IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RAP2A Ensembl ENSG00000125249 Chromosome 13 Start 96884475 End 96918243
Description Ras-related protein Rap-2a Precursor (RbBP-30) [Source:UniProtKB/Swiss-Prot;Acc:P10114]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 9861
     Entrez Gene : 5911
     UCSC : uc001vnd.2
     GeneCards : 9861
     RefSeq : NM_021033
     CCDS : CCDS9485.1
     Uniprot : P10114
     Interpro : P10114
     OMIM : 179540
     GeneTests : RAP2A
     CGAP : RAP2A

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1819_at  -1.02  1.36e-6  8.66e-6  -1.42  1.99e-5  9.34e-5
 HG_U95  41317_at  -0.59  9.91e-3  2.32e-2  -0.80  9.44e-3  2.20e-2
 HG_U95  41318_g_at  -0.79  2.08e-4  7.84e-4  -1.47  2.06e-5  9.67e-5
 HG_U95  41319_at  0.02  8.43e-1  8.89e-1  0.03  8.02e-1  8.58e-1
 HG_U133A  214103_s_at  0.02  8.46e-1  8.70e-1  3.48  1.09e-121  1.39e-120
 HG_U133A  214487_s_at  0.50  1.61e-7  4.50e-7  1.62  1.62e-27  2.62e-27
 HG_U133A  221830_at  -0.46  4.50e-8  1.32e-7  -2.56  6.29e-72  2.12e-71
 HG_U133_Plus2  214103_s_at  -0.07  5.43e-1  6.28e-1  0.14  3.33e-1  3.93e-1
 HG_U133_Plus2  214487_s_at  0.16  3.56e-1  4.46e-1  0.15  3.31e-1  3.92e-1
 HG_U133_Plus2  221830_at  -0.37  3.96e-5  1.36e-4  -0.68  1.23e-9  5.20e-9
 HG_U133_Plus2  225585_at  -0.46  2.62e-6  1.11e-5  -0.71  9.90e-12  5.35e-11
 Stanford  4134  -0.55  1.20e-1  2.81e-1  -0.41  1.60e-1  3.70e-1
 Stanford  20145  -0.61  4.17e-2  1.39e-1  -0.53  6.20e-2  1.98e-1
 Stanford  22690  -0.20  4.75e-1  6.62e-1  0.27  3.13e-1  5.54e-1
 Agilent_HS_21.6K  13998  0.17  7.49e-2  1.93e-1  0.24  1.14e-1  2.28e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  214103_s_at  -0.49  2.22e-2  6.83e-1  0.04  8.09e-1  1.00e+0
 HG_U133A  214487_s_at  0.86  3.58e-2  7.07e-1  -0.36  1.47e-1  1.00e+0
 HG_U133A  221830_at  -0.12  6.74e-1  9.65e-1  0.04  7.92e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1819_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41317_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41318_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 41319_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214103_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214487_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 221830_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214103_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214487_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221830_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225585_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 4134    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20145    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22690    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13998    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rap2 adenocarcinoma of the salivary gland A severe decrease in the expression of the rap1A gene was shown in the fibrosarcomas and the adenocarcinoma of the salivary gland studied, as compared to their normal counterparts, whereas no rap2 expression was found in the polyadenylated RNA of sarcoma 2514150 Human
rap2 human erythroleukemia Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. 1900292 Human
rap2 fibrosarcomas A severe decrease in the expression of the rap1A gene was shown in the fibrosarcomas and the adenocarcinoma of the salivary gland studied, as compared to their normal counterparts, whereas no rap2 expression was found in the polyadenylated RNA of sarcoma 2514150 Human
rap2 sarcoma A severe decrease in the expression of the rap1A gene was shown in the fibrosarcomas and the adenocarcinoma of the salivary gland studied, as compared to their normal counterparts, whereas no rap2 expression was found in the polyadenylated RNA of sarcoma 2514150 Human
rap2 breast cancer Rap2 belongs to the Ras superfamily of GTPases, whose role in breast cancer remains unknown. 15986426 Human
rap2 neoplastic growth Elevation of the intracellular cAMP concentration ([cAMP]i) regulates metabolism, cell proliferation, and differentiation and plays roles in memory formation and neoplastic growth. cAMP mediates its effects mainly through activation of protein kinase A (P 16207818 Human
rap2 oncogenes [Are rap genes anti-oncogenes?] The products of the ras-related rap genes (rap1 and rap2) are small G-proteins that share a high degree of structural (around 50% of identical amino acids) and functional homology with the products of ras oncogenes. 8204955 Human
rap2 oncogenes Similarly, whereas overexpression of the rap1 protein is able to antagonize the transforming potential of oncogenic ras proteins, a considerable overexpression of normal or mutated rap2 proteins has no effect on cellular proliferation or transformation in 8204955 Human
rap2 oncogenic Similarly, whereas overexpression of the rap1 protein is able to antagonize the transforming potential of oncogenic ras proteins, a considerable overexpression of normal or mutated rap2 proteins has no effect on cellular proliferation or transformation in 8204955 Human
rap-2 oncogenic In contrast, rap-2 was found to cause significant oncogenic effects in OVCA cells, while SKIIP promotes only anchorage-independent growth. 16116479 Human

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