IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene THBS2 Ensembl ENSG00000186340 Chromosome 6 Start 169357801 End 169396062
Description Thrombospondin-2 Precursor [Source:UniProtKB/Swiss-Prot;Acc:P35442]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11786
     Entrez Gene : 7058
     UCSC : uc003qwt.2
     GeneCards : 11786
     RefSeq : NM_003247
     CCDS : CCDS34574.1
     Uniprot : P35442
     Interpro : P35442
     OMIM : 188061
     GeneTests : THBS2
     CGAP : THBS2
     PMID : 18455130

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  658_at  1.52  2.29e-8  2.16e-7  2.05  2.04e-10  2.60e-9
 HG_U95  659_g_at  1.33  4.07e-11  6.51e-10  1.55  6.05e-9  5.76e-8
 HG_U133A  203083_at  1.34  8.25e-26  9.62e-25  -0.77  3.77e-13  4.96e-13
 HG_U133_Plus2  203083_at  1.86  1.98e-23  6.69e-22  2.10  2.63e-23  5.40e-22
 Stanford  834  2.28  2.22e-6  2.39e-4  1.83  1.90e-3  2.17e-2
 Agilent_HS_21.6K  9213  0.50  2.31e-3  1.49e-2  0.52  2.85e-4  1.91e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203083_at  -0.36  4.38e-1  9.13e-1  -0.11  6.77e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 658_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 659_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203083_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203083_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 834    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9213    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tsp-2 neoplasia MATERIALS AND METHODS: The expression of TSP-1, TSP-2 and CD36 receptor was assessed in 73 tissue specimens using immunohistochemistry; specimens were from 32 patients with BPH, seven with prostatic intraepithelial neoplasia (PIN) and 34 with cancer. 15180634 Human
thrombospondin-2 tumor Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy. 11929817 Human
tsp-2 tumor We established a tissue-engineered implant system for the continuous in vivo production of thrombospondin-2 (TSP-2), a potent endogenous inhibitor of tumor growth and angiogenesis. 11929817 Human
thrombospondin-2 tumor We established a tissue-engineered implant system for the continuous in vivo production of thrombospondin-2 (TSP-2), a potent endogenous inhibitor of tumor growth and angiogenesis. 11929817 Human
tsp-2 human squamous cell carcinomas Bioimplant-generated TSP-2 potently inhibited tumor growth and angiogenesis of human squamous cell carcinomas, malignant melanomas, and Lewis lung carcinomas that were implanted at a distant site. 11929817 Human
tsp-2 lewis lung carcinomas Bioimplant-generated TSP-2 potently inhibited tumor growth and angiogenesis of human squamous cell carcinomas, malignant melanomas, and Lewis lung carcinomas that were implanted at a distant site. 11929817 Human
tsp-2 tumor Bioimplant-generated TSP-2 potently inhibited tumor growth and angiogenesis of human squamous cell carcinomas, malignant melanomas, and Lewis lung carcinomas that were implanted at a distant site. 11929817 Human
tsp-2 malignant melanomas Bioimplant-generated TSP-2 potently inhibited tumor growth and angiogenesis of human squamous cell carcinomas, malignant melanomas, and Lewis lung carcinomas that were implanted at a distant site. 11929817 Human
tsp-2 cervical cancer Comparing gene transcript levels between recurrent and non-recurrent cervical cancer patients revealed significant differences (P=0.038) in transcript levels for the angiogenesis inhibitor TSP-2, with the highest levels in non-recurrent cases. 12189553 Human
tsp-2 cervical cancer In cervical cancer, TSP-2 appears only to be highly co-expressed with MMP-2 (P<0.0001). 12189553 Human
thrombospondin 2 metastatic malignant melanoma Differential expression of thrombospondin 2 in primary and metastatic malignant melanoma. 12353704 Human
thrombospondin 2 melanoma Here, we show that thrombospondin 2, an extracellular matrix molecule which was differentially regulated in the microarray analysis, was strongly expressed in melanoma metastases, but not in primary tumours. 12353704 Human
thrombospondin 2 metastases Here, we show that thrombospondin 2, an extracellular matrix molecule which was differentially regulated in the microarray analysis, was strongly expressed in melanoma metastases, but not in primary tumours. 12353704 Human
thrombospondin 2 metastasis The identification of thrombospondin 2 as a target molecule emphasizes the importance of cell-matrix interactions for the pathogenesis of malignant melanoma metastasis and may open future perspectives for treatment of this tumour. 12353704 Human
thrombospondin 2 malignant melanoma The identification of thrombospondin 2 as a target molecule emphasizes the importance of cell-matrix interactions for the pathogenesis of malignant melanoma metastasis and may open future perspectives for treatment of this tumour. 12353704 Human
thrombospondin 2 tumour The identification of thrombospondin 2 as a target molecule emphasizes the importance of cell-matrix interactions for the pathogenesis of malignant melanoma metastasis and may open future perspectives for treatment of this tumour. 12353704 Human
tsp2 aldosterone-producing adenomas All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas (APA)) expressed both TSP1 and TSP2 mRNAs. 12358136 Human
tsp2 adenomas All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas (APA)) expressed both TSP1 and TSP2 mRNAs. 12358136 Human
tsp2 adenomas No significant differences in TSP1 and TSP2 expressions were found between control adrenals and nonfunctional adenomas. 12358136 Human
thrombospondin-2 melanoma A CD47 antibody (B6H12) that inhibited alphavbeta3-mediated adhesion of melanoma cells induced by CD47-binding peptides from thrombospondin-1 directly stimulated alpha4beta1-mediated adhesion of the same cells to vascular cell adhesion molecule-1 and N-te 12218055 Human
thrombospondin 2 tumor Our results indicate that BAI1 and TIMP-2 expressions in the extraneoplastic mucosa and non-metastatic lymph nodes were not suppressed in the patients with good prognosis, but increased expressions of angiopoietin 2, thrombospondin 2, TIMP-2, nm23 and E-c 11172604 Human
tsp-2 tumor Surprisingly, TSP-2 expression was strongly upregulated in the mesenchymal stroma of wild-type mice throughout the consecutive stages of tumorigenesis whereas the angiogenesis factor, vascular endothelial growth factor, was induced predominantly in tumor 11387198 Mouse
tsp-2 tumor TSP-2 deficiency dramatically enhanced susceptibility to skin carcinogenesis and resulted in accelerated and increased tumor formation. 11387198 Human
tsp-2 tumor While TSP-2 deficiency did not affect tumor differentiation or proliferation, tumor cell apoptosis was significantly reduced. 11387198 Human
tsp-2 endometrial cancer Expression of TSP-1 and TSP-2 were assessed by reverse transcriptase-polymerase chain reaction in 18 normal endometrium and 55 endometrial cancer samples. 11445843 Human
tsp-2 endometrial cancer Expression of TSP-1 and TSP-2 was detected in 33 (60.0%) and 15 cases (27.3%), respectively, of 55 endometrial cancer samples. 11445843 Human
tsp-2 invasive cervical cancer EXPERIMENTAL DESIGN: Gene expression of TSP-1 and TSP-2 was assessed by reverse transcription-PCR in 10 normal cervix and 78 invasive cervical cancer samples. 11555600 Human
tsp-2 cervical cancer TSP-2 mRNA expression in normal cervix was significantly higher than that in cases involving cervical cancer (P = 0.032). 11555600 Human
tsp-2 tumors Expression of TSP-1 and TSP-2 mRNA was significantly lower in tumors exhibiting parametrial invasion (P = 0.016 and P = 0.049, respectively). 11555600 Human
tsp-2 epithelial ovarian tumors MATERIALS AND METHODS: Gene expression of TSP-1 and TSP-2 was assessed by reverse transcriptase-polymerase chain reaction in 6 borderline and 29 malignant epithelial ovarian tumors. 11712798 Human
tsp-2 epithelial ovarian tumors Results: TSP-1 mRNA expression was detected in 14 out of the 29 malignant epithelial ovarian tumors (48.3%), whereas TSP-2 mRNA expression was detected in 7 malignant epithelial ovarian tumors (24.1%). 11712798 Human
tsp-2 tumors TSP-2 expression was significantly higher in tumors with massive ascites. 11712798 Human
thrombospondin 2 tumor Tissue factor (TF) produced by tumor cells has been implicated in the regulation of this "angiogenic switch" through its ability to concurrently induce the expression of angiogenic molecules such as vascular endothelial cell growth factor (VEGF) 10821491 Human
tsp-2 malignant glioma Reverse transcription-polymerase chain reaction analysis showed that nine of nine malignant glioma cell lines expressed TSP-1 mRNA, and seven of nine glioma lines expressed TSP-2 mRNA. 11132930 Human
tsp-2 glioma Reverse transcription-polymerase chain reaction analysis showed that nine of nine malignant glioma cell lines expressed TSP-1 mRNA, and seven of nine glioma lines expressed TSP-2 mRNA. 11132930 Human
tsp-2 squamous-cell carcinomas In particular, thrombospondin-1 (TSP-1) and TSP-2 are expressed in normal skin and, when introduced into squamous cell carcinomas, potently inhibit malignant tumor growth via inhibition of tumor angiogenesis. 11147670 Human
thrombospondin 2 colorectal cancers We examined expression of genes encoding various angiostatic factors: thrombospondin 1 (TSP1), thrombospondin 2 (TSP2), brain-specific angiogenesis inhibitor 1 (BAI1) and angiopoietin 2 (AGP2) in 62 colorectal cancers and 40 samples of extraneoplastic col 10568831 Human
tsp2 colorectal cancers We examined expression of genes encoding various angiostatic factors: thrombospondin 1 (TSP1), thrombospondin 2 (TSP2), brain-specific angiogenesis inhibitor 1 (BAI1) and angiopoietin 2 (AGP2) in 62 colorectal cancers and 40 samples of extraneoplastic col 10568831 Human
thrombospondin-2 tumor Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. 10611308 Human
tsp-2 tumor To directly examine the biological effect of TSP-2 expression on tumor growth and angiogenesis, human A431 squamous cell carcinoma cells, which do not express TSP-2, were stably transfected with a murine TSP-2 expression vector or with vector alone. 10611308 Human
tsp-2 squamous-cell carcinoma To directly examine the biological effect of TSP-2 expression on tumor growth and angiogenesis, human A431 squamous cell carcinoma cells, which do not express TSP-2, were stably transfected with a murine TSP-2 expression vector or with vector alone. 10611308 Human
tsp-2 tumor However, injection of TSP-2-transfected clones into the dermis of nude mice resulted in pronounced inhibition of tumor growth that was significantly stronger than the inhibition observed in A431 clones stably transfected with a thrombospondin-1 (TSP-1) ex 10611308 Mouse
tsp-2 tumor These findings establish TSP-2 as a potent endogenous inhibitor of tumor growth and angiogenesis. 10611308 Human
thrombospondin 2 metastasis Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. 9888480 Human
thrombospondin 2 colon cancer Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. 9888480 Human
tsp-2 colon cancers We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cancers. 9888480 Human
tsp-2 hepatic metastasis Thirty-eight of these 61 colon cancers were positive for TSP-2 expression and showed hepatic metastasis at a significantly lower incidence than those without TSP-2 expression (P = 0.02). 9888480 Human
tsp-2 colon cancers Thirty-eight of these 61 colon cancers were positive for TSP-2 expression and showed hepatic metastasis at a significantly lower incidence than those without TSP-2 expression (P = 0.02). 9888480 Human
tsp-2 colon cancers TSP-2 expression was significantly associated with M0 stage in these colon cancers (P = 0.03), whereas TSP-1 expression showed no apparent correlation with these factors. 9888480 Human
tsp-2 colon cancer The colon cancer patients with TSP-2 expression showed a significantly low frequency of liver metastasis correlated with the cell-associated isoform of vascular endothelial growth factor (VEGF-189) (P = 0.0006). 9888480 Human
tsp-2 liver metastasis The colon cancer patients with TSP-2 expression showed a significantly low frequency of liver metastasis correlated with the cell-associated isoform of vascular endothelial growth factor (VEGF-189) (P = 0.0006). 9888480 Human
tsp-2 metastasis These results suggest that colon cancer metastasis is critically determined by angiogenesis resulting from the balance between the angioinhibitory factor TSP-2 and angiogenic factor VEGF-189. 9888480 Human
tsp-2 colon cancer These results suggest that colon cancer metastasis is critically determined by angiogenesis resulting from the balance between the angioinhibitory factor TSP-2 and angiogenic factor VEGF-189. 9888480 Human
thrombospondin 2 human colon carcinoma Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line. 12792739 Human
tsp2 human colon carcinoma Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line. 12792739 Human
thrombospondin 2 tumor Thrombospondin 2 (TSP2) is an extracellular matrix glycoprotein involved in tumor progression and angiogenesis. 12792739 Human
tsp2 tumor Thrombospondin 2 (TSP2) is an extracellular matrix glycoprotein involved in tumor progression and angiogenesis. 12792739 Human
tsp2 colon carcinoma We evaluated whether overexpression of the TSP2 gene show an alteration of various genes by cDNA arrays in the colon carcinoma cell line SW480. 12792739 Human
tsp2 human colon cancer We cloned and transfected human TSP2 cDNA into the human colon cancer cell line SW-480. 11788898 Human
thrombospondin-2 glioma Thrombospondin-2 (TSP2) expression is inversely correlated with vascularity in glioma. 10448307 Human
tsp2 glioma Thrombospondin-2 (TSP2) expression is inversely correlated with vascularity in glioma. 10448307 Human
tsp2 glioma These results indicate that the lack of TSP2 gene expression is a potent factor for enhancement of angiogenesis in glioma. 10448307 Human
thrombospondin-2 tumor An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo. 14675207 Human
tsp-2 human squamous cell carcinoma We have previously shown that stable overexpression of the thrombospondin-2 (TSP-2) gene inhibited the tumor growth and angiogenesis of human squamous cell carcinoma xenotransplants. 14675207 Human
thrombospondin-2 human squamous cell carcinoma We have previously shown that stable overexpression of the thrombospondin-2 (TSP-2) gene inhibited the tumor growth and angiogenesis of human squamous cell carcinoma xenotransplants. 14675207 Human
tsp-2 tumor We have previously shown that stable overexpression of the thrombospondin-2 (TSP-2) gene inhibited the tumor growth and angiogenesis of human squamous cell carcinoma xenotransplants. 14675207 Human
thrombospondin-2 tumor We have previously shown that stable overexpression of the thrombospondin-2 (TSP-2) gene inhibited the tumor growth and angiogenesis of human squamous cell carcinoma xenotransplants. 14675207 Human
thrombospondin 2 non-small cell lung cancer Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer. 9676856 Human
tsp2 non-small cell lung cancers We examined expression of TSP1 and TSP2 genes in 78 non-small cell lung cancers (NSCLCs) and 33 extraneoplastic lung tissue samples by reverse transcription-PCR. 9676856 Human
tsp2 adenocarcinoma Patients with adenocarcinoma positive for TSP2 gene expression (22 of 49) showed significantly better prognosis than those without TSP2 (27 of 49; Cox-Mantel test, P=0.034). 9676856 Human
thbs2 endometrial adenocarcinoma Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma. 12796396 Human
thbs2 primary cancers Frequent HOXA11 and THBS2 methylation prompted analysis of case-matched bloods and 25 additional nonrecurrent primary cancers. 12796396 Human
thbs2 tumor RESULTS: Rates of methylation in the initial tumor series were as follows: HOXA11, 70.8%; THBS2, 62.5%; MLH1, 33.3%; CTNNB1, 16.7%; VDR, 4.2%; CDKN2A, 4.2%; and THBS1, 0%. 12796396 Human
thbs2 tumors High rates of HOXA11 and THBS2 methylation were confirmed in the additional nonrecurrent tumors. 12796396 Human
tsp2 invasive breast carcinoma We found that TSP2, like TSP1, was expressed in human breast tissues, and that TSP1 and TSP2 mRNA expression in invasive breast carcinoma NOS was significantly increased compared to that observed in normal and benign tissues. 9012463 Human
tsp2 tumor The expression of TSP1 and TSP2 in invasive breast ductal carcinoma NOS did not significantly correlate with any of the prognostic factors studied (tumor size, lymph node status, morphology, and hormone receptor status). 9012463 Human
tsp2 breast ductal carcinoma The expression of TSP1 and TSP2 in invasive breast ductal carcinoma NOS did not significantly correlate with any of the prognostic factors studied (tumor size, lymph node status, morphology, and hormone receptor status). 9012463 Human
tsp2 breast carcinoma However, when our study population was divided according to the quantity of tumor stroma, TSP1 (and possibly TSP2) mRNA expression and microvessel counts in desmoplastic-rich stroma of breast carcinoma NOS were significantly increased compared to those ob 9012463 Human
tsp2 tumor However, when our study population was divided according to the quantity of tumor stroma, TSP1 (and possibly TSP2) mRNA expression and microvessel counts in desmoplastic-rich stroma of breast carcinoma NOS were significantly increased compared to those ob 9012463 Human
tsp-2 melanoma These two adhesive sites supported the attachment of a wide variety of cells (human breast carcinoma, melanoma and osteosarcoma cells), and a high degree of sequence homology was found between TSP-1 and TSP-2 between residues 60 and 94 (48% identity) and 9032471 Human
tsp-2 human breast carcinoma These two adhesive sites supported the attachment of a wide variety of cells (human breast carcinoma, melanoma and osteosarcoma cells), and a high degree of sequence homology was found between TSP-1 and TSP-2 between residues 60 and 94 (48% identity) and 9032471 Human
thrombospondin-2 salivary-gland carcinomas Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas. 12824879 Human
tsp-2 tumors The gene encoding for thrombospondin-2 (TSP-2) is located in LCR2 and 8 of 9 tumors demonstrating LOH in this region also showed significantly decreased TSP-2 expression by immunohistochemistry. 12824879 Human
thrombospondin-2 tumors The gene encoding for thrombospondin-2 (TSP-2) is located in LCR2 and 8 of 9 tumors demonstrating LOH in this region also showed significantly decreased TSP-2 expression by immunohistochemistry. 12824879 Human
tsp-2 tumors As TSP-2 is a potent inhibitor of tumor growth and angiogenesis, we examined whether TSP-2 expression correlated to microvascular angiogenesis in these tumors and discovered that microvessel counts were significantly higher in lesions with decreased TSP-2 12824879 Human
tsp-2 tumor As TSP-2 is a potent inhibitor of tumor growth and angiogenesis, we examined whether TSP-2 expression correlated to microvascular angiogenesis in these tumors and discovered that microvessel counts were significantly higher in lesions with decreased TSP-2 12824879 Human
tsp-2 cancer MATERIALS AND METHODS: The expression of TSP-1, TSP-2 and CD36 receptor was assessed in 73 tissue specimens using immunohistochemistry; specimens were from 32 patients with BPH, seven with prostatic intraepithelial neoplasia (PIN) and 34 with cancer. 15180634 Human
tsp-2 prostatic intraepithelial neoplasia (pin) MATERIALS AND METHODS: The expression of TSP-1, TSP-2 and CD36 receptor was assessed in 73 tissue specimens using immunohistochemistry; specimens were from 32 patients with BPH, seven with prostatic intraepithelial neoplasia (PIN) and 34 with cancer. 15180634 Human
thrombospondin-2 tumor Viral vector-mediated transduction of a modified thrombospondin-2 cDNA inhibits tumor growth and angiogenesis. 15103317 Mouse
thrombospondin-2 tumor We have constructed retroviral and adenoviral vectors that express murine N-terminal fragments of thrombospondin-2 (NfTSP2), a potent endogenous inhibitor of tumor growth and angiogenesis. 15103317 Human
tsp-2 cancer Conversely, overexpression of TSP-1 or TSP-2 in cancer cells results in reduced tumor vascularization and tumor growth. 12570805 Mouse
tsp-2 tumor Conversely, overexpression of TSP-1 or TSP-2 in cancer cells results in reduced tumor vascularization and tumor growth. 12570805 Mouse
thbs2 breast tumors In this study, we investigated these changes using comparative genomic hybridization and bisulfite polymerase chain reaction analysis for CpG island hypermethylation of the following genes: TP16, THBS2, E-Cadherin (ECAD), RARbeta2, MINT1, MINT2, and MINT3 14499694 Human
tsp2 embryonal carcinoma In this study, we investigated the expression of two of the TSPs--TPS1 and TSP2--during the course of differentiation of embryonal carcinoma cells in vitro. 8126073 Human
tsp2 tumor Tumor cells over-expressing tissue factor released more (compared with control transfectants) mitogenic activity for endothelial cells in parallel with enhanced transcription of vascular permeability factor/vascular endothelial cell growth factor (VEGF/VP 7521887 Mouse
thrombospondin 2 primary tumours Here, we show that thrombospondin 2, an extracellular matrix molecule which was differentially regulated in the microarray analysis, was strongly expressed in melanoma metastases, but not in primary tumours. 12353704 Human
thrombospondin 2 metastasis At the same time, MMP9, thrombospondin 2 (TSP2), etc.may play an important role in pulmonary cancer metastasis and infiltration. 14960233 Human
thrombospondin 2 ovarian carcinoma Downregulated genes in OSPC included transforming growth factor-beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family member I (ARHI), thrombospondin 2 and disabled-2/differentially expressed in ovarian carcin 15305371 Human
tsp-2 bph MATERIALS AND METHODS: The expression of TSP-1, TSP-2 and CD36 receptor was assessed in 73 tissue specimens using immunohistochemistry; specimens were from 32 patients with BPH, seven with prostatic intraepithelial neoplasia (PIN) and 34 with cancer. 15180634 Human
tsp-2 rat prostate cancer The present study was therefore designed to evaluate the expression of thrombospondin 1 and 2 (TSP-1, TSP-2), TSP receptors CD36 and CD47, and matrix-metalloproteases 2 and 9 (MMP-, MMP-9) in a rat prostate cancer model. 16076702 Rat
tsp2 nsclc TSP2 expression was significantly decreased in NSCLC as compared with extraneoplastic lung tissue (chi2 test, P=0.019). 9676856 Human
tsp2 nsclc Vascularity in the NSCLC was inversely correlated with TSP2 gene expression (Mann-Whitney U test, P=0.009). 9676856 Human
tsp2 nsclc These results suggested that TSP2 had an inhibitory role against vascularization and progression of NSCLC. 9676856 Human
tsp2 gliomas We examined TSP1, TSP2 and vascular endothelial growth factor (VEGF) gene expression by reverse transcription-polymerase chain reaction (RT-PCR) in 37 gliomas. 10448307 Human
tsp2 gliomas Seven gliomas lacked TSP2 gene expression, while the other 30 expressed TSP2. 10448307 Human
tsp-2 osteosarcoma These two adhesive sites supported the attachment of a wide variety of cells (human breast carcinoma, melanoma and osteosarcoma cells), and a high degree of sequence homology was found between TSP-1 and TSP-2 between residues 60 and 94 (48% identity) and 9032471 Human
tsp-2 squamous cell carcinoma To directly examine the biological effect of TSP-2 expression on tumor growth and angiogenesis, human A431 squamous cell carcinoma cells, which do not express TSP-2, were stably transfected with a murine TSP-2 expression vector or with vector alone. 10611308 Human
tsp-2 malignant tumor In particular, thrombospondin-1 (TSP-1) and TSP-2 are expressed in normal skin and, when introduced into squamous cell carcinomas, potently inhibit malignant tumor growth via inhibition of tumor angiogenesis. 11147670 Human
tsp-2 squamous cell carcinomas In particular, thrombospondin-1 (TSP-1) and TSP-2 are expressed in normal skin and, when introduced into squamous cell carcinomas, potently inhibit malignant tumor growth via inhibition of tumor angiogenesis. 11147670 Human
tsp-2 tumor angiogenesis In particular, thrombospondin-1 (TSP-1) and TSP-2 are expressed in normal skin and, when introduced into squamous cell carcinomas, potently inhibit malignant tumor growth via inhibition of tumor angiogenesis. 11147670 Human
tsp-2 tumors The main emphasis of this review is to discuss the role of two potent endogenous inhibitors, thrombospondin-(TSP-)1 and TSP-2, for the development and progression of tumors. 12796842 Human
tsp-2 mec Our results suggest that 6q LOH may be a significant event in salivary gland carcinogenesis, particularly in ACC and MEC, and that the correlated decrease of TSP-2 expression also plays a critical role. 12824879 Human
tsp-2 squamous cell carcinomas Daily intraperitoneal injections of TSP-2/NTF resulted in a significant inhibition of the growth of human A431 squamous cell carcinomas in vivo and in reduced tumor vascularization. 14675207 Human
tsp-2 tumor Daily intraperitoneal injections of TSP-2/NTF resulted in a significant inhibition of the growth of human A431 squamous cell carcinomas in vivo and in reduced tumor vascularization. 14675207 Human
tsp-2 tumor Moreover, TSP-2/NTF potently induced human dermal microvascular endothelial cell apoptosis in vitro but did not affect A431 tumor cell proliferation or apoptosis. 14675207 Human
tsp-2 tumor These findings identify TSP-2/NTF as a potent systemic inhibitor of tumor growth and angiogenesis, acting by direct inhibition of several endothelial cell functions involved in neovascularization. 14675207 Human
tsp2 metastasis At the same time, MMP9, thrombospondin 2 (TSP2), etc.may play an important role in pulmonary cancer metastasis and infiltration. 14960233 Human
tsp ii tumor angiogenesis The inverse association we found between TSP I and basic FGF suggests a different role of TSP I and TSP II in the angiogenic "switch," supporting the hypothesis that especially TSP I may have a significant function in tumor angiogenesis. 9918214 Human
thrombospondin-2 salivary gland carcinomas Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas. 12824879 Human
thrombospondin-2 fibrosarcoma In addition to its recognition by alpha3beta1 and alpha4beta1 integrins, the N-terminal pentraxin module of thrombospondin-1 is a ligand for alpha6beta1 integrin. alpha6beta1 integrin mediates adhesion of human microvascular endothelial and HT-1080 fibros 12909644 Human
tsp-2 tumor In infected tumors, this increased vascularity is mediated by reduced TSP-1 and TSP-2 levels and causes delayed tumor growth resumption. 17234749 Mouse
thrombospondin 2 pulmonary cancer At the same time, MMP9, thrombospondin 2 (TSP2), etc.may play an important role in pulmonary cancer metastasis and infiltration. 14960233 Human
tsp2 pulmonary cancer At the same time, MMP9, thrombospondin 2 (TSP2), etc.may play an important role in pulmonary cancer metastasis and infiltration. 14960233 Human
thrombospondin 2 tumour The present study investigated the expression in this tumour of three matricellular proteins--Secreted Protein Acidic and Rich in Cysteine (SPARC), thrombospondin 1 (TSP1) and thrombospondin 2 (TSP2)--with putative contrasting roles in the regulation of a 16314734 Human
tsp-2 skin cancer The matricellular protein, thrombospondin-2 (TSP-2), has been shown to act as an antiangiogenesis factor in a carcinogen-induced model of skin cancer. 16230396 Human
tsp-2 tumor In wild-type mice, MMP-2 was coexpressed with TSP-2 in the tumor microvasculature. 16230396 Mouse
tsp-2 gliomas Thus, the antiangiogenic activity of TSP-2 is capable of inhibiting the growth of gliomas in part by reducing the levels of MMP-2 in the tumor microvasculature. 16230396 Mouse
tsp-2 tumor Thus, the antiangiogenic activity of TSP-2 is capable of inhibiting the growth of gliomas in part by reducing the levels of MMP-2 in the tumor microvasculature. 16230396 Mouse
tsp2 tumour In general, TSP1 and TSP2 counter angiogenesis (including tumour angiogenesis) and play important but contrasting roles during cutaneous repair. 15996506 Human
tsp2 tumour Some immunopositivity for TSP2 was detected in tumour cells in approximately 40% of specimens, but was not associated with survival, tumour vascularity or any other histopathological indices of survival. 16314734 Human
thrombospondin-2 glioma Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model. 16230396 Mouse
thrombospondin-2 skin cancer The matricellular protein, thrombospondin-2 (TSP-2), has been shown to act as an antiangiogenesis factor in a carcinogen-induced model of skin cancer. 16230396 Mouse
thrombospondin-2 metastatic colorectal cancer Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. 16365183 Human
thrombospondin ii osteosarcoma The gene is transcribed in fibroblasts, smooth muscle cells, and an osteosarcoma cell line, at levels somewhat lower than that of thrombospondin I. Umbilical vein endothelial cells do not transcribe thrombospondin II under the conditions of this study. 1559694 Human
thrombospondin ii osteosarcoma The gene is transcribed in fibroblasts, smooth muscle cells, and an osteosarcoma cell line, at levels somewhat lower than that of thrombospondin I. Umbilical vein endothelial cells do not transcribe thrombospondin II under the conditions of this study. 1559694 Human
tsp-2 osteosarcoma These two adhesive sites supported the attachment of a wide variety of cells (human breast carcinoma, melanoma and osteosarcoma cells), and a high degree of sequence homology was found between TSP-1 and TSP-2 between residues 60 and 94 (48% identity) and 9032471 Human
tsp-2 tumors In infected tumors, this increased vascularity is mediated by reduced TSP-1 and TSP-2 levels and causes delayed tumor growth resumption. 17234749 Mouse
thrombospondin 2 rcc We identified a number of genes, including CXCR4, matrix metalloproteinase 9, thrombospondin 2, and vascular endothelial growth factor, that were highly expressed in RCC versus normal tissue. 11937758 Human
thrombospondin 2 basal cell carcinoma Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 squamous cell carcinoma Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 melanoma Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 tumour Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 tumours Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 vascular tumours Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
thrombospondin 2 kaposi's sarcoma Vascular quiescence in the skin seems to be primarily maintained by a balance between the endogenous angiogenesis inhibitors thrombospondin 1 and thrombospondin 2 and the potent proangiogenic factor vascular endothelial growth factor A. Inhibiting tumour 12410692 Human
tsp-2 necrosis Extensive areas of necrosis were observed in TSP-2-expressing tumors, and both the density and the size of tumor vessels were significantly reduced, although tumor cell expression of the major tumor angiogenesis factor, vascular endothelial growth factor, 10611308 Mouse
tsp-2 tumor angiogenesis Extensive areas of necrosis were observed in TSP-2-expressing tumors, and both the density and the size of tumor vessels were significantly reduced, although tumor cell expression of the major tumor angiogenesis factor, vascular endothelial growth factor, 10611308 Mouse
tsp-2 tumor Extensive areas of necrosis were observed in TSP-2-expressing tumors, and both the density and the size of tumor vessels were significantly reduced, although tumor cell expression of the major tumor angiogenesis factor, vascular endothelial growth factor, 10611308 Mouse
tsp-2 tumors Extensive areas of necrosis were observed in TSP-2-expressing tumors, and both the density and the size of tumor vessels were significantly reduced, although tumor cell expression of the major tumor angiogenesis factor, vascular endothelial growth factor, 10611308 Mouse
tsp-2 carcinogenesis To elucidate the biological role of the endogenous angiogenesis inhibitor thrombospondin-2 (TSP-2) during multistep carcinogenesis, we subjected TSP-2-deficient and wild-type mice to a chemical skin carcinogenesis regimen. 11387198 Human
tsp-2 tumorigenesis Surprisingly, TSP-2 expression was strongly upregulated in the mesenchymal stroma of wild-type mice throughout the consecutive stages of tumorigenesis whereas the angiogenesis factor, vascular endothelial growth factor, was induced predominantly in tumor 11387198 Mouse
tsp-2 carcinogenesis TSP-2 deficiency dramatically enhanced susceptibility to skin carcinogenesis and resulted in accelerated and increased tumor formation. 11387198 Mouse
tsp-2 tumor angiogenesis The angiogenic switch occurred in early stages of pre-malignant tumor formation, and tumor angiogenesis was significantly enhanced in TSP-2-deficient mice. 11387198 Mouse
tsp-2 tumor The angiogenic switch occurred in early stages of pre-malignant tumor formation, and tumor angiogenesis was significantly enhanced in TSP-2-deficient mice. 11387198 Mouse
tsp-2 tumorigenesis These results reveal upregulation of an endogenous angiogenesis inhibitor during multi step tumorigenesis and identify enhanced stromal TSP-2 expression as a novel host anti-tumor defense mechanism. 11387198 Human
tsp-2 recurrent cervical cancer Comparing gene transcript levels between recurrent and non-recurrent cervical cancer patients revealed significant differences (P=0.038) in transcript levels for the angiogenesis inhibitor TSP-2, with the highest levels in non-recurrent cases. 12189553 Human
tsp-2 carcinogenesis TSP-1-null and TSP-2-null mice display increased tissue vascularity and enhanced sensitivity to carcinogenesis. 12570805 Mouse
tsp-2 carcinogenesis Our results suggest that 6q LOH may be a significant event in salivary gland carcinogenesis, particularly in ACC and MEC, and that the correlated decrease of TSP-2 expression also plays a critical role. 12824879 Human
tsp2 oncogenes Expression of TSP1 and TSP2 is modulated by hypoxia and by oncogenes. 11530335 Human
tsp2 tumorigenesis TSP2 has recently attracted attention as an endogenous negative regulator of angiogenesis in tumorigenesis. 11788898 Human
thrombospondin-2 carcinogenesis Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. 11387198 Mouse
thrombospondin-2 carcinogenesis To elucidate the biological role of the endogenous angiogenesis inhibitor thrombospondin-2 (TSP-2) during multistep carcinogenesis, we subjected TSP-2-deficient and wild-type mice to a chemical skin carcinogenesis regimen. 11387198 Human

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