IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC15A1 Ensembl ENSG00000088386 Chromosome 13 Start 98134057 End 98202909
Description Solute carrier family 15 member 1 (Peptide transporter 1)(Oligopeptide transporter, small intestine isoform)(Intestinal H(+)/peptide cotransporter) [Source:UniProtKB/Swiss-Prot;Acc:P46059]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10920
     Entrez Gene : 6564
     UCSC : uc001vno.2
     GeneCards : 10920
     RefSeq : NM_005073
     CCDS : CCDS9489.1
     Uniprot : P46059
     Interpro : P46059
     OMIM : 600544
     GeneTests : SLC15A1
     CGAP : SLC15A1
     PMID : 7896779

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  31628_at  0.23  3.62e-1  4.69e-1  0.18  6.26e-1  7.15e-1
 HG_U95  32906_at  -0.05  8.41e-1  8.88e-1  -0.41  2.73e-1  3.74e-1
 HG_U133A  207254_at  0.10  5.75e-1  6.24e-1  3.58  2.09e-74  7.43e-74
 HG_U133A  211349_at  -0.27  7.34e-4  1.36e-3  3.77  4.18e-90  2.18e-89
 HG_U133_Plus2  207254_at  1.30  3.86e-8  2.17e-7  1.37  3.72e-8  1.31e-7
 HG_U133_Plus2  211349_at  0.37  2.53e-2  4.64e-2  1.11  3.47e-11  1.76e-10
 Agilent_HS_21.6K  7032  0.09  3.44e-2  1.12e-1  0.12  1.63e-2  5.26e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207254_at  0.30  6.08e-1  9.53e-1  0.14  7.31e-1  1.00e+0
 HG_U133A  211349_at  -0.39  1.09e-1  7.80e-1  0.34  1.93e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 31628_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 32906_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207254_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211349_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207254_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211349_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7032    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hpept1 hepatoma To explore the feasibility of drug delivery to the liver by the use of adenovirus-mediated human oligopeptide transporter (hPEPT1) gene transfer, we examined the accumulation of L-[(3)H]carnosine in the hepatoma cell line (HepG2 and WIFB9) and mouse liver 12023508 Human
hpept1 inflammatory bowel disease Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules. 11375948 Human
pept1 tumor To study the drug delivery to tumor by utilization of an oligopeptide transport activity, we examined the accumulation of dipeptides and the peptide-mimetic anti-cancer drug, bestatin, a substrate of oligopeptide transporter PepT1. 11004680 Human
pept 1 human colon carcinoma In the first approach, the human colon carcinoma cell line Caco-2 which expresses PEPT 1 and the SHR rat kidney cell line SKPT which expresses PEPT 2 were used. 9092716 Human
hpept1 crohn's disease RESULTS: hPepT1 expression occurs aberrantly in the colon with chronic ulcerative colitis (6 patients) and Crohn's disease (4 patients), but not in normal colon (4 patients) or colon with microscopic colitis (4 patients). 11375948 Human
pept-1 crohn's disease Patients with intestinal diseases, such as ulcerative colitis, Crohn's disease, and short-bowel syndrome, may have induction of the Pept-1 expression in their colon. 14561585 Human
pept1 solid tumors The tissue distribution of bestatin was significantly increased in solid tumors that overexpress PEPT1 in nude mice. 12822485 Mouse
pept1 pancreatic adenocarcinoma Previous studies with amino acid ester prodrugs of nucleoside drugs targeted to the PEPT1 transporter coupled with recent findings of the functional expression of the PEPT1 oligopeptide transporter in pancreatic adenocarcinoma cell lines suggest the poten 15827340 Human
pept1 cancer Previous studies with amino acid ester prodrugs of nucleoside drugs targeted to the PEPT1 transporter coupled with recent findings of the functional expression of the PEPT1 oligopeptide transporter in pancreatic adenocarcinoma cell lines suggest the poten 15827340 Human

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