IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ABCC4 Ensembl ENSG00000125257 Chromosome 13 Start 94470084 End 94751688
Description Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4)(MRP/cMOAT-related ABC transporter)(Multi-specific organic anion transporter B)(MOAT-B) [Source:UniProtKB/Swiss-Prot;Acc:O15439]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 55
     Entrez Gene : 10257
     UCSC : uc001vmd.3
     GeneCards : 55
     RefSeq : NM_001105515
     CCDS : CCDS9474.1
     Uniprot : O15439
     Interpro : O15439
     OMIM : 605250
     GeneTests : ABCC4
     CGAP : ABCC4
     PMID : 8894702

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1931_at  -0.21  4.04e-1  5.11e-1  -0.66  4.23e-2  7.99e-2
 HG_U95  34955_at  -0.03  8.78e-1  9.14e-1  -1.07  7.59e-5  3.11e-4
 HG_U133A  203196_at  -0.25  3.38e-2  4.84e-2  1.94  1.69e-80  6.92e-80
 HG_U133_Plus2  1554918_a_at  0.43  1.51e-2  2.94e-2  0.01  9.55e-1  9.64e-1
 HG_U133_Plus2  1555039_a_at  0.54  6.12e-4  1.66e-3  0.32  3.10e-2  4.62e-2
 HG_U133_Plus2  203196_at  -0.35  1.57e-2  3.05e-2  -0.69  5.52e-6  1.47e-5
 HG_U133_Plus2  243928_s_at  -5.05  1.43e-41  3.48e-39  -5.93  5.97e-49  6.95e-46
 HG_U133_Plus2  244053_at  -0.06  7.44e-1  8.02e-1  0.01  9.46e-1  9.57e-1
 Stanford  19263  -0.14  7.40e-1  8.53e-1  -0.36  1.52e-1  3.58e-1
 Agilent_HS_21.6K  17  0.05  1.50e-1  3.09e-1  0.04  2.23e-1  3.71e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203196_at  1.00  1.43e-2  6.83e-1  -0.37  2.64e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1931_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 34955_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203196_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554918_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1555039_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203196_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243928_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 244053_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19263    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mrp4 glioblastoma Furthermore, our results that exhibit protein expression of MRP1 and MRP3 and gene expression of MRP4 and MRP5 in these 2 glioblastoma cell lines suggest new mechanisms that could lead to a MDR phenotype of tumour cells in patients with glioblastoma multi 11857404 Human
mrp4 glioblastoma multiforme Furthermore, our results that exhibit protein expression of MRP1 and MRP3 and gene expression of MRP4 and MRP5 in these 2 glioblastoma cell lines suggest new mechanisms that could lead to a MDR phenotype of tumour cells in patients with glioblastoma multi 11857404 Human
mrp4 tumour Furthermore, our results that exhibit protein expression of MRP1 and MRP3 and gene expression of MRP4 and MRP5 in these 2 glioblastoma cell lines suggest new mechanisms that could lead to a MDR phenotype of tumour cells in patients with glioblastoma multi 11857404 Human
mrp4 acute lymphoblastic leukemias MRP4 and MRP5 confer resistance to cytotoxic thiopurine nucleotides, and we demonstrate MRP4 expression varies among acute lymphoblastic leukemias, suggesting this as a factor in response to chemotherapy with these agents. 12423063 Human
mrp4 lung cancer To investigate the roles played by the multidrug resistance-associated protein (MRP1) homologues MRP3 and MRP4 in resistance to platinum drugs, we examined steady-state levels of mRNA for both MRP3 and MRP4 in normal lung and lung cancer specimens as well 11477564 Human
mrp4 lung cancer MRP3 and MRP4 gene expression levels were monitored in the PMN of 10 previously untreated lung cancer patients within 24 hr after carboplatin (CBDCA) administration. 11477564 Human
mrp4 tumor Furthermore, MRP3 expression levels in normal lung and tumor tissues from autopsy samples that had been exposed to platinum drugs while the patients were alive were significantly higher than those in unexposed tissues, but again MRP4 expression levels rem 11477564 Human
mrp4 small-cell lung cancer Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine. 12792791 Human
mrp-4 tumors As possible ATPases targeted by PBCD, all of these tumors expressed MRP-1, -4, and -7 genes, with expression of MRP-4 being greatest in each case. 10999764 Human
mrp4 small cell lung cancer (sclc) Using a collection of small cell lung cancer (SCLC) and non-SCLC patient samples and unselected cell lines established from patients at various stages of treatment, we examined the expression of MRP2, MRP3, MRP4, and MRP5, as well as MDR1 and MRP, by PCR. 10100721 Human
mrp4 acute lymphoblastic leukemia (all) In this study the expression of the MRP2, MRP3, MRP4, MRP5, and SMRP genes was measured using TaqMan real-time polymerase chain reaction (PCR) in 103 children with previously untreated acute lymphoblastic leukemia (ALL) (precursor B-cell ALL [B-ALL], n = 12816874 Human
mrp4 childhood acute myeloid leukemia Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia. 12631611 Human
mrp4 acute myeloid leukemia EXPERIMENTAL DESIGN: In this study, the expression of the MRP2, MRP3, MRP4, MRP5, and SMRP genes was measured using TaqMan real-time PCR in 53 children with de novo acute myeloid leukemia. 12631611 Human
abcc4 neuroblastoma Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. 15827327 Human
mrp-4 pleural mesotheliomas These same MRP genes, including, to a lesser extent, MRP-4, were also expressed in pleural mesotheliomas derived from patients as shown by the same methodology. 11595715 Human
mrp4 pancreatic carcinoma Here, we quantified the mRNA expression of BCRP and of all MRP family members in normal human pancreas and pancreatic carcinoma and analyzed the mRNA level of the transporters most abundantly expressed in pancreatic tissue, BCRP, MRP1, MRP3, MRP4 and MRP5 15688370 Human
mrp4 tumor The expression of BCRP, MRP1 and MRP4 mRNA did not correlate with tumor stage or grading. 15688370 Human
mrp4 neuroblastoma Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. 15827327 Human
mrp4 neuroblastoma We observed frequent MRP4 overexpression in aggressive primary neuroblastoma, a disease for which we have previously shown MRP1 to be a prognostic indicator. 15827327 Human
mrp4 solid tumors Although MRP4 is known to transport some nucleoside analogues, it has not previously been associated with resistance to drugs used to treat solid tumors. 15827327 Human
mrp4 neuroblastoma These results suggest that MRP4 will be a useful prognostic marker for neuroblastoma and that clinical trials of irinotecan as a neuroblastoma treatment should monitor MRP4 expression. 15827327 Human
mrp4 acute leukemia The aim of the present study was to analyze the association between eight ABC-transporters (BCRP, MDR1, SMRP, MRP1, MRP2, MRP3, MRP4, and MRP5) and in vitro drug resistance.Leukemic cells from 52 children with previously untreated acute leukemia (ALL: n=3 16109615 Human
mrp4 aml The aim of the present study was to analyze the association between eight ABC-transporters (BCRP, MDR1, SMRP, MRP1, MRP2, MRP3, MRP4, and MRP5) and in vitro drug resistance.Leukemic cells from 52 children with previously untreated acute leukemia (ALL: n=3 16109615 Human

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