IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PCCA Ensembl ENSG00000175198 Chromosome 13 Start 99539338 End 99980687
Description Propionyl-CoA carboxylase alpha chain, mitochondrial Precursor (PCCase subunit alpha)(EC 6.4.1.3)(Propanoyl-CoA:carbon dioxide ligase subunit alpha) [Source:UniProtKB/Swiss-Prot;Acc:P05165]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 8653
     Entrez Gene : 5095
     UCSC : uc001voo.2
     GeneCards : 8653
     RefSeq : NM_000282
     CCDS : CCDS9496.2
     Uniprot : P05165
     Interpro : P05165
     OMIM : 232000
     GeneTests : PCCA
     CGAP : PCCA
     PMID : 1427880

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1348_s_at  -0.28  2.04e-1  2.97e-1  -0.58  1.10e-2  2.50e-2
 HG_U95  37593_at  -0.34  6.33e-2  1.12e-1  -1.11  1.78e-4  6.71e-4
 HG_U133A  203860_at  0.34  4.52e-3  7.47e-3  1.70  1.53e-55  3.83e-55
 HG_U133A  216533_at  0.43  1.04e-2  1.62e-2  2.88  7.58e-41  1.49e-40
 HG_U133_Plus2  203860_at  -0.21  1.27e-1  1.88e-1  -0.44  2.08e-4  4.43e-4
 HG_U133_Plus2  216533_at  -0.12  5.74e-1  6.56e-1  -0.90  1.14e-3  2.17e-3
 HG_U133_Plus2  232376_at  -0.34  1.77e-3  4.35e-3  -0.54  1.23e-4  2.72e-4
 Stanford  6881  0.53  1.32e-1  2.98e-1  0.41  3.92e-1  6.28e-1
 Agilent_HS_21.6K  4132  0.06  6.04e-1  7.56e-1  -0.10  9.79e-2  2.05e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203860_at  0.93  2.27e-2  6.83e-1  -0.17  4.58e-1  1.00e+0
 HG_U133A  216533_at  -0.59  2.05e-1  8.32e-1  -0.21  5.53e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1348_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 37593_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203860_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216533_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203860_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216533_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 232376_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 6881    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4132    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pcca colorectal cancers Having observed a high biotin content in colon mucosae and a low content in colorectal-cancer cells, we then studied the transcription levels of PCCA and PCCB genes in 9 colorectal cancers and the corresponding mucosae. 9311592 Human
pcca colorectal cancers In all cases, the levels of mRNA were lower in colorectal cancers than in normal mucosae, the decrease being always more marked for PCCB than for PCCA. 9311592 Human
pcca cancer In normal mucosae and in adenocarcinoma cancer cells, PCCA and PCCB transcription levels were strongly related to the amount of biotin detected, but not to the number of chromosomes 13 (which carries PCCA) or 3 (which carries PCCB). 9311592 Human
pcca adenocarcinoma In normal mucosae and in adenocarcinoma cancer cells, PCCA and PCCB transcription levels were strongly related to the amount of biotin detected, but not to the number of chromosomes 13 (which carries PCCA) or 3 (which carries PCCB). 9311592 Human

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