carcinoma Immunohistochemical analyses of nasopharyngeal carcinoma tumors revealed that STAT3, STAT5, and STAT1 are constitutively activated in these tumors while STAT3 is constitutively activated in the malignant cells of Hodgkin's disease. 11222718 Human
stat3 tumors Immunohistochemical analyses of nasopharyngeal carcinoma tumors revealed that STAT3, STAT5, and STAT1 are constitutively activated in these tumors while STAT3 is constitutively activated in the malignant cells of Hodgkin's disease. 11222718 Human
stat3 human hepatoma To elucidate the cross-talk between IL-6 and TGF-beta signaling pathways in hepatic cells, we investigated the effects of TGF-beta on IL-6-induced signal transducer and activator of transcription-3 (STAT3) activation in a human hepatoma cell line, Hep3B. 11257503 Human
stat3 mammary carcinoma Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells. 11278729 Human
stat3 breast carcinoma Collectively, our data indicate a cooperative effect of c-Src kinase and Stat3 in the activation of HGF transcription and protein expression in breast carcinoma cells. 11278729 Human
stat3 tumors Gene therapy of B16 tumors with a dominant-negative signal transducer and activator of transcription (Stat3) variant, designated Stat3beta, results in inhibition of tumor growth and tumor regression. 11309279 Human
stat3 tumor Gene therapy of B16 tumors with a dominant-negative signal transducer and activator of transcription (Stat3) variant, designated Stat3beta, results in inhibition of tumor growth and tumor regression. 11309279 Human
stat3 condylomas Accordingly, we determined mRNA levels of IFN-gamma and IFN-gamma receptors, levels of IFN-gamma receptor-associated kinases (JAK1 and TYK2) and signalling molecules (signal transducer and activator of transcription-1 [STAT1], STAT3, interferon-responsive 11319973 Human
stat3 prostate cancer We provide evidence that these activities are due to direct physical interactions between STAT3 and AR in prostate cancer cells. 11322786 Human
stat3 human lung cancer STAT3 and MAPK in human lung cancer tissues and suppression of oncogenic growth by JAB and dominant negative STAT3. 15010832 Human
stat3 human lung carcinoma To search for the signaling events in lung carcinoma relevant to its tumorigenesis, we investigated the phosphorylation of MAPK and STAT3 in human lung carcinoma tissues and their paired normal tissues. 15010832 Human
stat3 lung carcinoma To search for the signaling events in lung carcinoma relevant to its tumorigenesis, we investigated the phosphorylation of MAPK and STAT3 in human lung carcinoma tissues and their paired normal tissues. 15010832 Human
stat3 lung carcinoma Moreover, exogenous expression of either JAB or dominant negative STAT3 in lung carcinoma cell lines led to the suppression of STAT3 phosphorylation and the drastic reduction of anchorage- independent growth of the cells. 15010832 Human
stat3 cancer Meanwhile, cisplatin also inhibited Stat3 tyrosine phosphorylation and down-regulated BcL-XL anti-apoptotic protein in the cancer cells tested. 15010843 Human
stat3 hepatoma Insulin attenuates leptin-induced STAT3 tyrosine-phosphorylation in a hepatoma cell line. 12890573 Human
stat3 m1 leukemia STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. 11337018 Human
stat3 acute myeloid leukemia Interleukin-6 (IL-6), a pleiotropic cytokine, induces a robust and sustained activation of STAT3 in M1 acute myeloid leukemia cells, which in turn undergo growth arrest, terminal differentiation and apoptosis in response to IL-6. 11337018 Human
stat3 m1 leukemia This observation is in accordance with previous reports and confirms that STAT3 plays an essential role in IL-6-induced growth arrest and terminal differentiation in M1 leukemia cells. 11337018 Human
stat3 m1 leukemia As proliferation inhibition and differentiation induction stands for a negative signal, while survival maintenance stands for a positive signal, we conclude that STAT3 exerts two-way regulation on the biological effects of IL-6 in M1 leukemia cells. 11337018 Human
stat3 acute myeloid leukemia (aml) We have previously demonstrated that while constitutively active STAT proteins were detected in ten of 36 (28%) for STAT3 and eight of 36 (22%) for STAT5 in pretreatment samples from newly diagnosed acute myeloid leukemia (AML) patients, a significantly l 11337019 Human
stat3 tumor We show that (1) STAT3 (a transcription factor known to regulate IL-2Ralpha transcription) is constitutively tyrosine-phosphorylated in SS tumor cells, but not in non-malignant T cells; (2) STAT3 binds constitutively to a STAT-binding sequence in the prom 11368440 Human
stat3 tumor In conclusion, we provide the first example of a constitutive STAT3 activation in SS tumor cells. 11368440 Human
stat3 leukemia Suppression of STAT3 activation by a dominant negative molecule in MO7e leukemia cells transduced with mutant c-kit inhibits stem cell factor (SCF)-independent survival and proliferation, accompanied by the down-regulation of Bcl-x(L) and c-myc. 11369651 Human
stat3 polycythemia rubra vera STAT3 is constitutively active in some patients with Polycythemia rubra vera. 11378264 Human
stat3 multiple myeloma Using TGFbeta-producing multiple myeloma tumor cells we demonstrate that tumor-derived TGFbeta can block IL-2-induced proliferation and STAT3 and STAT5 phosphorylation in T cells. 11418694 Human
stat3 tumor Using TGFbeta-producing multiple myeloma tumor cells we demonstrate that tumor-derived TGFbeta can block IL-2-induced proliferation and STAT3 and STAT5 phosphorylation in T cells. 11418694 Human
stat3 tumor High affinity IL-2R expression was required for the suppression of IL-2 responses as a novel CD25(-) T cell line proliferated and phosphorylated STAT3 when cultured with tumor cells or rTGFbeta1. 11418694 Human
stat3 tumor Activating T cells with IL-15, which does not use the high affinity IL-2R, completely restored the ability of T cells to phosphorylate STAT3 and STAT5 when cultured with tumor cells. 11418694 Human
stat3 tumor Preincubation with IL-15 also restored the ability of T cells to respond to IL-2 by phosphorylating STAT3 and STAT5, and proliferating normally in the presence of tumor cells. 11418694 Human
stat3 human breast carcinoma Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. 11420660 Human
stat3 human breast cancer We have previously demonstrated a high frequency of Stat3 DNA-binding activity that is constitutively-induced by an unknown mechanism in human breast cancer cell lines possessing elevated EGF receptor (EGF-R) and c-Src kinase activities. 11420660 Human
stat3 human breast cancer Using tyrosine kinase selective inhibitors, we show here that Src and JAK family tyrosine kinases cooperate to mediate constitutive Stat3 activation in the absence of EGF stimulation in model human breast cancer cell lines. 11420660 Human
stat3 breast cancer In addition, transfection of a dominant-negative form of Stat3 leads to growth inhibition involving apoptosis of breast cancer cells. 11420660 Human
stat3 breast cancer While EGF-R kinase activity is not required for constitutive Stat3 activation in breast cancer cells, EGF stimulation further increases STAT DNA-binding activity, consistent with an important role for EGF-R in STAT signaling and malignant progression. 11420660 Human
stat3 human breast cancer Our findings, taken together, suggest that tyrosine kinases transduce signals through Stat3 protein that contribute to the growth and survival of human breast cancer cells in culture and potentially in vivo. 11420660 Human
stat3 cervical carcinoma CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells: imbalance between NF-kappaB and STAT3 activation. 11426939 Human
stat3 lymphoma Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cyto 11431352 Human
stat3 melanoma Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity. 11442760 Human
stat-3 tumor Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. 14702634 Human
stat-3 tumor We report here that constitutive activation of Stat-3, a common oncogenic signaling pathway, suppresses tumor expression of proinflammatory mediators. 14702634 Human
stat-3 tumor Blocking Stat-3 in tumor cells increases expression of proinflammatory cytokines and chemokines that activate innate immunity and dendritic cells, leading to tumor-specific T-cell responses. 14702634 Human
stat-3 tumor Thus, inhibition of antitumor immunity involves a cascade of Stat-3 activation propagating from tumor to dendritic cells. 14702634 Human
stat-3 tumor We propose that tumor Stat-3 activity can mediate immune evasion by blocking both the production and sensing of inflammatory signals by multiple components of the immune system. 14702634 Human
stat3 burkitt lymphoma Gel retardation and Western blot analyses revealed a high level of constitutively activated STAT3 in 5 of 7 HD cell lines, which could not be detected in Burkitt lymphoma cell lines. 11468177 Human
stat3 tumor However, the tyrosine kinase inhibitor AG490 blocked the constitutive activation of STAT3 and inhibited spontaneous growth of HD tumor cells. 11468177 Human
stat3 human neuroblastoma Factors secreted by human neuroblastoma mediated doxorubicin resistance by activating STAT3 and inhibiting apoptosis. 11474132 Human
stat3 neuroblastoma This investigation analyzes the relationship between the development of resistance to doxorubicin-mediated apoptosis in neuroblastoma cells (SKN-SH) and activation of the Stat3 signaling pathway. 11474132 Human
stat3 tumor Transfection of dominant negative STAT3, but not STAT1 inhibits mutant c-Kit mediated anchorage-independent growth in vitro and tumor formation in vivo. 11494148 Human
stat3 melanoma The expression of dominant negative Stat3 or c-Jun in melanoma cells efficiently increased Fas expression and sensitized cells to FasL-induced apoptosis. 11463377 Human
stat3 tumor Our findings indicate that Stat3 oncogenic activities could also be mediated through its cooperation with c-Jun, resulting in downregulation of Fas surface expression, which is implicated in the tumor's ability to resist therapy and metastasize. 11463377 Human
stat3 multiple myeloma Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. 11429412 Human
stat3 other tumors These data directly demonstrate STAT3 to be a molecular participant in ER inhibition of the IL-6 signaling pathway in human MM cells and provides the molecular basis for the potential use of estrogenic ligands in the treatment of MM or other tumors where 11429412 Human
stat3 leukemia METHODS AND RESULTS: The effects of leukemia inhibitory factor (LIF) or adenovirus-mediated transfection of constitutively activated STAT3 (caSTAT3) on the intracellular ROS formation induced by hypoxia/reoxygenation (H/R) were examined using rat neonatal 11524388 Human
stat3 cutaneous t-cell lymphoma On testing cutaneous T cell lymphoma cell lines and skin lesions, we found that the transcription factors STAT2, STAT3, STAT5, and STAT6 (STAT, signal transducer and activator of transcription) were present in the nuclei of these cells and that the bindin 11564163 Human
stat3 cancer Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. 14688356 Human
stat3 tumor Tumor cell conditioned medium induced activation of Jak2 and STAT3, which was associated with an accumulation of immature myeloid cells. 14688356 Human
stat3 cancer Thus, this is a first demonstration that tumor-derived factors may affect myeloid cell differentiation in cancer via constitutive activation of Jak2/STAT3. 14688356 Human
stat3 multiple myeloma Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. 14975242 Human
stat3 leukemia It has recently been reported that a cytosolic isoform of PTPepsilon (PTPepsilonC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)- and leukemia inhibitory factor-induced activation of Janus kinases (JAKs), thereby suppressing 11698287 Human
stat3 breast cancer EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. 11713584 Human
stat3 cancer STAT3 activation has been demonstrated to have a role in oncogenesis and increasingly, activated STAT proteins are found to be activated in human cancer. 11713584 Human
stat3 breast cancers We report here a highly significant correlation between nuclear STAT3 expression and breast cancers compared to normal tissue. 11713584 Human
stat3 breast cancers We also report a very strong correlation between nuclear STAT3 and EGFR expression in breast cancers. 11713584 Human
stat3 leukemia The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cells. 11581263 Human
stat-3 prostate cancer Addition of exogenous IL-6 to primary epithelial cells in culture or the LNCaP prostate cancer cell line leads to phosphorylation of Stat-3 and increases in net cell proliferation. 11733366 Human
stat3 cancers STAT3 has also been demonstrated to mediate cellular transformation and is found in numerous cancers. 14975756 Human
stat3 breast cancer Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. 11753675 Human
stat3 tumor Constitutively active Stat3 has been shown to mediate oncogenic transformation in cultured cells and induce tumor formation in mice. 11753675 Mouse
stat3 cancer An increasing number of tumor-derived cell lines as well as samples from human cancer have been reported to express constitutively active Stat3 protein. 11753675 Human
stat3 ovarian cancer We previously demonstrated that ovarian cancer cell lines express high levels of constitutively active Stat3. 11753675 Human
stat3 breast cancer In this study, we show that inhibition of the Stat3 signaling pathway using the Janus Kinase-selective inhibitor, AG490, and a dominant negative Stat3 (Stat3beta) significantly suppresses the growth of ovarian and breast cancer cell lines harboring consti 11753675 Human
stat3 ovarian cancer In the ovarian cancer cell lines, AG490 also diminished the phosphorylation of Stat3, Stat3 DNA binding activity, and the expression of Bcl-x(L). 11753675 Human
stat3 breast cancer Further, AG490 induced significant apoptosis in ovarian and breast cancer cell lines expressing high levels of constitutively active Stat3 but had a less profound effect on normal cells lacking constitutively active Stat3. 11753675 Human
stat3 breast cancers These results suggest that inhibition of Stat3 signaling may provide a potential therapeutic approach for treating ovarian and breast cancers. 11753675 Human
stat3 myeloma OBJECTIVE: To investigate the regulation effect of protein kinase ERK on the activation of transcription factor STAT3 in response to IL-6 in the Sko-007 human myeloma cell line. 11780390 Human
stat3 tumor Surprisingly we did not see a clear correlation between tumor staging, grading or Stat3 signaling and EGF-R level but we observed up to three distinct EGF-R specific bands in our Western blots, implicating the presence of different protein isoforms. 11848502 Human
stat3 hyperplasia IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells. 11710966 Rat
stat3 cancer BACKGROUND: STAT3 phosphorylation is associated with the neoplastic state in many types of cancer, including prostate cancer. 11710966 Human
stat3 prostate cancer BACKGROUND: STAT3 phosphorylation is associated with the neoplastic state in many types of cancer, including prostate cancer. 11710966 Human
stat3 human prostate cancer STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP. 10617865 Human
stat3 prostate cancer METHODS: Prostate cancer cell lines were assayed for STAT3 activity by immunoblotting, electrophoretic gel shift assays (EMSA), and a luciferase reporter assay to test for STAT3 protein expression, phosphorylation, DNA binding, and transcriptional activit 10617865 Human
stat3 prostate cancer CONCLUSIONS: STAT3 transcriptional activation correlates with the growth-inhibitory signal of IL-6 in LNCaP, suggesting that STAT3 transcriptional activity is an important determinant in the different phenotypic responses to IL-6 in prostate cancer. 10617865 Human
stat3 prostate cancer STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells . 10639189 Human
stat3 prostate cancer Since differentiation and growth arrest are often associated processes, we investigated whether STAT3 also mediated NE differentiation in this prostate cancer cell line. 10639189 Human
stat3 prostate cancer CONCLUSIONS: These results indicate that STAT3 is a mediator of both NE differentiation and growth inhibition in LNCaP and PC-3, suggesting a connection between growth inhibition and NE differentiation in prostate cancer. 10639189 Human
stat3 prostate cancer Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway . 10639195 Human
stat3 neuroblastoma Here we investigate the kinase activity responsible for phosphorylation of STAT3 on Ser727 in CNTF-stimulated neuroblastoma cells. 10660304 Human
stat3 myeloma In this review, we argue a novel mechanism of proliferation of myeloma cells, in that the activation of both STAT3 and ERK1/2 is not sufficient for IL-6-induced proliferation which further requires IL-6-independent activation of the src family kinases ass 14565647 Human
stat3 prostate cancer CONCLUSIONS: IL-6 is a survival factor against cytotoxic agent-induced apoptosis through both STAT3 and bcl-xL pathways in prostate cancer cells. 15162378 Human
stat3 anaplastic large-cell lymphomas (alcls) Thus, we tested the hypothesis that TIMP1 expression is related to STAT3 activation in lymphomas, with a focus on anaplastic large cell lymphomas (ALCLs), which are known to express high levels of phosphorylated/active STAT3 (pSTAT3). 15161657 Human
stat3 lymphomas Thus, we tested the hypothesis that TIMP1 expression is related to STAT3 activation in lymphomas, with a focus on anaplastic large cell lymphomas (ALCLs), which are known to express high levels of phosphorylated/active STAT3 (pSTAT3). 15161657 Human
stat3 tumors We further evaluated the relationship between TIMP1 expression and STAT3 activation in 43 ALCL tumors (19 ALK(+) and 24 ALK(-)) using immunohistochemistry and a tissue microarray. 15161657 Human
stat3 tumors As expected, TIMP1 positivity was higher in the ALK(+) group (15 of 19, 79%) compared with the ALK(-) group (5 of 24, 21%; P = 0.0002) because NPM-ALK restricted to ALK(+) tumors was previously shown to activate STAT3. 15161657 Human
stat3 embryonal carcinoma The expression of alkaline phosphatase and embryonal carcinoma cell monoclonal antibody-1 and stage-specific embryonic antigen-1 and the activation of STAT3 were examined, all of which are indices of the undifferentiated state. 15044464 Human
stat3 human hepatoma Expression of Etk in a human hepatoma cell line Hep3B resulted in a significant increase in its transforming ability, and this effect was abrogated by dominant-negative inhibition of STAT3. 10688651 Human
stat3 brain tumour Activation of stat3 and stat1 DNA binding and transcriptional activity in human brain tumour cell lines by gp130 cytokines. 10704821 Human
stat3 prostate cancer Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. 10728680 Human
stat3 human prostate cancers We demonstrate that cells derived from both rat and human prostate cancers have constitutively activated Stat3, with Stat3 activation being correlated with malignant potential. 10728680 Human
stat3 human prostate cancer Blockade of activated Stat3 by ectopic expression of a dominant-negative Stat3 in human prostate cancer cells significantly suppresses their growth in vitro and their tumorigenicity in vivo. 10728680 Human
stat3 human prostate cancer Furthermore, the Janus kinase inhibitor, tyrphostin AG490, inhibited the constitutive activation of Stat3 and suppressed the growth of human prostate cancer cells. 10728680 Human
stat3 prostate cancer These results indicate that activation of Stat3 signaling is essential in the progression of prostate cancer cells and suggest that targeting Stat3 signaling may yield a potential therapeutic intervention for prostate cancer. 10728680 Human
stat3 cancer To determine the timing of Stat3 activation in head and neck carcinogenesis, we studied the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer compared with mucosa from controls without canc 10760290 Human
stat3 tumors To determine the timing of Stat3 activation in head and neck carcinogenesis, we studied the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer compared with mucosa from controls without canc 10760290 Human
stat3 head-and-neck cancer To determine the timing of Stat3 activation in head and neck carcinogenesis, we studied the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer compared with mucosa from controls without canc 10760290 Human
stat3 cancer Stat3 was up-regulated and constitutively activated in both primary human head and neck tumors as well as in normal mucosa from these cancer patients compared with control normal mucosa from patients without cancer. 10760290 Human
stat3 tumors Stat3 was up-regulated and constitutively activated in both primary human head and neck tumors as well as in normal mucosa from these cancer patients compared with control normal mucosa from patients without cancer. 10760290 Human
stat3 tumor In vivo liposome-mediated gene therapy with a Stat3 antisense plasmid efficiently inhibited Stat3 activation, increased tumor cell apoptosis, and decreased Bcl-x(L) expression in a head and neck xenograft model. 10760290 Human
stat3 prostate cancer IL-6 signals through Janus kinase, signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinase and is also able to induce androgen receptor (AR)-mediated gene activation in prostate cancer, which is an important proces 10786674 Human
stat3 prostate cancer We now show that IL-6-induced AR-mediated gene activation requires the activation of STAT3 by IL-6 in LNCaP prostate cancer cells. 10786674 Human
stat3 human tumor These findings not only identify STAT3 as an important signaling molecule required for IL-6-signaling to induce AR-mediated gene activation in prostate carcinoma cells but also reveal the importance of activated STAT3 in human tumor development and progre 10786674 Human
stat3 prostate carcinoma These findings not only identify STAT3 as an important signaling molecule required for IL-6-signaling to induce AR-mediated gene activation in prostate carcinoma cells but also reveal the importance of activated STAT3 in human tumor development and progre 10786674 Human
stat3 head-and-neck cancer Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer. 10807365 Human
stat3 tumor In these tumor cells in culture, EGFR stimulation initiates signaling via persistent activation of STAT proteins, particularly Stat3. 10807365 Human
stat3 tumor Downmodulation of Stat3 using a dominant-negative or antisense approach inhibited tumor cell growth and stimulated apoptosis. 10807365 Human
stat3 acute myeloid leukemia Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. 10845908 Human
stat3 acute myeloid leukemia (aml) To explore the activation patterns of signal transducer and activator of transcription 3 (Stat3) in acute myeloid leukemia (AML), we examined whether the phosphorylation of tyrosine705 (Tyr705) and serine727 (Ser727) residues was abnormally regulated in c 10845908 Human
stat3 tumors Targeting Stat3 leads to SCCHN growth inhibition, increases apoptosis and a downmodulation of Bcl-xL expression in head and neck tumors. 10851047 Human
stat3 leukemia Constitutive activation of STAT3 and/or STAT5 resulting in enhanced transcription of anti-apoptotic- cell-cycle progression genes is likely to contribute to the pathogenesis of various myeloid leukemia's. 10851050 Human
stat3 cervical cancer Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells. 10853013 Human
stat3 cervical cancer We examined whether the persistent activation of AKT or Stat3 oncogene product is present in prostate, breast, and cervical cancer cells. 10853013 Human
stat3 cancer Interestingly, the cancer cells, which only express low levels of phosphorylated AKT express high levels of phosphorylated Stat3. 10853013 Human
stat3 human papilloma AKT or Stat3 is also highly phosphorylated in human papilloma virus-negative cervical cancer cells. 10853013 Human
stat3 cervical cancer AKT or Stat3 is also highly phosphorylated in human papilloma virus-negative cervical cancer cells. 10853013 Human
stat3 cervical cancer Therefore, these results indicate that AKT and Stat3 are highly phosphorylated in some breast, prostate and cervical cancer cells, which may play a role in tumorigenesis of these cancers. 10853013 Human
stat3 cancers Therefore, these results indicate that AKT and Stat3 are highly phosphorylated in some breast, prostate and cervical cancer cells, which may play a role in tumorigenesis of these cancers. 10853013 Human
stat3 leukemia Following leukemia inhibitory factor stimulation, p21(WAF1/CIP1/SDI1) was found to associate with STAT3 proteins in coimmunoprecipitation and pull down assays. 10764767 Human
stat3 b-cell lymphoma STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression. 10896772 Human
stat3 b lymphoma Nuclear extracts from untreated primary B-1 or CD5(+) BCL(1) B lymphoma cells were found to contain immunoreactive STAT3 protein that binds to a sis-inducible element present in the promoter of the p21(waf1/cip1) tumor suppressor gene and is constitutivel 10896772 Human
stat3 b lymphoma To determine the functional significance of constitutive STAT3 activation in B lymphoma cells, a specific STAT3 antisense oligonucleotide was developed and used to examine basal BCL(1) cell growth and IgM production. 10896772 Human
stat3 b-cell lymphoma These results indicate that STAT3 controls cell growth and immunoglobulin secretion by enhancing progression through the G1 phase of the cell cycle in BCL(1) B cell lymphoma. 10896772 Human
stat3 carcinoma However, these carcinoma cell lines showed low responsiveness to IL-6 as revealed by low constitutive STAT3 binding activity, which was not further enhanced by exogenous IL-6. 10925276 Human
stat3 carcinoma Addition of soluble gp80 was sufficient to restore IL-6 responsiveness in carcinoma cells as shown by enhanced activation of STAT3 binding activity. 10925276 Human
stat3 glioblastoma Oncostatin M-mediated growth inhibition of human glioblastoma cells does not depend on stat3 or on mitogen-activated protein kinase activation. 10936178 Human
stat3 myeloma Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. 10979940 Human
stat 3 human ovarian carcinoma Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. 11006034 Human
stat 3 breast cancer Aberrations of Stat 3 in breast cancer have raised the possibility of its contribution to oncogenesis. 11006034 Human
stat 3 ovarian cancer Our goal was to examine ovarian cancer cell lines to determine whether Stat 3 plays a relevant role in ovarian carcinogenesis. 11006034 Human
stat 3 ovarian cancer CONCLUSIONS: Constitutive activation of Stat 3 is present in ovarian cancer lines but not in normal ovarian surface epithelial cells. 11006034 Human
stat 3 ovarian carcinoma The relationship of this aberrancy of ovarian carcinoma harboring activated Stat 3 deserves further investigation. 11006034 Human
stat3 cancers Among them, STAT3 is frequently activated in a number of human cancers and transformed cell lines and is implicated in tumorigenesis. 14737107 Human
stat3 t-47d human breast cancer Inhibition of oncogene STAT3 phosphorylation by a prolactin antagonist, hPRL-G129R, in T-47D human breast cancer cells. 11078803 Human
stat3 breast cancer In the present study, we test the hypothesis that the inhibitory effect of hPRL-G129R in breast cancer cells occurs, at least in part, through the inhibition of oncogene STAT3 activation. 11078803 Human
stat3 breast cancer We first demonstrated that STAT5 and STAT3 could be activated by either hGH or hPRL in T-47D breast cancer cells. 11078803 Human
stat3 carcinoma Here we report that treatment of human hepatocullular carcinoma HepG2 cells with IL-1beta inhibited the IL-6-dependent binding of signal transducer and activator of transcription factor (STAT)1, but not that of STAT3, to the high-affinity serum-inducible 11104703 Human
stat3 breast cancer IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) activity and STAT3-mediated gene expression were suppressed by 17beta-estradiol (E2) in breast cancer cells. 11113455 Human
stat3 leukemia Leukemia inhibitory factor enhances mast cell growth in a mast cell/fibroblast co-culture system through stat3 signaling pathway of fibroblasts. 11150513 Human
stat3 tumor We introduce an example in which the Stat3 arm of EGF receptor signaling is selectively inhibited by a peptide aptamer and causes the growth arrest of EGF receptor-dependent tumor cells. 13680379 Human
stat3 prostate cancers Frequently, however, abnormal activity of certain STAT family members, particularly Stat3 and Stat5, is associated with a wide variety of human malignancies, including hematologic, breast, head and neck, and prostate cancers. 11426647 Human
stat3 cancer Application of molecular biology and pharmacology tools in disease-relevant models has confirmed Stat3 as having a causal role in oncogenesis, and provided validation of Stat3 as a target for cancer drug discovery and therapeutic intervention. 11426647 Human
stat3 tumors Furthermore, a constitutively-active mutant form of Stat3 is sufficient to induce oncogenic transformation of cells, which form tumors in vivo. 11426647 Human
stat3 tumor Block of constitutive Stat3 signaling results in growth inhibition and apoptosis of Stat3-positive tumor cells in vitro and in vivo. 11426647 Human
stat3 cancer The observed dependence of certain tumors on constitutive Stat3 signaling for growth and survival has wide implications for cancer therapy, offering the potential for preferential tumor cell killing. 11426647 Human
stat3 tumors The observed dependence of certain tumors on constitutive Stat3 signaling for growth and survival has wide implications for cancer therapy, offering the potential for preferential tumor cell killing. 11426647 Human
stat3 tumor The observed dependence of certain tumors on constitutive Stat3 signaling for growth and survival has wide implications for cancer therapy, offering the potential for preferential tumor cell killing. 11426647 Human
stat3 neuroblastoma We show that IL-6 leads to transcriptional activation of signal transducer and activator of transcription 3 (STAT3) in human SH-SY5Y neuroblastoma cells. 10537060 Human
stat3 melanoma Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. 10537273 Mouse
stat3 tumor Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. 10537273 Mouse
stat3 cancers Whereas signal transducers and activators of transcription were originally discovered as mediators of normal cytokine signaling, constitutive activation of certain signal transducer and activator of transcription proteins, including Stat3, has been found 10537273 Human
stat3 cancer Recently, a causal role for Stat3 activation in oncogenesis has been demonstrated, suggesting that Stat3 represents a novel target for cancer therapy. 10537273 Human
stat3 b16 melanoma We report here that in vitro expression of a Stat3 variant with dominant-negative properties, Stat3beta, induced cell death in murine B16 melanoma cells that harbored activated Stat3. 10537273 Mouse
stat3 tumor By contrast, expression of Stat3beta had no effect on normal fibroblasts or the Stat3-negative murine tumor MethA, suggesting that only tumor cells with activated Stat3 have become dependent on this pathway for survival. 10537273 Human
stat3 cancers These findings demonstrate for the first time that interfering with Stat3 signaling induces potent antitumor activity in vivo and thus identify Stat3 as a potential molecular target for therapy of human cancers harboring activated Stat3. 10537273 Human
stat3 lymph-node metastases No relationship was found between nuclear localized Stat5a and menopausal status, tumor size, ploidy, percentage of cells in S-phase, lymph node metastases, ER, ErbB2, nuclear localized p21 or nuclear localized Stat5b/Stat3. 14696092 Human
stat3 tumor No relationship was found between nuclear localized Stat5a and menopausal status, tumor size, ploidy, percentage of cells in S-phase, lymph node metastases, ER, ErbB2, nuclear localized p21 or nuclear localized Stat5b/Stat3. 14696092 Human
stat3 papillomas As papillomas show abnormalities in terminal differentiation, we examined the potential role of STAT3 in regulating epithelial differentiation. 12865943 Human
stat3 human hepatoma In this study we show that LPS and TNFalpha are potent inhibitors of IL-6-mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. 10606755 Human
stat3 acute promyelocytic leukemia G-CSF induces apoptosis of a human acute promyelocytic leukemia cell line, UF-1: possible involvement of Stat3 activation and altered Bax expression. 10622210 Human
stat3 t-cell leukemia To further examine the cause of this signaling pathway deregulation, we measured mRNA and protein expression levels by real-time PCR and Western blots, respectively, of four negative regulators of the IL-2R signaling pathway including src homology 2 (SH2) 14630083 Human
stat3 multiple myeloma Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. 12969979 Human
stat3 myeloid leukemia Both Y704 and Y744 contributed to optimal activation of Stat3/beta in M1 murine myeloid leukemia cells containing wild-type and Y-to-F mutant G-CSFR constructs. 9864141 Human
stat3 myeloma Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. 10023775 Human
stat3 myeloma We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line U266. 10023775 Human
stat3 multiple myeloma We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line U266. 10023775 Human
stat3 myeloma Blocking IL-6 receptor signaling from Janus kinases to the Stat3 protein inhibits Bcl-xL expression and induces apoptosis, demonstrating that Stat3 signaling is essential for the survival of myeloma tumor cells. 10023775 Human
stat3 tumor Blocking IL-6 receptor signaling from Janus kinases to the Stat3 protein inhibits Bcl-xL expression and induces apoptosis, demonstrating that Stat3 signaling is essential for the survival of myeloma tumor cells. 10023775 Human
stat3 multiple myeloma These findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. 10023775 Human
stat3 melanoma Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. 10072444 Human
stat3 atypical nevi MATERIALS AND METHODS: To determine whether IFN-alpha, used for adjuvant therapy of high-risk, resected melanoma, induces changes in Stat3 in atypical nevi, patients with a clinical history of melanoma who have multiple atypical nevi were treated for 3 mo 10072444 Human
stat3 melanoma MATERIALS AND METHODS: To determine whether IFN-alpha, used for adjuvant therapy of high-risk, resected melanoma, induces changes in Stat3 in atypical nevi, patients with a clinical history of melanoma who have multiple atypical nevi were treated for 3 mo 10072444 Human
stat3 melanoma RESULTS: The results of the investigations provided evidence that, as a result of systemic IFN-alpha treatment, Stat1 and Stat3, which are constitutively activated in melanoma precursor lesions, lose their ability to bind DNA, and as shown in the case of 10072444 Human
stat3 atypical nevus The findings presented here suggest that down-regulation of the transcription factors Stat1 and Stat3 by systemic IFN-alpha treatment may represent a potential pathway to prevent the activation of gene(s) whose expression may be required for atypical nevu 10072444 Human
stat3 melanoma The findings presented here suggest that down-regulation of the transcription factors Stat1 and Stat3 by systemic IFN-alpha treatment may represent a potential pathway to prevent the activation of gene(s) whose expression may be required for atypical nevu 10072444 Human
stat3 leukemia Critical role for STAT3 in murine pituitary adrenocorticotropin hormone leukemia inhibitory factor signaling. 10196143 Human
stat3 neuroblastoma Ciliary neurotrophic factor and phorbol ester each decrease selected STAT3 pools in neuroblastoma cells by proteasome-dependent mechanisms. 10209066 Human
stat3 human neuroblastoma Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2. 10209066 Human
stat3 human erythroleukemia Similar observations were obtained with human erythroleukemia cells, where STAT3 phosphorylation was stimulated by C5a in a PTX-insensitive manner. 14551213 Human
stat3 adult t-cell lymphoma leukemia (atll) To determine activation status of the IL-2R-associated (Jak/STAT) pathway in the HTLV-I infected cells, we examined tyrosine phosphorylation of Jak3, STAT3, and STAT5 in several HTLV-I(+) T-cell lines and in uncultured leukemic T cells isolated from patie 10229324 Human
stat3 myeloma Although a reason for the overexpression in myeloma cells is not understood, very interestingly, the promoter region of the HM1.24 gene has a tandem repeat of three cis elements for a transcription factor, STAT3, which mediates interleukin-6 (IL-6) respon 10329429 Human
stat3 multiple myeloma Since IL-6 is a differentiation factor for B cells, and known as a paracrine/autocrine growth factor for multiple myeloma cells, the expression of HM1.24 antigen may be regulated by the activation of STAT3. 10329429 Human
stat3 lymphoma Short term incubation (<60 min) of prolactin-responsive Nb2 lymphoma cells at high density selectively blocked prolactin stimulation of p42/p44 mitogen-activated protein kinases and transcription factors Stat1 and Stat3 but not prolactin activation of Sta 10329665 Human
stat3 cancers Stat3 is an Src homology (SH)2-containing protein constitutively activated in a wide variety of human cancers following its recruitment to YXXQ-containing motifs, which results in resistance to apoptosis. 14966128 Human
stat-3 bladder cancer Overexpression of CDC91L1 also resulted in upregulation of the urokinase receptor (uPAR), a GPI-anchored protein, and in turn increased STAT-3 phosphorylation in bladder cancer cells. 15034568 Human
stat3 astrocytoma Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. 13678425 Human
stat3 cancers STAT3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas. 13678425 Human
stat3 astrocytoma METHODS: RNA interference was used to knockdown STAT3 expression in human astrocytes and astrocytoma cell lines. 13678425 Human
stat3 astrocytoma RESULTS: We have found that STAT3 is constitutively activated in several human astrocytoma cell lines. 13678425 Human
stat3 astrocytoma Knockdown of STAT3 expression by siRNA induces morphologic and biochemical changes consistent with apoptosis in several astrocytoma cell lines, but not in primary human astrocytes. 13678425 Human
stat3 glioblastoma Moreover, STAT3 is required for the expression of the antiapoptotic genes survivin and Bcl-xL in the A172 glioblastoma cell line. 13678425 Human
stat3 cancers In many cancers including liver, STAT3 is often constitutively activated, although the mechanism of persistent activation of STAT3 is unknown. 15063116 Human
stat3 hepatoma Introduction of NS5A in hepatoma cells modulated STAT3 downstream molecules Bcl-xL and p21 expression. 15063116 Human
stat3 hepatoma To determine if STAT3 activation by NS5A could induce STAT3 mediated gene expression, a luciferase reporter construct based on a synthetic promoter was used to transfect hepatoma cells. 15063116 Human
stat3 metastasis Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. 15116091 Human
stat3 tumor Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. 15116091 Human
stat3 metastatic tumor Moreover, a concomitant elevated Stat3 activity has been detected in these metastatic tumor cells that overexpress MMP-2. 15116091 Human
stat3 tumor Transfection of constitutively activated Stat3 into poorly metastatic C23 tumor cells directly activated the MMP-2 promoter, whereas the expression of a dominant-negative Stat3 in highly metastatic C4 tumor cells inhibited the MMP-2 promoter. 15116091 Human
stat3 metastatic tumor Blockade of activated Stat3 through expression of a dominant-negative Stat3 significantly suppressed MMP-2 expression in the metastatic tumor cells. 15116091 Human
stat3 metastatic melanoma Therefore, overexpression of MMP-2 in the metastatic melanoma cells can be attributed to elevated Stat3 activity, and Stat3 upregulates the transcription of MMP-2 through direct interaction with the MMP-2 promoter. 15116091 Human
stat3 metastasis Furthermore, blockade of activated Stat3 in highly metastatic C4 cells significantly suppressed the invasiveness of the tumor cells, inhibited tumor growth, and prevented metastasis in nude mice. 15116091 Mouse
stat3 tumor Furthermore, blockade of activated Stat3 in highly metastatic C4 cells significantly suppressed the invasiveness of the tumor cells, inhibited tumor growth, and prevented metastasis in nude mice. 15116091 Human
stat3 metastasis Collectively, these studies suggest that Stat3 signaling directly regulates MMP-2 expression, tumor invasion, and metastasis, and that Stat3 activation might be a crucial event in the development of metastasis. 15116091 Human
stat3 tumor Collectively, these studies suggest that Stat3 signaling directly regulates MMP-2 expression, tumor invasion, and metastasis, and that Stat3 activation might be a crucial event in the development of metastasis. 15116091 Human
stat3 anaplastic large-cell lymphoma Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma. 14506160 Human
stat3 non-hodgkins lymphomas PURPOSE: Recent data suggest that nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) activates signal transducers and activators of transcription 3 (STAT3) directly, and ALK expression correlates with STAT3 activation in non-Hodgkin's lymphomas. 14506160 Human
stat3 anaplastic large-cell lymphoma In this study, we evaluated comprehensively STAT3 activation status in anaplastic large cell lymphoma (ALCL) cell lines and pretreatment ALCL tumors. 14506160 Human
stat3 tumors In this study, we evaluated comprehensively STAT3 activation status in anaplastic large cell lymphoma (ALCL) cell lines and pretreatment ALCL tumors. 14506160 Human
stat3 tumors In ALCL tumors, STAT3 was considered active when > or =20% of neoplastic cells show unequivocal nuclear immunostaining for pSTAT3(tyr705). 14506160 Human
stat3 tumors In systemic ALCL, STAT3 activation was detected in 49 of 80 (61%) ALCL tumors: 26 of 31 (84%) ALK(+) tumors and 23 of 49 (47%) ALK(-) tumors. 14506160 Human
stat3 multiple myeloma Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. 15070700 Human
stat3 breast carcinoma Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells. 15007380 Human
stat3 breast carcinoma Since signalling through Stat3 is determined by a key phosphorylation at tyr705, we examined the effects of cell density upon Stat3 activity in normal breast epithelial cells, breast carcinoma lines and normal mouse fibroblasts. 15007380 Human
stat3 carcinoma On the other hand, constitutively active Stat3 in carcinoma lines, known to harbor activated Src, was blocked by pharmacological inhibitors of Src as well as JAKs. 15007380 Human
stat3 breast carcinomas These results point to the existence of two distinct pathways of Stat3 activation in breast carcinomas, based on Src dependence. 15007380 Human
stat3 lymphoma Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. 11751994 Human
stat3 anaplastic lymphoma Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. 11751994 Human
stat3 primary tumors Stat3 is constitutively activated in many primary tumors and tumor cell lines, suggesting that signaling by this molecule may be important for cell transformation. 11803465 Human
stat3 tumor Stat3 is constitutively activated in many primary tumors and tumor cell lines, suggesting that signaling by this molecule may be important for cell transformation. 11803465 Human
stat3 metastasis To address whether Stat3 is required for HGF/SF-Met mediated tumorigenesis and metastasis, we introduced a dominant-negative form of Stat3, Stat3beta into the human leiomyosarcoma cell line SK-LMS-1. 11803465 Human
stat3 leiomyosarcoma To address whether Stat3 is required for HGF/SF-Met mediated tumorigenesis and metastasis, we introduced a dominant-negative form of Stat3, Stat3beta into the human leiomyosarcoma cell line SK-LMS-1. 11803465 Human
stat3 mycosis fungoides Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. 10374878 Human
stat3 tumor Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. 10374878 Human
stat3 tumor Constitutive activation of Stat3 has recently been observed in many tumor cells and dysregulation of the Stat signaling pathway has been proposed to be implicated in malignant transformation. 10374878 Human
stat3 mycosis fungoides In a previous study, we found constitutively tyrosine phosphorylated Stat3 in mycosis fungoides tumor cells. 10374878 Human
stat3 tumor In a previous study, we found constitutively tyrosine phosphorylated Stat3 in mycosis fungoides tumor cells. 10374878 Human
stat3 prostate carcinoma CONCLUSIONS: From these data, we conclude that FGF-1 induces MT1-MMP expression in prostate carcinoma cells through a transcriptional mechanism mediated through the FGFR and the transcription factor, STAT3. 14673954 Human
stat3 lung cancer Restoration of SOCS-3 in lung cancer cells where SOCS-3 was methylation-silenced resulted in the down-regulation of active STAT3, induction of apoptosis, and growth suppression. 14617776 Human
stat3 cancers In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis. 10458605 Human
stat3 human tumors Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus attention on the importance of constitutive Stat3 activation in human tumors. 10458605 Human
stat3 human hepatoma By using Superose-6 gel-filtration chromatography, we have discovered that there is little monomeric STAT3 (91 kDa) in the cytosol of liver cells (human hepatoma Hep3B cell line and rat liver). 10464281 Human
stat3 meningiomas The authors also investigated, using tyrosine-phosphorylated Statl and Stat3 antibodies, whether STATs were activated in meningiomas and normal dura in vivo. 10470819 Human
stat3 meningiomas Their results indicate that both Statl and Stat3 are phosphorylated in vivo in meningiomas and in the dura. 10470819 Human
stat3 meningioma Furthermore, in vitro experiments in which two independent short-term cultures obtained from freshly dissected meningioma samples were used indicated that Statl and Stat3 are phosphorylated in response to treatment with IFNalpha-2B. 10470819 Human
stat3 meningioma Exposure of meningioma cells to IFNalpha-2B leads to nuclear translocation of tyrosine-phosphorylated Statl and Stat3, as demonstrated by immunocytochemical analysis. 10470819 Human
stat3 cutaneous t-cell lymphoma Here, we studied the role of serine/threonine phosphatases in STAT3 signaling in human antigen-specific CD4(+) T cell lines and cutaneous T cell lymphoma lines, expressing a constitutively activated STAT3. 10485875 Human
stat3 tumor STAT3 activity was recently found related to the malignant phenotype of different tumor cells and potentially contributes to their invasive properties. 14672334 Human
stat3 choriocarcinoma METHOD OF STUDY: We investigated the status of STAT3 activity in ex vivo trophoblast cells from first trimester and term placentae employing an electrophoretic mobility shift assay (EMSA) and compared it with that of a highly malignant choriocarcinoma cel 14672334 Human
stat3 choriocarcinoma The malignant phenotype of choriocarcinoma cells coincides with a high degree of STAT3 activity. 14672334 Human
stat3 ovarian tumor Using a panel of highly selective and structurally diverse Src inhibitors, we found that phosphorylation of signal transducer and activator of transcription 3 [STAT3 (Y705)] and focal adhesion kinase [FAK (Y861)] was SFK dependent in cultured human colon, 12748308 Human
stat3 tumor These data demonstrate that STAT3 (Y705) and FAK (Y861) phosphoepitopes are SFK-dependent in tumor cells and reveal a requirement for SFK function in tumor cell proliferation and vascular permeability. 12748308 Human
stat3 human hepatoma Stat3 fusion proteins with spectral variants of green fluorescent protein (GFP), cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP) were constructed and expressed in human hepatoma cells (HepG2) and human embryonic kidney cells (HEK-293). 12974672 Human
stat3 human tumors Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. 9566875 Human
stat3 leukemia Treatment of M1 myeloid leukemia cells with leukemia inhibitory factor (LIF) causes activation of transcription factors Stat1, Stat3 and Stat5a (signal transducers and activators of transcription). 9606990 Human
stat3 m1 myeloid leukemia Treatment of M1 myeloid leukemia cells with leukemia inhibitory factor (LIF) causes activation of transcription factors Stat1, Stat3 and Stat5a (signal transducers and activators of transcription). 9606990 Human
stat3 human leukemia A novel function of Stat1 and Stat3 proteins in erythropoietin-induced erythroid differentiation of a human leukemia cell line. 9657745 Human
stat3 acute myeloid leukemia (aml) Recently, constitutively activated Stat1, Stat3, and Stat5 were identified in nuclear extracts of acute myeloid leukemia (AML) patients, suggesting involvement of constitutive Stat activity in the events of leukemogenesis. 9694725 Human
stat3 tumors RESULTS: Our analyses revealed that Jak1 and Stat3 were consistently more elevated in low grade gliomas (LG) (tumors characterized by a more pronounced glial phenotype) as compared to high grade gliomas (HG) (less differentiated glial tumors). 9703883 Human
stat3 glial tumors RESULTS: Our analyses revealed that Jak1 and Stat3 were consistently more elevated in low grade gliomas (LG) (tumors characterized by a more pronounced glial phenotype) as compared to high grade gliomas (HG) (less differentiated glial tumors). 9703883 Human
stat3 other tumors Among the other tumors analyzed, medulloblastoma contained the highest level of Jak1 and Stat3, while ependymoma showed elevated levels of ShcA proteins. 9703883 Human
stat3 ependymoma Among the other tumors analyzed, medulloblastoma contained the highest level of Jak1 and Stat3, while ependymoma showed elevated levels of ShcA proteins. 9703883 Human
stat3 human erythroleukemia Using TF-1, a GM-CSF-dependent human erythroleukemia cell line, we found that GM-CSF enhanced DNA-binding and tyrosine phosphorylation of STAT3. 9714332 Human
stat3 myeloid leukemia Although treatment with IL-6 increased the amount of activated transcription factor Stat3 in the myeloid leukemia line C, differentiation was not induced. 9753648 Human
stat3 multiple myeloma Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. 14500688 Human
stat3 multiple myeloma (mm) Numerous reports suggest that IL-6 promotes survival and proliferation of multiple myeloma (MM) cells through the phosphorylation of a cell signaling protein, STAT3. 14500688 Human
stat3 myeloma In contrast, a cell-permeable STAT3 inhibitor peptide that can inhibit the STAT3 phosphorylation mediated by Src blocked the constitutive phosphorylation of STAT3 and also suppressed the growth of myeloma cells. 14500688 Human
stat3 m1 leukemia CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. 9811457 Human
stat3 breast cancer We now show that progestin treatment of breast cancer cells regulates Stat5a and 5b, Stat3, and Stat1 protein levels in a PR-dependent manner. 9813040 Human
stat3 carcinoma We show that members of the STAT family of transcription factors, including STAT1 and STAT3, are activated in fibroblasts and A-431 carcinoma cells in response to H2O2. 9843726 Human
stat3 pancreatic cancer In this study, we elucidated the significance of Janus kinase (JAK) and the downstream transcription factor Stat3 signals on malignant potentials of pancreatic cancer. 14580692 Human
stat3 human pancreatic cancer Electrophoretic mobility shift assay and immunohistochemical analysis revealed that Stat3 was constitutively activated in subsets of human pancreatic cancer tissues and cell lines (Panc1, Kp4, AsPC-1, BxPC-3). 14580692 Human
stat3 pancreatic cancer A JAK-specific inhibitor, tyrphostin AG490, markedly inhibited Stat3 activation and expression of cyclin D1, bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR, as followed by growth arrest (6.3-21.3% vs controls; P<0.001) of pancreat 14580692 Human
stat3 pancreatic cancer Inactivation of Stat3 by dominant-negative Stat3 adenovirus partly suppressed the growth of pancreatic cancer cells on day 4 post-inoculation (P<0.05) but not the expression of these mRNAs. 14580692 Human
stat3 pancreatic cancer These results indicate that activation of the JAK/Stat3 signaling pathway plays an important role in the progression of pancreatic cancer and that blockade of JAK/Stat3 signals may provide a novel therapeutic strategy for pancreatic cancer. 14580692 Human
stat3 cancer Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. 14659041 Human
stat3 cancer Stat3 is an oncogene that is activated in many human cancer cells. 14659041 Human
stat3 cancer Genetic approaches that disrupt Stat3 activity result in inhibition of cancer cell growth and enhanced cell apoptosis supporting the development of novel drugs targeting Stat3 for cancer therapy. 14659041 Human
stat3 cancer We demonstrated that the G-rich ODN T40214, which forms a G-quartet structure at intracellular but not extracellular K+ ion concentrations, is delivered efficiently into the cytoplasm and nucleus of cancer cells where it inhibited IL-6-stimulated Stat3 ac 14659041 Human
stat3 cancer Thus, G-quartet represents a new class of drug for targeting of Stat3 within cancer cells. 14659041 Human
stat-3 human breast cancer Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. 9041204 Human
stat-3 breast cancer Constitutively tyrosine-phosphorylated STAT-3 homodimers were also detected in another breast cancer cell line, MDA468, which has an EGFR amplification and also has constitutive EGFR activity. 9041204 Human
stat-3 human breast cancer Thus, SUM-102PT is a new human breast cancer cell line that expresses activated EGFR as a result of an autocrine/juxtacrine interaction with HB-EGF which, in turn, results in activation of STAT-3. 9041204 Human
aprf human hepatoma Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes. 9094433 Human
stat3 human hepatoma Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes. 9094433 Human
stat3 hepatoma Here we show that incubation of human hepatocytes as well as hepatoma cells (HepG2) with HGF/SF results in activation of the transcription factor STAT3. 9094433 Human
stat3 glioma In contrast, IL-10 failed to induce STAT3 in glial cells, but elicited a weak increase in STAT1 phosphorylation in microglia and C6-2B glioma cells only, suggesting that in some glial cell population(s) IL-10 may produce cellular responses via activation 9106258 Human
stat3 kaposis sarcoma Enhancement of gp130-mediated tyrosine phosphorylation of STAT3 and its DNA-binding activity in dexamethasone-treated AIDS-associated Kaposi's sarcoma cells: selective synergy between dexamethasone and gp130-related growth factors in Kaposi's sa 9164976 Human
stat3 hepatoma Ectopic expression and activation of wild-type STAT3 or STAT3SA in HepG2 hepatoma cells similarly enhance transcription through the IL-6-response element of the HP promoter. 9169415 Human
stat3 mycosis fungoides Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. 9192639 Human
stat3 tumor Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. 9192639 Human
stat3 tumor In MF tumor cells, a slowly migrating isoform of Stat3, Stat3(sm), was found to be constitutively activated, i.e., (i) Stat3(sm) was constitutively phosphorylated on tyrosine residues, and tyrosine phosphorylation was not enhanced by growth factor stimula 9192639 Human
stat3 myeloid leukaemia Stimulation by IL-6 or LIF of murine myeloid leukaemia cells (M1 cells) induced SSI-1 mRNA expression which was blocked by transfection of a dominant-negative mutant of Stat3, indicating that the SSI-1 gene is a target of Stat3. 9202127 Human
stat3 hepatoma In HepG2 hepatoma cells, however, these truncated Stat3 forms transmit signals from the interleukin-6 signal transducer gp130 equally well as does full-length Stat3. 9234724 Human
stat3 neuroblastoma Soluble footpad extracts induced the same changes in NBFL neuroblastoma cells as LIF and CNTF, including increased vasoactive intestinal peptide mRNA, STAT3 dimerization, and DNA binding, and stimulation of transcription from the vasoactive intestinal pep 9374533 Human
stat3 pancreatic cancer Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. 14586404 Human
stat3 tumors Consistent with this observation in PDAC cell lines, we found that most PDAC tumor specimens (10 of 11) showed constitutive activation of STAT3 and that ErbB2 was readily detected in most of these tumors (nine of 11). 14586404 Human
stat3 tumor Consistent with this observation in PDAC cell lines, we found that most PDAC tumor specimens (10 of 11) showed constitutive activation of STAT3 and that ErbB2 was readily detected in most of these tumors (nine of 11). 14586404 Human
stat3 human esophageal carcinoma Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. 14586407 Human
stat3 chronic lymphocytic leukemia B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. 9399961 Human
stat3 leukemias Serine phosphorylation of STAT1 and STAT3 was seen occasionally in other leukemias, but it was a universal finding only in CLL. 9399961 Human
stat3 breast carcinoma Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. 9419415 Human
stat3 breast carcinoma We detected constitutive activation of Stat3 in five of nine breast carcinoma cell lines but not in normal breast epithelial cells. 9419415 Human
stat3 breast carcinoma Furthermore, experiments with an EGF receptor-specific inhibitor indicated that the constitutive activation of Stat3 in these breast carcinoma cell lines is not necessarily dependent on signaling through the EGF receptor, although EGF stimulation further 9419415 Human
stat3 acute leukemias Members of the Stat protein family (Stat1, Stat3 and Stat5) are constitutively activated in cells collected from some acute leukemias suggesting dysregulation of the Jak-Stat pathway. 9498707 Human
stat3 t-cell lymphoma We report here that both DNA binding activities and tyrosine phosphorylation of STAT3 and STAT5, but not STAT1, are constitutively enhanced in the mouse T cell lymphoma LSTRA, which is a well-characterized cell line that overexpresses Lck protein and exhi 9548458 Mouse
stat3 embryonal carcinoma Similarly, the complex of soluble mIL-11R and IL-11 was capable of mediating an IL-6-type signaling in cells that are naturally deficient in IL-11 response as shown by the activation of STAT1 and STAT3 in mouse embryonal carcinoma cells and human T cells. 8683127 Human
stat3 cancers Stat3 is a latent transcription factor that exhibits elevated activity in a variety of human cancers. 12639546 Human
stat3 m1 leukemia A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. 8670868 Human
stat3 tumors An examination of the IL-6 signal transduction pathway reveals that this pathway, as defined by activation of Stat3, is inducible by IL-6 in raf/myc tumors but constitutively activated in abl/myc tumors. 8758897 Mouse
stat3 human neuroblastoma Exposure of human neuroblastoma cells, BE(2)-C, first to tyrosine phosphatase inhibitors (either phenylarsine oxide or PTP inhibitor-2) prevented Jak1, STAT1 and STAT3 activation elicited subsequently by either CNTF or interferon-gamma. 12941469 Human
stat3 tumor Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. 12842895 Human
stat3 tumours Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. 12474230 Human
stat3 mantle-cell lymphoma Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. 12474230 Human
stat3 tumours The expression of the two phosphorylated (i.e. active) forms of STAT3, pSTAT3-tyr (phosphorylated at the tyrosine(705) residue) and pSTAT3-ser (phosphorylated at the serine(727) residue), was assessed in four MCL cell lines and 12 MCL tumours using wester 12474230 Human
stat3 tumours Immunofluorescence studies using four formalin-fixed, paraffin wax-embedded MCL tumours demonstrated cytoplasmic localization of STAT3, as opposed to the nuclear localization of the pSTAT3 species. 12474230 Human
stat3 tumours In conclusion, these findings provide evidence that STAT3 is constitutively activated in MCL, supporting the concept that STAT3 signalling may be important in the pathogenesis of these tumours. 12474230 Human
stat-3 human renal-cell carcinoma We found that leptin caused the tyrosine phosphorylation of several proteins in human renal cell carcinoma cells, ACHN cells, in which STAT-1, but neither STAT-3 nor STAT-5, was involved. 8941366 Human
stat3 non-hodgkins lymphoma Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. 12538484 Human
stat3 multiple myeloma Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. 12538484 Human
stat3 tumor We hypothesized that inhibitors of the STAT3 pathway would sensitize drug-resistant and endogenous cytokine-dependent NHL and MM tumor cells to the cytotoxic effects of chemotherapeutic drugs. 12538484 Human
stat3 tumor Thus, we investigated the effect of two chemical STAT3 pathway inhibitors, namely, piceatannol (JAK1/STAT3 inhibitor) and tyrphostin AG490 (JAK2/STAT3 inhibitor), on the tumor cells for sensitization to therapeutic drugs. 12538484 Human
stat3 tumor Altogether, these results demonstrate that STAT3 pathway inhibitors are a novel class of chemotherapeutic sensitizing agents capable of reversing the drug-resistant phenotype of cytokine-dependent tumor cells. 12538484 Human
stat3 metastasis Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 12545153 Human
stat3 human pancreatic cancer Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 12545153 Human
stat3 human pancreatic cancer Immunohistochemical studies have indicated that VEGF overexpression coincides with elevated Stat3 activation in human pancreatic cancer specimens. 12545153 Human
stat3 human pancreatic cancer In our study, more than 80% of the human pancreatic cancer cell lines used exhibited constitutively activated Stat3, with Stat3 activation correlated with the VEGF expression level. 12545153 Human
stat3 metastasis Blockade of activated Stat3 via ectopic expression of dominant-negative Stat3 significantly suppressed VEGF expression, angiogenesis, tumor growth, and metastasis in vivo. 12545153 Human
stat3 tumor Blockade of activated Stat3 via ectopic expression of dominant-negative Stat3 significantly suppressed VEGF expression, angiogenesis, tumor growth, and metastasis in vivo. 12545153 Human
stat3 metastasis These results indicate that Stat3 directly regulates VEGF expression and hence angiogenesis, growth, and metastasis of human pancreatic cancer, suggesting that Stat3 signaling may be targeted for treatment of pancreatic cancer. 12545153 Human
stat3 pancreatic cancer These results indicate that Stat3 directly regulates VEGF expression and hence angiogenesis, growth, and metastasis of human pancreatic cancer, suggesting that Stat3 signaling may be targeted for treatment of pancreatic cancer. 12545153 Human
stat3 human pancreatic cancer These results indicate that Stat3 directly regulates VEGF expression and hence angiogenesis, growth, and metastasis of human pancreatic cancer, suggesting that Stat3 signaling may be targeted for treatment of pancreatic cancer. 12545153 Human
stat3 breast cancer Supershift analysis suggests that Stat1 and possibly other members of the STAT family of signalling factors, including Stat3, are activated in breast cancer tissues. 7710952 Human
stat3 cancers Activated forms of STAT3 transcription factors are often found in various cancers and tumor cell lines, indicating that this signaling pathway is involved in tumorogenesis. 12438313 Human
stat3 tumor Activated forms of STAT3 transcription factors are often found in various cancers and tumor cell lines, indicating that this signaling pathway is involved in tumorogenesis. 12438313 Human
stat3 glioblastoma In this study, we show that upon IL-6 stimulation of glioblastoma cells, STAT3 does not activate the expression of the p21(waf1) gene, whereas the expression of the myc gene remains unaltered. 12438313 Human
stat3 gastric cancer Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. 12555068 Human
stat3 gastric cancer Western blot analysis and electrophoretic mobility shift assay showed that DIF-1 inhibited STAT3 activity in an MEK-ERK-dependent manner in gastric cancer cell lines, AGS and MKN28. 12555068 Human
stat3 kidney carcinoma GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. 12559950 Human
stat3 primary-effusion lymphoma Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. 12393476 Human
stat3 cancers Since constitutive STAT3 activation and survivin expression have been widely documented in different types of cancers, their linkage may extend to many malignancies and be critical to their pathogenesis. 12393476 Human
stat3 non-small-cell lung cancer We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells. 12565872 Human
stat3 node-negative breast cancer Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. 12576423 Human
stat3 tumors PURPOSE: Although a high frequency of tumors contain constitutively activated signal transducers and activators of transcription 3 (Stat3), its relationship to breast cancer and patient survival has not been determined in a large retrospective study of no 12576423 Human
stat3 breast cancer PURPOSE: Although a high frequency of tumors contain constitutively activated signal transducers and activators of transcription 3 (Stat3), its relationship to breast cancer and patient survival has not been determined in a large retrospective study of no 12576423 Human
stat3 tumors To further elucidate the role of Stat3 in breast cancers, the expression patterns of Stat3 and Phospho-tyrosine residue 705 (Tyr705) Stat3 were correlated with survival outcome and clinicopathological parameters in a large cohort of node-negative breast c 12576423 Human
stat3 breast cancers To further elucidate the role of Stat3 in breast cancers, the expression patterns of Stat3 and Phospho-tyrosine residue 705 (Tyr705) Stat3 were correlated with survival outcome and clinicopathological parameters in a large cohort of node-negative breast c 12576423 Human
stat3 node-negative breast cancer To further elucidate the role of Stat3 in breast cancers, the expression patterns of Stat3 and Phospho-tyrosine residue 705 (Tyr705) Stat3 were correlated with survival outcome and clinicopathological parameters in a large cohort of node-negative breast c 12576423 Human
stat3 breast cancer EXPERIMENTAL DESIGN: Immunohistochemical analysis of Stat3 and Phospho-Stat3 was performed on a breast cancer tissue microarray of 346 node-negative breast cancer specimens. 12576423 Human
stat3 node-negative breast cancer EXPERIMENTAL DESIGN: Immunohistochemical analysis of Stat3 and Phospho-Stat3 was performed on a breast cancer tissue microarray of 346 node-negative breast cancer specimens. 12576423 Human
stat3 tumors RESULTS: Positive Stat3 cytoplasmic expression was seen in 69.2% of tumors, and positive Phospho-Stat3 (Tyr705) cytoplasmic expression was seen in 19.6% of tumors. 12576423 Human
stat3 tumors However, 23.1% of tumors had positive Stat3 nuclear expression, and those patients had a significantly improved short-term survival (P = 0.0332) at 5 years of follow-up. 12576423 Human
stat3 node-negative breast cancer CONCLUSIONS: These findings support a role for Stat3 and Phospho-Stat3 (Tyr705) overexpression in node-negative breast cancer and provide initial evidence that Phospho-Stat3 (Tyr705) may be a marker for improved overall survival independent of other progn 12576423 Human
stat3 hepatoma Activation of signal transducer and activator of transcription-3 (Stat3) expression by interferon-gamma and interleukin-6 in hepatoma cells. 7488223 Human
stat3 human hepatoma We report that both IL-6 and interferon gamma (IFN gamma) up-regulate the expression of Stat3 on both mRNA and protein levels in rat and human hepatoma cells. 7488223 Human
stat3 granuloma This specific STAT3 deletion causes death of these mice within 4-6 weeks after birth with Crohn's disease-like pathogenesis in both the small and large intestine, including segmental inflammatory cell infiltration, ulceration, bowel wall thickening, 12571365 Mouse
stat3 gastrointestinal stromal tumors Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. 12894500 Human
stat3 tumor This study demonstrates that STAT3 is constitutively activated in GIST and JAK2 blockade leads to tumor growth inhibition and apoptosis indicating the involvement of the JAK/STAT signaling pathway in GIST cellular survival. 12894500 Human
stat3 tumor Because constitutively active STAT3 up-regulates antiapoptotic genes to promote tumor survival, its inhibition by GRIM-19 also demonstrates an antioncogenic effect exerted by biological therapeutics. 12867595 Human
stat3 melanoma Fluorescence imaging analysis of upstream regulators and downstream targets of STAT3 in melanoma precursor lesions obtained from patients before and after systemic low-dose interferon-alpha treatment. 12926238 Human
stat3 atypical nevi To explore clinical treatments that might interfere with and possibly prevent atypical nevus progression, a previous study documented that 3 months systemic low-dose interferon-alpha (IFN-alpha) treatment of patients with a clinical history of melanoma an 12926238 Human
stat3 atypical nevus To explore clinical treatments that might interfere with and possibly prevent atypical nevus progression, a previous study documented that 3 months systemic low-dose interferon-alpha (IFN-alpha) treatment of patients with a clinical history of melanoma an 12926238 Human
stat3 melanoma To explore clinical treatments that might interfere with and possibly prevent atypical nevus progression, a previous study documented that 3 months systemic low-dose interferon-alpha (IFN-alpha) treatment of patients with a clinical history of melanoma an 12926238 Human
stat3 atypical nevi Based upon this finding, we initiated a second study to determine whether systemic low-dose IFN-alpha treatment also impairs the expression of upstream regulators and downstream targets of STAT1 and STAT3 in atypical nevi. 12926238 Human
stat3 systemic anaplastic large cell lymphoma In addition to JAK, recent data suggest that STAT3 can also be activated by other proteins such as the aberrant fusion protein, NPM-ALK, which is expressed in a subset of systemic anaplastic large cell lymphoma (ALCL). 12934099 Human
stat3 human pancreatic cancer Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. 12949733 Human
stat3 human pancreatic cancer We therefore analyzed the expression and biologic significance of STAT3 in human pancreatic cancer cells. 12949733 Human
stat3 pancreatic cancer Functional inactivation of STAT3 was achieved by stable transfection of dominant-negative STAT3 constructs in 2 pancreatic cancer cell lines and confirmed by electrophoretic mobility shift assay and immunoblotting. 12949733 Human
stat3 ductal carcinoma RESULTS: Compared with nontransformed human pancreas, activated STAT3 is overexpressed in ductal carcinoma cells but not in ducts from chronic pancreatitis. 12949733 Human
stat3 tumor Functional inactivation of STAT3 resulted in significant inhibition of anchorage-dependent and -independent proliferation in vitro and reduced tumor growth in vivo. 12949733 Human
stat3 human pancreatic cancer CONCLUSIONS: On malignant transformation, activated STAT3 promotes cellular proliferation by acceleration of G(1)/S-phase progression and thereby contributes to the malignant phenotype of human pancreatic cancer. 12949733 Human
stat3 myeloma We recently showed that IL-6 efficiently activated both signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase 1/2 (ERK1/2) in CD45- myeloma cell lines, although CD45- cells failed to proliferate in response t 12953802 Human
stat3 myeloma In contrast, src family protein-tyrosine kinases (PTKs), the most important substrates for CD45 protein-tyrosine phosphatase (PTP) are found activated independently of STAT3 and ERK1/2 activation in CD45+ but not in CD45- myeloma cell lines. 12953802 Human
stat3 myeloma Therefore activation of both STAT3 and ERK1/2 is not sufficient for IL-6-induced proliferation of myeloma cells, which requires the src family kinase activation associated with CD45 expression. 12953802 Human
stat-3 hepatocellular carcinoma STAT-3 activity in chemically-induced hepatocellular carcinoma. 12957465 Human
stat-3 malignant tumours The signal transducer and activator of transcription (STAT)-3 regulates basic biological processes and it has been reported to be constitutively active in different types of malignant tumours. 12957465 Human
stat-3 liver tumours STAT-3 is active during the regenerative growth of the liver, but there are hardly any data about its presence in liver tumours. 12957465 Human
stat-3 hepatocellular carcinomas We investigated and found a high activity of STAT-3 using an electrophoretic mobility shift assay (EMSA) in chemically-induced rat hepatocellular carcinomas (HCCs). 12957465 Rat
stat-3 tumours Dexamethasone treatment downregulated both STAT-3 activity and cell proliferation in the tumours. 12957465 Human
stat-3 tumour Therefore, the activity of the STAT-3 signal transduction pathway seems to be required for the growth of HCCs and could be a potential new target for therapeutic trials of this tumour type. 12957465 Human
stat3 tumors In contrast, STAT3 was expressed in poorly differentiated tumors. 12963127 Human
stat3 cancer Stat3 signaling provides, therefore, a novel molecular target for manipulation of immune activation/tolerance, a central decision with profound implications in autoimmunity, transplantation, and cancer immunotherapy. 14499117 Human
stat3 human neuroblastoma CNTF or interleukin-6 induced an IFN-gamma STAT3 response in a variety of cells including SH-SY5Y human neuroblastoma, HMN-1 murine motor neuron hybrid cells, rat sympathetic neurons and human hepatoma HepG2 cells. 14511121 Human
stat3 human hepatoma CNTF or interleukin-6 induced an IFN-gamma STAT3 response in a variety of cells including SH-SY5Y human neuroblastoma, HMN-1 murine motor neuron hybrid cells, rat sympathetic neurons and human hepatoma HepG2 cells. 14511121 Human
stat3 hepatoma Further, H-35 hepatoma cells expressing gp130 receptor chimeras lacking either the SHP-2 docking site or the Box 3 STAT binding sites failed to enhance the IFN-gamma STAT3 response. 14511121 Human
stat3 prostate cancer Screening of the prostate cancer cell lines LNCaP, PC3 and DU145 allowed the mapping of specific regions where genome copy number appeared altered and led to the identification of two novel regions of complete loss at 17q21.31 (500 kb spanning STAT3) and 12606952 Human
acute-phase response factor human hepatoma We report here that the rat alpha 2-macroglobulin promoter is activated by IFN-gamma in human hepatoma (HepG2) cells and that the IFN-gamma response element maps to the same site previously defined as the acute-phase response element (APRE), which binds t 7509445 Human
aprf human hepatoma We report here that the rat alpha 2-macroglobulin promoter is activated by IFN-gamma in human hepatoma (HepG2) cells and that the IFN-gamma response element maps to the same site previously defined as the acute-phase response element (APRE), which binds t 7509445 Human
stat3 cancers Stat3 plays important roles in cell growth, anti-apoptosis and cell transformation, and is constitutively active in various cancers. 12628925 Human
stat3 cancer GRIM-19, a gene product related to interferon-beta- and retinoic acid-induced cancer cell death, was identified and demonstrated to interact with Stat3 in various cell types. 12628925 Human
stat3 tumor Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. 12629515 Human
stat3 cervical cancer Based on the above phenomenon combined with the concomitant increased tumor expression of IL-6 and VEGF in cervical cancer tissues, we conclude that IL-6 may promote cervical tumorigenesis by activating VEGF-mediated angiogenesis via a STAT3 pathway. 12629515 Human
stat3 tumor Based on the above phenomenon combined with the concomitant increased tumor expression of IL-6 and VEGF in cervical cancer tissues, we conclude that IL-6 may promote cervical tumorigenesis by activating VEGF-mediated angiogenesis via a STAT3 pathway. 12629515 Human
acute-phase response factor human hepatoma Interleukin-6 (IL-6) causes the rapid activation of the acute-phase response factor (APRF) in the liver of animals during acute inflammation and in cultured human hepatoma cells (HepG2) and induces the transcription of the acute-phase protein genes, e.g. 7519723 Human
aprf human hepatoma Interleukin-6 (IL-6) causes the rapid activation of the acute-phase response factor (APRF) in the liver of animals during acute inflammation and in cultured human hepatoma cells (HepG2) and induces the transcription of the acute-phase protein genes, e.g. 7519723 Human
stat3 nasopharyngeal carcinoma (npc) STAT3 and STAT5 are constitutively activated and nuclear in nasopharyngeal carcinoma (NPC) cells. 12634372 Human
stat3 papillary thyroid carcinomas Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. 12647789 Human
stat3 follicular adenomas Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. 12647789 Human
stat3 papillary thyroid carcinomas (ptc) STAT3 expression was observed in 12/12 (100%) papillary thyroid carcinomas (PTC) but in none of the follicular tumors. 12647789 Human
stat3 tumors STAT3 expression was observed in 12/12 (100%) papillary thyroid carcinomas (PTC) but in none of the follicular tumors. 12647789 Human
stat3 cancer JSI-124 suppressed the levels of phosphotyrosine STAT3 in v-Src-transformed NIH 3T3 cells and human cancer cells potently (IC(50) value of 500 nM in the human lung adenocarcinoma A549) and rapidly (complete inhibition within 1-2 h). 12649187 Human
stat3 lung adenocarcinoma JSI-124 suppressed the levels of phosphotyrosine STAT3 in v-Src-transformed NIH 3T3 cells and human cancer cells potently (IC(50) value of 500 nM in the human lung adenocarcinoma A549) and rapidly (complete inhibition within 1-2 h). 12649187 Human
stat3 tumor JSI-124 was highly selective for JAK/STAT3 and did not inhibit other oncogenic and tumor survival pathways such as those mediated by Akt, extracellular signal-regulated kinase 1/2, or c-Jun NH(2)-terminal kinase. 12649187 Human
stat3 human breast carcinoma Finally, JSI-124 (1 mg/kg/day) potently inhibited the growth in nude mice of A549 tumors, v-Src-transformed NIH 3T3 tumors, and the human breast carcinoma MDA-MB-468, all of which express high levels of constitutively activated STAT3, but it did not affec 12649187 Human
stat3 lung adenocarcinoma Finally, JSI-124 (1 mg/kg/day) potently inhibited the growth in nude mice of A549 tumors, v-Src-transformed NIH 3T3 tumors, and the human breast carcinoma MDA-MB-468, all of which express high levels of constitutively activated STAT3, but it did not affec 12649187 Human
stat3 tumors Finally, JSI-124 (1 mg/kg/day) potently inhibited the growth in nude mice of A549 tumors, v-Src-transformed NIH 3T3 tumors, and the human breast carcinoma MDA-MB-468, all of which express high levels of constitutively activated STAT3, but it did not affec 12649187 Human
stat3 melanoma JSI-124 also inhibited tumor growth and significantly increased survival of immunologically competent mice bearing murine melanoma with constitutively activated STAT3. 12649187 Mouse
stat3 tumor JSI-124 also inhibited tumor growth and significantly increased survival of immunologically competent mice bearing murine melanoma with constitutively activated STAT3. 12649187 Mouse
stat3 human hepatoma Different patterns of regulation of Tyr-phosphorylated STAT1 and STAT3 in human hepatoma Hep3B cells by the phosphatase inhibitor orthovanadate. 12667488 Human
stat3 head-and-neck cancer Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. 12640143 Human
stat3 squamous cell carcinoma of the head and neck The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck (SCCHN). 12640143 Human
stat3 cancers The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck (SCCHN). 12640143 Human
stat3 cancer To investigate the therapeutic potential of blocking Stat3 in cancer cells, we developed a transcription factor decoy to selectively abrogate activated Stat3. 12640143 Human
stat3 head-and-neck cancer Treatment of head and neck cancer cells with the Stat3 decoy inhibited proliferation and Stat3-mediated gene expression, but did not decrease the proliferation of normal oral keratinocytes. 12640143 Human
stat3 cancers Thus, disruption of activated Stat3 by using a transcription factor decoy approach may serve as a novel therapeutic strategy for cancers characterized by constitutive Stat3 activation. 12640143 Human
acute-phase response factor human hepatoma We show here that IL-6 triggers the rapid activation of a nuclear factor, termed acute-phase response factor (APRF), both in rat liver in vivo and in human hepatoma (HepG2) cells in vitro. 7678052 Human
aprf human hepatoma We show here that IL-6 triggers the rapid activation of a nuclear factor, termed acute-phase response factor (APRF), both in rat liver in vivo and in human hepatoma (HepG2) cells in vitro. 7678052 Human
stat 3 multiple myeloma Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. 12707028 Human
stat 3 multiple myeloma (mm) Recently, it was proposed that constitutively activated Stat 3 (Stat 3 phosphorylated) contributes to the pathogenesis of multiple myeloma (MM) by preventing apoptosis and inducing proliferation. 12707028 Human
stat 3 multiple myeloma (mm) The study aim was to investigate Stat 3 activation in a series of multiple myeloma (MM) cases and its effect on downstream targets such as the anti-apoptotic proteins Bcl-xL, Mcl-1, and Bcl-2, and the cell-cycle protein cyclin D1. 12707028 Human
stat3 hepatoma In addition, we demonstrate that IFN-alpha can significantly activate STAT3 in hepatoma cells, suggesting that this pathway plays a role in IFN-alpha signaling. 12717400 Human
stat3 prostate cancer Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. 12763015 Human
stat3 head and neck squamous cell carcinoma Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. 12782602 Human
stat3 squamous cell carcinoma (scc) The aberrant growth of head and neck squamous cell carcinoma (HNSCC) is often associated with the constitutive activation of signal-transducer-and-activator-of-transcription-3 (STAT3), which is believed to result from the persistent stimulation of EGF rec 12782602 Human
stat3 head and neck squamous cell carcinoma The aberrant growth of head and neck squamous cell carcinoma (HNSCC) is often associated with the constitutive activation of signal-transducer-and-activator-of-transcription-3 (STAT3), which is believed to result from the persistent stimulation of EGF rec 12782602 Human
stat3 cancer Immunodepletion studies suggested interleukin 6 (IL6) as the major autocrine/paracrine factor for STAT3 activation, which coincided with high levels of secretion of IL6 into the culture medium by these cancer cells. 12782602 Human
stat3 melanoma Changes at genomic, transcriptional and post-translational levels of G-proteins and protein kinases (Ras, B-Raf) and their transcription factor effectors (c-Jun, ATF2, Stat3 and NF-kappaB) affects TNF, Fas and TRAIL receptors, which play important roles i 12789291 Human
stat3 solid tumors Constitutive activation of Stat3 has been observed in solid tumors including head and neck squamous cell carcinoma. 12789269 Human
stat3 head and neck squamous cell carcinoma Constitutive activation of Stat3 has been observed in solid tumors including head and neck squamous cell carcinoma. 12789269 Human
stat3 cancer Stat3 activation in cancer has been associated with autocrine stimulatory loops and is believed to convey a growth advantage to cells. 12789269 Human
stat3 cancer We now demonstrate ligand-independent activation of Stat3 by high cell density in multiple cancer cell lines. 12789269 Human
stat3 human hepatoma GCs rapidly inhibited the leptin-induced STAT3 phosphorylation in a dose- and time-dependent manner, as assayed by Western blotting using anti-phosphospecific-STAT3 in human hepatoma cell lines (Huh7) transiently expressing long form leptin receptor. 14993217 Human
stat3 non-small cell carcinoma Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. 12833138 Human
stat3 nonsmall-cell lung cancer Here we demonstrate that multiple nonsmall cell lung cancer cell lines demonstrate constitutive Stat3 DNA-binding activity. 12833138 Human
stat3 lung cancer Treatment of A549 lung cancer cells with PD180970 or SU6656, both pharmacological inhibitors of Src-kinase, resulted in reduced Src and Stat3 activity, cell cycle arrest in G2, and reduced viability of cells accompanied by induction of apoptosis. 12833138 Human
stat3 nonsmall-cell lung cancers These results demonstrate a role of Stat3 in transducing survival signals downstream of tyrosine kinases such as Src, EGF-R, and c-Met, as well as cytokines such as IL-6, in human nonsmall cell lung cancers. 12833138 Human
stat3 hepatoma 15dPGJ(2) also attenuated IL-6-induced tyrosine phosphorylation of STAT1 and STAT3 in Hep3B hepatoma cells. 12847270 Human
stat3 nasopharyngeal carcinoma Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. 12865928 Human
stat3 tumours Constitutively activated signal transducers and activators of transcription (STAT) factors, in particular STAT1, STAT3 and STAT5, have been demonstrated in a variety of human tumours and cancer cell lines. 12865928 Human
stat3 cancer Constitutively activated signal transducers and activators of transcription (STAT) factors, in particular STAT1, STAT3 and STAT5, have been demonstrated in a variety of human tumours and cancer cell lines. 12865928 Human
stat3 tumour The results showed that constitutive activation of STAT3 and STAT5 was detected in the majority, 70.5 and 62.3%, respectively, of the 61 tumour specimens. 12865928 Human
stat3 squamous cell carcinoma of the head and neck The oncogene signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a wide variety of human cancers, including squamous cell carcinoma of the head and neck. 12873986 Human
stat3 cancers The oncogene signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a wide variety of human cancers, including squamous cell carcinoma of the head and neck. 12873986 Human
stat3 squamous cell carcinoma of the head and neck In squamous cell carcinoma of the head and neck, Stat3 activation is mediated by up-regulation of the autocrine ligand-receptor pair, tumor growth factor alpha and epidermal growth factor receptor (EGFR), resulting in cell growth and resistance to apoptos 12873986 Human
stat3 squamous carcinoma When delivered into squamous carcinoma cells, phosphopeptides spanning Y1068 and Y1086 were able to inhibit EGFR-stimulated Stat3 DNA binding activity and cell proliferation. 12873986 Human
stat3 neoplasia Our results demonstrate that the LIF-induced differentiation of IEM cells involves suppression of IEM-derived neoplasia and is associated with the specific activation of Stat3. 9570916 Human
stat3 neoplasia IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells. 11710966 Rat
stat3 neoplasia Since Erk/MAP kinases are known to inhibit the subsequent IL-6-induced STAT3 activation, the impaired activation of Erk/MAP kinases by IL-6 may contribute to the development of B cell neoplasia. 11556393 Human
stat-3 ibd We also discovered phosphorylated STAT-3 in the nucleus of the colonic epithelial cells in IBD mice. 15147344 Human
stat-3 ibd Therefore, the secretion of IL-6 from IEC may be one of the mechanisms of STAT-3 phosphorylation in IEC during the pathogenesis of IBD, and inhibition of IL-6 production by IEC may be beneficial in preventing IBD. 15147344 Mouse
stat3 mds CONCLUSION: These results suggest that the defective megakaryopoiesis in MDS is not caused by a lack of c-mpl and that STAT3 and STAT5 may contribute to the malignant phenotype of the leukemic cells. 11027834 Human
signal transducer and activator of transcription 3 astrocytomas STAT3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas. 13678425 Human
stat3 mf In MF tumor cells, a slowly migrating isoform of Stat3, Stat3(sm), was found to be constitutively activated, i.e., (i) Stat3(sm) was constitutively phosphorylated on tyrosine residues, and tyrosine phosphorylation was not enhanced by growth factor stimula 9192639 Human
stat3 aml We examined whether an abnormal expression of one of the four JAKs, STAT1, STAT3, STAT5, or the tyrosine phosphatase SHP-1, a negative regulator of this pathway, is associated with malignant transformation in AML. 10340405 NA
stat3 prostate tumors Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. 12438264 Human
stat3 prostate tumors Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors. 12438264 Human
stat3 gist In this study, we examined for the expression of the activated form of STAT3 [phospho-STAT3 (tyr 705)] in eleven cases of GIST by immunohistochemistry. 12894500 NA
stat3 gist This study demonstrates that STAT3 is constitutively activated in GIST and JAK2 blockade leads to tumor growth inhibition and apoptosis indicating the involvement of the JAK/STAT signaling pathway in GIST cellular survival. 12894500 NA
stat3 alcl In this study, we investigated the possible role of JAK in activating STAT3 in ALCL using two ALK-positive ALCL cell lines, Karpas 299 and SU-DHL-1. 12934099 NA
stat3 alcl In this study, we evaluated comprehensively STAT3 activation status in anaplastic large cell lymphoma (ALCL) cell lines and pretreatment ALCL tumors. 14506160 NA
stat3 astrocytomas STAT3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas. 13678425 Human
stat3 astrocytomas CONCLUSION: These results show that STAT3 is required for the survival of some astrocytomas. 13678425 NA
stat3 astrocytomas These studies suggest STAT3 siRNA could be a useful therapeutic agent for the treatment of astrocytomas. 13678425 NA
stat 3 aml We examined the phosphorylation of STAT 3 and STAT 5 at the tyrosine residues in AML samples in which MAP kinase activity had already been found. 9633897 NA

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