IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SYK Ensembl ENSG00000165025 Chromosome 9 Start 92603891 End 92700652
Description Tyrosine-protein kinase SYK (EC 2.7.10.2)(Spleen tyrosine kinase) [Source:UniProtKB/Swiss-Prot;Acc:P43405]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11491
     Entrez Gene : 6850
     UCSC : uc004aqz.2
     GeneCards : 11491
     RefSeq : NM_001135052
     CCDS : CCDS6688.1
     Uniprot : P43405
     Interpro : P43405
     OMIM : 600085
     GeneTests : SYK
     CGAP : SYK
     PMID : 8082894

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Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
1 0.44 225 1 0.51 195 0 0.00 7
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
17170 AD c.1738G>C p.D580H Substitution - Missense Heterozygous 9:92690702-9269070218948947

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1630_s_at  0.09  3.83e-1  4.89e-1  0.23  1.25e-1  1.98e-1
 HG_U95  36885_at  0.01  9.40e-1  9.56e-1  0.32  5.73e-2  1.03e-1
 HG_U95  548_s_at  0.04  7.02e-1  7.79e-1  0.63  4.30e-5  1.87e-4
 HG_U133A  207540_s_at  0.10  4.50e-1  5.05e-1  -2.75  1.11e-51  2.61e-51
 HG_U133A  209269_s_at  -0.11  2.79e-1  3.31e-1  2.83  7.22e-93  4.04e-92
 HG_U133_Plus2  207540_s_at  -0.26  1.02e-2  2.08e-2  -0.06  5.98e-1  6.52e-1
 HG_U133_Plus2  209269_s_at  -0.64  7.06e-6  2.77e-5  -0.76  1.38e-5  3.46e-5
 HG_U133_Plus2  226068_at  -0.41  6.39e-6  2.53e-5  -0.28  6.93e-3  1.16e-2
 HG_U133_Plus2  244023_at  -0.82  1.42e-9  9.66e-9  -0.93  2.42e-9  9.84e-9
 Stanford  3747  -0.76  6.82e-2  1.92e-1  0.06  9.35e-1  9.72e-1
 Stanford  13310  -0.76  6.82e-2  1.92e-1  0.06  9.35e-1  9.72e-1
 Stanford  15919  -0.23  4.09e-1  6.05e-1  -0.49  1.60e-1  3.69e-1
 Agilent_HS_21.6K  18907  -0.09  6.84e-3  3.44e-2  -0.06  1.79e-1  3.17e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207540_s_at  0.51  1.35e-1  7.98e-1  -0.28  2.83e-1  1.00e+0
 HG_U133A  209269_s_at  0.18  6.00e-1  9.52e-1  -0.33  1.31e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1630_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36885_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 548_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207540_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209269_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207540_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209269_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 226068_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 244023_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3747    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13310    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15919    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18907    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
syk tumor Emerging evidence suggests that NK-activatory receptors use KARAP/DAP12, CD3zeta, and FcepsilonRIgamma adaptors that contain immunoreceptor tyrosine-based activatory motifs to mediate NK direct lysis of tumor cells via Syk tyrosine kinase. 11907067 Human
syk tumor Tumor cell ligation stimulated DAP12 tyrosine phosphorylation and its association with Syk in NK92 cells; Syk tyrosine phosphorylation and activation were also observed. 11907067 Human
syk rat basophilic leukemia Overexpression of Gab2 in rat basophilic leukemia 2H3 cell line cells inhibited the Fc epsilon RI-induced tyrosine phosphorylation of the subunits of the receptor, and the phosphorylation and/or activation of Syk and mitogen-activated protein kinase. 11971018 Rat
syk tumor Other signaling molecules, including the estrogen receptor, the tyrosine kinases c-Src and Syk, and STAT proteins, especially STAT3, have also been implicated in BC tumor growth. 11859072 Human
syk tumor Mouse splenic and thymic lymphocytes and tumor tissues were analyzed for the expression of cytokines involved in inflammatory and immune responses, including tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), basic fibroblast growth factor (bF 12072546 Mouse
syk rat basophilic leukemia We report in this study the successful targeting of the protein tyrosine kinase Syk in the RBL-2H3 rat basophilic leukemia cell line. 12193692 Rat
syk breast cancers It is now recognized that mutations in some tumor suppressor genes, such as p53, BRCA1, BRCA2, PTEN, or ATM, or epigenetic functional inactivation of other tumor suppressor genes, such as SYK and NES1, appear to play important early roles in the formation 12382187 Human
syk tumor It is now recognized that mutations in some tumor suppressor genes, such as p53, BRCA1, BRCA2, PTEN, or ATM, or epigenetic functional inactivation of other tumor suppressor genes, such as SYK and NES1, appear to play important early roles in the formation 12382187 Human
syk cancer These novel insights into the genomic organization, promoter structure and genetic variability of Syk will serve as a foundation for detailed molecular epidemiological investigation of its potential role in human cancer biology. 12400606 Human
syk nasal polyp In the present study, we examined whether Syk was expressed in a number of primary human nasal polyp tissue-derived fibroblast lines and whether it played some role in cellular function. 11123334 Human
syk nasal polyps These results suggest that Syk expression affects RANTES production in fibroblasts of nasal polyps. 11123334 Human
syk myelodysplastic syndrome The fusion of the TEL gene to the Syk gene in a patient with myelodysplastic syndrome (MDS) with t(9;12)(q22;p12) is reported. 11159536 Human
syk hematopoietic malignancies These data implicate that the rearranged Syk gene is involved in the pathogenesis of hematopoietic malignancies. 11159536 Human
syk embryonal carcinoma Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells. 11165236 Human
syk embryonal carcinoma Here we report that Syk is expressed in neuron-like cells and involved in neuron-like differentiation of embryonal carcinoma P19 cells. 11165236 Human
syk breast cancer Syk: a new player in the field of breast cancer. 11250739 Human
syk metastasis Recently, another tyrosine kinase, Syk, has been implicated as an important inhibitor of breast cancer cell growth and metastasis. 11250739 Human
syk breast cancer Recently, another tyrosine kinase, Syk, has been implicated as an important inhibitor of breast cancer cell growth and metastasis. 11250739 Human
syk human t-cell leukaemia Moreover, Syk was expressed on all human T-cell leukaemia virus (HTLV-1)-transformed T-cell lines derived from peripheral blood of the patient, whereas it was low or undetectable in control lines. 11412303 Human
syk nasal polyp We established the human fibroblast lines showing high Syk expression and the lines showing low Syk expression from pieces of nasal polyp. 11418661 Human
syk nasal polyps We concluded that Syk is required for the IL-1-induced chemokine production through the association with TRAF-6 in fibroblasts of nasal polyps. 11418661 Human
syk human breast cancer Hypermethylation leads to silencing of the SYK gene in human breast cancer. 11454707 Human
syk breast cancer SYK, a candidate tumor suppressor, has been found not expressed in a subset of breast cancer cell lines, but the mechanism by which SYK is silenced is unclear. 11454707 Human
syk tumor SYK, a candidate tumor suppressor, has been found not expressed in a subset of breast cancer cell lines, but the mechanism by which SYK is silenced is unclear. 11454707 Human
syk breast cancer In this study, we examined the 5' CpG island methylation status of the SYK gene in breast cancer cell lines and primary breast cancer tissues. 11454707 Human
syk primary breast cancer In this study, we examined the 5' CpG island methylation status of the SYK gene in breast cancer cell lines and primary breast cancer tissues. 11454707 Human
syk breast cancer We found SYK 5' CpG hypermethylation in 30% (6/20) of breast cancer cell lines, and the aberrant methylation status was strongly associated with loss of SYK gene expression. 11454707 Human
syk breast tumors Using methylation-specific PCR, we demonstrated that SYK is hypermethylated in 32% (12/37) of unselected breast tumors, whereas all of the matched neighboring normal breast tissues exhibited unmethylated DNA status. 11454707 Human
syk breast cancer We concluded that SYK is frequently inactivated through an epigenetic pathway in breast cancer. 11454707 Human
syk breast cancer Because SYK has been shown to function as a tumor suppressor, and its loss of expression in breast cancer has been correlated with tumor invasiveness, the aberrant SYK methylation is responsible for the loss of expression and may consequently play a permi 11454707 Human
syk tumor Because SYK has been shown to function as a tumor suppressor, and its loss of expression in breast cancer has been correlated with tumor invasiveness, the aberrant SYK methylation is responsible for the loss of expression and may consequently play a permi 11454707 Human
syk cancer Recent findings reveal that expression of Syk appears to be involved in a wide variety of cellular functions and pathogenesis of malignant cancer. 11481033 Human
spleen tyrosine kinase acute lymphoblastic leukemia Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. 11494125 Human
syk acute lymphoblastic leukemia Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. 11494125 Human
syk hematological malignancies Fusions of the ETV6/TEL gene to receptor or protein tyrosine kinases (TKs), such as PDGFRbeta, JAK2, ABL, ABL2, TRKC, and Syk, have been reported in various hematological malignancies. 11731410 Human
syk granulosa cell tumours Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin. 14970867 Human
syk tumours Hypermethylation of MGMT (in 14 tumours), CDH1 (in nine tumours), RAR-beta (in eight tumours) and SYK (in seven tumours) have been found. 14970867 Human
syk myelodysplastic syndrome We previously reported the fusion of the TEL gene to the Syk gene in myelodysplastic syndrome with t(9;12)(q22;p12). 14749700 Human
syk human breast cancer The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. 10963601 Human
syk breast cancer Here we show that Syk is commonly expressed in normal human breast tissue, benign breast lesions and low-tumorigenic breast cancer cell lines. 10963601 Human
syk invasive breast carcinoma Syk messenger RNA and protein, however, are low or undetectable in invasive breast carcinoma tissue and cell lines. 10963601 Human
syk metastasis Transfection of wild-type Syk into a Syk-negative breast cancer cell line markedly inhibited its tumour growth and metastasis formation in athymic mice. 10963601 Mouse
syk breast cancer Transfection of wild-type Syk into a Syk-negative breast cancer cell line markedly inhibited its tumour growth and metastasis formation in athymic mice. 10963601 Mouse
syk tumour Transfection of wild-type Syk into a Syk-negative breast cancer cell line markedly inhibited its tumour growth and metastasis formation in athymic mice. 10963601 Mouse
syk breast cancer Conversely, overexpression of a kinase-deficient Syk in a Syk-positive breast cancer cell line significantly increased its tumour incidence and growth. 10963601 Human
syk tumour Conversely, overexpression of a kinase-deficient Syk in a Syk-positive breast cancer cell line significantly increased its tumour incidence and growth. 10963601 Human
syk tumour Suppression of tumour growth by the reintroduction of Syk appeared to be the result of aberrant mitosis and cytokinesis. 10963601 Human
syk human breast carcinomas We propose that Syk is a potent modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. 10963601 Human
syk lymphocyte predominance hodgkin disease In contrast, the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn, Syk, BLNK, and PLC-gamma2, and Lyn immunostaining was seen in a minority of biopsies. 12881301 Human
syk tumor In contrast, the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn, Syk, BLNK, and PLC-gamma2, and Lyn immunostaining was seen in a minority of biopsies. 12881301 Human
syk myeloma Using a CD19 reconstituted myeloma model and CD19 gene-ablated animals we found that BCR-mediated Btk activation and phosphorylation are dependent on the expression of CD19, while BCR-mediated activation of Lyn and Syk is not. 10201980 Human
syk rat basophilic leukemia Syk and the mitogen-activated protein kinase extracellular signal-regulated kinase 1 (ERK1) were found to form a tight complex in both resting and Ag-stimulated rat mucosal-type mast cells (rat basophilic leukemia 2H3 cell line RBL-2H3). 10415002 Rat
syk b lymphoma Cross-linking of either class II molecules or the BCR on CD45-positive K46-17micromlambda B lymphoma cells was observed to induce activation of the Src family protein- tyrosine kinase Lyn, tyrosine phosphorylation of Syk and phospholipase Cgamma, and the 9565626 Human
syk rat basophilic leukemia Evidence for involvement of two isoforms of Syk protein-tyrosine kinase in signal transduction through the high affinity IgE receptor on rat basophilic leukemia cells. 9604011 Rat
syk rat basophilic leukemia A rat basophilic leukemia cell line, RBL-2H3, expresses similar levels of two Syk isoforms that differ with respect to the presence of a 23-amino acid insert within the "linker" region located between the second Src homology 2 and the catalytic 9604011 Rat
syk rat basophilic leukemia Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors. 9022035 Rat
syk cutaneous t-cell lymphoma Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk. 9264390 Human
syk b-cell lymphoma RESULTS: A mutant form of Syk carrying a combination of a K395A substitution in the kinase domain and substitutions of three phenylalanines (3F) for the three C-terminal tyrosines was expressed in a murine B cell lymphoma cell line, BCL1.3B3 to interfere 12470302 Mouse
syk myeloblastic leukemia Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193. 9395328 Human
syk rat basophilic leukemia Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells. 9464827 Rat
syk rat basophilic leukemia Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. 8691151 Rat
syk human breast cancer Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. 12445683 Human
syk breast cancer In 25 (28%) of the 90 paired samples of human breast cancer and the matched, adjacent non-cancerous tissues examined here, reduced mRNA expression of Syk in the breast cancer tissues was observed by real-time quantitative reverse transcription-polymerase 12445683 Human
syk human breast cancer In 25 (28%) of the 90 paired samples of human breast cancer and the matched, adjacent non-cancerous tissues examined here, reduced mRNA expression of Syk in the breast cancer tissues was observed by real-time quantitative reverse transcription-polymerase 12445683 Human
syk metastasis Eight (32%) of the 25 cases showing reduced Syk mRNA expression demonstrated distant metastasis of breast cancer, while only 4 (6%) of the 65 cases who did not show reduced Syk expression had distant metastasis. 12445683 Human
syk breast cancer Eight (32%) of the 25 cases showing reduced Syk mRNA expression demonstrated distant metastasis of breast cancer, while only 4 (6%) of the 65 cases who did not show reduced Syk expression had distant metastasis. 12445683 Human
syk metastasis Kaplan-Meier curves demonstrated that patients with reduced Syk expression were at significantly increased risk for distant metastasis (P=0.0003). 12445683 Human
syk metastasis Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis; therefore, Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human breast cancer. 12445683 Human
syk breast cancers Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis; therefore, Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human breast cancer. 12445683 Human
syk tumor Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis; therefore, Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human breast cancer. 12445683 Human
syk human breast cancer Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis; therefore, Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human breast cancer. 12445683 Human
syk breast cancer Perhaps the most interesting non-traditional role of Syk is that of a potential tumor suppressor in breast cancer. 15180536 Human
syk tumor Perhaps the most interesting non-traditional role of Syk is that of a potential tumor suppressor in breast cancer. 15180536 Human
syk breast tumors Absence of Syk protein in primary breast tumors is correlated with poor outcomes. 15180536 Human
syk rat basophilic leukemia Tyrosine-phosphorylated beta and gamma ITAM peptides immobilized on beads precipitated Syk, Lyn, Shc, Grb2, and phospholipase C-gamma1 from lysates of rat basophilic leukemia RBL-2H3 cells. 8910399 Rat
syk myeloma This Syk-Lyn interaction may be dependent on the stage of B-cell differentiation, since Syk-Lyn associations were not detected in pre-B and myeloma cell lines and Syk from an immature B-cell line did not reassociate with Lyn in vitro. 7831290 Human
syk rat basophilic leukemia Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells. 7532280 Rat
syk rat basophilic leukemia To test this possibility, Syk was introduced into a model mast cell line (rat basophilic leukemia cells) as part of a chimeric transmembrane protein containing the extracellular and transmembrane domains of CD16 and CD7, respectively. 7532280 Human
syk tumor In RBL-2H3 rat tumor mast cells, cross-linking the high affinity IgE receptor, Fc epsilon R1, activates the protein-tyrosine kinases Lyn and Syk and initiates a series of responses including protein-tyrosine phosphorylation, inositol 1,4,5-trisphosphate s 7876149 Rat
syk tumors Upregulated expression of syk was observed in aggressive, metastasizing mammary gland tumours but not in well differentiated, non-metastasizing tumors. 7639745 Human
syk tumours Upregulated expression of syk was observed in aggressive, metastasizing mammary gland tumours but not in well differentiated, non-metastasizing tumors. 7639745 Human
syk breast cancer Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells. 12477728 Human
spleen tyrosine kinase breast cancer Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer. 12907655 Human
syk breast cancer Loss of Syk expression through promoter hypermethylation is associated with increased invasiveness in a subset of breast cancer. 12907655 Human
syk breast cancer Here, we show that in addition to full-length Syk [Syk(L)], an alternatively spliced variant, Syk(S), is frequently expressed in breast cancer cells. 12907655 Human
syk tumor The correlation of the nuclear localization and invasion suppression function of Syk(L) indicated that nuclear Syk possesses biological activities associated with tumor suppression in mammary epithelial cells. 12907655 Human
syk basophilic leukemia Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812). 7513161 Human
syk basophilic leukemia We isolated two different sized cDNA clones of syk (Syk11 and Syk41) from a cDNA library of human KU812 (human basophilic leukemia cell line). 7513161 Human
syk rat basophilic leukemia Aggregation of the high affinity IgE receptor (Fc epsilon RI) on rat basophilic leukemia RBL-2H3 cells results in activation of the protein tyrosine kinases Syk and Lyn. 8071371 Rat
syk tumor In RBL-2H3 rat tumor mast cells, antigens that cross-link the high affinity cell surface IgE receptor, Fc epsilon R1, activate at least two receptor-associated protein-tyrosine kinases, Lyn and Syk, and cause the tyrosine phosphorylation of the receptor b 7961959 Rat
spleen tyrosine kinase t-lineage acute lymphoblastic leukemia Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia. 12717427 Human
syk t-lineage acute lymphoblastic leukemia MSP screening of leukemia cells from six T-lineage acute lymphoblastic leukemia (ALL) patients demonstrated methylation of the Syk promoter CpG island in one T-lineage ALL patient. 12717427 Human
syk rat basophilic leukemia As the actin cytoskeleton has been demonstrated to inhibit the early FcepsilonRI signaling in rat basophilic leukemia cells, we explored the hypothesis that the actin cytoskeleton was responsible for the transience of syk phosphorylation in antigen-stimul 14996825 Rat
spleen tyrosine kinase breast cancer BACKGROUND: Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer. 17214368 Human
syk cll We show that BCR-mediated activation of ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk. 17038529 Human
syk lymphoma We show that BCR-mediated activation of ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk. 17038529 Human
syk gastric adenocarcinoma In this study, the presence of the FcRgamma chain and its associated kinase, Syk, was analysed in patients with gastric adenocarcinoma and healthy subjects. 17134755 Human
syk nasal polyp Expression of Syk is associated with nasal polyp in patients with allergic rhinitis. 17141440 Human
syk polyps It has been hypothesized that Syk expression in allergic nasal mucosa and polyps with allergy is different from non-allergic mucosa, and that changes in Syk expression contribute to the activation of allergic reactions. 17141440 Human
syk polyps METHODS: We examined whether the expression of Syk is found in allergic nasal mucosa and polyps. 17141440 Human
syk polyps We investigated the expression of Syk in 46 nasal mucosa and polyps (14 samples from patients with allergic rhinitis and 32 samples with non-allergic chronic sinusitis) using an immunohistochemical technique. 17141440 Human
syk polyps RESULTS: Allergic polyps had more Syk positive cells than non-allergic polyps. 17141440 Human
syk invasive breast cancer Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness. 17214368 Human
syk breast cancer BACKGROUND: Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer. 17214368 Human
syk invasive breast cancer MATERIALS AND METHODS: Syk expression in patients with invasive breast cancer was immunohistochemically assessed. 17214368 Human
syk breast cancer CONCLUSION: Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer. 17214368 Human
syk lymphocyte predominance hodgkin disease In contrast, the tumor cells in all cases of lymphocyte predominance Hodgkin disease were positive for Fyn, Syk, BLNK, and PLC-gamma2, and Lyn immunostaining was seen in a minority of biopsies. 12881301 Human
spleen tyrosine kinase melanoma The current study was performed to assess the impact of "spleen tyrosine kinase" (Syk), a non-receptor-associated tyrosine kinase, on growth and metastatic behavior of melanoma cells in vitro and in a severe combined immunodeficient (SCID)-mouse 15955106 Mouse
syk mammary gland tumours Upregulated expression of syk was observed in aggressive, metastasizing mammary gland tumours but not in well differentiated, non-metastasizing tumors. 7639745 Human
syk pancreatic cancers [Expression of tyrosine kinase syk in pancreatic cancers] 11481871 Human
syk cll The Syk kinase, critical for transducing B-cell receptor (BCR)- derived signals, was constitutively present in all CLL samples, and there was a perfect association between global phosphorylation and induction of phosphorylation/activation of Syk. 12393552 Human
syk t-all In all nine T-ALL samples studied, the leukaemic cells showed a marked reduction in the expression of the zeta chain, while a variety of tyrosine kinases (p56lck, ZAP70 and SYK) were normally present. 12542476 Human
syk t-all The presence of a methylated promoter sequence in these T-lineage leukemia cell lines and in one T-lineage patient suggests a potential role for SYK as a tumor suppressor in T-ALL. 12717427 Human
syk aml The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression. 12763134 Human
syk aml Recently we reported that CD33 recruits Syk for its signaling in AML cell lines. 12763134 Human
syk aml In this study, we further investigated the mechanism(s) of Syk engagement in CD33 signaling in primary AML samples. 12763134 Human
syk aml Seven of 25 AML samples (28%) expressed undetectable levels of Syk. 12763134 Human
syk aml CONCLUSIONS: Syk is an important component in the regulation of proliferation in AML cells. 12763134 Human
syk aml The differential response of AML cells to CD33 ligation is associated with the level of the Syk expression. 12763134 Human
syk ovarian granulosa cell tumours Therefore, we assessed the promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK in 43 ovarian granulosa cell tumours (GCTs) (adult type) using methylation-specific PCR. 14970867 Human
syk breast carcinoma [Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma] OBJECTIVE: To investigate the relationship between methylation of syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metast 15059510 Human
syk metastasis [Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma] OBJECTIVE: To investigate the relationship between methylation of syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metast 15059510 Human
syk fibroadenoma No methylation of syk promoter was found in adjacent normal tissues and fibroadenoma samples, 17 cases in 40 breast carcinoma patients (42.5%) were detected hypermethylation of syk gene in promoter region, the rate of methylation of syk promoter in breast 15059510 Human
syk breast carcinoma No methylation of syk promoter was found in adjacent normal tissues and fibroadenoma samples, 17 cases in 40 breast carcinoma patients (42.5%) were detected hypermethylation of syk gene in promoter region, the rate of methylation of syk promoter in breast 15059510 Human
syk lymph-node metastasis In 18 cases with lymph node metastasis, 14 were found with syk promoter methylation. 15059510 Human
syk breast cancer [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
syk lymph-node metastasis Furthermore, only one breast cancer tissue in 18 patients with lymph node metastasis had the Syk mRNA expression, the rate and level of Syk mRNA expression in the patients with lymph node metastasis were lower than those without lymph node metastasis (chi 15062056 Human
syk gastric carcinoma Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. 15188513 Human
syk metastasis Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma. 15188513 Human
syk gastric carcinoma AIM: To investigate the relationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metastasis of gastric carcinoma. 15188513 Human
syk metastasis AIM: To investigate the relationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metastasis of gastric carcinoma. 15188513 Human
syk tumor METHODS: By using methylation-specific PCR (MSP) technique, the methylation of Syk promoter region in specimens from 61 gastric cancer patients (tumor tissues and adjacent normal tissues) was detected. 15188513 Human
syk gastric cancer METHODS: By using methylation-specific PCR (MSP) technique, the methylation of Syk promoter region in specimens from 61 gastric cancer patients (tumor tissues and adjacent normal tissues) was detected. 15188513 Human
syk gastric carcinoma Syk expression in gastric carcinoma was lower in 14 out of 61 gastric cancer samples than in adjacent normal tissues (chi(2)=72.3, P<0.05). 15188513 Human
syk gastric cancer Syk expression in gastric carcinoma was lower in 14 out of 61 gastric cancer samples than in adjacent normal tissues (chi(2)=72.3, P<0.05). 15188513 Human
syk gastric carcinoma The rate of methylation of Syk promoter in gastric carcinoma was higher than that in adjacent normal tissues (chi(2)=25.1, P<0.05). 15188513 Human
syk lymph-node metastasis In 31 patients with lymph node metastasis, 17 were found with Syk promoter methylation. 15188513 Human
syk b-chronic lymphocytic leukemia The interplay between Syk and ZAP-70 in thymocytes, certain T cells, and B-chronic lymphocytic leukemia cells, in which they are coexpressed, will therefore modulate the amplitude of antigen-mediated receptor signaling. 15059847 Human
syk embryonal carcinoma Importantly, tamalin was endogenously phosphorylated and associated with Syk in retinoic acid-treated P19 embryonal carcinoma cells that undergo neuron-like differentiation. 15173175 Human
syk necrosis In contrast, the stimulation with the millimolar concentrations of H(2)O(2) rapidly led to necrosis in which tyrosine phosphorylation of FAK was involved at the downstream of Lyn and Syk. 15032688 Human
syk breast cancer Progressive loss of Syk and abnormal proliferation in breast cancer cells. 15492255 Human
syk invasive breast cancer The tumor suppressor gene Syk tyrosine kinase is absent or reduced in invasive breast cancer tissues and cell lines; its loss in breast tissues is linked to poor prognosis and metastasis. 15492255 Human
syk metastasis The tumor suppressor gene Syk tyrosine kinase is absent or reduced in invasive breast cancer tissues and cell lines; its loss in breast tissues is linked to poor prognosis and metastasis. 15492255 Human
syk tumor Here, we show by in situ hybridization on breast tissue sections that the loss of Syk expression is progressive during tumor development. 15492255 Human
syk cancer Strikingly, Syk is already partially lost in normal epithelial tissue adjacent to the cancer lesion. 15492255 Human
syk ductal carcinoma in situ In vivo, cell proliferation (as measured by the proliferative index Ki67) increased from normal to ductal carcinoma in situ to invasive, whereas Syk in situ staining in the same tissues decreased. 15492255 Human
syk breast cancer In vitro, the presence of Syk was associated with reduced cell proliferation in an epidermal growth factor receptor-overexpressing breast cancer cell line, BT549, whereas changes in apoptosis were undetected. 15492255 Human
syk tumor Because of its progressive and early loss during tumor onset and development, monitoring of Syk loss in breast epithelial cells by noninvasive techniques such as ductal lavage may be a powerful tool for screening purposes. 15492255 Human
syk human breast carcinoma Taken together, the results indicated NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors. 15467753 Human
syk breast cancer Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness. 15455373 Human
syk breast cancer The gene product of spleen tyrosine kinase (SYK) has been implicated in the suppression of breast cancer invasion. 15455373 Human
syk breast cancer We previously reported that SYK expression is lost in a subset of breast cancer; primarily by methylation-mediated gene silencing. 15455373 Human
syk breast cancer In our study, we explored the possibility of using a DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (AZA), to suppress breast cancer cell invasion by restoring SYK expression. 15455373 Human
syk ductal carcinoma in situ In contrast, SYK methylation was frequently identified in ductal carcinoma in situ ( approximately 45%) and invasive ductal carcinoma (47% in node-negative and 40% in node-positive cases), indicating that the hypermethylation of SYK occurs at a stage prio 15455373 Human
syk invasive ductal carcinoma In contrast, SYK methylation was frequently identified in ductal carcinoma in situ ( approximately 45%) and invasive ductal carcinoma (47% in node-negative and 40% in node-positive cases), indicating that the hypermethylation of SYK occurs at a stage prio 15455373 Human
syk advanced breast cancer All these results suggested a potential use of SYK methylation as a valuable biomarker to detect early cancerous lesions and support the use of AZA as a new reagent to the management of advanced breast cancer. 15455373 Human
syk b lymphoma Here we show that 3BP2 is tyrosine phosphorylated following BCR aggregation on B lymphoma cells, and that 3BP2 is a substrate for Syk and Fyn, but not Btk. 15345594 Human
syk mgus Our major findings were: (1) one or more of the three genes was frequently methylated in L/L and MM cell lines and there was good concordance (90-100%) between methylation and loss of gene expression; (2) treatment of L/L cell lines with a demethylating a 15580314 Human
syk monoclonal gammopathy of unknown significance Our major findings were: (1) one or more of the three genes was frequently methylated in L/L and MM cell lines and there was good concordance (90-100%) between methylation and loss of gene expression; (2) treatment of L/L cell lines with a demethylating a 15580314 Human
syk non-hodgkin's lymphomas Our major findings were: (1) one or more of the three genes was frequently methylated in L/L and MM cell lines and there was good concordance (90-100%) between methylation and loss of gene expression; (2) treatment of L/L cell lines with a demethylating a 15580314 Human
syk breast cancer Expression and signaling activity of wnt-5a/discoidin domain receptor-1 and syk plays distinct but decisive roles in breast cancer patient survival. 15701836 Human
syk breast cancer PURPOSE: The loss of Wnt-5a, a G-protein-coupled receptor ligand, or Syk, an intracellular kinase, has in separate studies been associated with poor prognosis of breast cancer patients. 15701836 Human
syk primary breast cancer However, despite a constitutive association between Syk and the Wnt-5a-dependent adhesion receptor DDR1, we found no evidence of a Wnt-5a/DDR1-mediated activation of Syk. 15701836 Human
syk tumor Instead, beta(1) integrins initiate the adhesion-induced activation of Syk. 15701836 Human
syk breast cancer CONCLUSIONS: Despite the difference in regulation of Wnt-5a and Syk protein expression and their lack of signaling interaction, our clinical data indicate that a favorable prognosis in breast cancer requires the expression and signaling activity of both. 15701836 Human
syk mediastinal b-cell lymphomas We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. 15744341 Human
syk lymph-node metastases The results were correlated with the expression of Syk in the lymph node metastases. 15861514 Human
syk invasive breast carcinomas Loss of Syk expression (defined as H< or =1.0) was seen in approximately 1/5 of invasive breast carcinomas, but the majority of metastatic carcinomas (15/21) still strongly expressed Syk, irrespective of Syk expression in primary tumor. 15861514 Human
syk tumors In general, ALK+ tumors overexpress genes encoding signal transduction molecules (SYK , LYN , CDC37) and underexpress transcription factor genes (including HOXC6 and HOX A3 ) compared with the ALK- group. 15948116 Human
syk melanoma The Non-Receptor-Associated Tyrosine Kinase Syk is a Regulator of Metastatic Behavior in Human Melanoma Cells. 15955106 Human
syk melanoma The current study was performed to assess the impact of "spleen tyrosine kinase" (Syk), a non-receptor-associated tyrosine kinase, on growth and metastatic behavior of melanoma cells in vitro and in a severe combined immunodeficient (SCID)-mouse 15955106 Mouse
syk melanoma Syk was expressed in melanocytes but was found to be downregulated in melanoma cells. 15955106 Human
syk melanoma Vector-driven expression of Syk in two different melanoma cell lines did not influence growth speed, but significantly reduced the invasive growth potential of both cell lines in a Matrigel assay in vitro. 15955106 Human
syk tumor In a SCID-mouse/human melanoma xenotransplantation model, Syk expressing Mel-Juso cells exhibited delayed and reduced tumor growth. 15955106 Mouse
syk melanoma In a SCID-mouse/human melanoma xenotransplantation model, Syk expressing Mel-Juso cells exhibited delayed and reduced tumor growth. 15955106 Mouse
syk melanoma The presented data define Syk as a novel regulator of metastatic behavior of melanoma cells. 15955106 Human
syk human breast cancer Growth-related oncogene produced in human breast cancer cells and regulated by Syk protein-tyrosine kinase. 15880583 Human
syk human breast cancer Syk, a nonreceptor type of protein tyrosine kinase widely expressed in hematopoietic cells, is a candidate suppressor gene in human breast cancer. 15880583 Human
syk breast cancer Reduced expression of Syk protein is correlated with poor prognosis, while its overexpression can reduce the malignant phenotype of breast cancer cells. 15880583 Human
syk breast cancer In this study, we utilized low Syk-expressing, highly invasive MDA-MB-231 and high Syk-expressing, less invasive MCF-7 breast cancer cells to investigate the possibility that part of the functional effects of Syk are mediated by cytokines known to play ro 15880583 Human
syk metastasis In this study, we utilized low Syk-expressing, highly invasive MDA-MB-231 and high Syk-expressing, less invasive MCF-7 breast cancer cells to investigate the possibility that part of the functional effects of Syk are mediated by cytokines known to play ro 15880583 Human
syk human breast cancer In summary, our findings provide evidence that human breast cancer cells express and secrete GRO and implicate this cytokine as an essential mediator of the antiinvasive properties of Syk tyrosine kinase. 15880583 Human
the syk gene myelodysplastic syndrome The fusion of the TEL gene to the Syk gene in a patient with myelodysplastic syndrome (MDS) with t(9;12)(q22;p12) is reported. 11159536 Human
the syk gene human breast cancer Hypermethylation leads to silencing of the SYK gene in human breast cancer. 11454707 Human
the syk gene breast cancer In this study, we examined the 5' CpG island methylation status of the SYK gene in breast cancer cell lines and primary breast cancer tissues. 11454707 Human
the syk gene primary breast cancer In this study, we examined the 5' CpG island methylation status of the SYK gene in breast cancer cell lines and primary breast cancer tissues. 11454707 Human
the syk gene leukemia Examination of the genomic structure of the Syk gene by inter-exonic PCR and genomic cloning demonstrated that the deletions and insertions in the abnormal mRNA species of pro-B leukemia cells are caused by aberrant splicing resulting in either mis-splici 11494125 Human
the syk gene childhood all Our findings link for the first time specific molecular defects involving the Syk gene to an immunophenotypically distinct category of childhood ALL. 11494125 Human
the syk gene human breast cancer Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. 12445683 Human
the syk gene myelodysplastic syndrome We previously reported the fusion of the TEL gene to the Syk gene in myelodysplastic syndrome with t(9;12)(q22;p12). 14749700 Human
the syk gene breast cancer METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
the syk gene fibroadenoma METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
the syk gene tumor METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
the syk gene human breast carcinoma CONCLUSION: Hypermethylation leads to lose of the syk gene expression in human breast carcinoma. 15059510 Human
the syk gene tumor [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk gene metastasis [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk gene human breast cancer [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk gene breast cancer METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
the syk gene fibroadenoma METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
the syk gene tumor METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
the syk gene breast cancer CONCLUSION: The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer. 15062056 Human
the syk gene metastasis CONCLUSION: The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer. 15062056 Human
the syk gene human gastric carcinoma CONCLUSION: Hypermethylation leads to silencing of the Syk gene in human gastric carcinoma. 15188513 Human
the syk mrna leukemia Sequencing of the reverse transcriptase-polymerase chain reaction (RT-PCR) products of the Syk mRNA in these pro-B leukemia cells revealed profoundly aberrant coding sequences with deletions or insertions. 11494125 Human
the syk mrna tumor [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk mrna metastasis [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk mrna human breast cancer [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
the syk mrna breast cancer Furthermore, only one breast cancer tissue in 18 patients with lymph node metastasis had the Syk mRNA expression, the rate and level of Syk mRNA expression in the patients with lymph node metastasis were lower than those without lymph node metastasis (chi 15062056 Human
the syk mrna lymph-node metastasis Furthermore, only one breast cancer tissue in 18 patients with lymph node metastasis had the Syk mRNA expression, the rate and level of Syk mRNA expression in the patients with lymph node metastasis were lower than those without lymph node metastasis (chi 15062056 Human
spleen tyrosine kinase metastasis AIM: To investigate the relationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metastasis of gastric carcinoma. 15188513 Human
spleen tyrosine kinase gastric carcinoma AIM: To investigate the relationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metastasis of gastric carcinoma. 15188513 Human
spleen tyrosine kinase metastasis [Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma] OBJECTIVE: To investigate the relationship between methylation of syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metast 15059510 Human
spleen tyrosine kinase breast carcinoma [Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma] OBJECTIVE: To investigate the relationship between methylation of syk (spleen tyrosine kinase) gene in promoter region and oncogenesis, metast 15059510 Human
spleen tyrosine kinase breast cancer The gene product of spleen tyrosine kinase (SYK) has been implicated in the suppression of breast cancer invasion. 15455373 Human
syk cutaneous t cell lymphoma Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk. 9264390 Human
syk thymoma Determination of the expression levels of Fyn, ZAP-70 and Syk in thymocytes form the Lck(-/-) thymoma revealed high levels of ZAP-70 overexpression and recovery of a specific subset of phosphoproteins as compared to Lck(-/-) thymocytes. 10781838 Human
syk mds The fusion of the TEL gene to the Syk gene in a patient with myelodysplastic syndrome (MDS) with t(9;12)(q22;p12) is reported. 11159536 Human
syk tumor Alterations in the expression of several genes detected during tumor progression were consistent with their functional activities involving growth (p21, p27, and cyclin D1), resistance and apoptosis (glutathione-S-transferase, cIAP-1, PEA-15, and Fas liga 11406555 Human
syk childhood all Our findings link for the first time specific molecular defects involving the Syk gene to an immunophenotypically distinct category of childhood ALL. 11494125 Human
syk osteosarcoma Prostaglandin E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells. 12009018 Human
syk osteosarcoma Finally, we provide evidence that this Syk/hSlo interaction does not affect the electrical features of BK channels in osteosarcoma cells. 12009018 Human
syk cll Ligation of the B-cell receptor (BCR) complex on CLL cells that expressed ZAP-70 induced significantly greater tyrosine phosphorylation of cytosolic proteins, including p72(Syk), than did similar stimulation of CLL cells that did not express ZAP-70. 12393534 Human
syk all MSP screening of leukemia cells from six T-lineage acute lymphoblastic leukemia (ALL) patients demonstrated methylation of the Syk promoter CpG island in one T-lineage ALL patient. 12717427 Human
syk breast tumors We also show that the aberrant expression of Syk(S) occurs frequently in primary breast tumors but never in matched normal mammary tissues, suggesting a contribution of Syk(S) to mammary tumor progression. 12907655 Human
syk mammary tumor We also show that the aberrant expression of Syk(S) occurs frequently in primary breast tumors but never in matched normal mammary tissues, suggesting a contribution of Syk(S) to mammary tumor progression. 12907655 Human
syk breast cancer Expression of Syk(L) suppressed breast cancer cell invasiveness. 12907655 Human
syk granulosa cell tumours (gcts) Promoter hypermethylation of MGMT, CDH1, RAR-beta and SYK tumour suppressor genes in granulosa cell tumours (GCTs) of ovarian origin. 14970867 Human
syk breast cancer METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
syk fibroadenoma METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
syk tumor METHODS: Using RT-PCR technique, specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the syk gene. 15059510 Human
syk breast carcinoma RESULTS: The expression of syk gene were detected in normal breast tissues and fibroadenoma samples, 9 out of 40 breast carcinoma samples were found the expression of syk mRNA, syk expression in breast carcinoma was lower than that in adjacent normal tiss 15059510 Human
syk fibroadenoma RESULTS: The expression of syk gene were detected in normal breast tissues and fibroadenoma samples, 9 out of 40 breast carcinoma samples were found the expression of syk mRNA, syk expression in breast carcinoma was lower than that in adjacent normal tiss 15059510 Human
syk human breast carcinoma CONCLUSION: Hypermethylation leads to lose of the syk gene expression in human breast carcinoma. 15059510 Human
syk breast carcinoma Methylation of syk promoter may be correlated to oncogenesis, metastasis of breast carcinoma. 15059510 Human
syk metastasis Methylation of syk promoter may be correlated to oncogenesis, metastasis of breast carcinoma. 15059510 Human
syk human breast cancer [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
syk metastasis [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
syk tumor [Expression of tyrosine kinase Syk in breast cancer and their clinical significance] OBJECTIVE: To evaluate the effects of the Syk mRNA expression in human breast cancer on tumor growth and metastasis, and to study the correlation of expression of the Syk 15062056 Human
syk breast cancer METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
syk fibroadenoma METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
syk tumor METHODS: Specimens from 40 breast cancer patients (tumor tissues, adjacent normal tissues), 15 fibroadenoma were detected for their expression of the Syk gene and level of Syk mRNA by semi-RT-PCR technique. 15062056 Human
syk breast cancer Unlike normal breast tissue, 31 out of 40 breast cancer tissue did not show any detectable Syk mRNA expression, there were significant difference in two groups (chi(2) = 47.4, P < 0.05). 15062056 Human
syk primary breast cancer The level of Syk mRNA in the primary breast cancer tissues were significantly lower than that in the adjacent non-cancerous breast tissues (t = 3.41, P < 0.05). 15062056 Human
syk breast cancer Furthermore, only one breast cancer tissue in 18 patients with lymph node metastasis had the Syk mRNA expression, the rate and level of Syk mRNA expression in the patients with lymph node metastasis were lower than those without lymph node metastasis (chi 15062056 Human
syk breast cancer CONCLUSION: The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer. 15062056 Human
syk metastasis CONCLUSION: The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer. 15062056 Human
syk gastric carcinoma No methylation of Syk promoter was found in adjacent normal tissues. hypermethylation of Syk gene in promoter was detected 21 cases in 61 gastric carcinoma patients. 15188513 Human
syk human gastric carcinoma CONCLUSION: Hypermethylation leads to silencing of the Syk gene in human gastric carcinoma. 15188513 Human
syk gastric carcinoma Methylation of Syk promoter is correlated to oncogenesis and metastasis of gastric carcinoma. 15188513 Human
syk metastasis Methylation of Syk promoter is correlated to oncogenesis and metastasis of gastric carcinoma. 15188513 Human
syk human gastric cancer Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human gastric cancer. 15188513 Human
syk tumor Syk is considered to be a potential tumor suppressor and anti-metastasis gene in human gastric cancer. 15188513 Human
syk cll Following IgM ligation, ZAP-70+ CLL cells had significantly higher levels of phosphorylated p72(Syk), BLNK, and phospholipase-Cgamma (PLCgamma) and had greater[Ca2+]i flux than did ZAP-70-negative CLL cases, including unusual ZAP-70-negative cases with un 15514014 Human
syk cll IgM ligation of ZAP-70-negative CLL B cells infected with an adenovirus vector encoding ZAP-70 induced significantly greater levels of phosphorylated p72(Syk), BLNK, and PLCgamma and had greater[Ca2+]i flux than did similarly stimulated, noninfected CLL c 15514014 Human
syk t-all PATIENTS AND METHODS: Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1, ASPP-1, CDH1, CDH13, DAPK, DIABLO, DKK-3, LATS-1, LATS-2, NES-1, p14, p15, p16, p57, p73, PARK-2, PTEN, sFRP1/2/4/5, SH 16192589 Human
syk tumor The Syk tyrosine kinase: A new negative regulator in tumor growth and progression. 16442709 Human
syk breast cancer A significant drop in its expression was first observed during breast cancer progression, but an anomalous Syk expression has now also been evidenced in many other tumor types. 16442709 Human
syk other tumor A significant drop in its expression was first observed during breast cancer progression, but an anomalous Syk expression has now also been evidenced in many other tumor types. 16442709 Human
syk metastasis Mechanistic studies using Syk re-expression demonstrated its suppressive function in tumorigenesis and metastasis formation, which is surprising for a tyrosine kinase. 16442709 Human
syk metastasis An increasing number of clinical studies reveal a correlation between reduced Syk expression and an increased risk for metastasis formation, and assign Syk as a potential new prognostic marker in different tumor types. 16442709 Human
syk tumor An increasing number of clinical studies reveal a correlation between reduced Syk expression and an increased risk for metastasis formation, and assign Syk as a potential new prognostic marker in different tumor types. 16442709 Human
syk transitional cell carcinomas Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. 16964403 Human
syk urinary bladder carcinomas Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. 16964403 Human
syk cancers To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG dinucleotides at 5' promoter regions, we analysed the methylation status of a broad panel of different genes in transiti 16964403 Human
syk transitional cell carcinomas (tcc) To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG dinucleotides at 5' promoter regions, we analysed the methylation status of a broad panel of different genes in transiti 16964403 Human
syk squamous cell carcinomas Squamous cell carcinomas revealed a peak incidence of hypermethylation of the 14-3-3 sigma gene (80%), and conversely, the lowest methylation frequency of the SYK gene (13.3%). 16964403 Human
syk small cell carcinomas Undifferentiated small cell carcinomas disclosed a promoter methylation of the 14-3-3 sigma, SYK and CAGE-1 genes in only a quarter each for the cases. 16964403 Human
syk bladder carcinomas Although a correlation between the methylation status and gene activity in squamous cell and undifferentiated small cell carcinomas was not observed, the underexpression of the SYK protein products in both cancer types and additionally of the 14-3-3 sigma 16964403 Human
syk cancer Although a correlation between the methylation status and gene activity in squamous cell and undifferentiated small cell carcinomas was not observed, the underexpression of the SYK protein products in both cancer types and additionally of the 14-3-3 sigma 16964403 Human
syk small cell carcinomas Although a correlation between the methylation status and gene activity in squamous cell and undifferentiated small cell carcinomas was not observed, the underexpression of the SYK protein products in both cancer types and additionally of the 14-3-3 sigma 16964403 Human
syk cancer In conclusion, the different patterns of aberrant methylation of the 14-3-3 sigma, SYK and CAGE-1 genes in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation, resulting in the phenotypical conve 16964403 Human
syk carcinomas In conclusion, the different patterns of aberrant methylation of the 14-3-3 sigma, SYK and CAGE-1 genes in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation, resulting in the phenotypical conve 16964403 Human
syk tumor In conclusion, the different patterns of aberrant methylation of the 14-3-3 sigma, SYK and CAGE-1 genes in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation, resulting in the phenotypical conve 16964403 Human
syk casitas b-lineage lymphoma (cbl) Here we further report that stimulation with GM-CSF causes phosphorylation of Syk protein kinase, but neither Casitas B-lineage lymphoma (Cbl) nor Cbl-b in CD34(+) hemopoietic progenitors can be blocked by anti-CD116 mAb. 11591765 Human
syk rat basophilic leukemia (rbl) We illustrate the value of the model in analyzing experimental data by using it to show that the intrinsic rate of dephosphorylation of the FcepsilonRI gamma immunoreceptor tyrosine-based activation motif (ITAM) in rat basophilic leukemia (RBL) cells is m 12217386 Rat
syk b cell lymphoma RESULTS: A mutant form of Syk carrying a combination of a K395A substitution in the kinase domain and substitutions of three phenylalanines (3F) for the three C-terminal tyrosines was expressed in a murine B cell lymphoma cell line, BCL1.3B3 to interfere 12470302 Mouse
syk lymph node metastasis In 18 cases with lymph node metastasis, 14 were found with syk promoter methylation. 15059510 Human
syk lymph node metastasis Furthermore, only one breast cancer tissue in 18 patients with lymph node metastasis had the Syk mRNA expression, the rate and level of Syk mRNA expression in the patients with lymph node metastasis were lower than those without lymph node metastasis (chi 15062056 Human
syk lymph node metastasis In 31 patients with lymph node metastasis, 17 were found with Syk promoter methylation. 15188513 Human
syk b cell lymphomas We report that these signaling molecules are frequently present, and in particular that Syk, BLNK and PLC-gamma2 (absent from Reed-Sternberg cells) are present in the majority of mediastinal B cell lymphomas. 15744341 Human
syk lymph node metastases The results were correlated with the expression of Syk in the lymph node metastases. 15861514 Human
syk gastric cancer Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer. 15993535 Human
syk gastric cancer Spleen tyrosine kinase (Syk) expression was immunohistochemically examined in 250 gastric cancer patients. 15993535 Human
syk tumors Syk expression was significantly associated with T1 tumors, lymphatic invasion, venous invasion and lymph node metastasis (P<0.0001). 15993535 Human
syk early gastric cancer Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer. 15993535 Human
syk gastric cancer Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer. 15993535 Human
syk tumor Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer. 15993535 Human
syk acute lymphoblastic leukemia (all) We evaluated the expression of 2 members of the Syk family, ZAP-70 and Syk, in acute lymphoblastic leukemia (ALL) samples, using data derived from a series of 33 T-ALL and 95 B-lineage adult ALL patients analyzed by oligonucleotide arrays. 16160012 Human
syk adult all We evaluated the expression of 2 members of the Syk family, ZAP-70 and Syk, in acute lymphoblastic leukemia (ALL) samples, using data derived from a series of 33 T-ALL and 95 B-lineage adult ALL patients analyzed by oligonucleotide arrays. 16160012 Human
syk t-all We evaluated the expression of 2 members of the Syk family, ZAP-70 and Syk, in acute lymphoblastic leukemia (ALL) samples, using data derived from a series of 33 T-ALL and 95 B-lineage adult ALL patients analyzed by oligonucleotide arrays. 16160012 Human
syk other cancers Among candidate hypermethylated genes in cancer-derived lines, there were eight (CD44, CDKN1A, ESR1, PLAU, RARB, SFN, TNFRSF6, and TSPY) previously observed in prostate cancer and 13 previously known methylation targets in other cancers (ARHI, bcl-2, BRCA 16207477 Human
syk prostate cancer Among candidate hypermethylated genes in cancer-derived lines, there were eight (CD44, CDKN1A, ESR1, PLAU, RARB, SFN, TNFRSF6, and TSPY) previously observed in prostate cancer and 13 previously known methylation targets in other cancers (ARHI, bcl-2, BRCA 16207477 Human
syk chronic lymphocytic leukemia Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia. 16266901 Human
syk cll We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard. 16266901 Human
syk cll DESIGN AND METHODS: The relative amounts of ZAP-70 and Syk were determined in purified B cells from 92 CLL patients using a novel reverse transcriptase/polymerase chain reaction (RT-PCR) procedure that co-amplifies both transcripts with equal efficiency. 16266901 Human
syk rb However, their differential effects on cell spreading, bacteria-induced RB, TNF-induced degranulation, TNF-induced protein tyrosine phosphorylation, and TNF-induced Syk activation suggested that each may act on different elements of neutrophil signaling p 16275893 Human
syk breast cancer Loss of SYK expression in breast tumors as a result of DNA hypermethylation promotes tumor cell proliferation and invasion and predicts shorter survival of breast cancer patients. 16288017 Human
syk breast tumors Loss of SYK expression in breast tumors as a result of DNA hypermethylation promotes tumor cell proliferation and invasion and predicts shorter survival of breast cancer patients. 16288017 Human
syk tumor Loss of SYK expression in breast tumors as a result of DNA hypermethylation promotes tumor cell proliferation and invasion and predicts shorter survival of breast cancer patients. 16288017 Human
syk tumor We previously reported that, in addition to its well-known cytoplasmic localization, the full-length Syk is also present in the nucleus and that Syk nuclear translocation is a rate-limiting step to determine Syk tumor suppressor function. 16288017 Human
syk b lymphoma Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav. 16289966 Human
syk chl We assessed the expression and methylation status of CD19, CD20, CD79B, SYK, PU.1, BOB.1/OBF.1, BCMA, and LCK, all of which are typically down-regulated in cHL. 16304050 Human
syk chl Ectopic expression of both Oct2 and PU.1 in a cHL cell line potentiated endogenous PU.1 and SYK expression after 5-aza-dC treatment. 16304050 Human
syk breast cancer We showed previously that the spleen tyrosine kinase Syk is expressed by mammary epithelial cells and that it suppresses malignant growth of breast cancer cells. 16322234 Human
syk metaplasia The Syk inhibitor R406 (30 mg/kg, administered orally, twice daily) prevented the development of AHR, increases in eosinophils and lymphocytes and IL-13 levels in bronchoalveolar lavage (BAL) fluid, and goblet cell metaplasia when administered after sensi 16339999 Human
syk unspecified peripheral t-cell lymphoma Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. 16341044 Human
syk mantle cell lymphoma Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. 16409295 Human
syk breast cancer In breast cancer, Syk has been suggested to be a tumor suppressor. 16431925 Human
syk tumor However, the roles of Syk in tumor migration are still largely unknown. 16431925 Human
syk breast cancer Hypoxia Regulates Cross-talk between Syk and Lck Leading to Breast Cancer Progression and Angiogenesis. 16474166 Human
syk breast carcinoma The enhanced expression of Syk in normal breast tissue but not in malignant breast carcinoma has prompted us to investigate its potential role in mammary carcinogenesis. 16474166 Human
syk breast tumor The mice xenograft study showed the cross-talk between Syk and Lck regulated H/R-induced breast tumor progression and further correlated with the expressions of MelCAM, uPA, MMP-9, and VEGF. 16474166 Mouse
syk breast cancer To our knowledge, this is first report that the cross-talk between Syk and Lck regulates H/R-induced breast cancer progression and further suggests that Syk may act as potential therapeutic target for the treatment of breast cancer. 16474166 Human
syk b lymphoma The BCR signals in lymphoma appear to be mediated by Syk, as it is constitutively active in a variety of B lymphoma cells. 16670274 Human
syk b lymphomas Blocking Syk activity by selective inhibitors suppresses growth of several murine and human B lymphomas. 16670274 Human
spleen tyrosine kinase gastric cancer Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer. 15993535 Human
spleen tyrosine kinase gastric cancer Spleen tyrosine kinase (Syk) expression was immunohistochemically examined in 250 gastric cancer patients. 15993535 Human
spleen tyrosine kinase breast tumor Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression. 16288017 Human
spleen tyrosine kinase breast cancer We showed previously that the spleen tyrosine kinase Syk is expressed by mammary epithelial cells and that it suppresses malignant growth of breast cancer cells. 16322234 Human
syk lymph node metastasis Syk expression was significantly associated with T1 tumors, lymphatic invasion, venous invasion and lymph node metastasis (P<0.0001). 15993535 Human
syk lymph node metastasis Loss of Syk expression was closely related to the malignant property of gastric cancer in the context of tumor depth and lymph node metastasis, especially in early gastric cancer. 15993535 Human
syk lymphoma DT-40 lymphoma B cells, rendered BTK-deficient through targeted disruption of the btk gene by homologous recombination knockout, did not undergo radiation-induced apoptosis, but cells with disrupted lyn or syk genes did. 8688094 Human
syk oncogene The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. 9103201 Human
syk oncogene Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. 9186005 Human
syk lymphoma Our findings in the lymphoma model show that an initial Ag encounter renders receptors unresponsive to subsequent Ag challenge, as measured by their inability to mobilize Ca2+ and to mediate phosphorylation of receptor-proximal kinases, including Lyn, Blk 9200459 Human
syk lymphoma Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields. 9461594 Human
syk lymphoma A deficiency in Syk enhances ceramide-induced apoptosis in DT40 lymphoma B cells. 9613615 Human
syk lymphoma Lymphoma B-cells rendered deficient for LYN, SYK, or both by targeted gene disruption showed increased c-jun expression levels after radiation exposure, but the magnitude of the stimulation was lower than in wild-type cells. 9651374 Human
syk oncogenes The mapped genes include three oncogenes (Fyn, Mas1, and Vav1), a tyrosine kinase gene (Syk), a tumor-associated antigen gene (Cd24), a growth factor receptor gene (Igf2r), the gene for an activator of c-fos/c-jun transcription factors (Apex), a transcrip 9730607 Human
syk rat basophilic leukemia The various mutants were expressed in a Syk-negative variant of the RBL-2H3 (rat basophilic leukemia 2H3) mast cell line. 9780214 Rat
syk oncogene The proto-oncogene product Cbl has emerged as a potential negative regulator of the Syk tyrosine kinase; however, the nature of physical interactions between Cbl and Syk that are critical for this negative regulation remains unclear. 9857068 Human
syk lymphoma Here we demonstrate that calphostin C induces dose-dependent apoptosis in DT40 chicken lymphoma B-cells, and targeted disruption of lyn, syk, btk, PLCgamma2, or IP3R genes does not prevent or attenuate its cytotoxicity. 9865907 Chicken
syk carcinoma of breast It was displayed by immunohistochemical staining with anti-Sykantibody that in normal breast tissue Syk was high expression; while in infilfrative dustal carcinoma of breast tissue the expression of syk was negative. 15169665 Human
syk breast cancer The Syk is high expression in normal breast tissue, but is deficient in breast cancer tissue. 15169665 Human
syk leukemia Sequencing of the reverse transcriptase-polymerase chain reaction (RT-PCR) products of the Syk mRNA in these pro-B leukemia cells revealed profoundly aberrant coding sequences with deletions or insertions. 11494125 Human
syk leukemia In contrast to pro-B leukemia cells, pre-pre-B leukemia cells from children with CD19(+)CD10(+) common B-lineage ALL and EBV-transformed B-cell lines from healthy volunteers expressed wild-type Syk coding sequences. 11494125 Human
syk leukemia Examination of the genomic structure of the Syk gene by inter-exonic PCR and genomic cloning demonstrated that the deletions and insertions in the abnormal mRNA species of pro-B leukemia cells are caused by aberrant splicing resulting in either mis-splici 11494125 Human
syk osteosarcoma Prostaglandin E2 induces interaction between hSlo potassium channel and Syk tyrosine kinase in osteosarcoma cells. 12009018 Human
syk breast cancer These data further demonstrate a functional molecular link between Syk-regulated PI 3'-kinase activity and NF kappa B-mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells. 12477728 Human
syk lymphoma SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells. 12533043 Human
syk b lymphoma Here, we report that the calcium ionophore ionomycin induces a massive Ca2+-dependent apoptosis in wildtype DT-40 chicken B lymphoma cells, as well as in BTK-deficient, PLCgamma2-deficient and IP3 receptor-deficient DT-40 cells, but not in LYN- or SYK-def 12533043 Chicken
syk lymphoma Taken together, our data suggests that both LYN and SYK, but not BTK, FYN or LCK, are crucial mediators of BCR-independent Ca2+-induced apoptosis in DT-40 lymphoma B cells. 12533043 Human
syk leukemia Bisulfite sequencing and methylation-specific PCR (MSP) of this region demonstrated that the Syk promoter CpG island was largely unmethylated in B-lineage leukemia cell lines, control peripheral blood cells, human thymocytes and CD3(+) T lymphocytes. 12717427 Human
syk leukemia MSP screening of leukemia cells from six T-lineage acute lymphoblastic leukemia (ALL) patients demonstrated methylation of the Syk promoter CpG island in one T-lineage ALL patient. 12717427 Human
syk leukemia Promoter methylation was correlated with reduced to absent expression of Syk mRNA and SYK protein in the T-lineage leukemia cell lines. 12717427 Human
syk leukemia Treatment of the leukemia lines Ha and Molt 3, with the methylation inhibitor, 5-aza-2'-deoxycytidine (5-aza-CdR) resulted in increased Syk mRNA expression. 12717427 Human
syk leukemia The presence of a methylated promoter sequence in these T-lineage leukemia cell lines and in one T-lineage patient suggests a potential role for SYK as a tumor suppressor in T-ALL. 12717427 Human
syk tumor In this study, we established a leukemic cell line, termed SYK-11L(+), from tumor cells (S-YU) in an in vivo cell proliferation model of ATL using severe combined immunodeficiency (SCID) mice. 15132768 Mouse
syk cancerous lesions All these results suggested a potential use of SYK methylation as a valuable biomarker to detect early cancerous lesions and support the use of AZA as a new reagent to the management of advanced breast cancer. 15455373 Human
syk leukemias Our major findings were: (1) one or more of the three genes was frequently methylated in L/L and MM cell lines and there was good concordance (90-100%) between methylation and loss of gene expression; (2) treatment of L/L cell lines with a demethylating a 15580314 Human
syk primary tumors Analysis of breast cancer-specific survival revealed that the presence of Wnt-5a and Syk in primary tumors has good predictive value for a favorable outcome. 15701836 Human
syk carcinogenesis Syk tyrosine kinase expression during multistep mammary carcinogenesis. 15861514 Human
syk carcinogenesis AIM: To analyze the expression of Syk tyrosine kinase, recently implicated as a tumor suppressor in mammary carcinogenesis, during the multi step development of human breast carcinoma. 15861514 Human
syk primary tumor Loss of Syk expression (defined as H< or =1.0) was seen in approximately 1/5 of invasive breast carcinomas, but the majority of metastatic carcinomas (15/21) still strongly expressed Syk, irrespective of Syk expression in primary tumor. 15861514 Human
syk oncogene Growth-related oncogene produced in human breast cancer cells and regulated by Syk protein-tyrosine kinase. 15880583 Human
syk metastatic tumor After intravenous as well as subcutaneous injection of tumor cells, Syk-transfected cells formed significantly fewer metastatic tumor lesions than control cells. 15955106 Human
syk tumor After intravenous as well as subcutaneous injection of tumor cells, Syk-transfected cells formed significantly fewer metastatic tumor lesions than control cells. 15955106 Human
syk cancer Among candidate hypermethylated genes in cancer-derived lines, there were eight (CD44, CDKN1A, ESR1, PLAU, RARB, SFN, TNFRSF6, and TSPY) previously observed in prostate cancer and 13 previously known methylation targets in other cancers (ARHI, bcl-2, BRCA 16207477 Human
syk tumorigenesis Thus, breast tumorigenesis and progression resulting from the loss of SYK are underscored by the derepression of Sp1-mediated oncogene transcription. 16288017 Human
syk lymphomas A combination of genomic and expression profiling suggested Syk inhibition as a new therapeutic strategy to be explored in lymphomas. 16409295 Human
syk carcinogenesis Limited data suggest that Syk plays alternate roles in carcinogenesis under different circumstances. 16431925 Human
syk tumorigenesis Mechanistic studies using Syk re-expression demonstrated its suppressive function in tumorigenesis and metastasis formation, which is surprising for a tyrosine kinase. 16442709 Human
syk carcinogenesis The enhanced expression of Syk in normal breast tissue but not in malignant breast carcinoma has prompted us to investigate its potential role in mammary carcinogenesis. 16474166 Human
syk lymphoma The BCR signals in lymphoma appear to be mediated by Syk, as it is constitutively active in a variety of B lymphoma cells. 16670274 Human
syk tumor BCR-mediated signaling via phosphorylation of Btk, Syk, Erk1/2, and p38 occurred more rapidly in tumor B cells from FL samples than in infiltrating nontumor B cells, achieved greater levels of per-cell signaling, and sustained this level of signaling for 16835385 Human
syk follicular lymphoma Syk-dependent mTOR activation in follicular lymphoma cells. 16912221 Human
syk chronic lymphocytic leukemia Moreover, we demonstrated that Syk plays a central role in mTOR activation because we found that both expression and activity are elevated compared to normal or chronic lymphocytic leukemia B cells. 16912221 Human
syk burkitt lymphoma Finally, Syk inhibition by piceatannol or by siRNA plasmids resulted in a potent inhibition of mTOR activity in FL cells, as well as in mantle cell lymphoma, Burkitt lymphoma, and diffuse large B-cell lymphoma. 16912221 Human
syk mantle cell lymphoma Finally, Syk inhibition by piceatannol or by siRNA plasmids resulted in a potent inhibition of mTOR activity in FL cells, as well as in mantle cell lymphoma, Burkitt lymphoma, and diffuse large B-cell lymphoma. 16912221 Human
syk diffuse large b-cell lymphoma Finally, Syk inhibition by piceatannol or by siRNA plasmids resulted in a potent inhibition of mTOR activity in FL cells, as well as in mantle cell lymphoma, Burkitt lymphoma, and diffuse large B-cell lymphoma. 16912221 Human
syk carcinogenesis To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG dinucleotides at 5' promoter regions, we analysed the methylation status of a broad panel of different genes in transiti 16964403 Human
syk tcc The higher frequency of promoter methylation of the 14-3-3 sigma (57.1%) and SYK (64.3%) genes in high-grade, high-stage TCC in association with a reduced or even lacking immunohistochemical protein expression than in low-grade, low-stage TCC (28.6% and 4 16964403 Human
syk tcc The importance of DNA hypermethylation in the conversion of TCC from a low to a high malignant potential was strongly supported by the finding that, unlike superficial low-grade TCC, advanced muscle invasive TCC showed a concurrent promoter methylation of 16964403 Human
syk tcc In conclusion, the different patterns of aberrant methylation of the 14-3-3 sigma, SYK and CAGE-1 genes in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation, resulting in the phenotypical conve 16964403 Human
syk acute myeloid leukemia Cytotoxic activity of gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia correlates with the expression of protein kinase Syk. 17051243 Human
syk acute myeloid leukemia (aml) Acute myeloid leukemia (AML) cells express the cell surface antigen CD33 that, upon ligation with a monoclonal antibody (mAb), is a downregulator of cell growth in a Syk-dependent manner. 17051243 Human
syk aml Therefore, we investigated whether the response of AML cells to GO treatment also depends on Syk expression. 17051243 Human
syk aml Forty primary AML samples (25 Syk-positive and 15 Syk-negative) were tested for their response to the anti-proliferative effects of GO and unmodified anti-CD33 mAb. 17051243 Human
syk leukemia A correlation between Syk expression and the response of leukemia cells to GO and anti-CD33 mAb was found. 17051243 Human
syk aml 'Blocking' of Syk by small interfering RNA resulted in unresponsiveness of AML cells to both GO and anti-CD33 mAb-mediated cytotoxicity. 17051243 Human
syk leukemia Syk upregulation by the de-methylating agent 5-azacytidine (5-aza) induced re-expression of Syk in some cases, resulting in enhanced GO and anti-CD33-mediated inhibition of leukemia cell growth. 17051243 Human
syk aml Thus, the cytotoxicity of both GO and anti-CD33 in primary AML samples was associated with Syk expression. 17051243 Human
syk acute myeloid leukemia Fusion genes involving ABL, ARG, PDGFRs, JAK2, SYK, TRKC, and FGFRs, and gain-of-function mutations of FLT3, KIT and JAK2 have been detected at various rates in myeloproliferative disease and acute myeloid leukemia. 17076649 Human
syk hcc PURPOSE: The aim of present study was to investigate the methylation and expression status of spleen tyrosine kinase (SYK) in human hepatocellular carcinoma (HCC) and to evaluate this information for its ability to predict disease prognosis. 17121887 Human
syk human hepatocellular carcinoma PURPOSE: The aim of present study was to investigate the methylation and expression status of spleen tyrosine kinase (SYK) in human hepatocellular carcinoma (HCC) and to evaluate this information for its ability to predict disease prognosis. 17121887 Human
syk hcc EXPERIMENTAL DESIGN: We analyzed the methylation status of SYK, E-cadherin, and TIMP-3 in 124 cases of HCC and assessed the correlation of such methylations with clinicopathologic variables and prognosis after tumor resection. 17121887 Human
syk tumor EXPERIMENTAL DESIGN: We analyzed the methylation status of SYK, E-cadherin, and TIMP-3 in 124 cases of HCC and assessed the correlation of such methylations with clinicopathologic variables and prognosis after tumor resection. 17121887 Human
syk hcc RESULTS: We found that SYK, E-cadherin, and TIMP-3 genes were methylated in 27%, 27%, and 42% of HCC neoplastic tissues, respectively. 17121887 Human
syk hcc CONCLUSIONS: Our results indicate that SYK methylation and loss of Syk expression in HCC neoplastic tissues are independent biomarkers of poor patient outcome and that determination of SYK methylation or Syk expression status may offer guidance for select 17121887 Human
syk leukemia We show that deregulated Syk activity allows growth factor-independent proliferation and transforms bone marrow-derived pre-B cells that are then able to induce leukemia in mice. 17130299 Mouse
syk oncogenes Because R406 treatment also prevents the proliferation of c-Myc-transformed pre-B cells, our data indicate that endogenous Syk kinase activity may be required for the survival of pre-B cells transformed by other oncogenes. 17130299 Human
syk leukemia Collectively, our data suggest that Syk is a protooncogene involved in the transformation of lymphocytes, thus making Syk a potential target for the treatment of leukemia. 17130299 Human
syk gastric cancer [Effect of spleen tyrosine kinase expression re-activation by inhibition of DNA methylation on oncogenesis growth of gastric cancer] OBJECTIVE: To explore the effects of 5-Aza-2'-deoxycytidine on spleen tyrosine kinase (Syk) expression by inhibition 17143801 Human
syk human gastric cancer METHODS: Syk mRNA of SGC7901, MGC803, MKN28 and MKN45 cell lines were analyzed by RT-PCR, and Syk methylation were detected by MSP. 5-aza-CDR was used to incubate with human gastric cancer cell line SGC7901, Methylation of Syk promoter region was detected 17143801 Human
syk gastric cancer RESULTS: No Syk mRNA were found in SGC7901 and MKN45 gastric cancer cell lines, but methylation of Syk were detected in those cell lines. 17143801 Human
syk human gastric cancer Syk gene re-expression suppress the malignant oncogenesis and growth of human gastric cancer. 17143801 Human
syk melanoma Reexpression of either of two of the silenced genes, HOXB13 and SYK, resulted in reduced colony formation in vitro and diminished tumor formation in vivo, indicating that these genes function as tumor suppressors in melanoma. 17145863 Human
syk b lymphoma Spleen tyrosine kinase (syk), a novel target of curcumin, is required for B lymphoma growth. 17182546 Human
syk b lymphoma We identified a novel target for curcumin in B lymphoma viz spleen tyrosine kinase (Syk). 17182546 Human
syk b lymphoma Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation. 17182546 Human
syk primary tumors Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation. 17182546 Human
syk b lymphoma Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells. 17182546 Human
syk lymphoma These observations suggest a novel growth promoting role for Syk in lymphoma cells. 17182546 Human
spleen tyrosine kinase human hepatocellular carcinoma Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. 17121887 Human
spleen tyrosine kinase hcc PURPOSE: The aim of present study was to investigate the methylation and expression status of spleen tyrosine kinase (SYK) in human hepatocellular carcinoma (HCC) and to evaluate this information for its ability to predict disease prognosis. 17121887 Human
spleen tyrosine kinase human hepatocellular carcinoma PURPOSE: The aim of present study was to investigate the methylation and expression status of spleen tyrosine kinase (SYK) in human hepatocellular carcinoma (HCC) and to evaluate this information for its ability to predict disease prognosis. 17121887 Human
spleen tyrosine kinase gastric cancer [Effect of spleen tyrosine kinase expression re-activation by inhibition of DNA methylation on oncogenesis growth of gastric cancer] OBJECTIVE: To explore the effects of 5-Aza-2'-deoxycytidine on spleen tyrosine kinase (Syk) expression by inhibition 17143801 Human
spleen tyrosine kinase b lymphoma Spleen tyrosine kinase (syk), a novel target of curcumin, is required for B lymphoma growth. 17182546 Human
spleen tyrosine kinase b lymphoma We identified a novel target for curcumin in B lymphoma viz spleen tyrosine kinase (Syk). 17182546 Human
syk tumors In tumors from breast cancer patients, the protein expression of Wnt-5a and Syk were differently regulated at the translational and transcriptional level, respectively. 15701836 Human
syk breast cancer In tumors from breast cancer patients, the protein expression of Wnt-5a and Syk were differently regulated at the translational and transcriptional level, respectively. 15701836 Human
syk human breast carcinoma AIM: To analyze the expression of Syk tyrosine kinase, recently implicated as a tumor suppressor in mammary carcinogenesis, during the multi step development of human breast carcinoma. 15861514 Human
syk invasive carcinomas of the breast METHODS: Syk expression was examined in invasive carcinomas of the breast and in corresponding premalignant epithelial lesions in 50 women, using immunohistochemical method and semi-quantitative scoring system (H-score). 15861514 Human
syk carcinoma in situ RESULTS: Syk was strongly and uniformly expressed in normal mammary epithelium (H score=2.36-/+0.75), and no significant reduction in Syk expression was observed in hyperplastic lesions (H=2.31-/+0.87), carcinoma in situ (H=1.90-/+0.93), or invasive carci 15861514 Human
syk hyperplastic RESULTS: Syk was strongly and uniformly expressed in normal mammary epithelium (H score=2.36-/+0.75), and no significant reduction in Syk expression was observed in hyperplastic lesions (H=2.31-/+0.87), carcinoma in situ (H=1.90-/+0.93), or invasive carci 15861514 Human
syk invasive carcinomas RESULTS: Syk was strongly and uniformly expressed in normal mammary epithelium (H score=2.36-/+0.75), and no significant reduction in Syk expression was observed in hyperplastic lesions (H=2.31-/+0.87), carcinoma in situ (H=1.90-/+0.93), or invasive carci 15861514 Human
syk carcinomas CONCLUSION: The loss of Syk characterizes a subset of breast carcinomas but does not apparently contribute to the development of the metastatic potential of these carcinomas, limiting the potential diagnostic utility of immunohistochemical test in the pre 15861514 Human
syk breast carcinomas CONCLUSION: The loss of Syk characterizes a subset of breast carcinomas but does not apparently contribute to the development of the metastatic potential of these carcinomas, limiting the potential diagnostic utility of immunohistochemical test in the pre 15861514 Human
syk breast cancer [Spleen tyrosine kinase (L) suppresses breast cancer development by downregulating the expression of cyclin D1, ID1, B-myb and Fra1] OBJECTIVE: To screen the target genes regulated by the transcriptional repressor Syk (L) so as to explore the mechanism of 17418011 Human
syk breast cancer Syk negative breast cancer cells of the line MB231 were cultured and infected with adeno-Syk (L), adeno-Syk (S), and the control adeno-Lac Z respectively. cDNA microarray was used to screen the genes regulated by Syk (L) and Syk (S). 17418011 Human
syk oncogenes RESULTS: The transcriptional repressor Syk (L) was able to down-regulate the expression of the oncogenes ID1, cyclin D1, Fra1, and B-myb in the breast cancer cells. 17418011 Human
syk breast cancer RESULTS: The transcriptional repressor Syk (L) was able to down-regulate the expression of the oncogenes ID1, cyclin D1, Fra1, and B-myb in the breast cancer cells. 17418011 Human
syk oncogenes CONCLUSION: Syk (L) suppresses the progression of breast cancer by down regulating the expression of the oncogenes ID1, cyclin D1, Fra1, and B-myb. 17418011 Human
syk breast cancer CONCLUSION: Syk (L) suppresses the progression of breast cancer by down regulating the expression of the oncogenes ID1, cyclin D1, Fra1, and B-myb. 17418011 Human
syk breast cancer This study was to explore the mechanism of Syk(L) regulated gene transcription in breast cancer cells. 17672934 Human
syk breast cancer The binding of endogenous HDAC1 and Syk(L) in breast cancer cell line MB468 was also detected by immunoprecipitation. 17672934 Human
syk breast cancer CONCLUSIONS: Syk(L) regulates gene transcription in breast cancer by binding with HDACs to form transcription repressive complexes. 17672934 Human
syk neoplasms [Functions of spleen tyrosine kinase (Syk) gene and its correlation to neoplasms] Spleen tyrosine kinase (Syk) was thought to be a hematopoietic cell-specific signaling molecule and plays an essential role in maturation of lymphocytes and activation of im 17672952 Human
syk tumors Down-regulation of Syk expression was first observed during breast cancer progression, now its abnormal expression has also been detected in many other types of tumors. 17672952 Human
syk breast cancer Down-regulation of Syk expression was first observed during breast cancer progression, now its abnormal expression has also been detected in many other types of tumors. 17672952 Human
syk tumorigenesis Syk could suppress tumorigenesis and metastasis, but the molecular mechanism remains unknown. 17672952 Human
syk metastasis Syk could suppress tumorigenesis and metastasis, but the molecular mechanism remains unknown. 17672952 Human
syk metastasis Increasing clinical evidences reveal a positive correlation of reduced Syk expression to increased risk for metastasis, and indicate that Syk may be a potential new tumor suppressor. 17672952 Human
syk intestinal tumors In contrast, Compound DDE24, a synthetically activated genistein, an inhibitor of Epidermal Growth Factor receptor (EGF-R), cellular homologue of oncogene product from Raus Avian sarcoma virus (SRC) and Syk tyrosine kinases, which Thus, selective targetin 17688077 Mouse
syk squamous cell carcinomas of the head and neck Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck. 17699797 Human
syk breast cancers In breast cancers, reduced Syk expression was associated with invasion, and its overexpression in cell lines was shown to inhibit cell motility. 17699797 Human
syk nasopharyngeal carcinoma In contrast, Syk has been shown to mediate chemomigration in nasopharyngeal carcinoma cells. 17699797 Human
syk tumors Higher levels of Syk expression were observed in tumors and lymph node metastases relative to normal tissues. 17699797 Human
syk lymph node metastases Higher levels of Syk expression were observed in tumors and lymph node metastases relative to normal tissues. 17699797 Human
spleen tyrosine kinase breast cancer [Spleen tyrosine kinase (L) suppresses breast cancer development by downregulating the expression of cyclin D1, ID1, B-myb and Fra1] OBJECTIVE: To screen the target genes regulated by the transcriptional repressor Syk (L) so as to explore the mechanism of 17418011 Human
spleen tyrosine kinase breast cancer [Biological mechanism of full-length form of spleen tyrosine kinase regulating gene transcription in breast cancer cells] BACKGROUND & OBJECTIVE: Full-length form of spleen tyrosine kinase [Syk(L)] is a tumor suppressor gene in breast cancer, which may tr 17672934 Human
spleen tyrosine kinase neoplasms [Functions of spleen tyrosine kinase (Syk) gene and its correlation to neoplasms] Spleen tyrosine kinase (Syk) was thought to be a hematopoietic cell-specific signaling molecule and plays an essential role in maturation of lymphocytes and activation of im 17672952 Human
syk primary breast cancer The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study. 17874182 Human
syk metastatic breast cancer INTRODUCTION : We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer. 17874182 Human
syk operable breast cancer METHODS : Immunohistochemical staining was performed for S100A2, SYK and STMN1 on a tissue microarray containing ER-positive invasive breast carcinomas from a study cohort of 215 operable breast cancer patients, who underwent radical local therapy and who 17874182 Human
syk invasive breast carcinomas METHODS : Immunohistochemical staining was performed for S100A2, SYK and STMN1 on a tissue microarray containing ER-positive invasive breast carcinomas from a study cohort of 215 operable breast cancer patients, who underwent radical local therapy and who 17874182 Human
syk primary tumors Herein, we assess the role of SYK-dependent tonic BCR survival signals in DLBCL cell lines and primary tumors and evaluate the efficacy of an ATP-competitive inhibitor of SYK, R406, in vitro. 18006696 Human
syk dlbcl Herein, we assess the role of SYK-dependent tonic BCR survival signals in DLBCL cell lines and primary tumors and evaluate the efficacy of an ATP-competitive inhibitor of SYK, R406, in vitro. 18006696 Human
syk human breast cancer [Construction of the eukaryotic expression vector of human syk and its effect on MHC-I expression of human breast cancer cells.] AIM: To construct the eukaryotic expression vector of human spleen tyrosine kinase (Syk) and study the effect of Syk on MHC-I 18177606 Human
syk human breast cancer METHODS: A CDS fragment of human syk was obtained by RT-PCR from human breast cancer cells MDA-MB-468 and then the fragment was cloned into the expression vector pcDNA3.1D/V5-His-TOPO. 18177606 Human
syk adenocarcinomas To gain more detailed insight into the histogenesis of primary nonurachal adenocarcinomas and signet ring cell carcinomas of the urinary bladder, we analyzed by immunohistochemistry the expression of a broad panel of proteins, associated with cell differe 18283638 Human
syk tumor To gain more detailed insight into the histogenesis of primary nonurachal adenocarcinomas and signet ring cell carcinomas of the urinary bladder, we analyzed by immunohistochemistry the expression of a broad panel of proteins, associated with cell differe 18283638 Human
syk signet ring cell carcinomas To gain more detailed insight into the histogenesis of primary nonurachal adenocarcinomas and signet ring cell carcinomas of the urinary bladder, we analyzed by immunohistochemistry the expression of a broad panel of proteins, associated with cell differe 18283638 Human
syk adenocarcinomas The tumor suppressor genes showed a loss of protein expression in adenocarcinomas, ranging from 54.5% (14-3-3 sigma), to 31.8 (PTEN), 27.3% (SYK) and 18.2% (maspin). 18283638 Human
syk peripheral t-cell lymphomas Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. 18401419 Human
syk ptcl Overexpression of Syk, phosphorylation of its Y525/526 residues and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL. 18401419 Human
syk human breast carcinoma It has recently been reported that Syk, a non-receptor protein tyrosine kinase, functions as a potent tumour suppressor in human breast carcinoma. 18420802 Human
syk human hepatoma The possible interaction between HCV proteins and Syk in human hepatoma-derived Huh-7 cells was then examined. 18420802 Human
syk carcinogenesis The results indicate that NS5A may be involved in the carcinogenesis of hepatocytes through the suppression of Syk kinase activities. 18420802 Human
syk human leukemia Expression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human leukemia characterized by B cell accumulation. 18465772 Human
syk chronic lymphocytic leukemia Expression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human leukemia characterized by B cell accumulation. 18465772 Human
syk cm As compared with CD4 CM cells, EM cells express statistically significant increased amounts of SLP-76 and reduced levels of c-Cbl, Syk, Fyn, and LAT. 18505781 Human
syk lymphoma In contrast, the activity of two downstream signaling molecules, Syk and phospholipase Cgamma2 (PLCgamma2), are well correlated with cell line sensitivity to dasatinib, suggesting that these molecules are crucial in mediating the proliferation of activate 18596745 Human
syk hepatocellular carcinoma We retrospectively analyzed CpG island hypermethylation of the p14, p15, p16, GSTP1, integrin alpha4, SYK, and CDH1 genes in fresh-frozen tissues from 265 patients with hepatocellular carcinoma using the methylation-specific PCR. 18723830 Human
syk colorectal cancer [Association between hypermethylation of Syk gene and clinicopathological characteristics in colorectal cancer patients] OBJECTIVE: To investigate the association of the methylation status and expression level of Syk gene with the clinicopathological char 18803050 Human
syk colorectal cancer (crc) [Association between hypermethylation of Syk gene and clinicopathological characteristics in colorectal cancer patients] OBJECTIVE: To investigate the association of the methylation status and expression level of Syk gene with the clinicopathological char 18803050 Human
syk cancer METHODS: Methylation-specific PCR(MSP) and RT-PCR techniques were used to analyze the methylation status and expression level of Syk gene in cancer and normal tissues of 120 CRC patients, meanwhile, association of the methylation status and expression lev 18803050 Human
syk cancer RESULTS: (1) Syk gene expression was not found in 48 cancer tissues out of 120 patients and was found in all the normal tissues.The difference was significant. 18803050 Human
syk colorectal cancer CONCLUSION: Hypermethylation leads to silence of Syk gene involved in the initiation of colorectal cancer, which increases the infiltration of colorectal cancer cells, postoperative relapse and decreases the postoperative 3-year survival time. 18803050 Human
spleen tyrosine kinase metastatic breast cancer INTRODUCTION : We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer. 17874182 Human
spleen tyrosine kinase human breast cancer [Construction of the eukaryotic expression vector of human syk and its effect on MHC-I expression of human breast cancer cells.] AIM: To construct the eukaryotic expression vector of human spleen tyrosine kinase (Syk) and study the effect of Syk on MHC-I 18177606 Human
syk casitas b-lineage lymphoma Here we further report that stimulation with GM-CSF causes phosphorylation of Syk protein kinase, but neither Casitas B-lineage lymphoma (Cbl) nor Cbl-b in CD34(+) hemopoietic progenitors can be blocked by anti-CD116 mAb. 11591765 Human
syk rat basophilic leukemia We illustrate the value of the model in analyzing experimental data by using it to show that the intrinsic rate of dephosphorylation of the FcepsilonRI gamma immunoreceptor tyrosine-based activation motif (ITAM) in rat basophilic leukemia (RBL) cells is m 12217386 Rat
syk tumor RESULTS: The expression of Wnt-5a and Syk correlated in four of five tumor cell lines. 15701836 Human
syk tumor AIM: To analyze the expression of Syk tyrosine kinase, recently implicated as a tumor suppressor in mammary carcinogenesis, during the multi step development of human breast carcinoma. 15861514 Human
syk acute lymphoblastic leukemia We evaluated the expression of 2 members of the Syk family, ZAP-70 and Syk, in acute lymphoblastic leukemia (ALL) samples, using data derived from a series of 33 T-ALL and 95 B-lineage adult ALL patients analyzed by oligonucleotide arrays. 16160012 Human
syk transitional cell carcinomas To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG dinucleotides at 5' promoter regions, we analysed the methylation status of a broad panel of different genes in transiti 16964403 Human
syk tumor Increasing clinical evidences reveal a positive correlation of reduced Syk expression to increased risk for metastasis, and indicate that Syk may be a potential new tumor suppressor. 17672952 Human

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