IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TLE2 Ensembl ENSG00000065717 Chromosome 19 Start 2948637 End 2980022
Description Transducin-like enhancer protein 2 (ESG2) [Source:UniProtKB/Swiss-Prot;Acc:Q04725]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11838
     Entrez Gene : 7089
     UCSC : uc002lww.2
     GeneCards : 11838
     RefSeq : NM_001144761
     CCDS : CCDS45911.1
     Uniprot : Q04725
     Interpro : Q04725
     OMIM : 601041
     GeneTests : TLE2
     CGAP : TLE2
     PMID : 8808280

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40837_at  -0.16  1.30e-1  2.05e-1  -0.98  6.52e-11  9.09e-10
 HG_U133A  204431_at  -0.19  3.18e-2  4.58e-2  -1.10  6.58e-37  1.22e-36
 HG_U133A  40837_at  -0.44  1.45e-7  4.08e-7  -4.42  1.12e-86  5.38e-86
 HG_U133_Plus2  204431_at  -0.28  4.44e-2  7.60e-2  -1.21  3.08e-9  1.24e-8
 HG_U133_Plus2  40837_at  -0.12  3.53e-1  4.42e-1  -1.02  9.99e-10  4.27e-9
 Stanford  17158  -0.06  8.85e-1  9.38e-1  -1.54  3.28e-5  1.24e-3
 Agilent_HS_21.6K  12979  -0.38  7.30e-6  1.34e-4  -0.68  4.55e-12  4.14e-10

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204431_at  -0.26  3.76e-1  8.96e-1  -0.17  5.35e-1  1.00e+0
 HG_U133A  40837_at  -0.19  3.34e-1  8.87e-1  -0.14  4.04e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204431_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 40837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204431_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 40837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17158    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12979    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tle2 synovial sarcomas Finally, we also noted differential overexpression of several neural- or neuroectodermal-associated genes in synovial sarcomas relative to the comparison sarcoma group, including OLFM1, TLE2, CNTNAP1, and DRPLA. 12414507 Human
tle2 sarcoma Finally, we also noted differential overexpression of several neural- or neuroectodermal-associated genes in synovial sarcomas relative to the comparison sarcoma group, including OLFM1, TLE2, CNTNAP1, and DRPLA. 12414507 Human
tle2 meningiomas We have shown that the transcript and protein levels of HES1, the Notch2 and Notch1 receptors and the Jagged1 ligand are induced in meningiomas of all grades, whereas induction of TLE2 and TLE3 occurs specifically in higher-grade meningiomas. 15958550 Human

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