IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CLDN10 Ensembl ENSG00000134873 Chromosome 13 Start 94883859 End 95029907
Description Claudin-10 (OSP-like protein) [Source:UniProtKB/Swiss-Prot;Acc:P78369]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2033
     Entrez Gene : 9071
     UCSC : uc001vmh.2
     GeneCards : 2033
     RefSeq : NM_001160100
     CCDS : CCDS9475.1
     Uniprot : P78369
     Interpro : P78369
     GeneTests : CLDN10
     CGAP : CLDN10
     PMID : 18025272

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39579_at  1.93  1.18e-5  6.00e-5  2.22  2.95e-5  1.33e-4
 HG_U133A  205328_at  1.07  1.55e-8  4.78e-8  0.36  7.89e-9  9.70e-9
 HG_U133_Plus2  1556687_a_at  1.28  1.44e-8  8.58e-8  1.05  2.04e-6  5.74e-6
 HG_U133_Plus2  205328_at  1.95  2.22e-12  2.19e-11  1.20  4.28e-8  1.49e-7
 Stanford  8485  0.89  9.35e-2  2.37e-1  0.09  8.09e-1  9.12e-1
 Stanford  13644  1.53  7.99e-3  5.56e-2  1.00  1.28e-2  8.21e-2
 Agilent_HS_21.6K  18635  0.19  1.26e-1  2.75e-1  0.13  3.02e-2  8.45e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205328_at  0.44  4.68e-1  9.21e-1  -0.01  9.78e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39579_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205328_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1556687_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205328_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8485    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13644    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18635    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
claudin-10 hepatocellular carcinoma Comparison of CT enhancement patterns and histologic features in hepatocellular carcinoma up to 2 cm: Assessment of malignant potential with claudin-10 immunohistochemistry. 17390062 Human
claudin-10 hcc The purpose of this study was to compare features of computed tomography (CT) and histologic features of hepatocellular carcinoma (HCC) of up to 2 cm in diameter with the immunohistochemical staining pattern of claudin-10, a recently identified prognostic 17390062 Human
claudin-10 hepatocellular carcinoma (hcc) The purpose of this study was to compare features of computed tomography (CT) and histologic features of hepatocellular carcinoma (HCC) of up to 2 cm in diameter with the immunohistochemical staining pattern of claudin-10, a recently identified prognostic 17390062 Human
claudin-10 primary hepatocellular carcinoma Claudin-10 Expression Level is Associated with Recurrence of Primary Hepatocellular Carcinoma. 15701840 Human
claudin-10 hcc CONCLUSION: Claudin-10 expression of HCC can be used as a molecular marker for disease recurrence after curative hepatectomy. 15701840 Human
claudin-10 hcc Quantitative RT-PCR was repeated on a separate HCC sample set and the association of claudin-10 expression with recurrence was again confirmed (hazard ratio, 1.2; 95% confidence interval, 1.0-1.4; P = 0.011). 15701840 Human
claudin-10 hccs To address this issue, we evaluated the cDNA microarray gene expression profiles of HCCs and identified claudin-10 expression level was associated with disease recurrence. 15701840 Human
claudin10 tumor Expression profiles of 21 claudins in 17 synovial sarcoma tumor samples, including 9 biphasic tumors, identified claudin4, claudin7, and claudin10 as biphasic tumor-related claudins, and immunohistochemical analyses demonstrated the localization of these 17060315 Human
claudin10 tumors Expression profiles of 21 claudins in 17 synovial sarcoma tumor samples, including 9 biphasic tumors, identified claudin4, claudin7, and claudin10 as biphasic tumor-related claudins, and immunohistochemical analyses demonstrated the localization of these 17060315 Human
claudin10 synovial sarcoma Expression profiles of 21 claudins in 17 synovial sarcoma tumor samples, including 9 biphasic tumors, identified claudin4, claudin7, and claudin10 as biphasic tumor-related claudins, and immunohistochemical analyses demonstrated the localization of these 17060315 Human
claudin-10 hcc The assay was repeated on a separate HCC sample set to consolidate the prognostic significance of claudin-10. 15701840 NA
cldn-10 hepatocellular carcinoma Previously, we showed that down-regulation of claudin-10 (CLDN-10) in hepatocellular carcinoma is associated with prolonged disease-free survival after curative surgery. 18025272 Human
cldn-10 hepatocellular carcinoma The biological role of CLDN-10 in hepatocellular carcinoma is unexplored. 18025272 Human
cldn-10 hepatocellular carcinoma In the current study, we investigated the CLDN-10 function in two different hepatocellular carcinoma cell lines by in vitro assays with the CLDN-10 overexpression and small interfering RNA-mediated knockdown transfectants. 18025272 Human
cldn-10 hepatocellular carcinoma We observed that overexpression of CLDN-10 conferred malignant phenotypes to hepatocellular carcinoma cells, Hep3B, which lack CLDN-10 expression, by promoting cancer cell survival, motility, and invasiveness. 18025272 Human
cldn-10 cancer We observed that overexpression of CLDN-10 conferred malignant phenotypes to hepatocellular carcinoma cells, Hep3B, which lack CLDN-10 expression, by promoting cancer cell survival, motility, and invasiveness. 18025272 Human
cldn-10 hepatocellular carcinoma Increase in mRNA transcription and protein expression of membrane type 1-MMP (MT1-MMP) was also observed in the CLDN-10 transfectants, where MT1-MMP was a protease shown to promote intrahepatic metastasis in hepatocellular carcinoma in our earlier study. 18025272 Human
cldn-10 cancer In addition, CLDN-1, CLDN-2, and CLDN-4 was up-regulated in CLDN-10 overexpression transfectants, indicating that the expression of CLDN-10 in cancer cells might affect the expression levels of its family members. 18025272 Human
cldn-10 hepatocellular carcinoma These findings showed that CLDN-10 is functionally involved in hepatocellular carcinoma invasion and is a potential target for hepatocellular carcinoma therapy. 18025272 Human
cldn10 tumor Some candidate tumor related genes, such as SMR3B, MUC7, EPHA5, SPP1 and CLDN10, were detected with over 1.5-fold amplification. 18717013 Human
claudin-10 hepatocellular carcinoma Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. 18025272 Human
claudin-10 hepatocellular carcinoma Previously, we showed that down-regulation of claudin-10 (CLDN-10) in hepatocellular carcinoma is associated with prolonged disease-free survival after curative surgery. 18025272 Human

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