tie-2 |
tumor |
Tumor morphology, vascular architecture and the expression of VEGF, Ang-1, Ang-2 and Tie-2 were examined by immunohistochemistry and semi-quantitative RT-PCR. |
15015569 |
Human |
tie-2 |
tumor |
In vivo, expression of the transgene resulted in prolonged survival and reduction of tumor volume (62%) and reduced the expression of VEGF (57.8%) and Tie-2 (15.4%) but not Ang-1 and Ang-2. |
15015569 |
Rat |
tie2 |
epithelial ovarian cancer |
Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer. |
15047239 |
Human |
tie2 |
tumors |
OBJECTIVES: Angiopoietin/Tie2 system with vascular endothelial growth factor (VEFG) is known to be important for the initiation of angiogenesis in tumors. |
15047239 |
Human |
tie2 |
epithelial ovarian cancer |
The aim was to evaluate whether angiopoietin/Tie2 system with VEFG affects prognosis in patients of epithelial ovarian cancer. |
15047239 |
Human |
tie2 |
epithelial ovarian cancer |
METHODS: Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Tie2, and VEGF gene expression were analyzed by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) in 85 epithelial ovarian cancer surgical specimens. |
15047239 |
Human |
tie2 |
epithelial ovarian cancer |
CONCLUSIONS: Angiogenesis occurred by angiopoietin/Tie2 system in concert with VEGF in epithelial ovarian cancer did not affect patients' survival. |
15047239 |
Human |
tie2 |
hepatocellular carcinoma |
Tie2 vascular endothelial receptor expression and function in hepatocellular carcinoma. |
11915032 |
NA |
tie2 |
tumors |
The Tie2 receptor protein was overexpressed in the neovascular endothelium of 31 of 39 (80%) human HCC tumors by immunohistochemical analysis with significant correlation to cell dedifferentiation and tumor size (P <.05). |
11915032 |
Human |
tie2 |
tumor |
The Tie2 receptor protein was overexpressed in the neovascular endothelium of 31 of 39 (80%) human HCC tumors by immunohistochemical analysis with significant correlation to cell dedifferentiation and tumor size (P <.05). |
11915032 |
Human |
tie2 |
tumor |
Inhibition of the Ang/Tie2 signal transduction cascade is a promising approach for tumor treatment. |
11915032 |
Human |
tie-2 |
thyroid tumors |
Tie-2 and angiopoietin-1 expression in human thyroid tumors. |
11916292 |
NA |
tie-2 |
thyroid tumor |
Although its expression is considered to be restricted to vascular endothelial cells and hematopoietic progenitors, our immunohistochemical and in situ hybridization studies showed that Tie-2 and its ligand, angiopoietin (Ang)-l were expressed not only in |
11916292 |
Human |
tie-2 |
tumor |
To confirm the expression in these tissues further, we used a laser capture microdissection system to isolate epithelial tumor cells from tissue specimens selectively, and demonstrated the expression of Tie-2 and Ang-1 mRNAs in tumor cells by RT-PCR analy |
11916292 |
NA |
tie2 |
tumor |
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. |
11943723 |
Human |
tie2 |
squamous-cell carcinoma |
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. |
11943723 |
Human |
tie2 |
tumor |
The distinct roles of angiopoietin (Ang)-1 and Ang2, counteracting ligands for the endothelium-specific Tie2 receptor, in tumor development and progression have remained poorly understood. |
11943723 |
NA |
tie2 |
tumors |
Stable overexpression of Ang1 in human A431 SCCs resulted in a more than 70% inhibition of tumor growth, associated with enhanced Tie2 phosphorylation levels, as compared with low levels in control transfected tumors. |
11943723 |
Human |
tie2 |
tumor |
Stable overexpression of Ang1 in human A431 SCCs resulted in a more than 70% inhibition of tumor growth, associated with enhanced Tie2 phosphorylation levels, as compared with low levels in control transfected tumors. |
11943723 |
Human |
tie-2 |
hepatoma |
The Tie-2, c-Met, and Flk-1 genes were the most abundant RTK genes cloned in rat hepatoma compared to normal liver. |
11956651 |
Rat |
tie-2 |
hepatoma |
Tie-2 ligand, angiopointin-1, mRNA was detected in both normal livers and hepatoma cells/tissues. |
11956651 |
Rat |
tie-2 |
papillary thyroid carcinoma |
EXPERIMENTAL DESIGN: We investigated immunohistochemically the expression patterns and levels of antiangiogenic factor and its receptor, thrombospondin-1 (TSP-1) and CD36, and four angiogenic factors, vascular endothelial growth factor (VEGF), VEGF-C, ang |
12006528 |
Human |
tie2 |
ovarian cancer |
Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer. |
12138242 |
NA |
tie2 |
ovarian cancer |
METHODS: Ang1, Ang2, and Tie2 gene expression in 14 normal ovaries with corpus luteum (CL) and in 19 cases of ovarian cancer were analyzed by polymerase chain reaction of RNA after reverse transcription. |
12138242 |
NA |
tie2 |
ovarian cancer |
Moreover, Ang2 gene expression showed no significant correlation with the Tie2 gene expression either in normal ovary with CL or in ovarian cancer. |
12138242 |
Human |
tie2 |
tumor |
Tie2 expression was positive primarily in the endothelial cells around CL and in those at the periphery of tumor invasion. |
12138242 |
Human |
tie-2 |
tumor |
At different stages of tumor growth, the histological aspects were described and sections were immunostained for VEGF, Ang-2 and their receptors VEGFR-1, VEGFR-2 and Tie-2. |
12174896 |
NA |
tie-2 |
tumor |
RESULTS: Ang-2 and Tie-2 were detected in the endothelial cells of vessels surrounded by tumor cells, occuring early in our study, with immunostaining taking place from day 4 to day 24. |
12174896 |
Rat |
tie-2 |
head and neck squamous cell carcinoma |
Soluble Tie-2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma. |
12203803 |
Human |
tie-2 |
head and neck squamous cell carcinoma |
BACKGROUND: This study assessed two circulating angiogenic receptors as tumor markers in patients with head and neck squamous cell carcinoma (HNSCC): soluble vascular endothelial factor growth receptor-1 (sVEGFR1) and soluble Tie-2 receptor (sTie2R). |
12203803 |
Human |
tie-2 |
tumor |
BACKGROUND: This study assessed two circulating angiogenic receptors as tumor markers in patients with head and neck squamous cell carcinoma (HNSCC): soluble vascular endothelial factor growth receptor-1 (sVEGFR1) and soluble Tie-2 receptor (sTie2R). |
12203803 |
Human |
tie2 |
tumor angiogenesis |
Tie2 is an endothelial receptor tyrosine kinase that is required for both embryonic vascular development and tumor angiogenesis. |
12082108 |
Human |
tie2 |
lobular capillary hemangioma |
Expression of the endothelial receptor tyrosine kinase Tie2 in lobular capillary hemangioma of the oral mucosa: an immunohistochemical study. |
12227329 |
Human |
tie2 |
renal clear cell carcinomas |
Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. |
12434420 |
Human |
tie2 |
human renal-cell carcinomas |
To determine the significance and regulation of the angiopoietin (Ang) pathway in highly vascular human renal cell carcinomas (RCCs), this study has investigated the expression of the Ang-1, Ang-2, Ang-4, and Tie2 genes in a series of normal (n = 26) and |
12434420 |
NA |
tie2 |
tumour |
Ang-1, Ang-2 and Tie2, but not Ang-4 mRNA, were detected in normal and tumour samples. |
12434420 |
Human |
tie2 |
tumour |
Immunohistochemistry for Ang-2 showed strong expression in vascular endothelium and weak expression in tumour cells, whereas Tie2 was expressed exclusively on endothelium. |
12434420 |
Human |
tie2 |
cancers |
Tie2 gene expression was positively correlated with Ang-2 expression in cancers (p = 0.001) and showed a borderline significant association with Ang-1 (p = 0.06), but there was no significant relationship between Ang-1 and Ang-2 (p = 0.69). |
12434420 |
Human |
tie2 |
clear-cell carcinomas |
No significant relationships were observed in clear cell carcinomas between Ang-1, Ang-2 and Tie2 mRNA abundance and patient sex, patient age, or tumour size (p > 0.05). |
12434420 |
Human |
tie2 |
tumour |
No significant relationships were observed in clear cell carcinomas between Ang-1, Ang-2 and Tie2 mRNA abundance and patient sex, patient age, or tumour size (p > 0.05). |
12434420 |
Human |
tie2 |
tumours |
These data suggest that it is endothelial induction of Ang-2 in tumours that regulates vessel stability and supports targeting Tie2 as an effective novel anti-angiogenic therapy in clear cell RCCs. |
12434420 |
Human |
tie2 |
human breast cancer |
Moreover, Tie2 was upregulated in the endothelium of vascular "hot spots" in human breast cancer specimens. |
14749497 |
Human |
tie2 |
tumor |
To determine the functional role of Tie2 in tumor vasculature, a soluble Tie2 extracellular domain (ExTek) was designed that blocked the activation of Tie2 by its activating ligand, angiopoietin 1 (Ang1). |
14749497 |
Human |
tie2 |
metastasis |
Administration of recombinant ExTek protein or an ExTek adenovirus inhibited tumor growth and metastasis in rodent tumor models, demonstrating a functional role for Tie2 in pathological angiogenesis in adult tissues. |
14749497 |
Mouse |
tie2 |
tumor |
Administration of recombinant ExTek protein or an ExTek adenovirus inhibited tumor growth and metastasis in rodent tumor models, demonstrating a functional role for Tie2 in pathological angiogenesis in adult tissues. |
14749497 |
Mouse |
tie-2 |
tumor |
By immunohistochemical staining of tumor cells from 26 patients, VEGFR-1 was detected in 24 (92%), VEGFR-2 in five (19%), Tie-2 in 14 (54%), and c-Met, a specific receptor of hepatocyte growth factor (HGF) in 23 patients (88%). |
12588446 |
Human |
tie-2 |
tumor |
Comparative studies of WIBC-9, three established non-IBC xenografts, and a human breast cancer cell line (SK-BR3) by reverse transcription-PCR, ELISA, and immunohistochemistry indicated that certain human genes (interleukin 8, vascular epidermal growth fa |
11212228 |
Human |
tie-2 |
human breast cancer |
Comparative studies of WIBC-9, three established non-IBC xenografts, and a human breast cancer cell line (SK-BR3) by reverse transcription-PCR, ELISA, and immunohistochemistry indicated that certain human genes (interleukin 8, vascular epidermal growth fa |
11212228 |
Human |
tie2 |
tumor angiogenesis |
Tie2 is an endothelium-specific receptor tyrosine kinase known to play an important role in tumor angiogenesis. |
14985112 |
Human |
tie2 |
tumor |
Via mouse tail vein injection, 125I-labeled GA3 was found to favorably accumulate in SPC-A1 xenograft tumor tissues which positively express Tie2. |
14985112 |
Human |
tie2 |
tumor angiogenesis |
Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants. |
11169947 |
Human |
tie2 |
human tumors |
Human tumors expressed VEGFR-2 and tie2 but varied considerably in VEGF and angiopoietin-1/-2 expression. |
11169947 |
Human |
tie2 |
tumors |
M6363 and M6378 tumors were analyzed in detail because they showed different expression of components of the tie2/angiopoietin signaling system. |
11169947 |
Mouse |
tie2 |
tumors |
M6363 tumors expressed VEGF, VEGFR-2 and angiopoietin-2 but not tie2 or angiopoietin-1, suggesting activation of VEGFR-2 and inhibition of tie2 signaling pathways, whereas M6378 tumors expressed VEGF, VEGFR-2, tie2 and angiopoietin-1 but little angiopoiet |
11169947 |
Mouse |
tie2 |
tumor |
In vivo studies using truncated dominant-negative tie2 and VEGFR-2 mutants revealed inhibition of M6363 tumor growth by 15% (truncated tie2) and 36% (truncated VEGFR-2), respectively. |
11169947 |
Mouse |
tie2 |
tumor |
In contrast, M6378 tumor growth was inhibited by 57% (truncated tie2) and 47% (truncated VEGFR-2), respectively. |
11169947 |
Mouse |
tie-2 |
cancer |
Angiopoietin (Ang)-2 (the natural antagonist for the angiogenic Tie-2 receptor) and vascular endothelial growth factor (VEGF) are thought to be critical regulators in this process; therefore, these may play a critical role in cancer aggressiveness. |
11280779 |
Human |
tek |
tumor |
Ang2 expression in the highly proliferative tumor vascular endothelium was also increased, as was phosphorylated Tie2/Tek. |
11305411 |
Human |
tie2 |
tumor |
Ang2 expression in the highly proliferative tumor vascular endothelium was also increased, as was phosphorylated Tie2/Tek. |
11305411 |
Human |
tie2 |
tumors |
To define a role for the angiopoietin/Tie2 system in astrocytoma angiogenesis, we examined the expression of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) in these tumors by immunohistochemistry and in situ hybridization. |
11304469 |
Human |
tie2 |
astrocytoma |
To define a role for the angiopoietin/Tie2 system in astrocytoma angiogenesis, we examined the expression of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) in these tumors by immunohistochemistry and in situ hybridization. |
11304469 |
Human |
tie2 |
breast tumors |
Because there are only limited data on the Tie2 pathway in human breast cancer, and our previous data have suggested that breast tumors establish a blood supply by vascular remodeling, we have investigated the expression of Ang-1, Ang-2, Ang-4, and Tie2 i |
11309342 |
Human |
tie2 |
human breast cancer |
Because there are only limited data on the Tie2 pathway in human breast cancer, and our previous data have suggested that breast tumors establish a blood supply by vascular remodeling, we have investigated the expression of Ang-1, Ang-2, Ang-4, and Tie2 i |
11309342 |
Human |
tie2 |
tumor |
RESULTS: Ang-1, Ang-2, Ang-4, and Tie2 were detected in 19%, 52%, 35%, and 65%, respectively, of tumor samples. |
11309342 |
Human |
tie2 |
tumor |
There was a significant reduction in expression of tumor Ang-1 (P = 0.04), Ang-2 (P = 0.01), Ang-4 (P = 0.004), and Tie2 (P = 0.02) compared with that in normal breast tissues. |
11309342 |
Human |
tie2 |
tumors |
There was a significant relationship in tumors between all Angs and between each ligand and Tie2. |
11309342 |
Human |
tie2 |
breast tumor |
CONCLUSIONS: These findings suggest that the Ang/Tie2 pathway plays a significant role in human breast tumor angiogenesis but provide no initial evidence for direct regulation of the pathway by estrogen. |
11309342 |
Human |
tie2 |
non-small cell lung cancer |
Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer. |
11350896 |
Human |
tie2 |
tumor |
The localizations of Ang-1, Ang-2, and TIE2 were confirmed within tumor cells immunohistochemically. |
11350896 |
Human |
tie2 |
renal cancer |
Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy. |
11448916 |
Human |
tie2 |
glioma |
Serial sections of 32 human glioma tissues (14 glioblastomas, eight anaplastic astrocytomas, seven astrocytomas, and three pilocytic astrocytomas) were immunostained against Ang2, vascular endothelial growth factor, Tie2, von Willebrand factor, and alpha |
11507079 |
Human |
tie-2 |
experimental melanoma |
Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma. |
11725211 |
Human |
tie-2 |
tumour |
Angiopoietin-1, angiopoietin-2 and Tie-2 in tumour and non-tumour tissues during growth of experimental melanoma. |
11725211 |
Human |
tie-2 |
tumour |
Angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and their tyrosine kinase receptor Tie-2 have been shown to play an important role in the processes of growth and remodelling of normal as well as tumour vessels. |
11725211 |
Human |
tie-2 |
experimental melanoma |
We studied gene expression of the angiogenic factors Ang-1 and Ang-2 and of their tyrosine kinase receptor Tie-2 in the tumour and non-tumour tissues of mice bearing the experimental melanoma B16. |
11725211 |
Human |
tie-2 |
tumour |
We studied gene expression of the angiogenic factors Ang-1 and Ang-2 and of their tyrosine kinase receptor Tie-2 in the tumour and non-tumour tissues of mice bearing the experimental melanoma B16. |
11725211 |
Human |
tie-2 |
tumour |
Using semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR we measured Ang-1, Ang-2 and Tie-2 mRNA levels in the tumour, bone marrow, liver and spleen. |
11725211 |
Human |
tie2 |
ovarian cancer |
Expression of TP and TIE2 genes in normal ovary with corpus luteum and in ovarian cancer: correlation with ultrasound-derived peak systolic velocity. |
10729313 |
Human |
tie2 |
ovarian cancer |
TP gene expression was significantly higher in ovarian cancer than in normal ovary with CL (P = 0.02), while TIE2 gene expression was not significantly different (P = 0.186). |
10729313 |
Human |
tie2 |
ovarian cancer |
There was a significant correlation between TIE2 gene expression and PSV in the normal ovary with CL (r = 0.633, P = 0.015), while TP expression was significantly correlated with the PSV in ovarian cancer (r = 0.757, P = 0.018). |
10729313 |
Human |
tie-2 |
tumor |
Angiopoietin-1 (Ang-1) stimulates endothelial and vascular network differentiation through the Tie-2 receptor tyrosine kinase, while Ang-2 modulates this activation in embryo and tumor growth. |
10820169 |
Human |
tie2 |
angiosarcoma |
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. |
10854238 |
Human |
tie2 |
kaposi's sarcoma |
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. |
10854238 |
Human |
tie2 |
angiosarcoma |
In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS |
10854238 |
Human |
tie2 |
tumor |
Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. |
10854238 |
Human |
tie2 |
non-small cell lung carcinomas |
The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. |
10880843 |
Human |
tie2 |
lung cancers |
We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal l |
10880843 |
Human |
tie2 |
non-small cell lung cancers |
We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal l |
10880843 |
Human |
tie2 |
carcinomas |
On the other hand, normal lung expressed constitutively high and correlated levels of Ang-1 and Tie2, which were significantly reduced in the carcinomas. |
10880843 |
Human |
tie-2 |
pyogenic granuloma |
Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. |
10929871 |
Human |
tie-2 |
pyogenic granuloma |
The purpose of this study was to detect and compare the expressions of Tie-2, Ang-1, Ang-2, ephrin-B2 and Eph-B4 among pyogenic granuloma on human gingiva, gingiva diagnosed with periodontitis and healthy gingiva by immunohistochemistry. |
10929871 |
Human |
tie2 |
tumor angiogenesis |
Angiopoietin-mediated modulation of Tie2 activation contributes to normal vessel development and stability, however, its role in tumor angiogenesis is not well known. |
14742253 |
Human |
tie2 |
malignant astrocytomas |
We investigated the role of Tie2 activation in malignant astrocytomas, a common and highly vascularized primary human brain tumor. |
14742253 |
Human |
tie2 |
astrocytoma |
Inhibition of Tie2, using a kinase-deficient Tie2 construct, decreases growth of malignant human astrocytoma subcutaneous and intracranial xenografts. |
14742253 |
Human |
tie2 |
tumor |
Tie2 inactivation disrupted the tumor vascularity, with a decrease in microvascular density, increased presence of abnormally dilated vessels, and loss of interaction between endothelial cells and surrounding smooth muscle cells, all collectively resultin |
14742253 |
Human |
tie2 |
tumor angiogenesis |
Overall, these findings strongly suggest that Tie2 activation contributes significantly to astrocytoma tumor angiogenesis and growth. |
14742253 |
Human |
tie2 |
astrocytoma |
Overall, these findings strongly suggest that Tie2 activation contributes significantly to astrocytoma tumor angiogenesis and growth. |
14742253 |
Human |
tek |
venous malformations |
Previously, we have described that venous malformations, localized bluish-purple skin lesions, are caused by an activating mutation in the TIE2/TEK receptor. |
10945476 |
Human |
tie2 |
venous malformations |
Previously, we have described that venous malformations, localized bluish-purple skin lesions, are caused by an activating mutation in the TIE2/TEK receptor. |
10945476 |
Human |
tie2 |
tumors |
Tie2 was shown to be upregulated in tumors and skin wounds, and its ligands angiopoietin-1 and -2, although they are not directly mitogenic, modulate neovascularization. |
10969034 |
Human |
tie2 |
tumor angiogenesis |
These findings indicate that at high concentrations, Ang2, like Ang1, can be an apoptosis survival factor for endothelial cells through the activation of the Tie2 receptor, PI 3'-kinase and Akt, and thus may be a positive regulator of tumor angiogene |
11002428 |
Human |
tie-2 |
arteriovenous malformations |
Abnormal pattern of Tie-2 and vascular endothelial growth factor receptor expression in human cerebral arteriovenous malformations. |
11014431 |
Human |
tie2 |
breast cancer |
Despite the expression of Ang1 in many human breast cancer cell lines, the gene was expressed in only three of 21 breast cancer clinical specimens, even though its receptor, Tie2, is abundant in the vasculature of all of these tumours. |
11027428 |
Human |
tie2 |
tumours |
Despite the expression of Ang1 in many human breast cancer cell lines, the gene was expressed in only three of 21 breast cancer clinical specimens, even though its receptor, Tie2, is abundant in the vasculature of all of these tumours. |
11027428 |
Human |
tie2 |
human breast cancer |
Despite the expression of Ang1 in many human breast cancer cell lines, the gene was expressed in only three of 21 breast cancer clinical specimens, even though its receptor, Tie2, is abundant in the vasculature of all of these tumours. |
11027428 |
Human |
tie-2 |
human prostate carcinoma |
The expression of angiopoietins and their receptor Tie-2 in human prostate carcinoma. |
11326698 |
Human |
tie-2 |
tumor |
Blood vessels close to the ducts and some apical tumor cells expressed angiopoietin-1 and Tie-2. |
11326698 |
Human |
tie2 |
malignant melanoma |
To determine whether angiogenesis and growth factor receptor expression are consistent findings in malignant melanoma, primary human melanomas were examined for mRNA expression of receptors for fibroblast growth factors (FGFR-1, FGFR-2), vascular endothel |
10541167 |
Human |
tie2 |
melanomas |
To determine whether angiogenesis and growth factor receptor expression are consistent findings in malignant melanoma, primary human melanomas were examined for mRNA expression of receptors for fibroblast growth factors (FGFR-1, FGFR-2), vascular endothel |
10541167 |
Human |
tie-2 |
b16 melanoma |
We investigated pre-angiogenic tumor cell survival and angiogenesis initiation by two murine tumor lines (4T1 mammary carcinoma and B16 melanoma), which constitutively expressed GFP, in dorsal skin-fold window chambers of mice treated with extracellular d |
14688196 |
Mouse |
tie-2 |
mammary carcinoma |
We investigated pre-angiogenic tumor cell survival and angiogenesis initiation by two murine tumor lines (4T1 mammary carcinoma and B16 melanoma), which constitutively expressed GFP, in dorsal skin-fold window chambers of mice treated with extracellular d |
14688196 |
Mouse |
tie-2 |
tumor |
We investigated pre-angiogenic tumor cell survival and angiogenesis initiation by two murine tumor lines (4T1 mammary carcinoma and B16 melanoma), which constitutively expressed GFP, in dorsal skin-fold window chambers of mice treated with extracellular d |
14688196 |
Mouse |
tie-2 |
venous malformations |
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. |
9926914 |
Human |
tie-2 |
venous malformations |
We also studied signaling by the R849W mutant of Tie-2 (MTie-2), which has been shown to cause venous malformations. |
9926914 |
Human |
tie-2 |
lymphangiomas |
The lymphangiomas developed in the peritoneal cavity and expressed the endothelial markers CD31/PECAM (platelet endothelial cell adhesion molecule), CD54/ICAM-1 (InterCellular Adhesion Molecule-1), and CD102/ICAM-2, as well as the vascular endothelial gro |
9925752 |
Mouse |
tie-2 |
tumor |
Expression patterns of the endothelial angiogenic receptors flt-1, flk-1, tie-1, and tie-2 were similar to those described in human gliomas, but flt-1 was expressed also in neoplastic astrocytes, suggesting an autocrine role in tumor growth. |
10027415 |
Mouse |
tie-2 |
tumor |
In crossbreeding experiments, hemizygous ablation of the tumor suppressor genes Rb and p53 had no significant effect on the expression of VEGF, flt-1, flk-1, tie-1, and tie-2. |
10027415 |
Mouse |
tek |
neoplasias |
Compared to normal tissues, in thyroid neoplasias we observed a consistent increase in vascular endothelial growth factor (VEGF), VEGF-C, and angiopoietin-2 and in their tyrosine kinase receptors KDR, Flt-4, and Tek. |
10595926 |
Human |
tie2 |
metastasis |
OBJECTIVE: To explore the effect of two dominating signaling pathways, VEGF/KDR and angiopoietins/Tie2, on the formation of new blood vessel in hepatocellular carcinoma (HCC) growth and metastasis. |
14627514 |
Human |
tie2 |
hepatoma |
Although significant difference in the expression of kinase insert domain containing receptor (KDR) and Ang1/Tie2 was not observed in all groups, their distinct high levels were seen in hepatoma and its margin compared with normal and cirrhotic liver. |
14627514 |
Human |
tie-2 |
cancer |
Tie-2 stabilises pericyte-endothelial interactions during angiogenesis and is highly expressed on endothelium during several diseases, including arthritis, age-related macular degeneration and cancer. |
15069689 |
Human |
tie-2 |
granulomas |
A total of 15 specimens, including granulomas taken from five gravidas during pregnancy, five after parturition, and five from normal gingiva were compared by immunoblot assays for their relative expressions of Ang-1, Ang-2, Tie-2, VEGF, and beta-actin. |
15089929 |
Human |
tie-2 |
granulomas |
The protein levels of Ang-2 and Tie-2 were highest in the granulomas in pregnancy, followed by those after parturition and normal gingiva, while Ang-1 and beta-actin exhibited no significant differences. |
15089929 |
Human |
tek |
myeloid leukemia |
Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid leukemia. |
11755466 |
NA |
tie2 |
venous malformations |
Of the two remaining families, one excludes linkage to the TIE2 locus, establishing the existence of at least one additional locus for dominantly inherited venous malformations. |
10369874 |
Human |
tie-2 |
melanoma |
Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. |
10397264 |
Human |
tie-2 |
tumor angiogenesis |
Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. |
10397264 |
Human |
tie-2 |
melanoma |
A375v human melanoma cells, which express at least the angiogenic growth factors VEGF, VEGF-C, and Ang-1, were stably transfected to overexpress the extracellular ligand-binding domains of the endothelium-specific receptor tyrosine kinases fms-like tyrosi |
10397264 |
Human |
tie-2 |
tumor |
Nude mouse xenografts revealed that interference with either the VEGF receptor pathway or the Tie-2 pathway resulted in a significant inhibition of tumor growth and tumor angiogenesis. |
10397264 |
Human |
tie-2 |
tumor angiogenesis |
Nude mouse xenografts revealed that interference with either the VEGF receptor pathway or the Tie-2 pathway resulted in a significant inhibition of tumor growth and tumor angiogenesis. |
10397264 |
Human |
tie-2 |
melanoma |
Our results show that both the VEGF receptor pathway and the Tie-2 pathway are essential for A375v melanoma xenograft growth. |
10397264 |
Human |
tie2 |
hepatocellular carcinoma |
Expression of angiopoietin-2 gene and its receptor Tie2 in hepatocellular carcinoma. |
12539584 |
Human |
tie2 |
tumor |
To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology of hepatocellular carcinoma (HCC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HCC, 8 cirrhotic and 8 |
12539584 |
Human |
tie2 |
tumor |
The level of Tie2 receptor expression in HCC was closely related with tumor diameter, angiogenesis and portal invasion. |
12539584 |
Human |
tie2 |
tumor |
In this review we summarize what is known of the biological role of Angiopoietins and Tie2, their interaction with VEGF in normal and tumor related angiogenesis, with emphasis on their functional consequence in the progression and growth of malignant huma |
12456344 |
Human |
tie2 |
non-small cell lung carcinomas |
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas. |
10499626 |
Human |
tie2 |
cancers |
Levels of Tie2, angiopoietin (Ang)-1, vascular endothelial growth factor (VEGF), and CD31 mRNAs were higher in cancers than in adjacent noncancerous tissues, in contrast to the fms-like tyrosine kinase (Flt)-1, Flt-4, Tie1, thrombin receptor, endoglin, an |
10499626 |
Human |
tek |
tumour |
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. |
9459145 |
Human |
tie2 |
tumour |
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. |
9459145 |
Human |
tek |
tumours |
In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in |
9459145 |
Human |
tie2 |
tumours |
In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in |
9459145 |
Human |
tie-2 |
tumours |
However, the strongest expression of Tie-2 was seen in vascular 'hot spots' within the inflammatory infiltrate at the periphery of invasive tumours. |
9459145 |
Human |
tie2 |
tumours |
Moreover, the proportion of Tie2-positive vessels (Tie2 counts/CD31 counts) was significantly higher in breast tumours than the proportion of Tie2-positive vessels in either normal breast tissue or benign breast lesions (P = 0.004 and 0.0001 respectively) |
9459145 |
Human |
tie2 |
tumour |
These data are consistent with a role for Tie2 in tumour angiogenesis and demonstrate the potential use of Tie2 expression as a novel marker of the tumour vasculature. |
9459145 |
Human |
tie2 |
tumor angiogenesis |
Tie2 is an endothelium-specific receptor tyrosine kinase that is required for both normal embryonic vascular development and tumor angiogenesis and is thought to play a role in vascular maintenance. |
9632797 |
Human |
tek |
tumor angiogenesis |
Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis. |
9671764 |
Human |
tie2 |
tumor angiogenesis |
Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis. |
9671764 |
Human |
tie2 |
tumor |
To assess the potential role of Tie2 and its ligands angiopoietin-1 and angiopoietin-2 in tumor vascularization, we analyzed their expression pattern in human gliomas. |
9811337 |
Human |
tie-2 |
tumor |
Tie-2 was up-regulated in tumor endothelium compared to normal human brain tissue. |
9811337 |
Human |
tie2 |
tumor angiogenesis |
Although the function of Tie2 and its ligands in tumor angiogenesis remains a subject of speculation, our findings are in agreement with a recently proposed hypothesis that in the presence of VEGF, local production of Ang-2 might promote angiogenesis. |
9811337 |
Human |
tie2 |
tumour |
Strong expression of Tie2 was seen in tumour vessels in accordance with Ang-2 expression. |
14600132 |
Human |
tie-2 |
megakaryoblastic leukaemia |
The coexpression of Tie-2 and angiopoietin-1 in megakaryoblastic leukaemia cell lines suggests the existence of an autocrine ligand/receptor signalling loop in these cells. |
9233584 |
Human |
tie-2 |
tumor angiogenesis |
The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture. |
14579791 |
Human |
tie-2 |
tumor |
The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture. |
14579791 |
Human |
tie-2 |
tumor |
The expression of Ang-1 and Tie-2 was more noticeable at the periphery of the tumor. |
14579791 |
Human |
tie2 |
tumor angiogenesis |
Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. |
9329972 |
Mouse |
tie2 |
cancer |
These data demonstrate a role for the Tie2 pathway in pathologic angiogenesis, suggesting that targeting this pathway may yield effective antiangiogenic agents for treatment of cancer and other angiogenic diseases. |
9329972 |
Human |
tie-2 |
breast carcinoma |
We attempted to determine if, through increased peripheral expression of AC133 or endothelial markers previously associated with EPCs,VEGFR-2 and Tie-2, we could detect an EPC response in the blood of patients with breast carcinoma. |
12878859 |
Human |
tie-2 |
cancer |
The cancer patients had significantly elevated Tie-2 expression with the highest levels associated with infiltrating carcinoma. |
12878859 |
Human |
tie-2 |
prostate cancer |
Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. |
14511360 |
Human |
tie-2 |
cancer |
MATERIALS AND METHODS: In order to further determine abnormalities in levels of Ang-1, Ang-2, Tie-2, sFlt-1 and VEGF in human cancer (and their interrelationships), these molecules were measured in plasma from 30 patients with breast cancer, 30 patients w |
14511360 |
Human |
tie-2 |
prostate cancer |
MATERIALS AND METHODS: In order to further determine abnormalities in levels of Ang-1, Ang-2, Tie-2, sFlt-1 and VEGF in human cancer (and their interrelationships), these molecules were measured in plasma from 30 patients with breast cancer, 30 patients w |
14511360 |
Human |
tie-2 |
breast cancer |
MATERIALS AND METHODS: In order to further determine abnormalities in levels of Ang-1, Ang-2, Tie-2, sFlt-1 and VEGF in human cancer (and their interrelationships), these molecules were measured in plasma from 30 patients with breast cancer, 30 patients w |
14511360 |
Human |
tie-2 |
breast cancer |
RESULTS: In breast cancer, levels of Ang-1 (P=0.0005), Ang-2 (P=0.0173), Tie-2 (P=0.0001), and VEGF (P=0.0001) were all significantly raised, and plasma levels of sFlt-1 (P=0.045) were significantly reduced compared with controls. |
14511360 |
Human |
tie-2 |
prostate cancer |
However, in prostate cancer, only levels of VEGF and Tie-2 were significantly higher (both P=0.001). |
14511360 |
Human |
tie-2 |
prostate cancer |
Significant correlations were found between levels of Ang-1 and Tie-2 both in breast (r=0.498, P=0.005) and prostate cancer (r=0.643, P=<0.001). |
14511360 |
Human |
tie-2 |
prostate cancer |
CONCLUSIONS: Abnormal levels of Ang-1, Ang-2 and their receptor, Tie-2, are present in breast and prostate cancer, and their interrelationships may be important in the pathophysiology of these conditions. |
14511360 |
Human |
tie-2 |
cancer |
Featured among the selected clones with b9 allotype is a rabbit/human Fab that binds with a dissociation constant of 1nM to both human and mouse Tie-2, which will facilitate its evaluation in mouse models of human cancer. |
12488098 |
Human |
tie-2 |
cancer |
In addition, agents targeting other tyrosine kinases implicated in cancer, such as Met, Tie-2 and Src, are in preclinical development. |
12517254 |
Human |
tie2 |
neoplasm |
However the prognostic significance of Tie2 has never been demonstrated in this neoplasm. |
12527939 |
Human |
tie2 |
breast carcinoma |
In order to establish the prognostic value of Tie2 in breast carcinoma, we investigated Tie2 expression in a large series of patients and correlated it with long-term follow-up. |
12527939 |
Human |
tie2 |
tumor |
Univariate (Kaplan-Meier) analysis showed that a large Tie2 positive tumor surface (cut off = 7%) was significantly correlated with poor overall survival (p=0.025). |
12527939 |
Human |
tie2 |
metastasis |
Tie2 expression correlated with high metastasis risk among all patients (p=0.00067) and among node negative ones as well (p=0.01). |
12527939 |
Human |
tie2 |
metastasis |
Tie2 expression permits identification of poor outcome patients, in particular node negative ones with high risk of metastasis and relapse. |
12527939 |
Human |
tek |
tumor |
These studies show that TEK signaling is indispensable for the development of the embryonic vasculature and suggest that TEK signaling may also be required for the development of the tumor vasculature. |
7478529 |
Mouse |
tie-2 |
schwannoma |
In the human sciatic nerve and schwannoma, RT-PCR, Western blotting and immunohistochemistry analysis further confirmed the presence of Tie-2 mRNA and protein in non-autonomic peripheral nervous tissue. |
12887596 |
Human |
tie-2 |
tumour |
Thus, attempts to disrupt the tumour vessels by manipulation of the Tie-2 system in tumours may result in side-effects in peripheral nerves. |
12887596 |
Human |
tie-2 |
tumours |
Thus, attempts to disrupt the tumour vessels by manipulation of the Tie-2 system in tumours may result in side-effects in peripheral nerves. |
12887596 |
Human |
tie2 |
tumor |
On intravenous delivery into tumor-bearing mice, the Tie2 vector targeted expression to the ECs of tumor vessels. |
12908970 |
Mouse |
tie2 |
tumor |
The previously reported upregulation of the Tie2 gene in ECs activated for angiogenesis may explain the remarkable selectivity of expression of the Tie2 vector in ECs of tumor vessels. |
12908970 |
Human |
tie-2 |
chronic myeloid leukaemia |
Expression of cox-2, tie-2 and glycodelin by megakaryocytes in patients with chronic myeloid leukaemia and polycythaemia vera. |
12716375 |
Human |
tie-2 |
polycythaemia vera |
Expression of cox-2, tie-2 and glycodelin by megakaryocytes in patients with chronic myeloid leukaemia and polycythaemia vera. |
12716375 |
Human |
tie-2 |
human hepatocellular carcinoma |
Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. |
12717391 |
Human |
tie-2 |
tumor angiogenesis |
In this study, we investigated the expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in surgically resected specimens from 46 patients with HCC to determine their potential role in tumor angiogenesis and its progression. |
12717391 |
Human |
tie-2 |
tumor |
METHODS: Since a link has been established in neoplasias between tumor growth and an increased expression of angiogenic growth factors, 136 samples of chorioangiomas and 136 samples of tumor-free placental tissue were examined in terms of proliferation ra |
12747234 |
Human |
tie-2 |
papilloma |
The study of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), ligands of receptor tyrosine kinase 2 (Tie-2), showed that while stroma-derived Ang-2 was increased, epidermal Ang-1 expression was completely abolished at early papilloma formation. |
12766907 |
Human |
tie2 |
tumor |
Unexpectedly, we did not find bone marrow-derived ECs in tumor vessels when we transplanted bone marrow progenitors constitutively expressing a marker gene from the Tie2 or ubiquitously active promoters. |
12740570 |
Human |
tie-2 |
human ovarian cancer |
In addition, a significant correlation was observed between VEGF and Ang-2 mRNA expression (P < 0.01) but not between VEGF and Ang-1 or Tie-2 in human ovarian cancer specimens. |
12810677 |
Human |
tie2 |
myeloma |
In a transwell coculture system, we observed that myeloma cells up-regulated the Ang-1 receptor Tie2 in human BM endothelial cells. |
12649156 |
Human |
tie2 |
tumor |
To inhibit angiogenesis, mice were immunized with dendritic cells (DCs) transfected with mRNA that encode products that are preferentially expressed during neoangiogenesis: vascular endothelial growth factor receptor-2 (VEGFR-2) and Tie2 expressed in prol |
12689940 |
Mouse |
tie2 |
melanoma |
Tumor growth was significantly inhibited in mice immunized against VEGF, VEGFR-2, and Tie2, either before tumor challenge or in the setting of pre-existing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models. |
12689940 |
Mouse |
tie2 |
tumor |
Tumor growth was significantly inhibited in mice immunized against VEGF, VEGFR-2, and Tie2, either before tumor challenge or in the setting of pre-existing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models. |
12689940 |
Mouse |
tie2 |
tumor |
Coimmunization of mice against VEGFR-2 or Tie2 and total tumor RNA exhibited a synergistic antitumor effect. |
12689940 |
Mouse |
tie-2 |
colorectal cancer |
Vascular endothelial growth factor and soluble Tie-2 receptor in colorectal cancer: associations with disease recurrence. |
12875855 |
Human |
tie-2 |
neoplasias |
METHODS: Since a link has been established in neoplasias between tumor growth and an increased expression of angiogenic growth factors, 136 samples of chorioangiomas and 136 samples of tumor-free placental tissue were examined in terms of proliferation ra |
12747234 |
Human |
tie-2 |
giant cell tumor of the tendon sheath |
Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: a possible role in synovial proliferation. |
11261813 |
Human |
tek |
breast tumour |
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. |
9459145 |
Human |
tek |
breast tumours |
In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in |
9459145 |
Human |
tek |
myeloproliferative disorders |
The expression of both the TEK receptor and its ligand in acute myeloid leukemia (AML) and CML patients might, therefore, suggest an involvement of these genes in the pathogenesis of myeloproliferative disorders. |
11755466 |
Human |
tek |
astrocytomas |
Targeting the Tie2/Tek receptor in astrocytomas. |
14742253 |
Human |
tek |
subcutaneous tumor |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Mouse |
tek |
metastases |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Mouse |
tek |
breast carcinoma |
The aim of this study was to investigate the prognostic value of vascular endothelial growth factor (VEGF) receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1), and Tie2/tek receptor tyrosine kinase in breast carcinoma. |
15753992 |
Human |
tie-2 |
gliomas |
Expression patterns of the endothelial angiogenic receptors flt-1, flk-1, tie-1, and tie-2 were similar to those described in human gliomas, but flt-1 was expressed also in neoplastic astrocytes, suggesting an autocrine role in tumor growth. |
10027415 |
Mouse |
tie-2 |
aml |
In this study, we examined the relationship between AML cells and endothelial cells by analyzing the expression profile of angiogenic factors, angiopoietin-1 (Ang-1), Ang-2, Tie-2 (a receptor for angiopoietins) and vascular endothelial growth factor (VEGF |
11840270 |
NA |
tie-2 |
hyperplastic |
Although its expression is considered to be restricted to vascular endothelial cells and hematopoietic progenitors, our immunohistochemical and in situ hybridization studies showed that Tie-2 and its ligand, angiopoietin (Ang)-l were expressed not only in |
11916292 |
Human |
tie-2 |
epithelial tumor |
To confirm the expression in these tissues further, we used a laser capture microdissection system to isolate epithelial tumor cells from tissue specimens selectively, and demonstrated the expression of Tie-2 and Ang-1 mRNAs in tumor cells by RT-PCR analy |
11916292 |
NA |
tie-2 |
hyperplastic |
CONCLUSIONS: A specific increase of Ang-1/Ang-2 ratio in FNH, in the presence of the functional Tie-2 receptor, might be involved in the formation of hyperplastic and dystrophic vessels of FNH. |
12612904 |
Human |
tie-2 |
malignancy |
The role of the tie-2 receptor has been extensively examined in neovascularization associated with malignancy, but little is known about the role it may play in atherosclerosis, a condition whose pathophysiology also involves angiogenesis. |
12814387 |
Human |
tie-2 |
tumor |
In a mouse model, in which the vascularization of a transplantable tumor was studied after bone marrow (BM) transplantation, we show that cells that express Tie-2, Sca-1, CD31 and CD45 function as both BM EPC and primitive hematopoietic stem cells. |
14757432 |
Mouse |
tie-2 |
cancer |
By means of a quantitative reverse transcription-PCR approach, we measured VE-cadherin (VE-C), Tie-2, vascular endothelial growth factor receptor 2 and CD133 RNA in the blood of 14 healthy controls, 3 pregnant women, and 84 newly diagnosed (or relapsed) c |
15205354 |
Human |
tie-2 |
cancer |
Conversely, circulating RNA levels of other endothelial or progenitor cell-specific markers Tie-2, vascular endothelial growth factor receptor 2, and CD133 were not significantly increased in either pregnant women or cancer patients. |
15205354 |
Human |
tie-2 |
colorectal cancer |
Changes in serum soluble VEGFR-1 and Tie-2 receptors in colorectal cancer patients following surgical resections. |
15330184 |
Human |
tie-2 |
tumour |
AIM: Determination of changes in serum levels of soluble (s) VEGFR-1 and Tie-2 receptors in colorectal cancer patients following resection in the search for novel tumour markers. |
15330184 |
Human |
tie-2 |
colorectal cancer |
AIM: Determination of changes in serum levels of soluble (s) VEGFR-1 and Tie-2 receptors in colorectal cancer patients following resection in the search for novel tumour markers. |
15330184 |
Human |
tie-2 |
tumor angiogenesis |
The essential roles of Ang-1 and Tie-2 in embryonic angiogenesis have been established, and studies have demonstrated the involvement of Ang-1 and Ang-2 in tumor angiogenesis. |
15342395 |
Human |
tie-2 |
tumor |
In addition, NVP-LAQ824 treatment inhibited the expression of angiogenesis-related genes such as angiopoietin-2, Tie-2, and survivin in endothelial cells and down-regulated hypoxia-inducible factor 1-alpha and VEGF expression in tumor cells. |
15374977 |
Human |
tie-2 |
hepatoma |
Angiopoietin-1 and Angiopoietin-2 were detected in hepatoma cells, hepatic stellate cells, and smooth muscle cells, whereas Tie-2 was detected in endothelial cells, hepatic stellate cells and smooth muscle cells. |
15094228 |
Human |
tie-2 |
pancreatic tumors |
Differential expression of the Tie-2 receptor and its ligands in human pancreatic tumors. |
15501112 |
Human |
tie-2 |
human tumors |
BACKGROUND: Derangements in the balance of the Tie-2 receptor ligands, angiopoietin-1 and angiopoietin-2 (Ang-1 and Ang-2), have been implicated in the growth and differentiation of several human tumors. |
15501112 |
Human |
tie-2 |
neuroendocrine tumors |
RESULTS: Microarray data showed that Ang-2 was upregulated in neuroendocrine tumors ( approximately 8 times more than normal) and adenocarcinoma of the pancreas ( approximately 5 times more than normal) although Ang-1 and Tie-2 were not differentially exp |
15501112 |
Human |
tie-2 |
adenocarcinoma of the pancreas |
RESULTS: Microarray data showed that Ang-2 was upregulated in neuroendocrine tumors ( approximately 8 times more than normal) and adenocarcinoma of the pancreas ( approximately 5 times more than normal) although Ang-1 and Tie-2 were not differentially exp |
15501112 |
Human |
tie-2 |
pancreatic tumors |
CONCLUSIONS: Although Tie-2 and Ang-1 are not differentially expressed in pancreatic tumors, Ang-2 gene and gene product are overexpressed, suggesting a significant role for Ang-2 in pancreatic tumorigenesis. |
15501112 |
Human |
tie-2 |
malignancy |
As the majority of previous research into Ang-2 and tie-2 has been in relation to angiogenesis and malignancy, the present study would suggest that Ang-2 and tie-2 may be used as potential indices of angiogenesis in diabetes mellitus (in addition to VEGF) |
15548809 |
Human |
tie-2 |
inflammatory breast cancer |
EXPERIMENTAL DESIGN: Real-time quantitative reverse transcriptase-PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis-related factors [vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF-D, Flt-1, KDR, Flt-4, Ang-1, An |
15585631 |
Human |
tie-2 |
tumor angiogenesis |
EXPERIMENTAL DESIGN: Real-time quantitative reverse transcriptase-PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis-related factors [vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF-D, Flt-1, KDR, Flt-4, Ang-1, An |
15585631 |
Human |
tie-2 |
breast cancer |
EXPERIMENTAL DESIGN: Real-time quantitative reverse transcriptase-PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis-related factors [vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF-D, Flt-1, KDR, Flt-4, Ang-1, An |
15585631 |
Human |
tie-2 |
tumor |
EXPERIMENTAL DESIGN: Real-time quantitative reverse transcriptase-PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis-related factors [vascular endothelial growth factor (VEGF)-A, VEGF-C, VEGF-D, Flt-1, KDR, Flt-4, Ang-1, An |
15585631 |
Human |
tie-2 |
inflammatory breast cancer |
RESULTS: Inflammatory breast cancer specimens had significantly higher mRNA expression levels than noninflammatory breast cancer specimens of the following genes: KDR (P = 0.033), Ang-1, (P = 0.0001), Tie-1 (P = 0.001), Tie-2 (P = 0.001), FGF-2 (P = 0.002 |
15585631 |
Human |
tie-2 |
breast cancer |
RESULTS: Inflammatory breast cancer specimens had significantly higher mRNA expression levels than noninflammatory breast cancer specimens of the following genes: KDR (P = 0.033), Ang-1, (P = 0.0001), Tie-1 (P = 0.001), Tie-2 (P = 0.001), FGF-2 (P = 0.002 |
15585631 |
Human |
tie-2 |
tumor angiogenesis |
As an endothelial cell-specific receptor kinase expressed almost exclusively on the surface of vascular endothelium, Tie-2 has an important role in tumor angiogenesis. |
15705898 |
Human |
tie-2 |
colorectal adenocarcinoma |
Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors. |
15742397 |
Human |
tie-2 |
colorectal adenocarcinomas |
The objective of this study was to establish a comprehensive Tie-1 and Tie-2 and Ang-1, 2 and 4 expression profile in human colorectal adenocarcinomas. |
15742397 |
Human |
tie-2 |
carcinoma |
RESULTS: Among the 96 cases of adenocarcinoma, 87 (90.6%), 92 (95.8%), 83 (86.5%), 89 (92.7%), and 76 cases (79.2%) showed positive staining in the cytoplasm of carcinoma cells for the Tie-1 and Tie-2 and Ang-1, 2 and 4 proteins, respectively. |
15742397 |
Human |
tie-2 |
tumor |
Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo. |
15928093 |
Human |
tie-2 |
tumor angiogenesis |
The endothelial cell receptor-tyrosine kinases, VEGF receptor 2 (VEGF-R2) and Tie-2, and their ligands, vascular endothelial growth factor (VEGF) and angiopoietins 1 and 2, respectively, play key roles in tumor angiogenesis. |
15928093 |
Human |
tie-2 |
tumor |
Several studies suggest that the VEGF receptor pathway and the Tie-2 pathway are independent and essential mediators of angiogenesis, leading to the hypothesis that simultaneous interference with both pathways should result in additive effects on tumor gr |
15928093 |
Human |
tie-2 |
tumor angiogenesis |
In this study, a human melanoma xenograft model (M21) was used to analyze the effects of simultaneous intradiabody depletion of vascular endothelial growth receptor-R2 and Tie-2 on tumor angiogenesis and tumor xenograft growth. |
15928093 |
Human |
tie-2 |
tumor |
In this study, a human melanoma xenograft model (M21) was used to analyze the effects of simultaneous intradiabody depletion of vascular endothelial growth receptor-R2 and Tie-2 on tumor angiogenesis and tumor xenograft growth. |
15928093 |
Human |
tie-2 |
melanoma |
In this study, a human melanoma xenograft model (M21) was used to analyze the effects of simultaneous intradiabody depletion of vascular endothelial growth receptor-R2 and Tie-2 on tumor angiogenesis and tumor xenograft growth. |
15928093 |
Human |
tie-2 |
tumor angiogenesis |
Blockade of both VEGF-R2 and Tie-2 pathways simultaneously or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis (92.2% and 74.4%, respectively). |
15928093 |
Human |
tie-2 |
tumor |
Blockade of both VEGF-R2 and Tie-2 pathways simultaneously or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis (92.2% and 74.4%, respectively). |
15928093 |
Human |
tie-2 |
tumor |
Previous studies with intrabodies had demonstrated that the Tie-2 receptor pathway was essential for tumor growth. |
15928093 |
Human |
tie-2 |
tumor |
The simultaneous blockade of the VEGF and Tie-2 pathways resulted in effective inhibition of tumor growth and demonstrated the potential of simultaneous targeting of multiple pathways as a therapeutic strategy. |
15928093 |
Human |
tie-2 |
tumors |
Tie-2 receptor has been shown to play a role in the neovascularization of tumors, but little is known about the role it may play in acute myocardial infarction (AMI). |
16037627 |
Human |
tie2 |
breast tumour |
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. |
9459145 |
Human |
tie2 |
breast tumours |
In this study, immunohistochemistry was used to evaluate the expression of a novel endothelial receptor tyrosine kinase, Tie2/Tek, in the endothelium of vascular 'hotspots' in normal breast tissue (n = 10), benign breast lesions (n = 10) and in |
9459145 |
Human |
tie2 |
breast tumours |
Moreover, the proportion of Tie2-positive vessels (Tie2 counts/CD31 counts) was significantly higher in breast tumours than the proportion of Tie2-positive vessels in either normal breast tissue or benign breast lesions (P = 0.004 and 0.0001 respectively) |
9459145 |
Human |
tie2 |
gliomas |
To assess the potential role of Tie2 and its ligands angiopoietin-1 and angiopoietin-2 in tumor vascularization, we analyzed their expression pattern in human gliomas. |
9811337 |
Human |
tie2 |
ks |
In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS, we studied the expression of angiopoietin-1, angiopoietin-2, angiopoietin-4, Tie1, and Tie2 mRNAs in biopsies of KS from 12 AIDS |
10854238 |
Human |
tie2 |
angiosarcomas |
Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. |
10854238 |
Human |
tie2 |
ks |
Strong expression of angiopoietin-2, Tie1, and Tie2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas, in contrast to the focal low-level expression in normal skin biopsies. |
10854238 |
Human |
tie2 |
nsclc |
We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal l |
10880843 |
Human |
tie2 |
glioblastomas |
Serial sections of 32 human glioma tissues (14 glioblastomas, eight anaplastic astrocytomas, seven astrocytomas, and three pilocytic astrocytomas) were immunostained against Ang2, vascular endothelial growth factor, Tie2, von Willebrand factor, and alpha |
11507079 |
Human |
tie2 |
pilocytic astrocytomas |
Serial sections of 32 human glioma tissues (14 glioblastomas, eight anaplastic astrocytomas, seven astrocytomas, and three pilocytic astrocytomas) were immunostained against Ang2, vascular endothelial growth factor, Tie2, von Willebrand factor, and alpha |
11507079 |
Human |
tie2 |
anaplastic astrocytomas |
Serial sections of 32 human glioma tissues (14 glioblastomas, eight anaplastic astrocytomas, seven astrocytomas, and three pilocytic astrocytomas) were immunostained against Ang2, vascular endothelial growth factor, Tie2, von Willebrand factor, and alpha |
11507079 |
Human |
tie2 |
astrocytomas |
Serial sections of 32 human glioma tissues (14 glioblastomas, eight anaplastic astrocytomas, seven astrocytomas, and three pilocytic astrocytomas) were immunostained against Ang2, vascular endothelial growth factor, Tie2, von Willebrand factor, and alpha |
11507079 |
Human |
tie2 |
astrocytomas |
In this review we summarize what is known of the biological role of Angiopoietins and Tie2, their interaction with VEGF in normal and tumor related angiogenesis, with emphasis on their functional consequence in the progression and growth of malignant huma |
12456344 |
Human |
tie2 |
bladder tumor |
Tumor growth was significantly inhibited in mice immunized against VEGF, VEGFR-2, and Tie2, either before tumor challenge or in the setting of pre-existing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models. |
12689940 |
Mouse |
tie2 |
astrocytomas |
Targeting the Tie2/Tek receptor in astrocytomas. |
14742253 |
Human |
tie2 |
brain tumor |
We investigated the role of Tie2 activation in malignant astrocytomas, a common and highly vascularized primary human brain tumor. |
14742253 |
Human |
tie2 |
astrocytomas |
We found that Tie2 expression and activation increases with increasing malignancy grade of astrocytomas. |
14742253 |
Human |
tie2 |
malignancy |
We found that Tie2 expression and activation increases with increasing malignancy grade of astrocytomas. |
14742253 |
Human |
tie2 |
subcutaneous tumor |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Human |
tie2 |
metastases |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Human |
tie2 |
venous malformation |
Based on a cohort of patients with a mutation in the TIE2 or glomulin gene or a histologic diagnosis, we defined clinical criteria for inherited GVM and cutaneomucosal venous malformation. |
15313813 |
Human |
tie2 |
tumour |
Tie2, an endothelial cell-specific receptor kinase, has an important role in tumour angiogenesis. |
14978510 |
Human |
tie2 |
aml |
In this study, we examined if the Angs-Tie2 autocrine pathway works in primary AML cells or not by using soluble Tie2-Fc, which inhibits Angs from binding to Tie2 receptor. |
15297853 |
Human |
tie2 |
tumors |
We previously reported that overexpression of Ang1 in MCF7 xenograft tumors facilitated vessel stabilization by mural cells, and that cultured SMC express Tie2. |
15501241 |
Mouse |
tie2 |
angiosarcomas |
Murine endothelial cells (ECs) overexpressing this G833DTie2 receptor exhibited an increase in cell proliferation at low serum concentrations and angiosarcomas developed in nude mice, whereas cells overexpressing either wild-type Tie2 or Q837HTie2 failed |
15377998 |
Mouse |
tie2 |
cancer |
This review discusses the regulation of Tie2 and its angiopoietin ligand family in inflammation-associated angiogenesis focusing on cancer, arthritis, and atherosclerosis. |
15569607 |
Human |
tie2 |
tumor |
Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. |
15653332 |
Human |
tie2 |
venous malformations |
We did not detect any mutations in the two loci of the TIE2 gene that have been reported in familial venous malformations. |
15672715 |
Human |
tie2 |
aml |
PATIENTS AND METHODS: We investigated the expression of VEGF-A, VEGF-C, angiopoietin-1 (Ang1), angiopoietin-2 (Ang2), and the receptor Tie2 by quantitative polymerase chain reaction in a cohort of 90 patients younger than 61 years with de novo AML entered |
15718307 |
Human |
tie2 |
breast carcinoma |
Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma. |
15753992 |
Human |
tie2 |
breast carcinoma |
The aim of this study was to investigate the prognostic value of vascular endothelial growth factor (VEGF) receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1), and Tie2/tek receptor tyrosine kinase in breast carcinoma. |
15753992 |
Human |
tie2 |
tumor |
In contrast Tie2 positive tumor surface (cutoff = 7%) was significantly correlated with poor overall survival (p=0.025) and also with high metastasis risk particularly among node negative patients (p<0.01). |
15753992 |
Human |
tie2 |
metastasis |
In contrast Tie2 positive tumor surface (cutoff = 7%) was significantly correlated with poor overall survival (p=0.025) and also with high metastasis risk particularly among node negative patients (p<0.01). |
15753992 |
Human |
tie2 |
metastasis |
Our results suggest that VEGFR-1 and Tie2 immunohistochemical expression permits the identification of patients with poor outcome, and particularly node negative ones with a high risk for metastasis and relapse. |
15753992 |
Human |
tie2 |
venous malformations |
Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations. |
15526080 |
Human |
tie2 |
venous malformation |
A missense mutation resulting in an R to W substitution in the kinase domain of Tie2 co-segregates with an autosomal dominantly inherited form of vascular dysmorphogenesis, venous malformation (VM). |
15526080 |
Human |
tie2 |
tumor |
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. |
16169466 |
Mouse |
tie2 |
tumors |
Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited to spontaneous and orthotopic tumors, (3) promote angiogenes |
16169466 |
Mouse |
tie2 |
tumor |
Besides TEMs and endothelial cells (ECs), Tie2 expression distinguished a rare population of tumor stroma-derived mesenchymal progenitors representing a primary source of tumor pericytes. |
16169466 |
Mouse |
tie2 |
tumor |
Therefore, Tie2 expression characterizes three distinct cell types required for tumor neovascularization: ECs, proangiogenic cells of hematopoietic origin, and pericyte precursors of mesenchymal origin. |
16169466 |
Mouse |
tie-2 |
breast cancer |
We hypothesised altered plasma Ang-1, Ang-2, Flt-1 and Tie-2 in breast cancer that would normalize after 3 and 12 months treatment (i.e., surgery plus chemo/radiotherapy). |
16891056 |
Human |
tie-2 |
breast cancer |
RESULTS: Women with breast cancer had raised VEGF (7-fold), Ang-1 (50% higher) and Tie-2 (2-fold), but lower Flt-1 (to 26%), compared to the BBD women that broadly correlated with markers of platelet activation and inflammation. |
16891056 |
Human |
tie-2 |
breast cancer |
A level of Tie-2 or VEGF >95th percentile of the BBD group correctly identified 68% and 52% of the women with breast cancer. |
16891056 |
Human |
tie-2 |
breast cancer |
CONCLUSIONS: Treatment for breast cancer (surgery followed by chemotherapy and/or radiotherapy) is effective in reducing plasma VEGF, Tie-2 and Ang-1. |
16891056 |
Human |
tie-2 |
tumor |
The receptors tissue factor (TF), alpha V beta 3 integrin and Tie-2 were expressed on the vascular endothelium in the periphery but not in the center of the tumor spheroids nor in the mammary tissue nor in smooth muscle tissue, whereas Tie-1 and PCAM-1 we |
17235351 |
Human |
tie-2 |
tumor angiogenesis |
However, the significance of Tie-2 signaling in tumor angiogenesis is not well understood. |
17253678 |
Human |
tie-2 |
tumor angiogenesis |
In order to evaluate the therapeutic utility of inhibiting Tie-2 signaling, we developed a series of potent and orally bioavailable small molecule Tie-2 kinase inhibitors with selectivity over other kinases, especially those that are believed to be import |
17253678 |
Human |
tie-2 |
tumor |
Interference with the Tie-2 pathway by diverse blocking agents such as soluble Tie-2 receptors, anti-Tie-2 intrabodies, anti-Ang-2 antibodies, and peptide-Fc conjugates has been shown to suppress tumor growth in xenograft studies. |
17253679 |
Human |
tie-2 |
cancer |
During our effort to develop dual VEGFR2 and Tie-2 inhibitors as anti-angiogenic agents for cancer therapy, we discovered 4-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)- aminocarbonylamino)phenyl)furo[2,3-d]pyrimidine (8a) possessing strong inhibitory |
17276055 |
Human |
tie2 |
endometrial adenocarcinoma |
Immunohistochemical staining for vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1, Ang2, Tie2, CD34 and CD105 was performed on formalin-fixed and paraffin-embedded tissues from 31 normal endometrium and 85 endometrial adenocarcinoma. |
17295646 |
Human |
tie2 |
tumor |
VEGF, Ang1, Ang2 and Tie2 expression was localized in the cytoplasm of glandular and tumor cells. |
17295646 |
Human |
tie2 |
adenocarcinoma |
In general, VEGF and Tie2 expression was higher in adenocarcinoma than in normal epithelial cells. |
17295646 |
Human |
tie2 |
ibd |
Epithelial repair in experimental IBD was mediated either by induction of improved vasculogenesis or by the differentiation of the transplanted stem cells into endothelial cells, as demonstrated by the promotion of Tie2 activity in the infused cells at th |
17383423 |
Mouse |
vmcm1 |
venous malformation |
Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type |
11932989 |
Human |
tie-2 |
megakaryoblastic leukaemia |
The erythroblastic/megakaryoblastic leukaemia cell lines also expressed the related Tie-2/Tek gene and, surprisingly, its recently cloned ligand gene angiopoietin-1, which was located in chromosome 8q23.1. |
9233584 |
Human |
tie-2 |
colon cancer |
Mouse syngeneic colon cancer cells (MCA38) were implanted subcutaneously into Flk-1/LZ/BMT (bone marrow transplantation) and Tie-2/LZ/BMT mice; tumor samples harvested at 1 week disclosed abundant flk-1/lacZ and tie-2/lacZ fusion transcripts, and sections |
10436164 |
Mouse |
tie-2 |
tumor |
Mouse syngeneic colon cancer cells (MCA38) were implanted subcutaneously into Flk-1/LZ/BMT (bone marrow transplantation) and Tie-2/LZ/BMT mice; tumor samples harvested at 1 week disclosed abundant flk-1/lacZ and tie-2/lacZ fusion transcripts, and sections |
10436164 |
Mouse |
tie-2 |
tumor |
Six sets of double immunohistochemical stainings for Tie-1/Tie-2 and fibronectin, CD68, or CD34 were carried out to determine the phenotype of Tie-1 and Tie-2-positive tumor components. |
11261813 |
Human |
tie-2 |
melanoma |
When human melanoma cells A375 are stably transfected to produce the soluble variant of the angiopoietin receptor TIE-2 (sTIE-2), they show a substantial inhibition of tumor growth on nude mice. |
11441305 |
Human |
tie-2 |
tumor |
When human melanoma cells A375 are stably transfected to produce the soluble variant of the angiopoietin receptor TIE-2 (sTIE-2), they show a substantial inhibition of tumor growth on nude mice. |
11441305 |
Human |
tie-2 |
tumor angiogenesis |
These experiments show that the inhibition of the angiopoietin/TIE-2 system, similar to the inhibition of the VEGF/VEGF receptor system, has an antitumoral effect, most probably due to the inhibition of tumor angiogenesis. |
11441305 |
Human |
tie-2 |
tumor |
Our study suggests a novel mechanism by which tumor-derived VEGF interacts with Angs/Tie-2 system in host stroma endothelial cells and induces in a paracrine manner the remodeling of host vasculature to support angiogenesis during tumor growth. |
12810677 |
Human |
tie-2 |
breast carcinomas |
Long-term prognostic significance of neoangiogenesis in breast carcinomas: comparison of Tie-2/Tek, CD105, and CD31 immunocytochemical expression. |
14991534 |
Human |
tie-2 |
breast carcinomas |
The immunocytochemical detection of Tie-2/Tek, CD105, and CD31 was assessed in a large series (n = 905) of breast carcinomas on frozen sections. |
14991534 |
Human |
tie-2 |
metastases |
Marked expression of CD31 (P = 0.024), CD105 (P = 0.001), and Tie-2/Tek (P = 0.01) also correlated with higher risk of metastases in node-negative patients. |
14991534 |
Human |
tie-2 |
breast carcinomas |
It is concluded that CD105 immunoexpression in breast carcinomas is an independent prognostic indicator in node-negative patients, better in terms of overall survival than Tie-2/Tek and CD31. |
14991534 |
Human |
tie-2 |
metastases |
CONCLUSIONS: In patients with SCCOC, plasma levels of VEGF and serum levels of FLT-1 and Tie-2 do not provide any further information on the biological tumor behavior like proliferation or expression of metastases. |
15007517 |
Human |
tie-2 |
tumor |
CONCLUSIONS: In patients with SCCOC, plasma levels of VEGF and serum levels of FLT-1 and Tie-2 do not provide any further information on the biological tumor behavior like proliferation or expression of metastases. |
15007517 |
Human |
tie-2 |
breast cancer |
Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). |
15026804 |
Human |
tie-2 |
metastasis |
Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). |
15026804 |
Human |
tie-2 |
breast carcinoma |
Our purpose was to document the prognostic significance of VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 immunoexpression in breast carcinoma frozen samples (n=905, follow-up=11.7 years). |
15026804 |
Human |
tie-2 |
renal carcinoma |
These results suggest that the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. |
15198927 |
Human |
tie-2 |
tumor angiogenesis |
These results suggest that the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. |
15198927 |
Human |
tie-2 |
human colon carcinoma |
To explore the therapeutic potential of blocking Tie-2 receptor-interaction pathway, an adenoviral vector was used to deliver a recombinant single-chain antibody fragment rabbit intrabody (pAd-2S03) capable of inhibition of both mouse and human Tie-2 surf |
15705898 |
Human |
tie-2 |
kaposi's sarcoma |
To explore the therapeutic potential of blocking Tie-2 receptor-interaction pathway, an adenoviral vector was used to deliver a recombinant single-chain antibody fragment rabbit intrabody (pAd-2S03) capable of inhibition of both mouse and human Tie-2 surf |
15705898 |
Human |
tie-2 |
colon carcinoma |
Our results show that the Tie-2 receptor pathway is essential for both SLK sarcoma and SW1222 colon carcinoma xenograft growth. |
15705898 |
Mouse |
tie-2 |
sarcoma |
Our results show that the Tie-2 receptor pathway is essential for both SLK sarcoma and SW1222 colon carcinoma xenograft growth. |
15705898 |
Mouse |
tie-2 |
retinoblastoma |
Experimental retinoblastoma was studied by immunohistochemistry staining for the expression of angiogenesis factors (VEGF-A, VEGF-C, VEGF-D and bFGF), vascular endothelial cell membrane receptor tyrosine kinases (Flt-1, Flt-4, Flk-1, Tie-2 and FGFR), tran |
15938806 |
Human |
tie-2 |
tumour |
A potential target for a cancer vaccine would be receptors, such as Tie-2 which are over expressed on tumour endothelium. |
16408213 |
Human |
tie-2 |
tumor angiogenesis |
Angiopoietin (Ang) is a ligand for the endothelium-specific tyrosine kinase receptor Tie-2, while a shift in the Ang-1:Ang-2 expression ratio in favor of Ang-2 was found to be associated with tumor angiogenesis. |
16538528 |
Human |
tek |
megakaryoblastic leukaemia |
The erythroblastic/megakaryoblastic leukaemia cell lines also expressed the related Tie-2/Tek gene and, surprisingly, its recently cloned ligand gene angiopoietin-1, which was located in chromosome 8q23.1. |
9233584 |
Human |
tek |
acute myeloid leukemia (aml) |
The expression of both the TEK receptor and its ligand in acute myeloid leukemia (AML) and CML patients might, therefore, suggest an involvement of these genes in the pathogenesis of myeloproliferative disorders. |
11755466 |
Human |
tek |
cml |
The expression of both the TEK receptor and its ligand in acute myeloid leukemia (AML) and CML patients might, therefore, suggest an involvement of these genes in the pathogenesis of myeloproliferative disorders. |
11755466 |
Human |
tek |
breast carcinoma |
Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients. |
12527939 |
Human |
tek |
breast cancer |
Tie2/tek receptor tyrosine kinase is a novel marker of microvasculature of solid tumors that appears to play a key role in the angiogenesis process in breast cancer. |
12527939 |
Human |
tek |
breast carcinomas |
Long-term prognostic significance of neoangiogenesis in breast carcinomas: comparison of Tie-2/Tek, CD105, and CD31 immunocytochemical expression. |
14991534 |
Human |
tek |
breast carcinomas |
The immunocytochemical detection of Tie-2/Tek, CD105, and CD31 was assessed in a large series (n = 905) of breast carcinomas on frozen sections. |
14991534 |
Human |
tek |
metastases |
Marked expression of CD31 (P = 0.024), CD105 (P = 0.001), and Tie-2/Tek (P = 0.01) also correlated with higher risk of metastases in node-negative patients. |
14991534 |
Human |
tek |
breast carcinomas |
It is concluded that CD105 immunoexpression in breast carcinomas is an independent prognostic indicator in node-negative patients, better in terms of overall survival than Tie-2/Tek and CD31. |
14991534 |
Human |
tek |
breast cancer |
Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). |
15026804 |
Human |
tek |
metastasis |
Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905). |
15026804 |
Human |
tek |
breast carcinoma |
Our purpose was to document the prognostic significance of VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 immunoexpression in breast carcinoma frozen samples (n=905, follow-up=11.7 years). |
15026804 |
Human |
tie2 |
nsclc |
The findings suggested a role of the Ang-1/Tie2 pathway in the maintenance of the complex vasculature in normal lung, while collaborative activities between the Ang-2 and VEGF pathways might be important in promoting tumour angiogenesis in NSCLC. |
10880843 |
Human |
tie2 |
tumour |
The findings suggested a role of the Ang-1/Tie2 pathway in the maintenance of the complex vasculature in normal lung, while collaborative activities between the Ang-2 and VEGF pathways might be important in promoting tumour angiogenesis in NSCLC. |
10880843 |
Human |
tie2 |
hemangioma |
KDR, Flt-1, Tie1, Tie2, and angiopoietin-2 (Ang2) were strongly expressed in cultured hemangioma-derived endothelial cells and in hemangioma tissue. |
11733376 |
Human |
tie2 |
hemangioma |
These findings implicate Tie2 and its ligands Ang1 and Ang2 in the pathogenesis of hemangioma. |
11733376 |
Human |
tie2 |
venous malformation |
Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type |
11932989 |
Human |
tie2 |
squamous cell carcinoma |
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. |
11943723 |
Human |
tie2 |
clear cell carcinomas |
No significant relationships were observed in clear cell carcinomas between Ang-1, Ang-2 and Tie2 mRNA abundance and patient sex, patient age, or tumour size (p > 0.05). |
12434420 |
Human |
tie2 |
breast carcinoma |
Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients. |
12527939 |
Human |
tie2 |
breast cancer |
Tie2/tek receptor tyrosine kinase is a novel marker of microvasculature of solid tumors that appears to play a key role in the angiogenesis process in breast cancer. |
12527939 |
Human |
tie2 |
hepatocellular carcinoma (hcc) |
To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology of hepatocellular carcinoma (HCC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HCC, 8 cirrhotic and 8 |
12539584 |
Human |
tie2 |
hepatic cancer |
It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation, promoting the development and metastasis |
12539584 |
Human |
tie2 |
metastasis |
It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation, promoting the development and metastasis |
12539584 |
Human |
tie2 |
hepatocellular carcinoma (hcc) |
OBJECTIVE: To explore the effect of two dominating signaling pathways, VEGF/KDR and angiopoietins/Tie2, on the formation of new blood vessel in hepatocellular carcinoma (HCC) growth and metastasis. |
14627514 |
Human |
tie2 |
tumor |
Immunohistochemistry, electron microscopy, expression analyses, and in situ hybridization provide evidence that this resistance of tumor blood vessels to VEGFR-2 targeting is conferred by pericytes that stabilize blood vessels and provide endothelial cell |
14657001 |
Human |
tie2 |
tumor |
Expression and long-term follow-up of VEGF, FLT-1 and Tie2 in serum] OBJECTIVE: The quantification of serum or plasma levels of angiogenic factors in patients with malignancies aims at the description of these factors or their receptors and allows a tissu |
15007517 |
Human |
tie2 |
squamous cell carcinoma of the oral cavity |
METHODS: In 51 patients with untreated squamous cell carcinoma of the oral cavity (SCCOC) and 10 healthy controls, plasma levels of VEGF and serum levels of the VEGF-receptor FLT-1 and the Ang1-receptor Tie2 were measured. |
15007517 |
Human |
tie2 |
hepatocellular carcinoma |
METHODS: Expression of VEGF/KDR and Angiopoietins/Tie2 was detected by RT-PCR and Western blot in 15 cases with hepatocellular carcinoma, 15 tumor adjacent tissues (<1 cm, >5 cm), 8 cirrhotic liver, and 4 normal liver. |
15555336 |
Human |
tie2 |
tumor |
METHODS: Expression of VEGF/KDR and Angiopoietins/Tie2 was detected by RT-PCR and Western blot in 15 cases with hepatocellular carcinoma, 15 tumor adjacent tissues (<1 cm, >5 cm), 8 cirrhotic liver, and 4 normal liver. |
15555336 |
Human |
tie2 |
tumor |
The expressions of KDR and Ang1/Tie2 showed no significant difference in all groups, but they indeed increased to various levels in tumor and tumor adjacent tissues as compared with those in cirrhosis and normal liver. |
15555336 |
Human |
tie2 |
hepatocellular carcinoma |
CONCLUSION: VEGF/KDR and Angiopoietins/Tie2 may be the crucial signal pathways in the development of hepatocellular carcinoma. |
15555336 |
Human |
tie2 |
human gastric cancer |
Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer. |
16185665 |
Human |
tie2 |
gastric cancer |
In addition, Ang-2 as well as its receptor Tie2 expressions were higher in 12 pairs of gastric cancer tissue samples than those in corresponding adjacent samples by Western blot, while Ang-1 expression showed great heterogeneity. |
16185665 |
Human |
tie2 |
tumor angiogenesis |
Angiopoietin-1, 2 and Tie2 expressions in endometrial adenocarcinoma--the Ang2 dominant balance up-regulates tumor angiogenesis in the presence of VEGF. |
16620053 |
Human |
tie2 |
endometrial adenocarcinoma |
We investigated Ang1, Ang2 and Tie2 expressions including balance and intratumoral vessels in the role of angiogenesis of endometrial adenocarcinoma. |
16620053 |
Human |
tie2 |
tumor |
Ang1, Ang2, Tie2 and CD34 were expressed in the cytoplasm of tumor cells. |
16620053 |
Human |
tie2 |
hepatocellular carcinoma |
Expression of angiopoietins, Tie2 and vascular endothelial growth factor in angiogenesis and progression of hepatocellular carcinoma. |
16830384 |
Human |
tie2 |
hepatocellular carcinoma (hcc) |
AIM: To investigate the significance of angiopoietins, Tie2 and vascular endothelial growth factor (VEGF) expression in the angiogenesis and progress of hepatocellular carcinoma (HCC). |
16830384 |
Human |
tie2 |
hepatocellular carcinoma |
CONCLUSION: Dominant Ang-2 expression against Ang-1 through Tie2 receptor in the presence of VEGF plays a critical role in initiating early neovascularization and transformation of noncancerous liver to hepatocellular carcinoma. |
16830384 |
Human |
tie2 |
hepatocellular carcinoma |
The expressions of Ang2 and Tie2 positively correlated with microvessal density in hepatocellular carcinoma (P<0.05). |
16951510 |
Rat |
tie2 |
acute myeloid leukemia |
Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia. |
16956819 |
Human |
tie2 |
acute myeloid leukemia (aml) |
DESIGN AND METHODS: We investigated the expression of Ang-1, Ang-2 and Tie2 by immunohistochemical analyses in bone marrow biopsies of 64 adult patients with newly diagnosed acute myeloid leukemia (AML) and correlated angiogenic factor expression with cli |
16956819 |
Human |
tie-2 |
infiltrating carcinoma |
The cancer patients had significantly elevated Tie-2 expression with the highest levels associated with infiltrating carcinoma. |
12878859 |
Human |
tie2 |
human renal cell carcinomas |
To determine the significance and regulation of the angiopoietin (Ang) pathway in highly vascular human renal cell carcinomas (RCCs), this study has investigated the expression of the Ang-1, Ang-2, Ang-4, and Tie2 genes in a series of normal (n = 26) and |
12434420 |
NA |
tie2 |
hepatic carcinoma |
It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation, promoting the development and metastasis |
12539584 |
Human |
tie-2 |
melanoma |
In sarcoma/melanoma patients treated regionally with TNF and chemotherapy we observed a rise in VEGF-A, SCF, VEGFR-2, MMP-9, Tie-2 and CRP, a correlation between CRP and IL-8, and a decreased in sVEGFR-1 levels. |
16114015 |
Human |
tie-2 |
sarcoma |
In sarcoma/melanoma patients treated regionally with TNF and chemotherapy we observed a rise in VEGF-A, SCF, VEGFR-2, MMP-9, Tie-2 and CRP, a correlation between CRP and IL-8, and a decreased in sVEGFR-1 levels. |
16114015 |
Human |
tie-2 |
inflammatory bowel disease |
Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease. |
16436095 |
Human |
tie-2 |
crohn's disease |
The aim of the study was to evaluate the serum markers of angiogenesis angiopoietin-2 (Ang-2) and soluble angiopoietin receptor Tie-2 in patients with ulcerative colitis (UC) and Crohn's disease (CD). |
16436095 |
Human |
tie-2 |
ibd |
MATERIALS AND METHODS: Serum Ang-2 and Tie-2 serum levels were measured in 160 IBD patients (79 UC and 81 CD) and in 80 matched healthy controls using commercially available enzyme-linked immunosorbent assays. |
16436095 |
Human |
tie-2 |
ibd |
The IBD patients with early disease (diagnosis < 2 years) had significantly higher (P = 0.04) median serum Ang-2 levels but significantly lower (P = 0.02) median serum Tie-2 levels as compared with IBD patients with late disease (diagnosis > 2 years). |
16436095 |
Human |
tie-2 |
tumors |
Immunotherapy of tumors with protein vaccine based on chicken homologous tie-2. |
16551866 |
Human |
tie-2 |
tumor angiogenesis |
PURPOSE: Tie-2 is an endothelium-specific receptor tyrosine kinase known to play a key role in tumor angiogenesis. |
16551866 |
Human |
tie-2 |
tumors |
The present study explores the feasibility of immunotherapy of tumors by using a protein vaccine based on chicken Tie-2 as a model antigen to break the immune tolerance against Tie-2 in a cross-reaction between the xenogeneic homologous and self-Tie-2. |
16551866 |
Human |
tie-2 |
hepatoma |
Experimental Design and RESULTS: In this study, a chicken homologous Tie-2 protein vaccine (chTie-2) and a corresponding mouse Tie-2 vaccine as a control were prepared and the antitumor effect of these vaccines was tested in two tumor models (murine B16F1 |
16551866 |
Human |
tie-2 |
melanoma |
Experimental Design and RESULTS: In this study, a chicken homologous Tie-2 protein vaccine (chTie-2) and a corresponding mouse Tie-2 vaccine as a control were prepared and the antitumor effect of these vaccines was tested in two tumor models (murine B16F1 |
16551866 |
Human |
tie-2 |
tumor |
Experimental Design and RESULTS: In this study, a chicken homologous Tie-2 protein vaccine (chTie-2) and a corresponding mouse Tie-2 vaccine as a control were prepared and the antitumor effect of these vaccines was tested in two tumor models (murine B16F1 |
16551866 |
Human |
tie-2 |
cancer |
CONCLUSIONS: Our findings may provide a vaccine strategy for cancer therapy and show the potential utilization of interference with Tie-2 pathway. |
16551866 |
Human |
tie-2 |
tumor |
We also identified a new autocrine/paracrine stimulatory loop between the receptor Tie-2 and the hypoxia-inducible factor target Ang-1, which, combined with previous observations, suggests that a variety of autocrine loops may be initiated in hemangioblas |
16618738 |
Human |
tie-2 |
gastric cancers |
[Correlation between the expression of angiopoietins and their receptor and angiogenesis in gastric cancers] OBJECTIVE: To explore the effects of angiopoietins (Ang-1 and Ang-2) and Tie-2 expression on microvessel density (MVD) in gastric cancers. |
16875629 |
Human |
tie-2 |
primary gastric cancers |
METHODS: By using semiquantitative RT-PCR, immunohistochemistry and image analysis system, the expression of Ang-1, Ang-2, Tie-2 mRNA and their proteins were detected in 68 primary gastric cancers and their adjacent normal tissues. |
16875629 |
Human |
tie-2 |
gastric cancers |
RESULTS: The expression of all Ang-1, Ang -2, Tie-2 mRNA and their proteins was detected in gastric cancers and their paired adjacent gastric mucosa tissues. |
16875629 |
Human |
tie-2 |
gastric cancers |
A negative correlation between Ang-1 protein, Tie-2 mRNA and MVD in gastric cancers was observed (r = -0.440, r = -0.267; P < 0.05), while the relation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio with MVD were positive (r = 0.319, r = 0. |
16875629 |
Human |
tie-2 |
gastric cancers |
CONCLUSION: Ang-1 activates Tie-2 receptor, whereas Ang-2 antagonizes Ang-1 in the angiogenesis, and the Ang-2/Ang-1 ratio determines angiogenesis and tumor growth in gastric cancers. |
16875629 |
Human |
tie-2 |
tumor |
CONCLUSION: Ang-1 activates Tie-2 receptor, whereas Ang-2 antagonizes Ang-1 in the angiogenesis, and the Ang-2/Ang-1 ratio determines angiogenesis and tumor growth in gastric cancers. |
16875629 |
Human |
tek |
tumor |
To evaluate the expression of the Tie2/Tek tyrosine kinase receptor in tumor blood vessels, we examined Tie2lacZ(+)/RAG1(-) mice. |
16314485 |
Human |
tek |
tumor |
High expression of angiopoietins and TEK is often detected in tumor tissues. |
16456789 |
Human |
tek |
human tumors |
Many studies showed that disrupting the ANGPT/TEK receptor pathway could inhibit the growth of a number of murine tumors and human tumors. |
16456789 |
Human |
tek |
tumors |
Many studies showed that disrupting the ANGPT/TEK receptor pathway could inhibit the growth of a number of murine tumors and human tumors. |
16456789 |
Human |
tek |
cancer |
Thus, it is possible that inhibitors targeting the ANGPT/TEK pathway will have broad clinical utility to treatment of cancer. |
16456789 |
Human |
tie2 |
tumor angiogenesis |
Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases. |
15569607 |
Human |
tie2 |
prostate tumor |
Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model. |
16169279 |
Human |
tie2 |
tumor |
Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model. |
16169279 |
Human |
tie2 |
colon carcinoma |
To address this issue, CT26 murine colon carcinoma cells were transfected with retroviral vectors encoding murine endostatin (mEndostatin), human angiostatin (hAngiostatin), murine-soluble vascular endothelial growth factor receptor-2, (msFlk-1), or murin |
16242720 |
Mouse |
tie2 |
cancer |
Heterogeneity of tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. |
16314485 |
Mouse |
tie2 |
tumor |
Heterogeneity of tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. |
16314485 |
Mouse |
tie2 |
tumor |
To evaluate the expression of the Tie2/Tek tyrosine kinase receptor in tumor blood vessels, we examined Tie2lacZ(+)/RAG1(-) mice. |
16314485 |
Human |
tie2 |
metastases |
Similar patterns of Tie2 expression occurred in abdominal metastases derived from the same cell lines. |
16314485 |
Human |
tie2 |
cancers |
Similar Tie2 heterogeneity was observed in clinical specimens from a variety of human cancers, including malignant melanoma and colorectal carcinoma. |
16314485 |
Human |
tie2 |
colorectal carcinoma |
Similar Tie2 heterogeneity was observed in clinical specimens from a variety of human cancers, including malignant melanoma and colorectal carcinoma. |
16314485 |
Human |
tie2 |
malignant melanoma |
Similar Tie2 heterogeneity was observed in clinical specimens from a variety of human cancers, including malignant melanoma and colorectal carcinoma. |
16314485 |
Human |
tie2 |
tumor |
We also examined the effect of Tek-Delta Fc anti-angiogenic therapy on tumor growth and Tie2 expression patterns in HCT116 and WM115 subcutaneous xenografts. |
16314485 |
Human |
tie2 |
cancer |
Thus, vascular heterogeneity of Tie2 expression is cancer-type specific, suggesting that the tumor microenvironment and/or direct cancer cell interactions influence Tie2 endothelial expression. |
16314485 |
Human |
tie2 |
tumor |
Thus, vascular heterogeneity of Tie2 expression is cancer-type specific, suggesting that the tumor microenvironment and/or direct cancer cell interactions influence Tie2 endothelial expression. |
16314485 |
Human |
tie2 |
tumor |
We have determined that ELF-1 and Tie2 expression is also enriched in tumor blood vessels, and have identified a short peptide, 34 amino acids in length, corresponding to the terminal portion of the highly conserved ETS domain that potently blocks the fun |
16352813 |
Mouse |
tie2 |
tumor angiogenesis |
These results support the function of ELF-1 in the regulation of Tie2 gene expression during the development of tumor angiogenesis. |
16352813 |
Mouse |
tie2 |
venous malformations |
These genes include AGGF1 for Klippel-Trenaunay syndrome, RASA1 for capillary malformations, KRIT1, MGC4607, PDCD10 for cerebral cavernous malformations, glomulin for glomuvenous malformations, TIE2 for multiple cutaneous and mucosal venous malformations, |
16379592 |
Human |
tie2 |
tumor |
In parallel, EphB4 reduces the permeability of the tumor vascular system via activation of the angiopoietin-1/Tie2 system at the endothelium/pericyte interface. |
16424904 |
Mouse |
tie2 |
cancers |
Tie2 expression is also upregulated in various cancers implicating a role in tumor angiogenesis. |
16457819 |
Human |
tie2 |
tumor angiogenesis |
Tie2 expression is also upregulated in various cancers implicating a role in tumor angiogenesis. |
16457819 |
Human |
tie2 |
lymphangioma |
TIE2 Gain-of-Function Mutation in a Patient with Pancreatic Lymphangioma Associated with Blue Rubber-Bleb Nevus Syndrome: Report of a Case. |
16493543 |
Human |
tie2 |
nevus |
TIE2 Gain-of-Function Mutation in a Patient with Pancreatic Lymphangioma Associated with Blue Rubber-Bleb Nevus Syndrome: Report of a Case. |
16493543 |
Human |
tie2 |
human gastric carcinoma |
Expression of angiopoietin 1, 2 and their common receptor tie2 in human gastric carcinoma: implication for angiogenesis. |
16614513 |
Human |
tie2 |
tumor angiogenesis |
Angiopoietin 1 (Ang-1) and 2 (Ang-2) and their common receptor, Tie2, are thought to be critical regulators of tumor angiogenesis. |
16614513 |
Human |
tie2 |
gastric cancers |
We examined expression of Ang-1, Ang-2, and their common receptor Tie2 mRNAs and proteins in gastric cancers using in situ hybridization and immunohistochemistry. |
16614513 |
Human |
tie2 |
cancer |
The expression of Ang-1, Ang-2, and Tie2 mRNA in cancer cells significantly correlated with the MVD (p<0.001, <0.001 and =0.019, respectively). |
16614513 |
Human |
tie2 |
advanced gastric cancers |
Ang-1 and Tie2 positivity correlated with advanced gastric cancers (p<0.05) and larger cancers had higher positive rates of Ang-1, Ang-2, and Tie2 mRNA expression (p<0.001, =0.010 and =0.039, respectively). |
16614513 |
Human |
tie2 |
cancers |
Ang-1 and Tie2 positivity correlated with advanced gastric cancers (p<0.05) and larger cancers had higher positive rates of Ang-1, Ang-2, and Tie2 mRNA expression (p<0.001, =0.010 and =0.039, respectively). |
16614513 |
Human |
tie2 |
gastric cancer |
These findings indicate that the expression of Ang-1 and Ang-2 is important for tumor angiogenesis, and suggest a possible role of autocrine/paracrine function of angiopoietin/Tie2 system in gastric cancer progression. |
16614513 |
Human |
tie2 |
tumor angiogenesis |
These findings indicate that the expression of Ang-1 and Ang-2 is important for tumor angiogenesis, and suggest a possible role of autocrine/paracrine function of angiopoietin/Tie2 system in gastric cancer progression. |
16614513 |
Human |
tie2 |
venous malformation |
Mutant Tie2 causing venous malformation signals through Shc. |
16756945 |
Human |
tie2 |
venous malformation |
A missense mutation in the intracellular domain of Tie2 resulting in an arginine to tryptophan substitution causes an inherited form of vascular dysmorphogenesis, venous malformation (VM). |
16756945 |
Human |
tie-2 |
polycystic liver diseases |
In conclusion, consistent with the immature phenotype of the cystic epithelium, expression of VEGF, VEGFRs, Ang-1 and Tie-2 is strongly upregulated in cholangiocytes from polycystic liver diseases. |
16628643 |
Human |
tie-2 |
tumor |
Other experiments used Herceptin- or heregulin beta 1-pretreated MCF-7 cells to modulate HER2 signaling, or soluble Tie-2/Fc receptor fusion protein (sTie2) to sequester tumor-cell released Ang-2. |
11490375 |
Human |
tie-2 |
leukemia |
Although Ang-2 is recognized as a natural antagonist for Tie-2, our data presented here suggested the alternative role of Ang-2 in the relationship between endothelial cells and leukemia cells, at least in a subset of leukemia such as CD7(+)AML. |
11840270 |
Human |
tie-2 |
hepatocarcinogenesis |
These results indicate that c-Met, Tie-2 and Flk-1 signals play important roles in different stages of chemically-induced hepatocarcinogenesis. |
11956651 |
Rat |
tie-2 |
primary tumors |
EXPERIMENTAL DESIGN: We investigated immunohistochemically the expression patterns and levels of antiangiogenic factor and its receptor, thrombospondin-1 (TSP-1) and CD36, and four angiogenic factors, vascular endothelial growth factor (VEGF), VEGF-C, ang |
12006528 |
Human |
tie-2 |
hnscc |
BACKGROUND: This study assessed two circulating angiogenic receptors as tumor markers in patients with head and neck squamous cell carcinoma (HNSCC): soluble vascular endothelial factor growth receptor-1 (sVEGFR1) and soluble Tie-2 receptor (sTie2R). |
12203803 |
Human |
tie-2 |
hcc |
In this study, we investigated the expression of Ang-1, Ang-2, Tie-2, and vascular endothelial growth factor (VEGF) in surgically resected specimens from 46 patients with HCC to determine their potential role in tumor angiogenesis and its progression. |
12717391 |
Human |
tie-2 |
hcc |
On the other hand, Ang-1 and Tie-2 mRNA expression in HCC was not different from that in adjacent liver tissue. |
12717391 |
Human |
tie-2 |
tumors |
Three weeks later, sections from the tumors were stained for CD31 and examined for Tie-2-driven GFP expression. |
14757432 |
Human |
tie-2 |
hcc |
The expression of Angiopoietin-1, Angiopoietin-2, and their receptor Tie-2 in HCC was assessed by immunohistochemistry. |
15094228 |
Human |
tie-2 |
tumorigenesis |
CONCLUSIONS: Although Tie-2 and Ang-1 are not differentially expressed in pancreatic tumors, Ang-2 gene and gene product are overexpressed, suggesting a significant role for Ang-2 in pancreatic tumorigenesis. |
15501112 |
Human |
tie-2 |
primary tumors |
To explore the therapeutic potential of blocking Tie-2 receptor-interaction pathway, an adenoviral vector was used to deliver a recombinant single-chain antibody fragment rabbit intrabody (pAd-2S03) capable of inhibition of both mouse and human Tie-2 surf |
15705898 |
Human |
tie-2 |
tumor angiogenesis |
In contrast, human Tie-2-monospecific pAd-1S05 intrabody did not affect the growth of tumors, indicating that the antitumor effect of pAd-2S03 was due to the inhibition of tumor angiogenesis in these murine models. |
15705898 |
Human |
tie-2 |
tumors |
In contrast, human Tie-2-monospecific pAd-1S05 intrabody did not affect the growth of tumors, indicating that the antitumor effect of pAd-2S03 was due to the inhibition of tumor angiogenesis in these murine models. |
15705898 |
Human |
tie-2 |
neuroblastoma |
Angiopoietin-1 (Ang-1), an endothelial cell growth factor with influences on blood vessel stabilization, has been recently reported to prevent apoptosis in a neuroblastoma cell line via a pathway dependent on Tie-2 receptor. |
15714275 |
Human |
tie-2 |
adenocarcinoma |
RESULTS: Among the 96 cases of adenocarcinoma, 87 (90.6%), 92 (95.8%), 83 (86.5%), 89 (92.7%), and 76 cases (79.2%) showed positive staining in the cytoplasm of carcinoma cells for the Tie-1 and Tie-2 and Ang-1, 2 and 4 proteins, respectively. |
15742397 |
Human |
tie-2 |
tumor |
Several studies suggest that the VEGF receptor pathway and the Tie-2 pathway are independent and essential mediators of angiogenesis, leading to the hypothesis that simultaneous interference with both pathways should result in additive effects in tumor gr |
16688670 |
Human |
tie-2 |
tumor angiogenesis |
In a human melanoma xenograft mouse model, we could show that blockade of both VEGF-R2 and Tie-2 pathways or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis (92.2 % and 74.4 %). |
16688670 |
Human |
tie-2 |
melanoma |
In a human melanoma xenograft mouse model, we could show that blockade of both VEGF-R2 and Tie-2 pathways or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis (92.2 % and 74.4 %). |
16688670 |
Human |
tie-2 |
tumor |
In a human melanoma xenograft mouse model, we could show that blockade of both VEGF-R2 and Tie-2 pathways or the VEGF receptor pathway alone resulted in a significant inhibition of tumor growth and tumor angiogenesis (92.2 % and 74.4 %). |
16688670 |
Human |
tie-2 |
hemangioma |
Here, we demonstrate constitutive activation of the endothelial tie-2 receptor in human hemangioma of infancy and, using a murine model of hemangioma, bEnd.3 cells; we show that bEnd.3 hemangiomas produce both angiopoietin-2 (ang-2) and its receptor, tie- |
16741507 |
Human |
tie-2 |
hemangiomas |
Here, we demonstrate constitutive activation of the endothelial tie-2 receptor in human hemangioma of infancy and, using a murine model of hemangioma, bEnd.3 cells; we show that bEnd.3 hemangiomas produce both angiopoietin-2 (ang-2) and its receptor, tie- |
16741507 |
Human |
tie-2 |
hemangioma |
We also demonstrate that inhibition of tie-2 signaling with a soluble tie-2 receptor decreases bEnd.3 hemangioma growth in vivo. |
16741507 |
Human |
tie-2 |
hemangioma |
To address this issue, we used tie-2-deficient bEnd.3 hemangioma cells, which, surprisingly, were fully proficient in in vivo growth. |
16741507 |
Human |
tie-2 |
haematological malignancies |
Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies. |
16978237 |
Human |
tie-2 |
tumor angiogenesis |
The system involving angiopoietin-2 (Ang-2) and its receptor, Tie-2, appears to play an important role not only in tumor angiogenesis, but also in the biology of haematological and non-haematological malignancies. |
16978237 |
Human |
tie-2 |
haematological malignancies |
The system involving angiopoietin-2 (Ang-2) and its receptor, Tie-2, appears to play an important role not only in tumor angiogenesis, but also in the biology of haematological and non-haematological malignancies. |
16978237 |
Human |
tie-2 |
haematological malignancies |
In the present study we evaluated the serum levels of soluble Ang-2 (sAng-2) and soluble Tie-2 (sTie-2) in patients with haematological malignancies. |
16978237 |
Human |
tie-2 |
oncoprotein |
We have found, in pregnancies complicated by placenta accreta: upregulated epidermal growth factor receptor and downregulated c-erbB-2 oncoprotein in syncytiotrophoblasts; downregulated vasculoendothelial growth factor receptor-2 expression in syncytiotro |
17197348 |
Human |
tie-2 |
esophageal cancer |
RESULTS: The expression of endothelial antigens vascular endothelial cadherin (CD144), P1H12 (CD146), tie-2, and VEGFR-2 correlated with each other in 54 samples of primary esophageal cancer (P < 0.0001 for all comparisons). |
17200341 |
Human |
tek |
leukemia |
We, therefore, analyzed blood cells of healthy donors and leukemia patients for expression of TEK and ang-1 by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and Northern blotting. |
11755466 |
NA |
tek |
solid tumors |
Tie2/tek receptor tyrosine kinase is a novel marker of microvasculature of solid tumors that appears to play a key role in the angiogenesis process in breast cancer. |
12527939 |
Human |
tek |
tumor |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Human |
tek |
tumor |
We also examined the effect of Tek-Delta Fc anti-angiogenic therapy on tumor growth and Tie2 expression patterns in HCT116 and WM115 subcutaneous xenografts. |
16314485 |
Human |
tek |
tumor |
Tek-Delta induced extensive tumor regression in HCT116 tumors and concomitant reductions in Tie2-expressing blood vessels. |
16314485 |
Human |
tek |
tumors |
Tek-Delta induced extensive tumor regression in HCT116 tumors and concomitant reductions in Tie2-expressing blood vessels. |
16314485 |
Human |
tie2 |
human small cell lung carcinomas |
Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas. |
10499626 |
Human |
tie2 |
small cell lung cancers |
We investigated their potential role and interaction in the development of lung cancers by comparing the expression pattern and inter-relationship of Ang-1 and 2, Tie2 and VEGF levels in 28 pairs of primary non-small cell lung cancers (NSCLC) and normal l |
10880843 |
Human |
tie2 |
tumor angiogenesis |
These findings support the hypothesis that tumor angiogenesis is dependent on VEGFR-2 but suggest that, in addition, tie2-dependent pathways of tumor angiogenesis may exist. |
11169947 |
Human |
tie2 |
tumor |
These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-1, Ang-2, and TIE2. |
11350896 |
Human |
tie2 |
hemangioma |
Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. |
11733376 |
Human |
tie2 |
hemangioma |
We found Tie2 mRNA and protein up-regulated with a concomitant increase in cellular responsiveness to Ang1 in most hemangioma-derived endothelial cells. |
11733376 |
Human |
tie2 |
hcc |
We have previously reported that angiopoietin (Ang), a ligand for Tie2 vascular endothelial-specific receptor tyrosine kinase, may play a role in the progression of human HCC (J Clin Invest 1999;103:341-345) and matrix proteinase expression (Cancer Res 20 |
11915032 |
Human |
tie2 |
hcc |
The Tie2 receptor protein was overexpressed in the neovascular endothelium of 31 of 39 (80%) human HCC tumors by immunohistochemical analysis with significant correlation to cell dedifferentiation and tumor size (P <.05). |
11915032 |
Human |
tie2 |
hcc |
In conclusion, tumorigenicity with neovascularization was suppressed by in vivo gene transfer and sTie2 expression in a murine HCC model, suggesting a possible role for Tie2 expression in the induction of HCC neovascularization and disease progression. |
11915032 |
Mouse |
tie2 |
tumorigenesis |
These findings identify an inhibitory role of Ang1/Tie2 receptor-mediated vessel maturation in SCC growth and suggest that up-regulation of its antagonist, Ang2, during early-stage epithelial tumorigenesis contributes to the angiogenic switch by counterac |
11943723 |
Human |
tie2 |
hccs |
Tie1 and Tie2 were overexpressed in large HCCs. |
12017318 |
Human |
tie2 |
rcc |
A significant increase in Ang-2 (p < 0.001) and a decrease in Tie2 receptor mRNA (p = 0.001) were observed, but no significant difference was observed in Ang-1 mRNA abundance between normal kidney and RCC (p = 0.37). |
12434420 |
Human |
tie2 |
solid tumors |
Tie2/tek receptor tyrosine kinase is a novel marker of microvasculature of solid tumors that appears to play a key role in the angiogenesis process in breast cancer. |
12527939 |
Human |
tie2 |
hcc |
To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology of hepatocellular carcinoma (HCC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HCC, 8 cirrhotic and 8 |
12539584 |
Human |
tie2 |
hcc |
Tie2 receptor was not expressed in controls, expressed at low level in cirrhotic liver (11.3 +/- 8.7/HP), while strongly positive in the microvascular endothelia of HCC (52.4 +/- 16.7/HP, P < 0.01). |
12539584 |
Human |
tie2 |
hcc |
The level of Tie2 receptor expression in HCC was closely related with tumor diameter, angiogenesis and portal invasion. |
12539584 |
Human |
tie2 |
hcc |
It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation, promoting the development and metastasis |
12539584 |
Human |
tie2 |
hcc |
Tumorigenicity with angiogenesis was suppressed by in vivo gene transfer and sTie2 expression in a murine HCC model, suggesting a possible role for angiopoietin/Tie2 signaling in the induction of HCC neovascularization and disease progression. |
12698880 |
Mouse |
tie2 |
hcc |
More important, inhibition of the angiopoietin/Tie2 signal transduction cascade is a promising approach for HCC treatment. |
12698880 |
Human |
tie2 |
hccs |
METHODS: The expression of the angiopoietin and Tie2 proteins was investigated in nine normal liver tissues and 52 surgically resected HCCs. |
14600132 |
Human |
tie2 |
hcc |
METHODS: RT-PCR and Western blot were employed to evaluate the VEGF/KDR and angiopoietins/Tie2 expression in samples from 23 patients with HCC. |
14627514 |
Human |
tie2 |
hcc |
CONCLUSIONS: The two signaling pathways, VEGF/KDR and angiopoietins/Tie2 are activated in the process of angiogenesis in HCC and modulate the formation of new blood vessels. |
14627514 |
Human |
tie2 |
tumor |
The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. |
14985859 |
Human |
tie2 |
aml |
Autocrine pathway of angiopoietins-Tie2 system in AML cells: association with phosphatidyl-inositol 3 kinase. |
15297853 |
Human |
tie2 |
aml |
After 48 h of culture with Tie2-Fc, nine AML cells from 19 examined samples were not influenced by Tie2-Fc (group A), while AML cells from remaining 10 patients demonstrated remarkable reduction of cell number by Tie2-Fc treatment (group B). |
15297853 |
Human |
tie2 |
aml |
These observations demonstrated that cells from a part of AML were dependent on autocrine Angs-Tie2 pathway. |
15297853 |
Human |
tie2 |
aml |
This notion was further supported by the study of two AML cell lines, KG-1 and HL-60: the growth of KG-1 was suppressed by Tie2-Fc, and also by anti-Tie2 antibody, which inhibits receptor-ligand interaction, while that of HL-60 was not suppressed by Tie2- |
15297853 |
Human |
tie2 |
human colorectal carcinoma |
There was considerable heterogeneity (Tie2-negative, Tie2-positive, or Tie2-composite blood vessels) in subcutaneous xenografts of human colorectal carcinoma (HCT116; 97.5% Tie2-positive vessels) versus human melanoma (WM115; 75.9% Tie2-positive vessels). |
16314485 |
Human |
tie2 |
melanoma |
There was considerable heterogeneity (Tie2-negative, Tie2-positive, or Tie2-composite blood vessels) in subcutaneous xenografts of human colorectal carcinoma (HCT116; 97.5% Tie2-positive vessels) versus human melanoma (WM115; 75.9% Tie2-positive vessels). |
16314485 |
Human |
tie2 |
tumor |
Tek-Delta induced extensive tumor regression in HCT116 tumors and concomitant reductions in Tie2-expressing blood vessels. |
16314485 |
Human |
tie2 |
tumors |
Tek-Delta induced extensive tumor regression in HCT116 tumors and concomitant reductions in Tie2-expressing blood vessels. |
16314485 |
Human |
tie2 |
glioma |
We show that Ang2 interacts with alpha(v)beta(1) integrin in Tie2-deficient human glioma cells, activating focal adhesion kinase (FAK), p130(Cas), extracellular signal-regulated protein kinase (ERK) 1/2, and c-jun NH(2)-terminal kinase (JNK) and substanti |
16424009 |
Human |
tie2 |
ptc |
RTQ-PCR demonstrated that VEGF, its receptors VEGFR-1 and VEGFR-2, and angiopoietin-2 and its receptor (Tie2) were also overexpressed (P < 0.05) in PTC. |
16712675 |
Human |
tie2 |
hcc |
METHODS: Fresh surgically resected specimens of HCC and noncancerous liver (NCL) tissue from 38 patients with HCC were obtained, and expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tie2, and VEGF messenger RNA (mRNA) was examined by real-tim |
16830384 |
Human |
tie2 |
hcc |
RESULTS: Ang-2 and VEGF mRNAs in HCC were significantly higher than those in NCL tissue (P < 0.05), whereas the Ang-1 and Tie2 mRNAs showed no statistical significance (P > 0.05), though slightly lower level of Ang-1 mRNA in HCC was observed. |
16830384 |
Human |
tie2 |
hyperplasia |
Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. |
16917117 |
Human |
tie2 |
hyperplasia |
CONCLUSIONS: The Ang1/Tie2 pathway is potentiated in iPAH, contributing to PA-SMC hyperplasia via increased stimulation of endothelium-derived growth factors synthesis by P-ECs. |
16917117 |
Human |
tie2 |
venous malformations |
However, due to detailed analysis inherited forms have been observed, which has led to identify mutations in three genes causing familial vascular malformations: in the angiopoietin receptor TIE2 in mucocutaneous venous malformations (VMCM), in glomulin i |
16997448 |
Human |
tie2 |
leukemia |
Recently, Tie2 has also been found in the nonvascular compartment of several tumors, including leukemia as well as breast, gastric, and thyroid cancers. |
17189382 |
Human |
tie2 |
tumors |
Recently, Tie2 has also been found in the nonvascular compartment of several tumors, including leukemia as well as breast, gastric, and thyroid cancers. |
17189382 |
Human |
tie2 |
thyroid cancers |
Recently, Tie2 has also been found in the nonvascular compartment of several tumors, including leukemia as well as breast, gastric, and thyroid cancers. |
17189382 |
Human |
tie2 |
human tumors |
There is, however, little information on the function of the Ang1/Tie2 pathway in the non-stromal cells within human tumors. |
17189382 |
Human |
tie2 |
glioblastoma |
We found that surgical glioblastoma specimens contained a subpopulation of Tie2+/CD31- and Tie2+/GFAP+ cells, suggesting that Tie2 is indeed expressed outside the vascular compartment of gliomas. |
17189382 |
Human |
tie2 |
gliomas |
We found that surgical glioblastoma specimens contained a subpopulation of Tie2+/CD31- and Tie2+/GFAP+ cells, suggesting that Tie2 is indeed expressed outside the vascular compartment of gliomas. |
17189382 |
Human |
tie2 |
glioma |
Furthermore, analysis of a tissue array consisting of 116 human glioma samples showed that Tie2 expression in the neoplastic glial cells was significantly associated with progression from a lower to higher grade. |
17189382 |
Human |
tie2 |
glioma |
Importantly, Ang1 stimulation of Tie2+ glioma cells resulted in increased adherence of the cells to collagen I and IV, suggesting that Tie2 regulates glioma cell adhesion to the extracellular matrix. |
17189382 |
Human |
tie2 |
gliomas |
These results, together with the reported fact that malignant gliomas express high levels of Ang1, suggest the existence of an autocrine loop in malignant gliomas and that a Tie2-dependent pathway modulates cell-to-extracellular matrix adhesion, providing |
17189382 |
Human |
tie2 |
malignant gliomas |
These results, together with the reported fact that malignant gliomas express high levels of Ang1, suggest the existence of an autocrine loop in malignant gliomas and that a Tie2-dependent pathway modulates cell-to-extracellular matrix adhesion, providing |
17189382 |
Human |
tie-2 |
ibd |
CONCLUSIONS: Serum Ang-2 and Tie-2 levels are elevated in patients with IBD. |
16436095 |
Human |
tie-2 |
thyroid cancers |
Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers. |
17374490 |
Human |
tie-2 |
follicular cancers |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
papillary cancers |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
anaplastic cancers |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
ptc |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
thyroid cancer |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
medullary cancers |
We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of papillary cancers, PTC; 8 follicular cancers, FTC; 12 medullary cancers, MTC and 11 |
17374490 |
Human |
tie-2 |
thyroid cancer |
The levels of Ang-2 and Tie-2 did not differ significantly between thyroid cancer patients and control. |
17374490 |
Human |
tie-2 |
cancer |
We have also compared the results of Ang-1, Ang-2, and Tie-2 determinations obtained in different histopathological subgroups of cancer patients. |
17374490 |
Human |
tie-2 |
ptc |
We have also observed lower Ang-2 concentration in PTC patients (p<0.03) and Tie-2 in FTC patients (p<0.02 ) in comparison to controls. |
17374490 |
Human |
tie-2 |
thyroid cancers |
In conclusion, the Angs/Tie-2 system dysfunction may play an important role in thyroid cancerogenesis and decreased concentration of Ang-1 in serum can be a useful additional biomarker for the presence of thyroid cancers. |
17374490 |
Human |
tie-2 |
ductal carcinoma |
The current study sought to examine the levels of the expression of Ang-1, Ang-2, Ang-3 and their receptor Tie-2 in mammary ductal carcinoma and to assess their relevance to prognosis. |
17381833 |
Human |
tie-2 |
acute myeloid leukemias |
Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. |
17446561 |
Human |
tie-2 |
acute myeloid leukemia (aml) |
We investigated the expression of Tie-2 in primary blasts from 111 patients with acute myeloid leukemia (AML) to evaluate a possible linkage between the expression of this receptor and the immunophenotypic and biologic properties of leukemic blasts. |
17446561 |
Human |
tie-2 |
aml |
The analysis of the immunophenotype clearly showed that Tie-2 expression in AML was associated with monocytic features. |
17446561 |
Human |
tie-2 |
aml |
Interestingly, Tie-2 expression on AML blasts was associated with concomitant expression of other receptors for endothelial growth factors, such as vascular endothelial growth factor receptor 1 (VEGF-R1), -R2, and -R3. |
17446561 |
Human |
tie-2 |
aml |
The autocrine angiopoietin/Tie-2 axis may represent a promising therapeutic target to improve the outcome of patients with monocytic AML. |
17446561 |
Human |
tie-2 |
tumor |
In this paper, the structure and action mechanism of Ang family and its receptor Tie-2, the application of Ang family and Tie in tumor therapy, and the synergic mechanism between Ang and VEGF were summarized. |
17493367 |
Human |
tie-2 |
into tumours |
This in turn then recruits Tie-2-expressing monocytes into tumours from the bloodstream and inhibits their production of anti-apoptotic and anti-angiogenic cytokines. |
17601353 |
Human |
tie-2 |
tumor |
Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and vascular extravasation. |
17634421 |
Human |
tie-2 |
malignancy |
Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and vascular extravasation. |
17634421 |
Human |
tie-2 |
tumor angiogenesis |
Collectively, these TIE-2-dependent and TIE-2-independent activities may account for the conflicting findings of ANG-1 and ANG-2 in tumor angiogenesis. |
17634421 |
Human |
tie-2 |
colorectal adenocarcinoma |
We examined the expression profiles of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF), and Tie-2, a receptor for Ang-1 and Ang-2, in both colorectal adenocarcinoma and adjacent normal tissues, as judged by histol |
17785951 |
Human |
tie-2 |
adenocarcinoma |
In contrast, the expression of Ang-1 was lower in adenocarcinoma tissues than in adjacent normal tissues (p < 0.01), while there was no significant difference in Tie-2 expression in both tissues. |
17785951 |
Human |
tie-2 |
aml |
We determined the marrow levels of seven molecules associated with angiogenesis in 52 AML patients before chemotherapy and 20 healthy controls: VEGF-A, VEGF/PlGF, VEGF-C, VEGF-D, Ang-1, Ang-2, and Tie-2. |
17848952 |
Human |
tie-2 |
aml |
Comparing to normal controls, the marrow levels of VEGF/PlGF, Ang-2, and Tie-2 were significantly higher, and those of VEGF-C and Ang-1 were significantly lower in the AML patients (P<0.001). |
17848952 |
Human |
tie2 |
hepatocellular carcinoma |
[Expression of Ang2 and Tie2 and their relation with the angiogenesis of hepatocellular carcinoma in rats] OBJECTIVE: To investigate the relationship between the expression of Ang2, Tie2 and the angiogenesis of hepatocellular carcinoma in rats. |
16951510 |
Human |
tie2 |
hepatocellular carcinoma |
CONCLUSION: The up-regulation of Ang2 and Tie2 may play important roles in the angiogenesis of hepatocellular carcinoma. |
16951510 |
Human |
tie2 |
cancer |
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. |
17327411 |
Human |
tie2 |
tumor |
We recently described a lineage of mouse monocytes characterized by expression of the Tie2 angiopoietin receptor and required for the vascularization and growth of several tumor models. |
17327411 |
Mouse |
tie2 |
tumors |
In vitro, TEMs migrated toward angiopoietin-2, a TIE2 ligand released by activated endothelial cells and angiogenic vessels, suggesting a homing mechanism for TEMs to tumors. |
17327411 |
Human |
tie2 |
breast cancer |
In cell culture, Ang2 promotes cell migration and invasion in Tie2-deficient breast cancer cells through the alpha(5)beta(1) integrin/integrin-linked kinase (ILK)/Akt, GSK-3beta/Snail/E-cadherin signaling pathway. |
17483337 |
Human |
tie2 |
acute myeloid leukemia (aml) |
We investigated the impact of circulating angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and soluble Tie2 (sTie2) on overall survival in patients with acute myeloid leukemia (AML). |
17597808 |
Human |
tie2 |
tumor angiogenesis |
Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. |
17875679 |
Human |
tie2 |
tumor |
A ligand for Tie2, angiopoietin-2 (Ang-2), is produced by angiogenic tumor vessels and is a chemoattractant for TEMs. |
17875679 |
Human |
tie 2 |
tumor |
When a tumor stroma targeted therapy inhibiting the tie 2 receptor and the PDGF-Rbeta simultaneously was added to castration it resulted in a decreased vascular density, increased tumor cell apoptosis and decreased tumor growth compared to castration alon |
17854058 |
Rat |
tie-2 |
schwannomas |
Immunohistochemical staining revealed that 66.7% of GISTs (20 of 30), 76.5% of leiomyomas (13 of 17) and 83.3% of schwannomas (5 of 6) were positive for Ang-1. 83.3% of GISTs (25 of 30), 82.4% of leiomyomas (14 of 17) and 100% of schwannomas (6 of 6) were |
17724803 |
Human |
tie-2 |
breast cancer |
METHODS: The tissue expression of VEGF, Flt-1, and Tie-2 were investigated by immunohistochemistry, and plasma levels assessed by enzyme-linked immunosorbent assay in 36 patients with breast cancer and 15 with benign breast disease. |
18091379 |
Human |
tie-2 |
breast cancer |
RESULTS: Despite expected significant differences in plasma levels of the molecules (P<0.03 to <0.001), no significant differences were found in Tie-2, VEGF, and Flt-1 tissue expression between breast cancer and benign disease controls. |
18091379 |
Human |
tie-2 |
cancer |
CONCLUSIONS: Tissue expression of Tie-2, VEGF, and Flt-1 may not be an overly sensitive tool for assessing abnormalities of coagulation, platelet activation, and angiogenesis in human cancer. |
18091379 |
Human |
tie-2 |
hyperplasia |
Interestingly, treatment of Tie-2 transgenic mice with anti-CD4 antibody appeared to resolve aspects of inflammation but did not resolve epidermal hyperplasia, suggesting an important role for eosinophils in mediating the inflammatory skin disease observe |
18443190 |
Mouse |
tie-2 |
prostate cancer |
The mRNA and protein secretion of the Angs, Tie-2 and VEGF were measured by real-time polymerase chain reaction and enzyme-linked immunosorbent assays, respectively, in LNCaP (AD) and LNCaP-19, C4-2, C4-2B4 and PC-3 (AI) prostate cancer xenografts in mice |
18489523 |
Human |
tie-2 |
human tumours |
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. |
18676144 |
Human |
tie-2 |
glioma |
[Roles of angiopoietin-2, Tie-2 and hypoxia-inducible factor 1alpha in angiogenesis of glioma] |
18788598 |
Human |
tie2 |
gliomas |
Recently, we reported the expression of the Ang-natural receptor, Tie2, in neoplastic astrocytic cells within gliomas. |
17704802 |
Human |
tie2 |
gliomas |
Because of the VEGF/Ang2 functional partnership together with the presence of Tie2 in gliomas, we hypothesized a role of Ang2 on the modulation of VEGF levels in these tumors. |
17704802 |
Human |
tie2 |
tumors |
Because of the VEGF/Ang2 functional partnership together with the presence of Tie2 in gliomas, we hypothesized a role of Ang2 on the modulation of VEGF levels in these tumors. |
17704802 |
Human |
tie2 |
glioma |
We examined the effect of Ang2 on VEGF expression in a panel of glioma cells, which showed that Ang2 inhibited VEGF expression at both mRNA and protein levels in Tie2-expressing cells, but not in Tie2-negative cells. |
17704802 |
Human |
tie2 |
tumor |
Tie2 staining was detectable in small and large vessels of all tumor zones. |
17849463 |
Human |
tie2 |
aml |
We investigated the expression of Ang-1, Ang-2, Tie2, VEGF-A, and VEGF-C genes in bone marrow (BM) mononuclear cells by real-time quantitative PCR (RQ-PCR) in a cohort of 126 patients with newly diagnosed de novo AML and normal marrow donors. |
17904634 |
Human |
tie2 |
tumor |
BACKGROUND: Cellular events mediated by the Tie2 receptor are important to tumor neovascularization. |
17950331 |
Human |
tie2 |
tumor angiogenesis |
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications. |
17981504 |
Mouse |
tie2 |
tumor angiogenesis |
A subset of monocytes that express the angiopoietin receptor Tie2 play an important role in tumor angiogenesis. |
17981504 |
Human |
tie2 |
tumor angiogenesis |
Selective depletion of these Tie2-expressing monocytes (TEMs) in tumor-bearing mice inhibits tumor angiogenesis and growth, suggesting that they might regulate angiogenic processes in tumors by providing paracrine support to nascent blood vessels. |
17981504 |
Mouse |
tie2 |
tumors |
Selective depletion of these Tie2-expressing monocytes (TEMs) in tumor-bearing mice inhibits tumor angiogenesis and growth, suggesting that they might regulate angiogenic processes in tumors by providing paracrine support to nascent blood vessels. |
17981504 |
Mouse |
tie2 |
tumors |
A transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in xenograft tumors. |
18237547 |
Mouse |
tie2 |
tumors |
In plastic EW7 Ewing sarcoma tumors in these Tie2-GFP mice, we observed blood flow in both regular blood vessels and non-fluorescent tumor cell-lined channels, visualizing in vivo hemodynamics in vasculogenic channels. |
18237547 |
Mouse |
tie2 |
ewing sarcoma |
In plastic EW7 Ewing sarcoma tumors in these Tie2-GFP mice, we observed blood flow in both regular blood vessels and non-fluorescent tumor cell-lined channels, visualizing in vivo hemodynamics in vasculogenic channels. |
18237547 |
Mouse |
tie2 |
cancer |
Aberrant expression and activity of Tie2 in vascular and non-vascular cells may result in the development of rheumatoid arthritis, cancer, hypertension and psoriasis. |
18266978 |
Human |
tie2 |
hemangioma |
[Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma] OBJECTIVE: To investigate the relationship of angiogenesis and the Ang family members/ receptor (Ang/Tie2) in hemangioma. |
18269030 |
Human |
tie2 |
hemangioma |
METHODS: Expression of Ang1, Ang2 and the receptor Tie2 was detected with immunohistochemical SP method and RT-PCR method in 17 cases of proliferating hemangioma, 13 involuting cases and 10 cases of normal children skin. |
18269030 |
Human |
tie2 |
hemangiomas |
RESULTS: The expression of Ang2 and Tie2 was higher markedly in proliferating hemangiomas than in involuting hemangiomas (P < 0.01), and was rare or negative in normal skin. |
18269030 |
Human |
tie2 |
hemangioma |
CONCLUSION: Ang/Tie2 system may play an important role in the proliferating and involuting process of hemangioma. |
18269030 |
Human |
tie2 |
solid tumors |
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domain-2 (Tie2) has been considered as a rational target for gene therapy in solid tumors. |
18330476 |
Human |
tie2 |
tumors |
In the biodistribution assay, (125)I-GA5 was mainly accumulated in SPC-A1 xenograft tumors that express Tie2. |
18330476 |
Mouse |
tie2 |
ewing's sarcoma |
In order to further characterize the role of stem/progenitor cells in Ewing's sarcoma, we sorted Tie2(-) BM cells from Tie2-GFP transgenic mice and then injected them intravenously into Ewing's tumor-bearing mice. |
18344025 |
Human |
tie2 |
ewing's tumor |
In order to further characterize the role of stem/progenitor cells in Ewing's sarcoma, we sorted Tie2(-) BM cells from Tie2-GFP transgenic mice and then injected them intravenously into Ewing's tumor-bearing mice. |
18344025 |
Human |
tie2 |
ewing's tumors |
Tie2(-) BM progenitors migrated to Ewing's tumors and differentiated into Tie2(+) cells occupying a perivascular residence and expressing alpha-smooth muscle actin, desmin and PDGFR-beta, as well as VEGFR-2. |
18344025 |
Mouse |
tie2 |
tumors |
We did not observe differentiation of Tie2(-) cells into Tie2(+) perivascular cells in VEGF(165)-inhibited TC/siVEGF(7-1) tumors. |
18344025 |
Mouse |
tie2 |
tumor |
The differentiation of Tie2(-) BM cells into Tie2(+) cells in parental but not VEGF(165)-inhibited tumors indicates that the tumor microenvironment may influence the differentiation pathway. |
18344025 |
Mouse |
tie2 |
tumors |
The differentiation of Tie2(-) BM cells into Tie2(+) cells in parental but not VEGF(165)-inhibited tumors indicates that the tumor microenvironment may influence the differentiation pathway. |
18344025 |
Mouse |
tie2 |
cancer |
Tie2: a journey from normal angiogenesis to cancer and beyond. |
18366015 |
Human |
tie2 |
venous malformations |
Tie2 also seems to play a crucial role in several vascular abnormalities, such as familial venous malformations. |
18366015 |
Human |
tie2 |
cancer |
In cancer, Tie2 was originally found to be overexpressed in tumoral vessels. |
18366015 |
Human |
tie2 |
breast tumors |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
gliomas |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
leukemia |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
gastric tumors |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
solid neoplasms |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
cancer |
More recently, our laboratory and others have found that Tie2 is also expressed outside the vascular compartment in several types of cancer, including leukemia and solid neoplasms such as gastric tumors, breast tumors, and gliomas. |
18366015 |
Human |
tie2 |
glioma |
In this regard, our group reported the importance of Tie2-expressing glioma cells in their adhesion to the tumoral microenvironment. |
18366015 |
Human |
tie2 |
tumor |
Because cancer may be considered as a complex organ with several cellular lineages coexisting in the same tumor, the expression of Tie2 by different tumoral compartments makes this cellular receptor an attractive target for cancer therapy. |
18366015 |
Human |
tie2 |
cancer |
Because cancer may be considered as a complex organ with several cellular lineages coexisting in the same tumor, the expression of Tie2 by different tumoral compartments makes this cellular receptor an attractive target for cancer therapy. |
18366015 |
Human |
tie2 |
tumors |
Consequently, although vascular endothelial growth factor gene expression was not detected with significant differences among the cases, significant downregulation of Tie2 gene expression was observed in all SQMG-sensitive tumors as compared with controls |
18380795 |
Human |
tie2 |
tumors |
These data suggested that the antitumor effects of SQMG could be attributed to antiangiogenic effects, possibly via the downregulation of Tie2 gene expression in SQMG-sensitive tumors. |
18380795 |
Human |
tie2 |
venous malformations |
Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. |
18401423 |
Human |
tie2 |
metastasis |
Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. |
18835032 |
Human |
tie2 |
tumor |
Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. |
18835032 |
Human |
tie2 |
tumor |
Here, we exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to deliver IFN-alpha to tumors. |
18835032 |
Human |
tie2 |
tumors |
Here, we exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to deliver IFN-alpha to tumors. |
18835032 |
Human |
tie2 |
metastasis |
By transplanting hematopoietic progenitors transduced with a Tie2 promoter/enhancer-driven Ifna1 gene, we turned TEMs into IFN-alpha cell vehicles that efficiently targeted the IFN response to orthotopic human gliomas and spontaneous mouse mammary carcino |
18835032 |
Human |
tie2 |
gliomas |
By transplanting hematopoietic progenitors transduced with a Tie2 promoter/enhancer-driven Ifna1 gene, we turned TEMs into IFN-alpha cell vehicles that efficiently targeted the IFN response to orthotopic human gliomas and spontaneous mouse mammary carcino |
18835032 |
Human |
tie2 |
mammary carcinomas |
By transplanting hematopoietic progenitors transduced with a Tie2 promoter/enhancer-driven Ifna1 gene, we turned TEMs into IFN-alpha cell vehicles that efficiently targeted the IFN response to orthotopic human gliomas and spontaneous mouse mammary carcino |
18835032 |
Mouse |
tie-2 |
giant cell tumor |
Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: a possible role in synovial proliferation. |
11261813 |
Human |
tie2 |
hepatocellular carcinoma |
To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology of hepatocellular carcinoma (HCC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HCC, 8 cirrhotic and 8 |
12539584 |
Human |
tie2 |
hepatocellular carcinoma |
OBJECTIVE: To explore the effect of two dominating signaling pathways, VEGF/KDR and angiopoietins/Tie2, on the formation of new blood vessel in hepatocellular carcinoma (HCC) growth and metastasis. |
14627514 |
Human |
tie2 |
hepatocellular carcinoma |
AIM: To investigate the significance of angiopoietins, Tie2 and vascular endothelial growth factor (VEGF) expression in the angiogenesis and progress of hepatocellular carcinoma (HCC). |
16830384 |
Human |
tie2 |
acute myeloid leukemia |
DESIGN AND METHODS: We investigated the expression of Ang-1, Ang-2 and Tie2 by immunohistochemical analyses in bone marrow biopsies of 64 adult patients with newly diagnosed acute myeloid leukemia (AML) and correlated angiogenic factor expression with cli |
16956819 |
Human |
tie2 |
acute myeloid leukemia |
We investigated the impact of circulating angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and soluble Tie2 (sTie2) on overall survival in patients with acute myeloid leukemia (AML). |
17597808 |
Human |
tie2 |
tumor |
In plastic EW7 Ewing sarcoma tumors in these Tie2-GFP mice, we observed blood flow in both regular blood vessels and non-fluorescent tumor cell-lined channels, visualizing in vivo hemodynamics in vasculogenic channels. |
18237547 |
Mouse |
tie2 |
tumor |
In addition, we showed that GA5 was internalized into tumor cells highly expressing Tie2. |
18330476 |
Mouse |