IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TOPBP1 Ensembl ENSG00000163781 Chromosome 3 Start 134802140 End 134863380
Description DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1)(DNA topoisomerase IIbeta-binding protein 1)(TopBP1) [Source:UniProtKB/Swiss-Prot;Acc:Q92547]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17008
     Entrez Gene : 11073
     UCSC : uc003eps.2
     GeneCards : 17008
     RefSeq : NM_007027
     CCDS : CCDS46919.1
     Uniprot : Q92547
     Interpro : Q92547
     OMIM : 607760
     GeneTests : TOPBP1
     CGAP : TOPBP1
     PMID : 9461304

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38834_at  0.40  2.87e-3  7.96e-3  1.15  7.78e-10  8.75e-9
 HG_U133A  202633_at  0.31  1.19e-5  2.74e-5  1.31  1.19e-69  3.83e-69
 HG_U133_Plus2  202633_at  0.26  1.26e-3  3.20e-3  0.67  2.78e-12  1.60e-11
 Stanford  2289  1.18  9.59e-4  1.42e-2  1.78  7.51e-5  2.21e-3
 Agilent_HS_21.6K  20146  0.27  1.44e-3  1.02e-2  0.50  7.69e-8  1.74e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202633_at  0.08  7.21e-1  9.72e-1  0.30  9.27e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38834_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202633_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202633_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2289    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20146    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
topbp1 colon cancer Although E2F1 was stabilized by ultraviolet (UV) irradiation, the mRNA expression level of TopBP1 was suppressed in HCT116 human diploid colon cancer cells. 15195143 Human
topbp1 breast and ovarian cancer Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer. 16930991 Human
topbp1 ovarian cancer Based on its biological significance, we reasoned that TopBP1 is a plausible susceptibility gene for hereditary breast and/or ovarian cancer and therefore screened affected index cases from 125 Finnish cancer families for germline changes by conformation 16930991 Human
topbp1 cancer Based on its biological significance, we reasoned that TopBP1 is a plausible susceptibility gene for hereditary breast and/or ovarian cancer and therefore screened affected index cases from 125 Finnish cancer families for germline changes by conformation 16930991 Human
topbp1 familial cancer This is the first study reporting mutation screening of the TopBP1 gene in a familial cancer material. 16930991 Human
topbp1 breast tumours In addition, DNA topoisomerase II binding protein 1 (TopBP1) and mismatch repair proteins 2 and 6 (MSH2 and MSH6) were immunostained in a series of 80 stage I invasive breast tumours, 26 in situ breast carcinomas and 12 benign breast hyperplasias. 16996262 NA
topbp1 breast hyperplasias In addition, DNA topoisomerase II binding protein 1 (TopBP1) and mismatch repair proteins 2 and 6 (MSH2 and MSH6) were immunostained in a series of 80 stage I invasive breast tumours, 26 in situ breast carcinomas and 12 benign breast hyperplasias. 16996262 NA
topbp1 fibroadenomatous hyperplasia The immunohistochemical expression of topoisomerase IIbeta binding protein 1 (TopBP1) was examined in 123 feline mammary lesions (18 non-neoplastic lesions including six fibroadenomatous hyperplasia and 12 duct ectasia, 17 adenomas and 88 carcinomas) in r 17336111 Human
topbp1 breast cancer Aberrant expression of TopBP1 in breast cancer. 17448016 Human
topbp1 breast cancer The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer. 17448016 Human
topbp1 breast carcinomas METHODS AND RESULTS: Sixty-one breast carcinomas from an unselected consecutive patient cohort were studied along with 12 samples of breast tissue from cosmetic breast reduction surgery; these were analysed immunohistochemically for TopBP1 expression usin 17448016 Human
topbp1 tumours However, in a significant number of breast carcinomas TopBP1 was aberrantly expressed, as it was detected in the cytoplasm and nucleus of some tumours and exclusively in the cytoplasm of others. 17448016 Human
topbp1 breast carcinomas However, in a significant number of breast carcinomas TopBP1 was aberrantly expressed, as it was detected in the cytoplasm and nucleus of some tumours and exclusively in the cytoplasm of others. 17448016 Human
topbp1 carcinomas In two out of 61 carcinomas investigated, no TopBP1 expression was detected. 17448016 Human
topbp1 breast carcinoma CONCLUSIONS: For the first time this report demonstrates aberrant expression of the TopBP1 protein in breast carcinoma. 17448016 Human
topbp1 breast cancer We propose TOPBP1 as a breast cancer susceptibility gene. 17448016 Human
topbp1 neoplasia Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53. 17336111 Human
topbp1 adenomas The immunohistochemical expression of topoisomerase IIbeta binding protein 1 (TopBP1) was examined in 123 feline mammary lesions (18 non-neoplastic lesions including six fibroadenomatous hyperplasia and 12 duct ectasia, 17 adenomas and 88 carcinomas) in r 17336111 Human
topbp1 carcinomas The immunohistochemical expression of topoisomerase IIbeta binding protein 1 (TopBP1) was examined in 123 feline mammary lesions (18 non-neoplastic lesions including six fibroadenomatous hyperplasia and 12 duct ectasia, 17 adenomas and 88 carcinomas) in r 17336111 Human
topbp1 mammary tumours TopBP1 is expressed in feline mammary tumours and its expression is correlated with histological grade. 17336111 others
topbp1 neoplasms Many neoplasms which over-express p53 or are ERalpha negative show TopBP1 immunoreactivity. 17336111 others
topbp1 breastcancer TopBP1 (topoisomerase IIbeta-binding protein 1) is a BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminal]-domain-rich protein that is structurally and functionally conserved throughout eukaryotic organisms. 17887956 Human
topbp1 cancer Over 50% of the genes identified in this screen have putative human homologs, including CHEK2, ERCC4, and TOPBP1, which are already associated with inherited cancer susceptibility. 18245329 Human

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