IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene UBE2C Ensembl ENSG00000175063 Chromosome 20 Start 43874662 End 43879003
Description Ubiquitin-conjugating enzyme E2 C (EC 6.3.2.19)(Ubiquitin-protein ligase C)(Ubiquitin carrier protein C)(UbcH10) [Source:UniProtKB/Swiss-Prot;Acc:O00762]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 15937
     Entrez Gene : 11065
     UCSC : uc002xpm.2
     GeneCards : 15937
     RefSeq : NM_007019
     CCDS : CCDS13370.1
     Uniprot : O00762
     Interpro : O00762
     OMIM : 605574
     GeneTests : UBE2C
     CGAP : UBE2C
     PMID : 9122200

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up - IHCOverall survival(P=0.0208) 19638491 Cancer Prev Res (Phila). 2009 Aug;2(8):702-11.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1651_at  3.29  2.56e-18  1.37e-16  4.36  1.86e-17  9.81e-16
 HG_U133A  202954_at  1.42  1.24e-29  1.88e-28  -0.90  8.15e-24  1.25e-23
 HG_U133_Plus2  202954_at  2.55  5.56e-44  1.88e-41  3.28  4.53e-55  2.75e-51
 Stanford  17410  2.53  2.85e-5  1.45e-3  3.10  8.24e-9  3.83e-6
 Agilent_HS_21.6K  21118  0.24  8.82e-5  1.09e-3  0.34  4.04e-6  5.16e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202954_at  0.50  1.84e-1  8.23e-1  0.23  1.89e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1651_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202954_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202954_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17410    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21118    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ubch10 primary tumors Intriguingly, UbcH10 was expressed at high levels in primary tumors derived from the lung, stomach, uterus, and bladder as compared with their corresponding normal tissues, suggesting that UbcH10 is involved in tumorigenesis or progression of the tumor. 12874022 Human
ubch10 tumor Intriguingly, UbcH10 was expressed at high levels in primary tumors derived from the lung, stomach, uterus, and bladder as compared with their corresponding normal tissues, suggesting that UbcH10 is involved in tumorigenesis or progression of the tumor. 12874022 Human
ubch10 tumor To further investigate a possible contribution of UbcH10 to malignant transformation and tumor cell proliferation, NIH3T3 cells were transfected with the expression plasmid encoding UbcH10, and stable transfectants were subsequently established. 12874022 Human
ubch10 primary tumors Collectively, our present results provide the first evidence that UbcH10 is highly expressed in various human primary tumors and that UbcH10 has an ability to promote cell growth and malignant transformation. 12874022 Human

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