IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TK1 Ensembl ENSG00000167900 Chromosome 17 Start 73681755 End 73694909
Description Thymidine kinase, cytosolic (EC 2.7.1.21) [Source:UniProtKB/Swiss-Prot;Acc:P04183]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 11830
     Entrez Gene : 7083
     UCSC : uc002juw.2
     GeneCards : 11830
     RefSeq : NM_003258
     CCDS : CCDS11754.1
     Uniprot : P04183
     Interpro : P04183
     OMIM : 188300
     GeneTests : TK1
     CGAP : TK1

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41400_at  1.13  2.60e-11  4.34e-10  1.85  5.25e-13  1.11e-11
 HG_U95  910_at  1.91  2.59e-18  1.38e-16  2.77  2.44e-15  8.43e-14
 HG_U133A  202338_at  1.26  5.06e-30  7.86e-29  0.85  3.35e-17  4.67e-17
 HG_U133_Plus2  1554408_a_at  1.59  2.42e-28  1.38e-26  2.40  1.44e-40  3.01e-38
 HG_U133_Plus2  202338_at  1.90  1.35e-34  1.53e-32  2.76  2.22e-49  2.83e-46
 Stanford  21697  2.35  6.46e-7  1.04e-4  3.10  9.27e-10  1.20e-6
 Agilent_HS_21.6K  2571  0.39  4.61e-3  2.55e-2  0.65  5.83e-12  5.15e-10

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202338_at  0.01  9.82e-1  9.99e-1  0.23  1.89e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41400_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 910_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202338_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554408_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202338_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21697    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 2571    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tk1 tumor The usefulness of radiolabeled 3'-fluoro-3'-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. 11929696 Human
thymidine kinase 1 tumor The usefulness of radiolabeled 3'-fluoro-3'-deoxythymidine (FLT), a thymidine derivative with affinity to cytoplasmic thymidine kinase 1 (TK1), as a tumor proliferation marker was evaluated using [3H]FLT and 22 cultured tumor cell lines. 11929696 Human
tk1 tumour This suggests that the differences in the changes in the degree of phosphorylation of TK1 after irradiation among spleen, thymus and ascites tumour further underline the complexity of the response of TK1 activity to irradiation. 11952642 Human
tk1 epithelial ovarian cancer We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 69 samples from epithelial ovarian cancer, 8 low-malignant-potential tumors, 16 benign ovarian tumors and 34 normal ovaries. 11992400 Human
tk1 benign ovarian tumors We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 69 samples from epithelial ovarian cancer, 8 low-malignant-potential tumors, 16 benign ovarian tumors and 34 normal ovaries. 11992400 Human
tk1 tumors We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 69 samples from epithelial ovarian cancer, 8 low-malignant-potential tumors, 16 benign ovarian tumors and 34 normal ovaries. 11992400 Human
tk1 epithelial ovarian cancer TK1 gene expression, the ratio of TK1 to TS gene expression, that of TK1 to TP and that of TK1 to DPD were significantly higher in epithelial ovarian cancer than in normal ovaries. 11992400 Human
tk1 epithelial ovarian cancer In epithelial ovarian cancer, TK1 gene expression correlated with cytosolic and serum TK activities, TS and TP gene expression and the ratio of TP to DPD gene expression. 11992400 Human
tk1 cancer Combined analysis demonstrated that the relative risk of cancer death for tumors with high TK1, high TS and high TP gene expression was greater than that for tumors with high TK1 gene expression alone. 11992400 Human
tk1 tumors Combined analysis demonstrated that the relative risk of cancer death for tumors with high TK1, high TS and high TP gene expression was greater than that for tumors with high TK1 gene expression alone. 11992400 Human
tk1 epithelial ovarian cancer TK1 gene expression together with TS, TP and DPD gene expression may play important roles in influencing the malignant behavior of epithelial ovarian cancer. 11992400 Human
thymidine kinase 1 gastric cancer The half-life of thymidine kinase 1 in serum measured by ECL dot blot: a potential marker for monitoring the response to surgery of patients with gastric cancer. 12113581 Human
thymidine kinase 1 gastric cancer Thymidine kinase 1 in serum (STK1) of patients with gastric cancer was determined by two methods: ECL dot blot and radioactivity assay. 12113581 Human
tk-1 pancreatic cancer TK-1 and thymidine synthetase mRNA were increased in six pancreatic cancer cell lines, while mRNA levels of thymidine kinase 2 and deoxycytidine kinase were down-regulated. 12192562 Human
tk-1 human pancreatic cancer Furthermore, TK-1 was overexpressed in human pancreatic cancer as compared with normal pancreatic tissue and samples from patients with chronic pancreatitis. 12192562 Human
tk-1 pancreatic cancer TK-1, as the rate-limiting enzyme of [(18)F]FLT metabolism, is overexpressed in pancreatic cancer cell lines and in human pancreatic cancer. 12192562 Human
tk-1 human pancreatic cancer TK-1, as the rate-limiting enzyme of [(18)F]FLT metabolism, is overexpressed in pancreatic cancer cell lines and in human pancreatic cancer. 12192562 Human
thymidine kinase-1 carcinoma Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. 12215561 Human
tk1 human breast cancers To explore the expression of cytosolic thymidine kinase 1 (TK1) as a cell proliferative marker in human breast cancers, immunohistochemistry was used to detect the expression of TK1 in 52 malignant breast lesions, 20 benign breast lesions, and 16 normal b 12449723 Human
thymidine kinase 1 human breast cancers To explore the expression of cytosolic thymidine kinase 1 (TK1) as a cell proliferative marker in human breast cancers, immunohistochemistry was used to detect the expression of TK1 in 52 malignant breast lesions, 20 benign breast lesions, and 16 normal b 12449723 Human
tk1 breast carcinomas We conclude that TK1 might be a more accurate marker than PCNA for estimation of cell proliferation and malignant potentials in breast carcinomas. 12449723 Human
thymidine kinase 1 breast cancer Thymidine kinase 1 immunoassay: a potential marker for breast cancer. 11270425 Human
tki breast cancer Previous research indicates that thymidine kinase I (TKI) possesses value as a tool for both prognosis and diagnosis in breast cancer. 11270425 Human
tki human mcf-7 breast cancer To test the accuracy of this monoclonal antibody further, we treated human MCF-7 breast cancer cells with tamoxifen and measured decreasing TKI activity and protein levels with the radioassay and with our monoclonal antibody in an ELISA, respectively. 11270425 Human
tk1 breast cancer We then used the radioassay and our monoclonal antibody to measure TK1 activity and protein levels, respectively, in 218 serum samples of postoperative breast cancer patients and found a correlation between the two assays. 11270425 Human
tk1 breast cancer Our results demonstrated that the TK1 immunoassay not only had a linear, reproducible, and specific response but accurately measured TK1 levels in both MCF-7 breast cancer cells and serum. 11270425 Human
tk1 tumor Previous research has shown that thymidine kinase 1 (TK1), a nucleotide salvage pathway enzyme, is an accurate prognostic and diagnostic tumor marker. 11289224 Human
thymidine kinase 1 tumor Previous research has shown that thymidine kinase 1 (TK1), a nucleotide salvage pathway enzyme, is an accurate prognostic and diagnostic tumor marker. 11289224 Human
tk1 cancer However, the current radioisotope assay for TK1 is cumbersome and has hampered the clinical application of this diagnostic technique in cancer management. 11289224 Human
tk1 cancer Thus, in the future, these antibodies may aid in the early detection of cancer and more accurate prognosis, as well as allowing for an increased ability to study the function of TK1 in basic cellular processes. 11289224 Human
tki cancer ZD1839 (Iressa) is a p.o.-active, selective EGFR-tyrosine kinase inhibitor (TKI) in clinical trials in cancer patients. 11350918 Human
thymidine kinase 1 pancreatic cancer Thymidylate synthase was increased already in premalignant lesions, whereas thymidine kinase 1 mRNA levels were up-regulated 4-fold in the pancreatic cancer specimen of these mice. 11358795 Human
tki breast carcinoma A number of approaches are being investigated as possible therapeutic strategies that target HER2: (1) growth inhibitory antibodies, which can be used alone or in combination with standard chemotherapeutics; (2) tyrosine kinase inhibitors (TKI), which hav 10623878 Human
thymidine kinase 1 breast cancer The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. 10883887 Human
thymidine kinase-1 tumors The use of radiolabeled thymidine (TdR) and thymidine analogs as PET-based tracers of tumor growth rate is based on the assumption that measurement of uptake of these nucleosides, a function primarily of thymidine kinase-1 (TK(1)) activity, provides an ac 14660729 Human
thymidine kinase-1 tumor The use of radiolabeled thymidine (TdR) and thymidine analogs as PET-based tracers of tumor growth rate is based on the assumption that measurement of uptake of these nucleosides, a function primarily of thymidine kinase-1 (TK(1)) activity, provides an ac 14660729 Human
tk1 colorectal carcinoma Here we have presented for the first time thymidine kinase 1 (TK1) as a proliferative tumor marker for colorectal carcinoma. 11205225 Human
thymidine kinase 1 colorectal carcinoma Here we have presented for the first time thymidine kinase 1 (TK1) as a proliferative tumor marker for colorectal carcinoma. 11205225 Human
tk1 tumor Here we have presented for the first time thymidine kinase 1 (TK1) as a proliferative tumor marker for colorectal carcinoma. 11205225 Human
thymidine kinase 1 tumor Here we have presented for the first time thymidine kinase 1 (TK1) as a proliferative tumor marker for colorectal carcinoma. 11205225 Human
tk1 colorectal adenoma PATIENTS AND METHODS: Expression of TK1 in 54 colorectal lesions and 20 colorectal adenoma lesions was detected by immunohistochemistry technique (ABC). 11205225 Human
tk1 colorectal adenoma TK1-LI as well as PCNA-LI showed significant differences between colorectal carcinoma and colorectal adenoma (TK1 p = 0.0005, PCNA p = 0.0005). 11205225 Human
tk1 colorectal carcinoma TK1-LI as well as PCNA-LI showed significant differences between colorectal carcinoma and colorectal adenoma (TK1 p = 0.0005, PCNA p = 0.0005). 11205225 Human
tk1 tumor Both TK1-LI and PCNA were significantly different in respect to tumor stages (TK1 p = 0.0002, PCNA p = 0.0284). 11205225 Human
tk 1 acute myelocytic leukemia (aml) The dominating thymidine kinase activity in mononuclear white blood cells from three patients with untreated acute myelocytic leukemia (AML) was compared with TK 1 from phytohemagglutinin-stimulated and TK 2 from unstimulated, normal lymphocytes. 3162755 Human
tk1 breast cancer Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. 3408646 Human
tk1 breast cancer The increase in serum TK from breast cancer patients appears to be due to an increase in both TK1 and TK2 levels. 3408646 Human
tk1 acute-lymphocytic leukemia (all) The activity of thymidine kinase (TK) and the proportion of its isozymes (TK1/TK2) were studied in peripheral lymphoid cells of 37 children with acute lymphocytic leukemia (ALL). 3469483 Human
tk-1 lymphoma Here we report that an activator (AIF4-) of heterotrimeric GTP-binding proteins (G-proteins) and inhibitors (lovastatin and C3 exoenzyme) of small GTP-binding proteins regulate the induction of alpha4beta7-mediated adhesion of TK-1 T lymphoma cells (alpha 10508262 Human
tk1 mouse lymphoma The thymidine kinase locus (Tk1) in Tk(+/-)-3.7.2C mouse lymphoma cells is widely used to identify mutagenic agents. 9800187 Human
tk1 mouse lymphoma Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents, we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53 9800187 Human
thymidine kinase 1 tumors We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in 9809561 Human
thymidine kinase 1 colorectal cancer Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer. 12699056 Human
thymidine kinase 1 solid tumors We report the first mutational study of thymidine kinase 1 (TK1) performed in human solid tumors. 12699056 Human
tk1 cancer We sequenced cDNAs representing the complete coding region of TK1 in human breast (n=22) and colorectal (n=26) cancer. 12699056 Human
tk1 tumor This may open new avenues that imply TK1 activity in tumor cell proliferation. 12699056 Human
tk1 breast tumors FISH localization of the soluble thymidine kinase gene (TK1) to human 17q25, a region of chromosomal loss in sporadic breast tumors. 8641139 Human
tk1 breast tumors Through somatic cell hybrid and fluorescence in situ hybridization studies, we mapped TK1 to 17q25.2-->25.3, in region demonstrating loss of heterozygosity in primary breast tumors. 8641139 Human
thymidine kinase-1 tumor Mus domesticus DNA probes for the tumor suppressor protein-53 (Tp53) and thymidine kinase-1 (Tk1) genetic loci were used to identify clones representing these loci in a Peromyscus leucopus (white-footed mouse) cosmid library. 7835097 Human
tk1 tumor Mus domesticus DNA probes for the tumor suppressor protein-53 (Tp53) and thymidine kinase-1 (Tk1) genetic loci were used to identify clones representing these loci in a Peromyscus leucopus (white-footed mouse) cosmid library. 7835097 Human
tk1 acute lymphoblastic leukaemia TK1 isoenzyme activity was highest in acute lymphoblastic leukaemia and in centroblastic lymphoma. 6536100 Human
tk1 centroblastic lymphoma TK1 isoenzyme activity was highest in acute lymphoblastic leukaemia and in centroblastic lymphoma. 6536100 Human
tk1 hairy-cell leukaemia Fetal thymidine kinase (TK1) in hairy cell leukaemia. 6836228 Human
tk1 lymphoma LPAM expressed by TK1 (Peyer's patch HEV-binding murine lymphoma) and MEL-14 R expressed by 38C13 (peripheral lymph node HEV-binding murine lymphoma) were found to be regulated by the consequences of PMA activation in a pattern similar to that of nor 2088474 Human
tk1 chronic lymphatic leukemia (cll) The level of cytosolic thymidine kinase (TK1) mRNA in lymphocytes from six healthy people and in lymphocytes from five patients with untreated chronic lymphatic leukemia (CLL) was determined with competitive polymerase chain reaction (competitive PCR). 7967713 Human
tk-1 mouse lymphoma The mouse lymphoma (L5178Y tk+/- 3.7.2C) in vitro mutagenesis assay can measure the genotoxic effects of a wide variety of chemical agents by inactivation of a single functional thymidine kinase (tk-1) gene. 7837976 Human
tk-1 tumor We have previously demonstrated, using cytogenetic and molecular techniques, that the types of molecular lesions associated with tk-1 gene inactivation span a wide range similar to that seen in tumor cells at specific oncogene and tumor suppressor gene lo 7837976 Human
tk1 chronic lymphatic leukemia Quantitation of TK1 mRNA in patients with chronic lymphatic leukemia. 7660896 Human
tk-1 tumors Immunostaining confirmed high levels of TK-1 in DoHH2 derived xenograft tumors in SCID/SCID mice. 12750297 Human
tk1 retinoblastoma The genes for SOD1 and SOD2 (superoxide dismutases 1 and 2), RB1 (retinoblastoma), TYMS (thymidylate synthase), and TK1 (thymidine kinase) were mapped by in situ hybridization using biotinylated probes to rabbit chromosomes 6, 12, 8, 9, and 19, respective 1395722 Human
tk1 tumors RESULTS: Total TK (TK1 plus TK2) levels in tumors were significantly (P < .001) elevated in patients who subsequently had recurrence compared with levels in those who did not. 1433372 Human
tk1 tumor ER- patients with recurrence had significantly (P < .001) elevated total tumor TK levels compared with levels in those who did not have recurrence, and calculation of percent of TK activity with ATP or CTP indicated elevated TK1 levels. 1433372 Human
tk1 tumor A similar pattern of increased levels of total tumor TK and TK1 was observed in ER+ patients with recurrence. 1433372 Human
tk1 tumors IMPLICATIONS: Higher TK1 levels in tumors in patients who subsequently had disease recurrence almost certainly indicate a high rate of proliferation in such tumors at the time of excision. 1433372 Human
tk1 breast cancer With measurement of levels of TK, particularly TK1, in breast tumors and serum, it may be possible to predict recurrence of breast cancer. 1433372 Human
tk1 breast tumors With measurement of levels of TK, particularly TK1, in breast tumors and serum, it may be possible to predict recurrence of breast cancer. 1433372 Human
tk1 thyroid carcinomas Immunohistostaining of tissues in the 11 advanced-stage cancer patients (four breast carcinomas, three hepatocarcinomas and four thyroid carcinomas) indicated that a strong staining of TK1 enzyme was found in the cytoplasm of malignant cells. 12799048 Human
tk1 cancer Immunohistostaining of tissues in the 11 advanced-stage cancer patients (four breast carcinomas, three hepatocarcinomas and four thyroid carcinomas) indicated that a strong staining of TK1 enzyme was found in the cytoplasm of malignant cells. 12799048 Human
tk1 breast carcinomas Immunohistostaining of tissues in the 11 advanced-stage cancer patients (four breast carcinomas, three hepatocarcinomas and four thyroid carcinomas) indicated that a strong staining of TK1 enzyme was found in the cytoplasm of malignant cells. 12799048 Human
tk1 tumour These patients also exhibited higher total TK levels per mg tumour (P < 0.01) and higher TK1 levels (P < 0.001) than those who did not show recurrence. 1339926 Human
tk1 tumours TK1 levels relative to TK2 were significantly higher (P < 0.05) in OR-negative tumours (n = 29) than in OR-positive tumours (n = 57). 1339926 Human
tk1 tumor Tumor levels of TK1 protein and cofactor (ATP) were determined by Western blotting and bioluminescence, respectively. 12839975 Human
tk1 lymphosarcoma TK1 activity occurred in solid, non-Hodgkin's lymphoma tissue, exhibiting lesser degrees of cellular differentiation, or in peripheral blood lymphocytes of patients with clinical aggressive chronic lymphocytic leukemia or lymphosarcoma leukemia. 7448815 Human
tk1 chronic lymphocytic leukemia TK1 activity occurred in solid, non-Hodgkin's lymphoma tissue, exhibiting lesser degrees of cellular differentiation, or in peripheral blood lymphocytes of patients with clinical aggressive chronic lymphocytic leukemia or lymphosarcoma leukemia. 7448815 Human
tk1 non-hodgkin's lymphoma TK1 activity occurred in solid, non-Hodgkin's lymphoma tissue, exhibiting lesser degrees of cellular differentiation, or in peripheral blood lymphocytes of patients with clinical aggressive chronic lymphocytic leukemia or lymphosarcoma leukemia. 7448815 Human
tk1 leukemia TK1 activity occurred in solid, non-Hodgkin's lymphoma tissue, exhibiting lesser degrees of cellular differentiation, or in peripheral blood lymphocytes of patients with clinical aggressive chronic lymphocytic leukemia or lymphosarcoma leukemia. 7448815 Human
tk1 diffuse poorly-differentiated lymphocytic lymphoma In non-Hodgkin's lymphoma tissue, the range of TK1 activities correlated broadly with the Rappaport classification, with higher values occurring in tissue exhibiting changes of diffuse poorly differentiated lymphocytic lymphoma or diffuse histiocytic 7448815 Human
tk1 non-hodgkin's lymphoma In non-Hodgkin's lymphoma tissue, the range of TK1 activities correlated broadly with the Rappaport classification, with higher values occurring in tissue exhibiting changes of diffuse poorly differentiated lymphocytic lymphoma or diffuse histiocytic 7448815 Human
tk1 diffuse histiocytic lymphoma In non-Hodgkin's lymphoma tissue, the range of TK1 activities correlated broadly with the Rappaport classification, with higher values occurring in tissue exhibiting changes of diffuse poorly differentiated lymphocytic lymphoma or diffuse histiocytic 7448815 Human
tk1 non-hodgkin's lymphoma To determine whether kinase (TK) isozyme status adds clinically useful information in adult non-Hodgkin's lymphoma (NHL), we have analyzed peripheral blood plasma and lymphocytes of 44 patients with NHL for either TK1 or TK2 isozyme activity. 7296003 Human
the tk1 mrna cll The TK1 mRNA level is approximately 100-fold higher in lymphocytes from CLL patients than in lymphocytes from healthy persons. 7967713 Human
tk1 aml The levels of TdT, AdA, 5'-N, 20 alpha-SDH and TK1 were analyzed in different FAB subgroups of AML. 3006221 Human
tk1 cll Using this procedure we have shown that in patients with CLL, there is an overexpression of TK1 mRNA without corresponding enzymatic activity. 7967713 Human
tk1 cm Canine loci, GALK1, TK1, GH1, MYL4, THRA1, and RARA constitute a closely linked group near the centromeric end of CFA9, spanning a genetic distance of only 4.7 cM. 9177778 Human
tk1 cll The demonstration of TK1 activity in the peripheral blood lymphocytes of clinically aggressive CLL suggests that this isoenzyme may be a useful biochemical marker of such behaviour. 7295590 Human
tk1 adult non-hodgkin's lymphoma To determine whether kinase (TK) isozyme status adds clinically useful information in adult non-Hodgkin's lymphoma (NHL), we have analyzed peripheral blood plasma and lymphocytes of 44 patients with NHL for either TK1 or TK2 isozyme activity. 7296003 Human
tk1 solid tumors We report the first mutational study of thymidine kinase 1 (TK1) performed in human solid tumors. 12699056 Human
tk1 tumor BACKGROUND: Thymidine kinase 1 (TK1) is a cytoplasmic enzyme, produced only in the S-phase of proliferating cells, that has potential as a tumor marker. 15247154 Human
tk1 tumor Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine kinase 1 (TK1), an enzyme that is selectively expressed in a variety of rapidly proliferating cells, including tumor cells. 15342416 Human
tk1 tumour Thymidine kinase 1 (TK1), an enzyme involved in the synthesis of precursors for DNA, and thus proliferation dependent, has been suggested as a good tumour marker. 15375544 Human
tk1 cancer We have recently developed poly/monoclonal antibodies against TK1, which proved useful for diagnostics in both serum and immunohistochemistry of cancer patients. 15375544 Human
tk1 tumours Combination of TK1 mAbs 1D11 and 1E3 increased this number to 56%, due to detection of a significantly higher number of patients with grade 2 tumours. 15375544 Human
tk1 tumours Patients with stage II and grade 2 tumours showed significantly higher TK1 staining when compared to stage I and grade 1. 15375544 Human
tk1 tumours The tumours only stained for TK1 represented higher stages and grades, while tumours staining only for Ki-67 were of lower stages and grades. 15375544 Human
tk1 tumours Combining TK1 and Ki-67 increased the number of patients with positively stained tumours to 69%. 15375544 Human
tk1 tumours In conclusion, TK1 is a reliable marker for identification of patients with grade 2 tumours. 15375544 Human
tk1 tumours The highest number of patients with positively stained tumours were obtained when both TK1 and Ki-67 markers were used. 15375544 Human
tk1 cancer diseases These Abs are useful for both serological and immunohistochemical detection of TK1 in a number of cancer diseases. 15583816 Human
tk1 non-small cell lung cancer In this study we examined TK1 concentration in serum (STK1) in 250 preoperative non-small cell lung cancer patients (NSCLC), including 188 non-metastatic (group M0) and 62 metastatic patients (group M1). 15583816 Human
tk1 nsclc In this study we examined TK1 concentration in serum (STK1) in 250 preoperative non-small cell lung cancer patients (NSCLC), including 188 non-metastatic (group M0) and 62 metastatic patients (group M1). 15583816 Human
tk1 tumours PURPOSE: The aim of this study was to investigate the role of thymidine kinase 1 (TK1) protein in 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) positron emission tomography (PET) studies.METHODS: We investigated the in vivo kinetics of [18F]FLT in 15791434 Human
tk1 mouse lymphoma PURPOSE: The aim of this study was to investigate the role of thymidine kinase 1 (TK1) protein in 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) positron emission tomography (PET) studies.METHODS: We investigated the in vivo kinetics of [18F]FLT in 15791434 Human
tk1 tumours The observed differences between the cell lines with respect to [18F]FLT uptake were in keeping with a 48% higher TK1 protein in the TK1+/- tumours versus the -/- variant (P=0.043). 15791434 Human
tk1 cancer Antibodies against TK1 have provided attractive tools for cancer diagnosis. 15809747 Human
tk1 squamous cell carcinoma (scc) Expression of TK1 in 158 non-small cell lung cancer (NSCLC) patients with 59 adenocarcinoma (AC) and 99 squamous cell carcinoma (SCC) was determined by anti-TK1 monoclonal antibody (mAb) 1E3 (AC, n=50; SCC, n=70). 15809747 Human
tk1 non-small cell lung cancer Expression of TK1 in 158 non-small cell lung cancer (NSCLC) patients with 59 adenocarcinoma (AC) and 99 squamous cell carcinoma (SCC) was determined by anti-TK1 monoclonal antibody (mAb) 1E3 (AC, n=50; SCC, n=70). 15809747 Human
tk1 adenocarcinoma Expression of TK1 in 158 non-small cell lung cancer (NSCLC) patients with 59 adenocarcinoma (AC) and 99 squamous cell carcinoma (SCC) was determined by anti-TK1 monoclonal antibody (mAb) 1E3 (AC, n=50; SCC, n=70). 15809747 Human
tk1 nsclc Expression of TK1 in 158 non-small cell lung cancer (NSCLC) patients with 59 adenocarcinoma (AC) and 99 squamous cell carcinoma (SCC) was determined by anti-TK1 monoclonal antibody (mAb) 1E3 (AC, n=50; SCC, n=70). 15809747 Human
tk1 tumor Parallel tumor sections were stained for Ki-67 (MIB-1), and TK1 expression was also investigated with anti-TK1 chicken IgY Ab (AC, n=9; SCC, n=29; normal lung tissues, n=10). 15809747 Human
tk1 tumor This difference was due to a significantly higher TK1 LI of tumor stage II and grade 2. 15809747 Human
tk1 tumor Although no difference in the LI of TK1 and Ki-67 of SCC patients was found (54 vs. 53%), significantly higher TK1 LI of SCC patients of tumor grade 1 was found. 15809747 Human
tk1 tumor Samples stained only for TK1 represented mostly tumor stages I and II and grades 1 and 2 of both AC and SCC. 15809747 Human
tk1 tumor For 11 of these same genes (FPGS, DHFR, GGH, NME1, NME2, RRM2, UMPH2, UNG, UMPS, TP53, and TK1), a significant proportion of the patients showed an over expression of the particular gene in tumor tissue with a tumor-to-nonmalignant (T/N) ratio >1.2, where 15814641 Human
tk1 papillary thyroid carcinoma (ptc) The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary th 15978330 Human
tk1 tumour Oesophageal mucosal epithelial cells are derived from the epithelial cell germ layer, which expresses the kallikrein-kinin cascade.AIM: To determine the cellular distribution of active TK1, prokallikrein, and the kinin B(1) and B(2) receptors in oesophage 16126870 Human
tk1 oesophageal carcinoma AIM: To determine the cellular distribution of active TK1, prokallikrein, and the kinin B(1) and B(2) receptors in oesophageal carcinoma by immunocytochemistry and in situ hybridisation (ISH). 16126870 Human
tk1 tumour RESULTS: TK1 (active and prokallikrein) was expressed in the mucosa of normal and tumour oesophageal epithelium. 16126870 Human
tk1 oesophageal carcinoma Specific antibodies were used to determine the cellular localisation of TK1, prokallikrein, and the kinin B(1) and B(2) receptors in normal and oesophageal specimens by standard immunohistochemical techniques. 16126870 Human
tk1 oesophageal carcinoma CONCLUSIONS: This is the first demonstration that TK1 and kinin B(1) and B(2) receptors are expressed in oesophageal carcinoma. 16126870 Human
tk1 tumour Because TK1 released from tumour cells enzymatically generates mitogenic kinins from its endogenous substrate, kininogen, it is possible that third generation kinin receptor antagonists, which have been shown to be cytotoxic to cancer cells, may be useful 16126870 Human
tk1 cancer Because TK1 released from tumour cells enzymatically generates mitogenic kinins from its endogenous substrate, kininogen, it is possible that third generation kinin receptor antagonists, which have been shown to be cytotoxic to cancer cells, may be useful 16126870 Human
tk2 acute-lymphocytic leukemia (all) The activity of thymidine kinase (TK) and the proportion of its isozymes (TK1/TK2) were studied in peripheral lymphoid cells of 37 children with acute lymphocytic leukemia (ALL). 3469483 Human
tk2 breast cancer Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. 3408646 Human
tk2 breast cancer The increase in serum TK from breast cancer patients appears to be due to an increase in both TK1 and TK2 levels. 3408646 Human
tk2 tumors RESULTS: Total TK (TK1 plus TK2) levels in tumors were significantly (P < .001) elevated in patients who subsequently had recurrence compared with levels in those who did not. 1433372 Human
tk2 tumours TK1 levels relative to TK2 were significantly higher (P < 0.05) in OR-negative tumours (n = 29) than in OR-positive tumours (n = 57). 1339926 Human
tk2 cll We examined the ratio of the dcyd phosphorylation carried out by dCK and by TK2 (dCK/TK2-dcyd) in lymphocytes from CLL patients and from donors. 7637389 Human
tk2 chronic lymphocytic leukemia TK2 activity occurred in peripheral blood lymphocytes of normal individuals, patients with chronic lymphocytic leukemia, or solid lymphoid tissue, exhibiting either nonneoplastic histological findings or those of diffuse well-differentiated lymphocytic ly 7448815 Human
tk2 diffuse well-differentiated lymphocytic lymphoma TK2 activity occurred in peripheral blood lymphocytes of normal individuals, patients with chronic lymphocytic leukemia, or solid lymphoid tissue, exhibiting either nonneoplastic histological findings or those of diffuse well-differentiated lymphocytic ly 7448815 Human
tk2 adult non-hodgkin's lymphoma To determine whether kinase (TK) isozyme status adds clinically useful information in adult non-Hodgkin's lymphoma (NHL), we have analyzed peripheral blood plasma and lymphocytes of 44 patients with NHL for either TK1 or TK2 isozyme activity. 7296003 Human
tk2 acute myeloid leukemia Gain-of-function mutations in the second intracellular kinase domain (TK2) and in the juxtamembrane domain are described in patients with core binding factor acute myeloid leukemia (CBFL) and are associated with leukocytosis. 15339674 Human
thymidine kinase-1 tumors The use of thymidine (TdR) and thymidine analogs such as 3'-deoxy-3'-fluorothymidine (FLT) as positron emission tomography (PET)-based tracers of tumor proliferation rate is based on the hypothesis that measurement of uptake of these nucleosides 15093811 Human
thymidine kinase-1 tumor The use of thymidine (TdR) and thymidine analogs such as 3'-deoxy-3'-fluorothymidine (FLT) as positron emission tomography (PET)-based tracers of tumor proliferation rate is based on the hypothesis that measurement of uptake of these nucleosides 15093811 Human
thymidine kinase-1 rat glioma To compare compounds with high and low thymidine kinase-1 substrate activity, N5 and N7 and the corresponding dihydroxypropyl derivatives were selected for evaluation of their cellular toxicity, uptake and retention by the F98 rat glioma, human MRA melano 15342417 Human
thymidine kinase-1 melanoma To compare compounds with high and low thymidine kinase-1 substrate activity, N5 and N7 and the corresponding dihydroxypropyl derivatives were selected for evaluation of their cellular toxicity, uptake and retention by the F98 rat glioma, human MRA melano 15342417 Human
thymidine kinase 1 tumor BACKGROUND: Thymidine kinase 1 (TK1) is a cytoplasmic enzyme, produced only in the S-phase of proliferating cells, that has potential as a tumor marker. 15247154 Human
thymidine kinase 1 tumor Thymidine analogs containing o-carboranylalkyl groups at the 3-position were screened as potential substrates for human thymidine kinase 1 (TK1), an enzyme that is selectively expressed in a variety of rapidly proliferating cells, including tumor cells. 15342416 Human
thymidine kinase 1 tumour Thymidine kinase 1 (TK1), an enzyme involved in the synthesis of precursors for DNA, and thus proliferation dependent, has been suggested as a good tumour marker. 15375544 Human
thymidine kinase 1 non-small cell lung cancer Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. 15583816 Human
thymidine kinase 1 tumours The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels. 15791434 Human
thymidine kinase 1 tumours PURPOSE: The aim of this study was to investigate the role of thymidine kinase 1 (TK1) protein in 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) positron emission tomography (PET) studies.METHODS: We investigated the in vivo kinetics of [18F]FLT in 15791434 Human
thymidine kinase 1 mouse lymphoma PURPOSE: The aim of this study was to investigate the role of thymidine kinase 1 (TK1) protein in 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) positron emission tomography (PET) studies.METHODS: We investigated the in vivo kinetics of [18F]FLT in 15791434 Human
thymidine kinase 1 papillary thyroid carcinoma (ptc) The aim of the present study was to estimate the expression of mRNA, specific for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase), i.e. enzymes involved in pyrimidine and purine metabolism in human papillary th 15978330 Human
thymidine kinase 1 solid tumors Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. 16142366 Human
thymidine kinase 1 leukaemia Activity of thymidine kinase 1 in serum (STK) is a useful marker for leukaemia and lymphoma, but not for solid tumors. 16142366 Human
thymidine kinase 1 lymphoma Activity of thymidine kinase 1 in serum (STK) is a useful marker for leukaemia and lymphoma, but not for solid tumors. 16142366 Human
thymidine kinase 1 solid tumors Activity of thymidine kinase 1 in serum (STK) is a useful marker for leukaemia and lymphoma, but not for solid tumors. 16142366 Human
thymidine kinase 1 tumor We investigate thymidine kinase 1 concentration in serum (S-TK1) as a potential tumor marker. 16142366 Human
tk 1 aml Regarding the combined thymidine and dTTP kinetics, the enzymes from the three AML patients resembled TK 1, but the ATP kinetics were different and the molecular weights were lower, as previously found for thymidine kinases from other leukemic cells. 3162755 Human

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