IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DCT Ensembl ENSG00000080166 Chromosome 13 Start 93889844 End 93929924
Description L-dopachrome tautomerase Precursor (DCT)(DT)(EC 5.3.3.12)(L-dopachrome Delta-isomerase)(Tyrosinase-related protein 2)(TRP-2)(TRP2) [Source:UniProtKB/Swiss-Prot;Acc:P40126]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2709
     Entrez Gene : 1638
     UCSC : uc001vlv.3
     GeneCards : 2709
     RefSeq : NM_001129889
     CCDS : CCDS9470.1
     Uniprot : P40126
     Interpro : P40126
     OMIM : 191275
     GeneTests : DCT
     CGAP : DCT
     PMID : 8306979

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31464_at  0.01  9.73e-1  9.81e-1  -0.04  9.15e-1  9.43e-1
 HG_U95  31465_g_at  -0.14  1.68e-1  2.53e-1  -0.17  2.65e-1  3.65e-1
 HG_U95  41182_at  -0.20  2.30e-1  3.28e-1  -0.42  4.36e-2  8.17e-2
 HG_U133A  205337_at  -0.43  5.76e-3  9.36e-3  2.89  1.69e-49  3.82e-49
 HG_U133A  205338_s_at  -0.26  1.47e-8  4.56e-8  0.34  4.28e-2  4.56e-2
 HG_U133A  216512_s_at  0.27  5.11e-3  8.37e-3  0.75  1.85e-11  2.38e-11
 HG_U133A  216513_at  0.08  6.16e-1  6.62e-1  1.17  2.15e-12  2.80e-12
 HG_U133_Plus2  205337_at  -0.27  2.17e-1  2.96e-1  -0.19  4.27e-1  4.89e-1
 HG_U133_Plus2  205338_s_at  0.92  5.44e-6  2.18e-5  1.65  3.21e-10  1.45e-9
 HG_U133_Plus2  216512_s_at  0.26  1.15e-1  1.73e-1  0.73  9.55e-5  2.14e-4
 HG_U133_Plus2  216513_at  0.18  3.65e-1  4.55e-1  0.12  6.17e-1  6.69e-1
 Stanford  7598  -2.17  1.49e-5  9.35e-4  -2.36  2.52e-6  1.85e-4
 Stanford  11691  -1.00  2.30e-3  2.48e-2  -0.51  1.98e-1  4.22e-1
 Agilent_HS_21.6K  16598  0.07  2.62e-3  1.65e-2  0.09  4.03e-4  2.55e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205337_at  0.38  5.59e-1  9.42e-1  0.15  6.52e-1  1.00e+0
 HG_U133A  205338_s_at  0.01  9.66e-1  9.98e-1  -0.02  8.29e-1  1.00e+0
 HG_U133A  216512_s_at  -0.32  2.84e-1  8.70e-1  -0.27  1.89e-1  1.00e+0
 HG_U133A  216513_at  -0.66  1.99e-1  8.30e-1  -0.02  9.57e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31464_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 31465_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41182_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205337_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205338_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216512_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216513_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205337_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205338_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216512_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216513_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7598    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11691    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16598    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tyrp2 melanoma Treatment of human melanoma cells with the differentiation-inducing agent hexamethylene bisacetamide (HMBA) results in reciprocal changes in expression of melanocyte-specific genes tyrosinase-related proteins-1 and -2 (TYRP1 and TYRP2). 11310793 Human
tyrp2 human malignant melanoma This review will summarize our findings as well as discuss the possible mechanisms by which TYRP2 over-expression contributes to intrinsic resistance in human malignant melanoma. 11831643 Human
tyrp2 melanoma Northern and Western blot analyses revealed that the expression of TYRP2 in the virally-derived cell lines as well as in a panel of human melanoma cell lines positively correlated with their levels of resistance to CDDP. 10656687 Human
tyrp2 melanoma Overall, these results demonstrate a novel mechanism of drug resistance in human melanoma cells that is mediated by the over-expression of TYRP2. 10656687 Human
tyrp2 melanoma In summary, these findings suggest a significant role for TYRP2 in the intrinsic drug resistance phenotype of human melanoma cells and may have important implications in the development of chemosensitization strategies for the clinical management of this 10656687 Human
tyrp2 melanoma We have recently demonstrated that the constitutive expression of TYRP2 in human melanoma cells positively correlates with cis-diamminedichloroplatinum (II) (CDDP) resistance, and that the ectopic expression of TYRP2 in CDDP-sensitive cells rendered them 11095412 Human
tyrp2 melanoma Here, we demonstrate that this correlation between constitutive TYRP2 expression and CDDP resistance applies to a panel of distinct human melanoma cell lines obtained from patients with melanoma at various stages of disease progression. 11095412 Human
tyrp2 melanoma Together, these results further support the notion that TYRP2 is a novel mediator of CDDP resistance in melanoma cells and suggest that this function of TYRP2 is independent of cellular melanin content and of the other regulatory enzymes of the melanogeni 11095412 Human
dct melanoma Moreover, the levels of DCT in a variety of human melanoma cell lines correlated with their relative levels of radioresistance and the enforced expression of DCT conferred increased resistance to UV(B) treatment. 14712208 Human
dct melanoma Indeed, DCT overexpression in a melanoma cell line resulted in increased ERK activity. 14712208 Human
dct melanoma Moreover, ectopic expression of dominant-active MEK in this melanoma cell line conferred UV(B) resistance suggesting that the ERK/MAPK pathway downstream of DCT may play a critical role in radiation and drug resistance. 14712208 Human
dct melanoma To get more insight on the molecular mechanisms involved in psoralens-induced melanogenesis, we determined tyrosinase and DCT activities as well as mRNA and protein levels of tyrosinase, DCT, and TRP-1 in S91 mouse melanoma cells treated by 5-MOP. 7855073 Mouse
dct melanoma Several reports have been published about the level of activity and possible functions of dopachrome tautomerase (DCT) in mouse melanoma cells. 7858411 Human
dct melanoma We have measured the tyrosinase and DCT activities, as well as the melanin content, in mouse Cloudman melanoma cells, two lines of human melanoma, and three lines of normal human melanocytes obtained from fetal skin. 7858411 Human
dct melanoma The two lines of human melanoma cells tested had lower levels of DCT activity than Cloudman melanoma cells. 7858411 Human
dct melanoma At least in B16 mouse melanoma, DCT is present in higher catalytic amounts than tyrosinase. 8234201 Mouse
dct cancer By using recombinant adenoviruses that express TYR, tyrosinase-related protein 1 (TYRP1) or DOPAchrome tautomerase (DCT), we analyzed the biological function of these proteins with regard to melanin production and the growth of melanocytes, fibroblasts, m 15265682 Human
dct melanoma By using recombinant adenoviruses that express TYR, tyrosinase-related protein 1 (TYRP1) or DOPAchrome tautomerase (DCT), we analyzed the biological function of these proteins with regard to melanin production and the growth of melanocytes, fibroblasts, m 15265682 Human
dct melanoma However, when TYRP1 or DCT was coexpressed with TYR in melanocytes and melanoma cells, TYR-mediated cell death was clearly decreased. 15265682 Human
dct melanoma Indeed, beta-catenin is found in about 30% of human melanoma nuclei, indicating a potentially specific role for this signaling pathway in this aggressive type of cancer.beta-catenin can induce ubiquitous genes such as myc or cyclinD1, cell lineage-restric 16146765 Human
dopachrome tautomerase melanoma Effect of amphotericin B on dopachrome tautomerase activity and other melanogenic parameters in cultured B16/F10 melanoma cells. 1492075 Mouse
dopachrome tautomerase melanoma The antifungal reagent Fungizone (amphotericin B and deoxycholate) caused an activation in dopachrome tautomerase and dopa oxidase activities of B16/F10 melanoma cells at the routine concentration (2.5 micrograms/ml) used for preventing molds and yeast gr 1492075 Mouse
dopachrome tautomerase melanoma Pigment production in murine melanoma cells is regulated by tyrosinase, tyrosinase-related protein 1 (TRP1), DOPAchrome tautomerase (TRP2), and a melanogenic inhibitor. 8429235 Mouse
dopachrome tautomerase melanoma Using antibodies that recognize either tyrosinase, tyrosinase-related protein-1 (TRP1), or tyrosinase-related protein-2 (TRP2, DOPAchrome tautomerase), the quantities of those melanogenic enzymes were analyzed in five melanoma cell lines that possess vari 8429235 Human
dopachrome tautomerase melanoma Although tyrosinase has been considered for a long time the only enzyme involved in mammalian melanosynthesis, it has been shown that mouse melanoma melanosomes contain high levels of dopachrome tautomerase (DCT2), an enzyme catalyzing DC tautomerization 8234201 Mouse
dopachrome tautomerase melanoma During the first 24 hr, B16-F10 murine melanoma cells responded to conditioned media by demonstrating a considerable increase in activities of tyrosine hydroxylase, dopa oxidase, and dopachrome tautomerase, but no effect was observed on melanin content. 7905626 Mouse
dopachrome tautomerase cloudman s91 melanoma Tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2, (TRP-2, dopachrome tautomerase) were shown by immunoblotting and enzyme assays to copurify from extracts of Cloudman S91 melanoma cells. 8040609 Mouse
dopachrome tautomerase melanoma Several reports have been published about the level of activity and possible functions of dopachrome tautomerase (DCT) in mouse melanoma cells. 7858411 Human
dopachrome tautomerase melanoma Penicillin and streptomycin, the most widely used antibiotics in mammalian cell cultures, caused a moderate stimulation in dopa oxidase and tyrosine hydroxylase activities, but a slight inactivation in the dopachrome tautomerase activity of B16/F10 melano 7659681 Mouse
dopachrome tautomerase melanoma The expression of various melanogenic proteins, including tyrosinase, the tyrosinase-related proteins 1 (TRP1) and 2 (TRP2/DOPAchrome tautomerase), and the silver protein in human melanocytes was studied in six different human melanoma cell lines and comp 7659683 Human
dopachrome tautomerase melanoma Although several of the melanoma cell lines possessed significant activities of TRP2, the levels of DOPAchrome tautomerase in extracts of human cells were relatively low compared to those in murine melanocytes. 7659683 Human
dopachrome tautomerase melanoma Melatonin was found to have a small inhibitory effect on tyrosinase activity and a slight stimulatory action on dopachrome tautomerase activity in B16 mouse melanoma cells. 7556159 Mouse
dopachrome tautomerase melanomas For example, it has been shown that formation of (HO)2IndCOOH from dopachrome is catalyzed by dopachrome tautomerase, that the melanogenic protein tyrosinase-related protein (TRP)-1 can oxidize (HO)2IndCOOH to its indole quinone, that (HO)2IndCOOH-melanin 8617263 Mouse
dopachrome tautomerase melanoma We have found that a melanization inhibitory factor (MIF) extracted from the ventral skin of Rana forreri has a slight inhibitory effect on the activity levels of tyrosinase and dopachrome tautomerase in B16/F10 and Cloudman S-91 murine melanoma cell line 9125755 Mouse
dopachrome tautomerase melanoma To identify such peptides, we evaluated HLA-A*02+ melanoma patients immunized to a polyvalent vaccine containing multiple Ags, including MAGE-3, Melan-A/MART-1, gp100, tyrosinase, melanocortin receptor (MC1R), and dopachrome tautomerase (TRP-2). 9862732 Human
dopachrome tautomerase retinoblastoma Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma. 11180971 Human
dopachrome tautomerase b16 melanoma Stable transfection of B16 melanoma cells with plasmids containing the full length MSG1 or its deletion mutants, however, generated cell lines that showed an increase in levels of tyrosinase, dopachrome tautomerase and cellular melanin when compared with 11434569 Human
dopachrome tautomerase melanoma In particular, melan-A, acid phosphatase 5, dopachrome tautomerase, S100-beta and acid ceramidase were found to be among the most important genes for melanoma. 12675527 Human
dopachrome tautomerase neoplasia To confirm the involvement of Grm1 in melanocytic neoplasia, we created an additional transgenic line with Grm1 expression driven by the dopachrome tautomerase promoter. 12704387 Human
dopachrome tautomerase melanoma Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. 14712208 Human
dopachrome tautomerase cancer By using recombinant adenoviruses that express TYR, tyrosinase-related protein 1 (TYRP1) or DOPAchrome tautomerase (DCT), we analyzed the biological function of these proteins with regard to melanin production and the growth of melanocytes, fibroblasts, m 15265682 Human
dopachrome tautomerase melanoma By using recombinant adenoviruses that express TYR, tyrosinase-related protein 1 (TYRP1) or DOPAchrome tautomerase (DCT), we analyzed the biological function of these proteins with regard to melanin production and the growth of melanocytes, fibroblasts, m 15265682 Human

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