IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene STAT5A Ensembl ENSG00000126561 Chromosome 17 Start 37693091 End 37717484
Description Signal transducer and activator of transcription 5A [Source:UniProtKB/Swiss-Prot;Acc:P42229]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11366
     Entrez Gene : 6776
     UCSC : uc002hzj.1
     GeneCards : 11366
     RefSeq : NM_003152
     CCDS : CCDS11424.1
     Uniprot : P42229
     Interpro : P42229
     OMIM : 601511
     GeneTests : STAT5A
     CGAP : STAT5A
     PMID : 7719937

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.50 199 1 0.53 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16668 AD c.82A>G p.I28V Substitution - Missense Heterozygous 17:37695037-3769503718948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40458_at  -0.54  2.35e-4  8.73e-4  -0.59  6.14e-4  2.01e-3
 HG_U95  506_s_at  -0.77  1.02e-6  6.70e-6  -0.92  1.36e-5  6.63e-5
 HG_U133A  203010_at  -0.72  1.51e-32  2.78e-31  -2.96  1.17e-56  2.98e-56
 HG_U133_Plus2  203010_at  -0.32  2.01e-4  6.02e-4  -0.33  9.17e-4  1.78e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203010_at  0.51  5.61e-2  7.13e-1  -0.12  5.38e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40458_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Gene expression figure

        HG_U133A - 203010_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203010_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
stat5 primary tumors Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat5 tumor Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat5 cancers Extensive studies of primary tumors and tumor derived cell lines revealed that inappropriate activation of specific STATs (particularly of STAT3 and STAT5) occurs with high frequency in a wide variety of human cancers. 11896598 Human
stat5 melanoma We reported recently that the melanoma inducing EGFR-related receptor Xmrk specifically induces constitutive activation of STAT5 in fish melanoma cells. 11896598 others
stat5 solid tumours However, little is known about the role of STAT5 in solid tumours in general and its function in melanoma in particular. 11896598 Human
stat5 melanoma However, little is known about the role of STAT5 in solid tumours in general and its function in melanoma in particular. 11896598 Human
stat5 acute promyelocytic leukemia Recently, the human Stat5 gene was found to be translocated to the RARalpha gene in a patient with acute promyelocytic leukemia indicating that Stat5 might also play a role in cellular transformation. 11929749 Human
stat5 cancer In this review, we will: (a) explain the mechanisms of STAT activation in normal and malignant signaling; (b) summarize recent evidence for the critical role of constitutively activated Stat3 and Stat5 in oncogenesis; (c) identify candidate STAT target ge 11948098 Human
stat5 hematopoietic malignancies Stat5 activation has been primarily demonstrated in hematopoietic malignancies. 11973644 Human
stat5 tumor Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin. 15059889 Mouse
stat5 tumors In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter. 15059889 Mouse
stat5 chronic myeloid leukaemia Differences in BCL-X(L) expression and STAT5 phosphorylation in chronic myeloid leukaemia patients. 15089759 Human
stat5 blast crisis We found that increased transcription of BCL-X(L) gene was associated with phosphorylated STAT5 in the majority of blast crisis patients and in a few accelerated and chronic phase patients. 15089759 Human
stat5 breast tumor Continuous activation of Stat5 indicates a role of this transcription factor in normal, nonpregnant breast epithelial cells, and may shed new light on Stat5 involvement in breast tumor promotion. 11981045 Human
stat5a lymphomas Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. 12048235 Mouse
stat5a murine leukemia We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. 12048235 Human
stat5a lymphomas We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice. 12048235 Human
stat5a mammary cancer Loss of Stat5a delays mammary cancer progression in a mouse model. 12082622 Mouse
stat5a human breast cancers Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation. 12082622 Human
stat5a mammary adenocarcinomas Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation. 12082622 Mouse
stat5a adenocarcinomas In comparison to mice carrying two wild-type Stat5a alleles, hemizygous loss of the Stat5a allele reduced the number of mice with palpable tumors at 7 months of age (67% from 100%, P<0.05), resulted in smaller tumors at 7 months of age (3.8 cm3 from 7.6 c 12082622 Mouse
stat5a tumors In comparison to mice carrying two wild-type Stat5a alleles, hemizygous loss of the Stat5a allele reduced the number of mice with palpable tumors at 7 months of age (67% from 100%, P<0.05), resulted in smaller tumors at 7 months of age (3.8 cm3 from 7.6 c 12082622 Mouse
stat5a tumor In comparison to mice carrying two wild-type Stat5a alleles, hemizygous loss of the Stat5a allele reduced the number of mice with palpable tumors at 7 months of age (67% from 100%, P<0.05), resulted in smaller tumors at 7 months of age (3.8 cm3 from 7.6 c 12082622 Mouse
stat5a breast cancer Decreasing Stat5a activation levels could be a therapeutic approach for reducing survival of breast cancer cells. 12082622 Human
stat5 breast tumors Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors. 12147240 Human
stat5 hepatoma The present study suggests that regulation of GH receptor (GHR) levels in rat hepatoma cells by repeated GH stimulation determines GH responsiveness via the JAK2/STAT5 pathway. 12161450 Human
stat5a human breast cancer We report for the first time that SHP-2 physically associates with the signal transducer and activator of transcription-5a (Stat5a), an important mediator of PRLR signaling to milk protein gene activation, in the mouse mammary HC11 and the human breast ca 12060651 Human
signal transducer and activator of transcription-5a human breast cancer We report for the first time that SHP-2 physically associates with the signal transducer and activator of transcription-5a (Stat5a), an important mediator of PRLR signaling to milk protein gene activation, in the mouse mammary HC11 and the human breast ca 12060651 Human
signal transducer and activator of transcription 5a tumor Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. 12208876 Human
stat5a tumor In fact, STAT5a overexpression was found in most tumor cells of tested patients with classical HD, indicating a critical role for HD. 12208876 Human
stat5 breast cancer Experimental Design: In this study we have separately determined activation of STAT1, STAT3, and STAT5 by measuring their DNA binding activity and tyrosine phosphorylation in breast cancer tissue samples. 12374673 Human
stat5a carcinomas Genes showing increased expression in carcinomas by cDNA microarray analysis (and further validated by immunohistochemistry and western blot analysis) include cyclin D1, PDGF-A chain, retinol binding protein 1, prohibitin and the transcription factor STAT 12376462 Human
stat5 myeloid leukemia The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. 12411494 Human
stat5 chronic myelogenous leukemia Signal transducer and activator of transcription 5 (STAT5) is constitutively activated by BCR/ABL, the oncogenic tyrosine kinase responsible for chronic myelogenous leukemia. 12411494 Human
stat5 tumour The co-existence of JAK2 and phosphorylated-JAK2, and STAT5 and phosphorylated STAT5, all of which are involved in the mitogenic signalling of erythropoietin, was found frequently in tumour cells and capillary endothelial cells in the untreated blocks. 12419827 Mouse
stat5a canine mammary tumor Upon GH stimulation of the GHR-positive CMT-U335 canine mammary tumor cell line, the transcription factors STAT5A and STAT5B become phosphorylated on their tyrosine residues, which is likely to reflect the significance of mammary GH in vivo. 12431808 Human
stat5 schwannoma We also find that schwannomin inhibits Stat3 and Stat5 phosphorylation in the rat schwannoma cell line RT4. 12444102 Human
stat5 estrogen receptor-positive breast cancer The role of Stat5 in estrogen receptor-positive breast cancer. 12459712 Human
stat5 hematopoietic malignancies The role of Stat5 in breast cancer has not been established, although Stat5 is critical for some hematopoietic malignancies. 12459712 Human
stat5 breast cancer The role of Stat5 in breast cancer has not been established, although Stat5 is critical for some hematopoietic malignancies. 12459712 Human
stat5 er-positive breast cancer We have analyzed the role of Stat5 in the progression of ER-positive breast cancer cells such as T47D and MCF7 in which Stat5b is constitutively activated. 12459712 Human
stat5 er-positive breast cancer Our study indicates that targeting Stat5 may represent a new strategy to suppress estrogen receptor activity and induce apoptosis in Stat5-activated, ER-positive breast cancer. 12459712 Human
stat5 cutaneous t-cell lymphoma SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. 12543077 Human
stat5 insulinoma Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5). 11145745 Human
stat5 insulinoma Whereas GH- and PRL-regulated transcription of the insulin gene in insulinoma cells has been shown to depend on STAT5 (signal transducer and activator of transcription 5), the signaling pathways involved in GH/PRL-induced beta-cell replication are unknown 11145745 Human
stat5a cancers Accordingly, the equilibrium between STAT5B and STAT5A and their naturally occurring truncated forms may therefore play a key role in the etiology of certain cancers. 11205741 Human
stat5 nasopharyngeal carcinoma Immunohistochemical analyses of nasopharyngeal carcinoma tumors revealed that STAT3, STAT5, and STAT1 are constitutively activated in these tumors while STAT3 is constitutively activated in the malignant cells of Hodgkin's disease. 11222718 Human
stat5 tumors Immunohistochemical analyses of nasopharyngeal carcinoma tumors revealed that STAT3, STAT5, and STAT1 are constitutively activated in these tumors while STAT3 is constitutively activated in the malignant cells of Hodgkin's disease. 11222718 Human
stat5a canine mammary tumor Growth hormone induces tyrosyl phosphorylation of the transcription factors Stat5a and Stat5b in CMT-U335 canine mammary tumor cells. 11311850 Human
stat5 human leukemia TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease in a murine bone marrow transplant model. 11313480 Human
stat5 acute myeloid leukemia (aml) We have previously demonstrated that while constitutively active STAT proteins were detected in ten of 36 (28%) for STAT3 and eight of 36 (22%) for STAT5 in pretreatment samples from newly diagnosed acute myeloid leukemia (AML) patients, a significantly l 11337019 Human
stat5a tumor Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a. 11340297 Human
stat5a mycosis fungoides We show that Gab2 was transiently phosphorylated by tyrosine in human mycosis fungoides (MF) tumor T cells upon IL-2 stimulation and that SHP2 as well as Stat5a associated inducibly with Gab2. 11340297 Human
stat5a tumor We show that Gab2 was transiently phosphorylated by tyrosine in human mycosis fungoides (MF) tumor T cells upon IL-2 stimulation and that SHP2 as well as Stat5a associated inducibly with Gab2. 11340297 Human
stat5 rat insulinoma To assess the importance of the STAT motif in PRL induction of insulin gene transcription, we deleted the STAT5 consensus sequence in the rat insulin 1 promoter, cloned the truncated promoter upstream of the luciferase reporter gene, and transfected the c 11415999 Human
stat5 multiple myeloma Using TGFbeta-producing multiple myeloma tumor cells we demonstrate that tumor-derived TGFbeta can block IL-2-induced proliferation and STAT3 and STAT5 phosphorylation in T cells. 11418694 Human
stat5 tumor Using TGFbeta-producing multiple myeloma tumor cells we demonstrate that tumor-derived TGFbeta can block IL-2-induced proliferation and STAT3 and STAT5 phosphorylation in T cells. 11418694 Human
stat5 tumor Activating T cells with IL-15, which does not use the high affinity IL-2R, completely restored the ability of T cells to phosphorylate STAT3 and STAT5 when cultured with tumor cells. 11418694 Human
stat5 tumor Preincubation with IL-15 also restored the ability of T cells to respond to IL-2 by phosphorylating STAT3 and STAT5, and proliferating normally in the presence of tumor cells. 11418694 Human
stat5 m1 leukemia STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65. 11564778 Human
stat5 cutaneous t-cell lymphoma On testing cutaneous T cell lymphoma cell lines and skin lesions, we found that the transcription factors STAT2, STAT3, STAT5, and STAT6 (STAT, signal transducer and activator of transcription) were present in the nuclei of these cells and that the bindin 11564163 Human
stat-5 myelodysplastic syndrome Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. 11583024 Human
stat-5 acute leukaemia Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. 11583024 Human
stat-5 acute leukaemia In acute leukaemia, elevated basal activity of STAT-5 DNA binding appeared in 8/8 cases, which was independent of Epo or GM-CSF treatment. 11583024 Human
stat5 acute myeloid leukemia Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. 11753614 Human
stat5 acute myeloid leukemia (aml) In the present study, we examined the underlying mechanism, which causes the constitutive tyrosine phosphorylation of signal transducer and activator of transcription 5 (STAT5) in acute myeloid leukemia (AML) blasts. 11753614 Human
stat-5 breast cancer In this study, the expression level of IL-7, IL-7 receptor (IL-7R) and their downstream signalling molecules, including the Janus kinases (Jak-1 and Jak-3), phosphoinositide 3-kinase (PI3-K) and signal transducers and activators of transcription (Stat-5) 14962714 Human
stat-5 tumours The levels of expression of IL-7, IL-7R, Jak-1, Jak-3, PI3-K and Stat-5 were significantly higher in the most aggressive tumours. 14962714 Human
stat-5 breast cancer With the exception of Stat-5 expression, the transcript copies of IL-7 and all other signalling molecules were higher in patients with the worst prognoses (NPI3) and in patients who died from breast cancer after 72 months of follow-up. 14962714 Human
stat5 chronic myelogenous leukemia (cml) Inhibition of the Bcr-Abl kinase activity in Bcr-Abl-expressing cell lines and CD34(+) cells from chronic myelogenous leukemia (CML) patients induces apoptosis by suppressing the capacity of Stat5 to interact with the bcl-x promoter. 10727459 Human
stat5 leukemias These results indicate that constitutive activation of STAT5 is a secondary event in most leukemias. 10729993 Human
stat5 human leukemia STAT1 and STAT5 also are activated by TEL/ABL and TEL/JAK2 fusion proteins associated with human leukemia. 10812249 Human
stat5 leukemia Constitutive activation of STAT3 and/or STAT5 resulting in enhanced transcription of anti-apoptotic- cell-cycle progression genes is likely to contribute to the pathogenesis of various myeloid leukemia's. 10851050 Human
stat5 sezary syndrome Dysregulated expression of COOH-terminally truncated Stat5 and loss of IL2-inducible Stat5-dependent gene expression in Sezary Syndrome. 14695224 Human
stat5a tumors We demonstrate that the absence of Stat5a/b is not essential for the induction of lymphoid or myeloid tumors in vivo or on the ability to transform bone marrow cells in vitro. 10979977 Human
stat5 leukemia To begin to elucidate a biological role for CD123 in leukemia, primary AML samples were analyzed with respect to signal transduction activity in the MAPK, Akt, and Stat5 pathways. 11021753 Human
stat5 hematologic malignancies STAT5 is activated in a broad spectrum of human hematologic malignancies. 11030348 Human
stat5 breast cancer We first demonstrated that STAT5 and STAT3 could be activated by either hGH or hPRL in T-47D breast cancer cells. 11078803 Human
stat5 acute myeloid leukemia Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. 11090077 Human
stat5 prostate cancers Frequently, however, abnormal activity of certain STAT family members, particularly Stat3 and Stat5, is associated with a wide variety of human malignancies, including hematologic, breast, head and neck, and prostate cancers. 11426647 Human
stat5a mammary tumor In the presence of the activated epidermal growth factor receptor, deletion of Stat5a delayed initial hyperplasia and mammary tumor development by 6 weeks. 10547072 Human
stat5a hyperplasia In the presence of the activated epidermal growth factor receptor, deletion of Stat5a delayed initial hyperplasia and mammary tumor development by 6 weeks. 10547072 Human
stat5a human breast cancers Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. 14696092 Human
stat5a human breast cancers Very limited information is available, however, on the expression, tyrosine phosphorylation status and nuclear localization of Stat5a in human breast cancers. 14696092 Human
stat5a adenocarcinomas Stat5a was nuclear localized and tyrosine phosphorylated in 59 of 78 (76%) breast cancers examined; 38 of 78 (49%) demonstrated Stat5a nuclear localization in more than 25% of the breast cancer cells within the adenocarcinomas. 14696092 Human
stat5a breast cancer Stat5a was nuclear localized and tyrosine phosphorylated in 59 of 78 (76%) breast cancers examined; 38 of 78 (49%) demonstrated Stat5a nuclear localization in more than 25% of the breast cancer cells within the adenocarcinomas. 14696092 Human
stat5a breast cancers Stat5a was nuclear localized and tyrosine phosphorylated in 59 of 78 (76%) breast cancers examined; 38 of 78 (49%) demonstrated Stat5a nuclear localization in more than 25% of the breast cancer cells within the adenocarcinomas. 14696092 Human
stat5a lymph-node metastases No relationship was found between nuclear localized Stat5a and menopausal status, tumor size, ploidy, percentage of cells in S-phase, lymph node metastases, ER, ErbB2, nuclear localized p21 or nuclear localized Stat5b/Stat3. 14696092 Human
stat5a tumor No relationship was found between nuclear localized Stat5a and menopausal status, tumor size, ploidy, percentage of cells in S-phase, lymph node metastases, ER, ErbB2, nuclear localized p21 or nuclear localized Stat5b/Stat3. 14696092 Human
stat5a breast cancer As its role in human breast cancer progression and response to therapy is defined, Stat5a could become a new molecular target for breast cancer therapy. 14696092 Human
stat5a human breast cancer As its role in human breast cancer progression and response to therapy is defined, Stat5a could become a new molecular target for breast cancer therapy. 14696092 Human
stat5a rhabdomyosarcoma Insulin selectively activates STAT5b, but not STAT5a, via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells. 10618497 Human
stat5a rhabdomyosarcoma We conclude from this rhabdomyosarcoma model that STAT5b, but not STAT5a is a direct target of the insulin receptor kinase. 10618497 Human
stat5a lymphomas Svi3 lymphomas had more mature phenotypes in the steps of early B-cell differentiation than Svi1 lymphomas, in which c-myc expression was indirectly up-regulated by provirus integration into Stat5a. 12967477 Human
stat-5 breast cancer Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro. 9888458 Human
stat5 leukemia Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 10209040 Human
stat5a chronic myelogenous leukemia (cml) METHODS: Chronic myelogenous leukemia (CML) cell lines or control Bcr/Abl-negative cells were treated or not with imatinib mesylate, fixed and permeabilized with formaldehyde followed by methanol; reacted with rabbit polyclonal and mouse monoclonal antibo 12879454 Human
stat5 adult t-cell lymphoma leukemia (atll) To determine activation status of the IL-2R-associated (Jak/STAT) pathway in the HTLV-I infected cells, we examined tyrosine phosphorylation of Jak3, STAT3, and STAT5 in several HTLV-I(+) T-cell lines and in uncultured leukemic T cells isolated from patie 10229324 Human
stat5 lymphoma Short term incubation (<60 min) of prolactin-responsive Nb2 lymphoma cells at high density selectively blocked prolactin stimulation of p42/p44 mitogen-activated protein kinases and transcription factors Stat1 and Stat3 but not prolactin activation of Sta 10329665 Human
stat5 melanoma The critical component of this complex, which directs transcriptional activation in the melanoma cells, proved to be a fish homologue of STAT5. 10366420 Human
stat5 leukemia STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. 10419904 Human
stat5 human breast cancer In addition, in human breast cancer cell T-47D, 20K-hGH was proved to stimulate Stat5 tyrosine phosphorylation to much lower degree than 22K-hGH via not hGHR but hPRLR. 10465259 Human
stat5 erythroleukemia These findings clearly indicate that the FVp gp55-EPOR signaling is distinct from the EPO-EPOR signaling and suggest that STAT5 may not play an essential role in the transmission of the cell growth signals in FVp gp55-induced erythroleukemia cells. 9488432 Human
stat5 hepatoma Continuous exposure to GH of BRL-4 cells, a rat hepatoma cell line stably transfected with rat GH receptor, induces a rapid but transient activation of Jak2 and Stat5. 9528967 Human
stat5a m1 myeloid leukemia Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells. 9606990 Human
stat5a m1 myeloid leukemia Treatment of M1 myeloid leukemia cells with leukemia inhibitory factor (LIF) causes activation of transcription factors Stat1, Stat3 and Stat5a (signal transducers and activators of transcription). 9606990 Human
stat5 t-cell lymphoma Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine. 9613985 Human
stat5 melanoma Signalling by the oncogenic receptor tyrosine kinase Xmrk leads to activation of STAT5 in Xiphophorus melanoma. 9662338 Human
stat5 melanoma In these cells as well as in Xiphophorus melanoma expression of pim-1 and constitutive DNA-binding activity of STAT5 was detectable. 9662338 Human
stat5 tumors This constitutive activity was higher in malignant than in benign melanomas, indicating that STAT5 activation is correlated with the malignancy of these tumors. 9662338 Human
stat5 benign melanomas This constitutive activity was higher in malignant than in benign melanomas, indicating that STAT5 activation is correlated with the malignancy of these tumors. 9662338 Human
stat5 acute myeloid leukemia (aml) Recently, constitutively activated Stat1, Stat3, and Stat5 were identified in nuclear extracts of acute myeloid leukemia (AML) patients, suggesting involvement of constitutive Stat activity in the events of leukemogenesis. 9694725 Human
stat 5 leukemia We conclude that all human TEL/JAK2 fusion variants are oncoproteins in vitro that strongly activate STAT 5, and cause lethal myelo- and lymphoproliferative syndromes in murine bone marrow transplant models of leukemia. 9736611 Human
stat5 acute myeloid leukemia Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. 12796379 Human
stat5a breast cancer We now show that progestin treatment of breast cancer cells regulates Stat5a and 5b, Stat3, and Stat1 protein levels in a PR-dependent manner. 9813040 Human
stat5 breast cancer Functional data show that progestin pretreatment of breast cancer cells enhances the ability of prolactin to stimulate the transcriptional activity of Stat5 on a beta-casein promoter. 9813040 Human
stat5a lymphoid tumor Molecular ablation of Stat5a/b promoted apoptotic cell death in a significant population of primary PHA-activated T cells (72%) and lymphoid tumor cell line (e.g., YT; 74%) within 24 h, as assessed by 1) visualization of karyolytic nuclear degeneration an 14530308 Human
stat5a epithelial cancers Studies to date have not elucidated clear and distinct roles for Stat5genes (Stat5a and Stat5b) in human epithelial cancers. 14583472 Human
stat5a squamous cell carcinoma of the head and neck We analyzed the role of Stat5a/b isoforms in squamous cell carcinoma of the head and neck using expression and activation studies in human tissues and in a xenograft model after selective targeting. 14583472 Human
stat5a tumor In a xenograft model, blockade of Stat5b, but not Stat5a, using antisense oligonucleotides resulted in tumor growth inhibition and abrogation of Stat5 target genes in vivo. 14583472 Human
stat5 tumor In a xenograft model, blockade of Stat5b, but not Stat5a, using antisense oligonucleotides resulted in tumor growth inhibition and abrogation of Stat5 target genes in vivo. 14583472 Human
stat5 tumors In tissues from 33 individuals with head and neck cancer, Stat5 activation levels were correlated with progression to a malignant phenotype, where increased expression and phosphorylation of Stat5b were detected consistently in tumors compared with their 14583472 Human
stat5 head-and-neck cancer In tissues from 33 individuals with head and neck cancer, Stat5 activation levels were correlated with progression to a malignant phenotype, where increased expression and phosphorylation of Stat5b were detected consistently in tumors compared with their 14583472 Human
stat5a breast adenocarcinoma To search for proteins that interact with the C terminus of Stat5a, a highly divergent region amongst Stat family members, we performed a yeast two-hybrid screen of HBL100 and primary breast adenocarcinoma libraries. 12198240 Human
stat5 myelodysplastic syndrome Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome. 9057652 Human
stat5 lymphoma Initial studies of STAT5 translocation were performed using PRL-dependent Nb2 lymphoma cells, in which PRL treatment resulted in a nearly complete translocation of cytoplasmic STAT5 to the nucleus. 9075720 Human
stat5 erythroleukemia STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line. 9079629 Human
stat5 megakaryoblastic leukemia Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5. 9111365 Human
stat5 hepatoma The signaling by endogenous LIF and OSM receptors differed from that by IL-6R by the prominent activation of STAT5 as shown in the mouse hepatoma cell line, Hepa-1. 9182534 Human
stat5 erythroleukemia JAK1 and STAT5 were constitutively tyrosine-phosphorylated but the DNA binding activity of STAT5 was not induced without EPO stimulation in erythroblastoid cells from spleens of F-SFFV-infected mice and erythroleukemia cell lines derived from gp55-transge 9209415 Human
stat5a m1 myeloid leukemia Here we report that leukemia inhibitory factor (LIF) and IL-6 activate Stat5a in M1 myeloid leukemia cells in addition. 9240457 Human
stat5a human hepatoma Transfection of an expression construct for Stat5a in human hepatoma cells caused a dose-dependent increase in LIF-triggered transcriptional activity. 9240457 Human
stat5a myeloid leukaemia Induction of differentiation by IL-6-type cytokines is impaired in myeloid leukaemia cells unable to activate Stat5a. 9325012 Human
stat5 acute leukemias Members of the Stat protein family (Stat1, Stat3 and Stat5) are constitutively activated in cells collected from some acute leukemias suggesting dysregulation of the Jak-Stat pathway. 9498707 Human
stat5 t-cell lymphoma We report here that both DNA binding activities and tyrosine phosphorylation of STAT3 and STAT5, but not STAT1, are constitutively enhanced in the mouse T cell lymphoma LSTRA, which is a well-characterized cell line that overexpresses Lck protein and exhi 9548458 Mouse
stat5a leukemia By using specific antisera, we demonstrated that both Stat5A and Stat5B are activated by interleukin-2 (IL-2) in peripheral blood lymphocytes, natural killer-like YT leukemia cells, and human T cell lymphotropic virus type I-transformed MT-2 T cells. 8631883 Human
stat5 leukemia Phosphorylation of STAT1 and STAT5 was also observed in the human leukemia cell lines K562 and BV173, which express the Bcr/Abl oncogene, but not in several Bcr/Abl-negative leukemia cell lines. 8642285 Human
stat5 human leukemia Phosphorylation of STAT1 and STAT5 was also observed in the human leukemia cell lines K562 and BV173, which express the Bcr/Abl oncogene, but not in several Bcr/Abl-negative leukemia cell lines. 8642285 Human
stat5 acute leukemia Confocal microscopy revealed the nuclear localization of Stat5 and Western blot analyses showed tyrosine phosphorylation of Stat5 in nuclear extracts of acute leukemia cells. 8704235 Human
stat5 chronic myelogenous leukemia Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. 8710363 Human
stat5 acute lymphoblastic leukemia Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. 8709637 Human
stat5 human erythroleukemia Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. 8861946 Human
stat-5 human renal-cell carcinoma We found that leptin caused the tyrosine phosphorylation of several proteins in human renal cell carcinoma cells, ACHN cells, in which STAT-1, but neither STAT-3 nor STAT-5, was involved. 8941366 Human
stat 5 breast cancer However, increased CIS expression in breast cancer lines appears to be a specific lesion, and could simultaneously shut down STAT 5 signalling by trophic hormones, confer resistance to host cytokines and increase proliferation through ERK kinases. 12888825 Human
stat5 nasopharyngeal carcinoma (npc) STAT3 and STAT5 are constitutively activated and nuclear in nasopharyngeal carcinoma (NPC) cells. 12634372 Human
stat5 breast cancer Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. 12642867 Human
stat5 breast cancer The role of Stat5 in breast cancer has not been established, although Stat5 is critical for some hematopoietic malignancies. 12642867 Human
stat5 hematopoietic malignancies The role of Stat5 in breast cancer has not been established, although Stat5 is critical for some hematopoietic malignancies. 12642867 Human
stat5 human breast cancer We detected for the first time that Stat5b is constitutively activated in human breast cancer cell lines, and analysed the role of Stat5 in estrogen receptor(ER)-positive breast cancer cell lines using dominant-negative variants of Stat5. 12642867 Human
stat5 breast cancer We detected for the first time that Stat5b is constitutively activated in human breast cancer cell lines, and analysed the role of Stat5 in estrogen receptor(ER)-positive breast cancer cell lines using dominant-negative variants of Stat5. 12642867 Human
stat5 breast cancer The present study indicates that overexpression of a dominant-negative variant of Stat5 suppresses ER transcriptional activity and induces apoptosis in estrogen-responsive breast cancer tissue culture cells. 12642867 Human
stat5 cancers This novel mechanism of transactivation by STAT5 provides a rationale for the use of deacetylase inhibitors for therapeutic intervention in STAT5-associated cancers. 12773560 Human
stat5 tumours To determine whether the Epo-EpoR pathway operates in tumours of these cell lines, we transplanted several cell lines into nude mice and confirmed the presence of Epo-responsive sites in xenografts in which the phosphorylation of the STAT5 (signal transdu 12807756 Human
stat5 melanoma Furthermore, in nude mice we blocked the Epo signalling in xenografts of two representative cell lines, stomach choriocarcinoma and melanoma, by i.p. injections of EpoR antagonist and found inhibition of angiogenesis and survival of tumour cells leading t 12807756 Human
stat5 choriocarcinoma Furthermore, in nude mice we blocked the Epo signalling in xenografts of two representative cell lines, stomach choriocarcinoma and melanoma, by i.p. injections of EpoR antagonist and found inhibition of angiogenesis and survival of tumour cells leading t 12807756 Human
stat5 tumour Furthermore, in nude mice we blocked the Epo signalling in xenografts of two representative cell lines, stomach choriocarcinoma and melanoma, by i.p. injections of EpoR antagonist and found inhibition of angiogenesis and survival of tumour cells leading t 12807756 Human
stat5 breast cancer We retrospectively analyzed whether levels of active Stat5 in breast cancer were linked to clinical outcome. 15169792 Human
stat5 breast cancer MATERIALS AND METHODS: Immunohistochemistry was used to detect active, tyrosine-phosphorylated Stat5 in paraffin-embedded breast cancer specimens from three archival tissue microarray materials A, B, and C. 15169792 Human
stat5 cancer RESULTS: Material A demonstrated that Stat5 activation, but not Stat5 protein expression, was gradually lost during cancer progression, with detectable activation in 100% of healthy breast specimens compared with less than 20% of node-positive breast canc 15169792 Human
stat5 metastases RESULTS: Material A demonstrated that Stat5 activation, but not Stat5 protein expression, was gradually lost during cancer progression, with detectable activation in 100% of healthy breast specimens compared with less than 20% of node-positive breast canc 15169792 Human
stat5 node-positive breast cancers RESULTS: Material A demonstrated that Stat5 activation, but not Stat5 protein expression, was gradually lost during cancer progression, with detectable activation in 100% of healthy breast specimens compared with less than 20% of node-positive breast canc 15169792 Human
stat5 tumors Stat5 activation in tumors of material B was associated with favorable prognosis. 15169792 Human
stat5 tumor Stat5 activation remained an independent prognostic marker after adjusting for patient age, tumor size, histological grade, estrogen receptor, progesterone receptor, and Her2/neu status by Cox multivariate analysis (hazard ratio, 2.0; P =.029). 15169792 Human
stat5 lymph node-negative breast cancer Stat5 activation was a particularly favorable marker in the lymph node-negative breast cancer subpopulation (hazard ratio, 7.5; P =.003). 15169792 Human
stat5 breast cancer CONCLUSION: In our study, active Stat5 distinguishes breast cancer patients with favorable prognosis, and may be a useful marker for selection of more individualized treatment, especially in localized disease. 15169792 Human
stat5a acute myeloid leukaemia (aml) The aim of this study was to evaluate the influence of suppression of STAT5A and STAT5B expression on the clonogenicity and apoptosis of the chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells. 15128421 Human
stat5a chronic myeloid leukaemia (cml) The aim of this study was to evaluate the influence of suppression of STAT5A and STAT5B expression on the clonogenicity and apoptosis of the chronic myeloid leukaemia (CML) and acute myeloid leukaemia (AML) cells. 15128421 Human
stat5 idiopathic myelofibrosis Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression. 12842707 Human
stat5 lymphoblastic lymphoma Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. 12835478 Human
stat5a t-cell lymphoblastic lymphomas We now report the development of thymic T cell lymphoblastic lymphomas in transgenic mice in which Stat5a or Stat5b is overexpressed within the lymphoid compartment. 12835478 Human
stat5 t-cell lymphomas Remarkably, the Stat5 transgene potently induced development of CD8+ T cells, even in mice expressing a class II-restricted TCR transgene, with resulting CD8+ T cell lymphomas. 12835478 Human
stat5 human prostate cancer Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. 12719422 Human
stat5 human prostate cancer We now report prevalent activation of transcription factor Stat5 in human prostate cancer and provide novel evidence that blocking activation of Stat5 in human prostate cancer cells leads to extensive cell death. 12719422 Human
stat5 human prostate cancer Specifically, Stat5 was activated in 65% of human prostate cancer specimens examined based on nuclear location of tyrosine phosphorylated Stat5. 12719422 Human
stat5 androgen-independent human prostate cancer Adenoviral gene delivery of a dominant-negative Stat5 mutant (DNStat5), but not wild-type Stat5, induced cell death of both the androgen-independent human prostate cancer cell line CWR22Rv and the androgen-sensitive LnCap cell line. 12719422 Human
stat5 prostate cancer We propose that blocking Stat5 function may represent a novel therapeutic approach for prostate cancer. 12719422 Human
stat5 nasopharyngeal carcinoma Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. 12865928 Human
stat5 tumours Constitutively activated signal transducers and activators of transcription (STAT) factors, in particular STAT1, STAT3 and STAT5, have been demonstrated in a variety of human tumours and cancer cell lines. 12865928 Human
stat5 cancer Constitutively activated signal transducers and activators of transcription (STAT) factors, in particular STAT1, STAT3 and STAT5, have been demonstrated in a variety of human tumours and cancer cell lines. 12865928 Human
stat5 tumour The results showed that constitutive activation of STAT3 and STAT5 was detected in the majority, 70.5 and 62.3%, respectively, of the 61 tumour specimens. 12865928 Human
stat5 mds CONCLUSION: These results suggest that the defective megakaryopoiesis in MDS is not caused by a lack of c-mpl and that STAT3 and STAT5 may contribute to the malignant phenotype of the leukemic cells. 11027834 Human
stat-5 mds We analysed Epo and GM-CSF induced ERK1/2 activation, c-Fos expression, STAT-5 and AP-1 DNA binding activities in mononuclear cells of umbilical cord blood (UCBMNC), normal marrow (NBMMNC) or marrow with MDS, AML with prior MDS and de novo AML. 11583024 Human
stat-5 mds These results suggest that impaired ERK/MAPK activation, similarly to impaired STAT-5 activation in Epo-R signalling, may be responsible for the apoptotic process and the block of maturation in MDS RA. 11583024 Human
stat5 mds Epo-signaling pathways (STAT5, Akt, and ERK 1/2) were normally activated in MDS erythroid progenitors. 11861273 Human
stat5 mds To investigate the functionality of Epo-R in MDS marrow, we focused on Epo-induced STAT5 activation. 10460607 Human
stat5 mds Epo was able to stimulate STAT5 DNA binding activity in all normal and 12/24 MDS marrows tested, with no correlation between the level of STAT5 activation and the development of erythroid colonies in response to Epo. 10460607 Human
stat5 mds In all 15 MDS samples tested, STAT5 activation was absent or greatly suppressed in response to Epo. 9057652 Human
stat5 mds In contrast, interleukin-3 induced a normal STAT5 response in MDS cells. 9057652 Human
mgf aml This study is now extended to the responses of freshly obtained AML cells and cell lines to the ligand, mast-cell growth factor (MGF). 1711640 NA
stat-5 aml We analysed Epo and GM-CSF induced ERK1/2 activation, c-Fos expression, STAT-5 and AP-1 DNA binding activities in mononuclear cells of umbilical cord blood (UCBMNC), normal marrow (NBMMNC) or marrow with MDS, AML with prior MDS and de novo AML. 11583024 NA
stat5 aml We examined whether an abnormal expression of one of the four JAKs, STAT1, STAT3, STAT5, or the tyrosine phosphatase SHP-1, a negative regulator of this pathway, is associated with malignant transformation in AML. 10340405 NA
stat 5 aml We examined the phosphorylation of STAT 3 and STAT 5 at the tyrosine residues in AML samples in which MAP kinase activity had already been found. 9633897 NA

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