IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DNAJC3 Ensembl ENSG00000102580 Chromosome 13 Start 95127394 End 95241598
Description DnaJ homolog subfamily C member 3 Precursor (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor)(Protein kinase inhibitor of 58 kDa)(Protein kinase inhibitor p58) [Source:UniProtKB/Swiss-Prot;Acc:Q13217]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9439
     Entrez Gene : 5611
     UCSC : uc001vmq.2
     GeneCards : 9439
     RefSeq : NM_006260
     CCDS : CCDS9479.1
     Uniprot : Q13217
     Interpro : Q13217
     OMIM : 601184
     GeneTests : DNAJC3
     CGAP : DNAJC3
     PMID : 7511204

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33208_at  0.64  1.72e-3  5.07e-3  0.07  8.18e-1  8.70e-1
 HG_U133A  208499_s_at  0.99  3.20e-19  2.38e-18  4.53  3.00e-104  2.29e-103
 HG_U133_Plus2  1558080_s_at  0.39  6.15e-3  1.33e-2  -0.52  1.14e-3  2.18e-3
 HG_U133_Plus2  208499_s_at  0.49  4.18e-5  1.43e-4  -0.23  1.38e-1  1.80e-1
 HG_U133_Plus2  225284_at  -0.04  6.28e-1  7.03e-1  -0.46  5.40e-9  2.10e-8
 HG_U133_Plus2  233351_at  -0.21  2.66e-1  3.50e-1  -0.37  7.77e-2  1.07e-1
 HG_U133_Plus2  235341_at  0.75  8.91e-8  4.77e-7  0.57  2.23e-7  7.11e-7
 Stanford  4008  -0.25  5.78e-1  7.41e-1  -0.39  2.55e-1  4.93e-1
 Stanford  15659  0.73  2.43e-2  1.14e-1  0.51  4.22e-2  1.51e-1
 Stanford  20862  -0.27  6.03e-1  7.59e-1  -0.42  1.75e-1  3.91e-1
 Agilent_HS_21.6K  1740  -0.07  4.34e-1  6.17e-1  -0.23  9.88e-3  3.55e-2
 Agilent_HS_21.6K  9878  -0.03  6.75e-1  8.06e-1  -0.14  3.34e-2  9.10e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208499_s_at  -0.17  6.48e-1  9.60e-1  -0.35  2.46e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33208_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208499_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558080_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208499_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225284_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 233351_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 235341_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4008    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15659    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20862    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1740    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9878    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
p58ipk tumors Northern blot analyses of 8 weeks and 1 year TFF1 null tumors confirmed that GRP78, ERp72, p58IPK, CHOP10, and Clusterin overexpression is a common and permanent feature shared by all TFF1 null antropyloric tumors. 12359958 Human
p58 lymphocytic leukemia Using [35S] methionine-labeled cell lines and immunoprecipitation, we have demonstrated the constitutive expression of p70 as well as a major component at p58 and a number at lower molecular weights in the myeloid leukemia cell lines HL60, KG1, K562 and U 3172816 Human
p58 myeloid leukemia Using [35S] methionine-labeled cell lines and immunoprecipitation, we have demonstrated the constitutive expression of p70 as well as a major component at p58 and a number at lower molecular weights in the myeloid leukemia cell lines HL60, KG1, K562 and U 3172816 Human
p58 human tumor We found that the N-myc protein from human tumor cell lines appears as four closely migrating polypeptide bands (p58 to p64) in sodium dodecyl sulfate-polyacrylamide gels. 2657399 Human
p58ipk hcc RESULTS: PKR protein levels were consistently increased in HCV-related HCC compared with NT (p=0.001); similar increases were seen in total eIF2alpha and the PKR inhibitor p58IPK in T compared with NT (p=0.022, p=0.048, respectively). 14638359 Human

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