IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene VAV2 Ensembl ENSG00000160293 Chromosome 9 Start 135616837 End 135847547
Description Guanine nucleotide exchange factor VAV2 (VAV-2) [Source:UniProtKB/Swiss-Prot;Acc:P52735]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12658
     Entrez Gene : 7410
     UCSC : uc004ces.2
     GeneCards : 12658
     RefSeq : NM_001134398
     CCDS : CCDS6979.1
     Uniprot : Q6PIJ9
     Interpro : Q6PIJ9
     OMIM : 600428
     GeneTests : VAV2
     CGAP : VAV2
     PMID : 7762982

< Top >


Somatic Mutaions        (help)
Lung cancer Adenocarcinoma Squamous Cell Carcinoma
Unique Mutated Samples % Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
Unique Mutated
Samples
% Mutated Total Unique
Samples
2 1.00 200 2 1.06 189 0 0.00 0
Sample datas
Sample Name Histology Subtype DNA Mutation Protein Mutation Mutation Description Zygosity Genomic Co-ordinates NCBI36 Pubmed
16814 AD c.301G>T p.D101Y Substitution - Missense Heterozygous 9:135794066-13579406618948947
16951 AD c.428G>T p.R143L Substitution - Missense Heterozygous 9:135689236-13568923618948947

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205536_at  0.60  2.49e-6  6.16e-6  -1.89  3.86e-32  6.67e-32
 HG_U133A  205537_s_at  0.29  1.50e-2  2.27e-2  0.36  5.46e-4  6.13e-4
 HG_U133_Plus2  205536_at  0.15  2.99e-1  3.86e-1  0.06  7.70e-1  8.07e-1
 HG_U133_Plus2  205537_s_at  0.72  1.64e-5  6.03e-5  0.48  1.94e-2  3.01e-2
 HG_U133_Plus2  226063_at  0.08  2.34e-1  3.15e-1  -0.20  2.74e-2  4.12e-2
 Stanford  104  1.20  4.17e-4  8.25e-3  0.31  2.97e-1  5.38e-1
 Stanford  9314  1.17  4.67e-3  3.92e-2  0.87  1.87e-2  1.06e-1
 Agilent_HS_21.6K  13675  -0.27  4.63e-3  2.55e-2  -0.25  7.46e-4  4.25e-3

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205536_at  -1.09  3.61e-2  7.07e-1  0.68  6.63e-2  1.00e+0
 HG_U133A  205537_s_at  -0.07  7.45e-1  9.74e-1  0.35  7.14e-2  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 205536_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205537_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205536_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205537_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 226063_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 104    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9314    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13675    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vav2 ovarian tumor In this study we initially examined the interaction between CD44v3 (a hyaluronan (HA) receptor) and Vav2 (a guanine nucleotide exchange factor) in human ovarian tumor cells (SK-OV-3.ipl cell line). 11606575 Human
vav2 breast cancer These data suggest that the PRL-mediated activation of Nek3 contributes differentially to Vav2 signaling pathways involving Rac1 and signal transducer and activator of transcription 5 and implicates Nek3 during PRL-mediated actions in breast cancer. 15618286 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.