IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene STK24 Ensembl ENSG00000102572 Chromosome 13 Start 97900456 End 98027397
Description Serine/threonine-protein kinase 24 (EC 2.7.11.1)(STE20-like kinase MST3)(MST-3)(Mammalian STE20-like protein kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y6E0]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11403
     Entrez Gene : 8428
     UCSC : uc001vnn.1
     GeneCards : 11403
     RefSeq : NM_001032296
     CCDS : CCDS9488.1
     Uniprot : Q9Y6E0
     Interpro : Q9Y6E0
     OMIM : 604984
     GeneTests : STK24
     CGAP : STK24
     PMID : 9353338

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.44 225 1 0.51 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17262 AD c.1241C>T p.A414V Substitution - Missense Heterozygous 13:97907477-9790747718948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40473_at  0.08  4.07e-1  5.14e-1  0.31  3.92e-3  1.02e-2
 HG_U133A  208854_s_at  0.38  4.20e-9  1.38e-8  -6.54  1.00e-140  2.35e-139
 HG_U133A  208855_s_at  0.04  4.05e-1  4.60e-1  1.65  4.95e-43  1.00e-42
 HG_U133A  215188_at  0.01  9.35e-1  9.45e-1  -1.84  3.45e-26  5.49e-26
 HG_U133_Plus2  208854_s_at  0.37  3.51e-6  1.45e-5  0.73  9.91e-13  6.03e-12
 HG_U133_Plus2  208855_s_at  0.40  5.32e-9  3.37e-8  0.58  5.41e-18  5.99e-17
 HG_U133_Plus2  215188_at  -0.25  3.57e-1  4.47e-1  0.12  5.59e-1  6.16e-1
 Stanford  11803  0.34  3.36e-1  5.37e-1  0.44  1.44e-1  3.47e-1
 Stanford  20842  0.11  6.67e-1  8.04e-1  0.34  3.01e-1  5.42e-1
 Stanford  22195  0.20  5.04e-1  6.85e-1  0.43  1.71e-1  3.86e-1
 Agilent_HS_21.6K  10957  -0.07  4.08e-1  5.93e-1  0.12  1.45e-1  2.72e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208854_s_at  0.20  3.43e-1  8.87e-1  -0.17  2.41e-1  1.00e+0
 HG_U133A  208855_s_at  0.30  1.22e-1  7.91e-1  -0.03  7.91e-1  1.00e+0
 HG_U133A  215188_at  -0.25  5.94e-1  9.51e-1  0.00  9.91e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40473_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208854_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208855_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215188_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208854_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208855_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215188_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11803    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20842    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22195    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10957    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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