IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC6A4 Ensembl ENSG00000108576 Chromosome 17 Start 25545463 End 25586841
Description Sodium-dependent serotonin transporter (5HT transporter)(5HTT)(Solute carrier family 6 member 4) [Source:UniProtKB/Swiss-Prot;Acc:P31645]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11050
     Entrez Gene : 6532
     UCSC : uc002hey.3
     GeneCards : 11050
     RefSeq : NM_001045
     CCDS : CCDS11256.1
     Uniprot : P31645
     Interpro : P31645
     OMIM : 182138
     GeneTests : SLC6A4
     CGAP : SLC6A4
     PMID : 7681602

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34604_at  -2.84  2.28e-36  1.60e-33  -3.00  3.06e-14  8.32e-13
 HG_U133A  207519_at  -3.00  2.90e-122  6.46e-119  -2.45  6.75e-47  1.46e-46
 HG_U133_Plus2  207519_at  -4.03  2.50e-55  4.02e-52  -3.79  7.32e-32  4.20e-30
 HG_U133_Plus2  241811_x_at  -4.77  2.26e-53  2.69e-50  -4.67  4.75e-34  3.59e-32
 HG_U133_Plus2  242009_at  -6.10  7.65e-65  2.09e-60  -5.97  1.79e-40  3.73e-38
 Agilent_HS_21.6K  11977  -0.51  1.14e-19  5.89e-17  -0.51  2.17e-13  3.04e-11

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207519_at  0.13  6.88e-1  9.67e-1  -0.55  2.04e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34604_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207519_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207519_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241811_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 242009_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11977    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
5-htt hyperplasia Among these, the finding of an association between PPH and the L-allelic variant of the serotonin transporter (5-HTT) gene indicates that 5-HTT, which controls smooth muscle hyperplasia, probably contributes to susceptibility to PPH or is an important mod 12503718 Human
5-htt choriocarcinoma As model system we used a cell line which constitutively expresses the 5-HTT, namely the choriocarcinoma cell line JAR. 9759920 Human
5-htt placental choriocarcinoma In the present study, d-fenfluramine was found to be cytotoxic to the serotonin (5-HT) transporter (5-HTT) expressing human placental choriocarcinoma cells. d-Fenfluramine caused DNA fragmentation and apoptosis. 9804303 Human
sert placental choriocarcinoma Furthermore, in heterologous (CHO and Lec4 cells) and endogenous (placental choriocarcinoma JAR cells) expression systems, we tested whether glycosyl modification also manipulates the hetero-oligomeric interactions of SERT, specifically with myosin IIA. 12944413 Human
5-htt hyperplasia BACKGROUND: The serotonin transporter (5-HTT) is involved in the pulmonary artery smooth muscle hyperplasia that leads to pulmonary hypertension (PH). 14530202 Human
5ht transporter rat basophilic leukemia We have examined the effect of receptor-activated second messengers on the 5HT transporter in rat basophilic leukemia cells (RBL 2H3). 7525554 NA
5-htt pd Density of dopamine transporter (DAT) and serotonin transporter (5-HTT) membrane proteins in the caudate-putamen (CPu) and nucleus accumbens (NAc) of rat brain was assessed at seven ages at postnatal days (PD) 7-60, by in vitro quantitative autoradiograph 9780082 Human
5-htt hyperplasia Considerable progress has been achieved over the last few years in our understanding of this disease, both through genetic studies that have identified mutations in the gene for BMP-RII (bone morphogenetic protein receptor II) in patients with familial pr 15146583 Human
5-htt hyperplasia The association between PPH and the L allelic variant of the serotonin transporter (5-HTT) gene indicates that 5-HTT, which controls smooth muscle hyperplasia, probably contributes to susceptibility to PPH or is an important modifier of the PPH phenotype. 15146583 Human
5-htt pd The current study aimed to investigate the binding of 5-HTT in the brain of patients with PD. 15598551 Human
5-htt pd The patients with current PD showed a significant decrease in 5-HTT binding in the midbrain, in the temporal lobes and in the thalamus in comparison to the controls. 15598551 Human
5-htt pd The binding of 5-HTT in patients with PD in remission was similar to findings in the control group in the midbrain and in the temporal lobes, but lower in the thalamus. 15598551 Human
5-htt oral squamous-cell carcinoma This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. 15761254 NA
5-htt oral squamous-cell carcinoma KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expression level of 5-HTT in the dorsal raphe nucleus (DRN) was examined by in situ hybridization when the tumor mass reached to -10% of total body weig 15761254 Human
5-htt tumor Plasma leptin levels were determined by radioimmunoassay method using a commercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor control. 15761254 Mouse
5-htt oral carcinoma These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level. 15761254 Mouse
5-htt hyperplasia BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs). 15927991 Human
5htt pd Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which 11326308 Human
hsert placental choriocarcinoma Similar results were obtained using human placental choriocarcinoma (JAR) cells that constitutively express the hSERT at a low level. 10869387 Human
sert pd The striatal DAT specific to non-displaceable uptake ratios of 29, and the SERT uptake measurements of 27, PD patients were compared with those of 21 and 16 controls, respectively. 11215571 Human
sert pd Additionally, this technique allows the simultaneous measurement of SERT uptake and shows that PD patients, interestingly, seem to have decreased SERT availability in the thalamic and frontal areas. 11215571 Human
sert pd AIMS: Definition of the regional pattern of dopamine transporter (DAT) dysfunction in advanced Parkinson's disease (PD) and evaluation of a potential correlation between DAT binding and symptoms; elucidation of the role of DAT imaging in the differen 12601452 Human
sert pd Significantly lower SERT binding was observed in PD midbrain and MSA hypothalamus compared to controls -- and in MSA relative to PD mesial frontal cortex. 12601452 Human
sert pd The reduction of SERT in the midbrain area of PD patients suggests additional tegmental degeneration while in MSA the serotonergic system seems to be more generally affected. 12601452 Human
sert pd Brain tissues were collected at PD 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (SERT) in the neocortex and hippocampus. 15582680 Human
sert burkitt's lymphoma Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, 15870169 Human
sert malignancy Following our previous description of the serotonin transporter (SERT) acting as a conduit to 5-hydroxytryptamine (5-HT)-mediated apoptosis, specifically in Burkitt's lymphoma, we now detail its expression among a broad spectrum of B cell malignancy, 15870169 Human
sert diffuse large b-cell lymphoma SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. 15870169 Human
sert acute lymphoblastic leukemia SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. 15870169 Human
sert multiple myeloma SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. 15870169 Human
sert mantle-cell lymphoma SERT was readily detected in derived B cell lines with origins as diverse as B cell precursor acute lymphoblastic leukemia, mantle cell lymphoma, diffuse large B cell lymphoma, and multiple myeloma. 15870169 Human
5ht transporter pd Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT) in PD, we assessed whether a functional polymorphism in the promoter of the 5HTT gene (5HTT gene-linked polymorphic region, 5HTTLPR), which 11326308 Human

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